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1 Epstein-Barr virus (EBV) is a contagious infection that causes infectious mononucleosis. 2  The illness is spread by casual contact, usually via saliva. 3  Mono has an incubation period of 4 to 6 weeks. The illness is spread by casual contact, usually via saliva. 2  Mono has an incubation period of 4 to 6 weeks. 3  The vast majority of adults have antibodies against EBV, meaning they have been infected with the virus and are immune to mono.
Pathogenesis of Infectious Mononucleosis. EBV transmission occurs predominantly through. exposure to infected saliva, often as a result of. kissing and less commonly by means of sexual. transmission.6 The incubation period, from the. time of initial exposure to the onset of symptoms, is estimated at 30 to 50 days.