The distinction between graduate school and professional school is somewhat like the distinction between basic science and applied science; the differences lie in the focus. In graduate school, students focus primarily on mastering a particular field of study.
Protein deglycase DJ-1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene.ARK7 belongs to the peptidase C56 family of proteins. The protein structures of human protein DJ-1, Escherichia coli chaperone Hsp31 and an Archaea protease are evolutionarily conserved.
1 The PARK7 gene is not a common locus for early onset autosomal recessive parkinsonism. 2  Mutations in the DJ-1 gene are rare in early-onset Parkinson's disease in both sporadic and familial cases. 3  We describe clinical and neuroimaging features of the 4 patients in the original PARK7-linked kindred. PARK7 protein loss of function could be due to impaired caspase-6 proteolysis and we document the fact that various PARK7 protein mutations could lead to PD pathology through distinct molecular mechanisms. 2  LRRK2 with other Parkinson's disease causing genes, Parkin, DJ-1 and PINK-1.