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Total iron binding capacity (TIBC) is a blood test to see if you have too much or too little iron in the blood. Iron moves through the blood attached to a protein called transferrin. This test helps your doctor know how well that protein can carry iron in the blood.
Iron is transported in the blood as transferrin, a major transport protein. Transferrin carries 60-70% of the bodyâs iron. The total amount of iron bound to transferrin is referred to as total iron-binding capacity (TIBC). TIBC will help your doctor differentiate between different types of anemia. TIBC is high in iron deficiency anemia and low/normal with anemia of chronic disease. TIBC is also used to help doctors diagnose iron overload, which is called hemochromatosis. Low levels of iron are associated with iron deficiency anemia.