Letterer-Siwe disease, multiple organ involvement. A lesion that affects bone, lung and skin; while histologically indistinct, it is more aggressive than the other forms. Prognosis. Poor if < 18 months at time of diagnosis; haemorrhagic skin lesions; hepatomegaly, anemia; thrombocytopenia; bone marrow involvement.
Cyclical Factors that Affect Business. Any business goes through different business cycles during the course of its existence. These cyclical stages include the ups and downs that a business experiences in terms of its sales volumes, revenues and product lines.
Many factors can influence your company's lead time policy, including: 1  Manufacturing environment (assemble-to-order, make-to-order) 2  Fixed or variable quantities. 3  Serial or overlap operations. 4  Fixed or variable time. 5  Number of shifts and operators. 6  Factoring by efficiency. 7  Protection.