I second that âwaterâ idea. Prunes are most effective if you eat them, and then drink one cup of water â that usually gives both your body, and the prunes enough water to soften your stools. If that doesnât work, wellâ¦ I really donât know what to say.
Abstract. The most common cystic fibrosis transmembrane conductance regulator (CFTR) mutant in cystic fibrosis patients, Î´F508 CFTR, is retained in the endoplasmic reticulum (ER) and is consequently degraded by the ubiquitin-proteasome pathway known as ER-associated degradation (ERAD).
Cystic fibrosis occurs because of mutations in the gene that makes a protein called CFTR (cystic fibrosis transmembrane regulator). A person with CF produces abnormal CFTR protein-or no CFTR protein at all, which causes the body to make thick, sticky mucus instead of the thin, watery kind.umans have 23 pairs of chromosomes in their DNA. The CF gene is found on chromosome number 7. It takes two copies of a CF gene-one inherited from each parent-for a child to show symptoms of CF. Persons born with only one CF gene (inherited from only one parent) and one normal gene are CF carriers.