The toxic effect is related linearly through a relatively large range of body weights, to the body weight of the victim, and, The mechanism of toxicity is the same for âsimilar animalsâ, i. e. one may conduct toxicity tests on say rats or mice and apply the LD50 data to human, since both are mammals.
For moderate menstrual cramps, the nonsteroidal anti-inflammatory drugs (NSAIDs, such as ibuprofen [Advil, Motrin, Nuprin, etc.] or naproxen [Aleve, Anaprox, Naprosyn, Naprelan]) are often helpful.
OTC pain relief medications that are formulated to treat menstrual cramps, such a Pamprin and Midol, can be an effective treatment for bad leg cramps. You may also be able to prevent or alleviate muscle cramps in your legs by making simple lifestyle changes.