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During the digestive period, intestinal phase signals stimulate the release of bile into the small intestine. Fatty acids in the lumen of the duodenum stimulate endocrine cells to release the hormone cholecystokinin (CCK). CCK stimulates contractions in the smooth muscle of the gallbladder. Views.
Both are released by the duodenum of the small intestine in the presence of a meal (particularly one containing fats) â secretin signals the liver to increase its bile flow out into the intestine while CCK signals the gallbladder to contract and release stored bile.