1 Preheat the oven to 300 degrees F (150 degrees C).  Warm the au jus sauce in a saucepan over medium heat. Add the roast beef and let it warm up at the same time. While the meat is soaking, place the rolls on a baking sheet with the cut side down. Brush the tops lightly with water and sprinkle with salt and caraway seeds.
PK/PD models. PK/PD modeling (pharmacokinetic/pharmacodynamic modeling) (alternatively abbreviated as PKPD or PK-PD modeling) is a technique that combines the two classical pharmacologic disciplines of pharmacokinetics and pharmacodynamics.
https://CRAN.R-project.org/view=Pharmacokinetics. The primary goal of pharmacokinetic (PK) data analysis is to determine the relationship between the dosing regimen and the body's exposure to the drug as measured by the nonlinear concentration time curve or related summaries (e.g. the area under the curve).