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All parts are affected in some manner, since it is a disease that affects the brain. It is a disease of nervous system. So it affects the parts wherever nerves are and nerves are about everywhere in body. Huntington's is a neurological disease that affects the brain.
How does Huntington's disease affect a person? HD is a genetically transmitted disease. The body is unable to process an amino acid, which results in changes occurring over time in the structure of the brain.