what causes liver and spleen swelling 1 One of the most likely causes of an enlarged spleen is an infection, since swelling in the spleen signifies an increase in white blood cells that are trying to attack something threatening. 2  Leishmaniasis, a type of parasitic disease found in parts of the tropics, subtropics and southern Europe, can lead to an enlarged spleen. more information...
Do not take Tylenol and ibuprofen together if you are taking any other medications for pain without first checking with a doctor. Some medicines, like cold medicine, contain ibuprofen or acetaminophen, and taking more puts you at risk for an overdose.
If you have hepatitis or bad liver would not take tylenol; or bad kidney or allergies to anti-inflammatory medicine/aspirin, would not take aleve (naproxen). Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Germanovich on mixing tylenol and ibuprofen: Would consider alternating them, and not taking the maximum allowable dose for each, rather take less 25% less than that.