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Long-term treatment with ibuprofen at a dose of 1200 mg/day does not increase the risk of renal impairment in elderly people (Griffin et al, 2000). Ibuprofen is associated with a low risk of renal toxicity in overdose (Jenkinson et al, 1988; Volans and Fitzpatrick, 1999).
Ibuprofen (eye-byoo-PRO-fen) is an over-the-counter medicine taken to relieve aches and pain and reduce fever. It's a safe drug when used correctly, but taking too much can make a child very sick. Overdosing can lead to stomach or intestinal problems. So it's important to know how to properly give the medicine.