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A histiocytoma is a benign skin tumor that originates in the Langerhans cells, immune cells that function to provide protective immunity to the tissues that are in contact with the outer environment -- the nose, stomach, intestines and lungs, but mainly the skin's surface. histiocytoma is a benign skin tumor that originates in the Langerhans cells, immune cells that function to provide protective immunity to the tissues that are in contact with the outer environment -- the nose, stomach, intestines and lungs, but mainly the skin's surface.
As readers of the Dermatology Diary learned in the entry for week 3, a histiocytoma is a benign skin tumor, usually seen in young dogs, that often spontaneously regresses without treatment..his is often alarming to dog owners; as it they often appear suddenly, almost overnight. Histiocytomas are not painful, and most dogs do not even seem to notice them, despite the fact that they lump may be ulcerated. Click here to view photos of a histiocytoma in a young dog.