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A Stacy Wiegman, PharmD , Pharmacy, answered. Zofran (ondansetron) acts fairly quickly. For people who are undergoing chemotherapy, it is usually given 30 minutes before starting the chemo so that it is working when chemo starts. To prevent nausea and vomiting after surgery, it is usually given one hour before the operation.
The ER can give you phengran or zofran for nausea to help keep you from throwing up but just do not take any antidirreah meds until you are sure. I hope you feel better. Read More. I was the same way on zofran and it also didnt really work that great for me.