Confidence votes 11. According to Wikipedia, the width of the Atlantic Ocean at its narrowest point is 2,848 kilometers (1,770 mi) between Brazil and Sierra Leone.
What causes PNH? It is not fully understood why people develop PNH. Inside the bone marrow, blood cells are made by stem cells (the seed cells of the marrow). PNH occurs due to a change (or mutation) in a gene in one of the stem cells in the bone marrow. This mutation happens in a gene called PIG-A and the cells made by this stem cell lack certain proteins on their surface making them âweakerâ than normal blood cells.
Symptoms and Treatments of Peripheral Nerve Hyper-excitability. The primary symptoms caused by PNH is involuntary muscle fibre activity such as twitches, cramp and cramp like feelings together with muscular aches and pains, soreness and discomfort.Some people may also experience sleep disturbance and fatigue.iseases that cause Hyper-excitability. Peripheral nerve hyperexcitability (PNH) is any disorders associated with twitching spasms, spontaneous muscular activities, facial tics etc.