Definition. Phenylketonuria (PKU) can be defined as a rare metabolic disorder caused by a deficiency in the production of the hepatic (liver) enzyme phenylalanine hydroxylase (PAH).bbr. PKU A genetic disorder in which the body lacks the enzyme necessary to metabolize phenylalanine to tyrosine. Left untreated, the disorder can cause brain damage and progressive mental retardation as a result of the accumulation of phenylalanine and its breakdown products.
OAHU FUN FACTS. 1) Oahu is 44 miles long, 30 miles wide, 112 miles around and is the third-largest island in the Hawaiian chain of 132 islets, atolls and reefs stretching from kure atoll in the northwest to the big island of Hawaii in the southeast. 2) Honolulu is the largest city in the world.
The Pacific Ocean surrounds the Hawaiian archipelago. There are eight major and 124 minor islands, volcanic in origin, with a total land mass of 6,425 square miles (16,641 square kilometers). The eight major islands are Niihau, Kauai, Oahu, Molokai, Maui, Kahoolawe, Lanai, and Hawaii. Honolulu, the capital, is located on Oahu, and is 6,200 kilometers southwest of San Francisco. The islands' topography includes such diverse features as active volcanos, grassy pastures, and endless stretches of beach.