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Albert Einstein's contribution to mathematics is his famous E=mc2. This is one of his most well-known accomplishments. One of Einstein's great insights was to realize that matter and energy are really different forms of the same thing.
Newton also made seminal contributions to optics and shares credit with Gottfried Leibniz for the development of calculus. He is particularly remembered for his applications of mathematics to mechanics, especially fluid mechanics, and for his pioneering work in probability and statistics.