In bacteria, transcription begins with the binding of RNA polymerase to the promoter in DNA. RNA polymerase is a core enzyme consisting of five subunits: 2 Î± subunits, 1 Î² subunit, 1 Î²' subunit, and 1 Ï subunit.
Untreated gout can cause a risk for diabetes and heart disease. Chronic gout can also cause kidney stones. Gout is caused by a buildup of uric acid in the blood. It cristalizes in the joints, with the big toe being the location in half of the cases. This is called podagra.
âHigh-purine foods can set off a gout attack, but they are not the underlying cause,â says Theodore Fields, MD, spokesperson for GoutPitStop.com, director of the Rheumatology Faculty Practice Plan at the Hospital for Special Surgery, and professor of clinical medicine at Weill Cornell Medical College in New York City.