Other signs and symptoms of HIV infection include: 1  genital ulcers. 2  genital warts. 3  severe mucosal herpes infections.
1 Pain, swelling, redness, and warmth that develop suddenly in a big toe joint may be caused by gout. 2  Other conditions or diseases that may cause inflammation include: 3  Arthritis or rheumatic diseases. 4  Retrocalcaneal bursitis and tendinitis, which can occur from overuse injuries.
Gout (also known as podagra when it involves the big toe) is a medical condition usually characterized by recurrent attacks of acute inflammatory arthritis âa red, tender, hot, swollen joint. The metatarsal-phalangeal joint at the base of the big toe is the most commonly affected (approximately 50% of cases).