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Clindamycin does not interact with coumadin directly, though clindamycin is shown to cause liver damage, If this is the case the coumadin can increase INR greater than expected..Regards, kindly click ACCEPT if i have answered to your satisfation, a positive feedback and a bonus will be highly appreciated..esolved Question: my mother take coumadin and was given clindamycin for a tooth infection. Her INR is now 4.8. Her dentist told her that the antibiotic should not interact with her coumadin.
Heparin binds to ATIII, causing a conformational change that activates ATIII and potentiates its action. Back to the tests. Since both Coumadin and heparin affect factors on both sides of the coagulation pathway, giving either Coumadin or heparin should cause the prolongation of both the PT/INR and the PTT. However, the PT/INR is a better test for monitoring patients on Coumadin, and the PTT is a better test for monitoring patients on heparin, for the following reasons.