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endocrine signaling. Signaling in which endocrine cells release hormones that act on distant target cells.
The glands that secrete hormones comprise the endocrine signaling system. The term hormone is sometimes extended to include chemicals produced by cells that affect the same cell (autocrine or intracrine signalling) or nearby cells (paracrine signalling).ome hormones are completely active when released into the bloodstream (as is the case for insulin and growth hormones), while others must be activated in specific cells through a series of activation steps that are commonly highly regulated.