In bacteria, transcription begins with the binding of RNA polymerase to the promoter in DNA. RNA polymerase is a core enzyme consisting of five subunits: 2 Î± subunits, 1 Î² subunit, 1 Î²' subunit, and 1 Ï subunit.
Untreated gout can cause a risk for diabetes and heart disease. Chronic gout can also cause kidney stones. Gout is caused by a buildup of uric acid in the blood. It cristalizes in the joints, with the big toe being the location in half of the cases. This is called podagra.
He may also have high blood pressure and diabetes. The gout attack will wake him up in the middle of the night with severe pain in the joint of a big toe. Of course, not all gout attacks play out this way. Women get gout, too, especially after menopause, and gout can also attack in other places.