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Long-term treatment with ibuprofen at a dose of 1200 mg/day does not increase the risk of renal impairment in elderly people (Griffin et al, 2000). Ibuprofen is associated with a low risk of renal toxicity in overdose (Jenkinson et al, 1988; Volans and Fitzpatrick, 1999).
Kidney damage and dysfunction is usually caused by long-term use of ibuprofen. Long-term use of non-steroidal anti-inflammatory, ibuprofen has resulted in renal papillary necrosis and other kidney impairment, as per the âPDR Guide to Drug Interactions, Side Effects, and Indicationsâ.