Other benefits of melatonin include general neuroprotective effects, as melatonin is a powerful antioxidant. Melatonin also has several anti-cancer properties, and is currently being investigated for its role in fighting breast cancer.
The date of substantial completion is extremely important, because it determines the date that a contractor is no longer fully liable for delayed completion or for minor incomplete details. After substantial completion, the owner again becomes responsible for the property, i.e., security, utilities, etc.
Something substantial is large in size, number, or amount: If you want to say someone spent a lot of money without being too specific, you could say they spent a substantial amount of money. The adjective substantial derives from the Latin substantia substance, which means stuff. A substantial meal is large enough to satisfy hunger. A substantial structure is strongly made or built. And a substantial man possesses wealth and property. Related to this last sense, a man of substance refers to a wealthy man with property.