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The mean terminal plasma elimination half-lives of racemic tramadol and racemic M1 are 6.3Â±1.4 and 7.4Â±1.4 hours, respectively. The plasma elimination half-life of racemic tramadol increased from approximately six hours to seven hours upon multiple dosing.
Tramadol withdrawals can last longer than typical Opioid withdrawals. The length and severity of withdrawal symptoms depends in the duration of Duralgesic usage by patients, and usually last from 7 days to several weeks.