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Long-term treatment with ibuprofen at a dose of 1200 mg/day does not increase the risk of renal impairment in elderly people (Griffin et al, 2000). Ibuprofen is associated with a low risk of renal toxicity in overdose (Jenkinson et al, 1988; Volans and Fitzpatrick, 1999).
Long-term use of ibuprofen can increase the risk for heart attack, stroke and ulcers. It can also increase the risk of bleeding in the stomach. Your doctor will need to regularly test your urine and blood if you are taking ibuprofen long-term. Over-the-counter ibuprofen should not be used for more than 10 days to treat body aches, unless directed to do so by your doctor. Do not use ibuprofen to treat your child's fever for longer than three days.