Alleles for a particular phenotype determine what characteristic an organism will express, as with the following example where. 1  Chromosome 1 contains an allele for blonde hair. 2  Chromosome 2 contains an allele for brown hair. 3  Chromosome 3 contains an allele for blue eyes. 4  Chromosome 4 contains an allele for brown eyes.
Because of the patient's smoking history and abnormal chest radiograph, a neoplasm was initially suspected as a cause of SIADH. The head trauma was too remote to be of concern. Although 1 case of risperidone-associated hyponatremia has been reported, the risk seems low with this agent and with olanzapine.
Although it is possible that hydrochlorothiazide could cause hyponatremia, it is striking that only one day after the addition of valproic acid symptoms occur. No further details were reported. Conclusion In the Lareb database 359 reports of valproic acid are present, of which six concern hyponatremia and/or SIADH. The number of reports in the Lareb and the WHO database and the case reports in literature support the association.