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Meatloaf is done when a meat thermometer inserted in its center reads 160 degrees Fahrenheit. Ground beef used for food items like hamburgers or meatloaf should be at this temperature after it is cooked.
1 Increase oven temperature to 400 degrees F (200 degrees C), and continue baking 15 minutes, to an internal temperature of 160 degrees F (70 degrees C). 2  In a small bowl, mix the remaining tomato sauce and ketchup. 3  Pour over the top of the meatloaf, and continue baking 10 minutes.