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(3) renal â glutamine break down in proximal tubule (combines with H+ -> NH4+ and eliminated) CAUSES OF HYPERAMMONAEMIA. Overproduction of ammonia. Protein/ amino acid load. gastrointestinal hemorrhage. gastric bypass. multiple myeloma. allogeneic stem cell transplantation.
When amino acids are burned as a fuel, ammonia (NH3] is the waste product. Ammonia must be carried to the liver, converted to urea and excreted by the kidneys. One of the penalties of amino acid excess is ammonia excess, a potential cause of body malfunction following a high protein meal. The blood measurement of urea nitrogen (BUN) shows the balance between urea production by the liver and excretion by the kidneys. The BUN rises in kidney failure and serves as a measure of ammonia or nitrogen. In liver disease, reduced ability to synthesize urea leads to ammonia accumulation.