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Phenylketonuria Definition: Phenylketonuria (PKU) is a genetic disorder that is characterized by an inability of the body to utilize the essential amino acid, phenylalanine.henylketonuria Definition: Phenylketonuria (PKU) is a genetic disorder that is characterized by an inability of the body to utilize the essential amino acid, phenylalanine.
Phenylketonurics is the term used to refer to people that have the metabolic disorder Phenylketonuria, or PKU for short. I myself, am one of these phenylketonurics and the warning on diet soda cans is included merely to inform people like me that the product contains aspartame. People that have the disorder PKU cannot consume any product that contains aspartame, for reasons which I will elaborate on below.