Acetylcholine is released from a presynaptic neuron into the synaptic cleft. Once in the synaptic gap, acetylcholine can: - Bind to presynaptic receptors: presynaptic activation or inhibition leads to automodulation of the presynaptic cholinergic neuron.
When welts are a sign of a medical problem, they are usually accompanied by other symptoms which provide clues to the problem. Physical trauma such as a blow can cause a welt, and welts can also be caused by allergic reactions, infections, injections, insect bites, and skin reactions, in very sensitive people. For example, in people with dermographism, even a gentle touch to the skin can cause a welt to emerge.
Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the CFTR gene, and some forms are known to cause pancreatitis. Symptoms of hereditary pancreatitis may begin as early as childhood and may present as an isolated symptom or as part of a rare genetic syndrome. Hereditary pancreatitis can be inherited in a number of ways, depending on the gene(s) involved. One common cause of hereditary pancreatitis involves mutations in the PRSS1 gene.1,3 PRSS1 codes for an enzyme called cationic trypsinogen, which aids in digestion.