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Researchers have determined that Werner Syndrome is caused by abnormal changes (mutations) of a gene (known as the WRN gene) located on the short arm of chromosome 8 (8p12-11.2).* More than 80 different mutations of the WRN gene have been identified in individuals with the disorder.ymptoms of the following disorders can be similar to those of Werner Syndrome. Comparisons may be useful for a differential diagnosis: Hutchinson-Gilford Progeria Syndrome is a very rare disorder of childhood characterized by premature aging, short stature, and characteristic facial features.
There are many causes of optic neuritis unassociated with multiple sclerosis, including: 1  Infections: Bacterial infections, including Lyme disease, tuberculosis, cat scratch fever, toxoplasmosis and syphilis, or viral infections such as HIV, hepatitis B, and herpes zoster can cause optic neuritis. Radiation therapy to the head is an uncommon cause of optic neuritis. 2  Leber's hereditary optic neuropathy, an inherited form of vision loss that affects mostly males in their 20s or 30s, may cause optic neuritis.