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Meatloaf is done when a meat thermometer inserted in its center reads 160 degrees Fahrenheit. Ground beef used for food items like hamburgers or meatloaf should be at this temperature after it is cooked.
Step 7. Photo Credit Dyana Rzentkowski/Demand Media. Bake the meatloaf at 350 degrees Fahrenheit for around an hour or until the temperature of the loaf's center is approximately 160 F when tested with a meat thermometer. Allow the loaf to stand for 10 to 15 minutes before slicing and serving it.