Phosphorylation of signal transduction molecules is a major activating event that leads to dramatic changes in tumor growth. Some TKs, such as epidermal growth factor receptor (EGFR)-TK, can autophosphorylate when activated, as well as phosphorylating other signaling molecules [2].
Risk indexes Definition: Categories of risk used to calculate fundamental beta, including (1) market variability, (2) earnings variability, (3) low valuation, (4) immaturity and smallness, (5) growth orientation, and (6) financial risk.
In 2005, NCREIF released an open-end Fund level index, the NCREIF Fund Index-Open End Diversified Core Equity (NFI-ODCE). Different from the NPI, the NFI-ODCE is comprised of only open-end funds, and excludes all the closed-end and separate account real estate portfolios. The NFI-ODCE index reports on both a historical and current basis the results of 23 open-end, commingled funds pursuing a core investment strategy. Currently, the benchmark includes funds with total market value of $142 billion, net real estate asset value. The index includes property investments at ownership share, cash balances and leverage, allowing it to reflect the fund's actual asset ownership positions and financing strategy.