The acute form of hepatitis, generally caused by viral infection, is characterized by constitutional symptoms that are typically self-limiting. Chronic hepatitis presents similarly, but can manifest signs and symptoms specific to liver dysfunction with long-standing inflammation and damage to the organ.
1 Hydromorphone is a minor metabolite of morphine and may be excreted in urine at concentrations up to 2.5% of the morphine concentration. 2  Consequently, the detection of minor amounts of hydromorphone in urine containing high concentrations of codeine should not be interpreted as evidence of hydromorphone use.
Hydromorphone/ Hydrocodone Use cautiously and monitor patient carefully for symp-toms of opioid overdose. In severe hepatic impairment, the par-ent drug may not be readily converted to inactive metabolites. Decrease initial dose by 50% of the usual amount. Oxycodone Use cautiously and monitor patient carefully for symp-toms of opioid overdose. In severe hepatic impairment, the par-ent drug may not be readily converted to inactive metabolites. Decrease initial dose by 1/2 to 1/3 of the usual amount.