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Most often, colon cancer spreads to the liver, but it can also spread to the ovaries, lungs, or brain. Colon cancer tends to spread to the liver first, because all of the blood from the colon drains to the liver before proceeding to the rest of the body.
Patients have a worse prognosis if the cancer has spread to the lymph nodes or distant organs, has invaded blood and lymphatic vessels, or is poorly differentiated. Colorectal cancer is called a metastatic disease when the cancer has spread from the colon or the rectum to another part of the body. Colorectal cancer most commonly spreads to the liver or the lungs.