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A Stacy Wiegman, PharmD , Pharmacy, answered. Zofran (ondansetron) acts fairly quickly. For people who are undergoing chemotherapy, it is usually given 30 minutes before starting the chemo so that it is working when chemo starts. To prevent nausea and vomiting after surgery, it is usually given one hour before the operation.
I used Zofran with my last pregnancy, when I could get it to stay down, and it helped for a few days and than it felt like my body would get use to it and I would start getting sick all over again. I believe Zofran isn't making you sicker but just min. your vomiting.