Acute interstitial nephritis is an important cause of acute renal failure resulting from immune-mediated tubulointerstitial injury, initiated by medications, infection, and other causes. Acute interstitial nephritis may be implicated in up to 15 percent of patients hospitalized for acute renal failure.
The first player places one of their dominoes (right-side up) on the table. The second player tries to put a domino on the table that matches one side of what's already there. If a player cannot go, the player picks a domino from the pile and skips that turn. The chain of the played dominoes develops randomly, and can look a lot like a snake.
At each subsequent turn, a player can put down only one domino on any of the trains that are available to that player. 1  The turn proceeds as follows: 2  If possible, the player plays a domino to one of the available trains (see below) and that is the end of the turn. 3  Otherwise, the player takes a domino from the boneyard.