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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
Any drug or supplement can cause side effects. L-arginine is no exception. L-arginine affects the way your body handles waste, so it can have adverse effects on the organs involved in waste disposal. Some liver and kidney problems can be exacerbated by L-arginine. Using L-arginine can also lead to problems of potassium balance and dehydration, as well as stomach cramps, nausea and other digestive discomfort [source: MedlinePlus]. Keep Reading Below There can also be some circulatory side effects associated with L-arginine.