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Bactrim is a sulfa-based antibiotic and is not a penicillin-based medicine, according to RxList. However, a patient should discuss all allergies with a doctor to determine what drugs can and cannot be taken. Continue Reading.
Answers. Best Answer: Sulfa antibiotics such as Bactrim do NOT cover for the strep infections. They do cover most bacterium that cause sinusitis, however. If you truly think you have strep throat, you should see your doctor for a throat culture and emperic starting of a penicillin, omnicef, or keflex. Source(s): harley_pa Â· 6 years ago. Thumbs up.