Profound sedation, respiratory depression, coma, and death may result from the concomitant use of Buprenex with benzodiazepines or other CNS depressants (e.g., non-benzodiazepine sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, other opioids, alcohol).
The MOU is developed through a process of negotiation and mutual assent, finalized through acceptance of the MOU instrument, and approved by the appropriate agency representatives who signify such approval by signing the MOU.
Mou is Memorandum of Understanding, it is just a document or a mean for two parties to reach a decision. Its a first stage of formation of Final Formal contract/Agreement. Agreement is any document which is enforceable by Law. You can have substantial rights in Agreement and not in MoU.