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In addition, the neurotransmitter can bind to any one of the nearby smooth muscle cells, a flexibility not found in the NMJ. The chemicals that influence smooth muscle cells: As you'll recall, there is only one neurotransmitter released at the neuromuscular junction-acetylcholine.
So letâs do a quick review of muscle contraction physiology: An action potential in a motor neuron causes acetylcholine to release in the synaptic cleft. Acetylcholine binds with receptors on the cell membrane on the muscle fiber, opening Ca2+ -Na+ channels. Usually referred to as Calcium channels. Calcium is released from the terminal cisternae into the muscle fiber.