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Causes of cardiovascular disease. While cardiovascular disease can refer to different heart or blood vessel problems, the term is often used to mean damage to your heart or blood vessels by atherosclerosis (ath-ur-o-skluh-ROE-sis), a buildup of fatty plaques in your arteries.
Coronary artery disease, also called coronary heart disease, or simply, heart disease, affects millions of Americans. This serious condition is a result of plaque buildup in your arteries. The arteries, which start out smooth and elastic, get plaque on their inner walls, which can make them more rigid and narrowed. This restricts blood flow to your heart, which can then become starved of oxygen. The plaque could rupture, leading to a heart attack or sudden cardiac death.