Sawako Kuronuma (é»æ²¼ ç½å­ Kuronuma Sawako) is the main protagonist of the series Kimi ni Todoke.
When the intensity, duration, and/or frequency of anxiety become distressful and chronic, such that it interferes with a person's functioning, it is often referred to as pathological anxiety.Anxiety disorders represent variant forms of this pathological anxiety.hese three factors-duration, intensity, and frequency-distinguish normal, adaptive anxiety from abnormal, pathological anxiety. As such, abnormal anxiety is different from normal anxiety because it is disproportionate to the situation that elicited the anxious response.
Several studies have shown that brain chemistry imbalances are a very likely cause of anxiety disorders. This research has shown that those suffering from anxiety often have issues with several neurotransmitters (brain chemicals), including serotonin, norepinephrine and gamma-aminobutyric acid (GABA).