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7 Hpw long would it take for (1) 81mg of aspirin to be completely out of your system...On for about 1 year. Dr. Venkata Chilakapati Dr. Chilakapati. Aspirin: For small dose of Aspirin elimination half life is 2 to 4.5 hours. So within 24 hours it will be completely eliminated from the body.
Depends on dosage-: Half-life = 2-3 hours for low dose, and about 30 hours for higher dosage. Because of the way it acts on your system, especially platelet, it exerts its effect for about 1 wk, hence you are often advised not to take aspirin/aspirin-related products for about 5-7 days before surgery.