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When someone gets HIV, the body's immune system makes antibodies to try to fight the infection. Most HIV tests available today test for HIV antibodies. If HIV antibodies are present, it means that a person is infected with HIV. One type of HIV test detects the virus itself. This is called an RNA test. RNA testing is more expensive and much less common than antibody tests.
ELISA is the most commonly used type of test to screen for HIV infection because of its relatively simple methodology, inherent high sensitivity, and suitability for testing large numbers of samples, particularly in blood testing centers.