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Medical Definition of degenerative. : of, relating to, involving, or tending to cause degeneration degenerative conditions of the nervous systemâMorris Fishbein degenerative changes a degenerative muscle disorder.
Degeneration in a joint means the joint surfaces are starting to break down over time. The term degenerative arthritis is used by doctors to describe a condition where a joint wears out, usually over a period of many years. Some medical professionals call the condition osteoarthritis.