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This cannot rigorously be described as sigma-pi conjugation since sigma and pi here refer to different defining planes, and interaction between orbitals of different symmetries (with respect to the same defining plane) is forbidden.
pi. n. One class of psychotropic drugs usually prescribed for the treatment of depression. Although the exact mechanisms of action remain unclear, antidepressants primarily work by altering levels of various neurotransmitters (for example, serotonin) available at receptor sites in the brain.t least four distinct classes are in current clinical use: ssris (selective serotonin-reuptake inhibitors), mixed-function (or dual-action agents), tricyclic acids (TCAs), and monoamine oxidase inhibitors (MAOIs).