The most common and severe form of Î±1-antitrypsin deficiency is caused by the Z mutation, a single base substitution (Gul342-Lys) in the Î±1-antitrypsin gene. Misfolding of proteins during synthesis can initiate an ordered polymerization, which leads to aggregation of the protein within the cell.
Main article: List of place names of Native American origin in California. 1  Malibu â from VentureÃ±o <Umalibu>, perhaps reflecting [(hu)maliwu], it (the surf) makes a loud noise all the time over there. 2  Pismo Beach - from Chumash Pismu for tar. 3  Simi Valley â from VentureÃ±o <Simiyi>.
The city's name is most commonly attributed to Muskogee origin, Haiyakpo (prairie) and hili (pretty) combining in Hialeah to mean pretty prairie. Alternatively, the word is of Seminole origin meaning Upland Prairie. The city is located upon a large prairie between Biscayne Bay and the Everglades. Hialeah has the second highest percentage of Cuban and Cuban American residents of any city in the US. Hialeah is also the densest American city in terms of population not to feature a skyscraper.