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[edit on Wikidata] Pituitary ACTH hypersecretion (or Cushing disease) is a form of hyperpituitarism characterized by an abnormally high level of ACTH produced by the anterior pituitary. It is one of the causes of Cushing's syndrome. (However, Cushing's syndrome can be caused by many other causes, including exogenous administration.) ^ Drouin J, Bilodeau S, Vallette S (September 2007). Of old and new diseases: genetics of pituitary ACTH excess (Cushing) and deficiency.
Hyperadrenocorticism can occur spontaneously due to a pituitary tumor, or, in 85 percent of cases, to enlargement of the pituitary gland. Cushingâs disease refers specifically to an increase in cortisone due to a benign tumor of the pituitary gland. In 15 percent of cases, spontaneous hyperadrenocorticism occured as a result of cortisol-secreting adrenocortical cancer, half of all such adrenocortical cancers will metastasize (spread).