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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
Ingredients in Unisom SleepGels. 50 mg Diphenhydramine HCI: This is the number one recommended sleep aid ingredient recommended by pharmacists. The other inactive ingredients are; blue 1, glycerine, gelatin, titanium dioxide, sorbitol, propylene glycol, polyvinyl acetate phthalate, polythylene glycol and water.