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In yet another embodiment of the pharmaceutical composition of the invention, aspirin is enteric coated as described above and the statin (pravastatin, simvastatin, lovastatin, atorvastatin, fluvastatin and cerivastatin) can optionally be enteric coated.
Simvastatin has not been studied in patients younger than 10 years of age, in premenarchal girls, nor at doses greater than 40 mg per day. Safety and efficacy have only been evaluated in patients aged 10 to 17 years with heterozygous familial hypercholesterolemia, with female patients at least one year post menarche.