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Pathophysiology. The colonic mucosa is a self-renewing epithelium that is structured is a very tightly regulated balance between cell proliferation at the base of a crypt, maturation as colonocytes, migrate up the crypt, and extrusion of senescent and/or apoptotic cells from the upper crypt into the lumen.
Colonic irrigation or colon hydrotherapy, also known as a colonic, is an alternative medicine practice that involves flushing the colon with warm filtered water. This is thought to remove a buildup of waste, which supporters of the practice believe is harmful for digestive and general health.