Letterer-Siwe disease, multiple organ involvement. A lesion that affects bone, lung and skin; while histologically indistinct, it is more aggressive than the other forms. Prognosis. Poor if < 18 months at time of diagnosis; haemorrhagic skin lesions; hepatomegaly, anemia; thrombocytopenia; bone marrow involvement.
Cyclical Factors that Affect Business. Any business goes through different business cycles during the course of its existence. These cyclical stages include the ups and downs that a business experiences in terms of its sales volumes, revenues and product lines.
Mastering some of the forces that impact your business is more challenging than handling others. The extent to which you can control them differs. You can change how internal and external factors affect your firm. You cannot make the economy grow. But, you can encourage spending. Learning more about the factors at work will better equip you.