The Japanese word for Japan is æ¥æ¬, which is pronounced Nippon or Nihon and literally means the origin of the sun. The earliest record of the name Nihon appears in the Chinese historical records of the Tang dynasty, the Old Book of Tang.
Primary versus Secondary Immune Response The primary immune response occurs the first time that the immune system comes in contact with the antigen.
Immune system function is altered by many conditions which primarily impair function of other organ systems (table 1). As with primary immunodeficiency, secondary immune dysfunction leads to an increased incidence of infection and malignancy, and the occurrence of autoimmune disease.