Qualitative and quantitative factor deficiencies can affect the function of the coagulation pathways. Factor V and factor II (prothrombin) mutations are examples of qualitative deficiencies and are the most common inherited predisposing factors for blood clots.
Definition. A comma splice is a run on sentence, where two or more independent clauses are 'spliced' or split by a comma. A comma splice is considered a significant English error.
An example of a run-on is a comma splice, in which two independent clauses are joined with a comma without an accompanying coordinating conjunction. Some prescriptivists exclude comma splices from the definition of a run-on sentence, but this does not imply that they consider comma splices to be acceptable.