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Long-term treatment with ibuprofen at a dose of 1200 mg/day does not increase the risk of renal impairment in elderly people (Griffin et al, 2000). Ibuprofen is associated with a low risk of renal toxicity in overdose (Jenkinson et al, 1988; Volans and Fitzpatrick, 1999).
Ibuprofen is not safe for continuous, daily, long-term use due to its affect on the liver, kidneys and blood pressure.Watch pain management expert Devi Nampiaparampil, MD, explain how too much ibuprofen can have a negative impact over time.t can also increase the risk of bleeding in the stomach. Your doctor will need to regularly test your urine and blood if you are taking ibuprofen long-term. Over-the-counter ibuprofen should not be used for more than 10 days to treat body aches, unless directed to do so by your doctor.