Actinic keratoses that develop on the lips are referred to as actinic cheilitis. The clinical appearance of an actinic keratosis is that of a small (several millimeters), red scaly papule or plaque, with induration and thickening of the epidermis.
1 Location: Ideally, the probe should be in close proximity to the forward or reverse primer, but should not overlap with a primer-binding site on the same strand. 2  Probes can be designed to bind to either strand of the target. 3  Melting temperature (Tm): Preferably, probes should have a Tm 6â8Â°C higher than the primers.
Reverse-bias is when the anode is negative and the cathode is positive. A lot of current flows when the diode is forward-biased, provided that the voltage is higher than 0.6V or so for a silicon diode or 0.3V or so for a germanium device. A very small amount of current flows if a diode is reverse-biased.