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All parts are affected in some manner, since it is a disease that affects the brain. It is a disease of nervous system. So it affects the parts wherever nerves are and nerves are about everywhere in body. Huntington's is a neurological disease that affects the brain.
Although the debilitating symptoms of Huntingtonâs disease â which include involuntary movements, severe mood swings and difficulty swallowing â are primarily due to the gradual death of specific nerve cells, this breakdown in the blood-brain barrier most likely contributes to the deterioration of the Huntingtonâs brain.