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The oversight committees, particularly the HPSCI, became increasingly alarmed over the role US intelligence agencies were playing in the implementation of the administration's Central American policy. The issue of greatest concern was the CIA's support to the Contra rebels in Nicaragua.
The Hypothalamic - Pituitary - Adrenal (HPA) Axis And Stress. In response to a stress, the brain region known as the hypothalamus releases corticotropin releasing hormone, or CRH. In turn, CRH acts upon the pituitary gland, causing it to release another hormone, adrenocorticotropin (ACTH). Next, the ACTH triggers the adrenal glands, which reside atop the kidneys, to release corticosteroids, such as cortisol. These compounds include epinephrine (formerly known as adrenaline) and cortisol.