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Anaphylactic reactions are excluded by the presence of red plasma or urine, discordant pretransfusion and posttransfusion ABO blood types, or a positive direct antiglobulin (Coombs) test result. Demonstration of anti-IgA in a pretransfusion sample of the recipient's serum or plasma establishes the diagnosis.
It is performed by collecting a urine sample from the patient in a specimen cup. Usually only small amounts (30-60 ml's) may be required for urinalysis testing. The sample can be either analyzed in the medical clinic or sent to a laboratory to perform the tests.