The melting point (or, rarely, liquefaction point) of a solid is the temperature at which it changes state from solid to liquid at atmospheric pressure.At the melting point the solid and liquid phase exist in equilibrium.he melting point (or, rarely, liquefaction point) of a solid is the temperature at which it changes state from solid to liquid at atmospheric pressure.
Alendronate (Fosamax, Fosamax Plus D, and generic), the first bisphosphonate approved by the Food and Drug Administration for the treatment and prevention of osteoporosis, came on the market in 1995 and proved to be a moneymaker, bringing in nearly $3.2 billion in 2005.
FDA Approves Once-A-Year Infusion for Osteoporosis. EAST HANOVER, N.J., Aug. 20. -- The FDA has approved a once-yearly formulation of zoledronic acid (Reclast) for osteoporosis in postmenopausal women, Novartis announced. The drug, administered in a single 15-minute-long intravenous infusion, was already approved for treatment of Paget's disease.