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MSM For Dogs MSM is a naturally occurring nutritional supplement that has a variety of uses. Veterinarians have been using it since the 1980s to treat several different health problems in dogs and other animals.
That's not an easy question to answer because there's not a lot of research on the long-term effects of the dietary supplement called methylsulfonylmethane (MSM). MSM is formed using dimethylsulfoxide (DMSO), an organic form of sulfur that's also used as a dietary supplement. Animals observed for 90 days on a daily dose of MSM five to seven times greater than what's typically used in people had no serious problems. Stomach upset, diarrhea and headache have been reported in human trials of MSM lasting up to 12 weeks. However, people taking a placebo also reported similar symptoms.