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Bile acid sequestrants are polymeric compounds that serve as ion-exchange resins. Bile acid sequestrants exchange anions such as chloride ions for bile acids.By doing so, they bind bile acids and sequester them from the enterohepatic circulation. The liver then produces more bile acids to replace those that have been lost.ile acid sequestrants are large polymeric structures, and they are not significantly absorbed from the gut into the bloodstream. Thus, bile acid sequestrants, along with any bile acids bound to the drug, are excreted via the feces after passage through the gastrointestinal tract.
If it does, you have to try cholestyramine or some other bile salt sequestrant. IBS is just a bunch of digestive system problems that haven't been properly diagnosed. My IBS turned out to be bile salt diarrhea. After suffering for years, I went to a specialist who prescribled cholestyramine just on a hunch. It helped a little, so I asked him if I could double the dose. He rewrote the prescription for double the doses and, within one day, I had my life back again.