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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Weakness of smooth muscle due to age or illness, inadequate dietary fiber, inadequate fluid intake, failure to respond to defecation reflex, immobility, neurologic disorders, some antacids or iron medications, obstructions caused by tumors or strictures.