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A histiocytoma is a benign skin tumor that originates in the Langerhans cells, immune cells that function to provide protective immunity to the tissues that are in contact with the outer environment -- the nose, stomach, intestines and lungs, but mainly the skin's surface. histiocytoma is a benign skin tumor that originates in the Langerhans cells, immune cells that function to provide protective immunity to the tissues that are in contact with the outer environment -- the nose, stomach, intestines and lungs, but mainly the skin's surface.
If this happens, the treatment could be repeated again if desired or the lesion can be completely excised. Back to Index. A dermatofibroma is a round, brownish to red-purple growth commonly found on the legs. It is also called a histiocytoma. It can occur anywhere, but seems to favor exposed areas. Dermatofibromas feel like hard lumps under the skin. They're like an iceberg in that there is more under the skin than seen on the surface. Often these start out as red, turning later to brown, and sometimes itch.