When multiserver administration is implemented, target servers periodically contact the master server to upload information on jobs that have been executed, and download new jobs. The process of contacting the master server is called server polling, which takes place at regular polling intervals. Polling Intervals. The polling interval (one minute by default) controls how frequently the target server connects to the master server to download instructions and upload the results of job execution.
In all cases of idiopathic or secondary adult TTP, plasma exchange is the basic treatment of choice. Plasma exchange involves the use of automated machinery which permits the removal of the patient's plasma and replacement with donor plasma during a 3 to 4 hour treatment.
1. Tetrodotoxin (TTX) is a guanidinium compound produced by bacteria in puffer fish and certain other animals such as octopus and chaetognatha. Due to its potent inhibitory effect on several isoforms of voltage-gated Na + (Na V) channels, TTX has been extensively studied in biological and chemical sciences [1] .1B) in TTX block of Na V channels [5] and [8] . Thus, the guanidine group of TTX may interact with the outer charged ring more intimately, rather than protruding into the filter. Here the inhibition of Na V Ab and Na V 1.4 by TTX is examined in atomic detail using molecular dynamics (MD) simulations.