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In its early stages, some of the symptoms of ALS can be similar to those of MS. These include: Stiff, weak muscles; Twitching or spasms; Fatigue; Trouble walking; If youâre having these symptoms, donât try to guess what's going on. See a doctor and get a diagnosis. As ALS attacks the nerves that deal with movement, your symptoms will get worse.
In about 25% of cases, ALS begins with brainstem symptoms (dysarthria, difficulty swallowing) followed by extremity weakness. This variant is called progressive bulbar palsy and has a worse prognosis. Some ALS patients have only lower motor neuron involvement (progressive muscular atrophy).egeneration may also infrequently involve sensory tracts. Spinal Spinal Muscular atrophy (SMA) is a genetic disorder that causes degeneration and loss of spinal and brain stem motor neurons (lower motor neurons) resulting in progressive muscle weakness.