Ono Pharmaceuticals, Opdivo âs originator, has negotiated a price of Â¥150,200 ($1,459) per 20mg vial of Opvido, and Â¥729,849 for 100mg.pplying a similar mark-up to Opdivo, as well as accounting for the higher average body weight of 75kg in the US, gives a price for Opdivo of $118,000 per patient per year, if the same assumption is made about time on therapy.
*Philosophes did not support democracy. -George III of England (r. 1760-1820) and Louis XV of France (r. 1715-1774) had no interest in enlightened monarchy. -Catherine the Great of Russia, Frederick the Great of Prussia, and Joseph II of Austria were Europe's best-known enlightened despots.
Theodore Roosevelt derisively named them for the Man with the Muck Rake,  a figure who would rake to himself the filth of the floor in John Bunyan's Pilgrim's Progress.49 The muckrakers were reporters, authors, and critics who sought to expose the evils and injustices of Gilded Age society, hoping to expose such social ills before they strangled democracy.