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The drugâs initial approval noted mild side effects such as vomiting, itching, lethargy and diarrhea. Some 70 million doses of Trifexis have been distributed through 15,000 veterinary clinics, said Elanco spokeswoman Julie Lawless.
The most common side effects of tricyclics (and tetracyclics) include: 1  Dry mouth. 2  Blurred vision. 3  Constipation. Urinary retention. 4  Drowsiness. Increased appetite leading to weight 5  gain. Drop in blood pressure when moving from sitting to standing, which can cause lightheadedness.  Increased sweating.