Abstract During embryonic development, endothelial cells differentiate from a common precursor called angioblast and acquire organ-specific properties. One of the important determinants of endothelial cell differentiation is the local environment, and especially the interaction with surrounding cells.ne of the major limitations to the study of endothelial cell heterogeneity is the fact that these cells are still difficult to isolate and culture from the microcirculation of different organs, and once in culture, they tend to lose their specialized properties.
The reason temperature is important is because wines age faster at a higher temperature, and chemically, a high temperature is bad for wine. You can tell by the color of your wine if excessive heat has damaged it. The wine will look brown.
1 The greater the changes in temperature a wine suffers, the greater the premature aging of the wine from over breathing. 2  The temperature should never fluctuate more than 3Â°F (1.6Â°C) a day and 5Â°F (2.7Â°C) a year, especially with red wines, which will suffer more temperature-related problems than white wines. Wine storage temperature should not go over 75ËF (24Â°C), for longer than brief spans of time. 2  At 75Â°F, wine begins to oxidize. 3  An ideal temperature for storing a varied wine collection is 54Â°F (12.2Â°C). 4  Letting the temperature drop below 54Â°F won't hurt the wine; it'll only slow down the aging process.