The proteins made by varying APOE alleles handle this transport function differently. Outside the brain, APOE4 can increase the risk of atherosclerosis (i.e., hardening of the arteries) and stroke , which may explain why APOE4 is a risk factor for vascular causes of cognitive impairment and dementia .
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In 1988, after Associated Dry Goods was acquired by May department stores, it consolidated the historic and once proudly independent Pogue's with L. S. Ayres & Co. of Indianapolis, and Pogue's name, practically venerated in Cincinnati, disappeared from the city's shopping scene.