In bacteria, transcription begins with the binding of RNA polymerase to the promoter in DNA. RNA polymerase is a core enzyme consisting of five subunits: 2 Î± subunits, 1 Î² subunit, 1 Î²' subunit, and 1 Ï subunit.
Untreated gout can cause a risk for diabetes and heart disease. Chronic gout can also cause kidney stones. Gout is caused by a buildup of uric acid in the blood. It cristalizes in the joints, with the big toe being the location in half of the cases. This is called podagra.
In this article. Gout is caused by too much uric acid in the bloodstream. Over time, deposits of uric acid crystals collect around bone or cartilage. The build-up of uric acid may cause no symptoms at first. If the area becomes inflamed, a gout attack occurs, with swelling, redness, and intense pain. Acute gout attacks can be treated with over-the-counter anti-inflammatory drugs, such as ibuprofen, or more powerful prescription medicines.