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an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
An antigen is a substance which stimulates an immune response. When exposed to an antigen, the body views it as foreign material, and takes steps to neutralize it. Typically, the body accomplishes this by making antibodies, which are intended to defend the body from invasion by potentially dangerous substances.