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Researchers have determined that Werner Syndrome is caused by abnormal changes (mutations) of a gene (known as the WRN gene) located on the short arm of chromosome 8 (8p12-11.2).* More than 80 different mutations of the WRN gene have been identified in individuals with the disorder.ymptoms of the following disorders can be similar to those of Werner Syndrome. Comparisons may be useful for a differential diagnosis: Hutchinson-Gilford Progeria Syndrome is a very rare disorder of childhood characterized by premature aging, short stature, and characteristic facial features.
Ehlers-Danlos syndrome-caused by mutations in the COL1A1 gene. Several mutations in the COL1A1 gene are responsible for the arthrochalasia type of Ehlers-Danlos syndrome. These genetic changes lead to the production of a pro-Î±1(I) chain that is missing a critical segment.ype I collagen is the most abundant form of collagen in the human body. The COL1A1 gene produces a component of type I collagen called the pro-Î±1(I) chain. Collagens begin as procollagen molecules, which must be processed by enzymes outside the cell to remove extra protein segments from their ends.