Paracrine signaling produces molecules of a local regulator. Synaptic signaling produces neurotransmitters. Paracrine signaling affects all cells in the vicinity of the transmitting cell. Synaptic signaling affect a single target cell.
Sterling Jewelers, Inc. is an American specialty jewelry company headquartered in Akron, Ohio. The company was founded in 1910 by Henry Shaw (the father of Jerry Shaw, the chairman emeritus of Sterling today), from LeRoy's Jewelers in Lorain, Ohio.
Master jeweler and goldsmith Reggie Akdogan, originally from Istanbul, Turkey, now a long-time American citizen, established The Precious Gem in 1980. His business started out as a small workshop in Williamsburg, Virginia, before moving to its current location in the heart of Colonial Williamsburg, VA.