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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
Rare side effects of Unisom Sleepgels: 1  Blood Disorder Severe. 2  Extra Heartbeat Severe. 3  Hallucination Severe. 4  Reaction due to an Allergy Severe. 5  Seizures Severe. 6  Blurred Vision Less Severe. 7  Confused Less Severe. 8  Difficult or Painful Urination Less Severe. 9  Dizzy Less Severe.