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From Wikipedia, the free encyclopedia. An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. For example, the epitope is the specific piece of the antigen to which an antibody binds. The part of an antibody that binds to the epitope is called a paratope.
1 Epitope â The distinct surface features of an antigen, its antigenic determinant. 2  Antigenic molecules, normally large biological polymers, usually present surface features that can act as points of interaction for specific antibodies. 3  Any such feature constitutes an epitope.