Appendicitis occurs when the appendix becomes blocked, often by stool, a foreign body, or cancer. Blockage may also occur from infection, since the appendix swells in response to any infection in the body.
A familial generation is a group of living beings constituting a single step in the line of descent from an ancestor. In developed nations the average familial generation length is in the high 20s and has even reached 30 years in some nations.
Quite a difference when counting over hundreds or thousands of years. Today, in our secular world, a generation may be as short as 18 years like the 'baby boomers' (1946-1964) and as long as the frequent 100 years - the most common time is 40 years. Final thought, the term  generation  may have other meanings too.