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The following are some known causes of pulmonary hypertension: 1  The diet drug fen-phen.. Although the appetite suppressant fen-phen (dexfenfluramine and phentermine) has been taken off the market, former fen-phen users have a 23-fold increase risk of developing pulmonary hypertension, possibly years later.
Pulmonary hypertension can be treated with medications to lower the pressure in the lung vessels and to make the heart work more efficiently. Prostacyclin dilates the blood vessels in the lungs. It is also thought to have long-term beneficial effects on the structure of the blood vessels.