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Weight gain and increase in appetite â Sometimes if you are also taking an immunosuppressive, the appetite might be decreased. Your metabolism is how you burn fat. As you age, your metabolism tends to slow down. Prednisone can have a negative effect on metabolism.oss of muscle mass â Exercise is very important for keeping muscle mass. While on prednisone, try to exercise within your own range. Men have a better chance of building up their muscles after the age of 50 than woman do because of testosterone, but exercise can help woman as well.
NO : The only way to reduce the side effects of prednisone is to take the least amount possible and still be effective in controlling the disease process. If your doctor feels it is possible try to taper with the doctor's guidance. Best wishes. ...Read more.