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Causes of Human Skin Hyperpigmentation. The color of human skin is due primarily to the production of melanin by specialized cells in the skin called melanocytes. Melanin produced by these cells both absorbs and scatters UV radiation and thus protects skin from the damaging and mutagenic effects of the solar radiation.
Hyperpigmentation in skin is caused by an increase in melanin, the substance in the body that is responsible for color (pigment). Certain conditions, such as pregnancy or Addison's disease (decreased function of the adrenal gland), may cause a greater production of melanin and hyperpigmentation.ypopigmentation in skin is the result of a reduction in melanin production. Examples of hypopigmentation include: 1  Vitiligo: Vitiligo causes smooth, white patches on the skin. 2  In some people, these patches can appear all over the body.