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This condition can be caused by certain medications and by infections. In some cases, it is caused by a cancer or precancerous condition. Myelofibrosis, bone marrow scarring that can result from various hematologic cancers, typically leads to low blood counts. Pancytopenia can also be caused by aplastic anemia, a bone marrow failure disorder that affects blood cell production.
1 There is currently no effective treatment to cure or slow the progression of primary myelofibrosis. 2  Cytoreductive therapy may be tried to reduce the number of cells in a lesion, usually a malignancy. 3  Immunomodulatory drugs may be used.  Blood transfusions may be administered, as needed, to treat anemia.