The melting point (or, rarely, liquefaction point) of a solid is the temperature at which it changes state from solid to liquid at atmospheric pressure.At the melting point the solid and liquid phase exist in equilibrium.he melting point (or, rarely, liquefaction point) of a solid is the temperature at which it changes state from solid to liquid at atmospheric pressure.
Alendronate (Fosamax, Fosamax Plus D, and generic), the first bisphosphonate approved by the Food and Drug Administration for the treatment and prevention of osteoporosis, came on the market in 1995 and proved to be a moneymaker, bringing in nearly $3.2 billion in 2005.
The trial included 3,889 patients with evidence of osteoporosis who were randomly assigned to a single 15-minute infusion of zoledronic acid (5 mg), while 3,876 patients were randomized to placebo treatment. All patients received daily oral calcium (1,000 to 1,500 mg) and vitamin D (400 to 1,200 IU).