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In addition, the neurotransmitter can bind to any one of the nearby smooth muscle cells, a flexibility not found in the NMJ. The chemicals that influence smooth muscle cells: As you'll recall, there is only one neurotransmitter released at the neuromuscular junction-acetylcholine.
Acetylcholine is a neurotransmitter that is released in the synaptic cleft and goes over the sarcolemma down the tubule and promotes the release of calcium from the sarcoreticulum which then binds to proteins on actin which exposes binding spots for myosin to attach to and powerstroke causing muscle contraction.he result of this communication is electrical excitation of the muscle cell, what we call an action potential. The action potential of the muscle cell activates that muscle and causes the muscle cell to contract or shorten. This is how our muscles are activated to do work.