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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
Although L-arginine is considered safe in moderate doses, too much L-arginine can have severe side effects, including death. It is important to understand how the supplement may interact with the body and with additional medications before taking it.