Figure Detail. Insertion or deletion of one or more nucleotides during replication can also lead to another type of mutation known as a frameshift mutation. The outcome of a frameshift mutation is complete alteration of the amino acid sequence of a protein.igure Detail. Insertion or deletion of one or more nucleotides during replication can also lead to another type of mutation known as a frameshift mutation. The outcome of a frameshift mutation is complete alteration of the amino acid sequence of a protein.
The female hormone, estrogen affects joints by keeping inflammation down, therefore, as estrogen levels begin to decline during perimenopause, joints get less and less estrogen and pain is often the result.oint pain is defined as pain/ache, stiffness or swelling in or around a joint. Menopause joint pain is usually associated with osteoporosis and arthritis. Osteoporosis â thinning of the bone due to the inability of the body to produce bone tissue.
Osteoarthritis is an inflammation of the joint that occurs with the wearing away of the articular cartilage, the smooth covering on the ends of bones. Inflammatory arthritis of the hip is characterized by a dull, aching pain in the groin, outer thigh, or buttocks.he hip joint is one of the most common sites for osteoarthritis. This condition begins with a small amount of cartilage disintegration, resulting in some local inflammation. The process continues as the cartilage erodes and bone spurs form.