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Bactrim is a sulfa-based antibiotic and is not a penicillin-based medicine, according to RxList. However, a patient should discuss all allergies with a doctor to determine what drugs can and cannot be taken. Continue Reading.
Dr. Jeffrey Juchau Dr. Juchau. Unclear Question: there is no relationship between Bactrim, a sulfa drug and Amoxicillin, a penicillin based drug. Your body does not become immune to either drug. You may develop an allergy, but they are not cross reactive. Bacteria may develop resistance, which you could call immunity, to an antibiotic.