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A Stacy Wiegman, PharmD , Pharmacy, answered. Zofran (ondansetron) acts fairly quickly. For people who are undergoing chemotherapy, it is usually given 30 minutes before starting the chemo so that it is working when chemo starts. To prevent nausea and vomiting after surgery, it is usually given one hour before the operation.
Zofran (Ondansetron) is a medication that belongs to the drug class known as antiemetic and selective 5-HT3 receptor antagonist. Zofran is prescribed for the treatment of nausea and vomiting due to cancer chemotherapy and also used to prevent and treat nausea and vomiting after surgery. Common side effects of Zofran include diarrhea, headache, fever, lightheadedness, dizziness, drowsiness, constipation, rash, blurred vision and muscle spasm. Zofran adult dose is 32-mg given as a single dose or divided in three 0.15-mg/kg divided doses infused over 15 minutes.