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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
L-Arginine Improves the Circulatory System Health of Patients Suffering From Diabetes Type 1. L-Arginine has long been recommended as part of the nutritional treatment of diabetes alongside medication. L-Arginine increases the rate of release of insulin from the pancreas, improving diabeticsâ tolerance of sugar. The dangers that stem from diabetes are side effects of having a high blood sugar level. They include impaired circulation, especially in the thin layer of cells which line blood vessels to filter the cells in the blood and control blood pressure, and more difficulties with processing oxygen.