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Patients with cardiomyopathy, a stiffening and thickening of the heart muscle that weakens it, may develop an enlarged heart as it labors to pump an adequate supply of blood to the body. Coronary artery disease, in which plaque in the arteries interferes with the flow of blood, can cause the heart to enlarge.
In particular, an enlarged heart is a common cause of heart failure. The right and left sides of your heart do different jobs. The right side takes in blood that has travelled round the body and pumps it to the lungs. From here, the blood enters the left side of the heart from where it is pumped all round your body. Because the left side of the heart has to work harder to get blood round your body, it is usually this side that becomes enlarged when your blood pressure is too high. This is sometimes called left ventricular hypertrophy or LVH for short. In other words, it is another name for an enlarged heart.