anything done or to be done; anything requiring action or effort; business; concern: an affair of great importance. 2. affairs, matters of commercial or public interest or concern; the transactions of public or private business or finance:
Hyperlactatemia is defined as a persistent, mild to moderate (2-4 mmol/L) increase in blood lactate concentration without metabolic acidosis, whereas lactic acidosis is characterized by persistently increased blood lactate levels (usually >5 mmol/L) in association with metabolic acidosis.
The predictive power of the lactate level was independent of blood pressure and co-variates. In patients with normal blood pressure, increased blood lactate levels (>4.0 mmol/l) were associated with a ten times higher mortality rate than normal lactate levels (mortality 26.5%).