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The primary function of all lymph nodes is the production of lymphocytes, which help defend the body against microorganisms and against harmful foreign particles and debris from lymph before it is returned to the blood stream.The major clusters of lymph nodes are in six areas.Those areas are: (1) ...he primary function of all lymph nodes is the production of lymphocytes, which help defend the body against microorganisms and against harmful foreign particles and debris from lymph before it is returned to the blood stream.
The lymphatic system plays a vital role in the proper functioning of the body. One of the major roles of this organ system is to drain excess fluid surrounding tissues and organs and return it to the blood. Returning lymph to the blood helps to maintain normal blood volume and pressure.It also prevents edema, the excess accumulation of fluid around tissues. The spleen is the largest organ of the lymphatic system. 2  Its primary function is to filter blood of damaged cells, cellular debris, and pathogens. 3  Like the thymus, the spleen houses and aids in the maturation of lymphocytes. 4  Lymphocytes destroy pathogens and dead cells in the blood.