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myasthenia gravis myasthenia gravÂ·is (grÄv'Ä­s) n. A disease characterized by progressive fatigue and generalized weakness of the skeletal muscles, especially those of the face, neck, arms, and legs, caused by impaired transmission of nerve impulses following an autoimmune attack on acetylcholine receptors. Also called Goldflam disease.
History. Myasthenia Gravis (MG) is a chronic autoimmune disorder of neuromuscular transmission resulting in muscle weakness. The term myasthenia is Latin for muscle weakness, and gravis for grave or serious.Thomas Willis first described a patient with MG in 1672.There were other sporadic case descriptions over the years and in 1900, Campbell and Bramwell collected 60 cases of MG from the literature.he term myasthenia is Latin for muscle weakness, and gravis for grave or serious. Thomas Willis first described a patient with MG in 1672. There were other sporadic case descriptions over the years and in 1900, Campbell and Bramwell collected 60 cases of MG from the literature.