The proteins made by varying APOE alleles handle this transport function differently. Outside the brain, APOE4 can increase the risk of atherosclerosis (i.e., hardening of the arteries) and stroke , which may explain why APOE4 is a risk factor for vascular causes of cognitive impairment and dementia .
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Advanced software and services for the procurement and management of business licenses, permits, and tax registrations. Learn More. Cincinnati, Ohio Business License & Business Permit List: Please note that the sample list below is for illustration purposes only and may contain licenses that are not currently imposed by the jurisdiction shown.