Eustachian Tube Growth and Development: Anatomy/Function. Protocol Description. This study measures Eustachian tube function and facial growth over time in three groups of children: one with recurrent ear infections, one with chronic middle ear fluid, and one with little past history of otitis media.
Causes of Kartagener syndrome. Kartagener syndrome is caused by a mutation in the DNAI1 gene, which makes a cellular protein required for normal functioning cilia (cilia line the respiratory tract) and sperm motility.
Examples of these include FGFR1, where mutations result in autosomal recessive Kallmann syndrome (85). As well as the characteristic hypogonadotropic hypogonadism and anosmia, five of the 13 patients with mutations had clefts of the lip or palate.