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BMS-955176 is a maturation inhibitorâthe drug prevents HIV from producing complex âpolyproteinsâ that are cut up by protease enzymes and assembled into new virus particles. If approved, BMS-955176 would be the first HIV medication to work by preventing virus assembly, maturation, and release from infected cells.
The approval adds a new non-nucleoside reverse transcriptase inhibitor (NNRTI) to the list of approved anti-HIV drugs. It also increases the chances that a new combination pill, containing Edurant plus Truvada (emtricitabine/tenofovir), will be approved by the FDA.