The resulting mRNA is a single-stranded copy of the gene, which next must be translated into a protein molecule. During translation, which is the second major step in gene expression, the mRNA is read according to the genetic code, which relates the DNA sequence to the amino acid sequence in proteins (Figure 2).
This group of drugs followed and largely superseded another group of medications with similar effects, but a different mode of action, called H2-receptor antagonists. PPIs are among the most widely sold drugs in the world, and the first one, omeprazole, is on the WHO Model List of Essential Medicines.
Proton pump inhibitors (PPIs) are drugs that lower the amount of stomach acid your body produces. Itâs a popular treatment for preventing acid reflux symptoms like chronic heartburn, and itâs more effective than other acid secretion inhibitors like H2 blockers (Tagamet, Zantac). Hospitals use PPIs to prevent stomach ulcers in 40%-70% of inpatients.