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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
It is recommended that you take Unisom SleepTabs 30 minutes before going to bed for the evening. Unisom Liquid, SleepGels, SleepMelts, and PM Pain should be taken at bedtime. Taking the product too late at night may cause some morning drowsiness.