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Polar substances are likely to dissolve in polar solvents. For example, ionic compounds, which are very polar, are often soluble in the polar solvent water. Nonpolar substances are likely to dissolve in nonpolar solvents.or example, the solution of sodium hydroxide is exothermic, and the solution of sodium chloride is somewhat endothermic. Even if the solution is slightly endothermic, the tendency to shift to the higher entropy solution often makes ionic compounds soluble in water.
Amino acids are generally soluble in water and insoluble in non-polar organic solvents such as hydrocarbons. This again reflects the presence of the zwitterions. In water, the ionic attractions between the ions in the solid amino acid are replaced by strong attractions between polar water molecules and the zwitterions.hey are compounds containing an amino group, -NH2, and a carboxylic acid group, -COOH. The biologically important amino acids have the amino group attached to the carbon atom next door to the-COOH group. They are known as 2-amino acids. They are also known (slightly confusingly) as alpha-amino acids.