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There are four key causes of low creatinine: low muscle mass; liver problems; diet; pregnancy or illness; Low muscle mass. Levels of creatinine are often linked with muscle mass or the amount of muscle in the body, which can decrease with age or illness.
Other conditions that cause BUN-to-creatinine ratio to rise are kidney disease, kidney stones, or bleeding in the intestines. Low BUN-to-creatinine can occur in pregnancy, liver disease, or a diet low in protein. The BUN-to-creatinine ratio is not a precise or reliable test, though. It may often be somewhat abnormal in healthy people. More important is the creatinine level itself; if itâs elevated, the kidneys are not working properly, and the reason should be sought out.