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The Pre-Columbian era incorporates all period subdivisions in the history and prehistory of the Americas before the appearance of significant European influences on the American continents, spanning the time of the original settlement in the Upper Paleolithic period to European colonization during the Early Modern period. While the phrase pre-Columbian era literally refers only to the time preceding Christopher Columbus's voyages of 1492, in practice the phrase is usually used to denote the en
The Inca Empire was the largest empire in pre-Columbian America. This ran from approximately 1438 to 1533. Spanish conquistadors led by Francisco Pizarro explored south from what is today Panama, reaching Inca territory by 1526. Also Inca civil war between the two brothers led to their decline.