You may also report side effects to Bristol-Myers Squibb at 1-800 -721-5072. General information about the safe and effective use of EMPLICITI Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet.
The shape of the active site is affected by pH. This is why enzymes will only work at a specific pH, as well as a specific temperature. Change the pH and the enzyme stops working.Increasing the temperature to 60Â°C will cause a permanent change to the shape of the active site. This is why enzymes stop working when they are heated. We say they have become denatured.enaturing of enzymes. The important part of an enzyme is called the active site. This is where specific molecules bind to the enzyme and the reaction occurs. Anything that changes the shape of the active site stops the enzyme from working. This is similar to a key that opens a door lock.
Effect of temperature on enzyme activity. The temperture of a system is to some extent a measure of the kinetic energy of the molecules in the system. Thus the lower the kinetic energy, the lower the temperature of the system and, likewise, the higher the kinetic energy, the greater the temperature of the system.) The number of collisions per unit time will increase. In order to convert substrate into product, enzymes must collide with and bind to the substrate at the active site. Increasing the temperature of a system will increase the number of collisions of enzyne and substrate per unit time.