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Hox gene. n. Any of a group of homeobox genes that exist as clusters in animals, especially in vertebrates, and determine the identity and locations of body parts along the anterior-posterior body axis in a developing fetus or larva. [From h(omeob)ox 1  .]. Facebook.
1) The vertebrate homeotic complex comprises four distinct Hox gene clusters (Hox A, B, C, D) that are organized into thirteen homology (or paralogue) groups. 2) The chromosomal organization of the genes in each Hox cluster reflects its anterior-posterior expression in the body plan (spatial colinearity).Unlike in Drosophila, vertebrate Hox genes are also temporally colinear and are expressed in an anterior to posterior direction.In general, members of the same paralogue group are expressed at the same time and have the same anterior boundary of expression.n vertebrates, the main evidence of segmentation is in the vertebral column. The head, the fore-and hindlimbs are later adaptations onto the early vertebrate skeleton. The earliest expression studies focused on the expression of hox genes in the prevertebra of mid-gestation embryos.