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During the digestive period, intestinal phase signals stimulate the release of bile into the small intestine. Fatty acids in the lumen of the duodenum stimulate endocrine cells to release the hormone cholecystokinin (CCK). CCK stimulates contractions in the smooth muscle of the gallbladder. Views.
The gallbladder stores bile that is produced in the liver. When fats enter the duodenum, the duodenum secretes the hormone cholecystokinin (CCK) into the blood stream which stimulates the contraction of the gall bladder and the opening of the hepatopancreatic ampulla of Vater.