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Inhibitors are a serious medical problem that can occur when a person with hemophilia has an immune response to treatment with clotting factor concentrates. The immune system defends the body from harmful germs and viruses.
Inhibitors are substances which alter or interfere with the action of the enzyme to slow it down or stop it. Competitive inhibitors mimic the structure of the substrate. They can fit into the active site, prohibiting the substrate from interacting with the enzyme. This can either slow down or prevent a reaction from occurring depending upon the concentrations of the inhibitor and substrate.