The resulting mRNA is a single-stranded copy of the gene, which next must be translated into a protein molecule. During translation, which is the second major step in gene expression, the mRNA is read according to the genetic code, which relates the DNA sequence to the amino acid sequence in proteins (Figure 2).
This group of drugs followed and largely superseded another group of medications with similar effects, but a different mode of action, called H2-receptor antagonists. PPIs are among the most widely sold drugs in the world, and the first one, omeprazole, is on the WHO Model List of Essential Medicines.
PPIs are among the most widely sold drugs in the world, and the first one, omeprazole, is on the World Health Organization's List of Essential Medicines.igh dose and/or long-term use of PPIs carries a possible increased risk of bone fractures which was not found with short-term, low dose use; the FDA included a warning regarding this on PPI drug labels in 2010.