1 The first bomb dropped on Hiroshima was made from uranium. 2  The bomb dropped on Nagasaki was made from plutonium, which was even more powerful than uranium. 3  It is thought that at least 135,000 people died from the Hiroshima explosion and another 70,000 in Nagasaki.
Pharmacokinetic parameters of paclitaxel following 3- and 24-hour infusions of TAXOL at dose levels of 135 and 175 mg/m2 were determined in a Phase 3 randomized study in ovarian cancer patients and are summarized in the following table.
Continuous infusion: 1 to 4 mcg/min. Anaphylaxis (adult): 0.1 to 0.5 SC / IM (1:1000) repeat q10 to 15 minutes prn or give 0.1 to 0.25 mg IV (1:10,000) over 5-10min repeat q5 to 15 minutes as needed or start continuous infusion: 1 to 4 mcg/min. Cardiac arrest: 0.5 to 1 mg bolus (1:10,000) q5min prn.