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Although it is no bigger than a pea, the pituitary gland, located at the base of the brain just beneath the hypothalamus, is considered the most important part of the endocrine system. It's often called the master gland because it makes hormones that control several other endocrine glands.
It effects the endocrine system, because the hypothalamus and the pituitary gland, both s â¦ ecreting organs in the endocrine system, are located in the brain. If a stroke were to occur in those regions, the hypothalamus or the pituitary gland would not be able to secrete the hormones needed to keep homeostasis.