1 The medicine may be given every six to eight hours, as needed, up to 40 mg per kg per day. 2  Infants younger than 6 months of ageâUse and dose must be determined by your doctor. 3  For menstrual cramps: 4  Adultsâ400 milligrams (mg) every four hours, as needed.
diclofenac-misoprostol oral is used to treat the following: 1  Rheumatoid Arthritis and High Risk of Developing Gastric Ulcers, Osteoarthritis and High Risk of Developing Gastric Ulcers. 2  Gout, Ankylosing Spondylitis and High Risk of Developing Gastric Ulcers, Non-Radiographic Axial Spondyloarthritis.
Diclofenac/misoprostol contains a nonsteroidal anti-inflammatory drug (NSAID). It may cause an increased risk of serious, and sometimes fatal, heart and blood vessel problems (eg, a heart attack, stroke). The risk may be greater if you already have heart problems or if you take diclofenac/misoprostol for a long time. Do not use diclofenac/misoprostol right before or after bypass heart surgery. Diclofenac/misoprostol may cause an increased risk of serious and sometimes fatal stomach ulcers and bleeding.