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Definition of lobotomy for English Language Learners. medical : an operation in which part of the brain is cut in order to treat some mental disorders.
Wiktionary (0.00 / 0 votes) Rate this definition: lobotomy (Noun). A surgical operation on the frontal lobe of the brain intent on treating certain mental illnesses. lobotomy (Noun). The severing of the prefrontal cortex from the thalamic region of the brain. lobotomy (Noun). The severing of the sympathetic nerve trunk.