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Dominating this era was Titanoboa, the undisputed largest snake in the history of the world. Most of the fossil record of ancient snakes is comprised of vertebrae like the one that launched the Titanoboa investigation.
Please try again later. The Biggest Snake in the history of the world is the Titanoboa, a giant prehistoric snake that could easily eat a man, or multiple humans for breakfast. In 2004 the Smithsonian Tropical Research Institute led an expedition to cerrejon, the largest mining operation in Colombia.