Figure Detail. Insertion or deletion of one or more nucleotides during replication can also lead to another type of mutation known as a frameshift mutation. The outcome of a frameshift mutation is complete alteration of the amino acid sequence of a protein.igure Detail. Insertion or deletion of one or more nucleotides during replication can also lead to another type of mutation known as a frameshift mutation. The outcome of a frameshift mutation is complete alteration of the amino acid sequence of a protein.
The female hormone, estrogen affects joints by keeping inflammation down, therefore, as estrogen levels begin to decline during perimenopause, joints get less and less estrogen and pain is often the result.oint pain is defined as pain/ache, stiffness or swelling in or around a joint. Menopause joint pain is usually associated with osteoporosis and arthritis. Osteoporosis â thinning of the bone due to the inability of the body to produce bone tissue.
Osteoarthritis (OA) is a form of degenerative joint pain caused by wear and tear on your joints. As you age, the cartilage that cushions your joints starts to wear down, causing the bones to rub together. The bone-on-bone action leads to inflammation of the joints. Osteoarthritis most commonly affects the joints in your arms and legs, including your fingers, wrists, knees, ankles, and hips. The lower back is also a common source of OA pain. Let your doctor know if youâre suffering from the early symptoms of osteoarthritis.