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Within eukaryotes, DNA replication is controlled within the context of the cell cycle. As the cell grows and divides, it progresses through stages in the cell cycle; DNA replication takes place during the S phase (synthesis phase).
DNA replication takes place during the synthesis phase of the cell cycle. The cell also forms a second centrosome during this phase. The synthesis phase is often written as S phase. It occurs after the first growth (G1) phase, and therefore about midway through interphase.