A regulatory framework Although common in other process manufacturing industries (e.g., food and chemicals), continuous processing is at a nascent stage in the pharmaceutical industry, where batch manufacturing is the prevailing mode.
When the motor neurons in the brainstem are affected (bulbar ALS), the muscles used in speech and swallowing are impaired. ALS only affects muscles that are moved voluntarily (such as those in the mouth or arm) and does not impact those muscles involved in involuntary movements, such as digestion.
Some of the most common causes of ALS may include: 1  Heavy metal toxicity. 2  Head and neck trauma. 3  Genetic predisposition.  Low levels of magnesium and 1  calcium. Anti-oxidant deficiency including SOD and glutathione.  Depletion of essential fatty 1  acids. Low levels of vitamin E and vitamin  B12. Exposure to toxins including pesticides.