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1 A biologic is manufactured in a living system such as a microorganism, or plant or animal cells. 2  Most biologics are very large, complex molecules or mixtures of molecules.
Moderate to Severe Psoriasis and Psoriatic Arthritis: Biologic Drugs. Biologic drugs, or biologics, are given by injection or intravenous (IV) infusion. A biologic is a protein-based drug derived from living cells cultured in a laboratory. While biologics have been used to treat disease for more than 100 years, modern-day techniques have made biologics much more widely available as treatments in the last decade.