Profound sedation, respiratory depression, coma, and death may result from the concomitant use of Buprenex with benzodiazepines or other CNS depressants (e.g., non-benzodiazepine sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, other opioids, alcohol).
The MOU is developed through a process of negotiation and mutual assent, finalized through acceptance of the MOU instrument, and approved by the appropriate agency representatives who signify such approval by signing the MOU.
A market-on-close order (MOC) is a non-limit market order that is executed as close to the end of the market day as possible. All MOC orders must be submitted by 3:45 p.m. ET on the NYSE and by 3:50 p.m. ET on the Nasdaq, as both of them close at 4 p.m. and neither exchange allows for the modification or cancellation of MOC orders after those times.