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Meatloaf is done when a meat thermometer inserted in its center reads 160 degrees Fahrenheit. Ground beef used for food items like hamburgers or meatloaf should be at this temperature after it is cooked.
A typical two pound meatloaf should be covered in foil. Preheat  oven at 375 degrees and back for 80 minutes. Next remove the foil  and cook at 375 for another 15 minutes.eatloaf should normally be cooked on 350 degrees for 40 minutes per pound. This varies between ovens, ways it is cooked, and how done a person wants the meat.