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A high white blood cell count may be caused by a wide range of conditions, which include normal physiological responses to stress, allergic reactions, infection and serious conditions such as cancer. Treatment usually depends on the cause or disease.
Quick Answer. Inadequate generation of red blood cells, platelets or white blood cells by the bone marrow can cause a low blood count. This can occur due to certain bone marrow diseases such as paroxysmal nocturnal hemoglobinuria, aplastic anemia and myelodysplastic syndromes, bleeding, and abnormal hemoglobin formation or red blood cell shape.