The most common and severe form of Î±1-antitrypsin deficiency is caused by the Z mutation, a single base substitution (Gul342-Lys) in the Î±1-antitrypsin gene. Misfolding of proteins during synthesis can initiate an ordered polymerization, which leads to aggregation of the protein within the cell.
Main article: List of place names of Native American origin in California. 1  Malibu â from VentureÃ±o <Umalibu>, perhaps reflecting [(hu)maliwu], it (the surf) makes a loud noise all the time over there. 2  Pismo Beach - from Chumash Pismu for tar. 3  Simi Valley â from VentureÃ±o <Simiyi>.
Pocahontas, also called Matoaka and Amonute, Christian name Rebecca (born c. 1596 ce, near present-day Jamestown, Virginia, U.S.âdied March 1617, Gravesend, Kent, England), Powhatan Indian woman who fostered peace between English colonists and Native Americans by befriending the settlers at the Jamestown Colony in Virginia and eventually marrying ...