1 The gum disease of gingivitis is an infection that occurs when bacteria invade soft tissues and bone adjacent to teeth. 2  The severity of this infection varies from mild to severe and can be an indication of a life-threatening systemic disease.
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Valsartan (Figure 1) is a member of a class of compounds known as angiotensin II (AT-II) receptor antagonists. This class combines effective anti-hypertensive activity with an excellent profile of safety and tolerability.he reaction mixture was heated to reflux at 75 Â°C for 2 h. The reaction was monitored by TLC until the starting material was consumed. Water (30 mL) was added to the reaction mixture and extracted with ethyl acetate (3 Ã 50 mL). The ethyl acetate layer was separated and concentrated under vacuum.