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Some people will suffer a mild form of an allergic reaction and have minor symptoms including such things as hives. Those with a more serious reaction to onions may even have problems just breathing in the smell of onions without having an allergic reaction that can compromise their health.
A study done with people with gastroesophageal reflux disease, or GERD, showed that onions can affect the pressure within your stomach, which forces the sphincter to open, allowing your last meal along with the acidity of your stomach to come back up and burn your sensitive esophagus at the same time.