Qualitative and quantitative factor deficiencies can affect the function of the coagulation pathways. Factor V and factor II (prothrombin) mutations are examples of qualitative deficiencies and are the most common inherited predisposing factors for blood clots.
Definition. A comma splice is a run on sentence, where two or more independent clauses are 'spliced' or split by a comma. A comma splice is considered a significant English error.
However, when the occasion clearly calls for either a split infinitive or a preposition at the end of the sentence, I say go for it. But even when a properly handled comma splice would produce just the rhetorical effect I am after, I won't use it. No doubt you are disappointed in me.