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Meatloaf is done when a meat thermometer inserted in its center reads 160 degrees Fahrenheit. Ground beef used for food items like hamburgers or meatloaf should be at this temperature after it is cooked.
Making Basic Meatloaf. 1  1. Preheat your oven to 350 degrees Fahrenheit. It's best to preheat the oven, because then your oven will be ready to go when you've finished putting the ingredients together and it will take less time to cook. 2  2. Mix bread pieces, onion, salt and pepper.