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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Multiple sclerosis (disease that affects the brain and spinal cord, causing weakness, coordination and balance difficulties, and other problems). Muscle breakdown (rhabdomyolysis). Muscular dystrophy (inherited disorder that causes progressive loss of muscle tissue and muscle weakness).Myasthenia gravis (autoimmune neuromuscular disorder that causes muscle weakness). Polymyositis (widespread inflammation and weakness of muscles).uscle breakdown (rhabdomyolysis). Muscular dystrophy (inherited disorder that causes progressive loss of muscle tissue and muscle weakness). Myasthenia gravis (autoimmune neuromuscular disorder that causes muscle weakness). Polymyositis (widespread inflammation and weakness of muscles).