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Dark urine. Glimepiride can cause low blood sugar (hypoglycemia) in some people. This is more common in elderly people and in people with adrenal, pituitary, liver, or kidney problems, as well as during fasting before surgery and after prolonged exercise.
Glimepiride Dosage for Type 2 Diabetes. 1  The recommended starting does is glimepiride 1 mg or glimepiride 2 mg once a day. 2  The recommended starting dose for elderly people and people with kidney, liver, adrenal, or pituitary problems is glimepiride 1 mg daily.  Glimepiride can be used in combination with insulin.