1 The infection can be spread by saliva, and the incubation period for mono is four to eight weeks. 2  Most adults have laboratory evidence (antibodies against the EBV) indicative of a previous infection with EBV and are immune to further infection. 3  The symptoms of mono include: 4  fever, 5  fatigue, 6  sore throat, and. The symptoms of mono include: 2  fever, 3  fatigue, 4  sore throat, and. 5  swollen lymph nodes. 6  The diagnosis of mono is confirmed by blood tests.
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