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This type of pain is usually localized, affecting just a few muscles or a small part of your body. Systemic muscle pain â pain throughout your whole body â is more often the result of an infection, an illness or a side effect of a medication. Common causes of muscle pain include: Chronic exertional compartment syndrome. Chronic fatigue syndrome.
Inflammation: Generalized inflammation or that associated with inflammatory arthritis (autoimmune) can cause pain and stiffness in the ligaments and tendons around the knee. If there's fluid in the joint, tapping this can be important as are xrays and blood tests.