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Yes: You can take them together. Allegra 24 hour is a nonsedating antihistamine and Sudafed PE is a decongestant. This would be similar to taking allegra D. What you do not want to do is take Allegra D with sudafed, then you would get too much decongestant.Also you want to avoid decongestants if you have certain conditions like hypertension.Also don't take the sudafed at bedtime....Read more.hat you do not want to do is take Allegra D with sudafed, then you would get too much decongestant. Also you want to avoid decongestants if you have certain conditions like hypertension. Also don't take the sudafed at bedtime. ...Read more.
Oral Decongestants. Sudafed (pseudoephedrine) is a common choice that can also be taken with antihistamines like Allegra, Claritin and Zyrtec and be effective for post nasal drip cough relief. Any medication that has the letter âDâ behind it already contains pseudoephedrine; example: Allegra-D or Claritin-D.