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So back to your question: 1  Your chest hurts when you're emotionally sad because your brain processes physical and social pain in the same brain regions (dACC and AI) (the affective aspects of the pain). The fact that both pains overlap means the factors that decrease physical pain also decrease emotional pain.
1 Costochondritis is a common cause of chest pain. It is caused by inflammation of the joints in the rib cage.  The symptoms of costochondritis include sharp chest pain, which feels worse when coughing, sneezing or breathing heavily, and tenderness or soreness of the rib cage.