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The most common cause of long-term hiccups is damage to or irritation of the vagus nerves or phrenic nerves, which serve the diaphragm muscle.Factors that may cause damage or irritation to these nerves include: 1  A hair or something else in your ear touching your eardrum. 2  A tumor, cyst or goiter in your neck.
Nerve irritation is one of the most common causes of hiccups. The nerve that relays messages to and from the diaphragm muscle is called the phrenic nerve, according to Dr. Williiam Whitelaw, a professor at the University of Calgary. Irritation of the phrenic nerve, either temporary or more permanent, can cause hiccups.