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A high white blood cell count may be caused by a wide range of conditions, which include normal physiological responses to stress, allergic reactions, infection and serious conditions such as cancer. Treatment usually depends on the cause or disease.
Certain medications, such as oral corticosteroids, also increase the white blood cell count. A low white blood cell count (leukopenia) is less common. Certain medications, infections, inflammatory and autoimmune conditions, heavy alcohol use, and problems in the bone marrow can cause a low white blood cell count.