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According to my doctor, 4 hours. You can switch them up. Take acetaminophen, (Tylenol), then wait 4 hours and take Ibuprofen, wait another 4 hours and take acetaminophen and so on. :) 15 people found this useful.
actually you should be able to give her the ibuprofen at 6:30 and the tylenol again at 8:30. You can alternate them every two hours for fever. 1 mom found this helpful