The proteins made by varying APOE alleles handle this transport function differently. Outside the brain, APOE4 can increase the risk of atherosclerosis (i.e., hardening of the arteries) and stroke , which may explain why APOE4 is a risk factor for vascular causes of cognitive impairment and dementia .
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But analysts are skeptical the Cincinnati-based retailer wants to double-down on a traditional department store concept. Belk, based in Charlotte, North Carolina, operates 297 department stores throughout the Southeast from Maryland to Texas. Belk's nearest store to Cincinnati is in Ashland, Kentucky. Earlier this week, Belk reported a $146.1 million profit on revenues of $4.1 billion, but disclosed it was reviewing its long-term strategic plan and hired investment banker Goldman Sachs to weigh its options.