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Treatment side effects. A wide range of medication can cause a metallic taste in the mouth as a side effect. Examples are: 1  antibiotics (such as metronidazole). 2  antifungal medicine. 3  antihistamines. 4  chemotherapy. 5  diuretics. 6  steroid medication. 7  nicotine patches.
Dysgeusia can cause a number of different alterations in taste, including a metallic taste. Some common medical conditions that can cause metallic taste in the mouth include ear or upper respiratory infections such as sinusitis, as well as head injury or conditions that damage the central nervous system (CNS). A history of radiation therapy to the head and neck can also cause a metallic taste in the mouth.