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After treatment, a small number of people still have some symptoms, such as muscle aches and fatigue. The cause of these continuing symptoms, known as post-treatment Lyme disease syndrome, is unknown, and treating with more antibiotics doesn't help.Some experts believe that certain people who get Lyme disease are predisposed to develop an autoimmune response that contributes to their symptoms.More research is needed.he cause of these continuing symptoms, known as post-treatment Lyme disease syndrome, is unknown, and treating with more antibiotics doesn't help. Some experts believe that certain people who get Lyme disease are predisposed to develop an autoimmune response that contributes to their symptoms. More research is needed.
Just curious what your thoughts are about if Lyme can come back after treatment. I had Lyme about 5 years ago and was treated with oral antibiotics and a Central line for about 3 months.es it can come back. I was sick for 5 years and got well after 2 1/2 years of treatment. I stayed well for over 3 years and considered myself cured. I had no symptoms during that time.