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They can weigh anywhere from 110 pounds to the 343 pounds of Zorba, the world's largest dog, although most Mastiff males weigh around 160-230 pounds and females around 120-170 pounds.
An English Mastiff is recorded as the biggest dog in history, but opponents say the dog was massively overweight. In general, he weighs in at about 160 pounds. Small dogs, especially teacup-size designer breeds, seem to be the fashion these days.