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In the brain, dopamine functions as a neurotransmitter âa chemical released by nerve cells to send signals to other nerve cells. The brain includes several distinct dopamine systems, one of which plays a major role in reward-motivated behavior.
Summary. By altering neurotransmission, addictive drugs produce effects that make people want to continue to abuse them and induce health problems that can be longlasting and profound. The effects are drug-specific: Each drug disrupts particular neurotransmitters in particular ways. Some important effects, however, are shared by all: initial pleasurable feelings, and subsequent dependence and addiction, resulting from disruption of the dopamine neurotransmitter system.