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Researchers have determined that Werner Syndrome is caused by abnormal changes (mutations) of a gene (known as the WRN gene) located on the short arm of chromosome 8 (8p12-11.2).* More than 80 different mutations of the WRN gene have been identified in individuals with the disorder.ymptoms of the following disorders can be similar to those of Werner Syndrome. Comparisons may be useful for a differential diagnosis: Hutchinson-Gilford Progeria Syndrome is a very rare disorder of childhood characterized by premature aging, short stature, and characteristic facial features.
Werner syndrome has an autosomal recessive pattern of inheritance. Werner syndrome (WS), also known as adult progeria , is a rare, autosomal recessive progeroid syndrome (PS), which is characterized by the appearance of premature aging.Werner syndrome is named after the German scientist Otto Werner.erner syndrome has an autosomal recessive pattern of inheritance. Werner syndrome (WS), also known as adult progeria , is a rare, autosomal recessive progeroid syndrome (PS), which is characterized by the appearance of premature aging. Werner syndrome is named after the German scientist Otto Werner.