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A syndesmosis is defined as a fibrous joint in which two adjacent bones are linked by a strong membrane or ligaments.This definition also applies for the distal tibiofibular syndesmosis, which is a syndesmotic joint formed by two bones and four ligaments.
A syndesmotic sprain or high ankle sprain is an injury to the distal tibiofibular syndesmosis with possible disruption of the distal tibiofibular ligaments and interosseous membrane. A high ankle sprain usually occurs in combination with medial ligament injuries and/or distal tibia/fibula fractures.