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Meatloaf is done when a meat thermometer inserted in its center reads 160 degrees Fahrenheit. Ground beef used for food items like hamburgers or meatloaf should be at this temperature after it is cooked.
Preparation. 1  Heat oven to 350Â°F. 2  Combine all ingredients in large bowl; mix lightly but thoroughly. 3  Bake 50 to 55 minutes or until meatloaf is to medium doneness (160Â°F for beef, 170Â°F for turkey), until not pink in center and juices show no pink color.dvertisements. 1  Heat oven to 350Â°F. 2  Combine all ingredients in large bowl; mix lightly but thoroughly. 3  Bake 50 to 55 minutes or until meatloaf is to medium doneness (160Â°F for beef, 170Â°F for turkey), until not pink in center and juices show no pink color.