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BMS-955176 is a maturation inhibitorâthe drug prevents HIV from producing complex âpolyproteinsâ that are cut up by protease enzymes and assembled into new virus particles. If approved, BMS-955176 would be the first HIV medication to work by preventing virus assembly, maturation, and release from infected cells.
There are currently five categories of HIV antiviral drugs available that have FDA (U.S. Food and Drug Administration) approval. Fusion inhibitors work outside the CD4 cell by inhibiting HIV from joining, or fusing, with the cell.