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A high white blood cell count may be caused by a wide range of conditions, which include normal physiological responses to stress, allergic reactions, infection and serious conditions such as cancer. Treatment usually depends on the cause or disease.
A high white blood cell count usually indicates: 1  An increased production of white blood cells to fight an infection. 2  A reaction to a drug that increases white blood cell production.pecific causes of high white blood cell count include: 1  Acute lymphocytic leukemia. 2  Acute myelogenous leukemia (AML). 3  Allergy, especially severe allergic reactions. 4  Chronic lymphocytic leukemia. 5  Chronic myelogenous leukemia. 6  Drugs, such as corticosteroids and epinephrine. 7  Myelofibrosis. 8  Certain bacterial infections.