Holden /hold-en/ [2 sylls.] as a boys' name is pronounced HOHL-den. It is of Old English origin, and the meaning of Holden is deep valley. The hero of JD Salinger's novel The Catcher in the Rye is named Holden Caulfield.ariations. Holden is an uncommon given name for males but a very popular last name for both adults and children (#940 out of 150436, Top 1%).
Delta-9-tetrahydrocannabinol (Î´9-THC, THC) and delta-8-tetrahydrocannabinol (Î´8-THC), mimic the actions of anandamide and 2-arachidonoylglycerol, neurotransmitters produced naturally in the body. These cannabinoids produce the effects associated with cannabis by binding to the CB1 cannabinoid receptors in the brain.
The intoxicating effects of cannabinoids are hypothesized to be mediated by actions on cannabinoid receptors in the origin areas (ventral tegmental area) and terminal areas (nucleus accumbens) of the mesocorticolimbic dopamine system and extended amygdala (central nucleus of the amygdala, bed nucleus of the stria terminalis, and a transition zone in the shell of the nucleus accumbens).