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One common cause of muscle aches and pain is fibromyalgia, a condition that causes tenderness in your muscles and surrounding soft tissue, sleep difficulties, fatigue, and headaches.
Inflammation: Generalized inflammation or that associated with inflammatory arthritis (autoimmune) can cause pain and stiffness in the ligaments and tendons around the knee. If there's fluid in the joint, tapping this can be important as are xrays and blood tests.