On average, the life expectancy of peritoneal mesothelioma patients is 12 months. However, multiple studies have shown that patients who have cytoreduction with HIPEC experience significantly longer survival times. Many patients now survive up to 5 years and some even live beyond 7 years.
It was written by co-creator Mark Gatiss, who also portrays Mycroft Holmes, Sherlock's brother in the series, and was directed by Paul McGuigan. The episode is a contemporary adaptation of The Hound of the Baskervilles, one of Sir Arthur Conan Doyle 's most famous works.
He later developed two other scripts for the director: Young Sherlock Holmes (1985) and The Goonies (1985). He made his directorial debut in 1988 with an ill-reviewed teen comedy. The next film he directed was a huge success. Columbus also took on the challenge of directing the first two Harry Potter movies. More recently, he has directed Percy Jackson & the Olympians: The Lightning Thief (2010).