Splenic-flexure syndrome is a chronic disorder that may be caused by gas trapped at bends (flexures) in the colon. Crohn's disease, colon cancer, or any disease that causes intestinal obstruction, may also cause abdominal bloating. Internal hernias or adhesions (scar tissue) from surgery may cause bloating or pain.
For many years it was thought that the maximum number of folds that could be achieved was just seven! This was the case until when in 2002 American teenager Britney Gallivan demonstrated that a sheet of paper can be folded 12 times, provided that it is long enough and thin enough.
The most frequently used paper size is A4 measuring 210 by 297 millimetres (8.3 in Ã 11.7 in). The significant advantage of this system is its scaling: if a sheet with an aspect ratio of is divided into two equal halves parallel to its shortest sides, then the halves will again have an aspect ratio of. Folded brochures of any size can be made by using sheets of the next larger size, e.g.