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Typically, it is possible to detect methadone in the urine for 2 to 4 days after it has been used, which implies that this is the period for which methadone stays in your system. On the other hand, the detection window of methadone in blood is approximately 24 hours, while that in saliva is about 1 to 10 days.
âThe duration of analgesic action of Methadone is 4 to 8 hours (based on single-dose studies) but the plasma elimination half-life is 8 to 59 hours. âSteady-state plasma concentrations, and full analgesic effects, are not attained until at least 3 to 5 days on a dose, and may take longer in some patients.