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Typically, it is possible to detect methadone in the urine for 2 to 4 days after it has been used, which implies that this is the period for which methadone stays in your system. On the other hand, the detection window of methadone in blood is approximately 24 hours, while that in saliva is about 1 to 10 days.
In urine, methadone metabolites can test positive for 2-4 days after last dose. Here, you will find a thorough review of methadone detection times, drug testing methods and addiction liability of methadone. Please leave your questions about methadone use, abuse or addiction at the end.eak levels and half life of methadone. Methadoneâs elimination half-life is between 8-59 hours. More specifically, the half-life of (R,S)-methadone is 15-60 hours, and 10-40 hours for (R)-methadone. The duration of analgesic action is between 4-8 hours.