During the last decade, the efficacy of arsenic trioxide in both newly diagnosed and relapsed patients with APL 3 has been established. Arsenic trioxide can be used as a single agent and induces complete remissions with only minimal myelosuppression (1) (2, 3, 4, 5) . In one study (2) (1) .Additional studies conducted in the United States confirmed that low doses of arsenic trioxide can induce complete remission in relapsed APL patients.hite arsenic or arsenic trioxide (As 2 O 3) is produced by heating realgar (10) . Arsenic is rarely found in a pure state; rather, it exists in both trivalent and pentavalent oxidation states as a chemically unstable sulfide or oxide, or as a salt of sodium, potassium, or calcium (11) .
The most common statin side effects include: 1  Headache. 2  Difficulty sleeping. 3  Flushing of the skin.  Muscle aches, tenderness, or weakness 1  (myalgia) Drowsiness. 2  Dizziness. Nausea or vomiting.  Abdominal cramping 1  or pain. Bloating 2  or gas. 3  Diarrhea. Constipation.  Rash.
Side effects of statins. Many people who take statins experience no or very few side effects. Others experience some troublesome â but usually minor â side effects, such as an upset stomach, headache or feeling sick. Your doctor should discuss the risks and benefits of taking statins if they're offered to you.tatins can sometimes interact with other medicines, increasing the risk of unpleasant side effects, such as muscle damage. Some types of statin can also interact with grapefruit juice.