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Weight gain and increase in appetite â Sometimes if you are also taking an immunosuppressive, the appetite might be decreased. Your metabolism is how you burn fat. As you age, your metabolism tends to slow down. Prednisone can have a negative effect on metabolism.oss of muscle mass â Exercise is very important for keeping muscle mass. While on prednisone, try to exercise within your own range. Men have a better chance of building up their muscles after the age of 50 than woman do because of testosterone, but exercise can help woman as well.
While you are taking prednisone you will need to change what you eat and drink. Prednisone has some side effects, including: 1  weight gain. 2  increased appetite. 3  high blood pressure. 4  higher risk of developing osteoporosisâ or steroid-induced diabetes.odium helps to control the amount of water in our bodies as well as our blood pressure. You need to eat foods that are low in sodium because prednisone can cause you to hold extra water in your body. This causes swelling or puffiness, usually around your eyes and ankles.