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DRUG DESCRIPTION. ZanaflexÂ® (tizanidine hydrochloride) is a central alpha2-adrenergic agonist. Tizanidine HCl is a white to off-white, fine crystalline powder, which is odorless or with a faint characteristic odor. Tizanidine is slightly soluble in water and methanol; solubility in water decreases as the pH increases.
DRUG CLASS AND MECHANISM: Tizanidine is a skeletal muscle relaxant. It works on alpha2 receptors in the central nervous system (brain and spinal cord) and blocks nerve impulses from reaching muscles which produces muscle relaxation.The FDA approved tizanidine in November 1996.RESCRIBED FOR: Tizanidine is used for the treatment and management of skeletal muscle spasticity. Spasticity may be due to multiple sclerosis or spinal cord injury. DOSING: Initially take 2 - 4 mg by mouth every 6 to 8 hours for up to 3 doses in 24 hours.