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1 Urethral cancer is a disease in which malignant (cancer) cells form in the tissues of the urethra, the tube that carries urine from the bladder to outside the body. It is a rare cancer that occurs more often in women than in men.  Squamous cell carcinoma is the most common type of urethral cancer.
Urothelial carcinoma, also known as transitional cell carcinoma (TCC), is by far the most common type of bladder cancer. In fact, if you are told you have bladder cancer it is almost certain to be a urothelial carcinoma. These cancers start in the urothelial cells that line the inside of the bladder. Urothelial cells also line other parts of the urinary tract, such as the part of the kidney that connects to the ureter (called the renal pelvis), the ureters, and the urethra. Patients with bladder cancer sometimes have other tumors in these places, so the entire urinary tract needs to be checked for tumors.