While ALS is the most common motor neuron disease, we also treat all other forms, including: 1  PLS (Primary Lateral Sclerosis), affecting the upper motor neurons in the brain and spinal cord. 2  PMA (Primary Muscular Atrophy), affecting the lower motor neurons from the spine to the muscle.
Deletion Mutation and DNA. A deletion mutation occurs when part of a DNA molecule is not copied during DNA replication. This uncopied part can be as small as a single nucleotide or as much as an entire chromosome.The loss of this DNA during replication can lead to a genetic disease.eletion Mutation and DNA. A deletion mutation occurs when part of a DNA molecule is not copied during DNA replication. This uncopied part can be as small as a single nucleotide or as much as an entire chromosome.
frameshift mutation / frame-shift mutation; frameshift. A frameshift mutation is a genetic mutation caused by a deletion or insertion in a DNA sequence that shifts the way the sequence is read.A DNA sequence is a chain of many smaller molecules called nucleotides.rameshift mutations arise when the normal sequence of codons is disrupted by the insertion or deletion of one or more nucleotides, provided that the number of nucleotides added or removed is not a multiple of three.