22q11.2 deletion syndrome is caused by the deletion of a small section of chromosome 22. It results in a cleft palate, heart defects, autoimmune disorders, and more. The symptoms vary wildly and can be accompanied by learning disabilities and mental illness. Cystic fibrosis is caused by a point deletion.
The melody of Happy Birthday to You comes from the song  Good Morning to All , which has been attributed to American siblings Patty Hill and Mildred J. Hill in 1893, although the claim that the sisters composed the tune is disputed.
Top 65 happy songs. MR BLUE SKY (1977) Jeff Lynne wrote this foot-tapping ditty while locked in a chalet in the Swiss alps, trying to come up with a follow-up album to Electric Light Orchestra's hit A New World Record. After a fortnight of gloomy weather and writers' block suddenly the sun came out and ELO's Mr Blue Sky was born.