A guarantee of a person's signature is required by all Transfer Agents, under SEC Rule 17Ad-15, before a security transfer can take place. The organization that guarantees the authenticity of the signature is liable for the financial value of the transaction.
p53, also known as TP53 or tumor protein (EC :2.7.1.37) is a gene that codes for a protein that regulates the cell cycle and hence functions as a tumor suppression.It is very important for cells in multicellular organisms to suppress cancer.53 has been described as the guardian of the genome, referring to its role in conserving stability by preventing genome mutation (Strachan and Read, 1999). The name is due to its molecular mass: it is in the 53 kilodalton fraction of cell proteins.
The p53 protein plays an integral role in the cell and is normally present in all cell types. The protein is localized in the nucleus where it functions as a transcription factor. The p53 protein is at the center of a large network of proteins that 'sense' the health of a cell and cellular DNA.hen damage is sensed, the activity of the p53 protein aids in the decision between repair and the induction of cell death (apoptosis). As a transcription factor, p53 stimulates the transcription of a group of target genes. Among them, p21 is one of the most important.