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The average lead time for invitations is six to eight weeks before the wedding; however, destination-wedding invites should be sent anywhere from two to three months ahead of time. If you sent a save-the-date, an invitation is expected to follow.
Rachael, Wedding invitations are sent 6 to 8 weeks before a wedding. 10 weeks is more than enough for a destination wedding. More than that and you risk people getting the oh, i have plenty of time to respond and then they forget about it. Don't give them too much time but just enough to keep your special day in teh fore front of their mind. God Luck.