In bacteria, transcription begins with the binding of RNA polymerase to the promoter in DNA. RNA polymerase is a core enzyme consisting of five subunits: 2 Î± subunits, 1 Î² subunit, 1 Î²' subunit, and 1 Ï subunit.
Untreated gout can cause a risk for diabetes and heart disease. Chronic gout can also cause kidney stones. Gout is caused by a buildup of uric acid in the blood. It cristalizes in the joints, with the big toe being the location in half of the cases. This is called podagra.
Factors that can precipitate a gout attack, include: 1  Overweight â many patients who suffer from gout are overweight or obese. 2  Alcohol â acute attacks of gout are often precipitated by overindulgence in alcohol. 3  Dietary purines â eating foods rich in purines (meat, fish, fish roes) can cause an attack.