The acute form of hepatitis, generally caused by viral infection, is characterized by constitutional symptoms that are typically self-limiting. Chronic hepatitis presents similarly, but can manifest signs and symptoms specific to liver dysfunction with long-standing inflammation and damage to the organ.
1 Hydromorphone is a minor metabolite of morphine and may be excreted in urine at concentrations up to 2.5% of the morphine concentration. 2  Consequently, the detection of minor amounts of hydromorphone in urine containing high concentrations of codeine should not be interpreted as evidence of hydromorphone use.
This makes it 5â10 times more potent than morphine and enhances its distribution into the brain making titration of the effects easier. In addition, due to the keto-group in position 6, hydromorphone is only glucuronidated at position 3, and does not form an active 6-glucuronide metabolite like morphine.