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Antibiotics will stay in your system fro 7 to 10 days.... Antibiotics will stay in your system fro 7 to 10 days. The actual time will depend upon the type of antibiotic taken, the dosage of the antibiotic taken and individual human body as well. Some antibiotics may stay for shorter durations than this also. jack perry.
Confidence votes 214. Antibiotics take 2-3 weeks to leave your system, but it can vary depending on the type of antibiotic, such as protein or non-protein bound, the patient's metabolism, their liver function, and their kidney function. Antibiotics taken while on birth control pills cause decrease in the effectiveness of BCP.