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p53, also known as TP53 or tumor protein (EC :2.7.1.37) is a gene that codes for a protein that regulates the cell cycle and hence functions as a tumor suppression.It is very important for cells in multicellular organisms to suppress cancer.53 has been described as the guardian of the genome, referring to its role in conserving stability by preventing genome mutation (Strachan and Read, 1999). The name is due to its molecular mass: it is in the 53 kilodalton fraction of cell proteins.
The level of p53 protein is regulatedthrough the cell cycle by two mechanisms: (i) p53 RNA transcription increases by 10- to 20-fold late in the G1phase(3, 4) and (ii) normal p53 protein is rapidly eliminated byvirtue of its short half-life (6-30 min) (5-7).n general, mu-tant forms of the p53 protein that are transforming haveseveral properties that distinguish them from wild type.They fail to bind to the simian virus 40tumor antigen (10) but doform stable complexes with hsc70 (11), a constitutivelyexpressed member of the heat shock family.