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Some common side effects of Depo Provera (medroxyprogesterone) are changes in menstrual periods, weight gain, weakness, tiredness, nervousness, irritability, depression, difficulty falling asleep or staying asleep, hot flashes, breast pain, swelling, or tenderness, leg cramps and back or joint pain.
Depo bleeding side effects can occur as your body is adjusting to Depo Provera. Many women report experiencing irregular bleeding (spotting) and/or prolonged bleeding (like a continuous period) during this time. Unfortunately, there is no way to know ahead of time if you might experience this Depo Provera side effect.