In which case, it depends on the type of inhibitor. A competitive inhibitor has a structure similar to the substrate, hence would bind to the active site as well, competing with the substrate for the enzyme active sites, decreasing enzymatic activity. A non-competitive inhibitor binds to the allosteric site of the enzyme, causing a structural change in the enzyme active site shape.
There's a difference between the effects of cold-brewed coffee vs. hot-brewed coffee: because different chemical reactions are achieved at higher temperatures, cold-brewed coffee will have a smoother caffeine effect and overall less acidity, which some people experience as part of the kick..
How to Make Low Acid Coffee. While coffee is a much-revered daily habit for many people, it does carry its own drawbacks. Coffee can stain your teeth, make you jittery and unfocused, and coffee's high acidity can irritate sensitive stomachs. Fortunately, there is a simple way to brew coffee with much of its acidity removed. This process is called cold brewing, and will allow you to make low acid coffee in both hot and iced forms.