Qualitative and quantitative factor deficiencies can affect the function of the coagulation pathways. Factor V and factor II (prothrombin) mutations are examples of qualitative deficiencies and are the most common inherited predisposing factors for blood clots.
Definition. A comma splice is a run on sentence, where two or more independent clauses are 'spliced' or split by a comma. A comma splice is considered a significant English error.
Quite simply, a comma splice is the attempt to join two independent clauses with a comma, but without a coordinator. Let's back up for a moment. First of all, according to the definition most of you learned in grade school, an independent clause is one that can stand alone as a sentence.