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BMS-955176 is a maturation inhibitorâthe drug prevents HIV from producing complex âpolyproteinsâ that are cut up by protease enzymes and assembled into new virus particles. If approved, BMS-955176 would be the first HIV medication to work by preventing virus assembly, maturation, and release from infected cells.
Memantine, amantadine, and L-deprenyl potentiate the action of L-dopa in monoamine-depleted rats. Amantadine inhibits an early step in the viral replication process, probably viral uncoating, and also has an effect on one of the final steps of viral assembly in some strains.