B12 deficiency anemia may also be caused by a lack of intrinsic factor-pernicious anemia. The patient's digestive system cannot absorb B12 properly. Signs and symptoms of pernicious anemia may include: 1  Fatigue.2  Shortness of breath. 3  Palpitations.12 deficiency anemia may also be caused by a lack of intrinsic factor-pernicious anemia. The patient's digestive system cannot absorb B12 properly. Signs and symptoms of pernicious anemia may include: 1  Fatigue. 2  Shortness of breath.
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