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MDRO definition. For epidemiologic purposes, MDROs are defined as microorganisms, predominantly bacteria, that are resistant to one or more classes of antimicrobial agents (1).imilarly, therapeutic options are limited for ESBL-producing isolates of gram-negative bacilli, strains of A. baumannii resistant to all antimicrobial agents except imipenem(8-11, 38) and intrinsically resistant Stenotrophomonas sp.(12-14, 39).
Bacteria and Drug Resistance. Bacteria live in our bodies and in our environment, usually without causing any illness. When bacteria do make us sick, antibiotics are usually available to treat the illness. However, over time, bacteria develop resistance to some types of antibiotics. This means that the drugs are no longer effective at killing the bacteria and the infections become harder to treat. If bacteria are resistant to more than one type of antibiotic, they are called multidrug-resistant organisms, or MDROs.