The proteins made by varying APOE alleles handle this transport function differently. Outside the brain, APOE4 can increase the risk of atherosclerosis (i.e., hardening of the arteries) and stroke , which may explain why APOE4 is a risk factor for vascular causes of cognitive impairment and dementia .
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The Cincinnati-based retailer said it is closing 14 stores nationwide, including at Richmond Town Square in Richmond Heights, which employs 105 people, as part of a nationwide restructuring designed to make the company more responsive to customers. Clearance sales begin Monday, Jan. 12.