LATUDA is used to treat patients with: 1  Depressive episodes in bipolar I disorder (bipolar depression) when used alone or with lithium or valproate in adults. 2  Schizophrenia in adults and adolescents 13 to 17 years of age.
2 January 2014. Many of the worst train accidents in history occurred in the early 20th and 21st centuries, a testament to the march of technology and the importance of railway safety. The causes behind most of these disasters could be nailed down to brake failures, derailments or accidental fires.
The advent of the steam locomotive and railroad also saw the start of major pollution caused by big business, which is all too often seen today. Polluted rivers and smoke-filled air began to dominate cities, which in turn created poor living and working conditions that gave rise to socialism.