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Causes of sepsis. Sepsis can be triggered by an infection in any part of the body. The most common sites of infection leading to sepsis are the lungs, urinary tract, tummy (abdomen) and pelvis. Sepsis may develop when you're already in hospital. For example, you're more likely to develop sepsis if:
Sepsis, also known as systemic inflammatory response syndrome (SIRS), is a serious medical condition caused by the bodyâs response to an infection. Sepsis can lead to widespread inflammation and blood clotting. Inflammation may result in redness, heat, swelling, pain, and organ dysfunction or failure.ommon sites and types of infection that can lead to sepsis include: 1  The abdomen âAn inflammation of the appendix (appendicitis), bowel problems, infection of the abdominal cavity (peritonitis), and gallbladder or liver infections.