Cultivation of individual donors is part art and part science, and many nonprofit professionals really enjoy the relationship management process. In addition, success in a major gifts position can be a building block to a more senior development position.
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As a matter of fact, port number 25 can be blocked by some ISPs because of the ever increasing quantity of spam and malware that transit by there. So a good solution is to simply change the port to 587 or 2525 (if you're using an unencrypted connection) and 465 or 25025 for a SSL connection.