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Risk factors for bladder cancer. A risk factor is something that increases the risk of developing cancer. It could be a behaviour, substance or condition. Most cancers are the result of many risk factors. Smoking is the most important risk factor for bladder cancer. The risk of developing bladder cancer increases with age. It usually occurs in people older than 65 years of age. Bladder cancer is most common in Caucasians, and men develop this disease more often than women.
Although researchers cannot pinpoint the exact causes of bladder cancer, several risk factors for the disease have been identified. 1  The greatest risk factor for developing bladder cancer is smoking. When you smoke, the carcinogens are absorbed into the lungs and enter the bloodstream.