in the x direction, the water wants to flow in that direction) For a given hydraulic. conductivity, the vertical flow rate depends on the sum of the gravitational potential energy. gradient per unit weight of water (dz/dz =1) and the vertical gradient in soil water pressure.
Origin and spread of the 1278insTATC mutation causing TayâSachs disease in Ashkenazi Jews: Genetic drift as a robust and parsimonious hypothesis. Human Genetics 114 (4): 366â376. pmid 14727180.
Tay-Sachs disease is a rare inherited disorder that progressively destroys nerve cells (neurons) in the brain and spinal cord. The most common form of Tay-Sachs disease becomes apparent in infancy.Infants with this disorder typically appear normal until the age of 3 to 6 months, when their development slows and muscles used for movement weaken.ecause Tay-Sachs disease impairs the function of a lysosomal enzyme and involves the buildup of GM2 ganglioside, this condition is sometimes referred to as a lysosomal storage disorder or a GM2-gangliosidosis.