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1: How does ecstasy work: serotonin pathways in the brain. The nerve pathway that is predominantly affected by ecstasy is called the serotonin pathway. Serotonin is a neurotransmitter that is synthesized, stored, and released by specific neurons in this pathway.It is involved in the regulation of several processes within the brain, including mood, emotions, aggression, sleep, appetite, anxiety, memory, and perceptions.irst, describe how serotonin pathways innervate (connect to) different brain regions. Point to the cell bodies of the serotonin pathway that are located in the brainstem area the Raphe nucleus in pink).
Activation of 5-HT2 receptors seems to cause serotonin to have an excitatory effect on some neurons. LSD prevents this action, thus having an antagonistic effect on the 5-HT2 serotonin system (12). However, even within this theory there are problems.rolonged use of MDMA results in destruction of serotonergic neurons in the brain (4, 5). Because of the similarities between ecstasy 'trips' and LSD 'trips,' it can be concluded that they must activate a similar pathway, i.e. the serotonergic pathway. Several theories of the mechanism of LSD have been postulated.