Aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder in adults, children, and adolescents. Used as maintenance therapy, it is useful for the prevention of manic episodes, but is not useful for bipolar depression.
The enormous population of 23.5 million (23,500,000) is also due to the fact that Karachi is the main business center of, almost, all the corporations in Pakistan. Having population density of 6,663/km2, it is also a main hub of higher education in Muslim world. See Also; 10 Most Dangerous Cities in The World.
Pakistan has 8 cities with more than a million people, 56 cities with between 100,000 and 1 million people, and 285 cities with between 10,000 and 100,000 people. The largest city in Pakistan is Karachi, with a population of 11,624,219 people. This city is the 7th most populous city in the entire world. 11,624,219.