With venom capable of killing a full gown elephant, the King Cobra is the most poisonous snake known to the world. The King cobraâs venom also contains a unique protein called ohanin. Ohanin is being used today in the form of a painkiller that is 20 times more potent than morphine.
Updated: Eluxadoline is a prescription medication used to irritable bowel syndrome with diarrhea (IBS-D) in adults. Eluxadoline belongs to a group of drugs called mu-opioid receptor antaognists. The exact mechanism of eluxadoline in IBS-D is not known, but eluxadoline interacts with opioid receptors in the gut.This medication comes in tablet form and is taken 2 times a day with food.t is not known if eluxadoline crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication.
Eluxadoline is a mu-opioid receptor agonist; eluxadoline is also a delta opioid receptor antagonist and a kappa opioid receptor agonist. The binding affinities (Ki) of eluxadoline for the human mu and delta opioid receptors are 1.8 nM and 430 nM, respectively.The binding affinity (Ki) of eluxadoline for the human kappa opioid receptor has not been determined; however, the Ki for guinea pig cerebellum kappa opioid receptor is 55 nM.In animals, eluxadoline interacts with opioid receptors in the gut.oadministration of a single dose of 100 mg VIBERZI with a single dose of 500 mg probenecid resulted in a 35% and 31% increase in eluxadoline AUC and Cmax, respectively, compared to administration of VIBERZI alone. This change in eluxadoline exposures is not expected to be clinically meaningful.