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VERY DIFFERENT: Parkinson's is disease of misfolded protein usually occurring in older males, associated with tremor, stiffness, loss of balance, etc. Multiple sclerosis is an autoimmune mediated disorder of people in their 20's and 30's, occas in childhood, and typically a pattern of ...Read more.
Patients may have trouble moving, swallowing and speaking. An ALS diagnosis requires signs of both upper and lower motor neuron damage. Signs of the former include muscle tightness or stiffness and abnormal reflexes; signs of the latter include muscle weakness, cramps, twitches and atrophy.[ Related: Nervous System: Facts, Functions & Diseases ].atients may have trouble moving, swallowing and speaking. An ALS diagnosis requires signs of both upper and lower motor neuron damage. Signs of the former include muscle tightness or stiffness and abnormal reflexes; signs of the latter include muscle weakness, cramps, twitches and atrophy.