In bacteria, transcription begins with the binding of RNA polymerase to the promoter in DNA. RNA polymerase is a core enzyme consisting of five subunits: 2 Î± subunits, 1 Î² subunit, 1 Î²' subunit, and 1 Ï subunit.
Untreated gout can cause a risk for diabetes and heart disease. Chronic gout can also cause kidney stones. Gout is caused by a buildup of uric acid in the blood. It cristalizes in the joints, with the big toe being the location in half of the cases. This is called podagra.
As time goes on, less and less oxygen makes it to the heart, which can cause a heart attack. Coronary artery disease can lead to heart failure and arrhythmias (irregular heart beats). While some people are genetically predisposed to heart disease, it often develops due to poor lifestyle habits.