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Biochemistry of Dog Coat Color. The color of a dogâs coat is determined by relative levels of two pigments: eumelanin, which can be either brown or black, and pheomelanin, which is yellow to orange or red. Both pigments are generated by metabolism of tyrosine. A schematic diagram of the pathway is below. Schematic of the melanin synthesis pathways.
The K locus plays a pivotal role in coat color. This locus is a relative newcomer in our understanding of canine color, and includes traits formerly attributed by some to other genes. The dominant allele in the series is K B, which is responsible for self-coloring, or solid colored fur in pigmented areas.t is also responsible for nose color. The gene associated with this locus is known as TYRP1. In breeds where the A locus does not come into play, any animal that has at least one B allele (and is not ee), will be black in pigmented coat. Those dogs, which have two copies of any of several b alleles will be brown.