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Biochemistry of Dog Coat Color. The color of a dogâs coat is determined by relative levels of two pigments: eumelanin, which can be either brown or black, and pheomelanin, which is yellow to orange or red. Both pigments are generated by metabolism of tyrosine. A schematic diagram of the pathway is below. Schematic of the melanin synthesis pathways.
A dog's eye color is determined by the amount of melanin found in the iris. Brown eyes indicate a high concentration of melanin, while green or blue eyes indicate a lower amount. Dogs with two different colored eyes have differing melanin levels in each eye. Heterochromia, however, can also be centralized. That is, the iris of one eye can be two different colors.