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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
I've been taking Unisom off and on for over a year. I have never had any side effects from taking the drug. I try to take it around 9:30 - 10:00 and fall asleep by 11 - 11:30. I wake up to use the bathroom once a night and can go back to sleep right away. I always wake up around 7.