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A histiocytoma is a benign skin tumor that originates in the Langerhans cells, immune cells that function to provide protective immunity to the tissues that are in contact with the outer environment -- the nose, stomach, intestines and lungs, but mainly the skin's surface. histiocytoma is a benign skin tumor that originates in the Langerhans cells, immune cells that function to provide protective immunity to the tissues that are in contact with the outer environment -- the nose, stomach, intestines and lungs, but mainly the skin's surface.
Malignant fibrous histiocytoma is a condition involving a tumor of the bone or soft tissues. Malignant fibrous histiocytoma is a rare condition in which there is a tumor of the bone or soft tissues.The disease is the most common soft tissue cancer that is diagnosed in older adults, and is often diagnosed in people between the ages of 50 and 70.o one knows the exact cause or causes of malignant fibrous histiocytoma; however, research has shown that people with certain risk factors are more likely than others to develop the condition. A risk factor is anything that increases a person's chances of developing a disease.