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The dosage range for cephalexin (KeflexÂ®) is most often 22 to 33 mg/kg. Great Danes are big dogs as you know (weight range can be 110 to 160 pounds). Let's say your dog weighs a modest 110 pounds. They would be roughly 55 kg. 55 kg x 22 mg/kg = 1210 mg or if they used the 33 mg/kg = 1815 mg.
A Rottweiler, or another 60 pound dog, could get a full aspirin. However, Advil and Aspirin should not be used if your dog has arthritis or osteoarthritis since these have been shown to damage joint cartilage. There are some NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) approved for veterinary use.