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They can weigh anywhere from 110 pounds to the 343 pounds of Zorba, the world's largest dog, although most Mastiff males weigh around 160-230 pounds and females around 120-170 pounds.
This breed is the tallest of all dogs, even the Great Dane. According to breed standards, the minimum height should be 32 inches for males and 30 inches for females. That's just the minimum.Males often stand as tall as 34-35 inches and weigh upwards of 140 pounds.Photo:Stanimir G.Stoev/Shutterstock). Mastiff breeds are certainly among the largest dogs in terms of sheer mass. The Neapolitan mastiff originated in southern Italy. Used as a guard dog, the average male mastiff stands between 26-31 inches tall and weighs a hefty 130-155 pounds.