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Pathophysiology. The colonic mucosa is a self-renewing epithelium that is structured is a very tightly regulated balance between cell proliferation at the base of a crypt, maturation as colonocytes, migrate up the crypt, and extrusion of senescent and/or apoptotic cells from the upper crypt into the lumen.
The transverse colon is the longest and most movable part of the colon. It crosses the abdomen from the ascending colon at the hepatic or right colic flexure with a downward convexity to the descending colon where it curves sharply on itself beneath the lower end of the spleen forming the splenic or left colic flexure.