Other signs and symptoms of HIV infection include: 1  genital ulcers. 2  genital warts. 3  severe mucosal herpes infections.
1 Pain, swelling, redness, and warmth that develop suddenly in a big toe joint may be caused by gout. 2  Other conditions or diseases that may cause inflammation include: 3  Arthritis or rheumatic diseases. 4  Retrocalcaneal bursitis and tendinitis, which can occur from overuse injuries.
Infectious causes of ankle lumps or swelling include viral and bacterial infections. Left untreated, some of these diseases can lead to serious complications and secondary illnesses. Infections that cause ankle lumps include: 1  Abscesses.