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Overview of Xylazine for Dogs and Cats. 1  Xylazine, commonly known as Rompun, belongs to a class of drugs known as alpha 2 adrenergic agonists and is similar to clonidine. 2  It is a sedative that provides pain relief as well as muscle relaxation to dogs.
PharmacokineticsIn all studied species (horse, dog, cattle and sheep) the pharmacokinetics of xylazine is best described by a 2-compartment model with a rapid distribution phase. The half-life of distribution is Â½-6 minutes and the half-life of elimination is 23-50 minutes, depending on species.