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There are four key causes of low creatinine: low muscle mass; liver problems; diet; pregnancy or illness; Low muscle mass. Levels of creatinine are often linked with muscle mass or the amount of muscle in the body, which can decrease with age or illness.
A high creatinine level is usually suggestive of serious kidney damage or some renal disease. Increased creatinine clearance can occur due to strenuous exercise, burns, muscle injury, and carbon monoxide poisoning. If BUN to creatinine ratio is high, there is a risk of sudden kidney failure.he kidneys filter the blood and throw creatinine out of the body through urine. If the kidneys fail to do so effectively due to some kidney disease, the creatinine level in the urine decreases and that in the blood increases. This test is usually performed to check whether the kidneys are functioning normally.