Fatigue may be related to: 1  Use of alcohol or drugs. 2  Excess physical activity. 3  Jet lag.  Lack of physical 1  activity. Lack of sleep.  Medications, such as antihistamines, cough 1  medicines. Unhealthy eating habits.
A directive shall be binding, as to the result to be achieved, upon each Member State to which it is addressed, but shall leave to the national authorities the choice of form and methods. A decision shall be binding in its entirety upon those to whom it is addressed.
For other uses, see Regulation (disambiguation). Regulation is an abstract concept of management of complex systems according to a set of rules and trends. In systems theory, these types of rules exist in various fields of biology and society, but the term has slightly different meanings according to context. For example: