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Considering that dopamine neurotransmission in the nucleus accumbens is thought to play an integral role in goal-directed motor behavior, these findings suggest that the prefrontal cortex influences the behavioral impact of amygdala activation via a concomitant active suppression of accumbal dopamine release.owever, during the stimulation, dopamine release increased only in the prefrontal cortex, not in the nucleus accumbens. An increase in accumbal dopamine release was observed during the stimulation if glutamate activation in the prefrontal cortex was inhibited at either presynaptic or postsynaptic levels.
Any relationship between the volume of the nucleus accumbens and its levels of BDNF is unknown, but ketamineâs effect on the size of this brain region could be linked to a decrease in the defeat-stress memories.brain, brain volume, defeat stress, depression, ketamine, nucleus accumbens, treatment-resistance.riving the ILT was sufficient to cause the rodents to display the depression-like behaviors, and silencing the ILT during defeat stress prevented the susceptible behaviors (like social avoidance) and promoted resilience. defeat stress, depression, GABA, neurons, nucleus accumbens, synapses, thalamus.