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Overview. Posttransplant lymphoproliferative disease (PTLD) is an unusual entity that has many features of an immune system malignancy. It is characterized by uncontrolled proliferation of lymphoid lineage cells (typically B cells, rarely non-B lineage) in a context of posttransplant immunosuppression.
The most common cancers in people who receive organ transplants are skin cancer and post-transplant lymphoproliferative disorder (PTLD). PTLD behaves like an aggressive lymphoma. Lymphoproliferative disorders are among the most serious complications of long-term immunosuppression for people who have organ transplants.