What is it: A Process Control Plan (PCP) is a summary of defect prevention and reactive detection techniques. The overall intent of the PCP is to control the product characteristics and the associated process variables to ensure capability (around the identified target or nominal) and stability of the product over time.
Various compounds can reduce the activity of enzymes. They may act in a variety of different ways, and indeed may be reversible or irreversible inhibitors of the enzyme. An irreversible inhibitor causes covalent modification of the enzyme, so that its activity is permanently reduced.
Many drugs are competitive inhibitors of specific enzymes. A classic example of competitive inhibition is the effect of malonate on the enzyme activity of succinate dehydrogenase (Figure 16.8.1). Malonate and succinate are the anions of dicarboxylic acids and contain three and four carbon atoms, respectively.