anything done or to be done; anything requiring action or effort; business; concern: an affair of great importance. 2. affairs, matters of commercial or public interest or concern; the transactions of public or private business or finance:
Hyperlactatemia is defined as a persistent, mild to moderate (2-4 mmol/L) increase in blood lactate concentration without metabolic acidosis, whereas lactic acidosis is characterized by persistently increased blood lactate levels (usually >5 mmol/L) in association with metabolic acidosis.
When there is kidney damage or kidney disease, and the kidneys are not able to filter waste efficiently, there will likely be a rise in creatinine levels in the blood. For adults with kidney disease, dialysis is recommended when creatinine levels reach 10.0 mg/dL. creatinine clearance test is usually ordered if the serum creatinine level is higher than normal or when a person is starting dialysis. Normal creatinine clearance for men is between 97 to 137 milliliters per minute, and women have a normal clearance of 88 to 128 milliliters per minute.