The proteins made by varying APOE alleles handle this transport function differently. Outside the brain, APOE4 can increase the risk of atherosclerosis (i.e., hardening of the arteries) and stroke , which may explain why APOE4 is a risk factor for vascular causes of cognitive impairment and dementia .
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The Cincinnati regionâs largest privately held companies range from local food icons to huge construction companies to operators of data centers. After you read the list, scroll to the bottom to see who's new and who fell off the list. Also see how the list is compiled.