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1 People often experience an upset stomach, diarrhea (possibly bloody), abdominal pain and painful swallowing when using aspartame as a sweetener.  Skin and Allergies. Hives and intense itching, lip or mouth swelling and worsening of asthma all can occur due to aspartame.
Abdominal obesity; Insulin resistance; Impaired glucose intolerance; Abnormally elevated fats in the blood; High blood pressure; The study found drinking aspartame-sweetened diet soda daily increased the risk of type 2 diabetes by 67 percent (regardless of whether they gained weight or not) and the risk of metabolic syndrome 36 percent.