Pathogenic mutation. p-a rare allele that exist at a frequency of less than .01 in the human population. v- a change in DNA sequence that may or may not be pathogenic. patho- change in DNA sequence that has an effect on the encoded protein of gene expression that results in disease.
In the fall of 1791, Washington learned of the newly patented automated milling system invented by Oliver Evans. Evans received U.S. Patent #3 for his groundbreaking system, which moved wheat and flour throughout the mill without the need of manual labor. Washington purchased a license for the patent and had the milling system installed in his gristmill. Today, this milling system is faithfully interpreted, fully-functioning, and open to guests on a seasonal basis.
He was the first sheriff of Centre Co. October 28, 1800, he built Elk Mills, at Millheim (later Mussers), 1817, and rebuilt Spring Mills in 1822. He took John Forster into partnership and the firm of Duncan & Forster was known all through western Pennsylvania.