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There are more than 400 types of anemia. These types of anemia are divided into three main groups, according to their cause. There is anemia caused by blood loss, by decreased or faulty red blood cell production, and by destruction of red blood cells.
The most common types of macrocytic anemias include vitamin B12 deficiency (including pernicious anemia), folic acid deficiency (include folate interference from oral contraceptives and other drugs), hypothyroidism, chronic liver diseases, and severe hemolytic anemias.