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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Usually, central nervous system disorders and progressive neuromuscular disorders are the main cause of Low Muscle Tone or Hypotonia. Some of the medical conditions that may cause Low Muscle Tone or Hypotonia are: 1  Down syndrome. 2  Muscular Dystrophy. 3  Cerebral palsy. 4  Prader-Willi syndrome. 5  Myotonic dystrophy. 6  Tay-Sachs disease.