Splenic-flexure syndrome is a chronic disorder that may be caused by gas trapped at bends (flexures) in the colon. Crohn's disease, colon cancer, or any disease that causes intestinal obstruction, may also cause abdominal bloating. Internal hernias or adhesions (scar tissue) from surgery may cause bloating or pain.
For many years it was thought that the maximum number of folds that could be achieved was just seven! This was the case until when in 2002 American teenager Britney Gallivan demonstrated that a sheet of paper can be folded 12 times, provided that it is long enough and thin enough.
The difference in the number of the page sizes equals the number of times you should fold it. So if you have a C4 or B4 envelope and a sheet of A2 paper, you should fold it in half twice. The same method works for filing larger paper sizes in file folders of a smaller size. This works with the B and C envelope formats.