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Abstract. A nonsense mutation occurs when a sense codon, one that codes for an amino acid, is changed to one of the chainâtermination codons, UAG, UAA or UGA. A nonsense suppressor can result from a second mutation affecting the translational apparatus. This mutation enables the cell to insert an amino acid in response to the nonsense codon, resulting in a wildâtype or near wildâtype phenotype. Some suppressor mutations change the anticodon of a transfer ribonucleic acid (tRNA) such that it can pair with the nonsense codon.
Silent mutation. Definition. noun, plural: silent mutations. A form of point mutation resulting in a codon that codes for the same or a different amino acid but without any functional change in the protein product. Supplement. Silent mutations do not cause changes in the amino acid sequence and hence the protein is still functional.