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Orchitis (or-KIE-tis) is an inflammation of one or both testicles. It is usually caused by a bacterial infection or by the mumps virus. Bacterial orchitis can be caused by sexually transmitted infections (STIs), particularly gonorrhea or chlamydia. Bacterial orchitis often results from epididymitis, an inflammation of the coiled tube (epididymis) at the back of the testicle that stores and carries sperm. In that case, it's called epididymo-orchitis.
Orchitis Overview. Orchitis is inflammation of one or both testicles in men, usually caused by an infection. Orchitis can result from the spread of bacteria through the blood from other locations in your body. It also can be a progression of epididymitis, an infection of the tube that carries semen out of the testicles.