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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
There are also minor side effects associated with l-arginine that can be experienced as a result of overdose. Some of these side effects are nausea, diarrhea, and weakness in the body. This is why it is important that you pay close attention to the type of diet you are following.