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A high white blood cell count may be caused by a wide range of conditions, which include normal physiological responses to stress, allergic reactions, infection and serious conditions such as cancer. Treatment usually depends on the cause or disease.
A low white blood cell count usually is caused by one of the following: 1  Viral infections that temporarily disrupt bone marrow function. 2  Congenital disorders characterized by diminished bone marrow function. 3  Cancer or other diseases that damage bone marrow.