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Symptoms of Bernard-Soulier Syndrome. The list of signs and symptoms mentioned in various sources for Bernard-Soulier Syndrome includes the 12 symptoms listed below: Excessive bleeding following injury. Frequent nosebleeds. Heavy menstrual flow. Easy bruising. Slow-healing bruises. Skin hemorrhage. Sbucutaneous bleeding.
Giant platelet syndrome (Bernard-Soulier syndrome): This condition is a primary problem of platelets in which the platelets lack the ability to stick adequately to injured blood vessel walls and as a result of this problem there is abnormal bleeding.he abnormal platelets in the Bernard-Soulier syndrome are usually considerably larger than normal platelets when viewed on blood films or sized by automated instruments. However, this is not the only syndrome with large platelets.