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Cervical cancer is caused by severe abnormal changes in the cells of the cervix. Most precancerous or cancerous cell changes occur in the cervix at the transformation zone, because these cells normally undergo constant change.
Nearly all cases of cervical cancer are caused by infection with oncogenic, or high-risk, types of human papillomavirus, or HPV. There are about 12 high-risk HPV types. Infections with these sexually transmitted viruses also cause most anal cancers; many vaginal, vulvar, and penile cancers; and some oropharyngeal cancers.