Aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder in adults, children, and adolescents. Used as maintenance therapy, it is useful for the prevention of manic episodes, but is not useful for bipolar depression.
The enormous population of 23.5 million (23,500,000) is also due to the fact that Karachi is the main business center of, almost, all the corporations in Pakistan. Having population density of 6,663/km2, it is also a main hub of higher education in Muslim world. See Also; 10 Most Dangerous Cities in The World.
The irrigated portions of the plain are densely populated, being the site of many of Pakistan's principal cities, including Lahore, Faisalabad (formerly Lyallpur), Hyderabad, and Multan. Karachi, the nation's chief port, is located west of the irrigated land at a site accessible to oceangoing vessels.