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Most people who have piriformis syndrome get better with treatment and lifestyle changes. Failure to treat this condition can lead to permanent nerve damage, so be sure to follow your doctorâs instructions.
From Wikipedia, the free encyclopedia. Piriformis syndrome is a neuromuscular disorder that occurs when the sciatic nerve is compressed or otherwise irritated by the piriformis muscle causing pain, tingling and numbness in the buttocks and along the path of the sciatic nerve descending the lower thigh and into the leg.owever, compression may be present, but not causal, in the setting of sciatica due to piriformis syndrome. The syndrome may be due to anatomical variations in the muscle-nerve relationship, or from overuse or strain.