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Quick Answer. Hiccups resulting from surgery may be caused by a reaction to anesthesia or happen as a result of abdominal surgery or medical procedures such as a tracheotomy, states Healthline. Using a catheter to access the heart, bronchoscopy or using a stent in the esophagus can also result in long-term hiccups.
To understand how medications can cause hiccups, it helps to know the mechanism of hiccups themselves. Hiccups are a series of interactions between several nerves in the central nervous system, the diaphragm and abdominal muscles, and the glottis--the opening between the vocal cords.