1 Preheat the oven to 300 degrees F (150 degrees C).  Warm the au jus sauce in a saucepan over medium heat. Add the roast beef and let it warm up at the same time. While the meat is soaking, place the rolls on a baking sheet with the cut side down. Brush the tops lightly with water and sprinkle with salt and caraway seeds.
PK/PD models. PK/PD modeling (pharmacokinetic/pharmacodynamic modeling) (alternatively abbreviated as PKPD or PK-PD modeling) is a technique that combines the two classical pharmacologic disciplines of pharmacokinetics and pharmacodynamics.
pKb Definition. pKb is the negative base-10 logarithm of the base dissociation constant (Kb) of a solution. It is used to determine the strength of a base or alkaline solution. pKb = -log10Kb. The lower the pKb value, the stronger the base. As with the acid dissociation constant, pKa, the base dissociation constant calculation is an approximation that is only accurate in dilute solutions.