While ALS is the most common motor neuron disease, we also treat all other forms, including: 1  PLS (Primary Lateral Sclerosis), affecting the upper motor neurons in the brain and spinal cord. 2  PMA (Primary Muscular Atrophy), affecting the lower motor neurons from the spine to the muscle.
Deletion Mutation and DNA. A deletion mutation occurs when part of a DNA molecule is not copied during DNA replication. This uncopied part can be as small as a single nucleotide or as much as an entire chromosome.The loss of this DNA during replication can lead to a genetic disease.eletion Mutation and DNA. A deletion mutation occurs when part of a DNA molecule is not copied during DNA replication. This uncopied part can be as small as a single nucleotide or as much as an entire chromosome.
The result can either be a change of protein product, or silent mutation (no change in protein product), or an incomplete and nonfunctional protein. Deletion mutation occurs when a portion of the DNA is taken away, or deleted. Insertion mutation happens when an extra pairs of amino acids are inserted in the sequence. When insertion and deletion mutation occurs, it also causes a frameshift mutation where a gene can no longer be correctly transcribed. slide 5 of 6.