Drugs versus Biologics. 1  A biologic is manufactured in a living system such as a microorganism, or plant or animal cells. 2  Most biologics are very large, complex molecules or mixtures of molecules.enerics Drugs versus Follow-On Biologics. 1  To be approved as a generic, a drug must have the same active ingredient, strength, dosage form, and route of administration as the reference drug, and it must also be bioequivalent..
Viruses (e.g., adenovirus, astrovirus, rotavirus, Norwalk virus) are the most common cause of diarrhea in the United States. The most common ones in children are rotavirus and in adults are norovirus. Escherichia coli, Clostridium difficile, and Campylobacter, Salmonella, and Shigella spp. are common bacterial causes.
When first described over 30 years ago, MC was believed to be rare. However, studies have shown that it is a common cause of watery diarrhoea, particularly in older female patients. MC is a disease that predominantly affects older patients, with incidence rates anywhere from 5 to 10 times higher in those over 65. Some population-based studies have looked at the incidence of MC in European and North American populations.