Pathogenic mutation. p-a rare allele that exist at a frequency of less than .01 in the human population. v- a change in DNA sequence that may or may not be pathogenic. patho- change in DNA sequence that has an effect on the encoded protein of gene expression that results in disease.
In the fall of 1791, Washington learned of the newly patented automated milling system invented by Oliver Evans. Evans received U.S. Patent #3 for his groundbreaking system, which moved wheat and flour throughout the mill without the need of manual labor. Washington purchased a license for the patent and had the milling system installed in his gristmill. Today, this milling system is faithfully interpreted, fully-functioning, and open to guests on a seasonal basis.
In 1790, Samuel Slater opened the first successful water powered cotton mill in America, Slater Mill, at Pawtucket Falls. This mill was powered by the waters of the Blackstone River. Many other mills appeared along the Blackstone River over time making it an important part of American industry. The industrialization also led to the river being identified by the end of the 20th century as the primary source of Narragansett Bay pollution.