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VERY DIFFERENT: Parkinson's is disease of misfolded protein usually occurring in older males, associated with tremor, stiffness, loss of balance, etc. Multiple sclerosis is an autoimmune mediated disorder of people in their 20's and 30's, occas in childhood, and typically a pattern of ...Read more.
One of the earliest symptoms of ALS is muscle weakness. Approximately 60 percent of patients with ALS develop this symptom, which can lead to hand weakness, tripping and arm or leg fatigue, warns the ALS Association. Sensations of weakness most commonly arise in the legs, arms or hands. Initially, muscle weakness is typically mild.