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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
cholinergic crisis, a pronounced muscular weakness and respiratory paralysis caused by excessive acetylcholine, often apparent in patients suffering from myasthenia gravis as a result of overmedication with anticholinesterase drugs. Nicotinic crisis Muscle weakness, fasciculations, cramping and dysphagia, due to overdepolarization at the neuromuscular junction. See Tensilon test &nbsp. ;.