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A high white blood cell count may be caused by a wide range of conditions, which include normal physiological responses to stress, allergic reactions, infection and serious conditions such as cancer. Treatment usually depends on the cause or disease.
Symptoms are typically related to the cause of the high white blood cell count. 1  If the cause is an infection, symptoms will appear as fever, lack of appetite, moodiness, and fatigue. 2  If the cause is parasites, such as heartworm, symptoms are coughing, fatigue, and weight loss.