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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
Side effects. Most people taking arginine have few side effects. It can cause nausea, cramps, diarrhea, allergic reactions, and asthma symptoms. It could also cause low blood pressure and changes to glucose and blood chemical levels.