Chest pain and shortness of breath if blood clots form in the blood vessels in your lungs and heart. Pain, redness, warmth, and swelling in the lower leg if blood clots form in the deep veins of your leg. Headaches, speech changes, paralysis (an inability to move), dizziness, and trouble speaking and understanding if blood clots form in the blood vessels in your brain. These signs and symptoms may indicate a stroke.
From Wikipedia, the free encyclopedia. A gene knockout (abbreviation: KO) is a genetic technique in which one of an organism 's genes is made inoperative (knocked out of the organism). knockout mouse (left) that is a model of obesity, compared with a normal mouse. A conditional knockout allows gene deletion in a tissue or time specific manner. This is done by introducing short sequences called loxP sites around the gene.
2. ES cells containing a knockout mutation in one allele of the gene being studied are introduced into early mouse embryos. The resultant mice will be chimeras containing tissues derived from both the transplanted ES cells and the host cells.These cells can contribute to both the germ-cell and somatic-cell populations.ene knockout is a technique for selectively inactivating a gene by replacing it with a mutant allele in an otherwise normal organism. This technique of disrupting gene function, which has been widely used in yeast and mice, is a powerful tool for unraveling the mechanisms by which basic cellular processes occur.