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Prevalance of Scleroderma: Estimates for the number of people in the United States with systemic sclerosis range from 40,000 to 165,000. By contrast, a survey that included all scleroderma-related disorders, including Raynaud's phenomenon, suggested a number between 250,000 and 992,500.bout prevalence and incidence statistics: The term 'prevalence' of Scleroderma usually refers to the estimated population of people who are managing Scleroderma at any given time.
The prognosis is generally good for limited cutaneous scleroderma persons who escape lung complications, but is worse for those with the diffuse cutaneous disease, particularly in older age and for males. Death occurs most often from lung, heart and kidney complications. In diffuse cutaneous disease, five-year survival is 70% and 10-year survival is 55%. The cause of scleroderma is unknown. It is an autoimmune condition, in which the body's immune system attacks healthy tissues. Strong associations with certain mutations in HLA genes have been identified.