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Within eukaryotes, DNA replication is controlled within the context of the cell cycle. As the cell grows and divides, it progresses through stages in the cell cycle; DNA replication takes place during the S phase (synthesis phase).
DNA replication in eukaryotes occurs only in the S phase of the cell cycle. However, pre-initiation occurs in the G1 phase. Thus, the separation of pre-initiation and activation ensures that the origin can only fire once per cell cycle.