PANERAI WATCHES. PANERAI. Founded in 1860, in the midst of the Renaissance in Florence, Italy, Panerai has mastered the arts of creativity, technical craftsmanship, and distinguished design. In the past two centuries, Panerai timepieces have served as crucial precision instruments for the Italian navy.
Regulation of Purine Biosynthesis. The PRPP amidotransferase enzyme exists as an active monomer and an inactive polymer (see Introduction to Metabolism Lecture). IMP, GMP and AMP all inactivate the enzyme causing a shift towards the polymerized inactive form. PRPP causes a shift towards the active monomeric form.
-prodrugs requiring activation through purine salvage pathway. -act by inducing mutations (thiopurines pair with both C and T and by inhibiting de novo purine synthesis) -also effective as anti-inflammatory and immunosuppressive drugs (But: higher potential for therapy-related cancer, therefore less used!)