A guarantee of a person's signature is required by all Transfer Agents, under SEC Rule 17Ad-15, before a security transfer can take place. The organization that guarantees the authenticity of the signature is liable for the financial value of the transaction.
p53, also known as TP53 or tumor protein (EC :2.7.1.37) is a gene that codes for a protein that regulates the cell cycle and hence functions as a tumor suppression.It is very important for cells in multicellular organisms to suppress cancer.53 has been described as the guardian of the genome, referring to its role in conserving stability by preventing genome mutation (Strachan and Read, 1999). The name is due to its molecular mass: it is in the 53 kilodalton fraction of cell proteins.
LincRNA p21 is an example of lncRNAs that are involved in DNA damage and cell cycle control. p53-regulated lincRNA p21 expression plays an important role in triggering apoptosis. LincRNA p21 can bind to heterogeneous nuclear ribonucleoprotein K (hnRNP-K), which is a coactivator of p53-dependent p21 transcription.nterestingly, a bidirectional regulatory pathway exists between non-coding RNAs and DDR. In response to DNA damage, non-coding RNAs can directly regulate cellular processes involved in DDR by altering their targeting genes, which provides a feedback regulatory loop for non-coding RNA-mediated DDR.