You may also report side effects to Bristol-Myers Squibb at 1-800 -721-5072. General information about the safe and effective use of EMPLICITI Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet.
The shape of the active site is affected by pH. This is why enzymes will only work at a specific pH, as well as a specific temperature. Change the pH and the enzyme stops working.Increasing the temperature to 60Â°C will cause a permanent change to the shape of the active site. This is why enzymes stop working when they are heated. We say they have become denatured.enaturing of enzymes. The important part of an enzyme is called the active site. This is where specific molecules bind to the enzyme and the reaction occurs. Anything that changes the shape of the active site stops the enzyme from working. This is similar to a key that opens a door lock.
Temperature, pH and enzymes The activity of enzymes is affected by temperature and pH pH: Scale of acidity/alkalinity. pH below 7 = acidic, pH above 7 = alkaline. Temperature and enzymes. As the temperature increases, so does the rate of reaction. But very high temperatures denature denature: disable by changing the normal qualities or nature of something enzymes.