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Abstract. A nonsense mutation occurs when a sense codon, one that codes for an amino acid, is changed to one of the chainâtermination codons, UAG, UAA or UGA. A nonsense suppressor can result from a second mutation affecting the translational apparatus. This mutation enables the cell to insert an amino acid in response to the nonsense codon, resulting in a wildâtype or near wildâtype phenotype. Some suppressor mutations change the anticodon of a transfer ribonucleic acid (tRNA) such that it can pair with the nonsense codon.
There are three stop codons: UAG, UAA, and UGA. In DNA, the uracil (U) is replaced by thymine (T). If a change in the DNA sequence, or mutation, of a gene occurs that creates a stop codon, this is called a nonsense mutation.A nonstop mutation is a change in the sequence of a stop codon that turns it into a codon that specifies an amino acid. To unlock this lesson you must be a Study.com Member.onsense mutations occur when a codon that is supposed to specify an amino acid is changed to a stop codon instead. This results in a protein that is shorter than normal because it cannot finish adding all the necessary amino acids. These truncated proteins are often not functional.