Organic acids are ubiquitous throughout the field of chemistry. Whether used as a solvent, a substrate, a strong acid, or in a catalytic amount as a Bronsted acid source, organic acids are as commonplace as glassware for the researcher.
where p is the frequency of the A allele and q is the frequency of the a allele in the population. In the equation, p 2 represents the frequency of the homozygous genotype AA, q 2 represents the frequency of the homozygous genotype aa, and 2pq represents the frequency of the heterozygous genotype Aa.
Thus, this entire population consists of 12,258 (6129 X 2) alleles at the blood type locus. To deter mine the allelic frequencies we simply count the number of M or N alleles and divide by the total number of alleles. So the allelic frequency for the M allele will be:f(M) = [(2 x 1787) + 3039]/12,258 = 0.5395 and the frequency for the N allele will be: f(N) = [(2 x 1303) + 3039]/12,258 = 0.4605 By convention one of the alleles is given the designation P and the other q. Thus for the data we presented above, p=0.5395 and q=0.4605.Because we are analyzing all the alleles, the frequencies shoul d sum to 1.0 and p + q = 1.Furthermore, a population is considered by population geneticists to be polymorphic if two alleles are segregating and if the frequency of the most frequent allele is less than 0.99.y convention one of the alleles is given the designation P and the other q. Thus for the data we presented above, p=0.5395 and q=0.4605. Because we are analyzing all the alleles, the frequencies shoul d sum to 1.0 and p + q = 1.