PANERAI WATCHES. PANERAI. Founded in 1860, in the midst of the Renaissance in Florence, Italy, Panerai has mastered the arts of creativity, technical craftsmanship, and distinguished design. In the past two centuries, Panerai timepieces have served as crucial precision instruments for the Italian navy.
Regulation of Purine Biosynthesis. The PRPP amidotransferase enzyme exists as an active monomer and an inactive polymer (see Introduction to Metabolism Lecture). IMP, GMP and AMP all inactivate the enzyme causing a shift towards the polymerized inactive form. PRPP causes a shift towards the active monomeric form.
- eg. aspirin. -aspirin inhibits COX-1 and COX-2 activity by irrevesibly acetylating Ser530 OH which lies in the wall of the tunnel. -acetylation blocks tunnel so arachidonic acid unable to bind to active site. -***Effected cells can only restore COX by synt new enzyme. - RBCs cannot synt new enzyme bc no nucleus.