However, some people who have early-onset Alzheimer's don't have mutations in these three genes. That suggests that this early-onset form of Alzheimer's disease is linked to other genetic mutations that haven't been identified yet.
Early history Cigars, cigarettes Cancer by the carton Legal history Surgeon General's warning. (CNN) -- Tobacco was first used by the peoples of the pre-Columbian Americas. Native Americans apparently cultivated the plant and smoked it in pipes for medicinal and ceremonial purposes.
However, tobacco did not become widely used in Europe until the middle of the 16th century, when explorers and diplomats such as France's Jean Nicot (for whom nicotine was named) popularized its use. Tobacco was introduced to France in 1556, Portugal in 1558, Spain in 1559, and England in 1565. Initially, tobacco was produced for pipe smoking, chewing and snuff. Cigarettes were made in a crude, hand-rolled form since the early 1600s, but did not become popular in America until after the civil war.