what causes liver and spleen swelling 1 One of the most likely causes of an enlarged spleen is an infection, since swelling in the spleen signifies an increase in white blood cells that are trying to attack something threatening. 2  Leishmaniasis, a type of parasitic disease found in parts of the tropics, subtropics and southern Europe, can lead to an enlarged spleen. more information...
Do not take Tylenol and ibuprofen together if you are taking any other medications for pain without first checking with a doctor. Some medicines, like cold medicine, contain ibuprofen or acetaminophen, and taking more puts you at risk for an overdose.
Answer: Naproxen and Acetaminophen (the ingredient in Tylenol and Tylenol Extra Strength) are compatible drugs. The two drugs can be taken at the same time. Talk to your doctor about your plan to take acetaminophen to be sure it is the best therapy for you. The link below has additional information on naproxen.