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The average lead time for invitations is six to eight weeks before the wedding; however, destination-wedding invites should be sent anywhere from two to three months ahead of time. If you sent a save-the-date, an invitation is expected to follow.
You should then send out the invitations eight to ten weeks before the wedding. Since these kinds of trips typically include more events than just the ceremony and reception, you'll probably want to ask for RSVPs three to four weeks before the departure date.