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From there, blood makes its way to the Vena cava, the largest vein in the body to return to the heart. Portal hypertension describes elevated pressure within the portal system, including the portal vein and the tributary veins that drain into it.
Updated August 01, 2016. Portal hypertension is a condition caused by liver disease. It's a type of high blood pressure (hypertension), but instead of affecting the entire body, it mostly affects the portal veins leading from the intestines to the liver. It's a significant complication of alcoholic hepatitis and liver cirrhosis, and can cause swelling and bleeding.