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Wiktionary (0.00 / 0 votes) Rate this definition: disease (Noun). An abnormal condition of the body or mind that causes discomfort or dysfunction; distinct from injury insofar as the latter is usually instantaneously acquired. The tomato plants had some kind of disease that left their leaves splotchy and fruit withered. disease (Noun). Any abnormal or harmful condition, as of society, people's attitudes, way of living etc. disease (Verb). To cause unease; to annoy, irritate. disease (Verb). To infect with a disease.
A disease is a particular abnormal condition that affects part or all of an organism and that consists of a disorder of a structure or function. The study of disease is called pathology, which includes the study of cause. Disease is often construed as a medical condition associated with specific symptoms and signs.