Polycystic kidney disease (PKD or PCKD, also known as polycystic kidney syndrome) is a genetic disorder in which abnormal cysts develop and grow in the kidneys. Cystic disorders can express themselves at any point, infancy, childhood, or adulthood.The disease occurs in humans and some other animals.PKD is characterized by the presence of multiple cysts (hence, polycystic) typically in both kidneys; however, 17% of cases initially present with observable disease in one kidney, with most cases progressing to bilateral disease in adulthood.utosomal dominant polycystic kidney disease (ADPKD) is the most common of all the inherited cystic kidney diseases with an incidence of 1:500 live births. Studies show that 10% of end-stage kidney disease (ESKD) patients being treated with dialysis in Europe and the U.S. were initially diagnosed and treated for ADPKD.
The Sacramento River is the largest river and watershed system in California (by discharge, it is the second largest U.S. river draining into the Pacific, after the Columbia River).
The Sacramento River is the principal river of Northern California in the United States, and is the largest river in California.Rising in the Klamath Mountains, the river flows south for 445 miles (716 km) before reaching the SacramentoâSan Joaquin River Delta and San Francisco Bay.bout 10 miles (16 km) downstream, it flows into the city of Sacramento, California and receives the American River, its second largest tributary. Here the river splits into two: the main stem and the artificial Sacramento Deep Water Ship Channel.