Other signs and symptoms of HIV infection include: 1  genital ulcers. 2  genital warts. 3  severe mucosal herpes infections.
1 Pain, swelling, redness, and warmth that develop suddenly in a big toe joint may be caused by gout. 2  Other conditions or diseases that may cause inflammation include: 3  Arthritis or rheumatic diseases. 4  Retrocalcaneal bursitis and tendinitis, which can occur from overuse injuries.
Arthritis, or joint inflammation, can cause localized swelling in the foot or ankle. Osteoarthritis is a common form of arthritis that may cause occasional swelling, usually in a single joint. Gout is another form of arthritis that typically causes a very painful, red, swollen big toe joint. Gout can also affect the ankle. Some autoimmune diseases cause swelling and arthritis that affect both feet equally, such as rheumatoid arthritis, psoriatic arthritis, lupus, and reactive arthritis (Reiter's syndrome).