A regulatory framework Although common in other process manufacturing industries (e.g., food and chemicals), continuous processing is at a nascent stage in the pharmaceutical industry, where batch manufacturing is the prevailing mode.
When the motor neurons in the brainstem are affected (bulbar ALS), the muscles used in speech and swallowing are impaired. ALS only affects muscles that are moved voluntarily (such as those in the mouth or arm) and does not impact those muscles involved in involuntary movements, such as digestion.
Early symptoms of ALS disease include muscle weakness or stiffness beginning in the hands and feet, according to the ALS Association. As the disease progresses, the muscles weaken and paralysis spreads to the trunk muscles. As the disease progresses, speech, swallowing, chewing and breathing are affected.