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exotoxin exÂ·oÂ·toxÂ·in (Äk'sÅ-tÅk'sÄ­n) n. A toxin secreted by a microorganism and released into the environment in which it grows. Also called extracellular toxin.
Exotoxins are a group of soluble proteins that are secreted by the bacterium, enter host cells, and catalyze the covalent modification of a host cell component(s) to alter the host cell physiology. Both Gram-negative and Gram-positive bacteria produce exotoxins.