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Biochemistry of Dog Coat Color. The color of a dogâs coat is determined by relative levels of two pigments: eumelanin, which can be either brown or black, and pheomelanin, which is yellow to orange or red. Both pigments are generated by metabolism of tyrosine. A schematic diagram of the pathway is below. Schematic of the melanin synthesis pathways.
In some breeds dogs that are (S/S) are completely white while dogs that are (n/S) have what is referred to as mantle. As with horses and other animals, dog breeds with white spotting patterns can be affected by additional mutations in MITF and or other genes that effect coat color deletion and distribution. For example, the irish spotting pattern seen in many breeds of dogs (such as Collies) is not caused by this mutation.