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A high number of large platelets (high MPV) in a person with a low platelet count suggests the bone marrow is producing platelets and releasing them into circulation rapidly. Conversely, the MPV may be low in people with low platelet counts due to a disorder affecting production by the bone marrow.
This is because abnormally low platelets could cause internal bleeding. Usually, a blood count is conducted to determine the patientâs platelet count. In normal circumstances, a normal blood count would reveal between 150,000 and 450,000 platelets for every micro liter of blood. This would mean that a low platelet count would constitute less than 150,000 platelets. What Causes Low Platelets?