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VERY DIFFERENT: Parkinson's is disease of misfolded protein usually occurring in older males, associated with tremor, stiffness, loss of balance, etc. Multiple sclerosis is an autoimmune mediated disorder of people in their 20's and 30's, occas in childhood, and typically a pattern of ...Read more.
The onset of ALS/MND may be so subtle that symptoms are overlooked or misread. The earliest symptoms may include: 1  Muscle weakness. 2  Muscle twitches (fasciculations). 3  Cramps and/or tight and stiff muscles (spasticity). 4  Muscle loss and/or atrophy. 5  Slurred and nasal speech. 6  Difficulty chewing and swallowing. 7  Excessive choking. 8  Excessive shortness of breath. 9  Unintended weight loss.