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exotoxin exÂ·oÂ·toxÂ·in (Äk'sÅ-tÅk'sÄ­n) n. A toxin secreted by a microorganism and released into the environment in which it grows. Also called extracellular toxin.
Exotoxins can stimulate the immune system. By stimulating the immune system, they produce antitoxins to neutralize the toxin. Endotoxin vs Exotoxin. 1  Endotoxins are lipopolysaccharides, while exotoxins are soluble proteins produced by pathogenic bacteria. 2  Both gram negative and gram positive bacteria produce exotoxins while endotoxins are produced by gram negative bacteria.