ABSTRAL must be kept out of reach of children. [see Patient Counseling Information (17.1) and How Supplied/Storage and Handling (16.1)] The concomitant use of ABSTRAL with CYP3A4 inhibitors may result in an increase in fentanyl plasma concentrations, and may cause potentially fatal respiratory depression.
Renal osteodystrophy. Renal osteodystrophy or chronic kidney disease-mineral and bone disorder is a bone pathology, characterized by bone mineralization deficiency, that is a direct result of the electrolyte and endocrine derangements that accompany chronic kidney disease.
By Dr Tomislav MeÅ¡troviÄ, MD, PhD. Osteoarthritis (OA) is the most common form of joint disease. This chronic, degenerative disorder results from the biochemical breakdown of cartilage in the synovial joints. Its symptoms tend to develop gradually and include joint aches, stiffness and swelling. Some joints, like the ankles, may be spared due to a unique resistance of their articular cartilage to loading stress.