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â¢ Mitochondrial DNA is found inside the mitochondria while nuclear DNA is found inside the nucleus of a cell. â¢ One cell contains approximately 99.75% of nuclear DNA and 0.25% of mitochondrial DNA.â¢ The mutation rate of mitochondrial DNA is nearly twenty times faster than that of nuclear DNA.he uniqueness of mitochondrial DNA is that it is maternally inherited as a linked set of genes, passed on to progeny in the cytoplasm of the egg cell; thus no recombination between maternal and paternal genomes occurs.
Both are small. And while most of a eukaryotic cellâs DNA is in its nucleus, mitochondria have some DNA of their own as well as ribosomes to translate its genes into proteins. Nuclear DNA is in the form of double helical strands, but mitochondrial DNA is not. Though the mitochondrial genome is much smaller than a bacterial genome, both mitochondria and prokaryotes have circular DNA.