If not corrected, blood flow in the penis becomes impeded by the increasingly constricting band of foreskin, which causes further swelling of the glans. Because lack of oxygen from the reduced blood flow can cause tissue death (necrosis), paraphimosis is considered a medical emergency and requires immediate treatment.
Allantoin is a major metabolic intermediate in many other organisms including plants and bacteria.llantoin is a major metabolic intermediate in many other organisms including plants and bacteria.
It is favorably mentioned back in Turner's Herball of 1568, Gerard's Herball of 1597, Parkinson's 1640 Theatrum Botanicum, and Tournefort's 1719 Compleat Herbal. There have been monographs on comfrey throughout the centuries, and one of the active ingredients, allantoin, is found in salves and lotions today..