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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
Some research has shown that oral L-arginine can lower blood pressure in healthy people and people with a type of high blood pressure that affects the arteries in the lungs and the right side of the heart (pulmonary hypertension). Infusions of L-arginine also appear to reduce blood pressure in people with hypertension. Erectile dysfunction.