ABSTRAL must be kept out of reach of children. [see Patient Counseling Information (17.1) and How Supplied/Storage and Handling (16.1)] The concomitant use of ABSTRAL with CYP3A4 inhibitors may result in an increase in fentanyl plasma concentrations, and may cause potentially fatal respiratory depression.
Renal osteodystrophy. Renal osteodystrophy or chronic kidney disease-mineral and bone disorder is a bone pathology, characterized by bone mineralization deficiency, that is a direct result of the electrolyte and endocrine derangements that accompany chronic kidney disease.
Osteoarthritis is a progressive form of arthritis characterized by breakdown of the cartilage in joints. Osteoarthritis (OA), also known as degenerative joint disease and wear and tear arthritis, causes pain in the joints with activity. The knees and the hips are common locations for osteoarthritis. Osteoarthritis is common in people over 60 years of age, but it can affect younger people, particularly where they have had joint injury or joint surgery.