The most common and severe form of Î±1-antitrypsin deficiency is caused by the Z mutation, a single base substitution (Gul342-Lys) in the Î±1-antitrypsin gene. Misfolding of proteins during synthesis can initiate an ordered polymerization, which leads to aggregation of the protein within the cell.
Main article: List of place names of Native American origin in California. 1  Malibu â from VentureÃ±o <Umalibu>, perhaps reflecting [(hu)maliwu], it (the surf) makes a loud noise all the time over there. 2  Pismo Beach - from Chumash Pismu for tar. 3  Simi Valley â from VentureÃ±o <Simiyi>.
The prominent he Indian tribes in the area were the Tipai-Ipai. The native term most frequently used for the San Diego natives is Kumeyaay, one of the principal dialects. The Spanish called the neophytes at Mission San Diego DiegueÃ±o. Unlike other missios, the neophytes at San Diego continued to reside in traditional villages in part due to food shortages at the mission.