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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
Animal models of Parkinsonâs disease and schizophrenia have found that dopamine plays an important role in regulating sleep. Mice altered to have high dopamine levels in their brains are more sensitive than normal to caffeine and modafinil and have a stronger recovery reaction to sleep deprivation: following prolonged wakefulness they have move slow-wave sleep and total sleep than other mice.