Aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder in adults, children, and adolescents. Used as maintenance therapy, it is useful for the prevention of manic episodes, but is not useful for bipolar depression.
Pakistan's 2nd most populous city, Lahore, is only about half the size, with just 6.3 million people, but is still the world's 15th most populous city. Pakistan has six additional cities that have passed the one million population mark.
Karachi is also Pakistan's most cosmopolitan city. Located on the shores of the Arabian Sea, Karachi is a major transportation hub, home to two of Pakistan's largest seaports, the Port of Karachi and Port Bin Qasim, as well as the busiest airport in Pakistan.