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Definition of lobotomy for English Language Learners. medical : an operation in which part of the brain is cut in order to treat some mental disorders.
View full size image. Lobotomy, also known as leucotomy, is a neurosurgical operation that involves severing connections in the brain's prefrontal lobe, according to Encyclopaedia Britannica.iew full size image. Lobotomy, also known as leucotomy, is a neurosurgical operation that involves severing connections in the brain's prefrontal lobe, according to Encyclopaedia Britannica.