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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
Other Side Effects. L-arginine supplementation can lead to several potentially serious side effects in addition to an allergic reaction. In some users, arginine supplementation may cause stomach discomfort, including nausea, stomach cramps, or increased bowel movements. Arginine may also worsen the symptoms of asthma and lower blood pressure.