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Causes of sepsis. Sepsis can be triggered by an infection in any part of the body. The most common sites of infection leading to sepsis are the lungs, urinary tract, tummy (abdomen) and pelvis. Sepsis may develop when you're already in hospital. For example, you're more likely to develop sepsis if:
While we still donât know why our bodies react this way, we know that sepsis can cause: 1  Leakage from the lining blood vessel linings (much like a water hose with holes in it) 2  Low blood pressure (hypotension) with reduced blood flow to vital organs. 3  Small clots throughout the body that prevent nutrients from reaching vital organs.