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Presynaptic neurons are the neurons that conduct the AP to release a neurotransmitter and they affect the postsynaptic neurons. What ALWAYS causes a neuron to release any neurotransmitter (whether it is excitatory or inhibitory) is an action potential.ontrast that with exitatory NTs: All excitatory neurotransmitters cause an opening of ligand-gated sodium ion channels. The inhibitory NT could also cause an opening up of ligand-gated Chloride Ion channels.
The excitatory neurotransmitters, the most common of which is glutamate, then migrate via diffusion to the dendritic spine of the postsynaptic neuron and bind a specific transmembrane receptor protein that triggers the depolarization of that cell.hen neurotransmitters reach the postsynaptic neuron of an excitatory synapse, these molecules can bind to two possible types of receptors that are clustered in a protein-rich portion of the postsynaptic cytoskeleton called the Postsynaptic density (PSD).