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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
Most people start with nonprescription sleep aids, such as Sominex or Unisom. These contain a âfirst generationâ antihistamine (diphenhydramine or doxylamine), which causes drowsiness. Though relatively safe, they can impair driving performance the next day.