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Yes: You can take them together. Allegra 24 hour is a nonsedating antihistamine and Sudafed PE is a decongestant. This would be similar to taking allegra D. What you do not want to do is take Allegra D with sudafed, then you would get too much decongestant.Also you want to avoid decongestants if you have certain conditions like hypertension.Also don't take the sudafed at bedtime....Read more.hat you do not want to do is take Allegra D with sudafed, then you would get too much decongestant. Also you want to avoid decongestants if you have certain conditions like hypertension. Also don't take the sudafed at bedtime. ...Read more.
A person can take Mucinex and Sudafed at the same time; according to Drugs.com, there are no interactions between the two medications, but it is always important for individuals who are planning on taking the medications together to consult with a professional pharmacist.