Other signs and symptoms of HIV infection include: 1  genital ulcers. 2  genital warts. 3  severe mucosal herpes infections.
1 Pain, swelling, redness, and warmth that develop suddenly in a big toe joint may be caused by gout. 2  Other conditions or diseases that may cause inflammation include: 3  Arthritis or rheumatic diseases. 4  Retrocalcaneal bursitis and tendinitis, which can occur from overuse injuries.
Juvenile arthritis, a term used when arthritis begins before age 16, can cause pain and swelling in the joints of the feet. Gout, a form of arthritis that occurs when excess uric acid is deposited as monosodium in the joints and other tissues, can cause pain and swelling in the big toe.