At first, you may barely notice the symptoms of hypothyroidism, such as fatigue and weight gain, or you may simply attribute them to getting older. But as your metabolism continues to slow, you may develop more-obvious signs and symptoms. Hypothyroidism signs and symptom may include: Fatigue.
Studies have estimated that, in the United States, antibiotic resistance adds $20 billion in excess direct health care costs, with additional costs to society for lost productivity as high as $35 billion a year. The use of antibiotics is the single most important factor leading to antibiotic resistance.
This is easily under the US threshold for the definition of medical cost-effectiveness, which is $40,000 to $60,000 per QALY (about Â£30,000 in the UK). By comparison, a similar cost-effectiveness study showed that HIV combination therapy resulted in a cost of US$23,000 per QALY saved.