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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
Older ones such as chlorpheniramine and diphenhydramine might help a little but can cause drowsiness, dry eyes and mouth, and urinary retention, and can worsen narrow-angle glaucoma. Newer antihistamines, such as loratadine (Alavert, Claritin, and generic), work well for allergies but usually donât help sinus symptoms.