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In the brain, dopamine functions as a neurotransmitter âa chemical released by nerve cells to send signals to other nerve cells. The brain includes several distinct dopamine systems, one of which plays a major role in reward-motivated behavior.
Effects of MDMA on the Brain. MDMA appears to have several effects on the brain. MDMA can: 1  cause the release of the neurotransmitter called serotonin. 2  block the reuptake of serotonin by the synaptic terminal that releases it.3  deplete the amount of serotonin in the brain.pecifically, the drug damaged cells that release the neurotransmitter called serotonin. Using an imaging technique called positron emission tomography (PET), Ricaurte noted a 20-60% reduction in healthy serotonin cells in the drug users. Damage to these cells could affect a person's abilities to remember and to learn.