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These 10 facts about space will blow your mind. Blood blisters are a type of blister filled with blood rather than the clear fluid commonly associated with blisters. They are caused by a rupture of the blood vessels underneath the skinâs surface, usually cause by some form of trauma, such as pinching.
Blood blisters under big toes (image credit) The presence of blood in a blister indicates there is high pressure component. This high pressure causes deeper injury - injury to small blood vessels in the dermis. Blood then tracks into the epidermis and mixes with the normal blister fluid. That's why blood blisters often occur over joints and bony prominences: like the back of the heel, the toes and the metatarsal heads (ball of the foot). Blood vessels exist in the dermis - not the epidermis where blisters form.