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p53, also known as TP53 or tumor protein (EC :2.7.1.37) is a gene that codes for a protein that regulates the cell cycle and hence functions as a tumor suppression.It is very important for cells in multicellular organisms to suppress cancer.53 has been described as the guardian of the genome, referring to its role in conserving stability by preventing genome mutation (Strachan and Read, 1999). The name is due to its molecular mass: it is in the 53 kilodalton fraction of cell proteins.
The p53 protein plays an integral role in the cell and is normally present in all cell types. The protein is localized in the nucleus where it functions as a transcription factor. The p53 protein is at the center of a large network of proteins that 'sense' the health of a cell and cellular DNA.The p53 protein is the conductor of a well orchestrated system of cellular damage detection and control.utations. Alterations in the p53 gene have have several different effects on the activity of the gene, depending on the location of the alteration. Mutations may occur in regulatory regions. These portions of the gene control how often, and when, the gene is transcribed (this region is called the promoter).