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From there, blood makes its way to the Vena cava, the largest vein in the body to return to the heart. Portal hypertension describes elevated pressure within the portal system, including the portal vein and the tributary veins that drain into it.
Portal hypertension. Portal hypertension is hypertension (high blood pressure) in the hepatic portal system, which are the portal vein and its branches, which drain from most of the intestines to the liver. Portal hypertension is defined as a hepatic venous pressure gradient equal to or greater than 6 mmHg.