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Report Abuse. When I have taken Vicodin...It would take about 20 minutes for it to kick-in....I know that depending on what dose you are taking and how bad your pain is can also effect how long it takes to kick-in... Chi Town Jaki Â· 8 years ago. Thumbs up.
On average, most doctors agree that the half life of Vicodin is 4 hours. Vicodin (a combination of hydrocodone and paracetamol) is a short acting opioid analgesic, which means that you can feel the effects of Vicodin quickly (within 30 minutes to 1 hour of taking it) but do not last very long.rug testing for Vicodin. Vicodin can be detected in the urine 2-4 days after you take it. If you are planning to take a drug test for Vicodin, you would be advised to be more conservative and wait the full 4 days before drug testing.