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Insulin and glucagon are hormones that work to regulate the level of sugar (glucose) in the body to keep it within a healthy range. Unlike the acinar cells, the islets of Langerhans do not have ducts and secrete insulin and glucagon directly into the bloodstream. Depending on what youâve eaten, how much exercise your muscles are doing, and how active your body cells are, the amount of glucose in your bloodstream and cells varies.
These are the Î±-cells and the Î²-cells. The Î±-cells produce glucagon and the Î²-cells produce insulin. The pancreas secretes these antagonistic hormones into the extracellular fluid, which then enters the circulatory system and regulates the concentration of glucose in the blood.For biologists, this is known as a simple endocrine pathway.he blood glucose level declines to the set point and the stimulus for insulin release diminishes as we return to homeostasis. After we skip a meal, our blood glucose level drops because our bodies have used up most of the glucose that was already in the blood from the previous meal.