Differentiation is an operation that allows us to find a function that outputs the rate of change of one variable with respect to another variable. Informally, we may suppose that we're tracking the position of a car on a two-lane road with no passing lanes.
Overactive bladder is typically treated with a class of drugs called anticholinergics. Examples include DetrolÂ®, DitropanÂ®, VesicareÂ®, and EnablexÂ®. Mirabegron is a new drug approved for overactive bladder that has a different mechanism of action than the anticholinergics. MECHANISM: Mirabegron (MyrbetriqÂ®) stimulates Beta-3 adrenergic receptors. Stimulation of Beta-3 adrenergic receptors in the bladder muscle causes it to relax.
As a moderate CYP2D6 inhibitor, mirabegron increased the systemic exposure to metoprolol and desipramine: ï· Mirabegron increased the Cmax of metoprolol by 90% and metoprolol AUC by 229% after multiple doses of. 160 mg mirabegron IR tablets once daily for 5 days and a single dose of 100 mg metoprolol tablet in.