Side Effects. Side effects are rare; still symptoms like ear irritation, acute inflammation of the ear canal and pinna are reported. In some cases the pet might experience lack of appetite, vomiting, diarrhea, or hearing loss during the course of treatment, which might require immediate medical aid.
Furthermore, if the median age of a marathon participant is about 40, then the average maximum heart rate of a U.S. marathoner is about 180. Seventy percent of 180 is 126, while 80 percent is 144. Therefore, the heart rate of a mid-pack runner during a marathon is near the middle of the range -- between 126 and 144, or 135 beats per minute.
An average heart beats about 100,000 times daily. A pulse rate is measured in the amount of beats in one minute. At rest, a pulse averages 70 to 80 beats per minute. Endurance athletes can have a resting pulse as low as 40 beats per minute. People that are overweight, sedentary or smokers often have a resting pulse of 90 beats per minute. A pulse is established by the heart's own pacemaker.