In which case, it depends on the type of inhibitor. A competitive inhibitor has a structure similar to the substrate, hence would bind to the active site as well, competing with the substrate for the enzyme active sites, decreasing enzymatic activity. A non-competitive inhibitor binds to the allosteric site of the enzyme, causing a structural change in the enzyme active site shape.
There's a difference between the effects of cold-brewed coffee vs. hot-brewed coffee: because different chemical reactions are achieved at higher temperatures, cold-brewed coffee will have a smoother caffeine effect and overall less acidity, which some people experience as part of the kick..
Hot and cold Hot and cold Diabetic peripheral neuropathy can also result in exaggerated sensations. Holding a cup of warm coffee may feel painfully hot. It may also hurt when a person with cold hands touches you. And your hands or feet may feel hot or cold for no apparent reason. Advertisement.