At first, you may barely notice the symptoms of hypothyroidism, such as fatigue and weight gain, or you may simply attribute them to getting older. But as your metabolism continues to slow, you may develop more-obvious signs and symptoms. Hypothyroidism signs and symptom may include: Fatigue.
Studies have estimated that, in the United States, antibiotic resistance adds $20 billion in excess direct health care costs, with additional costs to society for lost productivity as high as $35 billion a year. The use of antibiotics is the single most important factor leading to antibiotic resistance.
We found that diseases with a prevalence of 10,000 or less in the US generally support premium pricing of greater than $200,000 per year, especially for biologics. There is a first mover advantage in orphan indications, and certain indications support multiple drugs at high prices.