2. in psychiatry, an unconscious defense mechanism in which unacceptable ideas, fears, and impulses are thrust out or kept out of consciousness. 3. gene r. enzyme repression interference, usually by the endproduct of a pathway, with synthesis of the enzymes of that pathway. gene repression the inhibition of gene transcription of an operon; in prokaryotes repressor binding to the operon is involved.
The ratio of intracellular to extracellular potassium determines neuromuscular and cardiovascular excitability, which is why serum potassium is normally regulated within a narrow range of 3.5 to 5.0 mmol/L. Dietary K+ intake is highly variable, ranging from as low as 40 mmol/day to more than 100 mmol/day.
The effect of this signaling of high extracellular calcium results in an intracellular calcium concentration that inhibits the secretion of preformed PTH from storage granules in the parathyroid gland. In contrast to the mechanism that most secretory cells use, calcium inhibits vesicle fusion and release of PTH.