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Lipase is a digestive enzyme produced by the following organs: pancreas (pancreatic lipase), liver (hepatic lipase), and stomach (stomach/gastric lipase). Enzymes are responsible for the metabolism of carbohydrates, proteins, and fats.
Although there is a gastric lipase secreted in the stomach that causes a small amount of fat digestion, and infants produce a salivary lipase, almost all of the digestion of fat takes place in the small intestine. Like protein digestion, fat digestion is achieved through the activity of both pancreatic and intestinal brush border lipases.