1 The first bomb dropped on Hiroshima was made from uranium. 2  The bomb dropped on Nagasaki was made from plutonium, which was even more powerful than uranium. 3  It is thought that at least 135,000 people died from the Hiroshima explosion and another 70,000 in Nagasaki.
Pharmacokinetic parameters of paclitaxel following 3- and 24-hour infusions of TAXOL at dose levels of 135 and 175 mg/m2 were determined in a Phase 3 randomized study in ovarian cancer patients and are summarized in the following table.
The recommended dose and schedule for paclitaxel albumin-stabilized nanoparticle formulation is 125 mg/m2 administered as an intravenous infusion over 30-40 minutes on days 1, 8, and 15 of each 28-day cycle until disease progression or no longer tolerated by the patient.