Letterer-Siwe disease, multiple organ involvement. A lesion that affects bone, lung and skin; while histologically indistinct, it is more aggressive than the other forms. Prognosis. Poor if < 18 months at time of diagnosis; haemorrhagic skin lesions; hepatomegaly, anemia; thrombocytopenia; bone marrow involvement.
Cyclical Factors that Affect Business. Any business goes through different business cycles during the course of its existence. These cyclical stages include the ups and downs that a business experiences in terms of its sales volumes, revenues and product lines.
Internal Factors. The best thing about internal factors is that you can control many of them. Some factors, such as your business's reputation, image and creditworthiness, are a result of the way you run your business. Other factors, such as your organization's management structure and staffing and the physical decor of your business, are based on your business decisions, and you can change them as you see fit.