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[edit on Wikidata] Pituitary ACTH hypersecretion (or Cushing disease) is a form of hyperpituitarism characterized by an abnormally high level of ACTH produced by the anterior pituitary. It is one of the causes of Cushing's syndrome. (However, Cushing's syndrome can be caused by many other causes, including exogenous administration.) ^ Drouin J, Bilodeau S, Vallette S (September 2007). Of old and new diseases: genetics of pituitary ACTH excess (Cushing) and deficiency.
In dogs, cushings disease (hyperadrenocorticism) is a condition commonly caused by excessive long-term exposure to the hormone corticosteroids. The tumor cells cause the pituitary gland to over produce ACTH. 2  This results in the over-production of corticosteroids by the adrenal glands. 3  Tumors of Adrenal Glands: The remaining cases of spontaneous Cushing's disease are caused by a tumor in either one, or in rare cases, both of the adrenal glands.