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This small nucleus contains almost half of all the brain neurons that use norepinephrine as a neurotransmitter. The locus coeruleus also projects its axons to those parts of the brain that may be associated with panic disorders (the amygdala, hippocampus, septum, cortex, brainstem, reticular formation, etc). Stimulating an animal's locus coeruleus, like stimulating its amygdala, produces anxiety behaviours.
The hippocampus is the part of the brain that encodes threatening events into memories.. Your Brain May Become Wired for Anxiety It's thought that anxiety disorders may result from a combination of nature (your genetics) and nurture (your environment). For instance, if you grow up in an environment with frequent yelling or abuse.