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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
L-Arginine Can Cause Some Serious Side Effects. While a very low percentage of side effects are serious they can occur. If you begin to have symptoms that seem to worsen, or concern you in any way, go to the emergency room immediately.