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Patients with cardiomyopathy, a stiffening and thickening of the heart muscle that weakens it, may develop an enlarged heart as it labors to pump an adequate supply of blood to the body. Coronary artery disease, in which plaque in the arteries interferes with the flow of blood, can cause the heart to enlarge.
What Is an Enlarged Heart? An enlarged heart is an abnormal increase in size or thickness in the heart muscle, often causing the heart to pump blood inefficiently. Although an enlarged heart is not an actual illness, it is a symptom of many heart- or blood-related illnesses.