You only need the English Proficient for international operations as it's an ICAO thing. Some countries, like France, check; others may not. Similar on the RRTO -- some countries, like Canada and the Bahamas don't require it, but others, like Turks & Caicos, do require it and do check it.
Apoptosis, or programmed cell death, is a naturally occurring process in the body. It involves a controlled sequence of steps in which cells signal self termination. Apoptosis works to keep the body's natural cell division process of mitosis in check.
Apoptosis (cell death) occurs at the restriction checkpoint if the cell did not complete mitosis and is abnormal (there are 3 checkpoints, one prior to G1, one prior to mitosis, and one before the end of mitosis). Some specialized cells no longer go through the cell cycle: Muscle cells.