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Thrombophilia (sometimes hypercoagulability or a prothrombotic state) is an abnormality of blood coagulation that increases the risk of thrombosis (blood clots in blood vessels).
1 Damage to the inside of a blood vessel due to trauma or other conditions. 2  Changes in normal blood flow, including unusual turbulence, or partial or complete blockage of blood flow.  Hypercoagulability, a rare state in which the blood is more likely than usual to clot.