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Bactrim is a sulfa-based antibiotic and is not a penicillin-based medicine, according to RxList. However, a patient should discuss all allergies with a doctor to determine what drugs can and cannot be taken. Continue Reading.
Bactrim works against bacteria in the following types of infections: 1  Urinary tract infections (UTIs) caused by E. coli, Klebsiella, Enterobacter, Morganella morganii, Proteus mirabilis, and Proteus vulgaris.actrim DS tablets are white and oval, containing 160 mg of trimethoprim and 800 mg of sulfamethoxazole. Take the medication as directed by your doctor until you finish the prescription, even if you feel better. Failure to do so may help create bacteria that are resistant to treatment.