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1 People often experience an upset stomach, diarrhea (possibly bloody), abdominal pain and painful swallowing when using aspartame as a sweetener.  Skin and Allergies. Hives and intense itching, lip or mouth swelling and worsening of asthma all can occur due to aspartame.
Which Diet Drinks Do Not Contain Aspartame? Aspartame, one of the most common artificial sweeteners found in diet drinks, has been accused of a long list of side effects. Headaches, abdominal pain, fatigue, and change in heart rate are some of the reactions associated with consuming aspartame.