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Certain medications may also lead to a low white blood cell count because they can destroy white blood cells or damage the bone marrow. For example, taking antibiotics may sometimes cause an abnormal drop in neutrophils, a condition known as neutropenia.
Gram-positive bacteria, with no membrane outside the peptidoclycan cell wall, are more susceptible to these antibiotics. Cell walls without intact peptidoglycan cross-links are structurally weak, and disintegrate when cells divide. This is how penicillins and cephalosporins work to disable bacteria.