Aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder in adults, children, and adolescents. Used as maintenance therapy, it is useful for the prevention of manic episodes, but is not useful for bipolar depression.
Pakistan's 2nd most populous city, Lahore, is only about half the size, with just 6.3 million people, but is still the world's 15th most populous city. Pakistan has six additional cities that have passed the one million population mark.
With these population figures Karachi is among the 10 largest metropolises in the world. The city extends from the Indus River to the Kirthar mountain range. Until Islamabad became the capital of Pakistan Karachi was the capital. Karachi is still the most important economic centre in the country, many multinationals have settled here over the past few years; also because Karachi is a large port.