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nephrosclerosis nephÂ·roÂ·scleÂ·roÂ·sis (nÄf'rÅ-sklÉ-rÅ'sÄ­s) n. Induration of the kidney from overgrowth and contraction of the interstitial connective tissue.
Establishment of an opening between the pelvis of the kidney through its cortex to the exterior of the body. nephrostomy. An opening into the kidney for the purpose of draining urine by way of a tube.