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They can weigh anywhere from 110 pounds to the 343 pounds of Zorba, the world's largest dog, although most Mastiff males weigh around 160-230 pounds and females around 120-170 pounds.
He's considered the largest breed in the world and can weigh 220 pounds or more. A Mastiff named Zorba, listed in the 1989 Guinness Book of Records, weighed in at 323 pounds. Although the Mastiff's size makes him appear fierce, his temperament is one of good-natured docility.