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This condition can be caused by certain medications and by infections. In some cases, it is caused by a cancer or precancerous condition. Myelofibrosis, bone marrow scarring that can result from various hematologic cancers, typically leads to low blood counts. Pancytopenia can also be caused by aplastic anemia, a bone marrow failure disorder that affects blood cell production.
Often, myelofibrosis is not treated because the only treatment available is bone marrow transplant. Since this involves a fairly difficult procedure and chemotherapy afterwards, those who are much older than 50 are considered at poor risk for surviving the treatment.