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A histiocytoma is a benign skin tumor that originates in the Langerhans cells, immune cells that function to provide protective immunity to the tissues that are in contact with the outer environment -- the nose, stomach, intestines and lungs, but mainly the skin's surface. histiocytoma is a benign skin tumor that originates in the Langerhans cells, immune cells that function to provide protective immunity to the tissues that are in contact with the outer environment -- the nose, stomach, intestines and lungs, but mainly the skin's surface.
Langerhans cell histiocytosis is a disorder in which excess immune system cells called Langerhans cells build up in the body. Langerhans cells, which help regulate the immune system, are normally found throughout the body, especially in the skin, lymph nodes, spleen, lungs, liver, and bone marrow.