Aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder in adults, children, and adolescents. Used as maintenance therapy, it is useful for the prevention of manic episodes, but is not useful for bipolar depression.
The enormous population of 23.5 million (23,500,000) is also due to the fact that Karachi is the main business center of, almost, all the corporations in Pakistan. Having population density of 6,663/km2, it is also a main hub of higher education in Muslim world. See Also; 10 Most Dangerous Cities in The World.
Karachi is also Pakistan's most cosmopolitan city. Located on the shores of the Arabian Sea, Karachi is a major transportation hub, home to two of Pakistan's largest seaports, the Port of Karachi and Port Bin Qasim, as well as the busiest airport in Pakistan.