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A look at the numbers for coronary artery disease is enough to give anyone chest pain 1  : More than 15,800,000 Americans have known coronary artery disease. 2  About 8 million of them have had heart attacks. 3  Around 500,000 people will die of coronary artery disease this year.4  More than a million will have a heart attack.n this article. Atherosclerosis -- sometimes called hardening of the arteries -- can slowly narrow and harden the arteries throughout the body. When atherosclerosis affects the arteries of the heart, itâs called coronary artery disease. Coronary artery disease is the No. 1 killer of Americans.
Coronary artery disease (CAD) is the most common type of heart disease. It is the leading cause of death in the United States in both men and women. CAD happens when the arteries that supply blood to heart muscle become hardened and narrowed. This is due to the buildup of cholesterol and other material, called plaque, on their inner walls. This buildup is called atherosclerosis. As it grows, less blood can flow through the arteries. As a result, the heart muscle can't get the blood or oxygen it needs. This can lead to chest pain (angina) or a heart attack. Most heart attacks happen when a blood clot suddenly cuts off the hearts' blood supply, causing permanent heart damage.