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Insulin and glucagon are hormones that work to regulate the level of sugar (glucose) in the body to keep it within a healthy range. Unlike the acinar cells, the islets of Langerhans do not have ducts and secrete insulin and glucagon directly into the bloodstream. Depending on what youâve eaten, how much exercise your muscles are doing, and how active your body cells are, the amount of glucose in your bloodstream and cells varies.
The inability of the islet cells to make insulin or the failure to produce amounts sufficient to control blood glucose level are the causes of diabetes mellitus. The alpha cells of the islets of Langerhans produce an opposing hormone, glucagon, which releases glucose from the liver and fatty acids from fat tissue. In turn, glucose and free fatty acids favour insulin release and inhibit glucagon release.