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1 People often experience an upset stomach, diarrhea (possibly bloody), abdominal pain and painful swallowing when using aspartame as a sweetener.  Skin and Allergies. Hives and intense itching, lip or mouth swelling and worsening of asthma all can occur due to aspartame.
The two amino acids making up 90 percent of aspartame are neurotoxins/excitotoxins in large enough doses, which themselves can cause problems with the nervous system. But the most harmful constituent of aspartame may be the 10 percent of the product that binds the two amino acids together -- methanol (wood alcohol).