Qualitative and quantitative factor deficiencies can affect the function of the coagulation pathways. Factor V and factor II (prothrombin) mutations are examples of qualitative deficiencies and are the most common inherited predisposing factors for blood clots.
Definition. A comma splice is a run on sentence, where two or more independent clauses are 'spliced' or split by a comma. A comma splice is considered a significant English error.
Grammarians disagree as to whether a comma splice also constitutes a run-on sentence. Some run-on sentence definitions include comma splices, but others limit the term to independent clauses that are joined without punctuation, thereby excluding comma splices.