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In its early stages, some of the symptoms of ALS can be similar to those of MS. These include: Stiff, weak muscles; Twitching or spasms; Fatigue; Trouble walking; If youâre having these symptoms, donât try to guess what's going on. See a doctor and get a diagnosis. As ALS attacks the nerves that deal with movement, your symptoms will get worse.
Signs and Symptoms. ALS affects the upper motor neurons, which are in the brain, and the lower motor neurons, which are in the spinal cord and brainstem. Upper motor neuron degeneration generally causesspasticity (tightness in a muscle), while lower motor neuron degeneration causes muscle weakness, muscle atrophy(shrinkage of muscles) and twitching. These can occur in combination in ALS, as upper and lower motor neurons are being lost at the same time.