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The dose (volume of injection in mL) per month = patient weight (kg) x 15 mg per kg Ã· 100 mg per mL of Synagis. Injection volumes over 1 mL should be. given as a divided dose. â¢ Synagis is supplied as a single-dose vial and does not contain preservatives.
Use clinical response and laboratory tests to guide dosage calculations.1 (See Laboratory Monitoring under Cautions.) Determine preinfusion (baseline) antithrombin III concentration and calculate initial (loading) dosage using following formula:1 4. Initial Dose (units) = (desired antithrombin III concentration - baseline antithrombin III concentration [% of normal] Ã wt (in kg) Ã· 1.4.