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Pituitary dependent hypercortisolism, more commonly known as Cushing's disease, is caused by a pituitary tumor (non-cancerous) that triggers excessive levels of the stress hormone cortisol.
You can also get Cushing's syndrome because your body makes too much cortisol. A tumor in your pituitary gland that makes extra ACTH, and that causes the adrenal glands to make more cortisol. This is called Cushing's disease. These tumors usually aren't cancer. A tumor in your lung or pancreas that makes ACTH, and that causes the adrenal glands to make more cortisol. Sometimes these tumors are cancer. A tumor in your adrenal glands that makes extra cortisol. Some of these tumors are cancer.