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There are four key causes of low creatinine: low muscle mass; liver problems; diet; pregnancy or illness; Low muscle mass. Levels of creatinine are often linked with muscle mass or the amount of muscle in the body, which can decrease with age or illness.
High blood pressure and diabetes are two leading cause of kidney disease and kidney failure and of cause they are the major causes of elevated creatinine in the blood. If your creatinine is high, it is very necessary to measure your blood pressure and blood sugar.owever if high creatinine is persistent or if creatinine is much higher than the normal range, it is mostly caused by kidney problems because kidneys are the organs to discharge creatinine from the blood and discharge it through urination.