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The following are some known causes of pulmonary hypertension: 1  The diet drug fen-phen.. Although the appetite suppressant fen-phen (dexfenfluramine and phentermine) has been taken off the market, former fen-phen users have a 23-fold increase risk of developing pulmonary hypertension, possibly years later.
Left heart disease is the most common cause of pulmonary hypertension. Group 3 pulmonary hypertension Group 3 is related to lung problems like chronic obstructive pulmonary disease (COPD) and interstitial lung disease, as well as sleep apnea and other sleep-related breathing disorders.