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Long-term treatment with ibuprofen at a dose of 1200 mg/day does not increase the risk of renal impairment in elderly people (Griffin et al, 2000). Ibuprofen is associated with a low risk of renal toxicity in overdose (Jenkinson et al, 1988; Volans and Fitzpatrick, 1999).
Ibuprofen is not safe for continuous, daily, long-term use due to its affect on the liver, kidneys and blood pressure. Watch pain management expert Devi Nampiaparampil, MD, explain how too much ibuprofen can have a negative impact over time.