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Within eukaryotes, DNA replication is controlled within the context of the cell cycle. As the cell grows and divides, it progresses through stages in the cell cycle; DNA replication takes place during the S phase (synthesis phase).
DNA Replication. Before a cell can divide, it must duplicate all its DNA. In eukaryotes, this occurs during S phase of the cell cycle. DNA replication begins with the unzipping of the parent molecule as the hydrogen bonds between the base pairs are broken.