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OPANAÂ® ER is an opioid agonist indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate. Limitations of Use.
Last reviewed on RxList 6/19/2015. Opana (oxymorphone hydrochloride) is a narcotic pain reliever used to treat moderate to severe pain. The extended-release form of this medication is for around-the-clock treatment of pain. Opana is available in generic form. Common side effects of Opana include nausea, vomiting, fever, constipation, increased sweating, lightheadedness, headache, dizziness, drowsiness, rash, or itching. The dose of Opana is determined by the patient's age, condition, medical status, type and severity of the pain, and other factors.