Letterer-Siwe disease, multiple organ involvement. A lesion that affects bone, lung and skin; while histologically indistinct, it is more aggressive than the other forms. Prognosis. Poor if < 18 months at time of diagnosis; haemorrhagic skin lesions; hepatomegaly, anemia; thrombocytopenia; bone marrow involvement.
Cyclical Factors that Affect Business. Any business goes through different business cycles during the course of its existence. These cyclical stages include the ups and downs that a business experiences in terms of its sales volumes, revenues and product lines.
All businesses operate around certain business cycles. A business cycle refers to various trends that occur within a business or industry, such as growth or contraction. Often times, management decisions are impacted by where the company stands in reference to a particular cycle. Macro business cycles such as the general state of the economy also play an important role in management decisions. When the economy is in a cycle of retraction, management will act conservatively, whereas in a cycle of expansion, management may tend to act more aggressively to gain as much market share as possible.