SKK. Either microwave or bake. Depending on the size of the potato: In microwave prick with fork to allow steam to escape and microwave for 10 - 15 minutes or until the potato feels soft enought to eat. In oven, also prick with fork and back at 350 for 30 40 minutes.1 Person agrees.epending on the size of the potato: In microwave prick with fork to allow steam to escape and microwave for 10 - 15 minutes or until the potato feels soft enought to eat. In oven, also prick with fork and back at 350 for 30 40 minutes. 1 Person agrees.
To the Editor: Somatic mutations in the gene encoding calreticulin (CALR) were recently described in the majority of patients with myeloproliferative neoplasms without mutations in the Janus kinase 2 gene (JAK2).n this patient, the CALR mutation was a deletion (p.L367fs*46), which was detected in two samples obtained before interferon alfa therapy and was reduced in two subsequent samples (Figure 1). Both patients reported moderate fatigue and mood changes, which resolved after discontinuation of interferon alfa.
Calreticulin (CALR) is a multifunctional Ca-binding protein located in the endoplasmic reticulum. CALR mutations are recurrent in JAK2 / MPL-unmutated essential thrombocythemia (ET) and primary myelofibrosis (PMF), with reported mutational frequencies of 49 and 74 % , respectively.able 1 - Clinical and laboratory features of 282 patients with primary myelofibrosis and type 1 (p.L367fs*46) or type 2 (K385fs*47) CALR or JAK2 mutations.