I second that âwaterâ idea. Prunes are most effective if you eat them, and then drink one cup of water â that usually gives both your body, and the prunes enough water to soften your stools. If that doesnât work, wellâ¦ I really donât know what to say.
Abstract. The most common cystic fibrosis transmembrane conductance regulator (CFTR) mutant in cystic fibrosis patients, Î´F508 CFTR, is retained in the endoplasmic reticulum (ER) and is consequently degraded by the ubiquitin-proteasome pathway known as ER-associated degradation (ERAD).
CFTR is an enormous integral membrane protein with about 1,500 amino acids and a complicated structure that spans the cell membrane multiple times in specialized epithelial cells. These form in the lining of the lungs, kidneys, and other tissues that produce mucous, sweat, tears, saliva, and other bodily secretions.