I second that âwaterâ idea. Prunes are most effective if you eat them, and then drink one cup of water â that usually gives both your body, and the prunes enough water to soften your stools. If that doesnât work, wellâ¦ I really donât know what to say.
Abstract. The most common cystic fibrosis transmembrane conductance regulator (CFTR) mutant in cystic fibrosis patients, Î´F508 CFTR, is retained in the endoplasmic reticulum (ER) and is consequently degraded by the ubiquitin-proteasome pathway known as ER-associated degradation (ERAD).
The changes in epithelial cell function which cause the abnormal cellular secretions in CF are the result of an abnormal cell membrane protein called the cystic fibrosis transmembrane regulator (CFTR). The CFTR abnormality results from a defective gene on human chromosome 7.he changes in epithelial cell function which cause the abnormal cellular secretions in CF are the result of an abnormal cell membrane protein called the cystic fibrosis transmembrane regulator (CFTR). The CFTR abnormality results from a defective gene on human chromosome 7.