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Risk factors for bladder cancer. A risk factor is something that increases the risk of developing cancer. It could be a behaviour, substance or condition. Most cancers are the result of many risk factors. Smoking is the most important risk factor for bladder cancer. The risk of developing bladder cancer increases with age. It usually occurs in people older than 65 years of age. Bladder cancer is most common in Caucasians, and men develop this disease more often than women.
1 Blockages in the urinary tract. 2  Kidney stones or an enlarged prostate can trap urine in the bladder and increase the risk of UTIs. 3  A suppressed immune system. 4  Diabetes and other diseases that impair the immune system â the body's defense against germs â can increase the risk of UTIs.