Causes. Acute liver failure is most often caused by infectious agents or toxins, poor flow of fluids into the liver and surrounding tissues (perfusion), hypoxia (inability to breathe), drugs or chemicals that are destructive to the liver (hepatotoxic), and excess exposure to heat.
Definition of operate for English Language Learners. : 1  to function or behave in a proper or particular way. : 2  to use and control (something) : 3  to have control of (something, such as a business, department, program, etc.)
Here are all the possible meanings and translations of the word operation. Princeton's WordNet(4.60 / 5 votes)Rate this definition: operation(noun) the state of being in effect or being operative. that rule is no longer in operation. operation(noun) a business especially one run on a large scale.