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A Stacy Wiegman, PharmD , Pharmacy, answered. Zofran (ondansetron) acts fairly quickly. For people who are undergoing chemotherapy, it is usually given 30 minutes before starting the chemo so that it is working when chemo starts. To prevent nausea and vomiting after surgery, it is usually given one hour before the operation.
Zofran is a brand name for the drug ondansetron, prescribed to treat or prevent nausea and vomiting. Doctors sometimes prescribe Zofran to treat nausea and vomiting caused by cancer treatments such as chemotherapy and radiation therapy. Zofran also can treat nausea and vomiting after surgery. The drug may also help prevent the common complication of shivering in people who have had anesthesia.