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This condition can be caused by certain medications and by infections. In some cases, it is caused by a cancer or precancerous condition. Myelofibrosis, bone marrow scarring that can result from various hematologic cancers, typically leads to low blood counts. Pancytopenia can also be caused by aplastic anemia, a bone marrow failure disorder that affects blood cell production.
The only treatment for myelofibrosis is a bone marrow transplant. Myelofibrosis can cause the spleen and liver to enlarge in an attempt to provide the body with more blood cells. Symptoms of myelofibrosis may include fullness or pressure in the stomach.