anything done or to be done; anything requiring action or effort; business; concern: an affair of great importance. 2. affairs, matters of commercial or public interest or concern; the transactions of public or private business or finance:
Hyperlactatemia is defined as a persistent, mild to moderate (2-4 mmol/L) increase in blood lactate concentration without metabolic acidosis, whereas lactic acidosis is characterized by persistently increased blood lactate levels (usually >5 mmol/L) in association with metabolic acidosis.
Treatment of types A and B lactic acidosis is similar to treatment of other metabolic acidoses. Treatment of the cause is paramount. Bicarbonate is potentially dangerous in high anion gap acidosis but may be considered when pH < 7.00, with a target pH of â¤ 7.10. In d-lactic acidosis, treatment is IV fluids, restriction of carbohydrates, and sometimes oral antibiotics (eg, metronidazole).