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[edit on Wikidata] Pituitary ACTH hypersecretion (or Cushing disease) is a form of hyperpituitarism characterized by an abnormally high level of ACTH produced by the anterior pituitary. It is one of the causes of Cushing's syndrome. (However, Cushing's syndrome can be caused by many other causes, including exogenous administration.) ^ Drouin J, Bilodeau S, Vallette S (September 2007). Of old and new diseases: genetics of pituitary ACTH excess (Cushing) and deficiency.
Cushing syndrome is caused by an overgrowth of cells in the adrenal gland that produce cortisol. The tumor that results leads to overproduction of cortisol and increased drinking, eating, urination, and enlarged, distended abdomen, skull-like look to head. These tumors do not typically invade other tissues, remaining confined to an enlargement of their original area.