Letterer-Siwe disease, multiple organ involvement. A lesion that affects bone, lung and skin; while histologically indistinct, it is more aggressive than the other forms. Prognosis. Poor if < 18 months at time of diagnosis; haemorrhagic skin lesions; hepatomegaly, anemia; thrombocytopenia; bone marrow involvement.
Cyclical Factors that Affect Business. Any business goes through different business cycles during the course of its existence. These cyclical stages include the ups and downs that a business experiences in terms of its sales volumes, revenues and product lines.
Economic Factors That Influence Businesses. Demand and Supply. The demand and supply are two principal factors that affect the working of any business model. The demand is the will and ability of consumers to purchase a particular commodity, while supply is the ability of the business to provide for the demand of consumers.