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According to my doctor, 4 hours. You can switch them up. Take acetaminophen, (Tylenol), then wait 4 hours and take Ibuprofen, wait another 4 hours and take acetaminophen and so on. :) 15 people found this useful.
Best Answer: Ibuprofen and aleve are both anti inflammatory medicine...very similar. It would be the same as taking the next dose of ibuprofen.I think that is six hours, but you would be safe to take some tylenol in four hours.If it is for a headache I use Excedrin extra strength. It seems to work wonders on my headaches.