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Weight gain and increase in appetite â Sometimes if you are also taking an immunosuppressive, the appetite might be decreased. Your metabolism is how you burn fat. As you age, your metabolism tends to slow down. Prednisone can have a negative effect on metabolism.oss of muscle mass â Exercise is very important for keeping muscle mass. While on prednisone, try to exercise within your own range. Men have a better chance of building up their muscles after the age of 50 than woman do because of testosterone, but exercise can help woman as well.
The fat effect: Prednisone, often used to treat rheumatoid arthritis and chronic inflammation, can make you feel ravenously hungry. What to do: Your doctor may be able to give you prescription-strength NSAIDs (nonsteroidal anti-inflammatory drugs, such as ibuprofen) to help.hat to do: See a psychiatrist instead of a family physician or internist and ask about antidepressants that dont typically cause weight gain, such as Wellbutrin or Zyban. Birth control pills. The fat effect: Birth control pills may add up to five pounds because the estrogen in them can cause you to retain water.