22q11.2 deletion syndrome is caused by the deletion of a small section of chromosome 22. It results in a cleft palate, heart defects, autoimmune disorders, and more. The symptoms vary wildly and can be accompanied by learning disabilities and mental illness. Cystic fibrosis is caused by a point deletion.
The melody of Happy Birthday to You comes from the song  Good Morning to All , which has been attributed to American siblings Patty Hill and Mildred J. Hill in 1893, although the claim that the sisters composed the tune is disputed.
Today, we recognize this as a âbox of chocolatesâ and we enjoy using them as a way to show our loved ones our affection on Valentineâs Day (âThe Story of Cadburyâ). Cadbury box of chocolates. 1893- Juicy Fruit Chewing Gum and Wrigleyâs Spearmint Chewing Gum are invented by William Wrigley Jr. William Wrigley Jr.