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activation energy. activation energy, in chemistry, minimum energy needed to cause a chemical reaction. A chemical reaction between two substances occurs only when an atom, ion, or molecule of one collides with an atom, ion, or molecule of the other.
We can also study enzymes in the context of activation energy. Many biochemical reactions need a little input of energy to jump-start a thermodynamically favorable reaction. The activation energy is the amount of energy needed for the reaction to go forward and get over its activation barrier. ATP (adenosine triphosphate), the cellâs energy carrier, needs a little help to get over its activation barrier.