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From Wikipedia, the free encyclopedia. An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. For example, the epitope is the specific piece of the antigen to which an antibody binds. The part of an antibody that binds to the epitope is called a paratope.
An antigen is a substance which stimulates an immune response. When exposed to an antigen, the body views it as foreign material, and takes steps to neutralize it. Typically, the body accomplishes this by making antibodies, which are intended to defend the body from invasion by potentially dangerous substances.