Letterer-Siwe disease, multiple organ involvement. A lesion that affects bone, lung and skin; while histologically indistinct, it is more aggressive than the other forms. Prognosis. Poor if < 18 months at time of diagnosis; haemorrhagic skin lesions; hepatomegaly, anemia; thrombocytopenia; bone marrow involvement.
Cyclical Factors that Affect Business. Any business goes through different business cycles during the course of its existence. These cyclical stages include the ups and downs that a business experiences in terms of its sales volumes, revenues and product lines.
A business cycle refers to the periodic expansion and contraction a company experiences. While the concept often is used in relation to the larger economy, its phases have applications to each particular business or industry. As generally defined, the business cycle has four components -- contraction, recession, expansion and peak. It takes years for the domestic economy to cycle through all four components, but these components can occur on an annual basis for seasonal businesses.