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In addition, the neurotransmitter can bind to any one of the nearby smooth muscle cells, a flexibility not found in the NMJ. The chemicals that influence smooth muscle cells: As you'll recall, there is only one neurotransmitter released at the neuromuscular junction-acetylcholine.
Skeletal muscle also serves as the main site of insulin-stimulated glucose disposal, thus playing a major role in glucose homeostasis. At first glance, the action of insulin on glucose transport seems independent of its effect on skeletal Na,K-ATPase. Insulin initiates the translocation of the major glucose transporter responsible for glucose uptake into muscle and adipose tissue, GLUT4, to the plasma membrane (sarcolemma, T tubule) from an intracellular membrane storage compartment, GLUT4 storage vesicles.