Side Effects. Side effects are rare; still symptoms like ear irritation, acute inflammation of the ear canal and pinna are reported. In some cases the pet might experience lack of appetite, vomiting, diarrhea, or hearing loss during the course of treatment, which might require immediate medical aid.
Furthermore, if the median age of a marathon participant is about 40, then the average maximum heart rate of a U.S. marathoner is about 180. Seventy percent of 180 is 126, while 80 percent is 144. Therefore, the heart rate of a mid-pack runner during a marathon is near the middle of the range -- between 126 and 144, or 135 beats per minute.
A normal resting heart for average adults is anywhere from 60 to 100 beats per minute, or BPM. If you happen to be very active or an athlete in training, your resting heart rate might be even lower, around 40 BPM, because exercise makes your heart stronger and more efficient at delivering oxygenate blood to your cells.