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All parts are affected in some manner, since it is a disease that affects the brain. It is a disease of nervous system. So it affects the parts wherever nerves are and nerves are about everywhere in body. Huntington's is a neurological disease that affects the brain.
Huntingtonâs disease is caused by changes (mutations) of a gene that is located on the short arm (p) of chromosome 4 (4p16.3). Chromosomes are found in the nucleus of all body cells. They carry the genetic characteristics of each individual.