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Patients with cardiomyopathy, a stiffening and thickening of the heart muscle that weakens it, may develop an enlarged heart as it labors to pump an adequate supply of blood to the body. Coronary artery disease, in which plaque in the arteries interferes with the flow of blood, can cause the heart to enlarge.
The answer: Itâs known as cardiomegaly, and itâs often a sign of an underlying problem. âAn enlarged heart is a general term that refers to the pumping chamber of your heart,â said Dr. Nieca Goldberg, medical director of the Joan H. Tisch Center for Womenâs Health. âThere are several conditions that can cause an enlarged heart and those include untreated high blood pressure, diabetes and obesity.â.