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Certain medications may also lead to a low white blood cell count because they can destroy white blood cells or damage the bone marrow. For example, taking antibiotics may sometimes cause an abnormal drop in neutrophils, a condition known as neutropenia.
As most cases of uncomplicated cellulitis are caused by Strep, they are still best treated with a penicillin or cephalosporin (e.g., Keflex) type of antibiotic, known as beta-lactams. These antibiotics are much better than TMP-SMX for strep infections. These drugs are also safer than clindamycin, for widespread use. Clindamycin and TMP-SMX drugs should be reserved for abscesses or draining wounds with a high likelihood of MRSA, not used for every uncomplicated skin infection.