Leg pain is also frequently a sign of injury, such as the following: Muscle strain is a common injury that happens when the muscle fibers tear as a result of overstretching. It often occurs in the larger muscles, such as the hamstrings, calves, or quadriceps.
medical Definition of superinfection : a second infection superimposed on an earlier one especially by a different microbial agent of exogenous or endogenous origin that is resistant to the treatment used against the first infection
DNA supercoiling refers to the over-or under-winding of a DNA strand, and is an expression of the strain on that strand. Supercoiling is important in a number of biological processes, such as compacting DNA. Additionally, certain enzymes such as topoisomerases are able to change DNA topology to facilitate functions such as DNA replication or transcription.