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VERY DIFFERENT: Parkinson's is disease of misfolded protein usually occurring in older males, associated with tremor, stiffness, loss of balance, etc. Multiple sclerosis is an autoimmune mediated disorder of people in their 20's and 30's, occas in childhood, and typically a pattern of ...Read more.
One huge difference in the presentation of these two neurological diseases is that the symptoms of ALS all involve nerves that control voluntary muscle movement, whereas the nerves affected in MS affect both voluntary and involuntary muscle movement. That said, there is more to the story.