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Short-acting insulin covers your insulin needs during meals. It is taken about 30 minutes to an hour before a meal to help control blood sugar levels. This type of insulin takes effect in about 30 minutes to one hour, and peaks after two to four hours. Its effects tend to last about five to eight hours.
1 Regular, also known as short-acting insulin, takes about 30 minutes to reach the bloodstream. 2  Its peak effect is in about two to three hours, and its effect lingers for three to six hours. 3  Intermediate-acting insulin reaches the bloodstream in two to four hours, peaks in four to 12 hours, and works for up to 18 hours.