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Whatâs more, aside from increased level of ammonia in the blood, other symptoms also can be induced such as muscle weakness, fatigue, lethargy and so on. In addition, if left untreated, elevated blood ammonia can affect brain tissue, leading to symptoms such as confusion and delirium.
Urea is removed from the blood by the kidneys and excreted in the urine. In urea cycle disorders, nitrogen levels builds up in the blood as ammonia, which is a toxic substance. The medical term for this build-up of ammonia is hyperammonemia (elevated blood ammonia). Ammonia reaches the brain through circulation of the blood, where it can cause irreversible brain damage, coma and/or death.