Type 4 Waardenburg syndrome (also called Waardenburg-Shah syndrome) is characterized by symptoms of Hirschsprung's disease in addition to the classic features of hearing loss and pigmentation abnormalities.
[Effects of a vitamin B complex on functional recovery after nerve injury (author's transl)]. Hasegawa K, Mikuni N, Sakai Y. Functional recovery after nerve crushing was investigated in the following manner: Under pentobarbital anesthesia the sciatic nerve of the rat was crushed at the level of the hip (proximal crush) or the thigh (distal crush).
Several studies on animals have demonstrated that Vitamin B12 can extenuate nerve damage caused by neuropathy by activating a chemical signal, which helps nerves to regenerate. (6) Clinical trials have also demonstrated how significant ViaminsB12 and B6 are in the treatment of neuropathic symptoms.