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Medical Definition of degenerative. : of, relating to, involving, or tending to cause degeneration degenerative conditions of the nervous systemâMorris Fishbein degenerative changes a degenerative muscle disorder.
â¢ DEGENERATION (noun) The noun DEGENERATION has 3 senses: 1. the process of declining from a higher to a lower level of effective power or vitality or essential quality. 2. the state of being degenerate in mental or moral qualities. 3. passing from a more complex to a simpler biological form.