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According to my doctor, 4 hours. You can switch them up. Take acetaminophen, (Tylenol), then wait 4 hours and take Ibuprofen, wait another 4 hours and take acetaminophen and so on. :) 15 people found this useful.
Soon after taking an overdose of acetaminophen, the person may have no symptoms from taking a toxic amount. They may remain symptom free for up to 24 hours after taking a toxic overdose of acetaminophen. After this initial period, the following symptoms are common in acetaminophen (Tylenol) poisoning: Nausea.