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A decongestant (or nasal decongestant) is a type of pharmaceutical drug that is used to relieve nasal congestion in the upper respiratory tract.The active ingredient in most decongestants is either pseudoephedrine or phenylephrine (the latter of which has disputed efficacy).These are alpha-agonists which on topical application as dilute solution (0.05-0.1%) produce local vasoconstriction.he active ingredient in most decongestants is either pseudoephedrine or phenylephrine (the latter of which has disputed efficacy). These are alpha-agonists which on topical application as dilute solution (0.05-0.1%) produce local vasoconstriction.
Definition of Decongestant. Decongestant: A drug that shrinks the swollen membranes in the nose, making it easier for a person to breathe. Decongestants can be taken orally or as nasal spray. Decongestant nasal spray should not be used for more than 5 days without a physician's recommendation. Many decongestant nasal sprays cause a worsening of symptoms (a rebound effect) when they are taken for too long and then discontinued. Decongestants should not be used by people who have high blood pressure unless they are under a physician's supervision.