An archive is an accumulation of historical records or the physical place they are located.[1] Archives contain primary source documents that have accumulated over the course of an individual or organization's lifetime, and are kept to show the function of that person or organization.
Pfeiffer syndrome is a complex genetic disorder that affects your childâs head, face, hands and feet. Clinical features vary for different children and range from mild to severe. Craniosynostosis: Premature (early) closure of growth plates of the skull that changes the shape of the head and can put increased pressure on the brain.
Another gain-of-function mutation in the FGFR1 gene causes type 1 Pfeiffer syndrome. This condition is characterized by premature fusion of certain bones in the skull (craniosynostosis), which leads to a misshapen head and distinctive facial features. Affected individuals also have hand and foot abnormalities.lterations in the activity (expression) of the FGFR1 gene are associated with certain cancers. The altered gene expression may enhance several cancer-related events such as cell division, cell movement, and the development of new blood vessels that nourish a growing tumor.