Medical Dictionary. arrhythmia. play. noun arÂ·rhythÂ·mia \Ä-Ërith-mÄ-É\. Medical Definition of arrhythmia. : an alteration in rhythm of the heartbeat either in time or force.
Central metabolism provides mechanisms for the generation of energy from carbon-energy source catabolism and the production of biosynthetic precursors and intermediates for the anabolic pathways essential to maintain cell structure and function.
The metabolism of irinotecan (CPT-11). CPT-11 is converted into the active anti-tumour compound SN-38 by carboxyl esterase. Glucuronidation of SN-38 by UGT1A1 results in the non-toxic SN-38 glucuronide that is excreted into bile and urine.