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When someone gets HIV, the body's immune system makes antibodies to try to fight the infection. Most HIV tests available today test for HIV antibodies. If HIV antibodies are present, it means that a person is infected with HIV. One type of HIV test detects the virus itself. This is called an RNA test. RNA testing is more expensive and much less common than antibody tests.
All previously approved HIV tests use either blood or oral fluid samples. The new urine-based test detects the presence of antibodies to HIV-1, the virus that causes the vast majority of U.S. AIDS cases, using an enzyme linked immunosorbent assay (ELISA) method.