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Deposition of calcium salts in the skin, subcutaneous tissue, or other part of the body in certain pathologic conditions. calcification, the deposit of calcium salts in tissues and organs that do not normally contain them in undissolved form.nterstitial calcinosis (calcium gout) is distinguished by the fact that there is no depletion of calcium in the bones and no excess concentration of calcium in the blood. The depositing of lime occurs in the skin and subcutaneous tissues or may spread to the muscles and other tissues.
Pathophysiology. Giant cell arteritis (GCA) is primarily a disease of cell-mediated immunity, which is thought to arise as a maladaptive response to endothelial injury. Actinic damage to the temporal artery from chronic sun exposure has been proposed as one source of the injury.tiology. The exact etiology of giant cell arteritis (GCA) remains unknown. Despite increased understanding of the inflammatory cascade responsible for the disease process, the initial event that triggers the cascade remains uncertain. Genetic, environmental, and autoimmune factors have been identified.