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DRUG DESCRIPTION. WELLBUTRIN XLÂ® (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin reuptake inhibitor, or other known antidepressant agents. Its structure closely resembles that of diethylpropion; it is related to phenylethylamines.
Rather, bupropion and its primary metabolite, hydroxybupropion, decreased the reuptake of dopamine and norepinephrine into rat and mouse synaptosomes (sacs formed by presynaptic neuronal membranes that mimic presynaptic neuronal terminal activity).