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Pituitary dependent hypercortisolism, more commonly known as Cushing's disease, is caused by a pituitary tumor (non-cancerous) that triggers excessive levels of the stress hormone cortisol.
Cushing syndrome is caused by an overgrowth of cells in the adrenal gland that produce cortisol. The tumor that results leads to overproduction of cortisol and increased drinking, eating, urination, and enlarged, distended abdomen, skull-like look to head. These tumors do not typically invade other tissues, remaining confined to an enlargement of their original area.