Letterer-Siwe disease, multiple organ involvement. A lesion that affects bone, lung and skin; while histologically indistinct, it is more aggressive than the other forms. Prognosis. Poor if < 18 months at time of diagnosis; haemorrhagic skin lesions; hepatomegaly, anemia; thrombocytopenia; bone marrow involvement.
Cyclical Factors that Affect Business. Any business goes through different business cycles during the course of its existence. These cyclical stages include the ups and downs that a business experiences in terms of its sales volumes, revenues and product lines.
The factors that affect the location of a business include: Level of competition from similar vendors/businessesAvailability/accessibility for/to customersAccessibility to suâ¦ppliersConsumer demand of such a business in a certain locality (i.e., if your business is the only coffee shop in town, you will get lots of customers.