Amikacin was patented in 1971 and came into commercial use in 1976. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is 13.80 to 130.50 USD for a month.
olfactory. pertaining to smell. olfactory nerve the first cranial nerve; it is purely sensory and is concerned with the sense of smell. The nerve cell bodies are situated in the olfactory area of the mucous membrane of the nose.lfactory system. includes the olfactory part of the nasal mucosa, the olfactory nerves and the olfactory bulbs of the cerebrum. olfactory tract. a band of white nerve fibers visible on the ventral surface of the brain running caudally from the olfactory bulbs.
Olfactory receptors expressed in the cell membranes of olfactory receptor neurons are responsible for the detection of odor molecules.Activated olfactory receptors are the initial player in a signal transduction cascade which ultimately produces a nerve impulse which is transmitted to the brain.xpression [edit]. In vertebrates, the olfactory receptors are located in both the cilia and synapses of the olfactory sensory neurons and in the epithelium of the human airway. In insects, olfactory receptors are located on the antennae and other chemosensory organs.