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There are four key causes of low creatinine: low muscle mass; liver problems; diet; pregnancy or illness; Low muscle mass. Levels of creatinine are often linked with muscle mass or the amount of muscle in the body, which can decrease with age or illness.
Diet is another factor that can cause fluctuation of serum creatinine, but it does not cause persistent high creatinine level. People who eat lots of meats suddenly may experience elevation of creatinine level, but it usually go back to the normal range after kidneys discharge excess creatinine in blood.