In E. coli the main enzyme is DNA polymerase III and the enzyme that replaces the RNA primer with DNA is DNA polymerase I. When the RNA primer has been replaced with DNA, there is a gap between the two Okazaki fragments and this is sealed by DNA ligase.
Little Richard's Tutti Frutti (1955) was included in the National Recording Registry of the Library of Congress in 2010, which stated that his unique vocalizing over the irresistible beat announced a new era in music..
Little Richard told Mojo in 1999: My greatest achievement would have to be 'Tutti Frutti.' It took me out of the kitchen-I was a dishwasher at the Greyhound bus station, making $10 a week working 12 hours a day, and 'Tutti Frutti' was a blessin' and a lesson.