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Natural killer cells or NK cells are a type of cytotoxic lymphocyte critical to the innate immune system.his role of NK cells is critical to immune success particularly because T cells are unable to recognize pathogens in the absence of surface antigens. Tumor cell detection results in activation of NK cells and consequent cytokine production and release.
Fron NK cells to innate lymphoid cells. In the course of recent work on the NKp46 receptor, one of the characteristic molecules of NK cells in humans and mice, the team was involved in the discovery of a new world of lymphocytes: that of the innate lymphoid cells (ILCs). These cells seem to be the innate equivalent of T lymphocytes. NK cells are natural members of this new category, and they express the NKp46 receptor at their surface, just like two subpopulations of ILCs (ILC1 and ILC3) present in the liver and intestine, respectively.