In bacteria, transcription begins with the binding of RNA polymerase to the promoter in DNA. RNA polymerase is a core enzyme consisting of five subunits: 2 Î± subunits, 1 Î² subunit, 1 Î²' subunit, and 1 Ï subunit.
Untreated gout can cause a risk for diabetes and heart disease. Chronic gout can also cause kidney stones. Gout is caused by a buildup of uric acid in the blood. It cristalizes in the joints, with the big toe being the location in half of the cases. This is called podagra.
Gout attacks occur when you have hyperuricemia, a condition where you have high levels of uric acid in your blood. Normally, uric acid dissolves in your blood and passes through your kidneys without causing any harm. However, your body may either create too much uric acid or fail to excrete enough of it in your urine.