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This small nucleus contains almost half of all the brain neurons that use norepinephrine as a neurotransmitter. The locus coeruleus also projects its axons to those parts of the brain that may be associated with panic disorders (the amygdala, hippocampus, septum, cortex, brainstem, reticular formation, etc). Stimulating an animal's locus coeruleus, like stimulating its amygdala, produces anxiety behaviours.
But Iâm going to suggest that there are three distinct causes of speech anxiety. These three different causes of speaking anxiety relate to three different areas of the brain â the Old Brain (itâs called this in neuroâpopâ books but is more correctly called the Hindbrain), Midbrain and the New Brain (again more correctly called the Forebrain).