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Manufacturers universally tell you to refrigerate mayonnaise once opened, though, because it helps preserve the flavor. Warmth causes mayonnaise to break down after a while, and it gets to the point where it just tastes oily. Homemade mayonnaise, of course, is a different matter. With its use of raw eggs, it is highly perishable and should be consumed immediately or refrigerated and finished off very shortly.
The presence of eggs is usually a sure sign a food is perishable and needs to be refrigerated. This is not the case with store-bought mayonnaise. If you rush a jar of mayonnaise back to the refrigerator once the seal is broken, you should know you don't need to rush it back. The mayonnaise will not spoil if you leave it on the counter. Homemade mayonnaise is another story.