1 In January of 1857 the first performances of The Frozen Deep are given. Dickens plays the role of Richard Wardour. This play gives Dickens the idea for A Tale of Two Cities.  In August of 1857 Dickens meets Ellen Ternan, an actress hired to act in benefit performances of The Frozen Deep.
If you overload your liver (drink too much at one time), the excess alcohol will end up circulating in your bloodstream affecting your brain, heart and other tissues resulting in you becoming increasingly intoxicated.
Beyond that, the effect of chronic alcohol use on the liver can lead to changes in the way some drugs, including certain antibiotics, are metabolized. If you drink heavily and regularly, be sure to let your physician know that, especially if an antibiotic is prescribed.