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According to my doctor, 4 hours. You can switch them up. Take acetaminophen, (Tylenol), then wait 4 hours and take Ibuprofen, wait another 4 hours and take acetaminophen and so on. :) 15 people found this useful.
Best Answer: Assuming that the two Advil you took were only 200 mg each, then you need to wait 4 hours between doses. You can not exceed 2,400 mg of ibuprofen in a day. If you need something else because the Advil is just not cutting it, you can alternate taking Advil with Tylenol. You can take 2 Extra Strength tylenol four times per 24 hours in order to stay at the 4,000 mg daily dosage limit.