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There are several different types of globin chains, named alpha, beta, delta, and gamma. Normal hemoglobin types include: 1  Hemoglobin A (Hb A): makes up about 95%-98% of hemoglobin found in adults; it contains two alpha (Î±) chains and two beta (Î²) protein chains.
Hemoglobin is made of two proteins: Alpha globin and beta globin. Thalassemia occurs when there is a defect in a gene that helps control production of one of these proteins. Alpha thalassemia occurs when a gene or genes related to the alpha globin protein are missing or changed (mutated).