1 The medicine may be given every six to eight hours, as needed, up to 40 mg per kg per day. 2  Infants younger than 6 months of ageâUse and dose must be determined by your doctor. 3  For menstrual cramps: 4  Adultsâ400 milligrams (mg) every four hours, as needed.
Diclofenac and misoprostol combination is used to relieve symptoms of arthritis (eg, osteoarthritis or rheumatoid arthritis) in patients who may develop stomach ulcers from taking nonsteroidal anti-inflammatory drugs (NSAIDs).
Diclofenac/misoprostol contains a nonsteroidal anti-inflammatory drug (NSAID). It may cause an increased risk of serious, and sometimes fatal, heart and blood vessel problems (eg, a heart attack, stroke). The risk may be greater if you already have heart problems or if you take diclofenac/misoprostol for a long time. Do not use diclofenac/misoprostol right before or after bypass heart surgery. Diclofenac/misoprostol may cause an increased risk of serious and sometimes fatal stomach ulcers and bleeding.