Other signs and symptoms of HIV infection include: 1  genital ulcers. 2  genital warts. 3  severe mucosal herpes infections.
1 Pain, swelling, redness, and warmth that develop suddenly in a big toe joint may be caused by gout. 2  Other conditions or diseases that may cause inflammation include: 3  Arthritis or rheumatic diseases. 4  Retrocalcaneal bursitis and tendinitis, which can occur from overuse injuries.
Excessive pronation (rolling in) as increased pressure is put on the balls of the feet. Injury to the ball of the foot, multiple surgery incisions or fractures can lead to thinning and displacement of the fat pad. Genetics are considered to be a cause behind excessive loss of fat pads on feet. Rheumatoid arthritis, which causes clawing of the toes and more prominent bones in the balls of the feet.