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(3) renal â glutamine break down in proximal tubule (combines with H+ -> NH4+ and eliminated) CAUSES OF HYPERAMMONAEMIA. Overproduction of ammonia. Protein/ amino acid load. gastrointestinal hemorrhage. gastric bypass. multiple myeloma. allogeneic stem cell transplantation.
Limited animal data has shown that osteoporosis secondary to chronic metabolic. acidosis may occur. Inhalation of ammonia causes rapid onset of signs and its toxic effects are mediated through. its irritant and corrosive properties. Features include irritation to the nose, throat and. respiratory tract. Increased lacrimation, coughing, an increased respiratory rate as well as. respiratory distress may occur.