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The worst type of liver disease is cirrhosis of the liver, which replaces healthy cells with scar tissue. Cirrhosis has different causes such as hepatitis types B, C and D; prolonged heavy drinking...
Answer Wiki. Pancreatic cancer, unfortunately, has the worst prognosis of any type of cancer. It spreads very quickly, and it is typically not detected or diagnosed until it has spread elsewhere in the body. In someone whose disease has spread to other organs like the liver, their prognosis would be very poor.