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Certain heart diseases. Heart diseases, including aortic valve disease, left heart failure, mitral valve disease, and congenital heart disease, can also cause pulmonary hypertension. Thromboembolic disease. A blood clot in a large pulmonary artery can result in the development of pulmonary hypertension.
The World Health Organization classifies human. pulmonary hypertension into five groups based on the. inciting cause (see box on page 7). Pulmonary hypertension causes pressure overload. on the right heart and can result in right ventricular. enlargement (concentric hypertrophy or thickening). This is called cor pulmonale. Acute cor pulmonale, most often caused by massive thromboembolic dis-. ease, results in right ventricular dilation, tricuspid.