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An E-box (enhancer box) is a DNA response element found in some eukaryotes that acts as a protein-binding site and has been found to regulate gene expression in neurons, muscles, and other tissues.
E, in capitalized form, and e in lower-case, is the fifth letter of the Latin-based alphabet systems, including English. It has several meanings in mathematics. In pure mathematics 1  : Euler's number (e) - a constant that is highly important in higher level mathematics.