You may also report side effects to Bristol-Myers Squibb at 1-800 -721-5072. General information about the safe and effective use of EMPLICITI Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet.
The shape of the active site is affected by pH. This is why enzymes will only work at a specific pH, as well as a specific temperature. Change the pH and the enzyme stops working.Increasing the temperature to 60Â°C will cause a permanent change to the shape of the active site. This is why enzymes stop working when they are heated. We say they have become denatured.enaturing of enzymes. The important part of an enzyme is called the active site. This is where specific molecules bind to the enzyme and the reaction occurs. Anything that changes the shape of the active site stops the enzyme from working. This is similar to a key that opens a door lock.
If the temperature is increased then the enzyme becomes denatured. This happens at about 50-60 degrees in the human body. When enzymes are heated up too much they vibrate so v â¦ igorously that the bonds holding the protein structure in its specific shape break.s enzymes are made up of protein, they can be denatured by the means of physical action like due to change in pH, temp. and pressure, or by cemical procedure by acting some enzymes on them they can be denatured.