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activation energy. activation energy, in chemistry, minimum energy needed to cause a chemical reaction. A chemical reaction between two substances occurs only when an atom, ion, or molecule of one collides with an atom, ion, or molecule of the other.
Lesson Summary. The activation energy is the energy required to start a reaction. Enzymes are proteins that bind to a molecule (substrate) to modify it and lower the energy required to make it react. The rate of reaction is given by the Arrhenius equation. The rate of reaction increases if the activation energy decreases.