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Long-term treatment with ibuprofen at a dose of 1200 mg/day does not increase the risk of renal impairment in elderly people (Griffin et al, 2000). Ibuprofen is associated with a low risk of renal toxicity in overdose (Jenkinson et al, 1988; Volans and Fitzpatrick, 1999).
Ibuprofen, Naproxen: No Heart Risk. Nov. 28, 2005 - Long-term use of two popular over-the-counter pain relievers does not appear to increase a person's risk of having a heart attack, a study from the U.K. shows. Researchers reported no increase in risk among people who took either ibuprofen or naproxen for a year or longer in moderate doses. Ibuprofen and naproxen are among the best-selling nonsteroidal anti-inflammatory drugs (NSAIDs). Ibuprofen-based pain relievers include Advil, Motrin, and Nuprin. Naproxen-based products include Aleve and Naprosyn. A slight, but significant, increase in risk for nonfatal heart attacks was seen among people who took the prescription NSAID diclofenac, known by the brand name Voltaren, for more than a year.