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The CAS Registry Number is similar to a telephone number and has no significance in terms of the chemical nature or hazards of the material. The CAS Registry Number can be used to locate additional information on the material, for example, when searching in books or chemical data bases.
The CRISPR/Cas system is a prokaryotic immune system that confers resistance to foreign genetic elements such as plasmids and phages, and provides a form of acquired immunity. CRISPR spacers recognize and cut these exogenous genetic elements in a manner analogous to RNAi in eukaryotic organisms.CRISPRs are found in approximately 40% of sequenced bacteria genomes and 90% of sequenced archaea.NA-guided CRISPR associated nuclease Cas9 is an effective way of targeting and silencing specific genes at the DNA level In bacteria, the presence of Cas9 alone is enough to block transcription, but for mammalian applications, a section of protein is added.