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Researchers have determined that Werner Syndrome is caused by abnormal changes (mutations) of a gene (known as the WRN gene) located on the short arm of chromosome 8 (8p12-11.2).* More than 80 different mutations of the WRN gene have been identified in individuals with the disorder.ymptoms of the following disorders can be similar to those of Werner Syndrome. Comparisons may be useful for a differential diagnosis: Hutchinson-Gilford Progeria Syndrome is a very rare disorder of childhood characterized by premature aging, short stature, and characteristic facial features.
Causes of Werner Syndrome. Werner Syndrome is caused by mutations of the WRN gene, and there are a number of different mutations that can cause the condition. WRN has been identified as important in order to manufacture Werner protein in the body, which is required to repair and maintain DNA.y Mark Jaimison. Werner Syndrome is uncommon, but it is one of the more regular types of premature ageing disorders seen in humans and was identified in 1904 by a German scientist, Dr. Otto Werner.