Acetylcholine is released from a presynaptic neuron into the synaptic cleft. Once in the synaptic gap, acetylcholine can: - Bind to presynaptic receptors: presynaptic activation or inhibition leads to automodulation of the presynaptic cholinergic neuron.
When welts are a sign of a medical problem, they are usually accompanied by other symptoms which provide clues to the problem. Physical trauma such as a blow can cause a welt, and welts can also be caused by allergic reactions, infections, injections, insect bites, and skin reactions, in very sensitive people. For example, in people with dermographism, even a gentle touch to the skin can cause a welt to emerge.
Blood disorders such as hemophilia and leukemia can cause unexplained bruising, often because your blood fails to clot properly. If you have severe and frequent unexplained bruising, it's a good idea to see a physician to rule out such disorders, especially if it seemed to come on suddenly.y Dr. Mercola. Any type of traumatic injury, such as a fall, can cause capillaries (small blood vessels) near your skin's surface to break and leak red blood cells. This causes the reddish-purple or black and blue appearance of bruises on your skin.