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Numerous experimental observations suggest that local factors play a major role in the pathophysiology of restenosis. Angioplasty is invariably associated with arterial injury that provides a potent stimulus for both platelet adhesion and platelet aggregation.umerous experimental observations suggest that local factors play a major role in the pathophysiology of restenosis. Angioplasty is invariably associated with arterial injury that provides a potent stimulus for both platelet adhesion and platelet aggregation.
DESCRIPTION: When percutaneous transluminal coronary angioplasty (PTCA) is performed to open a partially blocked artery, the rate of restenosis within a six-month period is 30% to 50%. When a metal stent is inserted to keep the vessel open, in-stent restenosis occurs in about 20% of the cases. Those with additional conditions such as diabetes have an even higher risk for in-stent restenosis.