Aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder in adults, children, and adolescents. Used as maintenance therapy, it is useful for the prevention of manic episodes, but is not useful for bipolar depression.
Pakistan's 2nd most populous city, Lahore, is only about half the size, with just 6.3 million people, but is still the world's 15th most populous city. Pakistan has six additional cities that have passed the one million population mark.
With an estimated population of between 15 and 23.5 million people in its greater metropolitan region, Karachi is considered to be the second-largest city in the Muslim world, and is the world's 7th most populous urban agglomeration.