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This type of pain is usually localized, affecting just a few muscles or a small part of your body. Systemic muscle pain â pain throughout your whole body â is more often the result of an infection, an illness or a side effect of a medication. Common causes of muscle pain include: Chronic exertional compartment syndrome. Chronic fatigue syndrome.
Joint tenderness, sensitivity of the joints to touch, can also occur in people with OA. Pain and tenderness can be caused by: bones rubbing against each other; inflammation in the joints; bone spurs (bony growths) pinched nerves caused by swelling and displacement of joint tissue; Swelling. Swelling is more common in people with RA than OA.