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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Muscle disorders are caused by disruption of normal innervation, degeneration and replacement of muscle cells, injury, lack of use or disease. Muscular atrophy refers to a decrease in size of muscles. Individual muscle fibers decrease in size, and there is a progressive loss of myofibrils.