Treatment by Condition Related to cosyntropin injection. Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.
The secret to juicy baked chicken breast? Bake for a short time at a high temperature. Baking for 30 minutes at 350 degrees will yield dry meat. But baking for just 20 minutes at 450 degrees will result in delightfully juicy baked chicken breast, every time.
You should bake 2 lbs. of chicken breasts in the oven at 350  degrees for one hour if the chicken is on the bone. If the chicken  is boneless it will take less time. generally bake mine at 350 degrees for 35-40 minutes and then cut at the thickest point to see if the juices run clear. If you bake too long it becomes too dry. I always bake my thawed chicken breasts at 375 degrees for 50 min. and they come out juicy and fully cooked. The juices need to run clear.