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There are four key causes of low creatinine: low muscle mass; liver problems; diet; pregnancy or illness; Low muscle mass. Levels of creatinine are often linked with muscle mass or the amount of muscle in the body, which can decrease with age or illness.
1 Certain drugs (for example, cimetidine [Bactrim]) can sometimes cause abnormally elevated creatinine levels.  Serum creatinine can also transiently increase after ingestion of a large amount of dietary meat; thus, nutrition can sometimes play a role in creatinine measurement.