1 In January of 1857 the first performances of The Frozen Deep are given. Dickens plays the role of Richard Wardour. This play gives Dickens the idea for A Tale of Two Cities.  In August of 1857 Dickens meets Ellen Ternan, an actress hired to act in benefit performances of The Frozen Deep.
If you overload your liver (drink too much at one time), the excess alcohol will end up circulating in your bloodstream affecting your brain, heart and other tissues resulting in you becoming increasingly intoxicated.
Liver Disease. Liver disease is one of the most common effects of long term alcohol abuse. The liver is the organ that breaks down the alcohol and then excretes the alcohol into bile or blood. When liver disease happens, the user can also develop skin, brain and nervous system problems.