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Although it is no bigger than a pea, the pituitary gland, located at the base of the brain just beneath the hypothalamus, is considered the most important part of the endocrine system. It's often called the master gland because it makes hormones that control several other endocrine glands.
The Anterior Lobe of the pituitary plays the 'master' role secreting six major hormones that affect most of the body, including the other Endocrine glands: 1  ACTH (Adrenocorticotrophic hormone) stimulates the adrenal glands to secrete its hormones.