DXM is also used recreationally. When exceeding label-specified maximum dosages, dextromethorphan acts as a dissociative anesthetic. Its mechanism of action is via multiple effects, including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist.
Aroldis Chapman has thrown the fastest pitch ever recorded, but he has challengers for baseball's hottest heater in 2017. Ever since Aroldis Chapman delivered a 105 mph fastball to Tony Gwynn Jr., Chapman's name has been synonymous with velocity.
Fans, researchers, historians and even the players argue all the time about who was the fastest pitcher of all-time. The most widely quoted response is Nolan Ryan, whose fastball was officially clocked by the Guinness Book of World Records at 100.9 miles per hour in a game played on August 20, 1974, versus the Detroit Tigers. A record that's still included in the book.