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The primary function of all lymph nodes is the production of lymphocytes, which help defend the body against microorganisms and against harmful foreign particles and debris from lymph before it is returned to the blood stream.The major clusters of lymph nodes are in six areas.Those areas are: (1) ...he primary function of all lymph nodes is the production of lymphocytes, which help defend the body against microorganisms and against harmful foreign particles and debris from lymph before it is returned to the blood stream.
1 The thymus gland is the main organ of the lymphatic system. 2  Its primary function is to promote the development of specific cells of the immune system called T-lymphocytes. 3  Once mature, these cells leave the thymus and are transported via blood vessels to the lymph nodes and spleen.he primary functions of the lymphatic system are to drain and return interstitial fluid to the blood, to absorb and return lipids from the digestive system to the blood, and to filter fluid of pathogens, damaged cells, cellular debris, and cancerous cells.