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1 People often experience an upset stomach, diarrhea (possibly bloody), abdominal pain and painful swallowing when using aspartame as a sweetener.  Skin and Allergies. Hives and intense itching, lip or mouth swelling and worsening of asthma all can occur due to aspartame.
Story at-a-glance -. While manufacturers of artificial sweeteners claim that their products are safe, these are actually linked to many side effects. Aspartame goes by the brand names NutraSweet and Equal and is 180 times as sweet as sugar. At the end of 2008, aspartame was found in over 6,000 products.