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The aim of Bertoli was to determine the long-term effects of a ketogenic diet on body composition and bone mineral status of patients with GLUT-1 DS. Changes in body composition and bone mineral status were observed in adult patients with GLUT-1 DS who have been treated with a ketogenic diet for more than 5 years.
Long-term use of the ketogenic diet in children increases the risk of slowed or stunted growth, bone fractures and kidney stones. The diet reduces levels of insulin-like growth factor 1, which is important for childhood growth. Like many anticonvulsant drugs, the ketogenic diet has an adverse effect on bone health.