A guarantee of a person's signature is required by all Transfer Agents, under SEC Rule 17Ad-15, before a security transfer can take place. The organization that guarantees the authenticity of the signature is liable for the financial value of the transaction.
p53, also known as TP53 or tumor protein (EC :2.7.1.37) is a gene that codes for a protein that regulates the cell cycle and hence functions as a tumor suppression.It is very important for cells in multicellular organisms to suppress cancer.53 has been described as the guardian of the genome, referring to its role in conserving stability by preventing genome mutation (Strachan and Read, 1999). The name is due to its molecular mass: it is in the 53 kilodalton fraction of cell proteins.
Other mutations delete small amounts of DNA from the gene. Mutations in the TP53 gene lead to a version of p53 that cannot regulate cell growth and division effectively. Specifically, the altered protein is unable to trigger apoptosis in cells with mutated or damaged DNA.As a result, DNA damage can accumulate in cells.his protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing too fast or in an uncontrolled way. The p53 protein is located in the nucleus of cells throughout the body, where it attaches (binds) directly to DNA.