Causes. Acute liver failure is most often caused by infectious agents or toxins, poor flow of fluids into the liver and surrounding tissues (perfusion), hypoxia (inability to breathe), drugs or chemicals that are destructive to the liver (hepatotoxic), and excess exposure to heat.
Definition of operate for English Language Learners. : 1  to function or behave in a proper or particular way. : 2  to use and control (something) : 3  to have control of (something, such as a business, department, program, etc.)
Operating authority is the term used by transportation regulatory agencies to describe a grant of legal permission by a federal or state government to engage in for-hire interstate (state-to-state) or intrastate (within a state) transportation by motor vehicle. Essentially, it is a business license.