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Pathophysiology. The colonic mucosa is a self-renewing epithelium that is structured is a very tightly regulated balance between cell proliferation at the base of a crypt, maturation as colonocytes, migrate up the crypt, and extrusion of senescent and/or apoptotic cells from the upper crypt into the lumen.
A colonoscopy is an examination of the lower part of the gastrointestinal tract, which is called the colon or large intestine (bowel). Colonoscopy is performed by an Gastroenterologist, who is a physician with special training in endoscopy/colonoscopy procedures. The colonoscope is inserted into the anus and advanced through the entire colon (to the cecum where the appendix is) and possibly a short distance into the small intestine.