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This condition can be caused by certain medications and by infections. In some cases, it is caused by a cancer or precancerous condition. Myelofibrosis, bone marrow scarring that can result from various hematologic cancers, typically leads to low blood counts. Pancytopenia can also be caused by aplastic anemia, a bone marrow failure disorder that affects blood cell production.
What is Myelofibrosis? Myelofibrosis is the scarring of bone marrow. Symptoms include bone pain, fatigue, anemia, bruising, enlarged spleen, and low blood platelet count. Treatment for myelofibrosis includes chemotherapy, radiation therapy, and blood transfusions. A common drug class used to treat myelofibrosis is the kinase inhibitors drug class.