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VERY DIFFERENT: Parkinson's is disease of misfolded protein usually occurring in older males, associated with tremor, stiffness, loss of balance, etc. Multiple sclerosis is an autoimmune mediated disorder of people in their 20's and 30's, occas in childhood, and typically a pattern of ...Read more.
Early symptoms of ALS disease include muscle weakness or stiffness beginning in the hands and feet, according to the ALS Association. As the disease progresses, the muscles weaken and paralysis spreads to the trunk muscles. As the disease progresses, speech, swallowing, chewing and breathing are affected.