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One common cause of muscle aches and pain is fibromyalgia, a condition that causes tenderness in your muscles and surrounding soft tissue, sleep difficulties, fatigue, and headaches.
Joint tenderness, sensitivity of the joints to touch, can also occur in people with OA. Pain and tenderness can be caused by: bones rubbing against each other; inflammation in the joints; bone spurs (bony growths) pinched nerves caused by swelling and displacement of joint tissue; Swelling. Swelling is more common in people with RA than OA.