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Considering that dopamine neurotransmission in the nucleus accumbens is thought to play an integral role in goal-directed motor behavior, these findings suggest that the prefrontal cortex influences the behavioral impact of amygdala activation via a concomitant active suppression of accumbal dopamine release.owever, during the stimulation, dopamine release increased only in the prefrontal cortex, not in the nucleus accumbens. An increase in accumbal dopamine release was observed during the stimulation if glutamate activation in the prefrontal cortex was inhibited at either presynaptic or postsynaptic levels.
The nucleus basalis magnocellularis (aka Nucleus Basalis of Meynert (' NBM)) is a nucleus in the basal ganglia. This is a group of cholinergic neurons in the substantia innominata of the basal forebrain which has wide projections to the neocortex and is rich in acetylcholine and choline acetyltransferase.n Parkinson and Alzheimer diseases the nucleus undergoes degeneration. A decrease in acetylcholine production is seen in Alzheimer's disease, Lewy body dementia and some Parkinson disease patients showing abnormal brain function, leading to a general decrease of mental capacity and learning.