President Hooverâs inactivity and belief in waiting things out left the United States in economic turmoil and in search of a new more dynamic leader. That leader was Franklin Delano Roosevelt who took over the presidency on January 20, 1933.
The mechanism of diltiazem hepatotoxicity is not known, but most cases are probably due to hypersensitivity. Diltiazem is metabolized by the cytochrome P450 system and is an inhibitor of CYP 3A4 activity, which can lead to serious drug-drug interactions and potentiation of the hepatotoxic effects of other medications.
Diltiazem products on the Saskatchewan Drug Plan formulary1. Diltiazem CD capsule 120 mg, 180 mg, 240 mg, 300 mg. Reference product = Cardizem CD, various generics (often denoted as diltiazem CD) Release mechanism: encapsulated beads2. Diltiazem ER capsule 120 mg, 180 mg, 240 mg, 300 mg, 360 mg. Reference product = Tiazac, various generics (often denoted as diltiazem T) Release mechanism: âdrug-pasteâ is converted into small immediate release beads, which are then. coated with a rate-controlling polymer.3.