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Typically, it is possible to detect methadone in the urine for 2 to 4 days after it has been used, which implies that this is the period for which methadone stays in your system. On the other hand, the detection window of methadone in blood is approximately 24 hours, while that in saliva is about 1 to 10 days.
Hello Vicky. Although your system can rid itself of the methadone within about 72 hours, traces of it will still be detected in your urine for up to 3 weeks, and it can be detected even longer than 3 weeks on blood tests. It is a long acting medication, metabolizes slowly and recedes from the receptors sites slowly.