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A decongestant (or nasal decongestant) is a type of pharmaceutical drug that is used to relieve nasal congestion in the upper respiratory tract.The active ingredient in most decongestants is either pseudoephedrine or phenylephrine (the latter of which has disputed efficacy).These are alpha-agonists which on topical application as dilute solution (0.05-0.1%) produce local vasoconstriction.he active ingredient in most decongestants is either pseudoephedrine or phenylephrine (the latter of which has disputed efficacy). These are alpha-agonists which on topical application as dilute solution (0.05-0.1%) produce local vasoconstriction.
Decongestant nasal sprays can be used at night for a couple of days to decongest while avoiding the insomnia caused by oral decongestants. But using this medication for 3 days or more can lead to rebound congestion even worse than the original symptoms--a condition called rhinitis medicamentosa.