what causes liver and spleen swelling 1 One of the most likely causes of an enlarged spleen is an infection, since swelling in the spleen signifies an increase in white blood cells that are trying to attack something threatening. 2  Leishmaniasis, a type of parasitic disease found in parts of the tropics, subtropics and southern Europe, can lead to an enlarged spleen. more information...
Do not take Tylenol and ibuprofen together if you are taking any other medications for pain without first checking with a doctor. Some medicines, like cold medicine, contain ibuprofen or acetaminophen, and taking more puts you at risk for an overdose.
Is It Safe to Take Tylenol (Acetaminophen) with Advil or Motrin (Ibuprofen)? Yes, you can take them together, and they even work better in combination than separately. Several large studies have shown that ibuprofen (Advil, Motrin) and acetaminophen (Tylenol) together work well to relieve pain, with few side effects. In fact, for many things like dental pain, they work better than many of the opioid-containing pain meds (like Vicodin or Norco).