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According to my doctor, 4 hours. You can switch them up. Take acetaminophen, (Tylenol), then wait 4 hours and take Ibuprofen, wait another 4 hours and take acetaminophen and so on. :) 15 people found this useful.
Maximum for tylenol is 4 Gm or 4,000 Mg and the Maximum for ibuprofen is 3.2 Gm or 3200 Mg-this is within a 24 HOUR period. 2400 Mg or 1800 Mg/24 hours is the most commonly prescribed for ibuprofen. I have taken care of TWO patients in the past; one who had tylenol toxicity and the other one had ibuprofen toxicity.