However, some people who have early-onset Alzheimer's don't have mutations in these three genes. That suggests that this early-onset form of Alzheimer's disease is linked to other genetic mutations that haven't been identified yet.
Early history Cigars, cigarettes Cancer by the carton Legal history Surgeon General's warning. (CNN) -- Tobacco was first used by the peoples of the pre-Columbian Americas. Native Americans apparently cultivated the plant and smoked it in pipes for medicinal and ceremonial purposes.
In 1843, the French Monopoly began the manufacture of cigarettes, a form of tobacco consumption which up until then had a reputation as âbeggarâsâ smokesâ based upon the cheap smokes made from discarded cigar scraps in neighboring Seville, Spain for hundreds of years.