I second that âwaterâ idea. Prunes are most effective if you eat them, and then drink one cup of water â that usually gives both your body, and the prunes enough water to soften your stools. If that doesnât work, wellâ¦ I really donât know what to say.
Abstract. The most common cystic fibrosis transmembrane conductance regulator (CFTR) mutant in cystic fibrosis patients, Î´F508 CFTR, is retained in the endoplasmic reticulum (ER) and is consequently degraded by the ubiquitin-proteasome pathway known as ER-associated degradation (ERAD).
CFTR, the gene associated with cystic fibrosis, encodes the protein cystic fibrosis transmembrane conductance regulator (also abbreviated CFTR, but not italicized). The gene was identified in 1989 and is found at 7q31.2, the long arm (q) of chromosome 7 at position 31.2.owever, if the CFTR protein has been damaged, as in cystic fibrosis, the chloride ions are not allowed out of the mucus-producing cells. As a result, the mucus thickens and becomes sticky and obstructs the various pathways.