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exotoxin exÂ·oÂ·toxÂ·in (Äk'sÅ-tÅk'sÄ­n) n. A toxin secreted by a microorganism and released into the environment in which it grows. Also called extracellular toxin.
Exotoxins are produced by a variety of bacteria including gram-positive and gram-negative bacteria. In some species, most strains produce the same exotoxin while in others only a subset of strains produces a particular exotoxin. They are antigenic and can be toxoided. Their activity can be neutralized by antitoxins.