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1: How does ecstasy work: serotonin pathways in the brain. The nerve pathway that is predominantly affected by ecstasy is called the serotonin pathway. Serotonin is a neurotransmitter that is synthesized, stored, and released by specific neurons in this pathway.It is involved in the regulation of several processes within the brain, including mood, emotions, aggression, sleep, appetite, anxiety, memory, and perceptions.irst, describe how serotonin pathways innervate (connect to) different brain regions. Point to the cell bodies of the serotonin pathway that are located in the brainstem area the Raphe nucleus in pink).
The National Institute on Drug Abuse says this is accomplished when MDMA binds to serotonin transporters, which alters the brain's neurochemistry. From a psychological standpoint, this can result in (temporary) heightened perceptions, elevated mood, reduced appetite, and a prolonged burst of energy.