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Anaphylactic reactions are excluded by the presence of red plasma or urine, discordant pretransfusion and posttransfusion ABO blood types, or a positive direct antiglobulin (Coombs) test result. Demonstration of anti-IgA in a pretransfusion sample of the recipient's serum or plasma establishes the diagnosis.
Because Xenomics' Tr-DNA test uses urine specimens instead of blood, as required for most existing tests, it is significantly safer and easier to collect; blood is potentially infectious and is widely considered to be a biological hazard to health care workers, whereas, urine is not.