With venom capable of killing a full gown elephant, the King Cobra is the most poisonous snake known to the world. The King cobraâs venom also contains a unique protein called ohanin. Ohanin is being used today in the form of a painkiller that is 20 times more potent than morphine.
Eluxadoline is a Î¼- and Îº-opioid receptor agonist and Î´-opioid receptor antagonist that acts locally in the enteric nervous system, possibly decreasing adverse effects on the central nervous system.ollowing a 100 mg dose of eluxadoline, the Cmax was about 2 to 4 ng/ml and AUC was 12-22 ng.h/ml. Eluxadoline has linear pharmacokinetics with no accumulation upon repeated twice daily dosing. Its plasma protein binding was 81% and its half life was 3.7 to 6 hours and it was excreted mainly in feces.
A new medication, eluxadoline (MuDelta), is being investigated for the treatment of IBS-D unresolved by diet or OTC medications. This medication targets mu and delta opioid receptors in the GI tract, which are thought to influence proper GI motility, function, and secretion production. IBS-D involves abnormally increased GI motility and secretions, leading to stool urgency and abdominal pain. 2 Altering the function of these opioid receptors may improve symptoms and help regulate colon function. 8 This article will discuss the use of eluxadoline in patients with IBS-D.