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CISSUS QUADRANGULARIS Side Effects & Safety. Some specific commercial products containing Cissus quadrangularis are POSSIBLY SAFE when taken by mouth appropriately short-term (for up to 6-8 weeks). These products can cause side effects such as headache, intestinal gas, dry mouth, diarrhea, and insomnia.ISSUS QUADRANGULARIS Side Effects & Safety. Some specific commercial products containing Cissus quadrangularis are POSSIBLY SAFE when taken by mouth appropriately short-term (for up to 6-8 weeks). These products can cause side effects such as headache, intestinal gas, dry mouth, diarrhea, and insomnia.
1 Bone defects caused by gum disease. 2  Early research suggests that adding Cissus quadrangularis to a material called hydroxyapatite, which is used in dentistry to treat tissue loss caused by gum disease, does not improve tissue regrowth in people with specific bone defects called periodontal intrabony defects.ISSUS QUADRANGULARIS Side Effects & Safety. Some specific commercial products containing Cissus quadrangularis are POSSIBLY SAFE when taken by mouth appropriately short-term (for up to 6-8 weeks). These products can cause side effects such as headache, intestinal gas, dry mouth, diarrhea, and insomnia.