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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
A urinary tract infection (UTI) will make you have to pee at night. It may hurt when you pee, your stomach may ache, and you might have a fever. Your doctor can diagnose and treat a UTI. The older you are, the more likely you are to need to pee more at night. As you age, your body makes less of the hormone that tells your kidneys to work less while you sleep. Also, your bladder isnât as stretchy, so you canât hold as much as you used to. When you're older you're also more likely to have other health problems that make you need to pee overnight. Your gender can play a role, too: Men: An enlarged prostate is common when you're an older guy.