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exotoxin exÂ·oÂ·toxÂ·in (Äk'sÅ-tÅk'sÄ­n) n. A toxin secreted by a microorganism and released into the environment in which it grows. Also called extracellular toxin.
a potent toxin formed and excreted by the bacterial cell and found free in the surrounding medium; exotoxins are the most poisonous substances known. They are protein in nature and heat labile, and are detoxified with retention of antigenicity by treatment with formaldehyde.