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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
Reports of myalgia and clinically significant increases in liver function tests (LFTs) were noted to be as high as 4% and 7.4%, respectively.1-7 Although the exact incidence is unknown, the most severe side effects of pitavastatin include hypersensitivity reactions and rhabdomyolysis; similar to other statins.