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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
The diphenhydramine HCL formula can be found in the following Unisom products: SleepGels â This easy-to-swallow sleep aid provides the same relaxing effects as other Unisom products but without the chalky taste.