However, some people who have early-onset Alzheimer's don't have mutations in these three genes. That suggests that this early-onset form of Alzheimer's disease is linked to other genetic mutations that haven't been identified yet.
Early history Cigars, cigarettes Cancer by the carton Legal history Surgeon General's warning. (CNN) -- Tobacco was first used by the peoples of the pre-Columbian Americas. Native Americans apparently cultivated the plant and smoked it in pipes for medicinal and ceremonial purposes.
Americaâs First Cash Crop: Tobacco. The year was 1614, and the sailing ship Elizabeth was setting off from the young English colony of Jamestown, bound for London with a cargo that included four barrels of tobacco, about 4,000 pounds. Few probably knew thatthose four barrels would change the entire economy of Virginia in less than a decade.