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Patients with cardiomyopathy, a stiffening and thickening of the heart muscle that weakens it, may develop an enlarged heart as it labors to pump an adequate supply of blood to the body. Coronary artery disease, in which plaque in the arteries interferes with the flow of blood, can cause the heart to enlarge.
There are many diseases that can cause an enlarged heart. These include heart valve or heart muscle disease, arrhythmia, weakening of the heart muscle, fluid around your heart, high blood pressure, and pulmonary hypertension. You can also develop an enlarged heart after thyroid disease or chronic anemia.