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1 Ibuprofen (MotrinÂ®, AdvilÂ®), naproxen (AleveÂ®) and aspirin are non-steroidal anti-inflammatory drugs, abbreviated NSAIDs. 2  They are available over-the-counter (OTC). 3  Other NSAIDs require a prescription. 4  NSAIDs are used to treat pain, fever, and inflammation.dults take ibuprofen and naproxen for headaches, muscle aches, pain from injuries, menstrual cramps, and arthritis pain, among other reasons. Adults may also take prescription NSAIDs, including meloxicam (Mobic Â®), piroxicam (Feldene Â®), ketorolac (Toradol Â®), diclofenac (Voltaren Â®), and etodolac (Lodine Â®).