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The documented causes of hair-shaft discoloration include certain disease states, medications, and exogenous chemicals. The predominant cause of yellow hair, or xanthotrichia, has been determined to be exogenous chemicals. Some of the compounds implicated in yellow hair discoloration include selenium sulfide 2.5% (anti-dandruff) shampoo and dihydroxyacetone (found in self-tanners).
Another primary source of yellow hair shaft discoloration is the chemical dithranol, which is found in the psoriatic topical medication anthralin, according to the Journal of Drugs in Dermatology research study. The skin cream slows the production of skin cells, according to Drugs.com.