The toxic effect is related linearly through a relatively large range of body weights, to the body weight of the victim, and, The mechanism of toxicity is the same for âsimilar animalsâ, i. e. one may conduct toxicity tests on say rats or mice and apply the LD50 data to human, since both are mammals.
For moderate menstrual cramps, the nonsteroidal anti-inflammatory drugs (NSAIDs, such as ibuprofen [Advil, Motrin, Nuprin, etc.] or naproxen [Aleve, Anaprox, Naprosyn, Naprelan]) are often helpful.
1 Smooth muscle relaxants, including hyoscyamine (Levsin) and dicyclomine (Bentyl), may help relieve cramping. 2  Tricyclic antidepressants such as amitriptyline (Elavil) imipramine (Tofranil) have been shown to relieve symptoms for people with severe pain and diarrhea.any over-the-counter medications can help relieve symptoms of IBS. These include: 1  Fiber supplements or mild laxatives such as Milk of Magnesia to relieve constipation. 2  Anti-motility medications such as loperamide (Imodium) or Kaopectate to reduce diarrhea.