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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
Though dialysis hinders L-arginine production in the body, supplements can increase blood sugar, another example of the intricacies of the body. But perhaps the worst side effect of L-arginine is anaphylaxis, an extremely severe allergic reaction known to cause shock and maybe even death. An anaphylactic reaction is most unpleasant. You may have sudden chills, diarrhea, shortness of breath, hives, tremors, sweating and even fainting - sometimes all at the same time.