Mutation is a change in DNA, the hereditary material of life. An organism's DNA affects how it looks, how it behaves, and its physiology  all aspects of its life. So a change in an organism's DNA can cause changes in all aspects of its life.
continuously variable transmission (CVT)=An automatic transmission that can change seamlessly through an infinite number of effective gear ratios between maximum and minimum values. Automatic transmission= Automatically change gear ratios as the vehicle moves, freeing the driver from having to shift gears manually.
Positioning the tip of a central venous catheter (CVC) within the superior vena cava (SVC) at or just above the level of the carina is generally considered acceptable for most short-term uses, such as fluid administration or monitoring of central venous pressure.