You may also report side effects to Bristol-Myers Squibb at 1-800 -721-5072. General information about the safe and effective use of EMPLICITI Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet.
The shape of the active site is affected by pH. This is why enzymes will only work at a specific pH, as well as a specific temperature. Change the pH and the enzyme stops working.Increasing the temperature to 60Â°C will cause a permanent change to the shape of the active site. This is why enzymes stop working when they are heated. We say they have become denatured.enaturing of enzymes. The important part of an enzyme is called the active site. This is where specific molecules bind to the enzyme and the reaction occurs. Anything that changes the shape of the active site stops the enzyme from working. This is similar to a key that opens a door lock.
Increasing temperature increases the rate of enzyme activity up to a point when it become too hot, when the enzyme is denatured and so activity stops. Increasing temperature increases the rate because the substrate has more kinetic energy, so is more likely to collide with the enzyme for the reaction to take place.Too much heat causes the bonds which hold the enzyme in its very specific shape to break, meaning it can no longer function (is denatured).ncreasing temperature increases the rate because the substrate has more kinetic energy, so is more likely to collide with the enzyme for the reaction to take place. Too much heat causes the bonds which hold the enzyme in its very specific shape to break, meaning it can no longer function (is denatured).