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Crohn's disease is caused by a combination of environmental, immune and bacterial factors in genetically susceptible individuals. It results in a chronic inflammatory disorder, in which the body's immune system attacks the gastrointestinal tract possibly directed at microbial antigens.
Crohn's disease (sometimes called Crohn disease) is a chronic inflammatory disease of the intestines. It primarily causes ulcerations (breaks in the lining) of the small and large intestines, but can affect the digestive system anywhere from the mouth to the anus. Crohn's disease is a chronic inflammatory disease of the intestines. 2  The cause of Crohn's disease is unknown. 3  Crohn's disease can cause ulcers in the small intestine, colon, or both.