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Island of the Blue Dolphinsis based upon a real story in which the Lost Woman of San Nicolas lived alone on an island from 1835 to 1853. Karana is a twelve year-old girl living on the Island of Blue Dolphins, located about 75 miles southwest of present day Los Angeles.
The theme of the story explores the power of perseverance, sacrifice and love. The protagonist, Phoenix Jackson, is at least 80 years old, is battling dementia and other health problems, and is very poor. She overcomes a number of obstacles to retrieve the medicine for her grandson. The fact that her journey is on a worn path also suggests that she has made the trip many times in the past, which she later confirms. Because of her perseverance and sacrifice, she meets her goal and gets the medicine. The primary character in the story is Phoenix.