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GABA is made in brain cells from glutamate and works by blocking nerve impulses. Glutamate fires the nerve impulses and GABA does the opposite by telling the nerves not to fire. In the case of GABA deficiency, nerve cells fire too often and too easily.hat is where GABA comes in. Gamma-Amino Butyric acid (GABA) is an amino acid which acts as a neurotransmitter in the central nervous system.
Gabaergic neurons which produce GABA. Exogenous GABA does not penetrate the bloodâbrain barrier; it is synthesized in the brain. It is synthesized from glutamate using the enzyme L-glutamic acid decarboxylase (GAD) and pyridoxal phosphate (which is the active form of vitamin B6) as a cofactor.eurons that produce GABA as their output are called GABAergic neurons, and have chiefly inhibitory action at receptors in the adult vertebrate. Medium Spiny Cells are a typical example of inhibitory CNS GABAergic cells.