However, some people who have early-onset Alzheimer's don't have mutations in these three genes. That suggests that this early-onset form of Alzheimer's disease is linked to other genetic mutations that haven't been identified yet.
Early history Cigars, cigarettes Cancer by the carton Legal history Surgeon General's warning. (CNN) -- Tobacco was first used by the peoples of the pre-Columbian Americas. Native Americans apparently cultivated the plant and smoked it in pipes for medicinal and ceremonial purposes.
In 1611 Rolfe, known as an ardent smoker, decided to experiment with cultivating tobacco in Jamestown. The plant had first been brought to England in 1565, perhaps from Florida by Sir John Hawkins, and by the 1610s there was a ready market in Britain for tobaccoâespecially Spanish tobacco from the West Indies.