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Medical Definition of degenerative. : of, relating to, involving, or tending to cause degeneration degenerative conditions of the nervous systemâMorris Fishbein degenerative changes a degenerative muscle disorder.
Medical Definition of degenerate. 1a: having declined (as in nature, character, structure, or function) from an ancestral or former state; especially : having deteriorated progressively (as in the process of evolution) especially through loss of structure and functionb: having sunk to a lower and usually corrupt and vicious state.