Training presents a prime opportunity to expand the knowledge base of all employees, but many employers find the development opportunities expensive. Employees also miss out on work time while attending training sessions, which may delay the completion of projects.
Cystic fibrosis is an autosomal recessive disease caused by defects in the CFTR gene, which encodes for a protein that functions as a chloride channel, and also regulates the flow of other ions across the apical surface of epithelial cells.
The clinical disease in cystic fibrosis is initiated as a result of mutations in CFTR, and is therefore called a monogenic disorder. To date, there are over 1400 mutations reported within the CFTR gene (see Cystic Fibrosis Gene Analysis Consortium, www.genet.sickkids.on.ca/cftr/).The most prevalent mutation results in the deletion of phenylalanine at position 508 (Î´F508), and occurs on 70% of all cystic fibrosis chromosomes in the USA.ven with improved treatment and better outcomes, the median age of survival is only 36.8 years. The causative cystic fibrosis gene was identified in 1989, on chromosome 7q31, and was termed the CFTR gene.