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Treatment side effects. A wide range of medication can cause a metallic taste in the mouth as a side effect. Examples are: 1  antibiotics (such as metronidazole). 2  antifungal medicine. 3  antihistamines. 4  chemotherapy. 5  diuretics. 6  steroid medication. 7  nicotine patches.
Medications Are a Leading Cause. Medications are the leading cause of experiencing that metal-like taste. This should not come as a surprise, since there are so many different chemicals and compounds, both organic and inorganic, which might be present in the medications you are taking.