During the last decade, the efficacy of arsenic trioxide in both newly diagnosed and relapsed patients with APL 3 has been established. Arsenic trioxide can be used as a single agent and induces complete remissions with only minimal myelosuppression (1) (2, 3, 4, 5) . In one study (2) (1) .Additional studies conducted in the United States confirmed that low doses of arsenic trioxide can induce complete remission in relapsed APL patients.hite arsenic or arsenic trioxide (As 2 O 3) is produced by heating realgar (10) . Arsenic is rarely found in a pure state; rather, it exists in both trivalent and pentavalent oxidation states as a chemically unstable sulfide or oxide, or as a salt of sodium, potassium, or calcium (11) .
The most common statin side effects include: 1  Headache. 2  Difficulty sleeping. 3  Flushing of the skin.  Muscle aches, tenderness, or weakness 1  (myalgia) Drowsiness. 2  Dizziness. Nausea or vomiting.  Abdominal cramping 1  or pain. Bloating 2  or gas. 3  Diarrhea. Constipation.  Rash.
And approximately 0.1% of statin users develop Rhabdomyolysis, which is a life threatening condition caused by toxicity due to massive muscle cell death (this starts with the experience of muscle pain, fatigue, and weakness, and progresses).uscle pain side effects of Statin drugs generally get lumped together. Mypopathy, myalgia, ache, pain, fatigue, weakness all get grouped together. Basically, if you take Statins muscle pain is a likely outcome. As I said, experts in the field say 25% of statin users have statin drug side effects.