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Symptoms of Bernard-Soulier Syndrome. The list of signs and symptoms mentioned in various sources for Bernard-Soulier Syndrome includes the 12 symptoms listed below: Excessive bleeding following injury. Frequent nosebleeds. Heavy menstrual flow. Easy bruising. Slow-healing bruises. Skin hemorrhage. Sbucutaneous bleeding.
A Dr. Michael T. Murray, ND , Naturopathic Medicine, answered. A deficiency of thiamine (vitamin B1) usually results in fatigue, depression, pins and needles sensations or numbness in the legs, and constipation. Severe thiamine deficiency results in a deficiency syndrome known as beriberi. Symptoms include mental confusion, muscle wasting (dry beriberi), fluid retention (wet beriberi), high blood pressure, difficulty walking, and heart disturbances.