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Causes of Human Skin Hyperpigmentation. The color of human skin is due primarily to the production of melanin by specialized cells in the skin called melanocytes. Melanin produced by these cells both absorbs and scatters UV radiation and thus protects skin from the damaging and mutagenic effects of the solar radiation.
Hyperpigmentation is a condition that causes the skin to darken. It can occur in small patches or cover large areas of the body. It can also affect the entire body. Hyperpigmentation is usually not harmful.But it can be a symptom of another medical condition. They are related to excess sun exposure over time. 2  They generally appear as spots of hyperpigmentation on areas frequently exposed to the sun, such as the hands and face. 3  Post-inflammatory hyperpigmentation is a result of prior injury to the skin (American College of Osteopathic Dermatology).