Effects of gamma-aminobutyric acid (GABA) receptor agonists on the neurotoxicity and anticonvulsant activity of barbiturates in mice.Ulloque RA, Chweh AY, Swinyard EA.The effects of gamma-aminobutyric acid (GABA) receptor agonists [4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol THIP]; [progabide and baclofen] on the minimal neurotoxicity and anticonvulsant activity of pentobarbital and phenobarbital in mice were investigated.n contrast, baclofen at toxic doses potentiated the anti-PTZ activity of pentobarbital and phenobarbital. Combinations of progabide and pentobarbital or progabide and phenobarbital interacted additively by the maximal electroshock seizure (MES) test.
Recorded in the spellings of Mac, Mack, and Make, not surprisingly this ancient surname is Scottish, but possibly of English origins. It is believed to derive from theYorkshire surname Macwra, itself claimed to be a development of the Danish-Viking personal name Makr.hat is certain is that the name has been held for many centuries by a Berwickshire family, and early examples of the name recording include John Mak, who witnessed a land charter in Ayton, in the year 1470, and William Make, recorded in Lanark in 1510.
Like many historic places in the Great Lakes region, Mackinac Island's name derives from a Native American language. Native Americans in the Straits of Mackinac region likened the shape of the island to that of a turtle.Therefore, they named it Mitchimakinak (Ojibwe mishi-mikinaak) meaning big turtle.t is located in Lake Huron, at the eastern end of the Straits of Mackinac, between the state's Upper and Lower Peninsulas. The island was home to a Native American settlement before European exploration began in the 17th century.