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In addition, the neurotransmitter can bind to any one of the nearby smooth muscle cells, a flexibility not found in the NMJ. The chemicals that influence smooth muscle cells: As you'll recall, there is only one neurotransmitter released at the neuromuscular junction-acetylcholine.
Now that we have described the structure of the neuromuscular junction, we are ready to examine what happens there. When the nerve impulse reaches the axon terminals, a chemical referred to as a neurotransmitter is released. The specific neurotransmitter that stimulates skeletal muscle cells is acetylcholine, or Ach. Acetylcholine diffuses across the synaptic cleft and attaches to receptors (membrane proteins) that are part of the sarcolemma. If enough acetylcholine is released, the sarcolemma at that point becomes temporarily more permeable to sodium ions (Na+), which rush into the muscle cell and to potassium ions (K +) which