The most common and severe form of Î±1-antitrypsin deficiency is caused by the Z mutation, a single base substitution (Gul342-Lys) in the Î±1-antitrypsin gene. Misfolding of proteins during synthesis can initiate an ordered polymerization, which leads to aggregation of the protein within the cell.
Main article: List of place names of Native American origin in California. 1  Malibu â from VentureÃ±o <Umalibu>, perhaps reflecting [(hu)maliwu], it (the surf) makes a loud noise all the time over there. 2  Pismo Beach - from Chumash Pismu for tar. 3  Simi Valley â from VentureÃ±o <Simiyi>.
It comes from the Shawnee word shawanwa, which means southerner. In history books, you can sometimes see the same name spelled Shawano or Sewanee. The original Shawnee hom â¦ e land was in Ohio, Kentucky, and Indiana. But the Shawnees were far-ranging people. Shawnee villages were located as far north as New York state and as far south as Georgia..