Project managed by RPC Oevel who provide the single point of contact for the customer, RPC Oevel are supplying 300 and 675ml bottles from their standard range, while RPC Kutenholz are producing two custom-moulded designs.
Production of Thrombopoietin. The liver is the major producer of Thrombopoietin in the human body. It has special cells that handle the production of several hormones including Thrombopoietin. Both the parenchymal cells and sinusoidal cells of the liver play a major role in the production of this hormone.
Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated Factor X (Xa). The activity of factor Xa is greatly enhanced by binding to activated Factor V (Va), termed the prothrombinase complex. Prothrombin is produced in the liver and is co-translationally modified in a vitamin K-dependent reaction that converts ten glutamic acids on prothrombin to gamma-carboxyglutamic acid (Gla).