However, some people who have early-onset Alzheimer's don't have mutations in these three genes. That suggests that this early-onset form of Alzheimer's disease is linked to other genetic mutations that haven't been identified yet.
Early history Cigars, cigarettes Cancer by the carton Legal history Surgeon General's warning. (CNN) -- Tobacco was first used by the peoples of the pre-Columbian Americas. Native Americans apparently cultivated the plant and smoked it in pipes for medicinal and ceremonial purposes.
In 1573 Drake returned from the Americas with what is thought to have been the first consignment of tobacco to enter the British Isles from English discoverers. Twelve years later, in 1585, it is rumoured that Drake introduced Raleigh to tobacco. A year later, in 1586, Raleigh sailed for the Americas and met Ralph Lane, the first Governor of Virginia, who is believed to have taught Raleigh to smoke a clay pipe.