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Bake the Brisket. 1  Place a fat-trimmed 3- to 3-1/2-pound fresh beef brisket in a 13x9x2-inch baking pan. 2  Pour the cooking liquid over the meat. 3  Cover the pan with foil. 4  Bake in a 325 degrees F oven about 3 hours or until tender, turning once halfway through cooking time.
The best cooking temperature for brisket depends on the method that is being used to cook it and the desired doneness of the meat afterward. When using a barbeque or similar cooking method, it is typically best for someone to cook brisket at about 225Â°F (about 107Â°C) to 250Â°F (about 121Â°C).ow heat allows the meat to cook slowly, which results in an excellent outer crust without burning or the meat becoming dry. The best temperature for brisket cooked on a grill is around 225Â°F (about 107Â°C) to 250Â°F (about 121Â°C), though cooking on a grill or in a smoker can be done as low as about 210Â°F (about 99Â°C).