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Antibiotics will stay in your system fro 7 to 10 days.... Antibiotics will stay in your system fro 7 to 10 days. The actual time will depend upon the type of antibiotic taken, the dosage of the antibiotic taken and individual human body as well. Some antibiotics may stay for shorter durations than this also. jack perry.
Relevance. Rating Newest Oldest. Best Answer: Antibiotics usually start working in 24 to 36 hours, however when the infection is in a tooth or jaw (bone) it takes longer merely because the blood supply isn't as good in that kind of tissue. Warm compresses help to increase the blood flow to the area and carry the meds to the area.