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Introduction. Ibuprofen is a painkiller, which is available over-the-counter, without a prescription. It is one of a group of painkillers called non-steroidal anti-inflammatory drugs (NSAIDs), and can be used to:1  ease mild to moderate pain â such as toothache, migraines and period pain.buprofen is a painkiller, which is available over-the-counter, without a prescription.