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Causes of sepsis. Sepsis can be triggered by an infection in any part of the body. The most common sites of infection leading to sepsis are the lungs, urinary tract, tummy (abdomen) and pelvis. Sepsis may develop when you're already in hospital. For example, you're more likely to develop sepsis if:
Sepsis is caused by your bodyâs defense system (immune system) working overtime to fight infection. Itâs sometimes called septicemia. The large number of chemicals released into the blood during this process triggers widespread inflammation. This can lead to organ damage.