A regulatory framework Although common in other process manufacturing industries (e.g., food and chemicals), continuous processing is at a nascent stage in the pharmaceutical industry, where batch manufacturing is the prevailing mode.
When the motor neurons in the brainstem are affected (bulbar ALS), the muscles used in speech and swallowing are impaired. ALS only affects muscles that are moved voluntarily (such as those in the mouth or arm) and does not impact those muscles involved in involuntary movements, such as digestion.
ALS-Amyotrophic Lateral Sclerosis. Amyotrophic Lateral Sclerosis (ALS), commonly known as Lou Gehrig's disease, is a progressive neuromuscular disease. ALS is characterized by a progressive degeneration of motor nerve cells in the brain (upper motor neurons) and spinal cord (lower motor neurons).ach individual, however, may experience symptoms differently. Symptoms may include: 1  twitching and cramping of muscles, especially those in the hands and feet. 2  loss of motor control in the hands and arms. 3  impaired use of the arms and legs. 4  weakness and fatigue. 5  tripping and falling. 6  dropping things.