In the simplest of terms, a drug's volume of distribution is that volume of bodily fluid into which a drug dose is dissolved. Therefore, if we know the dose that was given, and we can measure the serum level (concentration), then we can calculate a volume: Volume of distribution = Dose / drug concentration.
As soon as you can make the reservation, do it, but the general consensus is at least three to six months in advance of the date. By three months out, couples have a good idea how many guests will be attending and they can plan a menu that doesnât conflict with their wedding day.
During the final week of rehearsal, Equity permits the actor to rehearse 10 hours out of a 12 hour day (referred in the trade as 10/12), provided the performer has a 12 hour break between the end of one rehearsal and beginning of the next.