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They can weigh anywhere from 110 pounds to the 343 pounds of Zorba, the world's largest dog, although most Mastiff males weigh around 160-230 pounds and females around 120-170 pounds.
(Photo:Stanimir G.Stoev/Shutterstock). Mastiff breeds are certainly among the largest dogs in terms of sheer mass. The Neapolitan mastiff originated in southern Italy. Used as a guard dog, the average male mastiff stands between 26-31 inches tall and weighs a hefty 130-155 pounds.