Figure Detail. Insertion or deletion of one or more nucleotides during replication can also lead to another type of mutation known as a frameshift mutation. The outcome of a frameshift mutation is complete alteration of the amino acid sequence of a protein.igure Detail. Insertion or deletion of one or more nucleotides during replication can also lead to another type of mutation known as a frameshift mutation. The outcome of a frameshift mutation is complete alteration of the amino acid sequence of a protein.
The female hormone, estrogen affects joints by keeping inflammation down, therefore, as estrogen levels begin to decline during perimenopause, joints get less and less estrogen and pain is often the result.oint pain is defined as pain/ache, stiffness or swelling in or around a joint. Menopause joint pain is usually associated with osteoporosis and arthritis. Osteoporosis â thinning of the bone due to the inability of the body to produce bone tissue.
Generally, pain in the two joints is caused by arthritis. This can either be rheumatoid arthritis (RA) or osteoarthritis (OA). When people are over 40, they are more likely to have OA. This starts slowly, hitting joints used the most, such as ankles, knees, hips, hands and wrists. OA joint pain is caused by the cartilage breaking down, which serves as a shock absorber or cushion to your joints. Women are more likely to have RA than men. It tends to debilitate and deform the joints through time.