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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
If your doctor recommends against Unisom or other sleep aids during pregnancy, there are still steps you can take to sleep better. Try the following for a better nightâs rest. 1  Exercise 30 minutes per day, with your physicianâs OK.  Sleep on your left side, which improves blood flow to your baby and kidneys.