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Medical Definition of anaplasma. 1  1 capitalized : a genus of parasitic, gram-negative, nonmotile bacteria of the family Anaplasmataceae that are transmitted chiefly by ticks and biting flies and infect the red blood cells of humans and animalsâsee anaplasmosis. 2  2plural anaplasmas or anaplasmata \-mÉt-É\play : any bacterium of the genus Anaplasma.
Anaplasmosis or human granulocytic anaplasmosis (HGA) is a tick-borne disease caused by the gram-negative, obligate intracellular bacterium Anaplasma phagocytophilum.This means it can only reproduce inside living cells.aboratory Detection: It is important to note, since infection with anaplasmosis in humans may be rapidly progressive and in some instances fatal, antibiotic treatment should never be delayed pending laboratory test results, or be withheld on the basis of an initial negative finding for Anaplasma phagocytophilum.