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High BUN indicates increased protein breakdown, which is associated with decreased immune function. A study shows that patients with elevated BUN (> 20 mg/dl) have an increased risk of infection (R). High BUN is associated with increased mortality in critically ill patients (R, R, R, R).
Urea is eliminated from your body when your kidneys filter it out of your blood and into your urine. A healthy range for BUN is between 4 to 17 mg/dL. Anywhere between 18 to 21 mg/dL is a sign that you may be eating too much protein, and possibly that your kidneys are under excessive strain.