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Meatloaf is done when a meat thermometer inserted in its center reads 160 degrees Fahrenheit. Ground beef used for food items like hamburgers or meatloaf should be at this temperature after it is cooked.
You should bake meatloaf at 350 degrees F for 30-40- minutes per pound if cooked in a bread pan. If cooked in a shallow pan, it won't take as long for the center to get done.The temperature of a meatloaf when done should be 160 degrees F when checked with a probe. typical two pound meatloaf should be covered in foil. Preheat  oven at 375 degrees and back for 80 minutes. Next remove the foil  and cook at 375 for another 15 minutes.