1 Address risk factors that can lead to coronary heart disease and other heart problems. 2  These risk factors include high blood pressure, high blood cholesterol, overweight or obesity, diabetes, smoking, lack of physical activity, and depression and other emotional health concerns. 3  Adopt healthy lifestyle changes.
Primary sclerosing cholangitis is often diagnosed before symptoms appear when a routine blood test or an X-ray taken for an unrelated condition shows liver abnormalities. Early symptoms often include: 1  Fatigue. 2  Itching.
The disease is called primary biliary cholangitis (PBC) because the immune system attacks the bile ducts inside the liver, which damages them. When immune cells surround and attack parts of the body, this is called inflammation. Inflammation of the bile ducts is called cholangitis.