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BMS-955176 is a maturation inhibitorâthe drug prevents HIV from producing complex âpolyproteinsâ that are cut up by protease enzymes and assembled into new virus particles. If approved, BMS-955176 would be the first HIV medication to work by preventing virus assembly, maturation, and release from infected cells.
1 Clarithromycin and ethambutol with or without clofazimine for the treatment of bacteremic Mycobacterium avium complex disease in patients with HIV infection. 2  AIDS. 3  Mar 1997;11(3):311-317. 4  Available at http://www.ncbi.nlm.nih.gov/pubmed/9147422. A prospective, randomized trial examining the efficacy and safety of clarithromycin in combination with ethambutol, rifabutin, or both for the treatment of disseminated Mycobacterium avium complex disease in persons with acquired immunodeficiency syndrome. 2  Clin Infect Dis. 3  Nov 1 2003;37(9):1234-1243.