A guarantee of a person's signature is required by all Transfer Agents, under SEC Rule 17Ad-15, before a security transfer can take place. The organization that guarantees the authenticity of the signature is liable for the financial value of the transaction.
p53, also known as TP53 or tumor protein (EC :2.7.1.37) is a gene that codes for a protein that regulates the cell cycle and hence functions as a tumor suppression.It is very important for cells in multicellular organisms to suppress cancer.53 has been described as the guardian of the genome, referring to its role in conserving stability by preventing genome mutation (Strachan and Read, 1999). The name is due to its molecular mass: it is in the 53 kilodalton fraction of cell proteins.
As many as 50% of all human tumors contain p53 mutants. In normal cells, the p53 protein level is low. DNA damage and other stress signals may trigger the increase of p53 proteins, which have three major functions: growth arrest, DNA repair and apoptosis (cell death).The growth arrest stops the progression of cell cycle, preventing replication of damaged DNA.ore than 50 percent of human tumors contain a mutation or deletion of the p53 gene. In health p53 is continually produced and degraded in the cell. The degradation of p53 is, as mentioned, associated with MDM-2 binding.