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Most often, colon cancer spreads to the liver, but it can also spread to the ovaries, lungs, or brain. Colon cancer tends to spread to the liver first, because all of the blood from the colon drains to the liver before proceeding to the rest of the body.
Colon cancer is divided into 5 stages, from stage 0 to stage 4. Stage 4 colon cancer (earlier known as Dukeâs D colon cancer) is the last stage of this cancer. At this stage of the cancer, the cancer is said to have spread to other parts of the body, specifically the lungs, liver, and lymph nodes. Abdominal discomfort: Pain, cramping, bloating, nausea and gas may be felt by those with colon cancer. 2  Jaundice: Since the colon cancer has normally spread to the liver by stage 4, jaundice is also a symptom. 3  Other symptoms include unexplained fever, weight loss, fatigue, thrombosis.