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Definition of lobotomy for English Language Learners. medical : an operation in which part of the brain is cut in order to treat some mental disorders.
Lobotomy: Definition, Procedure & History. A lobotomy severs the connections in the brain's prefrontal lobe, the area highlighted in this illustration. Lobotomy, also known as leucotomy, is a neurosurgical operation that involves severing connections in the brain's prefrontal lobe, according to Encyclopaedia Britannica. Lobotomies have always been controversial, but were widely performed for more than two decades as treatment for schizophrenia, manic depression and bipolar disorder, among other mental illnesses.