Lock and Key Model. Each type of enzyme has a unique 3-D shape, including a surface groove called an active site, which fits its target substrate much like a key fits in a lock. Other substances that donât fit can't enter the active site and no reaction occurs.
Some of the many causes of hypoxia are the following: 1  Chemical or gas poisoning (for example cyanide, carbon monoxide) 2  Low or absent concentration of oxygen (for example, high altitudes reached without supplemental oxygen as seen in mountain climbing, and aviation, drowning or fires)  Lung problems, for example:
The causes of both environmental and tissue hypoxia often result in the intermediate state of hypoxemia; thus the causes of any type of hypoxia are also potential causes of hypoxemia. Some of the many causes of hypoxia are the following: 1  Chemical or gas poisoning (for example cyanide, carbon monoxide)  Low or absent concentration of oxygen (for example, high altitudes reached without supplemental oxygen as seen in mountain climbing, and aviation, drowning or fires)