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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
Although there are few documented side effects of L-arginine, users of arginine should be aware of some of the possible side effects. Some arginine side effects include: breathing problems; swelling in the legs; headaches; low blood pressure; diarrhea; chest pain; nausea, bloating; taking arginine may also increase the amount of Herpes simples (cold sore) outbreaks; L-Arginine Supplements