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1 When to take: Depending on the severity of the sleep problem, take time-released melatonin 1 to 3 hours prior to the time you usually fall asleep. 2  Since time release melatonin only lasts for 3 â 4 hours, any need to shift sleep schedules more than 3 hours may require taking another pill in 3 or 4 hours.
Data taken from a study of one 3-year-old boy with SMS supplemented with melatonin 6 mg or placebo over 12 consecutive nights suggest that melatonin supplementation is associated with a shorter time to sleep induction (3.36 Â± 2.23 hours with melatonin vs 7.32 Â± 3.71 hours with placebo, P < 0.05).