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In addition, the neurotransmitter can bind to any one of the nearby smooth muscle cells, a flexibility not found in the NMJ. The chemicals that influence smooth muscle cells: As you'll recall, there is only one neurotransmitter released at the neuromuscular junction-acetylcholine.
In response to a stimulus, the brain or the spinal cord may initiate muscle cell contraction to enable movement. The neurotransmitter that signals muscle cell contraction is acetylcholine, and it is released in the synapse between the neuron and the muscle cell. If the acetylcholine that is released is not broken down, the muscle cells remain in a contracted state and cannot respond effectively to new signals from the brain.