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Crohn's disease is caused by a combination of environmental, immune and bacterial factors in genetically susceptible individuals. It results in a chronic inflammatory disorder, in which the body's immune system attacks the gastrointestinal tract possibly directed at microbial antigens.
Crohn disease is a chronic inflammatory condition that causes ongoing inflammation of the intestinal tract from the mouth to the rectum. It is similar to ulcerative colitis, another inflammatory bowel disease.But ulcerative colitis is usually confined to the innermost layer of the large intestine and rectum.he most common signs and symptoms of Crohn disease are diarrhea and abdominal pain. Symptoms can range from mild to severe. 1  Diarrhea (with or without blood). 2  Abdominal pain and bloating.