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Within eukaryotes, DNA replication is controlled within the context of the cell cycle. As the cell grows and divides, it progresses through stages in the cell cycle; DNA replication takes place during the S phase (synthesis phase).
Best Answer: DNA replication occurs in the Interphase (S Phase of cell reproduction), and must occur BEFORE, not during, mitosis. The cell cycle: 1. Interphase consists of three growing stages: Gap 1 (G1 phase, which also includes Gzero step for some cells)), Synthesis (S phase), and Gap 2 (G2 phase). 2.