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N-Acetylcysteine (NAC) is a prodrug for L-cysteine, which is used for the intention of allowing more glutathione to be produced when it would normally be depleted. Through glutathione buffering, NAC provides antioxidative effects and other benefits. This page features 107 unique references to scientific papers.
Historical use of N-acetylcysteine. N-acetylcysteine (NAC) has been used as an antioxidant precursor to glutathione (Î³-glutamylcysteinylglycine; GSH) in the treatment of paracetamol overdose for more than 30 years. As more is understood about the actions of NAC, the clinical applications have also broadened.