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TRH stimulation test. Prior to the availability of sensitive TSH assays, thyrotropin releasing hormone (TRH) stimulation tests were relied upon for confirming and assessing the degree of suppression in suspected hyperthyroidism. Typically, this stimulation test involves determining basal TSH levels and levels 15 to 30 minutes after an intravenous bolus of TRH.
The TRH is carried down to the adenohypophysis by the hypothalamic portal veins where it releases TSH (Thyrotropin aka Thyroid Stimulating Hormone) and released into the blood stream where it stimulates the thyroid gland to release Thyroxin (T4) and T3 and as it increases in the blood stream, we go back to homeostasis.he TRH is carried down to the adenohypophysis by the hypothalamic portal veins where it releases TSH (Thyrotropin aka Thyroid Stimulating Hormone) and released into the blood stream where it stimulates the thyroid gland to release Thyroxin (T4) and T3 and as it increases in the blood stream, we go back to homeostasis.