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In addition, the neurotransmitter can bind to any one of the nearby smooth muscle cells, a flexibility not found in the NMJ. The chemicals that influence smooth muscle cells: As you'll recall, there is only one neurotransmitter released at the neuromuscular junction-acetylcholine.
a direct-acting cholinergic neurotransmitter agent widely distributed in body tissues, with a primary function of mediating the synaptic activity of the nervous system and skeletal muscles.Its half-life and duration of activity are short because it is rapidly destroyed by acetylcholinesterase.Ch binds to acetylcholine receptors on skeletal muscle fibres. Sodium enters the muscle fibre membrane, which leads to a depolarization of the membrane and muscle contraction.