1 In January of 1857 the first performances of The Frozen Deep are given. Dickens plays the role of Richard Wardour. This play gives Dickens the idea for A Tale of Two Cities.  In August of 1857 Dickens meets Ellen Ternan, an actress hired to act in benefit performances of The Frozen Deep.
If you overload your liver (drink too much at one time), the excess alcohol will end up circulating in your bloodstream affecting your brain, heart and other tissues resulting in you becoming increasingly intoxicated.
Alcohol Effects on the Liver. The liver is an organ that takes the most abuse from alcohol consumption and is probably the most commonly thought of when discussing the harming effects of alcohol on your body. Alcoholic Liver Disease (ALD) is a blanket term in which conditions related specifically to the liver and alcohol use fall under.