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Pituitary dependent hypercortisolism, more commonly known as Cushing's disease, is caused by a pituitary tumor (non-cancerous) that triggers excessive levels of the stress hormone cortisol.
Cushingâs syndrome is caused by high cortisol levels. Cushingâs disease is a specific form of Cushingâs syndrome. People with Cushingâs disease have high levels of cortisol because they have a non-cancerous (benign) tumor in the pituitary gland.The tumor releases adrenocorticotropin hormone (ACTH), which causes the adrenal glands to produce excessive cortisol.Cushingâs syndrome that is not Cushingâs disease can be also caused by high cortisol levels that result from tumors in other parts of the body.he tumor releases adrenocorticotropin hormone (ACTH), which causes the adrenal glands to produce excessive cortisol. Cushingâs syndrome that is not Cushingâs disease can be also caused by high cortisol levels that result from tumors in other parts of the body.