Anybody want to share a bottle of red? A group of Chinese winemakers have claimed the new world record for the worldâs biggest ever bottle of wine. The 15ft high bottle contains an astonishing 1,850 litres of wine, produced by Wang Chen Wines in Liaoning, northern China. Thatâs over three times the amount held by the previous record-holders, Austrian winemakers Kracher, whose bottle held 490 litres of Grande Cuvee TBA NV No.7 2005.
Antimetabolites are a type of chemo drug that interferes with the normal metabolism of cells, which makes them stop growing. Doctors often use them to treat leukemia and cancer in the breasts, ovaries, and intestines. Drugs in this group include 5-fluorouracil, 6-mercaptopurine, cytarabine, gemcitabine, and methotrexate, among many others.
Antimetabolite drugs were among the first effective chemotherapeutic agents discovered and are folic acid, pyrimidine or purine analogues. They are characterized by low molecular weights. They have similar structures as naturally occurring molecules used in nucleic acid (DNA and RNA) synthesis. Antimetabolites are similar to chemicals needed for normal biochemical activity, but differ enough so that they interfere with normal cell function. Generally, antimetabolites induce cell death during the S phase of cell growth when incorporated into RNA and DNA or inhibit enzymes needed for nucleic acid production.