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A histiocytoma is a benign skin tumor that originates in the Langerhans cells, immune cells that function to provide protective immunity to the tissues that are in contact with the outer environment -- the nose, stomach, intestines and lungs, but mainly the skin's surface. histiocytoma is a benign skin tumor that originates in the Langerhans cells, immune cells that function to provide protective immunity to the tissues that are in contact with the outer environment -- the nose, stomach, intestines and lungs, but mainly the skin's surface.
Malignant fibrous histiocytoma is the most common mesenchymal malignancy and accounts for approximately 24% of all soft-tissue sarcomas (3), with about 7%â10% of occurrences being confined to the subcutis, and there is typically no fascial involvement (4,5).