Type 4 Waardenburg syndrome (also called Waardenburg-Shah syndrome) is characterized by symptoms of Hirschsprung's disease in addition to the classic features of hearing loss and pigmentation abnormalities.
[Effects of a vitamin B complex on functional recovery after nerve injury (author's transl)]. Hasegawa K, Mikuni N, Sakai Y. Functional recovery after nerve crushing was investigated in the following manner: Under pentobarbital anesthesia the sciatic nerve of the rat was crushed at the level of the hip (proximal crush) or the thigh (distal crush).
Because of folate's role in fetal spinal cord development, the researchers sought to determine if the vitamin could promote healing in damaged adult nervous system tissue. In a previous study, the researchers showed that folate could enhance the regrowth of axons, or nerve fibers, in rats with spinal cord injuries.