1 In January of 1857 the first performances of The Frozen Deep are given. Dickens plays the role of Richard Wardour. This play gives Dickens the idea for A Tale of Two Cities.  In August of 1857 Dickens meets Ellen Ternan, an actress hired to act in benefit performances of The Frozen Deep.
If you overload your liver (drink too much at one time), the excess alcohol will end up circulating in your bloodstream affecting your brain, heart and other tissues resulting in you becoming increasingly intoxicated.
Alcohol travels through the intestines to the liver and then on to the heart, brain, muscles and other tissues. This happens very quickly-within a few minutes. Usually, though not always, this has a pleasant effect. Your body canât store alcohol, so it breaks it down-your liver's job. The liver firstly changes alcohol into acetaldehyde (this is toxic), then into acetate (harmless), which is finally broken down into carbon dioxide and water. Find out more about how alcohol can effect you from our interactive male and female bodies. About 90-95% of alcohol consumed is broken down by the liver, 5-10% is excreted through urine, breath and sweat.Your bodyâs ability to process alcohol depends on your age, weight and sex.