M1, M3 and M5 receptors cause the activation of phospholipase C, generating two secondary messengers (IP3 and DAG) eventually leading to an intracellular increase of calcium, while M2 and M4 inhibit adenylate cyclase, thereby decreasing the production of the second messenger cAMP.
Keep your dog healthy and parvo-free with these 8 tips: Make sure your dog is properly vaccinated. Puppies should receive their first vaccines at 6-8 weeks of age; boosters should be administered at three-week intervals until the puppy is 16 weeks of age, and then again at one year of age. Previously vaccinated adult dogs need boosters every year.
A puppy has to be 6 weeks old to get a parvo shot and is needed every 3-4 weeks until they are 16 weeks old. After the puppy series they should be given once a year when they â¦ turn a year old.+ 24 others found this useful.DustinandKatie Ayers.sually this means getting BOOSTER shots at a later date. For example, a puppy could get a combination vaccine at 12 weeks of age, and boosters at 16 and 20 weeks of age. The puppy might also get it's first rabies vaccine at 12 weeks of age, and a booster shot a whole year later.