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BMS-955176 is a maturation inhibitorâthe drug prevents HIV from producing complex âpolyproteinsâ that are cut up by protease enzymes and assembled into new virus particles. If approved, BMS-955176 would be the first HIV medication to work by preventing virus assembly, maturation, and release from infected cells.
Protease inhibitors (PIs) are a class of antiviral drugs that are widely used to treat HIV/AIDS and hepatitis caused by hepatitis C virus.iven the specificity of the target of these drugs there is the risk, as in antibiotics, of the development of drug-resistant mutated viruses. To reduce this risk it is common to use several different drugs together that are each aimed at different targets.