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Losartan can be administered once or twice daily at total daily doses of 25 to 100 mg. If the antihypertensive effect measured at trough using once-aday dosing is inadequate, a twice-a-day regimen at the same total daily dose or an increase in dose may give a more satisfactory response.
The maximum daily dose is 2 tablets per day of Losartan potassium / Hydrochlorothiazide 50 mg/12.5 mg Film-coated Tablets or 1 tablet daily of Losartan potassium / Hydrochlorothiazide 100 mg/25 mg Film-coated Tablets.he active substances are losartan potassium and hydrochlorothiazide. Losartan potassium / hydrochlorothiazide 50 mg/12.5 mg Film-coated Tablets. Each Tablet contains 50 mg of losartan potassium equivalent to 45.8 mg of losartan and 12.5 mg of hydrochlorothiazide.