The most common and severe form of Î±1-antitrypsin deficiency is caused by the Z mutation, a single base substitution (Gul342-Lys) in the Î±1-antitrypsin gene. Misfolding of proteins during synthesis can initiate an ordered polymerization, which leads to aggregation of the protein within the cell.
Main article: List of place names of Native American origin in California. 1  Malibu â from VentureÃ±o <Umalibu>, perhaps reflecting [(hu)maliwu], it (the surf) makes a loud noise all the time over there. 2  Pismo Beach - from Chumash Pismu for tar. 3  Simi Valley â from VentureÃ±o <Simiyi>.
Bigmeat House of Pottery, Cherokee. The Bigmeat name is synonymous with Cherokee pottery. Matriarch Charlotte Welch Bigmeat (1887-1959) was steeped in the pottery tradition. Each of her five daughtersâTiney, Ethel, Elizabeth, Mabel, and Louiseâbecame potters. The youngest Bigmeat daughter, Louise, together with her husband John Henry Maney, established the Bigmeat House of Pottery at the entrance to Painttown.