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activation energy. activation energy, in chemistry, minimum energy needed to cause a chemical reaction. A chemical reaction between two substances occurs only when an atom, ion, or molecule of one collides with an atom, ion, or molecule of the other.
activation energy. noun, Chemistry. 1. the least amount of energy required to activate atoms or molecules to a state in which they can undergo a chemical reaction. activation energy. (Äk'tÉ-vÄ'shÉn) The least amount of energy needed for a chemical reaction to take place. Some elements and compounds react together naturally just by being close to each other, and their activation energy is zero. Others will react together only after a certain amount of energy is added to them.