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Irritating Skin Rashes: 13 Possible Causes. Not typically serious, but always irritating and embarrassing, skin rashes can be caused by a number of factorsâsuch as environment, infection, stress, heat, allergens, immune system disorders, and medication.
1 Viral exantham: Many viral infections can cause a red rash affecting large areas of the skin. 2  This is especially common in children. 3  Shingles (herpes zoster): Caused by the chickenpox virus, shingles is a painful rash on one side of the body. 4  A new adult vaccine can prevent shingles in most people.