Who had a pre-excitation syndrome of the heart named after him and introduced a new use for the drug lidocaine?
Bernard Lown Bernard Lown (born June 7, 1921) is the original developer of the DC defibrillator and the cardioverter, as well as a recipient of the Nobel Peace Prize. Lown developed the direct current defibrillator for cardiac resuscitation and the cardioverter for correcting rapid disordered heart rhythms, and introduced a new use for the drug lidocaine to control heartbeat disturbances.
Adrenergic storm An adrenergic storm is a sudden and dramatic increase in serum levels of the catecholamines adrenalin and noradrenalin (also known as epinephrine and norepinephrine respectively), with a less significant increase in dopamine transmission. It is a life-threatening condition because of extreme tachycardia and hypertension, and is especially dire for those with prior heart problems. If treatment is prompt, prognosis is good; typically large amounts of diazepam or other benzodiazepines are administered alongside beta blockers. Beta blockers are contraindicated in some patients, so other anti-hypertensive medication such as clonidine may be used. It is usually caused by overdose of stimulants, especially cocaine or methamphetamine, or eating foods high in tyramine while taking monoamine oxidase inhibitors. A subarachnoid hemorrhage can also cause an adrenergic storm. A catecholamine storm is part of the normal course of Rabies infection, and is responsible for the severe feelings of agitation, terror, and dysautonomia present in the pre-coma stage of the disease.