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Definition of lobotomy for English Language Learners. medical : an operation in which part of the brain is cut in order to treat some mental disorders.
Surgical incision into the frontal lobe of the brain to sever one or more nerve tracts, a technique formerly used to treat certain psychiatric disorders but now rarely performed. A surgical incision into one or more of the nerve masses in the front of the brain. A lobotomy may be performed for the relief of certain mental disorders, although it has been largely abandoned in favor of less radical treatments.