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Medical Definition of ALANINE AMINOTRANSFERASE. : an enzyme which promotes transfer of an amino group from glutamic acid to pyruvic acid and which when present in abnormally high levels in the blood is a diagnostic indication of liver diseaseâabbreviation ALT; called also glutamic pyruvic transaminase.weet. : an enzyme which promotes transfer of an amino group from glutamic acid to pyruvic acid and which when present in abnormally high levels in the blood is a diagnostic indication of liver diseaseâabbreviation ALT; called also glutamic pyruvic transaminase.
alanine aminotransferase (ALT), an enzyme normally present in the serum and tissues of the body, especially the tissues of the liver. This enzyme catalyzes the transfer of an amino group from alanine to alpha-ketoglutarate, forming pyruvate and glutamate.The reaction is reversible.The enzyme is released into the serum as a result of tissue injury and increases in persons with acute liver damage. Normal findings are 5 to 35 IU/L. Also called alanine transferase, glutamic pyruvic transaminase. Compare aspartate aminotransferase.n enzyme transferring amino groups from l-alanine to 2-ketoglutarate, or the reverse (from l-glutamate to pyruvate); one d-alanine transaminase effects the same reaction, but using d-alanine and d-glutamate. Serum concentration is increased in viral hepatitis and myocardial infarction.