Melania Trump. Melania Trump (born Melanija Knavs [mÉËlaËnija ËknaËuÌ¯s], April 26, 1970; Germanized to Melania Knauss) is the First Lady of the United States, married to President Donald Trump.
Rectal administration uses the rectum as a route of administration for medication and other fluids, which are absorbed by the rectum's blood vessels, and flow into the body's circulatory system, which distributes the drug to the body's organs and bodily systems.n addition, the rectal route bypasses around two thirds of the first-pass metabolism as the rectum's venous drainage is two thirds systemic (middle and inferior rectal vein) and one third portal (superior rectal vein).
1. Rectal administration is commonly used though not well studied. Both regular and sustained release opioids can be given rectally. This may be a useful alternative for patients who cannot take oral medication, especially in the active dying phase. The dosing is 1:1 with the oral medication used previously. Absorption and effect may vary according to how high the suppository is placed-the lower area is drained by veins that do not enter the hepatic venous system and thus avoid the first-pass effect. This consideration is not usually of clinical significance.