Pasquin and Allen would later work again on the films Jungle 2 Jungle and Joe Somebody, and on the TV show Last Man Standing. The film was followed by two sequels, The Santa Clause 2 (2002) and The Santa Clause 3: The Escape Clause (2006). In comparison to the original, the former received mixed critical response while the latter was panned by most critics.
Chang and Eng Bunker fathered a total of 21 children, and their descendants now number more than 1,500. Many of their descendants continue to reside in the vicinity of Mount Airy, and descendants of both brothers continue to hold joint reunions.
Blackmon has twin daughters and there have been several sets of twins in the family since Chang and Eng, he said, though none were conjoined. Eng Bunker II and his twin brother, Chang Bunker II, were one of a few sets of twins present at the reunion. The 73-year-olds were the first set of twins to be born since the Siamese twins for whom they were named.