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Typically, it is possible to detect methadone in the urine for 2 to 4 days after it has been used, which implies that this is the period for which methadone stays in your system. On the other hand, the detection window of methadone in blood is approximately 24 hours, while that in saliva is about 1 to 10 days.
Interpretation. 1  The clearance half-life of methadone averages 30 hours. 2  Patients who are taking methadone for therapeutic purposes excrete both parent methadone and metabolite in their urine. The absolute concentration found in a patientâs urine sample can be highly variable; however, patients who are known to be compliant with their methadone therapy have ratios of EDDP:methadone >0.60.