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Pathophysiology. The colonic mucosa is a self-renewing epithelium that is structured is a very tightly regulated balance between cell proliferation at the base of a crypt, maturation as colonocytes, migrate up the crypt, and extrusion of senescent and/or apoptotic cells from the upper crypt into the lumen.
The colonic mucosa was endoscopically normal in all cases. In the terminal ileum, each case had one to several discrete, focal erosions within otherwise normal small bowel mucosa. The erosions were located 1 to 3 cm proximal to the ileocecal valve haustral contraction ring.None were located marginally or on a prominent mucosal fold.he colonic mucosa was endoscopically normal in all cases. In the terminal ileum, each case had one to several discrete, focal erosions within otherwise normal small bowel mucosa. The erosions were located 1 to 3 cm proximal to the ileocecal valve haustral contraction ring.