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The aging process is associated with changes in the composition and function of the immune system and these changes may occur at an accelerated rate in men as compared to women. Moreover, after the age of menopause, the incidence of chronic inflammatory disease in women approaches or exceeds that observed in males.he mechanisms responsible for sex-specific differences in the immune response are complex and likely involve effects of the sex hormones on the immune system, genetic factors, and gender-specific behaviors and exposures.
Immune Senescence. Immune senescence, or the aging of the immune system, particularly its effect on changes in lymphocyte development and function, predisposes older adults to a higher risk of latent virus reactivation.ge-related immune senescent remodeling likely involves both the innate and adaptive immune system and may contribute to the immune systemâs functional decline; chronic inflammatory state; and risk for frailty, chronic disease, and functional decline in older adults.