Holden /hold-en/ [2 sylls.] as a boys' name is pronounced HOHL-den. It is of Old English origin, and the meaning of Holden is deep valley. The hero of JD Salinger's novel The Catcher in the Rye is named Holden Caulfield.ariations. Holden is an uncommon given name for males but a very popular last name for both adults and children (#940 out of 150436, Top 1%).
Delta-9-tetrahydrocannabinol (Î´9-THC, THC) and delta-8-tetrahydrocannabinol (Î´8-THC), mimic the actions of anandamide and 2-arachidonoylglycerol, neurotransmitters produced naturally in the body. These cannabinoids produce the effects associated with cannabis by binding to the CB1 cannabinoid receptors in the brain.
The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors. The anxiolytic effect of CBD on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system. Plant-based medicines for anxiety disorders, part 2. A systematic review of plant-derived natural compounds for anxiety disorders. The Endocannabinoid System and Anxiety.