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Gene mutation on the X chromosome is most common and also explains why (depending on nationality) some 7% of males, but less than 1% of females exhibit color blindness of some form. Males only have one X chromosome, whereas females have two.
The retinal degeneration 1 mutation (Pde6brd1, phophodiesterase 6B, cGMP, rod receptor, beta polypeptide) is present in a number of common inbred strains of mice, including some of those used to make transgenic mice (B6SJLF1/J, B6CBAF1/J and FVB/NJ).Pde6brd1 is recessive and causes blindness by weaning.he hybrid mice (B6SJLF1/J and B6CBAF1/J) segregate Pde6brd1 contributed by SJL or CBA. Unless a transgene integrates close to Pde6b, both blind and sighted transgenic progeny may be produced when B6SJLF1/J and B6CBAF1/J are used.