Duloxetine is also sometimes used to treat stress urinary incontinence (leakage of urine during physical activity such as coughing, sneezing, laughing, and exercise) in women. Talk to your doctor about using this medication to treat your condition.
Water's density maximum is a product of the same phenomenon. Close to the freezing point, the water molecules start to arrange locally into ice-like structures. This creates some openness in the liquid water, which tends to decrease its density.
The increase in pressure should lower the freezing temperature of the water, reducing it's expansion due to freezing. The increase in pressure would also act to increase the temperature of the water. However if you kept drawing heat from the system you would end up with water in a state where it wanted to freeze, but due to environmental limitations could not. Therefore the reaction would result in supercooled water.