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This small nucleus contains almost half of all the brain neurons that use norepinephrine as a neurotransmitter. The locus coeruleus also projects its axons to those parts of the brain that may be associated with panic disorders (the amygdala, hippocampus, septum, cortex, brainstem, reticular formation, etc). Stimulating an animal's locus coeruleus, like stimulating its amygdala, produces anxiety behaviours.
Anxiety and Brain Activation. There are two different parts to an anxiety disorder, and someone with anxiety may suffer from one or both. The first part is mental â verbal worries, nervous thoughts, etc. The second part of anxiety is physical.