22q11.2 deletion syndrome is caused by the deletion of a small section of chromosome 22. It results in a cleft palate, heart defects, autoimmune disorders, and more. The symptoms vary wildly and can be accompanied by learning disabilities and mental illness. Cystic fibrosis is caused by a point deletion.
The melody of Happy Birthday to You comes from the song  Good Morning to All , which has been attributed to American siblings Patty Hill and Mildred J. Hill in 1893, although the claim that the sisters composed the tune is disputed.
June 17, 2010 | By Jon Burlingame, Special to the Los Angeles Times. Max Steiner, the pioneering film composer who wrote the music for King Kong and Gone With the Wind, was once complimented as the man who invented modern movie music. Nonsense, he replied. The idea originated with Richard Wagner. Listen to the incidental scoring behind the recitatives in his operas.