On average, the life expectancy of peritoneal mesothelioma patients is 12 months. However, multiple studies have shown that patients who have cytoreduction with HIPEC experience significantly longer survival times. Many patients now survive up to 5 years and some even live beyond 7 years.
It was written by co-creator Mark Gatiss, who also portrays Mycroft Holmes, Sherlock's brother in the series, and was directed by Paul McGuigan. The episode is a contemporary adaptation of The Hound of the Baskervilles, one of Sir Arthur Conan Doyle 's most famous works.
Since his creation in 1887, Sherlock Holmes has been played by over 75 actors including Sir Christopher Lee, Charlton Heston, Peter O'Toole, Christopher Plummer, Peter Cook, Roger Moore, John Cleese, Benedict Cumberbatch and Robert Downey Jr (above).