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Biochemistry of Dog Coat Color. The color of a dogâs coat is determined by relative levels of two pigments: eumelanin, which can be either brown or black, and pheomelanin, which is yellow to orange or red. Both pigments are generated by metabolism of tyrosine. A schematic diagram of the pathway is below. Schematic of the melanin synthesis pathways.
For an overview of dog coat color hierarchy continue to the article Introduction into coat color in dogs. ASIP gene (Agouti signal peptide). The expression of the locus A is affected by the loci E and K. The locus A is not expressed in the presence of KB allele and the genotype e/e.These alleles are epistatic to the locus A alleles.he expression of the locus A is affected by the loci E and K. The locus A is not expressed in the presence of KB allele and the genotype e/e.