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Fibrous Pericardium. Continuous with the central tendon of the diaphragm, the fibrous pericardium is made of tough connective tissue and is relatively non-distensible. This rigidity prevents rapid overfilling of the heart, but can have several serious clinical consequences (see cardiac tamponade).
The endocarium is the innermost, thin and smooth layer of epithelial tissue that lines the inner surface of all the heart chambers and valves. This layer is made of thin and flat cells that are in direct contact with the blood that flows in and out of the heart. The myocardium is the muscle that makes up the heart. The cardiac muscle structure consists of basic units of cardiac muscle cells known as myocytes. This is the thickest of all the layers of the heart. Pericardium.