The Japanese word for Japan is æ¥æ¬, which is pronounced Nippon or Nihon and literally means the origin of the sun. The earliest record of the name Nihon appears in the Chinese historical records of the Tang dynasty, the Old Book of Tang.
The secondary immune response occurs the second time (3rd, 4th, etc.) the person is exposed to the same antigen. At this point immunological memory has been established and the immune system can start making antibodies immediately.
Immune system function is altered by many conditions which primarily impair function of other organ systems (table 1). As with primary immunodeficiency, secondary immune dysfunction leads to an increased incidence of infection and malignancy, and the occurrence of autoimmune disease.