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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
Dosage, length of use and when to take L-arginine will differ based on use and health status. Duration: According to WebMD, clinical trials indicate arginine can be safely used with only a few minor side effects for up to three months. Some of the minor side effects include bloating, diarrhea and abdominal pain.