Other signs and symptoms of HIV infection include: 1  genital ulcers. 2  genital warts. 3  severe mucosal herpes infections.
1 Pain, swelling, redness, and warmth that develop suddenly in a big toe joint may be caused by gout. 2  Other conditions or diseases that may cause inflammation include: 3  Arthritis or rheumatic diseases. 4  Retrocalcaneal bursitis and tendinitis, which can occur from overuse injuries.
The most common form of arthritis that affects the big toe joint is osteoarthritis, caused by wear-and-tearâwith typical symptoms of joint pain and stiffness. Osteoarthritis at the big toe joint may develop from problems with foot structure and functioning, resulting in excess wear-and-tear.