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In human fertilization, two 1n haploid cellsâan ovum (female gamete) and a sperm cell (male gamete)âcombine to form a single 2n diploid cell called the zygote.n fungi, the sexual fusion of haploid cells is called karyogamy. The result of karyogamy is a diploid cell called a zygote or zygospore. This cell may then enter meiosis or mitosis depending on the life cycle of the species.
The First Cell Division. The final steps in zygote formation include replication of the male and female DNA and the alignment of chromosomes in preparation for the first cell division through mitosis (mi-toâsis). The chromosomes assume a formation called a cleavage spindle, which is a phase of mitosis.