Rosa Parks was born Rosa Louise McCauley in Tuskegee, Alabama, on February 4, 1913, to Leona (nÃ©e Edwards), a teacher, and James McCauley, a carpenter. She was of African ancestry, though one of her great-grandfathers was Scots-Irish and one of her great-grandmothers was a slave of Native American descent.
Fentanyl (also known as fentanil) is a potent, synthetic opioid pain medication with a rapid onset and short duration of action. It is a potent agonist at Î¼-opioid receptors in the brain. Fentanyl is 50 to 100 times more potent than morphine, but some fentanyl analogues, which are designed to mimic the pharmacological effects of the original drug, may be as much as 10,000 times more potent than morphine.
Chemistry and Pharmacology: Fentanyl is about 100 times more potent than morphine as an analgesic. It is a Âµ-opioid receptor agonist with high lipid solubility and a rapid onset and short duration of effects. Fentanyl rapidly crosses the blood-brain barrier. It is similar to other -Âµopioid receptor agonists (like morphine or oxycodone) in its pharmacological effects and produces analgesia, sedation, respiratory depression, nausea, and vomiting. Fentanyl appears to produce muscle rigidity with greater frequency than other opioids.