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The carpometacarpal joint of the thumb, also known as the first carpometacarpal joint, or the trapeziometacarpal joint (TMC) because it connects the trapezium to the first metacarpal bone, plays an irreplaceable role in the normal functioning of the thumb.
Rheumatoid arthritis (RA) and other forms of inflammatory arthritis can also damage the first CMC joint â also known as the trapeziometacarpal joint (TMC). David S. Ruch, MD, chief of the orthopaedic hand service at Duke University in Durham, N.C., says women, especially those older than 50 are 10 to 20 times more likely than men to develop thumb arthritis, though no one is quite sure why.