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1. karyotype-the appearance of the chromosomal makeup of a somatic cell in an individual or species (including the number and arrangement and size and structure of the chromosomes). physical composition, composition, make-up, makeup, constitution-the way in which someone or something is composed. Translations.
a karyotype is a picture of all the chromosomes in a cell. These pictures are used to check for chromosomal abnormalities, such as too few or too much which can result in a ge â¦ netic disability. Such as Down Syndrome.