anything done or to be done; anything requiring action or effort; business; concern: an affair of great importance. 2. affairs, matters of commercial or public interest or concern; the transactions of public or private business or finance:
Hyperlactatemia is defined as a persistent, mild to moderate (2-4 mmol/L) increase in blood lactate concentration without metabolic acidosis, whereas lactic acidosis is characterized by persistently increased blood lactate levels (usually >5 mmol/L) in association with metabolic acidosis.
Lactate concentration in blood reflects the level of anaerobic cellular metabolism taking place in the body and is most commonly used as an indicator of tissue hypoperfusion. The lactate value increases before changes are seen in heart rate, blood pressure, or urine output, making it a more sensitive indicator of hypoperfusion.