Other signs and symptoms of HIV infection include: 1  genital ulcers. 2  genital warts. 3  severe mucosal herpes infections.
1 Pain, swelling, redness, and warmth that develop suddenly in a big toe joint may be caused by gout. 2  Other conditions or diseases that may cause inflammation include: 3  Arthritis or rheumatic diseases. 4  Retrocalcaneal bursitis and tendinitis, which can occur from overuse injuries.
Injury and Overuse. Injury of any of the leg structures is a leading cause of acute inflammation and swelling. With the leg muscles and tendons, overuse may also cause inflammation. Swelling of the more superficial muscles at the back of the lower leg â gastrocnemius or soleus â is more likely to contribute to visible swelling.