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Long-term treatment with ibuprofen at a dose of 1200 mg/day does not increase the risk of renal impairment in elderly people (Griffin et al, 2000). Ibuprofen is associated with a low risk of renal toxicity in overdose (Jenkinson et al, 1988; Volans and Fitzpatrick, 1999).
If you're taking it long-term for chronic pain, consider having liver function tests done once or twice a year. Ibuprofen. Brand names: Motrin, Advil. Best for: This nonsteroidal anti-inflammatory drug (NSAID) is effective for pain relief and fever reduction.