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Reactive thrombocytosis, also known as secondary thrombocytosis, is the most common cause of elevated platelets. This disorder occurs in response to other diseases or conditions. These may include chronic inflammatory conditions, acute infection, some anemias, cancer, and other blood disorders.
Pregnancy, autoimmune diseases, an enlarged spleen and bacteria in the blood are reasons for a low platelet count, also known as thrombocytopenia. There are also a few medications that can contribute to low levels, including heparin, sulfa-containing antibiotics, quinine and interferon, explains Mayo Clinic.