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The primary function of all lymph nodes is the production of lymphocytes, which help defend the body against microorganisms and against harmful foreign particles and debris from lymph before it is returned to the blood stream.The major clusters of lymph nodes are in six areas.Those areas are: (1) ...he primary function of all lymph nodes is the production of lymphocytes, which help defend the body against microorganisms and against harmful foreign particles and debris from lymph before it is returned to the blood stream.
Lymph Node Function. Lymph nodes serve two major functions in the body. They filter lymph and assist the immune system in building an immune response. Lymph is a clear fluid that comes from blood plasma that exits blood vessels at capillary beds.This fluid becomes the interstitial fluid that surrounds cells.ymphoma is the term used for cancer that begins in the lymphatic system. This type of cancer originates in the lymphocytes that inhabit lymph nodes and lymph tissues. Lymphomas are grouped into two main types: Hodgkin's lymphoma and Non-Hodgkin lymphoma (NHL) .