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Reactive thrombocytosis, also known as secondary thrombocytosis, is the most common cause of elevated platelets. This disorder occurs in response to other diseases or conditions. These may include chronic inflammatory conditions, acute infection, some anemias, cancer, and other blood disorders.
The exact cause of essential thrombocythemia and similar conditions, known as myeloproliferative disorders, isn't known. About 80 percent of people with the disorder have an acquired gene mutation contributing to the disease.This may involve the Janus kinase 2 (JAK2), calreticulin (CALR) or MPL gene mutation. normal platelet count ranges from 150,000 to 450,000 platelets per microliter of blood. If you have essential, or primary, thrombocythemia, your bone marrow makes too many platelet-forming cells (megakaryocytes).