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1 Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36. Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36.
Ghrelin is a hormone produced by specialized cells that line the stomach and the pancreas. In the stomach, cells that secrete ghrelin include the P/D1 cells in the fundus or upper part of the stomach and in the pancreas, ghrelin secreting cells are called epsilon cells.f the ventromedial hypothalamus is removed, feeding increases, leading to weight gain and severe obesity. A hormone that counteracts the effects of ghrelin is leptin, which is produced by the fat or adipose tissue in the body. Leptin induces satiation or a feeling of fullness after a meal.