Aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder in adults, children, and adolescents. Used as maintenance therapy, it is useful for the prevention of manic episodes, but is not useful for bipolar depression.
Pakistan's 2nd most populous city, Lahore, is only about half the size, with just 6.3 million people, but is still the world's 15th most populous city. Pakistan has six additional cities that have passed the one million population mark.
Islamabad/Rawalpindi Metropolitan Area is the third largest in Pakistan, with a population of over 4.5 million. The area is drained by two major rivers; Kurang River and Soan River. Three dams; Rawal Lake, Simly Dam, and Khanpur Dam are located in the region, providing water to the local population.slamabad is located in the Pothohar Plateau in the north of the country, within the Islamabad Capital Territory. The region has historically been a part of the crossroads of Punjab and North-West Frontier Province, Margalla pass being a gateway to the North-West Frontier Province.