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Long-term treatment with ibuprofen at a dose of 1200 mg/day does not increase the risk of renal impairment in elderly people (Griffin et al, 2000). Ibuprofen is associated with a low risk of renal toxicity in overdose (Jenkinson et al, 1988; Volans and Fitzpatrick, 1999).
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is also effective for mild to moderate pain in children and adults and is considered to be safe if taken as directed. It may be more effective than acetaminophen for inflammatory pain, such as that associated with arthritis.