Other signs and symptoms of HIV infection include: 1  genital ulcers. 2  genital warts. 3  severe mucosal herpes infections.
1 Pain, swelling, redness, and warmth that develop suddenly in a big toe joint may be caused by gout. 2  Other conditions or diseases that may cause inflammation include: 3  Arthritis or rheumatic diseases. 4  Retrocalcaneal bursitis and tendinitis, which can occur from overuse injuries.
Injury to the Feet and Ankles. Another cause of foot and ankle swelling is injury or trauma to the feet. When the tissues and muscles of the feet and ankles are strained or damaged, they will become inflamed and fill with blood, causing swelling. A sprained ankle, foot, or broken bone in the foot will usually cause a large amount of swelling, especially in the days immediately following the injury.