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A high white blood cell count may be caused by a wide range of conditions, which include normal physiological responses to stress, allergic reactions, infection and serious conditions such as cancer. Treatment usually depends on the cause or disease.
Quick Answer. Diseases that cause low white blood cell counts include aplastic anemia, human immunodeficiency virus, leukemia and lupus, according to Mayo Clinic. Other causes include rheumatoid arthritis, Crohn's disease and infections such as tuberculosis, reports MedlinePlus.