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MDRO definition. For epidemiologic purposes, MDROs are defined as microorganisms, predominantly bacteria, that are resistant to one or more classes of antimicrobial agents (1).imilarly, therapeutic options are limited for ESBL-producing isolates of gram-negative bacilli, strains of A. baumannii resistant to all antimicrobial agents except imipenem(8-11, 38) and intrinsically resistant Stenotrophomonas sp.(12-14, 39).
Most types of bacteria (germs) can be treated with antibiotics. Multi-drug resistant organisms are bacteria (germs) that have become resistant to many antibiotics. Some of these germs make enzymes (substances) which do not allow the antibiotic to work. That means that certain antibiotics will not be effective in killing or controlling the bacteria. Examples of MDROs are: