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The mean terminal plasma elimination half-lives of racemic tramadol and racemic M1 are 6.3Â±1.4 and 7.4Â±1.4 hours, respectively. The plasma elimination half-life of racemic tramadol increased from approximately six hours to seven hours upon multiple dosing.
There are anti-depressant properties in tramadol and the drug itself is a synthetic opiate, made from the scrap of thrown-out codeine. It has a longer half life, making withdrawal longer and much more painful. It also may cause seizures.ramadol is superior for managing some withdrawal symptomsMany medications have been used to treat opiate and opioid withdrawal symptoms in the past few decades. Aside from new methods of withdrawal such as rapid opiate detox, these medicines have been tested and are generally thought to be safe.