1 In January of 1857 the first performances of The Frozen Deep are given. Dickens plays the role of Richard Wardour. This play gives Dickens the idea for A Tale of Two Cities.  In August of 1857 Dickens meets Ellen Ternan, an actress hired to act in benefit performances of The Frozen Deep.
If you overload your liver (drink too much at one time), the excess alcohol will end up circulating in your bloodstream affecting your brain, heart and other tissues resulting in you becoming increasingly intoxicated.
Many psychological effects of alcohol on the brain can also be seen in a form of a type of liver damage known as hepatic encephalopathy. Hepatic encephalopathy is a worsening of brain function that occurs when the liver is no longer able to remove toxic substances in the blood. The psychological effects of alcohol from hepatic encephalopathy include: xiii. 1  Sleep pattern changes. 2  Changes in mood and personality. 3  Depression, anxiety and other psychiatric conditions.