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Causes of sepsis. Sepsis can be triggered by an infection in any part of the body. The most common sites of infection leading to sepsis are the lungs, urinary tract, tummy (abdomen) and pelvis. Sepsis may develop when you're already in hospital. For example, you're more likely to develop sepsis if:
Many types of microbes can cause sepsis, including bacteria, fungi, and viruses. However, bacteria are the most common cause. In many cases, doctors cannot identify the source of infection. Severe cases of sepsis often result from a body-wide infection that spreads through the bloodstream.