In E. coli the main enzyme is DNA polymerase III and the enzyme that replaces the RNA primer with DNA is DNA polymerase I. When the RNA primer has been replaced with DNA, there is a gap between the two Okazaki fragments and this is sealed by DNA ligase.
Little Richard's Tutti Frutti (1955) was included in the National Recording Registry of the Library of Congress in 2010, which stated that his unique vocalizing over the irresistible beat announced a new era in music..
Little Richard's original Specialty Records recording of Tutti Frutti peaked at #2 on the Billboard Rhythm and Blues Chart and #17 on the Billboard Pop Chart in 1956. The song is listed at #43 on Rolling Stone's list of the 500 Greatest Songs of All Time.