The time difference between GMT and EST is 5 hours. That means when it's 12.00 noon in Gâ¦reenwich, the time in Toronto is 7.00AM Toronto also observes Daylight Saving Time known as Eastern Daylight Time (EDT) and during that period, the time difference between GMT and EDT is 4 hours. EST = GMT - 5 hrs EDT = GMT - 4 hrs. Hank W.
coagulation factors factors essential to normal blood clotting, whose absence, diminution, or excess may lead to abnormality of the clotting. Twelve factors, commonly designated by Roman numerals, have been described (IâV and VIIâXIII; VI is no longer considered to have a clotting function). (See table 6.).
1 Liver dysfunction or disease â almost all coagulation factors are produced in the liver; liver disease may result in decreased production of factors.  Vitamin K deficiency â the synthesis of several coagulation factors (II, VII, IX, X) requires vitamin K.