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From Wikipedia, the free encyclopedia. The urea cycle (also known as the ornithine cycle) is a cycle of biochemical reactions occurring in many animals that produces urea ((NH2)2CO) from ammonia (NH3). This cycle was the first metabolic cycle discovered (Hans Krebs and Kurt Henseleit, 1932), five years before the discovery of the TCA cycle. In mammals, the urea cycle takes place primarily in the liver, and to a lesser extent in the kidney.
Urea or carbamide is an organic compound with the chemical formula C O (N H 2) 2. The molecule has two âNH 2 groups joined by a carbonyl (C=O) functional group.Urea serves an important role in the metabolism of nitrogen-containing compounds by animals, and is the main nitrogen-containing substance in the urine of mammals.It is colorless, odorless solid, highly soluble in water, and practically non-toxic (LD50 is 15 g/kg for rats).rea production occurs in the liver and is regulated by N-acetylglutamate. Urea is then dissolved into the blood (in the reference range of 2.5 to 6.7 mmol/liter) and further transported and excreted by the kidney as a component of urine.