I second that âwaterâ idea. Prunes are most effective if you eat them, and then drink one cup of water â that usually gives both your body, and the prunes enough water to soften your stools. If that doesnât work, wellâ¦ I really donât know what to say.
Abstract. The most common cystic fibrosis transmembrane conductance regulator (CFTR) mutant in cystic fibrosis patients, Î´F508 CFTR, is retained in the endoplasmic reticulum (ER) and is consequently degraded by the ubiquitin-proteasome pathway known as ER-associated degradation (ERAD).
A defect in the CFTR gene causes cystic fibrosis (CF). This gene makes a protein that controls the movement of salt and water in and out of your body's cells.In people who have CF, the gene makes a protein that doesn't work well.his causes thick, sticky mucus and very salty sweat. Research suggests that the CFTR protein also affects the body in other ways. This may help explain other symptoms and complications of CF. More than a thousand known defects can affect the CFTR gene.