The neuromuscular junction is the site of the signal exchange. The steps of this process in vertebrates occur as follows:(`) The action potential reaches the axon terminal. (2) Voltage-dependent calcium gates open, allowing calcium to enter the axon terminal.he neuromuscular junction is the site of the signal exchange. The steps of this process in vertebrates occur as follows:(`) The action potential reaches the axon terminal. (2) Voltage-dependent calcium gates open, allowing calcium to enter the axon terminal.
Sudden onset pain on the outer side of the foot can be from a fracture of the 5th Metatarsal and injuries to this bone are a common sports injury. Causes of pain on the outside of the foot are listed here: 1  Midtarsal Joint Sprain A mid tarsal joint sprain is an injury to the ligaments holding the mid tarsal joint together causing pain in the outside middle of the foot. 2  Peroneus Brevis Tendon Injury The Peroneus Brevis tendon inserts into the 5th matatarsal bone on the outside of the foot.
Some common causes of pain in the feet and toes include claudication, gout and arthritis, according to the American Orthopaedic Foot & Ankle Society and Mayo Clinic. Claudication is a sign of peripheral artery disease and indicates reduced or blocked blood circulation in the foot.