Actinic keratoses that develop on the lips are referred to as actinic cheilitis. The clinical appearance of an actinic keratosis is that of a small (several millimeters), red scaly papule or plaque, with induration and thickening of the epidermis.
1 Location: Ideally, the probe should be in close proximity to the forward or reverse primer, but should not overlap with a primer-binding site on the same strand. 2  Probes can be designed to bind to either strand of the target. 3  Melting temperature (Tm): Preferably, probes should have a Tm 6â8Â°C higher than the primers.
If the polarity of the applied voltage is reversed, then the diode will be reverse biased and will appear non-conducting. Almost no current will flow and there will be a large voltage across the device. Fig - 2 : Reverse Biased Diode. The non-symmetric behavior is due to the detailed properties of the pn-junction.