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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
Proponents claim that L-arginine can also benefit: 1  colds. 2  dementia. 3  hair. 4  high blood pressure. 5  intermittent claudication. 6  interstitial cystitis. 7  male infertility. 8  migraines. 9  preeclampsia. 10  sexual dysfunction in women.