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Medical Definition of degenerative. : of, relating to, involving, or tending to cause degeneration degenerative conditions of the nervous systemâMorris Fishbein degenerative changes a degenerative muscle disorder.
verb (used with object), degenerated, degenerating. 5. to cause degeneration in; bring about a decline, deterioration, or reversion in. adjective. 6. having fallen below a normal or desirable level, especially in physical or moral qualities; deteriorated; degraded: