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1 A typical level of HDL-C is between 40-50 mg/dL (1.0-1.3 mmol/L) for men and between 50-59 mg/dl (1.3-1.5 mmol/L) for women and is associated with average risk of heart disease. 2  Based on many epidemiologic studies, HDL-C of 60 mg/dL (1.55 mmol/L) or higher is associated with a less than average risk of heart disease.
Before menopause, women generally tend to have higher HDL-cholesterol levels than men -- averaging 55 mg/dL in women and 45 mg/dL in men. But after menopause, these protective levels of HDL cholesterol can drop. For women over age 70, HDL cholesterol--not total cholesterol -- more clearly identifies those at higher risk of coronary heart disease; however, HDL cholesterol is generally not a direct target of therapy, as LDL cholesterol is.