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1 Epstein-Barr virus (EBV) is a contagious infection that causes infectious mononucleosis. 2  The illness is spread by casual contact, usually via saliva. 3  Mono has an incubation period of 4 to 6 weeks. The illness is spread by casual contact, usually via saliva. 2  Mono has an incubation period of 4 to 6 weeks. 3  The vast majority of adults have antibodies against EBV, meaning they have been infected with the virus and are immune to mono.
It causes infectious mononucleosis, or mono. Mono is passed from person to person through saliva. Symptoms usually appear within four to six weeks after exposure and ease in one to two months. If you have mono, you may have a high level of a type of white blood cell called a lymphocyte in your blood.