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Bile acid sequestrants are polymeric compounds that serve as ion-exchange resins. Bile acid sequestrants exchange anions such as chloride ions for bile acids.By doing so, they bind bile acids and sequester them from the enterohepatic circulation. The liver then produces more bile acids to replace those that have been lost.ile acid sequestrants are large polymeric structures, and they are not significantly absorbed from the gut into the bloodstream. Thus, bile acid sequestrants, along with any bile acids bound to the drug, are excreted via the feces after passage through the gastrointestinal tract.
Bile is a green liquid made by the liver composed of water, cholesterol, salts and lecithin. Bile assists in the breakdown and absorption of fats from food. When you eat, especially when you eat fatty foods, the gallbladder is stimulated to contract and empty its contents into the intestine.When bile mixes with food, it emulsifies fats and certain vitamins such as A, D, E, and K aiding in absorption.If the gallbladder has concentrated the bile too much, stones can form. This is a condition called cholelithiasis. Most gallstones are asymptomatic, but about ten percent of people will develop symptoms.hen bile mixes with food, it emulsifies fats and certain vitamins such as A, D, E, and K aiding in absorption. If the gallbladder has concentrated the bile too much, stones can form. This is a condition called cholelithiasis. Most gallstones are asymptomatic, but about ten percent of people will develop symptoms.