Figure Detail. Insertion or deletion of one or more nucleotides during replication can also lead to another type of mutation known as a frameshift mutation. The outcome of a frameshift mutation is complete alteration of the amino acid sequence of a protein.igure Detail. Insertion or deletion of one or more nucleotides during replication can also lead to another type of mutation known as a frameshift mutation. The outcome of a frameshift mutation is complete alteration of the amino acid sequence of a protein.
The female hormone, estrogen affects joints by keeping inflammation down, therefore, as estrogen levels begin to decline during perimenopause, joints get less and less estrogen and pain is often the result.oint pain is defined as pain/ache, stiffness or swelling in or around a joint. Menopause joint pain is usually associated with osteoporosis and arthritis. Osteoporosis â thinning of the bone due to the inability of the body to produce bone tissue.
Aching joints: A sensation of aching located in the joints. See detailed information below for a list of 46 causes of Aching joints, Symptom Checker, including diseases and drug side effect causes.esearch the causes of these symptoms that are similar to, or related to, the symptom Aching joints: 1  Joint pain (773 causes). 2  Stiff joints (258 causes). 3  Joint symptoms (1430 causes). 4  Knee pain (122 causes). 5  Ankle pain (56 causes). 6  Knuckle pain (16 causes). 7  Back pain (479 causes). 8  Elbow pain (41 causes).