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The mean terminal plasma elimination half-lives of racemic tramadol and racemic M1 are 6.3Â±1.4 and 7.4Â±1.4 hours, respectively. The plasma elimination half-life of racemic tramadol increased from approximately six hours to seven hours upon multiple dosing.
Tramadol withdrawals last longer than those of opiates and follow the withdrawal syndrome length of antidepressants. Tramadol has a relatively short half-life that helps to explain the severity of the withdrawals frequently experienced by patients. Tramadol should be tapered slowly to minimize withdrawal symptoms. Yet even with a gradual taper, many complain that the symptoms are debilitating and interfere with every aspect of life.