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The worst type of liver disease is cirrhosis of the liver, which replaces healthy cells with scar tissue. Cirrhosis has different causes such as hepatitis types B, C and D; prolonged heavy drinking...
Frankly I think Hungtington's disease is one of the saddest diseases because you're fully conscious you will inevitably suffer from it and die a slow and terrible death. It's also sad that most people that discover they have this disease already had children. You could play russian roulette with which child inherited the disease. Other terrible diseases would be Lou Gherigs disease, multiple sclerosis and Parkinsons. They are all slow, fatal and you're conscious about everything.