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DRUG DESCRIPTION. WELLBUTRIN XLÂ® (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin reuptake inhibitor, or other known antidepressant agents. Its structure closely resembles that of diethylpropion; it is related to phenylethylamines.
A: Wellbutrin (bupropion) is approved for the treatment of depression. Wellbutrin is in a class of medications known as aminoketones. Wellbutrin is not related to other antidepressant medications such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), or other antidepressant classes.