Causes. Acute liver failure is most often caused by infectious agents or toxins, poor flow of fluids into the liver and surrounding tissues (perfusion), hypoxia (inability to breathe), drugs or chemicals that are destructive to the liver (hepatotoxic), and excess exposure to heat.
Definition of operate for English Language Learners. : 1  to function or behave in a proper or particular way. : 2  to use and control (something) : 3  to have control of (something, such as a business, department, program, etc.)
Operationalize means to define the target behaviors in ways that they are clearly defined and measurable. You want the classroom aide, the general education teacher and the principal all to be able to recognize the behavior. You want each of them to be able to conduct part of the direct observation. Examples: 1  General definition: Johnny doesn't stay in his seat. 2  Operational definition: Johnny leaves his seat for 5 or more seconds during instruction. 3  General definition: Lucy throws a tantrum.