Other signs and symptoms of HIV infection include: 1  genital ulcers. 2  genital warts. 3  severe mucosal herpes infections.
1 Pain, swelling, redness, and warmth that develop suddenly in a big toe joint may be caused by gout. 2  Other conditions or diseases that may cause inflammation include: 3  Arthritis or rheumatic diseases. 4  Retrocalcaneal bursitis and tendinitis, which can occur from overuse injuries.
Arthritis, or joint inflammation, can cause localized swelling in the foot or ankle. Osteoarthritis is a common form of arthritis that may cause occasional swelling, usually in a single joint. Gout is another form of arthritis that typically causes a very painful, red, swollen big toe joint. Gout can also affect the ankle.