The most common and severe form of Î±1-antitrypsin deficiency is caused by the Z mutation, a single base substitution (Gul342-Lys) in the Î±1-antitrypsin gene. Misfolding of proteins during synthesis can initiate an ordered polymerization, which leads to aggregation of the protein within the cell.
Main article: List of place names of Native American origin in California. 1  Malibu â from VentureÃ±o <Umalibu>, perhaps reflecting [(hu)maliwu], it (the surf) makes a loud noise all the time over there. 2  Pismo Beach - from Chumash Pismu for tar. 3  Simi Valley â from VentureÃ±o <Simiyi>.
Native place-names abound: Skagway and Ketchikan (Tlingit), Kodiak and Katmai (Eskimo), and Alaska and Akutan (Aleut). In 2000, 85.7% of the population five years old and older was reported to speak only English in the home, a decrease over 87.9% recorded in 1990. The following table gives selected statistics from the 2000 census for language spoken at home by persons five years old and over. The category Other Native North American languages includes Apache, Cherokee, Choctaw, Dakota, Keres, Pima, and Yupik.