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Atherosclerosis is a disease in which plaque builds up inside your arteries. Arteries are blood vessels that carry oxygen-rich blood to your heart and other parts of your body. Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood. Over time, plaque hardens and narrows your arteries.This limits the flow of oxygen-rich blood to your organs and other parts of your body. Atherosclerosis can lead to serious problems, including heart attack, stroke, or even death.oronary Heart Disease. Coronary heart disease (CHD), also called coronary artery disease, occurs when plaque builds up in the coronary arteries. These arteries supply oxygen-rich blood to your heart. Plaque narrows the coronary arteries and reduces blood flow to your heart muscle.
Plaque is made up of cholesterol, calcium, and fibrous tissue. This stiffening process is called atherosclerosis, or hardening of the arteries. When enough plaque builds and interferes with blood flow, it is called aortoiliac occlusive disease. Reduced blood flow to the legs can lead to a condition called ischemia.