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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
Serotonin and melatonin are both neurotransmitters derived from the essential amino acid tryptophan, found in protein. These brain messengers are important for regulating our sleep cycles and our moods.ryptophan and 5-HTP can be converted into serotonin in the digestive tract but must transported to the brain where it is then synthesized into melatonin. The pineal gland in the brain switches on melatonin synthesis when it detects lower levels of light in the ambient environment.