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Clindamycin does not interact with coumadin directly, though clindamycin is shown to cause liver damage, If this is the case the coumadin can increase INR greater than expected..Regards, kindly click ACCEPT if i have answered to your satisfation, a positive feedback and a bonus will be highly appreciated..esolved Question: my mother take coumadin and was given clindamycin for a tooth infection. Her INR is now 4.8. Her dentist told her that the antibiotic should not interact with her coumadin.
Coumadin Â® (warfarin sodium) is a prescription anticoagulant medication used to prevent and treat blood clots. It is known as a narrow therapeutic index medication, which means that there is little difference between the effective dosing range and the toxic dosing range.pecial care must be taken when using generic versions of such medications. Coumadin is manufactured by Bristol-Myers Squibb Company. The patents for the drug have long expired, and generic Coumadin is now available.