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And then it went away when I started it again. It was better then a drug â¦ and no side affects! (Later, I found out that the sourse cause of the heartburn was a simple vitamine C tablet that I had also been taking.) Just one more thing. John Lee, M.D. also said that magnesium deficiency can cause leg cramps.
Electrolyte Imbalance. The American Academy of Orthopaedic Surgeons explains that leg spasms may be caused by an electrolyte imbalance. Electrolytes are chemicals in the blood that regulate important body functions. When a person sweats during exercise, potassium, calcium and magnesium levels are depleted. Certain medications may also affect the chemical balance of these nutrients, which can create leg spasms. To prevent leg spasms, a patient should eat balanced meals to adequately supply nutrient levels and prevent leg spasms.