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Clinical Image. The life-threatening DRESS (drug rash with eosinophilia and systemic symptoms) syndrome is a distinct and severe adverse drug reaction [1, 2]. This syndrome is difficult to diagnose, as many of its clinical features mimic those found with other serious systemic disorders [3]. About 44 drugs have been known to cause DRESS syndrome. The drugs that commonly cause DRESS syndrome include phenobarbital, carbamazepine [4, 5], phenytoin [5], lamotrigine, levetiracetam [6]minocycline, sulfasalazine, allopurinol, dapsone, nevirapine, celecoxib and anti-tubercular drugs [7].
Dressler syndrome is a type of pericarditis, which is the inflammation of the sac around the heart (pericardium). Itâs also called post-pericardiotomy syndrome, post-myocardial infarction syndrome, or post-cardiac injury syndrome. This is because the condition typically occurs after a heart surgery, myocardial infarction (heart attack), or injury. Dressler syndrome is thought to occur when the immune system responds excessively following one of these events. If left untreated, inflammation of the pericardium can lead to scarring, thickening, and muscle tightening of the heart, which can be life-threatening. Treatment for Dressler syndrome includes taking high doses of aspirin or other anti-inflammatory medications.