In bacteria, transcription begins with the binding of RNA polymerase to the promoter in DNA. RNA polymerase is a core enzyme consisting of five subunits: 2 Î± subunits, 1 Î² subunit, 1 Î²' subunit, and 1 Ï subunit.
Untreated gout can cause a risk for diabetes and heart disease. Chronic gout can also cause kidney stones. Gout is caused by a buildup of uric acid in the blood. It cristalizes in the joints, with the big toe being the location in half of the cases. This is called podagra.
Gout may be an early warning sign of life-threatening heart disease, new research shows. Dutch researchers found middle-aged patients with the painful joint condition were more likely to have high blood pressure, raised cholesterol levels and diabetes. They said GPs should examine patients with gout to see if they have signs of cardiovascular disease. The study does not suggest gout causes heart attacks. But it does show it could be a marker for the disease in patients with no previous history of cardiac trouble.