I second that âwaterâ idea. Prunes are most effective if you eat them, and then drink one cup of water â that usually gives both your body, and the prunes enough water to soften your stools. If that doesnât work, wellâ¦ I really donât know what to say.
Abstract. The most common cystic fibrosis transmembrane conductance regulator (CFTR) mutant in cystic fibrosis patients, Î´F508 CFTR, is retained in the endoplasmic reticulum (ER) and is consequently degraded by the ubiquitin-proteasome pathway known as ER-associated degradation (ERAD).
Cystic fibrosis transmembrane conductance regulator (CFTR) is a membrane protein and chloride channel in vertebrates that is encoded by the CFTR gene.CFTR is an ABC transporter-class ion channel that codes for a protein that conducts chloride and thiocyanate ions across epithelial cell membranes.utations of the CFTR gene affecting chloride ion channel function lead to dysregulation of epithelial fluid transport in the lung, pancreas and other organs, resulting in cystic fibrosis.