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During the past 30 years, Î²-blockers have been used to treat hypertension, prevent myocardial infarction, and treat arrhythmias. 29, 30 Treatment with Î²-blockers for heart failure has been controversial because of the negative chronotropic and inotropic actions of these drugs. Recent studies 3, 6â , 9 indicated that Î²-blockers improve signs and symptoms, exercise tolerance, and hemodynamics and reduce mortality in patients with heart failure.