The most common and severe form of Î±1-antitrypsin deficiency is caused by the Z mutation, a single base substitution (Gul342-Lys) in the Î±1-antitrypsin gene. Misfolding of proteins during synthesis can initiate an ordered polymerization, which leads to aggregation of the protein within the cell.
Main article: List of place names of Native American origin in California. 1  Malibu â from VentureÃ±o <Umalibu>, perhaps reflecting [(hu)maliwu], it (the surf) makes a loud noise all the time over there. 2  Pismo Beach - from Chumash Pismu for tar. 3  Simi Valley â from VentureÃ±o <Simiyi>.
Josephine Bowser Lillie was among Native Americans granted an 80-acre (320,000 m2) allotment of land within the Yakama Reservation. Of mixed Native American/European ancestry and Yakama identification, she is known as The Mother of Toppenish.. She platted the north 40 acres (160,000 m2) of her land. These tracts became the first deeded land to be sold on the Yakama Nation Reservation. The town is generally called TáºÃ¡pniÅ¡ in the Sahaptin language of the Yakama. This is the likely source of the name Toppenish. The word means âprotruded, stuck outâ and recalls a landslide that occurred on the ridge south of White Swan, Washington.