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VERY DIFFERENT: Parkinson's is disease of misfolded protein usually occurring in older males, associated with tremor, stiffness, loss of balance, etc. Multiple sclerosis is an autoimmune mediated disorder of people in their 20's and 30's, occas in childhood, and typically a pattern of ...Read more.
Degeneration of the motor neurons in the brainstem (bulbar ALS) first affects an individual's ability to speak loudly and clearly (dysarthria). Eventually, the condition completely prevents speaking and vocalizing. Some of the earliest speech-related symptoms of ALS may include: