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Causes of Human Skin Hyperpigmentation. The color of human skin is due primarily to the production of melanin by specialized cells in the skin called melanocytes. Melanin produced by these cells both absorbs and scatters UV radiation and thus protects skin from the damaging and mutagenic effects of the solar radiation.
Diffuse hyperpigmentation may have a systemic cause, such as Addison's disease, hyperthyroidism, or hemochromatosis. It also may occur because of a medication side effect. In Addison's disease, the adrenal glands fail to produce adequate amounts of mineralo-corticoids and glucocorticoids.ystemic symptoms may indicate the presence of hyperthyroidism, Addison's disease, or diabetes-related disorders. A review of medication use, supplement use, and exposure to plants and ultraviolet radiation can help determine whether hyperpigmentation is caused by a medication side effect or a phototoxic reaction.