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The last part of a river. A river usually ends by flowing into an ocean, a lake or a bigger river. The place where the river flows out into a bigger body of water is called the 'mouth' of the river. As a river flows towards its mouth, the countryside around the river often changes from hilly to flat.
Upstream vs downstream. Upstream direction is the end of the waterway from where the flow of water originates. Where the flow ends, at the opposite end of the waterway. For exemple, from Kingston to Toronto you are heading upstream, the water emptying from a river back into the ocean. Kingston to Cornwall is downstream.