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VERY DIFFERENT: Parkinson's is disease of misfolded protein usually occurring in older males, associated with tremor, stiffness, loss of balance, etc. Multiple sclerosis is an autoimmune mediated disorder of people in their 20's and 30's, occas in childhood, and typically a pattern of ...Read more.
Later symptoms of Parkinsonâs disease include: 1  Akinesia (difficulty beginning or maintaining muscle movements) 2  Anxiety and emotional changes. 3  Blank stare.  Bradykinesia (a type of slowness of 1  movement) Constipation and urination difficulties.  Difficulty speaking, chewing and 1  swallowing. Fatigue and weakness.