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The drugâs initial approval noted mild side effects such as vomiting, itching, lethargy and diarrhea. Some 70 million doses of Trifexis have been distributed through 15,000 veterinary clinics, said Elanco spokeswoman Julie Lawless.
Trifexis is indicated for the prevention of heartworm disease and treat and control hookworms, roundworms and whipworms. Trifexis also kills fleas and is indicated for the treatment and prevention of flea infestations. Trifexis should be given according to your veterinarianâs instructions. It should be given orally once a month at the minimum dose of 13.5mg/lb spinosad and 0.2mg/lb milbemycin oxime body weight. For heartworm prevention, give once monthly for at least 3 months after exposure to mosquitoes.