The acute form of hepatitis, generally caused by viral infection, is characterized by constitutional symptoms that are typically self-limiting. Chronic hepatitis presents similarly, but can manifest signs and symptoms specific to liver dysfunction with long-standing inflammation and damage to the organ.
1 Hydromorphone is a minor metabolite of morphine and may be excreted in urine at concentrations up to 2.5% of the morphine concentration. 2  Consequently, the detection of minor amounts of hydromorphone in urine containing high concentrations of codeine should not be interpreted as evidence of hydromorphone use.
Most of morphine and hydrocodone's effects are due to their direct effects on the CNS, not so much the effects of their metabolites (although a bit of hydrocodone will metabolize into hydromorphone). So these opiates aren't a bigger no-no than other opiate combinations per say.