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Most people who have piriformis syndrome get better with treatment and lifestyle changes. Failure to treat this condition can lead to permanent nerve damage, so be sure to follow your doctorâs instructions.
However, surgical observation and cadaver studies reveal that variations in the relationship between the two occur in as much as 22% of the population (see figure 1)(1). Piriformis syndrome is an irritation of the sciatic nerve caused by an inflammation of the piriformis muscle.Athletes may complain of a deep aching pain in the buttock or a radiating sharp nerve pain that extends along the middle of the rear thigh. Occasionally, numbness and tingling can continue to the calf and toes.hile athletes are usually symptomatic in only one leg, the pain-free leg should be treated as well. In the New York study, investigators determined the most common causes of piriformis syndrome are overuse (43% of 876 patients) and trauma (18% of 892 patients).