In contemporary standard English, these are the second-person pronouns: 1  you (singular and plural personal pronoun). 2  yours (singular and plural possessive pronoun). 3  yourself and yourselves (singular and plural reflexive / intensive pronouns).
A Cochrane review came to the result that in women starting hormone replacement therapy less than 10 years after menopause have a lower mortality and lower rate of coronary heart disease compared to placebo or no treatment, without any strong evidence of an effect on the risk of stroke.
Long-term hormone replacement therapy used to be routinely prescribed for postmenopausal women to relieve hot flashes and other menopause symptoms. Hormone replacement therapy was also thought to reduce the risk of heart disease. Before menopause, women have a lower risk of heart disease than men do. But as women age, and their estrogen levels decline after menopause, their risk of heart disease increases. In the 1980s and 1990s, experts advised older women to take estrogen and other hormones to keep their hearts healthy.