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1 Ibuprofen (MotrinÂ®, AdvilÂ®), naproxen (AleveÂ®) and aspirin are non-steroidal anti-inflammatory drugs, abbreviated NSAIDs. 2  They are available over-the-counter (OTC). 3  Other NSAIDs require a prescription. 4  NSAIDs are used to treat pain, fever, and inflammation.