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Penile Discharge Fact Sheet Save this for later. Table of Contents. Penile discharge is the abnormal loss of fluid that is not urine or semen from the urethra at the tip of the penis. It is commonly the sign of a sexually transmitted disease (STD), and requires prompt and accurate diagnosis and treatment.
In men, HPV can also cause cancer of the penis. HPV infection is found in about 6 out of 10 penile cancers. Itâs more common in men with HIV and those who have sex with other men. Thereâs no approved screening test to find early signs of penile cancer.