Leg weakness most commonly arises from nerve compression in the lower back. Hence, pain in the lower back region should not be ignored, especially if it is longstanding. The shooting pain, which travels from the lower back to the knee or the ankle, is because of the irritation of the nerves caused by compression.
Heart disease is a serious medical condition in dogs, cats and humans. Cats do not normally develop arteriosclerosis or coronary artery disease, which are both common diseases in humans. In general terms, heart disease can be divided into two categories, congenital and adult onset forms.
1 Ehlers-Danlos syndrome, arthrochalasia type is caused by mutations in the COL1A1 gene. 2  The mutations in the COL1A1 gene that cause this disorder instruct the cell to leave out a part of the pro-alpha1(I) chain that contains a segment used to attach one molecule to another. Osteogenesis imperfecta, type IV: Several different types of mutations in the COL1A1 gene cause osteogenesis imperfecta type IV. 2  These mutations may involve missing pieces of the COL1A1 gene or changes in base pairs (the building blocks of DNA).