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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
One of the most severe potential side effects of L-arginine is anaphylaxis [source: Mayo Clinic]. That's a very severe allergic reaction that can result in shock and potentially even death. In an anaphylactic reaction, you may experience sudden chills, sweating, tremors, hives, vomiting, and diarrhea, shortness of breath and light-headedness or fainting -- all at once.