1 In January of 1857 the first performances of The Frozen Deep are given. Dickens plays the role of Richard Wardour. This play gives Dickens the idea for A Tale of Two Cities.  In August of 1857 Dickens meets Ellen Ternan, an actress hired to act in benefit performances of The Frozen Deep.
If you overload your liver (drink too much at one time), the excess alcohol will end up circulating in your bloodstream affecting your brain, heart and other tissues resulting in you becoming increasingly intoxicated.
How alcohol affects functioning of different organs. The most well known alcohol abuse effect is on the liver. Consumption of alcohol at the young age causes damages to the cirrhosis of the liver. The cleaning of the toxins out of our body is done by the cirrhosis of the liver and this stops the functioning on alcohol abuse.