Mutation is a change in DNA, the hereditary material of life. An organism's DNA affects how it looks, how it behaves, and its physiology  all aspects of its life. So a change in an organism's DNA can cause changes in all aspects of its life.
continuously variable transmission (CVT)=An automatic transmission that can change seamlessly through an infinite number of effective gear ratios between maximum and minimum values. Automatic transmission= Automatically change gear ratios as the vehicle moves, freeing the driver from having to shift gears manually.
Chronic venous insufficiency (CVI) is a result of either primary or secondary causes. The most common etiology of secondary CVI is deep venous thrombosis (DVT), which may result in venous obstruction and/or reflux. Nonthrombotic causes of CVI include external compression by adjacent arteries, ligaments, tumors, aneurysm, fibrosis, and cysts. 1-3