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Pesticide resistance is the ability of a pest population, such as insects, fungi, weeds or rodents, to evolve a tolerance to a pesticide that it was previously susceptible to. Retrieved from http://en.wikipedia.org/wiki/Pesticide_...
Insect resistance is one of the biggest concerns with Bt. Up till now, resistance in the field have been very rare. But laboratory studies have shown that insects are capable of developing resistance. It is only a matter of time when insects in the field develop resistance to Bt.