Blood clot. Blood clots that form in the veins of the legs can stop the return flow of blood from the legs back to the heart and cause swelling in the ankles and feet. Blood clots can be either superficial (occurring in the veins just beneath the skin), or deep (a condition known as deep vein thrombosis).Deep clots can block one or more of the major veins of the legs. These blood clots can be life-threatening if they break loose and travel to the heart and lungs.lood clots can be either superficial (occurring in the veins just beneath the skin), or deep (a condition known as deep vein thrombosis). Deep clots can block one or more of the major veins of the legs. These blood clots can be life-threatening if they break loose and travel to the heart and lungs.
Muscle Aches and Pains Are Part of Life. Muscle pain and related aches can happen to anyone. They usually affect the support structures that allow you to move about in daily life: bones, muscles, ligaments, and tendons. Musculoskeletal pain can be caused by injury, poor posture, repetitive motions, overuse, and just plain old wear and tear. Your entire body might ache, or you might have pain in a specific spot from, for example, a pulled muscle or twisted ankle. If the pain is strong, it may even keep you from sleeping and leave you fatigued, too. Fortunately there are many ways to treat musculoskeletal pain.
The specific cause of body aches (myalgia) are the interleukins, which are primarily produced by the macrophages. These interleukins cause pain, body aches, hypersensitivity of the nerves, etc. Some of the interleukins (such as IL-2) cause the fever seen during the flu, and probably the headaches. Since these interleukins are produced in response many different kinds of bacterial and viral infections, symptoms such as fever, myalgia, and headaches can be seen in infections by many different etiologic agents.