Providers and consumers should realize that isotretinoin is a potent drug with the potential to cause birth defects and reserve its use for severe recalcitrant nodular acne. Isotretinoin is not for use in mild forms of acne and should not be shared among family members.
Most orbital motorways (or beltways) are purpose-built major highways around a town or city, typically without either signals or road or railroad crossings. In the United States, beltways are commonly parts of the Interstate Highway System. Similar roads in the United Kingdom are often called orbital motorways.
A highway is a public road with two or more lanes per direction, and have dual carriageways (divided highway), limited access and have grade-separated junctions. The first highway paved with portland cement, or concrete, is built near Pine Bluff, Arkansas, 22 years after Bellefontaine, Ohio, first paved its Main Street with concrete.