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Bile acid sequestrants are polymeric compounds that serve as ion-exchange resins. Bile acid sequestrants exchange anions such as chloride ions for bile acids.By doing so, they bind bile acids and sequester them from the enterohepatic circulation. The liver then produces more bile acids to replace those that have been lost.ile acid sequestrants are large polymeric structures, and they are not significantly absorbed from the gut into the bloodstream. Thus, bile acid sequestrants, along with any bile acids bound to the drug, are excreted via the feces after passage through the gastrointestinal tract.
By Mayo Clinic Staff. Bile reflux occurs when bile â a digestive liquid produced in your liver â backs up (refluxes) into your stomach and the tube that connects your mouth and stomach (esophagus). Bile reflux may accompany acid reflux, the medical term for the backwash of stomach acids into your esophagus. However, bile acid reflux and acid reflux are separate conditions. Whether bile is important in reflux is controversial. Bile is often a suspected cause of reflux when people respond incompletely or not at all to powerful acid-suppressant medications. But there is little evidence pinpointing the effects of bile reflux in people. Unlike acid reflux, bile reflux usually can't be completely controlled by changes in diet or lifestyle.