1.) lipid peroxidation - destruction of polyunsat fats -> membrane damage and increased permeability. 2.) attacking critical proteins that affect ion pumps and transport mechanisms. 3.) fragmenting DNA - causing decreased protein synthesis. 4.) damaging mitochondria - causing the liberation of calcium into the cytosol.
Baby Aspirin May Be Best for Heart. May 8, 2007 -- Baby aspirin may be the best aspirin dose for heart health, according to a new research review. A single pill of baby aspirin contains 81 milligrams of aspirin. That's about a quarter of the 325-milligram dose in an adult aspirin pill. The new research review states that in the U.S., the most commonly prescribed aspirin dose for heart health is 81 milligrams per day. The review shows that aspirin doses greater than 81 milligrams per day haven't been proven better than baby aspirin for the heart and may increase the chances of stomach bleeding.
Aspirin is used to treat headaches of all sizes, to suppress minor body aches and pains, and to reduce inflammation when we're sore. But it's rough on the upper digestive tract (can cause upset stomach, heartburn, and even dyspepsia), it's bad for hemophiliacs, and it's not safe for kids. Ibuprofen, sold as Motrin or Advil, is chemically similar to regular aspirin and functions in a similar way. In lower doses, ibuprofen seems to irritate the esophagus and stomach lining less than aspirin and naproxen. If you have ulcers or acid reflux disease, ibuprofen may be the best product for pain clearly resulting from inflammation (arthritis, sprains, sunburns, etc.).