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The following are some known causes of pulmonary hypertension: 1  The diet drug fen-phen.. Although the appetite suppressant fen-phen (dexfenfluramine and phentermine) has been taken off the market, former fen-phen users have a 23-fold increase risk of developing pulmonary hypertension, possibly years later.
The World Health Organization classifies human. pulmonary hypertension into five groups based on the. inciting cause (see box on page 7). Pulmonary hypertension causes pressure overload. on the right heart and can result in right ventricular. enlargement (concentric hypertrophy or thickening). This is called cor pulmonale. Acute cor pulmonale, most often caused by massive thromboembolic dis-. ease, results in right ventricular dilation, tricuspid.