anything done or to be done; anything requiring action or effort; business; concern: an affair of great importance. 2. affairs, matters of commercial or public interest or concern; the transactions of public or private business or finance:
Hyperlactatemia is defined as a persistent, mild to moderate (2-4 mmol/L) increase in blood lactate concentration without metabolic acidosis, whereas lactic acidosis is characterized by persistently increased blood lactate levels (usually >5 mmol/L) in association with metabolic acidosis.
Key Points. Lactate concentration in blood is a measure of anaerobic metabolism, which occurs when cells are not getting enough oxygen to support normal aerobic energy production. An elevated lactate level is most commonly caused by a decrease in blood flow to the cells, systemically or locally.