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Homocystinuria (HCU) is an inherited disorder of amino acid metabolism, caused by an enzymatic defect in a metabolic pathway that leads to increased levels of methionine.
Metabolic disorders involving an inability to break down specific amino acids (components of protein). Homocystinuria. The term âhomocystinuriaâ designates a biochemical abnormality, not a specific disease entity. There are many causes of homocystinuria.