Aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder in adults, children, and adolescents. Used as maintenance therapy, it is useful for the prevention of manic episodes, but is not useful for bipolar depression.
The enormous population of 23.5 million (23,500,000) is also due to the fact that Karachi is the main business center of, almost, all the corporations in Pakistan. Having population density of 6,663/km2, it is also a main hub of higher education in Muslim world. See Also; 10 Most Dangerous Cities in The World.
With these population figures Karachi is among the 10 largest metropolises in the world. The city extends from the Indus River to the Kirthar mountain range. Until Islamabad became the capital of Pakistan Karachi was the capital. Karachi is still the most important economic centre in the country, many multinationals have settled here over the past few years; also because Karachi is a large port.