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Pituitary dependent hypercortisolism, more commonly known as Cushing's disease, is caused by a pituitary tumor (non-cancerous) that triggers excessive levels of the stress hormone cortisol.
A small percentage of dogs with Cushingâs disease have a tumor of one of the adrenal glands which may or may not be cancerous. This form of Cushingâs is called adrenal dependent Cushingâs and results from a direct increase in cortisol production by the adrenal gland tumor. Every year, roughly 100,000 dogs are diagnosed with Cushingâs disease in the United States. Most dogs are six years of age or older when diagnosed, but it can occur in younger dogs. The disease is rare in cats.