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There are four key causes of low creatinine: low muscle mass; liver problems; diet; pregnancy or illness; Low muscle mass. Levels of creatinine are often linked with muscle mass or the amount of muscle in the body, which can decrease with age or illness.
In addition to kidney diseases and dehydration, other conditions that can cause elevated creatinine levels include heart failure, dehydration, excessive blood loss that causes shock, gout, strenuous exercise, muscle injury, etc.es, the transient increases in creatinine can be caused by dehydration. Dehydration generally causes BUN levels to rise more than creatinine levels. This causes a high BUN-to-creatinine ration.