1 In January of 1857 the first performances of The Frozen Deep are given. Dickens plays the role of Richard Wardour. This play gives Dickens the idea for A Tale of Two Cities.  In August of 1857 Dickens meets Ellen Ternan, an actress hired to act in benefit performances of The Frozen Deep.
If you overload your liver (drink too much at one time), the excess alcohol will end up circulating in your bloodstream affecting your brain, heart and other tissues resulting in you becoming increasingly intoxicated.
A very serious and common effect of everyday alcohol consumption is cirrhosis of the liver, which can be fatal. The liver of a heavy everyday drinker takes a lot of abuse filtering the alcohol that passes through it. Eventually, the liver begins to filter poorly, as scarring and damage build up over the years.