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An enlarged heart is medically known as cardiomegaly. Cardiomegaly can be caused by a number of different conditions, including diseases of the heart muscle or heart valves, high blood pressure, arrhythmias, and pulmonary hypertension. Cardiomegaly can also sometimes accompany longstanding anemia and thyroid diseases, among other conditions. Infiltrative diseases of the heart, for example, in which abnormal proteins (amyloidosis) or excess iron (hemochromatosis) accumulate within the tissues of the heart, can also cause an enlargement of the heart.
Heart Failure Due To An Enlarged Heart. If the left ventricle is the area affected, the heart can weaken to the point that it cannot meet the body's demand for blood. This can lead to heart failure. An enlarged heart can also disrupt the heart's rhythm, resulting in cardiac arrest. Patients with an enlarged heart are also at greater risk of developing blood clots inside the heart that are attached to the heart's lining.