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Definition of lobotomy for English Language Learners. medical : an operation in which part of the brain is cut in order to treat some mental disorders.
lobotomy. a form of psychosurgery consisting of cutting of nerve fibers connecting a lobe of the brain with the thalamus. In most cases the affected parts are the prefrontal or frontal lobes, the areas of the brain involved with emotion; thus the operation is referred to as prefrontal or frontal lobotomy.obotomy. a form of psychosurgery consisting of cutting of nerve fibers connecting a lobe of the brain with the thalamus. In most cases the affected parts are the prefrontal or frontal lobes, the areas of the brain involved with emotion; thus the operation is referred to as prefrontal or frontal lobotomy.