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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
So put away the hemorrhoid cream. If your under-eye puffiness seems to be caused by a sinus infection, which has resulted in fluid retention, it can help to alter your sleep position until that infection has passed. Try using an extra pillow to prevent the fluid from concentrating below your eyes.