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From Wikipedia, the free encyclopedia. The urea cycle (also known as the ornithine cycle) is a cycle of biochemical reactions occurring in many animals that produces urea ((NH2)2CO) from ammonia (NH3). This cycle was the first metabolic cycle discovered (Hans Krebs and Kurt Henseleit, 1932), five years before the discovery of the TCA cycle. In mammals, the urea cycle takes place primarily in the liver, and to a lesser extent in the kidney.
Medical Definition of Urea cycle disorder Urea cycle disorder: one of a number of inherited medical conditions that arise due to a deficiency in one of six enzymes involved in the urea cycle. The urea cycle is a series of biochemical reactions that convert nitrogen, a waste product of protein metabolism, to a compound called urea.