1 In January of 1857 the first performances of The Frozen Deep are given. Dickens plays the role of Richard Wardour. This play gives Dickens the idea for A Tale of Two Cities.  In August of 1857 Dickens meets Ellen Ternan, an actress hired to act in benefit performances of The Frozen Deep.
If you overload your liver (drink too much at one time), the excess alcohol will end up circulating in your bloodstream affecting your brain, heart and other tissues resulting in you becoming increasingly intoxicated.
Long-term addiction to alcohol can take a great toll on a personâs body and brain. Alcohol consumption affects the heart and can cause an irregular heartbeat, stroke, or high blood pressure. However, liver damage is the most prominent side effect, including fatty liver, alcoholic hepatitis, fibrosis, and cirrhosis.