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Long-term treatment with ibuprofen at a dose of 1200 mg/day does not increase the risk of renal impairment in elderly people (Griffin et al, 2000). Ibuprofen is associated with a low risk of renal toxicity in overdose (Jenkinson et al, 1988; Volans and Fitzpatrick, 1999).
Consumers can use expired ibuprofen, but the potency of ibuprofen cannot be guaranteed by the manufacturer after the expiration date. Many medications are safe for use up to one year after they expire, but it varies with environmental conditions, according to Drugs.com.