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How alcohol and ecstasy affect ADH. Alcohol suppresses ADH production. This causes the kidneys to produce more dilute urine. It can lead to dehydration. Ecstasy increases ADH production. This causes the kidneys to reabsorb water. It can result in the body having too much water.
Central diabetes insipidus is a decrease in the production of ADH by the hypothalamus or in the release of ADH from the pituitary while nephrogenic diabetes insipidus is characterized by a decrease in the kidney's response to ADH. With this test, those with SIADH typically have decreased blood sodium and osmolality. 2  They do not produce as much urine as expected, urine osmolality is high relative to serum osmolality, and the ADH concentration is in excess of what would be appropriate and does not decrease appropriately with water loading.