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1. karyotype-the appearance of the chromosomal makeup of a somatic cell in an individual or species (including the number and arrangement and size and structure of the chromosomes). physical composition, composition, make-up, makeup, constitution-the way in which someone or something is composed. Translations.
Noun An organized visual profile of the chromosomes in the nucleus of a body cell of an organism. Karyotypes are prepared using cells in the metaphase stage of cell division, when chromosomal strands have coiled together and duplicated, rendering them easily visible under a microscope after staining.