In bacteria, transcription begins with the binding of RNA polymerase to the promoter in DNA. RNA polymerase is a core enzyme consisting of five subunits: 2 Î± subunits, 1 Î² subunit, 1 Î²' subunit, and 1 Ï subunit.
Untreated gout can cause a risk for diabetes and heart disease. Chronic gout can also cause kidney stones. Gout is caused by a buildup of uric acid in the blood. It cristalizes in the joints, with the big toe being the location in half of the cases. This is called podagra.
Heart attacks (myocardial infarctions) are usually caused by blockage of the arteries that supply the heart muscle with blood. A weakened heart muscle does not cause heart attacks. It should be noted that many people with CHF also have blocked arteries, and indeed heart attacks can cause CHF.