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Pituitary dependent hypercortisolism, more commonly known as Cushing's disease, is caused by a pituitary tumor (non-cancerous) that triggers excessive levels of the stress hormone cortisol.
Pseudo-Cushing's syndrome is a medical condition in which patients display the signs, symptoms, and abnormal hormone levels seen in Cushing's syndrome. Another cause for Cushing's syndrome is the extremely rare form of cancer (Adrenal Cortisol Carcinoma), when a benign lesion on the adrenal gland (which would cause Cushing's) becomes malignant and starts producing its own cortisol.