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Long-term treatment with ibuprofen at a dose of 1200 mg/day does not increase the risk of renal impairment in elderly people (Griffin et al, 2000). Ibuprofen is associated with a low risk of renal toxicity in overdose (Jenkinson et al, 1988; Volans and Fitzpatrick, 1999).
Ibudone (hydrocodone bitartrate and ibuprofen tablets)is indicated for the short-term (generally less than 10 days) management of acute pain. Ibudone tablets are not indicated for the treatment of such conditions as osteoarthritis or rheumatoid arthritis.