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Symptoms of Bernard-Soulier Syndrome. The list of signs and symptoms mentioned in various sources for Bernard-Soulier Syndrome includes the 12 symptoms listed below: Excessive bleeding following injury. Frequent nosebleeds. Heavy menstrual flow. Easy bruising. Slow-healing bruises. Skin hemorrhage. Sbucutaneous bleeding.
Practice Essentials. Bernard-Soulier syndrome (BSS) is one of a group of hereditary platelet disorders characterized by thrombocytopenia, giant platelets, and qualitative platelet defects resulting in bleeding tendency.See the image below. Peripheral smear of patient with Bernard-Soulier syndrome (BSS) showing giant platelets.