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Therapeutic Uses. Significant but not entirely consistent evidence suggests that regular use of NAC is helpful for individuals with chronic bronchitis (a condition commonly associated with smoking and emphysema) in reducing frequency of acute flare-ups of the condition.
Acetaminophen toxicity: Strong scientific evidence supports the use of N-acetylcysteine (NAC) as an antidote to acetaminophen overdose. Bronchiolitis (sulfur mustard-induced): NAC is commonly used for lung infections and sputum (phlegm and mucus) clearance. In human study, NAC reduced symptoms in patients with sulfur mustard-induced bronchiolitis (swelling in the small air passages of the lungs). Additional study is needed before a conclusion can be made. Chronic bronchitis: NAC has been used to treat chronic bronchitis since the 1960s. Evidence from some human studies suggests that NAC may benefit patients with chronic bronchitis. Other studies show a lack of benefit. Further study is required before firm conclusions can be made.