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Meatloaf is done when a meat thermometer inserted in its center reads 160 degrees Fahrenheit. Ground beef used for food items like hamburgers or meatloaf should be at this temperature after it is cooked.
A meatloaf needs to reach an internal temperature of 160 degrees Fahrenheit before it can be safely consumed. The best method to check the internal temperature of meatloaf and other meats is using a meat thermometer.