Letterer-Siwe disease, multiple organ involvement. A lesion that affects bone, lung and skin; while histologically indistinct, it is more aggressive than the other forms. Prognosis. Poor if < 18 months at time of diagnosis; haemorrhagic skin lesions; hepatomegaly, anemia; thrombocytopenia; bone marrow involvement.
Cyclical Factors that Affect Business. Any business goes through different business cycles during the course of its existence. These cyclical stages include the ups and downs that a business experiences in terms of its sales volumes, revenues and product lines.
Accounting for trends in the overall economy can help business managers make better decisions. Economic factors that commonly affect businesses include consumer confidence, employment, interest rates and inflation.ccounting for trends in the overall economy can help business managers make better decisions. Economic factors that commonly affect businesses include consumer confidence, employment, interest rates and inflation.