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Certain heart diseases. Heart diseases, including aortic valve disease, left heart failure, mitral valve disease, and congenital heart disease, can also cause pulmonary hypertension. Thromboembolic disease. A blood clot in a large pulmonary artery can result in the development of pulmonary hypertension.
Pulmonary hypertension can be treated with medications to lower the pressure in the lung vessels and to make the heart work more efficiently. Prostacyclin dilates the blood vessels in the lungs. It is also thought to have long-term beneficial effects on the structure of the blood vessels.