The toxic effect is related linearly through a relatively large range of body weights, to the body weight of the victim, and, The mechanism of toxicity is the same for âsimilar animalsâ, i. e. one may conduct toxicity tests on say rats or mice and apply the LD50 data to human, since both are mammals.
For moderate menstrual cramps, the nonsteroidal anti-inflammatory drugs (NSAIDs, such as ibuprofen [Advil, Motrin, Nuprin, etc.] or naproxen [Aleve, Anaprox, Naprosyn, Naprelan]) are often helpful.
As of October 2014, the Midol website lists five unique formulations meant to alleviate cramps and other symptoms that accompany the menstrual period. Midol Complete, available in caplets or gelcaps, contains acetaminophen for pain relief as well as caffeine to alleviate bloating and fatigue. It also includes the antihistamine pyrilamine maleate to combat swelling related to water retention.