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The dosage range for cephalexin (KeflexÂ®) is most often 22 to 33 mg/kg. Great Danes are big dogs as you know (weight range can be 110 to 160 pounds). Let's say your dog weighs a modest 110 pounds. They would be roughly 55 kg. 55 kg x 22 mg/kg = 1210 mg or if they used the 33 mg/kg = 1815 mg.
If you're unsure what's causing your dog's itchy ears, you'll want to get him some relief until you can determine the problem. You can give your dog 2 mg of a common antihistamine, like diphenhydramine, for every kilogram of body weight. Usually these are tablets given orally, three times a day.