You may also report side effects to Bristol-Myers Squibb at 1-800 -721-5072. General information about the safe and effective use of EMPLICITI Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet.
The shape of the active site is affected by pH. This is why enzymes will only work at a specific pH, as well as a specific temperature. Change the pH and the enzyme stops working.Increasing the temperature to 60Â°C will cause a permanent change to the shape of the active site. This is why enzymes stop working when they are heated. We say they have become denatured.enaturing of enzymes. The important part of an enzyme is called the active site. This is where specific molecules bind to the enzyme and the reaction occurs. Anything that changes the shape of the active site stops the enzyme from working. This is similar to a key that opens a door lock.
Temperature Effects Like most chemical reactions, the rate of an enzyme-catalyzed reaction increases as the temperature is raised. A ten degree Centigrade rise in temperature will increase the activity of most enzymes by 50 to 100%.Variations in reaction temperature as small as 1 or 2 degrees may introduce changes of 10 to 20% in the results.In the case of enzymatic reactions, this is complicated by the fact that many enzymes are adversely affected by high temperatures.ariations in reaction temperature as small as 1 or 2 degrees may introduce changes of 10 to 20% in the results. In the case of enzymatic reactions, this is complicated by the fact that many enzymes are adversely affected by high temperatures.