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Patients with cardiomyopathy, a stiffening and thickening of the heart muscle that weakens it, may develop an enlarged heart as it labors to pump an adequate supply of blood to the body. Coronary artery disease, in which plaque in the arteries interferes with the flow of blood, can cause the heart to enlarge.
Heart Failure Due To An Enlarged Heart. If the left ventricle is the area affected, the heart can weaken to the point that it cannot meet the body's demand for blood. This can lead to heart failure. An enlarged heart can also disrupt the heart's rhythm, resulting in cardiac arrest. Patients with an enlarged heart are also at greater risk of developing blood clots inside the heart that are attached to the heart's lining.