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The four most common teratogens are  tobacco, alcohol, medications and illegal drugs. Teratogens are substances that could harm a developing fetus by affecting growth and causing birth defects or death.
These can be thought of as the old-fashioned group of antihistamines. Diphenhydramine (Benadryl) is one of the most common first generation H1-receptor blockers. Other examples include clemastine (Tavist), dimenhydrinate (Dramamine), promethazine (Phenergan) and hydroxyzine (Vistaril, Atarax).