I second that âwaterâ idea. Prunes are most effective if you eat them, and then drink one cup of water â that usually gives both your body, and the prunes enough water to soften your stools. If that doesnât work, wellâ¦ I really donât know what to say.
Abstract. The most common cystic fibrosis transmembrane conductance regulator (CFTR) mutant in cystic fibrosis patients, Î´F508 CFTR, is retained in the endoplasmic reticulum (ER) and is consequently degraded by the ubiquitin-proteasome pathway known as ER-associated degradation (ERAD).
The gene that, when defective, causes CF is called the cystic fibrosis transmembrane conductance regulator (CFTR) gene. A defect in this single gene causes all the consequences of CF. There are over 1,600 known defects in the CFTR gene that can cause CF.he glands most affected are those in the pancreas and respiratory system and the sweat glands. Cystic fibrosis is usually recognized in infancy or early childhood, chiefly among Caucasians. The earliest manifestation is meconium ileus, an obstruction of the small bowel by viscid stool.