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Bactrim is a sulfa-based antibiotic and is not a penicillin-based medicine, according to RxList. However, a patient should discuss all allergies with a doctor to determine what drugs can and cannot be taken. Continue Reading.
Bactrim works against bacteria in the following types of infections: 1  Urinary tract infections (UTIs) caused by E. coli, Klebsiella, Enterobacter, Morganella morganii, Proteus mirabilis, and Proteus vulgaris.he drug is a combination of two antibiotics: It's one part trimethoprim (a synthetic drug), and five parts sulfamethoxazole (a sulfonamide drug).