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Answer Wiki. Summary: peak running performance after donating blood may be impacted for up to 1-2 weeks after donating 1 pint of blood, but is most noticeably impacted within the first 1-2 days after donating when attempting to perform at peak levels during endurance activities.
Researchers could detect endorphins in peopleâs blood after a run, but those endorphins were part of the bodyâs stress response and could not travel from the blood to the brain. They were not responsible for elevating oneâs mood. So for more than 30 years, the runnerâs high remained an unproved hypothesis.