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Large red blood cells aka Macrocytosis is a common effect caused by Vitamin B12/Folate deficiency anemia.Common causes are a vegan diet, because Vitamin B12 comes from foods from animal origin.arge red blood cells aka Macrocytosis is a common effect caused by Vitamin B12/Folate deficiency anemia.
Quick Answer. According to the Mayo Clinic, enlarged red blood cells, or macrocytosis, is a non-specific medical condition that has a number of different causes. Among the most common are vitamin B12 deficiency, folate deficiency, alcoholism, hypothyroidism (under-active thyroid) and liver disease.