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Meatloaf is done when a meat thermometer inserted in its center reads 160 degrees Fahrenheit. Ground beef used for food items like hamburgers or meatloaf should be at this temperature after it is cooked.
Remove the meatloaf from the microwave oven after 15 minutes, and cover it with a lid or aluminum foil. After five minutes, use a meat thermometer to check the temperature. You can safely serve meatloaf if it is at least 160 degrees F. If the meatloaf is not 160 degrees F, return it to the oven for two or three minutes longer and check the temperature again.