State in writing that the LETTER OF REPRIMAND is being made a part of the employeeâs personnel file. Specify that future disciplinary action will be taken unless there is improvement and specify the measurements for satisfactory performance. Please note that in effect this is a warning as well as a reprimand.
There are thousands of single-gene diseases including achondroplasia, cystic fibrosis, hemophilia, Huntington disease, muscular dystrophy, and sickle cell disease.Single-gene diseases usually follow simple Mendelian patterns of inheritance -- autosomal dominant, an autosomal recessive, or an X-linked.Single gene diseases are as opposed to polygenic diseases which are caused by a combination of two or more genes.ingle-gene diseases usually follow simple Mendelian patterns of inheritance -- autosomal dominant, an autosomal recessive, or an X-linked. Single gene diseases are as opposed to polygenic diseases which are caused by a combination of two or more genes.
A single-gene disorder is the result of a single mutated gene. Over 4000 human diseases are caused by single-gene defects. Single-gene disorders can be passed on to subsequent generations in several ways. Genomic imprinting and uniparental disomy, however, may affect inheritance patterns.ost genetic disorders are quite rare and affect one person in every several thousands or millions. Genetic disorders may or may not be heritable, i.e., passed down from the parents' genes. In non-heritable genetic disorders, defects may be caused by new mutations or changes to the DNA.