Pathogenic mutation. p-a rare allele that exist at a frequency of less than .01 in the human population. v- a change in DNA sequence that may or may not be pathogenic. patho- change in DNA sequence that has an effect on the encoded protein of gene expression that results in disease.
In the fall of 1791, Washington learned of the newly patented automated milling system invented by Oliver Evans. Evans received U.S. Patent #3 for his groundbreaking system, which moved wheat and flour throughout the mill without the need of manual labor. Washington purchased a license for the patent and had the milling system installed in his gristmill. Today, this milling system is faithfully interpreted, fully-functioning, and open to guests on a seasonal basis.
Oliver's invention allowed grist mills to produce a higher quality flour-with much lower labor expenses. The Wye Grist Mill was one of the first mills to be automated with the Evans process, still in use today at the Wye Grist Mill. Oliver Evans also invented the high pressure steam engine, and was the first to design and build a wheeled vehicle powered by an engine.