Appendicitis occurs when the appendix becomes blocked, often by stool, a foreign body, or cancer. Blockage may also occur from infection, since the appendix swells in response to any infection in the body.
A familial generation is a group of living beings constituting a single step in the line of descent from an ancestor. In developed nations the average familial generation length is in the high 20s and has even reached 30 years in some nations.
God said to Abraham that after 400 years He would deliver Israel, ...in the fourth generation. A generation in the Bible is normally 40 years. However, here a generation is 100 years (4 * 100 = 400 years).