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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
Unisom is used for: Treating occasional sleeplessness and reducing difficulty falling asleep. Unisom is an antihistamine. It works by depressing the central nervous system (brain) to produce drowsiness. Do NOT use Unisom if: you are allergic to any ingredient in Unisom or other similar medicines. you are taking sodium oxybate (GHB) or you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) in the past 2 weeks.