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These medicines may include: 1  Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, indomethacin, or naproxen. 2  Do not take aspirin, which should never be used to relieve pain during a gout attack. 3  Aspirin may change uric acid levels in the blood and may make the attack worse. 4  Be safe with medicines.his can reduce how often you have gout attacks and how severe they are. These medicines may include: 1  Uricosuric agents, to increase elimination of uric acid by the kidneys. 2  Xanthine oxidase inhibitors, to decrease production of uric acid by the body.
Colchicine is a medication most commonly used to treat gout. It is a toxic natural product and secondary metabolite, originally extracted from plants of the genus Colchicum (autumn crocus, Colchicum autumnale, also known as meadow saffron).Adverse effects are primarily gastrointestinal upset at high doses.olchicine is an alternative for those unable to tolerate NSAIDs in gout. At high doses, side effects (primarily gastrointestinal upset) limit its use. At lower doses, which are still effective, it is well tolerated.