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Rating Newest Oldest. Best Answer: It certainly can. The vagina has a balance between bacteria and yeast. If the penicillin kills off most of the bacteria, the yeast will multiply and cause a yeast infection; itching is one of the most common symptoms. There are OTC medications for yeast infections, but I also recommend yogurt or lactobacillus acidopholus (the buggie that makes yogurt).
Drug allergies can be hard to diagnose. An allergy to penicillin-type drugs is the only one that can be definitively diagnosed through a skin test. Some allergic reactions to drugs-particularly rashes, hives and asthma-can resemble certain diseases.s a result, the next time you take the drug, your immune system may see it as an invader, and youâll develop symptoms as your body releases chemicals to defend against it. These symptoms may include: 1  Skin rash or hives. 2  Itching. 3  Wheezing or other breathing problems. 4  Swelling. 5  Vomiting.