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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
Potential Side Effects. The only known side effect of beta-alanine supplementation is paresthesia, a prickly sensation mainly limited to the face and hands. Doses greater than about 800 mg have generally been reported to result in moderate to severe paresthesia lasting 60-90 minutes. 11,12. Beta-Alanine's Bottom Line