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Pathophysiology. The colonic mucosa is a self-renewing epithelium that is structured is a very tightly regulated balance between cell proliferation at the base of a crypt, maturation as colonocytes, migrate up the crypt, and extrusion of senescent and/or apoptotic cells from the upper crypt into the lumen.
The lamina propria of colonic mucosa normally contains eosinophils, lymphocytes, plasma cells, and a few neutrophils.If the number of such cells is judged to be increased, colonic inflammation is said to be present. However, the number of cells present in normal mucosa has not been clearly established.uantification of colonic lamina propria cells by means of a morphometric point-counting method. Lee E(1), Schiller LR, Fordtran JS. Author information: (1)Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas.