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This small nucleus contains almost half of all the brain neurons that use norepinephrine as a neurotransmitter. The locus coeruleus also projects its axons to those parts of the brain that may be associated with panic disorders (the amygdala, hippocampus, septum, cortex, brainstem, reticular formation, etc). Stimulating an animal's locus coeruleus, like stimulating its amygdala, produces anxiety behaviours.
Anxiety and the Brain: An Introduction. It should come as little surprise that your brain is the source of your anxiety. Not only does anxiety manifest itself in thoughts â it also affects your brain chemistry in a way that can alter future thoughts and affect the way your entire body operates.