Figure Detail. Insertion or deletion of one or more nucleotides during replication can also lead to another type of mutation known as a frameshift mutation. The outcome of a frameshift mutation is complete alteration of the amino acid sequence of a protein.igure Detail. Insertion or deletion of one or more nucleotides during replication can also lead to another type of mutation known as a frameshift mutation. The outcome of a frameshift mutation is complete alteration of the amino acid sequence of a protein.
The female hormone, estrogen affects joints by keeping inflammation down, therefore, as estrogen levels begin to decline during perimenopause, joints get less and less estrogen and pain is often the result.oint pain is defined as pain/ache, stiffness or swelling in or around a joint. Menopause joint pain is usually associated with osteoporosis and arthritis. Osteoporosis â thinning of the bone due to the inability of the body to produce bone tissue.
Polymyalgia rheumatica (PMR) causes stiffness and muscle aches, particularly in the neck, shoulders and hips. Symptoms can appear almost overnight in some cases with no relief.tiffness is usually worse in the morning. Trying to move without pain can leave those with PMR exhausted for the rest of the day, and pain may also be bad enough to awaken them at night. Sometimes the aching and stiffness develop suddenly. In other cases, they appear more gradually. Other signs include: 1  Fatigue.