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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
Higher doses obviously come with more risk for side effects, plus some research shows that more is not always better when it comes to L-arginineâs functions within blood vessel walls. Interactions and Side Effects: Although L-arginine is generally safe considering itâs a natural amino acid, there are some potential side effects to keep in mind. If you have a history of heart disease, low blood pressure, diabetes, kidney problems or an active virus (like herpes or shingles), itâs not recommended to supplement with L-arginine until you speak with a doctor first.