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Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.n similar manner, older dopamine agonists used for Parkinson's disease such as bromocriptine and cabergoline are poorly selective for one dopamine receptor over another, and, although most of these agents do act as D 2 agonists, they affect other subtypes as well.
In contrast, D2-class dopamine receptors (D2, D3, and D4) are coupled to GÎ± i/o and negatively regulate the production of cAMP, resulting in a decrease in PKA activity (Kebabian and Greengard, 1971; Kebabian and Calne, 1979; Enjalbert and Bockaert, 1983; Missale et al., 1998).he D1- and D2-class dopamine receptors are also different at the level of genetic structure, primarily in the presence of introns in their coding sequences.