what causes liver and spleen swelling 1 One of the most likely causes of an enlarged spleen is an infection, since swelling in the spleen signifies an increase in white blood cells that are trying to attack something threatening. 2  Leishmaniasis, a type of parasitic disease found in parts of the tropics, subtropics and southern Europe, can lead to an enlarged spleen. more information...
Do not take Tylenol and ibuprofen together if you are taking any other medications for pain without first checking with a doctor. Some medicines, like cold medicine, contain ibuprofen or acetaminophen, and taking more puts you at risk for an overdose.
Also.... The reason you take Ibuprofen for both (or tylenol) is because of thow they act in the body. Ibuprofen and Tylenol can both reduce a fever and can also act on pain. for example, Ibuprofen acts to inhibit prostaglandins, this will in turn reduce fever and help to reduce pain.