Post differentials. (a). A post differential may be granted on the basis of conditions of environment which differ substantially from conditions of environment in the continental United States and warrant additional pay as a recruitment and retention incentive.
We will also see that in order for a neuron to generate an action potential, the membrane potential has to depolarize from the resting value of around â70 mV to the threshold value of around â50 mV. A similar situation is also at play in muscle cells (skeletal, cardiac, and smooth).
In normal skeletal muscle, Cl â fluxes account for 70â80% of the resting membrane conductance. With defective Cl â channels and smaller Cl â influxes, smaller influxes of Na + are needed to reach threshold and trigger action potentials, and thus muscle excitability is enhanced (1) (Fig. 4).ifferent types of delayed rectifier K + channels are found in vertebrate nerves, the heart, and skeletal muscle, and they are encoded by different genes (9). Loss of function mutations (mutations that cause channels to conduct fewer ions) in voltage-gated K + channels prolong the duration of the action potential (2).