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The aim of Bertoli was to determine the long-term effects of a ketogenic diet on body composition and bone mineral status of patients with GLUT-1 DS. Changes in body composition and bone mineral status were observed in adult patients with GLUT-1 DS who have been treated with a ketogenic diet for more than 5 years.
During the 1920s and 1930s, when the ketogenic diet was one of the most popular anticonvulsant therapies, side effects such as acidosis (low bicarbonate levels in the blood), constipation, and abnormal menstrual periods (in adult women) were discussed and were just starting to be investigated.