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Nortriptyline is an active metabolite of Amitriptyline. Therapeutic drug levels are monitored to assist the physician assessing therapeutic response and to avoid toxicity.ortriptyline is an active metabolite of Amitriptyline. Therapeutic drug levels are monitored to assist the physician assessing therapeutic response and to avoid toxicity.
Pharmacology. Amitriptyline (Elavil) is an antidepressant with sedative effects. Its mechanism of action in man is not known. It is not a monoamine oxidase inhibitor and it does not act primarily by stimulation of the central nervous system.mitriptyline, because of its sedative action, is also of value in alleviating the anxiety component of depression. As with other tricyclic antidepressants, amitriptyline (Elavil, Endep) may precipitate hypomanic episodes in patients with bipolar depression.