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In yet another embodiment of the pharmaceutical composition of the invention, aspirin is enteric coated as described above and the statin (pravastatin, simvastatin, lovastatin, atorvastatin, fluvastatin and cerivastatin) can optionally be enteric coated.
ABSTRACT. Simvastatin is a semisynthetic derivative of the fungal polyketide lovastatin and is an important drug for lowering cholesterol levels in adults. We have developed a one-step, whole-cell biocatalytic process for the synthesis of simvastatin from monacolin J. By using an Escherichia coli S.Simvastatin (Fig. 1) is a cholesterol-lowering compound that significantly reduces the risk of heart diseases associated with hypercholesterolemia (17).Simvastatin is marketed by Merck as Zocor and is the second-best-selling drug in the United States, with annual sales exceeding $5 billion.BSTRACT. Simvastatin is a semisynthetic derivative of the fungal polyketide lovastatin and is an important drug for lowering cholesterol levels in adults. We have developed a one-step, whole-cell biocatalytic process for the synthesis of simvastatin from monacolin J. By using an Escherichia coli S.