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Medical Definition of Immunosuppression. Immunosuppression: Suppression of the immune system and its ability to fight infection. Immunosuppression may result from certain diseases, such as AIDS or lymphoma, or from certain drugs, such as some of those used to treat cancer. Immunosuppression may also be deliberately induced with drugs, as in preparation for bone marrow or other organ transplantation, to prevent the rejection of a transplant.
Overview of Immunosuppressant Drugs. Immunosuppressant drugs are a class of drugs that suppress or reduce the strength of the bodyâs immune system. They are also called anti-rejection drugs.One of the primary uses of immunosuppressant drugs is to lower the bodyâs ability to reject a transplanted organ, such as a liver, heart or kidney.y suppressing this reaction, immunosuppressant drugs can help control the impact of the disease on the body. Other diseases treated with immunosuppressant drugs include: 1  psoriasis. 2  rheumatoid arthritis. 3  Crohnâs disease, a chronic inflammation of the digestive tract. 4  multiple sclerosis.