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Meatloaf is done when a meat thermometer inserted in its center reads 160 degrees Fahrenheit. Ground beef used for food items like hamburgers or meatloaf should be at this temperature after it is cooked.
A 2-pound meatloaf will reliably cook in about an hour â try not to overcook or the meat will start getting tough and crumbly. The best way to know when a meatloaf is done is by checking its internal temperature; as soon as it hits 155Â°F, you can pull it from the oven.