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The main target organs where parathyroid hormone exerts its effects are the bones and the kidneys. When needed, parathyroid hormone is released by the parathyroid glands into the blood and causes the bones to release calcium and increase levels in the bloodstream.
The main use of sirolimus is in patients with a kidney transplant. It may be chosen because other immune suppressing drugs are causing side effects, or the patient is developing cancers associated with lowered immunity (including skin cancers).he mammalian target of rapamycin (mTOR) is a complex of protein kinases that promote cellular survival, cellular growth and catabolic processes. The mTOR pathway is inhibited by sirolimus/rapamycin. The mTOR pathway is also dysregulated in diabetes, obesity, some inflammatory skin diseases and certain cancers.