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Vial: Once the vial is punctured, it is OPEN. Once you stick a needle in the vial, it is OPEN. OPEN vials can be stored in the fridge or at CONTROLLED room temperature. Regardless of where it is stored, OPEN insulin will only last 28 days before it must be thrown in the trash.
The package insert that comes with your insulin specifies how long it remains good once it is opened, or you can ask your local pharmacist. If the insulin is unopened, it must be kept refrigerated and is good until the expiration date on the vial or pen. The problem with using opened insulin beyond the guidelines listed on the package is that the insulin can lose its potency and not work as well to lower blood glucose levels.