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This condition can be caused by certain medications and by infections. In some cases, it is caused by a cancer or precancerous condition. Myelofibrosis, bone marrow scarring that can result from various hematologic cancers, typically leads to low blood counts. Pancytopenia can also be caused by aplastic anemia, a bone marrow failure disorder that affects blood cell production.
Quick Answer. A low white blood cell count is an indicator of serious infections, bone marrow deficiency, autoimmune disorders and certain types of cancer, according to MedlinePlus. Several types of medications, such as anti-seizure drugs and chemotherapy drugs, also cause decreased WBC counts.