The proteins made by varying APOE alleles handle this transport function differently. Outside the brain, APOE4 can increase the risk of atherosclerosis (i.e., hardening of the arteries) and stroke , which may explain why APOE4 is a risk factor for vascular causes of cognitive impairment and dementia .
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1014 Vine Street, Cincinnati, OH 45202 Map. One of the nation's largest grocery retailers, headquartered in Cincinnati, Ohio; runs grocery & multi-department stores, convenience stores & mall jewelry stores; brands include Kroger, Ralphs, King Soopers, Dillons, Smith's Food & Drug Stores etc. Retail Chains Supermarkets.