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1 Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36. Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36.
If your stomach is growling, then it is producing ghrelin. Ghrelin communicates with your brain and triggers the release of an additional hormone called neuropeptide Y, which is a hormone secreted by the hypothalamus to stimulate hunger. Your hypothalamus is the part of your brain that regulates appetite and hunger. In fact, your hypothalamus stays pretty busy with this function, taking in data from different sources. Tucked up inside your brain, this collection of nervous tissue receives inputs from the vagus nerve, which is actually a cranial nerve that sends signals from the gastrointestinal tract to the brain.