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The dosage range for cephalexin (KeflexÂ®) is most often 22 to 33 mg/kg. Great Danes are big dogs as you know (weight range can be 110 to 160 pounds). Let's say your dog weighs a modest 110 pounds. They would be roughly 55 kg. 55 kg x 22 mg/kg = 1210 mg or if they used the 33 mg/kg = 1815 mg.
if you have a severe allergy to penicillin or suspect you may do not take keflex. i too am allergic to penicillin and also am allergic to keflex. if someone is allergic to one they are usually allergic to the other because they are a derivitive of each other, meaning they are both penicillan basically.