Many congenital brain defects cause minor neurological impairment. People with these types of congenital brain defects can grow to function independently. Other defects are so severe that they are fatal before or shortly after birth. Some cause significant disabilities.
I am looking into this for a friend as well. The pancreas deals with digestive juices and insulin. Have a look at your medications to see if they may have gastrointestinal effects. I can tell you that Tramadol does affect the production of enzymes in the intestine.
Glimepiride lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) ...Pioglitazone may cause heart failure and bladder cancer..