However, some people who have early-onset Alzheimer's don't have mutations in these three genes. That suggests that this early-onset form of Alzheimer's disease is linked to other genetic mutations that haven't been identified yet.
Early history Cigars, cigarettes Cancer by the carton Legal history Surgeon General's warning. (CNN) -- Tobacco was first used by the peoples of the pre-Columbian Americas. Native Americans apparently cultivated the plant and smoked it in pipes for medicinal and ceremonial purposes.
In England, the first consignments of Virginia tobacco for pipe smoking had arrived and some 7,000 shops in London sold tobacco by 1615. By 1618 the Thirty Years War contributed to the popularity of smoking, and in 1619, the first Africans were taken to Virginia.