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Ibuprofen is a non-steroid drug often used to treat arthritis and relieve pain, fever, and swelling. Its development resulted from a search to find a drug more potent (powerful) and better tolerated than aspirin. When ibuprofen was approved for over-the-counter (OTC) use in the United States in May 1984, it was the first new OTC pain relief medication to enter the marketplace in a generation.