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This small nucleus contains almost half of all the brain neurons that use norepinephrine as a neurotransmitter. The locus coeruleus also projects its axons to those parts of the brain that may be associated with panic disorders (the amygdala, hippocampus, septum, cortex, brainstem, reticular formation, etc). Stimulating an animal's locus coeruleus, like stimulating its amygdala, produces anxiety behaviours.
By Vanessa Taylor, Sat, April 30, 2011. Anxiety disorders are complex, influenced by a number of chemical, behavioral, and situational factors. There are several neurotransmitters in the brain that seem to play a role in anxiety, including norepinephrine, serotonin and gamma-aminobutyric acid (GABA). February 19, 2018 Self Tests