Other signs and symptoms of HIV infection include: 1  genital ulcers. 2  genital warts. 3  severe mucosal herpes infections.
1 Pain, swelling, redness, and warmth that develop suddenly in a big toe joint may be caused by gout. 2  Other conditions or diseases that may cause inflammation include: 3  Arthritis or rheumatic diseases. 4  Retrocalcaneal bursitis and tendinitis, which can occur from overuse injuries.
Pain and swelling that occur without an injury and with redness, red streaking, tenderness, heat, fever, or pus may be caused by an infection. Infections can occur without a known injury to the affected area. Pain, swelling, redness, and warmth that develop suddenly in a big toe joint may be caused by gout.