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exotoxin exÂ·oÂ·toxÂ·in (Äk'sÅ-tÅk'sÄ­n) n. A toxin secreted by a microorganism and released into the environment in which it grows. Also called extracellular toxin.
a potent toxin formed and secreted by the bacterial cell, and found free in the surrounding medium. Exotoxins are generally heat labile, and are protein in nature. Many can be detoxified with retention of antigenicity by treatment with formaldehyde (toxoid). Many are important virulence factors in pathogenic bacteria.