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Certain heart diseases. Heart diseases, including aortic valve disease, left heart failure, mitral valve disease, and congenital heart disease, can also cause pulmonary hypertension. Thromboembolic disease. A blood clot in a large pulmonary artery can result in the development of pulmonary hypertension.
Development of Pulmonary Hypertension and Fibrosis. Interstitial lung disease, a group that includes pulmonary fibrosis, is one of the most common causes for pulmonary hypertension because of the damage it does to the vessels and lungs.