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According to my doctor, 4 hours. You can switch them up. Take acetaminophen, (Tylenol), then wait 4 hours and take Ibuprofen, wait another 4 hours and take acetaminophen and so on. :) 15 people found this useful.
Then I take tylenol again in 2 or 3 hours followed by the ibuprofen 2 or 3 hours later so that there are at least 4 hours between Tylenol and 4 hours between the ibuprofen. so say: 12:00 take 2 tylenol 2:00 take 2 ibuprofen 4:00 take 2 tylenol 6:00 take 2 ibuprofen Hope your shoulder feels better soon.