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During the digestive period, intestinal phase signals stimulate the release of bile into the small intestine. Fatty acids in the lumen of the duodenum stimulate endocrine cells to release the hormone cholecystokinin (CCK). CCK stimulates contractions in the smooth muscle of the gallbladder. Views.
After a meal, bile is released by the gallbladder when the small intestine secretes a hormone called cholecystokinin. Then the bile flows into the small intestine and helps to break down fats â for example, that big cheeseburger you just ate.