However, some people who have early-onset Alzheimer's don't have mutations in these three genes. That suggests that this early-onset form of Alzheimer's disease is linked to other genetic mutations that haven't been identified yet.
Early history Cigars, cigarettes Cancer by the carton Legal history Surgeon General's warning. (CNN) -- Tobacco was first used by the peoples of the pre-Columbian Americas. Native Americans apparently cultivated the plant and smoked it in pipes for medicinal and ceremonial purposes.
John Rolfe (1585â1622) was one of the early English settlers of North America. He is credited with the first successful cultivation of tobacco as an export crop in the Colony of Virginia and is known as the husband of Pocahontas, daughter of the chief of the Powhatan.