Seen as quite offensive for some, especially older groups and British Asian females, with its sexual connotations. For others it is seen as a middle of the road sort of word. Most offensive word to majority, and never really acceptable (though some might occasionally use).
Cyclins go hand in hand with kinases. Cyclins do not cause a cell to progress in the cell cycle because cyclins are mere proteins that regulate the rate of the process, and how fast the cell progresses through this process. Cyclins also act by binding to various kinases, which are enzymes that transfer a phosphate group from ATP to other enzymes. The phosphate group activates these enzymes. The quantity of these kinases in the cell remains steady throughout the cell cycle; however they are active only when bound to cyclins.
A cyclin-dependent kinase inhibitor (CKI) is a protein that interacts with a cyclin-CDK complex to block kinase activity, usually during G1 or in response to signals from the environment or from damaged DNA. In animal cells, there are two major CKI families: the INK4 family and the CIP/KIP family.he structure of human Cdk2 revealed that CDKs have a modified ATP-binding site that can be regulated by cyclin binding. Phosphorylation by CDK-activating kinase (CAK) at Thr 161 on the T-loop increases the complex activity.