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an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
Origin: From antigÃ¨ne, from anti- + gÃ¨ne. Antigen. In immunology, an antigen is the substance that binds specifically to the respective antibody. Each antibody from the diverse repertoire binds a specific antigenic structure by means of its variable region interaction, in analogy to the fit between a lock and a key.