During the last decade, the efficacy of arsenic trioxide in both newly diagnosed and relapsed patients with APL 3 has been established. Arsenic trioxide can be used as a single agent and induces complete remissions with only minimal myelosuppression (1) (2, 3, 4, 5) . In one study (2) (1) .Additional studies conducted in the United States confirmed that low doses of arsenic trioxide can induce complete remission in relapsed APL patients.hite arsenic or arsenic trioxide (As 2 O 3) is produced by heating realgar (10) . Arsenic is rarely found in a pure state; rather, it exists in both trivalent and pentavalent oxidation states as a chemically unstable sulfide or oxide, or as a salt of sodium, potassium, or calcium (11) .
The most common statin side effects include: 1  Headache. 2  Difficulty sleeping. 3  Flushing of the skin.  Muscle aches, tenderness, or weakness 1  (myalgia) Drowsiness. 2  Dizziness. Nausea or vomiting.  Abdominal cramping 1  or pain. Bloating 2  or gas. 3  Diarrhea. Constipation.  Rash.
A recent study of more than 100,000 people who'd been prescribed statins from 2000 to 2008 found that 17 percent of patients reported side effects such as muscle pain, nausea, and liver and nervous system problems.