renin-angiotensin-aldosterone system the regulation of sodium balance, fluid volume, and blood pressure by secretion of renin in response to reduced perfusion of the kidney.
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Incontinence-associated dermatitis (IAD) is predominantly a chemical irritation resulting from urine or stool coming in contact with the skin. Ammonia from urine and enzymes from stool can disrupt the acid mantle of the skin and eventually cause the skin to break down. As with the other forms of MASD discussed above, maceration also plays a key role in the formation of IAD, and can makes the skin more susceptible to friction damage.