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myasthenia gravis myasthenia gravÂ·is (grÄv'Ä­s) n. A disease characterized by progressive fatigue and generalized weakness of the skeletal muscles, especially those of the face, neck, arms, and legs, caused by impaired transmission of nerve impulses following an autoimmune attack on acetylcholine receptors. Also called Goldflam disease.
Background Myasthenia gravis is an autoimmune disease involving the neuromuscular junction leading to skeletal muscle weakness and fatigability. In ocular myasthenia gravis (OMG), the symptoms are confined to the extraocular and eyelid muscles.