The resulting mRNA is a single-stranded copy of the gene, which next must be translated into a protein molecule. During translation, which is the second major step in gene expression, the mRNA is read according to the genetic code, which relates the DNA sequence to the amino acid sequence in proteins (Figure 2).
This group of drugs followed and largely superseded another group of medications with similar effects, but a different mode of action, called H2-receptor antagonists. PPIs are among the most widely sold drugs in the world, and the first one, omeprazole, is on the WHO Model List of Essential Medicines.
Proton Pump Inhibitor Side Effects Proton pump inhibitors (PPIs), such as Prilosec and Nexium are used to treat certain gastrointestinal disorders by reducing the amount of acid in the stomach. PPIs are among the most commonly prescribed drugs in America, and millions more are sold over the counter.