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Search form. Causes. The cause or causes of lymphoma are largely a mystery. There may be some genetic predisposition, or it may be caused by an environmental trigger such as pollution. There is not, however, sufficient evidence to provide a definitive answer.
For now, the best way to reduce the risk for non-Hodgkin lymphoma is to try to prevent known risk factors such as immune deficiency. Infection with the human immunodeficiency virus (HIV) is a preventable cause of immune deficiency.