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Medical Definition of Immunosuppression. Immunosuppression: Suppression of the immune system and its ability to fight infection. Immunosuppression may result from certain diseases, such as AIDS or lymphoma, or from certain drugs, such as some of those used to treat cancer. Immunosuppression may also be deliberately induced with drugs, as in preparation for bone marrow or other organ transplantation, to prevent the rejection of a transplant.
Immunosuppressant: An agent that can suppress or prevent  the immune response. Immunosuppressants are used to prevent  rejection of a transplanted organ and to treat autoimm â¦ une diseases  such as  psoriasis,rheumatoid  arthritis, and  Crohn's disease. Some treatments for  cancer act as immunosuppressants.