Social Security Timeline. 1  1935 The 37-page Social Security Act signed August 14 by President Franklin D. Roosevelt. 2  1937 First Social Security Cards issued by post offices, over 20 million issued in first year. 3  1937 Ernest Ackerman receives first lump-sum payout (of 17 cents) in January.
The proportion of subjects who permanently discontinued treatment due to adverse events was 0%, less than 1%, and 1% for subjects receiving Harvoni for 8, 12, and 24 weeks, respectively. The most common adverse reactions (at least 10%) were fatigue and headache in subjects treated with 8, 12, or 24 weeks of Harvoni.
The length of treatment, and whether Harvoni should be taken with ribavirin, depends on HCV genotype, amount of liver damage and prior treatment history. Most people with HCV genotype 1 or 4 without liver cirrhosis should take Harvoni without ribavirin for 12 weeks.