Figure Detail. Insertion or deletion of one or more nucleotides during replication can also lead to another type of mutation known as a frameshift mutation. The outcome of a frameshift mutation is complete alteration of the amino acid sequence of a protein.igure Detail. Insertion or deletion of one or more nucleotides during replication can also lead to another type of mutation known as a frameshift mutation. The outcome of a frameshift mutation is complete alteration of the amino acid sequence of a protein.
The female hormone, estrogen affects joints by keeping inflammation down, therefore, as estrogen levels begin to decline during perimenopause, joints get less and less estrogen and pain is often the result.oint pain is defined as pain/ache, stiffness or swelling in or around a joint. Menopause joint pain is usually associated with osteoporosis and arthritis. Osteoporosis â thinning of the bone due to the inability of the body to produce bone tissue.
One of the more common causes of pain in the back of the knee joint, specifically, is a popliteal synovial cyst, which is also known as a bakerâs cyst. This fluid-filled cyst at the back of the leg often forms in response to arthritis or other cartilage damage. The bulge creates a feeling of tightness behind the knee as well as stiffness and swelling and pain behind the knee and calf. For many, this pain intensifies when flexing or fully extending the leg.