A regulatory framework Although common in other process manufacturing industries (e.g., food and chemicals), continuous processing is at a nascent stage in the pharmaceutical industry, where batch manufacturing is the prevailing mode.
When the motor neurons in the brainstem are affected (bulbar ALS), the muscles used in speech and swallowing are impaired. ALS only affects muscles that are moved voluntarily (such as those in the mouth or arm) and does not impact those muscles involved in involuntary movements, such as digestion.
4 stages of ALS disease. When the upper motor neurons face a serious problem such as degeneration, this causes spastic, also known as muscle contraction or tightening. Whereas, the effects on the lower motor neurons cause loss in the ability to move, muscle shrinkage, twitching, and weakness in the muscles as well.