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Cardiovascular disease includes conditions that affect the structures or function of your heart, such as: 1  Coronary artery disease (narrowing of the arteries) 2  Heart attack. 3  Abnormal heart rhythms, or arrhythmias.  Heart 1  failure. Heart valve disease.  Congenital heart 1  disease. Heart muscle disease (cardiomyopathy)  Pericardial disease.
Circulatory system problems arise when there is limited blood flow to the legs, hands, heart and rest of the body, including the fingers, toes and feet. The blood vessels become blocked as a fatty substance called plaque builds up and hardens and constricts the walls of the arteries and veins.