The proteins made by varying APOE alleles handle this transport function differently. Outside the brain, APOE4 can increase the risk of atherosclerosis (i.e., hardening of the arteries) and stroke , which may explain why APOE4 is a risk factor for vascular causes of cognitive impairment and dementia .
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List of companies in Greater Cincinnati. Procter & Gamble headquarters. This is a list of major companies and organizations in Greater Cincinnati, through corporate or subsidiary headquarters or through significant operational and employment presence near Cincinnati, Ohio, USA. Altogether, nine Fortune 500 companies and fifteen Fortune 1000 companies have headquarters in the Cincinnati area.