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(3) renal â glutamine break down in proximal tubule (combines with H+ -> NH4+ and eliminated) CAUSES OF HYPERAMMONAEMIA. Overproduction of ammonia. Protein/ amino acid load. gastrointestinal hemorrhage. gastric bypass. multiple myeloma. allogeneic stem cell transplantation.
Quick Answer. A high blood ammonia level occurs due to the failure of the liver to convert the ammonia in the blood to urea, as stated by WebMD. This may be caused by different conditions, such as severe hepatitis and cirrhosis. This can also be associated with hepatic encephalopathy, an infection that occurs when the liver fails to perform its functions.