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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
Although rare in most implementing L-arginine, some minimal side effects have come up in people who have tried this powerful nitric oxide booster. Some rare but potential L-Arginine side effects include stomach pains, bloating, and sometimes diarrhea in certain individuals. L-Arginine has shown no adverse side effects in children or pregnant women when taken in moderation and with approval from a doctor.