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Report Abuse. When I have taken Vicodin...It would take about 20 minutes for it to kick-in....I know that depending on what dose you are taking and how bad your pain is can also effect how long it takes to kick-in... Chi Town Jaki Â· 8 years ago. Thumbs up.
RE: HOW long does vicodin/hydrocodone take to take effect? So I just got my wisdom teeth extracted and and mygrandparents didn&#39;t think to give me the pills right away like the doctor said so i went and took them when i started to feel pain, any idea as to how long it takes for this drugs effects to kick in?t takes longer if they have worn off to take effect. Usually about 30 mins or longer if the pain is severe. But once it kicks in be sure not to miss the next dose.