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nephrosclerosis nephÂ·roÂ·scleÂ·roÂ·sis (nÄf'rÅ-sklÉ-rÅ'sÄ­s) n. Induration of the kidney from overgrowth and contraction of the interstitial connective tissue.
Nephrosis (nef-RO-sis), or nephrotic syndrome, is a kidney disease that causes the body to lose protein through the urine. Loss of protein results in edema, loss of appetite, and general tiredness. Nephrosis cannot usually be cured, but it can be treated with medication and diet.