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Hypercoagulable state: A hypercoagulable state is the medical term for a condition in which there is an abnormally increased tendency toward blood clotting (coagulation). There are numerous hypercoagulable states.
The best clue for the presence of hypercoagulability is a positive family history. Clinical suspicions occur when patients are seen with unexpected venous thromboembolic disease, recurrent thrombosis, or thrombosis at unusual sites, such as the brain, portal vein, or hepatic vein.n addition, this entity should be considered in cases of unanticipated arterial occlusive disease of the central nervous system, extremities, mesenteric vessels, or cardiac tree. The defects that are responsible for hypercoagulability can be divided into inherited defects and acquired forms.