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Biochemistry of Dog Coat Color. The color of a dogâs coat is determined by relative levels of two pigments: eumelanin, which can be either brown or black, and pheomelanin, which is yellow to orange or red. Both pigments are generated by metabolism of tyrosine. A schematic diagram of the pathway is below. Schematic of the melanin synthesis pathways.
This form of the gene is represented as the e allele. The e allele is recessive, meaning that a dog must have two copies of the MC1R mutation to express the yellow or red coat color.Recessive red can mask other color variants even masking merle.ther breeds express the ee phenotype as a red color. It is important to note that the extension gene is only one of four important genes in determining the coat color of a canine. The dog's color can vary greatly with different mutated alleles on other genes.