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South Carolina Beaufort County Bluffton. Bluffton is located in Beaufort County. It is Hilton Head Island's closest mainland neighbor. In the early 1800s rice and cotton planters from the Low Country built summer houses on this High Bluff overlooking the May River.
HISTORICAL PROFILE OF HAMPTON COUNTY. 1  Depiction of profile as reported by Martha Bee Anderson. A spirit of independence created South Carolina's 33rd county.By act of the South Carolina General Assembly February 18, 1878, the northern portion of Beaufort County was cut away to form Hampton County, South Carolina.