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Creatinine is a metabolic by-product of muscle metabolism, and normally appears in urine in relatively constant quantities over a 24 hour period with normal liquid intake. Therefore, urine creatinine can be used as an indicator of urine water content or as a marker identifying a specimen as urine. Greater than normal intake of water will increase the urine water content (lowering the creatinine level) consequently diluting the amount of drug in urine. Conversely, a limited intake of water can lead to an abnormally concentrated urine specimen (as occurs with dehydration) resulting in elevated creatinine levels.
High levels of creatinine may indicate that your kidney is damaged and not working properly. Creatinine blood tests are usually performed along with several other laboratory tests, including a blood urea nitrogen (BUN) test and a basic metabolic panel (BMP) or comprehensive metabolic panel (CMP). These tests are done during routine physical exams to help diagnose certain diseases and to check for any problems with your kidney function.