While ALS is the most common motor neuron disease, we also treat all other forms, including: 1  PLS (Primary Lateral Sclerosis), affecting the upper motor neurons in the brain and spinal cord. 2  PMA (Primary Muscular Atrophy), affecting the lower motor neurons from the spine to the muscle.
Deletion Mutation and DNA. A deletion mutation occurs when part of a DNA molecule is not copied during DNA replication. This uncopied part can be as small as a single nucleotide or as much as an entire chromosome.The loss of this DNA during replication can lead to a genetic disease.eletion Mutation and DNA. A deletion mutation occurs when part of a DNA molecule is not copied during DNA replication. This uncopied part can be as small as a single nucleotide or as much as an entire chromosome.
Such a change leads to a premature termination of translation, which can badly affect the formation of proteins. Insertion/Deletion Mutations When a nucleotide is wrongly inserted or deleted from a codon, the affects can be drastic. Called a frameshift mutation, an insertion or deletion can affect every codon in a particular genetic sequence by throwing the entire three by three codon structure out of whack. For example, given the code: