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Most often, colon cancer spreads to the liver, but it can also spread to the ovaries, lungs, or brain. Colon cancer tends to spread to the liver first, because all of the blood from the colon drains to the liver before proceeding to the rest of the body.
Colon Cancer vs. Colorectal Cancer. Colon cancer is a malignancy that begins in the colon or large intestine. The large intestine is a long tube-like organ near the end of the digestive system. After food passes through the stomach and small intestine, the colon is responsible for removing fluid and some nutrients from the food you eat.