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Back in the mesolimbic pathway, dopamine can play a role in psychosis, and many antipsychotics for treatment of schizophrenia target dopamine. Dopamine is involved in the frontal cortex in executive functions like attention.t has far more roles in the brain to play. For example, dopamine plays a big role in starting movement, and the destruction of dopamine neurons in an area of the brain called the substantia nigra is what produces the symptoms of Parkinsonâs disease.
It is believed that dopamine may play a role in the development of schizophrenia. As explained by K. L. Davis and colleagues in the April 2001 issue of The American Journal of Psychiatry, excess dopamine can affect certain brain regions, allowing the symptoms of schizophrenia to emerge.