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exotoxin exÂ·oÂ·toxÂ·in (Äk'sÅ-tÅk'sÄ­n) n. A toxin secreted by a microorganism and released into the environment in which it grows. Also called extracellular toxin.
Exotoxins are protein toxins secreted by (+ or -) bacteria into the environment. Endotoxin is usually LPS (lipopolysaccharide), or another component of the cell membrane of Gram-negative bacteria. LPS creates a toxic immune response when released (by cell lysis) into an animal's body.n endotoxin is part of the outer portion of the cell wall of gram-negative bacteria. They are released when the bacteria die and the cell wall breaks apart. They differ from exotoxins in that they are lipopolysaccharides not proteins.