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Creatinine is a metabolic by-product of muscle metabolism, and normally appears in urine in relatively constant quantities over a 24 hour period with normal liquid intake. Therefore, urine creatinine can be used as an indicator of urine water content or as a marker identifying a specimen as urine. Greater than normal intake of water will increase the urine water content (lowering the creatinine level) consequently diluting the amount of drug in urine. Conversely, a limited intake of water can lead to an abnormally concentrated urine specimen (as occurs with dehydration) resulting in elevated creatinine levels.
Low creatinine clearance levels in the urine detected through creatinine blood test is one of the symptoms of chronic liver diseases such as cirrhosis. A. Creatinine blood test is performed to check kidney function. One of the important parameters used to determine the efficacy of kidney function and to detect symptoms of kidney disease, chronic disease, or other conditions is the results of creatinine blood test.