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7 Hpw long would it take for (1) 81mg of aspirin to be completely out of your system...On for about 1 year. Dr. Venkata Chilakapati Dr. Chilakapati. Aspirin: For small dose of Aspirin elimination half life is 2 to 4.5 hours. So within 24 hours it will be completely eliminated from the body.
Aspirin does not have a â24-hour half-lifeâ â itâs much shorter than that. Depending on the amount ingested, the time required for the drugâs activity to lose half its initial effectiveness ranges from just over 3 hours for a 300-650 mg dose to 5 hours for a 1 g dose and 9 hours for a 2 g dose.