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an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
1 Epitope â The distinct surface features of an antigen, its antigenic determinant. 2  Antigenic molecules, normally large biological polymers, usually present surface features that can act as points of interaction for specific antibodies. 3  Any such feature constitutes an epitope.