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Best Answer: That DNA is antiparallel means that the two strands of DNA have opposite chemical polarity, or, stated another way, their sugar-phosphate backbones run in opposite directions.
Sep 28, 2014. One of the main ways DNA's antiparallel structure affects replication is in the way DNA polymerases build the new strands of DNA. DNA polymerase is the enzyme that connects nucleotides to make the new DNA in this process. DNA polymerases only work in the 3' to 5' direction so on one of the DNA strands this is easy as it opens up in that direction.