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From Wikipedia, the free encyclopedia. An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. For example, the epitope is the specific piece of the antigen to which an antibody binds. The part of an antibody that binds to the epitope is called a paratope.
In summary an antigen is a molecule that binds to Ag-specific receptors, but cannot induce an immune response in the body by itself.The term originally described a structural molecule that binds specifically to an antibody.It expanded to refer to any molecule or a linear molecular fragment that can be recognized by highly variable antigen receptors (B-cell receptor or T-cell receptor) of the adaptive immune system. common analogy used to describe this is the fit between a lock and a key. In summary an antigen is a molecule that binds to Ag-specific receptors, but cannot induce an immune response in the body by itself. The term originally described a structural molecule that binds specifically to an antibody.