What is it: A Process Control Plan (PCP) is a summary of defect prevention and reactive detection techniques. The overall intent of the PCP is to control the product characteristics and the associated process variables to ensure capability (around the identified target or nominal) and stability of the product over time.
Various compounds can reduce the activity of enzymes. They may act in a variety of different ways, and indeed may be reversible or irreversible inhibitors of the enzyme. An irreversible inhibitor causes covalent modification of the enzyme, so that its activity is permanently reduced.
COX-1 protects the stomach from ulcers, and COX-2 is a protein that, among other things, causes joint inflammation. COX-2 inhibitors are NSAIDs designed to focus on the blockage of the COX-2 enzyme. COX-2 inhibitor drugs are called âselective inhibitorsâ because they only block the COX-2 protein and not COX-1. Both selective and non-selective NSAIDs can help with pain and inflammation, but side-effects such as stomach upset or ankle swelling can be problems, and cardiovascular side-effects have been described. see also Medication.