ABSTRAL must be kept out of reach of children. [see Patient Counseling Information (17.1) and How Supplied/Storage and Handling (16.1)] The concomitant use of ABSTRAL with CYP3A4 inhibitors may result in an increase in fentanyl plasma concentrations, and may cause potentially fatal respiratory depression.
Renal osteodystrophy. Renal osteodystrophy or chronic kidney disease-mineral and bone disorder is a bone pathology, characterized by bone mineralization deficiency, that is a direct result of the electrolyte and endocrine derangements that accompany chronic kidney disease.
Osteoarthritis is a common degenerative disorder of the articular cartilage associated with hypertrophic changes in the bone.1 Risk factors include genetics, female sex, past trauma, advancing age, and obesity.2 As the U.S. population ages and becomes more obese, family physicians can expect to see more patients with osteoarthritis.