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The next layer after the mucosa is called the submucosa. This layer is a thick layer of loose connective tissue. Although this layer does not have any sub-layers, it does have blood vessels, vessels belonging to the lymphatic system, and nerves, some of which control digestion.In some places, such as the small intestine, the submucosa also contains cells that secrete mucus onto the surface of the tract.After the submucosa is a layer called the muscularis externa. Except for the upper portion of the esophagus, this layer consists of smooth muscle.n some places, such as the small intestine, the submucosa also contains cells that secrete mucus onto the surface of the tract. After the submucosa is a layer called the muscularis externa. Except for the upper portion of the esophagus, this layer consists of smooth muscle.
The layers are discussed below, from the inside lining of the tract to the outside lining: 1  The mucosa is a mucous membrane that lines the inside of the digestive tract from mouth to anus. 2  The submucosa lies outside the mucosa. 3  The muscularis (muscularis externa) is a layer of muscle. In the mouth and pharynx, it consists of skeletal muscle that aids in swallowing. In the rest of the digestive tract, it consists of smooth muscle (three layers in the stomach, two layers in the small and large intestines) and associated nerve fibers.