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How to Take PRISTIQ. Most people start with a once-daily 50-mg dose of PRISTIQ (taken with or without food). Your doctor may keep you on your starting dose throughout your treatment.Talk to your doctor about any health conditions you may have, as your dose might be affected.PRISTIQ should be taken at the same time each day and always swallowed whole, since the tablets are time released.our doctor may keep you on your starting dose throughout your treatment. Talk to your doctor about any health conditions you may have, as your dose might be affected. PRISTIQ should be taken at the same time each day and always swallowed whole, since the tablets are time released.
Days 4 to 6: 100 to 125 mg b.i.d. Days 7 to 9: 100 to 125 mg t.i.d. Day 10 to maintenance: 250 mg t.i.d. For most adults and children 8 years of age and over, the usual maintenance dosage is three to four 250 mg Primidone tablets in divided doses (250 mg t.i.d. or q.i.d.). If required, an increase to five or six 250 mg tablets daily may be made but daily doses should not exceed 500 mg q.i.d.