in the x direction, the water wants to flow in that direction) For a given hydraulic. conductivity, the vertical flow rate depends on the sum of the gravitational potential energy. gradient per unit weight of water (dz/dz =1) and the vertical gradient in soil water pressure.
Origin and spread of the 1278insTATC mutation causing TayâSachs disease in Ashkenazi Jews: Genetic drift as a robust and parsimonious hypothesis. Human Genetics 114 (4): 366â376. pmid 14727180.
Tay-Sachs disease is a gangliosidosis characterised by: An exaggerated startle response. Delay in psychomotor development. Hypotonia (followed by spasticity) Visual loss. A macular cherry-red spot. Pathogenesis. Tay-Sachs disease (and its variants) are caused by absence or defects of the alpha subunit of hexosaminidase A.