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There are several different types of globin chains, named alpha, beta, delta, and gamma. Normal hemoglobin types include: 1  Hemoglobin A (Hb A): makes up about 95%-98% of hemoglobin found in adults; it contains two alpha (Î±) chains and two beta (Î²) protein chains.
The globin genes encode the globin chains that make up hemoglobin (Hb). More than 1000 polymorphic variants of the globin genes have been characterized, consisting of single nucleotide substitutions through to complex gene rearrangements.