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Losartan can be administered once or twice daily at total daily doses of 25 to 100 mg. If the antihypertensive effect measured at trough using once-aday dosing is inadequate, a twice-a-day regimen at the same total daily dose or an increase in dose may give a more satisfactory response.
The usual starting dosage of losartan potassium is 50 mg once daily. The dosage can be increased to a maximum of 100 mg daily. Doses exceeding 100 mg have not been found to produce any additional decrease in systolic or diastolic blood pressure.