Weight loss is most often associated with dieting. However, weight loss after chemotherapy is associated with side effects of chemo that can sometimes interfere with your ability to eat or drink and affect your ability to maintain your healthy weight.Chemotherapy weight loss may occur as a result of:1  Poor appetite. 2  Eating less. 3  Diarrhea. 4  Vomiting. 5  Nausea. 6  Dehydration.owever, weight loss after chemotherapy is associated with side effects of chemo that can sometimes interfere with your ability to eat or drink and affect your ability to maintain your healthy weight. Chemotherapy weight loss may occur as a result of: 1  Poor appetite. 2  Eating less. 3  Diarrhea. 4  Vomiting. 5  Nausea. 6  Dehydration.
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