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According to my doctor, 4 hours. You can switch them up. Take acetaminophen, (Tylenol), then wait 4 hours and take Ibuprofen, wait another 4 hours and take acetaminophen and so on. :) 15 people found this useful.
Take Tylenol, 2 tablets every 4-6 hours for fever, do not take more than 8 extra-strength Tylenol (500mg) tablets in one day. Take Ibuprofen (advil, motrin), 2-3 tablets every 4-6 hours. Do not use Ibuprofen if you have a history of aspirin allergy or a stomach ulcer.