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The mean terminal plasma elimination half-lives of racemic tramadol and racemic M1 are 6.3Â±1.4 and 7.4Â±1.4 hours, respectively. The plasma elimination half-life of racemic tramadol increased from approximately six hours to seven hours upon multiple dosing.
Tramadol duration of action. Tramadol hits its peak blood plasma level an hour and a half after the drug is taken. Tramadol has a half life of 6 hours. The immediate-release tramadol tablet will need to be taken every 4-6 hours for continuous pain relief.The extended-release tramadol tablet, used mainly to manage chronic pain, will last for 24 hours, and is only taken once a day.ramadol duration of action. Tramadol hits its peak blood plasma level an hour and a half after the drug is taken. Tramadol has a half life of 6 hours. The immediate-release tramadol tablet will need to be taken every 4-6 hours for continuous pain relief.