In bacteria, transcription begins with the binding of RNA polymerase to the promoter in DNA. RNA polymerase is a core enzyme consisting of five subunits: 2 Î± subunits, 1 Î² subunit, 1 Î²' subunit, and 1 Ï subunit.
Untreated gout can cause a risk for diabetes and heart disease. Chronic gout can also cause kidney stones. Gout is caused by a buildup of uric acid in the blood. It cristalizes in the joints, with the big toe being the location in half of the cases. This is called podagra.
A heart attack, also called a myocardial infarction, is death of or damage to part of the heart muscle due to an insufficient blood supply. Heart attacks occur when one of the coronary arteries that supply blood to the heart muscle is blocked. Blockage is usually caused from a buildup of plaque (deposits of fat-like substances) due to atherosclerosis. If a plaque deposit tears or ruptures, a blood clot may form and block the artery, causing a heart attack.