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The development of each chain is controlled at a separate genetic locus. Changes in the amino acid sequence of these chains results in abnormal hemoglobins. For example, hemoglobin S is found in sickle-cell disease, a severe type of anemia in which the red cells become sickle-shaped when oxygen is in short supply.
A test used to monitor the health of patients with diabetes. The HgBA1c test is a useful tool for monitoring the overall stability of the patient's blood glucose. When blood glucose levels are elevated, the glucose molecules bind with hemoglobin to form HgBA1c.