The resulting mRNA is a single-stranded copy of the gene, which next must be translated into a protein molecule. During translation, which is the second major step in gene expression, the mRNA is read according to the genetic code, which relates the DNA sequence to the amino acid sequence in proteins (Figure 2).
This group of drugs followed and largely superseded another group of medications with similar effects, but a different mode of action, called H2-receptor antagonists. PPIs are among the most widely sold drugs in the world, and the first one, omeprazole, is on the WHO Model List of Essential Medicines.
Akin Oyalowo CRC Rotation IRB Proposal August 8, 2012 Tapered Withdrawal of a Proton Pump Inhibitor to Prevent Rebound Acid-Related Symptoms A. Study Purpose and Rationale Proton pump inhibitors (PPIs) are among the most commonly used medications in the US, and the use of PPIs continues to increase.ithdrawing PPI therapy after healing esophagitis does not worsen symptoms or cause persistent hypergastrinemia: analysis of dexlansoprazole MR clinical trial data. Am J Gastroenterol 2011 ;106:1953â60. 12. Kulich KR, Madisch A, Pacini F, et al.