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A: According to MedicineNet, a low granulocyte count can be caused by bacterial or viral infections, certain cancers, chemotherapy drugs, radiation treatment or certain autoimmune disorders. A low granulocyte count can also occur in healthy people without any known cause. Granulocytes are immune cells that are filled with toxic granules.
Eosinophilic granulocytes are mostly located in tissues, and not in the peripheral blood. They are produced in the bone marrow. Before moving to tissues they remain in the peripheral blood for about 10 hours. Eosinophilia accompanies immune and allergic reactions. Eosinophilic granulocytes have antihistaminic function, so by eliminating histamine they prevent its activities available for producing edema and smooth muscles spasm. They have power of phagocytosis, but in that ability they are far behind neutrophilis.