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1 GAPDH was identified as a binding protein on the plasma membrane of CEM-SS leukemia cells for Bt18 parasporal protein. 2  The study demonstrated that GAPDH is reliable as reference gene for quantitative gene expression analysis in human diploid fibroblasts. GAPDH is an integral part of the sarcolemmal K(ATP)-channel protein complex, where it couples glycolysis with the K(ATP)-channel activity. 2  A decrease in the dehydrogenase activity of GAPDH was noted in Alzheimer disease.
DMD, the largest known human gene, provides instructions for making a protein called dystrophin. This protein is located primarily in muscles used for movement (skeletal muscles) and in heart (cardiac) muscle. Small amounts of dystrophin are present in nerve cells in the brain.he damaged cells weaken and die over time, causing the characteristic muscle weakness and heart problems seen in Duchenne and Becker muscular dystrophy. Genetics Home Reference provides information about familial dilated cardiomyopathy, which is also associated with changes in the DMD gene.