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Report Abuse. When I have taken Vicodin...It would take about 20 minutes for it to kick-in....I know that depending on what dose you are taking and how bad your pain is can also effect how long it takes to kick-in... Chi Town Jaki Â· 8 years ago. Thumbs up.
Best Answer: Usually, it depends on what you took. Pills like vicodin, delsyum, and oxycodin usually you'll be able to tell in 10-15 min. It can also happen slowly though, as long term effects kick in, such as liver damage. Source(s): personal experince.