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Reactive thrombocytosis, also known as secondary thrombocytosis, is the most common cause of elevated platelets. This disorder occurs in response to other diseases or conditions. These may include chronic inflammatory conditions, acute infection, some anemias, cancer, and other blood disorders.
A high platelet count can be caused by cancer, infections, anemia, and inflammatory diseases including rheumatoid arthritis and inflammatory bowel disease. A high platelet count can lead to excessive, dangerous blood clotting if left untreated. The medical term for a high platelet count is thrombocytosis, a condition in which bone marrow cells produce too many platelets. Thrombocytosis can be either reactive or essential. Reactive thrombocytosis means that a high platelet count is a reaction to inflammation, infection, injury, anemia, or cancer, and essential thrombocytosis indicates that genetic conditions or hormone imbalances are causing irregular platelet formation.