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Thrombophilia (sometimes hypercoagulability or a prothrombotic state) is an abnormality of blood coagulation that increases the risk of thrombosis (blood clots in blood vessels).
Hyperparathyroidism is the internal disruption that leads to the physical signs we label as Metabolic Bone Disease. Frugivorous reptiles like crested geckos are especially susceptible to MBD because of improper supplementation and the use of baby food.