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1 People often experience an upset stomach, diarrhea (possibly bloody), abdominal pain and painful swallowing when using aspartame as a sweetener.  Skin and Allergies. Hives and intense itching, lip or mouth swelling and worsening of asthma all can occur due to aspartame.
It's worth noting that artificial sweeteners can cause gastrointestinal symptoms in some people, including diarrhea, and some IBS sufferers may be sensitive to the aspartame in Questran Light. Questran is used to treat diarrhea, as excess bile acid in the intestines can lead to loose stools. In particular, patients who have had their gallbladders removed may find that they have bile-related diarrhea, as bile is normally stored in the gallbladder.