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Reactive thrombocytosis, also known as secondary thrombocytosis, is the most common cause of elevated platelets. This disorder occurs in response to other diseases or conditions. These may include chronic inflammatory conditions, acute infection, some anemias, cancer, and other blood disorders.
What causes a temporary increase in a platelet count? A: In reactive thrombocytosis, the platelet count is elevated due to another disorder, such as an infection, bleeding, iron deficiency, cancer, destruction of red blood cells, removal of the spleen, inflammatory disease or other blood condition, the Merck Manual states.