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The following are some known causes of pulmonary hypertension: 1  The diet drug fen-phen.. Although the appetite suppressant fen-phen (dexfenfluramine and phentermine) has been taken off the market, former fen-phen users have a 23-fold increase risk of developing pulmonary hypertension, possibly years later.
Pulmonary Hypertension Treatment. In general, the treatment of pulmonary hypertension focuses on treating the underlying cause and managing the symptoms. Early recognition of the disease and appropriate management of the underlying condition is important in order to slow the rate of progression to an advanced stage. Despite advanced treatment options, there is no a cure for pulmonary hypertension. Medically Reviewed by a Doctor on 6/24/2014.