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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Causes may include infection and injury. Muscular dystrophy is a group of progressive muscle disorders caused by genetic defects. Symptoms may start with weakening of the muscles closest to the trunk, muscle enlargement, and clumsiness, and progress to severe muscle deterioration and muscle contraction..