A dose of 0.5 milligrams of melatonin has been taken under the tongue for six days. For seizure disorders, doses of melatonin taken by mouth were 3-10 milligrams daily for 2-4 weeks to three months. For sleep (general), doses of melatonin taken by mouth were 0.3-10 milligrams.
The degradation of the synthetic, amphoteric surfactant, cocamidopropyl betaine (CAPB) and its toxicity to the marine macroalga, Ulva lactuca, has been evaluated using several different physiological test end-points over different periods of exposure up to 120 h.ell membrane damage, estimated from measurements of ion leakage, was detected only at a concentration of 40 mg l(-1) after 48 h of exposure to CAPB but by 120 h damage was evident at all measured concentrations above 10 mg l(-1).
In one OECD 414 study cocamidopropyl betaine showed no teratogenic potential, even at maternal-toxic doses. Embryotoxicity was noted at the highest maternal-toxic dose in one study. The NOAEL for dams was 333 mg/kg bw (95 mg active substance/kg bw) and 990 mg/kg bw (286 mg active substance/kg bw) for the fetuses.0 male and female rats were administered 1.92 ml cocamidopropyl betaine/kg bw (corresponding to 2000 mg/kg bw 31 % active substance) for 24 h under occlusive conditions. 10 % of the total body surface was covered. No deaths occurred during 14 days post-dose observation period.