Cell Wall & Gram classification â¢ Most bacteria fall into one of two groups: Gram-positive or Gram-negative â¢ Based on results of a differential staining test (the Gramâs stain) â¢ Primary basis for this distinction is differences in their cell walls Cell Wall: structure & composition Peptidoglycan (murein) â¢ Most importantcomponent
Chlorhexidine is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. The physiologic effect of chlorhexidine is by means of Decreased Cell Wall Integrity. Chlorhexidine is a biguanide compound used as an antiseptic agent with topical antibacterial activity.
FDA Pharmacology Summary from FDA Pharm Classes. Chlorhexidine is a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine penetrates into the cell and causes leakage of intracellular components leading to cell death.