You may also report side effects to Bristol-Myers Squibb at 1-800 -721-5072. General information about the safe and effective use of EMPLICITI Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet.
The shape of the active site is affected by pH. This is why enzymes will only work at a specific pH, as well as a specific temperature. Change the pH and the enzyme stops working.Increasing the temperature to 60Â°C will cause a permanent change to the shape of the active site. This is why enzymes stop working when they are heated. We say they have become denatured.enaturing of enzymes. The important part of an enzyme is called the active site. This is where specific molecules bind to the enzyme and the reaction occurs. Anything that changes the shape of the active site stops the enzyme from working. This is similar to a key that opens a door lock.
Best Answer: Denaturation is when a protein or nucleic acid loses some to all of its function. Usually, denaturation refers to enzymes (a type of protein). Enzymes can be denatured by factors like temperature and pH. Enzymes work at optimal conditions (certain temperatures, certain pH levels, etc.).If the temperature or pH is too high or low, the enzymes' shapes can change.enaturation of a protein is when the structure of the protein is changed or destroyed. This is usually because of temperature or pH. Denaturation can never be reversed. jaymerr2001 Â· 8 years ago. Thumbs up.