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Certain heart diseases. Heart diseases, including aortic valve disease, left heart failure, mitral valve disease, and congenital heart disease, can also cause pulmonary hypertension. Thromboembolic disease. A blood clot in a large pulmonary artery can result in the development of pulmonary hypertension.
Two medications, Ofev and Esbriet, were recently fast-tracked for approval by the U.S. Food and Drug Administration (FDA) to treat idiopathic pulmonary fibrosis (IPF). Pulmonary fibrosis is a progressive lung disease typically caused by occupational and environmental factors, a response from medications, autoimmune disorders, infections, genetics and other unknown factors.