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These medicines may include: 1  Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, indomethacin, or naproxen. 2  Do not take aspirin, which should never be used to relieve pain during a gout attack. 3  Aspirin may change uric acid levels in the blood and may make the attack worse. 4  Be safe with medicines.his can reduce how often you have gout attacks and how severe they are. These medicines may include: 1  Uricosuric agents, to increase elimination of uric acid by the kidneys. 2  Xanthine oxidase inhibitors, to decrease production of uric acid by the body.
The gout medicine âAllopurinolâ is the oldest and most widely used gout medication in the world today. It works in the body by mimicking hypoxanthine (a type of purine) because it has the exact same structure as hypoxanthine.