I second that âwaterâ idea. Prunes are most effective if you eat them, and then drink one cup of water â that usually gives both your body, and the prunes enough water to soften your stools. If that doesnât work, wellâ¦ I really donât know what to say.
Abstract. The most common cystic fibrosis transmembrane conductance regulator (CFTR) mutant in cystic fibrosis patients, Î´F508 CFTR, is retained in the endoplasmic reticulum (ER) and is consequently degraded by the ubiquitin-proteasome pathway known as ER-associated degradation (ERAD).
The paper, entitled: The dual phosphodiesterase 3 and 4 inhibitor RPL554 stimulates CFTR and ciliary beating in primary cultures of bronchial epithelia was published on-line in the peer reviewed Journal American Journal of Physiology - Lung Cellular and Molecular Physiology on 6 November 2015.