Definition. Phenylketonuria (PKU) can be defined as a rare metabolic disorder caused by a deficiency in the production of the hepatic (liver) enzyme phenylalanine hydroxylase (PAH).bbr. PKU A genetic disorder in which the body lacks the enzyme necessary to metabolize phenylalanine to tyrosine. Left untreated, the disorder can cause brain damage and progressive mental retardation as a result of the accumulation of phenylalanine and its breakdown products.
OAHU FUN FACTS. 1) Oahu is 44 miles long, 30 miles wide, 112 miles around and is the third-largest island in the Hawaiian chain of 132 islets, atolls and reefs stretching from kure atoll in the northwest to the big island of Hawaii in the southeast. 2) Honolulu is the largest city in the world.
In total, the islands make up 10,931 square miles of land (28,311 square kilometres) but when it comes to population density, it is ranked number 13 in the US with 214 people per square mile, (82.6 per square kilometre). There are eight major islands in Hawaii. Oahu is the largest, with a population of 953,207. Next largest is Hawaii itself, holding 185,079 people, followed closely by Maui (144,444). The only other island with a sizeable population is Kauai (pop 66,921).