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Medical Definition of degenerative. : of, relating to, involving, or tending to cause degeneration degenerative conditions of the nervous systemâMorris Fishbein degenerative changes a degenerative muscle disorder.
Degenerative or mechanical arthritis. Degenerative or mechanical arthritis is a group of conditions where the main problem is damage to the cartilage which covers the ends of the bones.Normally the smooth, slippery cartilage helps the joint to move smoothly.egenerative or mechanical arthritis. Degenerative or mechanical arthritis is a group of conditions where the main problem is damage to the cartilage which covers the ends of the bones.