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Short-acting insulin covers your insulin needs during meals. It is taken about 30 minutes to an hour before a meal to help control blood sugar levels. This type of insulin takes effect in about 30 minutes to one hour, and peaks after two to four hours. Its effects tend to last about five to eight hours.
You typically take insulin glulisine within 15 minutes before a meal or within 20 minutes after you begin eating. With insulin lispro, you administer your injection within 15 minutes before a meal or immediately afterward.