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What year did Columbus sail? Christopher Columbus first sailed to find a western route to Asia in 1492. He left the Spanish port of Palos on Aug. 3 of that year with three ships: the Santa Maria, captained by Columbus himself, and the smaller Nina and Pinta, helmed by the Pinzon brothers.
Cite This Source. Christopher Columbus in The Columbian Exchange. Christopher Columbus (1451-1506) was a navigator and explorer whose famous 1492 voyage from Spain to the West Indies marked the beginning of successful European colonization of the Americas. On 12 October 1492, Columbus and his crews aboard the Nina, Pinta, and Santa Maria made landfall in the Bahamas.