1 Preheat the oven to 300 degrees F (150 degrees C).  Warm the au jus sauce in a saucepan over medium heat. Add the roast beef and let it warm up at the same time. While the meat is soaking, place the rolls on a baking sheet with the cut side down. Brush the tops lightly with water and sprinkle with salt and caraway seeds.
PK/PD models. PK/PD modeling (pharmacokinetic/pharmacodynamic modeling) (alternatively abbreviated as PKPD or PK-PD modeling) is a technique that combines the two classical pharmacologic disciplines of pharmacokinetics and pharmacodynamics.
In chemistry, pK is the logarithmic value of the dissociation constant, Ka, of a hydrogen atom present on a molecule. A molecule has a distinct pK for each hydrogen atom that can be deprotonated. The acidity of a specific hydrogen atom in a molecule is represented by the pK value. Continue Reading.