1 In January of 1857 the first performances of The Frozen Deep are given. Dickens plays the role of Richard Wardour. This play gives Dickens the idea for A Tale of Two Cities.  In August of 1857 Dickens meets Ellen Ternan, an actress hired to act in benefit performances of The Frozen Deep.
If you overload your liver (drink too much at one time), the excess alcohol will end up circulating in your bloodstream affecting your brain, heart and other tissues resulting in you becoming increasingly intoxicated.
Risk factors. An explanation of alcohol related liver disease. The risk factors presently known are: Quantity of alcohol taken: Consumption of 60â80g per day (about 75â100 mL/day) for 20 years or more in men, or 20g/day (about 25 mL/day) for women significantly increases the risk of hepatitis and fibrosis by 7% to 47%,