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VERY DIFFERENT: Parkinson's is disease of misfolded protein usually occurring in older males, associated with tremor, stiffness, loss of balance, etc. Multiple sclerosis is an autoimmune mediated disorder of people in their 20's and 30's, occas in childhood, and typically a pattern of ...Read more.
When the motor neurons in the brainstem are affected (bulbar ALS), the muscles used in speech and swallowing are impaired. ALS only affects muscles that are moved voluntarily (such as those in the mouth or arm) and does not impact those muscles involved in involuntary movements, such as digestion.