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There are four key causes of low creatinine: low muscle mass; liver problems; diet; pregnancy or illness; Low muscle mass. Levels of creatinine are often linked with muscle mass or the amount of muscle in the body, which can decrease with age or illness.
What Does Low Creatinine Level Mean. Low creatinine levels usually does not mean harmful causes, but in a few cases, it may indicate the presence of serious medical conditions. If you are undergoing lower creatinine level, it may result from one of the following causes. - Reduced muscle mass. Creatinine is the by products of muscle metabolism. In people who have reduced muscle mass, creatinine levels tend to be low. For patients who have muscular dystrophy or myasthenia gravis, the creatinine levels are always lower than others.