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TRH stimulation test. Prior to the availability of sensitive TSH assays, thyrotropin releasing hormone (TRH) stimulation tests were relied upon for confirming and assessing the degree of suppression in suspected hyperthyroidism. Typically, this stimulation test involves determining basal TSH levels and levels 15 to 30 minutes after an intravenous bolus of TRH.
Clinical Significance. Thyrotropin Releasing Hormone (TRH) is a tripeptide produced primarily by the hypothalamus. TRH is produced from a prohormone, which contains multiple copies of the TRH molecule meaning that several TRH entities can be released from one precursor.It has a stimulatory effect on the pituitary releasing thyrotropin (TSH).TRH secretion is controlled in a negative feedback system by thyroid hormones. Binding of TRH to its receptor causes a rise in calcium which initiates TSH secretion.linical Significance. Thyrotropin Releasing Hormone (TRH) is a tripeptide produced primarily by the hypothalamus. TRH is produced from a prohormone, which contains multiple copies of the TRH molecule meaning that several TRH entities can be released from one precursor.