Actinic keratoses that develop on the lips are referred to as actinic cheilitis. The clinical appearance of an actinic keratosis is that of a small (several millimeters), red scaly papule or plaque, with induration and thickening of the epidermis.
1 Location: Ideally, the probe should be in close proximity to the forward or reverse primer, but should not overlap with a primer-binding site on the same strand. 2  Probes can be designed to bind to either strand of the target. 3  Melting temperature (Tm): Preferably, probes should have a Tm 6â8Â°C higher than the primers.
Depending on the voltage applied across it, a diode will operate in one of three regions: 1  Forward bias: When the voltage across the diode is positive the diode is âonâ and current can run through. 2  Reverse bias: This is the âoffâ mode of the diode, where the voltage is less than VF but greater than -VBR. In this mode current flow is (mostly) blocked, and the diode is off. A very small amount of current (on the order of nA) â called reverse saturation current â is able to flow in reverse through the diode.