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Definition of lobotomy for English Language Learners. medical : an operation in which part of the brain is cut in order to treat some mental disorders.
Freebase(0.00 / 0 votes)Rate this definition: Lobotomy is a neurosurgical procedure, a form of psychosurgery, also known as a leukotomy or leucotomy. It consists of cutting or scraping away most of the connections to and from the prefrontal cortex, the anterior part of the frontal lobes of the brain.