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Medical Definition of degenerative. : of, relating to, involving, or tending to cause degeneration degenerative conditions of the nervous systemâMorris Fishbein degenerative changes a degenerative muscle disorder.
degeneration. deterioration; change from a higher to a lower form, especially change of tissue to a lower or less functionally active form. When there is chemical change of the tissue itself it is true degeneration; when the change consists in the deposit of abnormal matter in the tissues, it is infiltration.apetoretinal degeneration degeneration of the pigmented layer of the retina. transneuronal degeneration atrophy of certain neurons after interruption of afferent axons or death of other neurons to which they send their efferent output.