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an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
In summary an antigen is a molecule that binds to Ag-specific receptors, but cannot induce an immune response in the body by itself.The term originally described a structural molecule that binds specifically to an antibody.It expanded to refer to any molecule or a linear molecular fragment that can be recognized by highly variable antigen receptors (B-cell receptor or T-cell receptor) of the adaptive immune system. common analogy used to describe this is the fit between a lock and a key. In summary an antigen is a molecule that binds to Ag-specific receptors, but cannot induce an immune response in the body by itself. The term originally described a structural molecule that binds specifically to an antibody.