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Nortriptyline is an active metabolite of Amitriptyline. Therapeutic drug levels are monitored to assist the physician assessing therapeutic response and to avoid toxicity.ortriptyline is an active metabolite of Amitriptyline. Therapeutic drug levels are monitored to assist the physician assessing therapeutic response and to avoid toxicity.
Valium (diazepam) has a long half-life of 30-60 hours in addition diazepam has a number of active metabolites, all of which are benzodiazepines like diazepam. The primary active metabolite is nordazepam (aka desmethyldiazepam), best known under the brand name Calmday (not available in North America) which has a half-life of 30-100 hours.