1 In January of 1857 the first performances of The Frozen Deep are given. Dickens plays the role of Richard Wardour. This play gives Dickens the idea for A Tale of Two Cities.  In August of 1857 Dickens meets Ellen Ternan, an actress hired to act in benefit performances of The Frozen Deep.
If you overload your liver (drink too much at one time), the excess alcohol will end up circulating in your bloodstream affecting your brain, heart and other tissues resulting in you becoming increasingly intoxicated.
The bulk of alcohol's metabolism takes place in the liver, which is why the liver is particularly at risk of damage. Alcoholic liver disease is mostly influenced by the amount and duration of alcohol abuse, and chronic heavy drinking poses a substantial risk for its development. At least 90% of people who drink heavily will develop alcoholic fatty liver, an early and reversible consequence of excessive alcohol intake.