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Answer Wiki. Summary: peak running performance after donating blood may be impacted for up to 1-2 weeks after donating 1 pint of blood, but is most noticeably impacted within the first 1-2 days after donating when attempting to perform at peak levels during endurance activities.
While you may lose a little weight and burn some calories during a donation, giving blood should not be thought of as a weight loss tool. Think of it as a chance to help others in need. You must meet certain eligibility requirements before giving, and it's important to eat well before your donation.