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MDRO definition. For epidemiologic purposes, MDROs are defined as microorganisms, predominantly bacteria, that are resistant to one or more classes of antimicrobial agents (1).imilarly, therapeutic options are limited for ESBL-producing isolates of gram-negative bacilli, strains of A. baumannii resistant to all antimicrobial agents except imipenem(8-11, 38) and intrinsically resistant Stenotrophomonas sp.(12-14, 39).
Multidrug-resistant organisms (MDROs) are bacteria that are not able be treated with certain types of antibiotics and require treatment with other medicines that may be less effective, more toxic, and more expensive.ethicillin-resistant Staphylococcus aureus (MRSA) is a type of Staphylococcus (staph) bacteria that is resistant to certain antibiotics called beta-lactams.