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Biochemistry of Dog Coat Color. The color of a dogâs coat is determined by relative levels of two pigments: eumelanin, which can be either brown or black, and pheomelanin, which is yellow to orange or red. Both pigments are generated by metabolism of tyrosine. A schematic diagram of the pathway is below. Schematic of the melanin synthesis pathways.
There are three versions, or alleles, of the K locus: K B, k br, and k y. If a dog has even a single copy of K B (K B K B, K B k y, K B k br) it will be solid colored in the pigmented areas, and we go directly to the B locus to determine color.t is also responsible for nose color. The gene associated with this locus is known as TYRP1. In breeds where the A locus does not come into play, any animal that has at least one B allele (and is not ee), will be black in pigmented coat. Those dogs, which have two copies of any of several b alleles will be brown.