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Although it is no bigger than a pea, the pituitary gland, located at the base of the brain just beneath the hypothalamus, is considered the most important part of the endocrine system. It's often called the master gland because it makes hormones that control several other endocrine glands.
The hypothalamus communicates directives to these glands by one of the following two pathways: The pituitary gland is found in the inferior part of the brain and is connected by the pituitary stalk. It can be referred to as the master gland because it is the main place for everything that happens within the endocrine system.