Other signs and symptoms of HIV infection include: 1  genital ulcers. 2  genital warts. 3  severe mucosal herpes infections.
1 Pain, swelling, redness, and warmth that develop suddenly in a big toe joint may be caused by gout. 2  Other conditions or diseases that may cause inflammation include: 3  Arthritis or rheumatic diseases. 4  Retrocalcaneal bursitis and tendinitis, which can occur from overuse injuries.
Inflammation due to acute or chronic injury can also cause a swollen ankle or leg. Conditions that can cause this type of inflammation include: ankle sprain; osteoarthritis; gout; broken leg; Achilles tendon rupture; ACL tear; Edema. Edema is a type of swelling that occurs when extra fluid flows into certain areas of your body. It usually affects the: legs; arms; hands