However, some people who have early-onset Alzheimer's don't have mutations in these three genes. That suggests that this early-onset form of Alzheimer's disease is linked to other genetic mutations that haven't been identified yet.
Early history Cigars, cigarettes Cancer by the carton Legal history Surgeon General's warning. (CNN) -- Tobacco was first used by the peoples of the pre-Columbian Americas. Native Americans apparently cultivated the plant and smoked it in pipes for medicinal and ceremonial purposes.
For in 1614, in what has been called by at least one historian the most momentous event of the 17th century, the first shipment of Virginia tobacco was sold in London. Two years later, in June, 1616, Rolfe and other leaders of the colony arrived in London to discuss the newly successful crop.