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According to my doctor, 4 hours. You can switch them up. Take acetaminophen, (Tylenol), then wait 4 hours and take Ibuprofen, wait another 4 hours and take acetaminophen and so on. :) 15 people found this useful.
Take too much, or too frequently, or with other meds containing acetaminophen, and you risk kissing your liver goodbye. Itâs the same story of you even take an approved dose, but have even one drink of alcohol. Ibuprofen, such as Advil, also kicks in quickly, and may last a touch longer than Tylenol.