Mutation is a change in DNA, the hereditary material of life. An organism's DNA affects how it looks, how it behaves, and its physiology  all aspects of its life. So a change in an organism's DNA can cause changes in all aspects of its life.
continuously variable transmission (CVT)=An automatic transmission that can change seamlessly through an infinite number of effective gear ratios between maximum and minimum values. Automatic transmission= Automatically change gear ratios as the vehicle moves, freeing the driver from having to shift gears manually.
Significant: Chronic venous stasis (cvi) is a result of long standing venous insufficiency due to malfunctioning of the valves of either the superficial, deep or both systems of veins. Chronic arterial insufficiency is due to long standing decrease arterial blood flow into either the legs or arms.