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Manganese is a part of many enzyme systems, including the enzymes involved in blood sugar control, energy metabolism, and thyroid hormone function. Manganese also participates in the antioxidant enzyme, superoxide dismutase, or SOD.
Similarly, the maintenance of proper manganese levels is important for normal brain functioning. Several in vivo and in vitro studies have linked increased manganese concentrations with alterations in the content and metabolism of neurotransmitters, namely dopamine, Î³-aminobutyric acid, and glutamate.rikson, K.M., Aschner, M., 2002. Manganese causes differential regulation of glutamate transporter (GLAST), taurine transporter, and metallothionein in cultured rat astrocytes. Neurotoxicology 23, 595â 602.