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Treatment side effects. A wide range of medication can cause a metallic taste in the mouth as a side effect. Examples are: 1  antibiotics (such as metronidazole). 2  antifungal medicine. 3  antihistamines. 4  chemotherapy. 5  diuretics. 6  steroid medication. 7  nicotine patches.
Quick Answer. Reactions between chemical compounds on the skin and metals such as iron and copper can generate a metallic smell, explains Nature. A copper imbalance in the body, which triggers excessive yeast growth, can also cause a metallic odor, notes Dr. Lawrence Wilson. Gum disease, also known as periodontal disease, can similarly precipitate a metallic mouth odor, according eMedicineHealth.