Letterer-Siwe disease, multiple organ involvement. A lesion that affects bone, lung and skin; while histologically indistinct, it is more aggressive than the other forms. Prognosis. Poor if < 18 months at time of diagnosis; haemorrhagic skin lesions; hepatomegaly, anemia; thrombocytopenia; bone marrow involvement.
Cyclical Factors that Affect Business. Any business goes through different business cycles during the course of its existence. These cyclical stages include the ups and downs that a business experiences in terms of its sales volumes, revenues and product lines.
Industries experience cycles of economic growth and contraction based on many factors. These include the overall health of the markets, consumer preferences and even seemingly unrelated world news and events. Although some companies perform better than others in their industry, the global factors that affect the industry as a whole must be contemplated when planning to start or grow a business.