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Most often, colon cancer spreads to the liver, but it can also spread to the ovaries, lungs, or brain. Colon cancer tends to spread to the liver first, because all of the blood from the colon drains to the liver before proceeding to the rest of the body.
How cancer grows and spreads. Cancer is the growth of abnormal cells in the body. These extra cells grow together and form masses, called tumors. In colorectal cancer, these growths usually start as polyps in the large intestine (colon or rectum). If colon polyps aren't found and removed, they may turn into cancer. Cancers in the colon or rectum usually grow very slowly. It takes most of them years to become large enough to cause symptoms. If the cancer is allowed to grow, over time it will invade and destroy nearby tissues and then spread farther. Colorectal cancer spreads first to nearby lymph nodes.