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The aim of Bertoli was to determine the long-term effects of a ketogenic diet on body composition and bone mineral status of patients with GLUT-1 DS. Changes in body composition and bone mineral status were observed in adult patients with GLUT-1 DS who have been treated with a ketogenic diet for more than 5 years.
During prolonged fasting or starvation, or as the intentional result of a ketogenic diet, acetyl-CoA in the liver is used to produce ketone bodies instead, leading to a state of ketosis. During starvation or a long physical training session, the body starts using fatty acids instead of glucose. The brain cannot use long-chain fatty acids for energy because they are completely albumin-bound and cannot cross the bloodâbrain barrier. Not all medium-chain fatty acids are bound to albumin.