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Inhibitors are a serious medical problem that can occur when a person with hemophilia has an immune response to treatment with clotting factor concentrates. The immune system defends the body from harmful germs and viruses.
Overview [edit]. Enzyme inhibitors are molecules or compounds that bind to enzymes and result in a decrease in their activity. An inhibitor can bind to an enzyme and stop a substrate from entering the enzyme's active site and/or prevent the enzyme from catalyzing a chemical reaction. The inhibitor has an affinity for the active site of an enzyme where the substrate also binds to. 2  This type of inhibition can be overcome by increasing the concentrations of substrate, out-competing the inhibitor. 3  Competitive inhibitors are often similar in structure to the real substrate.