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Definition of lobotomy for English Language Learners. medical : an operation in which part of the brain is cut in order to treat some mental disorders.
Wiktionary(0.00 / 0 votes)Rate this definition: 1  lobotomy(Noun) A surgical operation on the frontal lobe of the brain intent on treating certain mental illnesses. 2  lobotomy(Noun) The severing of the prefrontal cortex from the thalamic region of the brain. 3  lobotomy(Noun) The severing of the sympathetic nerve trunk.