ABSTRAL must be kept out of reach of children. [see Patient Counseling Information (17.1) and How Supplied/Storage and Handling (16.1)] The concomitant use of ABSTRAL with CYP3A4 inhibitors may result in an increase in fentanyl plasma concentrations, and may cause potentially fatal respiratory depression.
Renal osteodystrophy. Renal osteodystrophy or chronic kidney disease-mineral and bone disorder is a bone pathology, characterized by bone mineralization deficiency, that is a direct result of the electrolyte and endocrine derangements that accompany chronic kidney disease.
Osteoarthritis (OA) is a condition in which the cartilage between the bones wears down. Cartilage cushions your bones and helps you move your joints smoothly. Without enough cartilage, your bones rub together, causing pain, stiffness, and limited motion.Osteoarthritis of the knee is the most common form of knee arthritis, according to the American Academy of Orthopaedic Surgeons (AAOS) .ithout enough cartilage, your bones rub together, causing pain, stiffness, and limited motion. Osteoarthritis of the knee is the most common form of knee arthritis, according to the American Academy of Orthopaedic Surgeons (AAOS) .