State in writing that the LETTER OF REPRIMAND is being made a part of the employeeâs personnel file. Specify that future disciplinary action will be taken unless there is improvement and specify the measurements for satisfactory performance. Please note that in effect this is a warning as well as a reprimand.
There are thousands of single-gene diseases including achondroplasia, cystic fibrosis, hemophilia, Huntington disease, muscular dystrophy, and sickle cell disease.Single-gene diseases usually follow simple Mendelian patterns of inheritance -- autosomal dominant, an autosomal recessive, or an X-linked.Single gene diseases are as opposed to polygenic diseases which are caused by a combination of two or more genes.ingle-gene diseases usually follow simple Mendelian patterns of inheritance -- autosomal dominant, an autosomal recessive, or an X-linked. Single gene diseases are as opposed to polygenic diseases which are caused by a combination of two or more genes.
Single gene inheritance. Single gene inheritance, also called Mendelian or monogenetic inheritance. This type of inheritance is caused by changes or mutations that occur in the DNA sequence of a single gene. There are more than 6,000 known single-gene disorders, which occur in about 1 out of every 200 births.ome examples of monogenetic disorders include: 1  cystic fibrosis, 2  sickle cell anemia, 3  Marfan syndrome, 4  Huntington's disease, and. 5  hemochromatosis.