If not corrected, blood flow in the penis becomes impeded by the increasingly constricting band of foreskin, which causes further swelling of the glans. Because lack of oxygen from the reduced blood flow can cause tissue death (necrosis), paraphimosis is considered a medical emergency and requires immediate treatment.
Allantoin is a major metabolic intermediate in many other organisms including plants and bacteria.llantoin is a major metabolic intermediate in many other organisms including plants and bacteria.
In humans and higher apes, the metabolic pathway for conversion of uric acid to allantoin is not present, so the former is excreted. Recombinant rasburicase is sometimes used as a drug to catalyze this metabolic conversion in patients. In fish, allantoin is broken down further (into ammonia) before excretion.llantoin is a major metabolic intermediate in many other organisms including plants and bacteria.