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An E-box (enhancer box) is a DNA response element found in some eukaryotes that acts as a protein-binding site and has been found to regulate gene expression in neurons, muscles, and other tissues.
IBM SilverPop. On the Internet, E2E has been used to mean exchange-to-exchange-that is, the exchange of information or transactions between Web sites that themselves serve as exchanges or brokers for goods and services between businesses.