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Considering that dopamine neurotransmission in the nucleus accumbens is thought to play an integral role in goal-directed motor behavior, these findings suggest that the prefrontal cortex influences the behavioral impact of amygdala activation via a concomitant active suppression of accumbal dopamine release.owever, during the stimulation, dopamine release increased only in the prefrontal cortex, not in the nucleus accumbens. An increase in accumbal dopamine release was observed during the stimulation if glutamate activation in the prefrontal cortex was inhibited at either presynaptic or postsynaptic levels.
The marijuana smokers were asked to track their cannabis use for 90 days. All were given high-resolution MRIs, and users and non-users' results were compared. Researchers examined regions of the brain involved in emotional processing, motivation and reward, called the nucleus accumbens and the amygdala. They analyzed volume, shape and density of grey matter - where most cells in brain tissue are located.