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Major causes of sudden cardiopulmonary death include pulmonary embolism, aortic dissection and ruptured aortic aneurysm. Differential diagnosis Other causes of sudden death in young people include: 1  Serious infection - eg, meningitis, encephalitis. 2  Epilepsy. 3  Asthma. 4  Pulmonary embolism. 5  Intracranial haemorrhage.
Some specific causes of sudden cardiac death in young people include: Hypertrophic cardiomyopathy (HCM). This is a disease in which the heart muscle (myocardium) becomes abnormally thick, making it harder for the heart to pump blood. Hypertrophic cardiomyopathy, while usually not fatal in most people, is the most common cause of heart-related sudden death in people under 30. It's the most common cause of sudden death in athletes. HCM often goes undetected.