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Natural killer cells or NK cells are a type of cytotoxic lymphocyte critical to the innate immune system.his role of NK cells is critical to immune success particularly because T cells are unable to recognize pathogens in the absence of surface antigens. Tumor cell detection results in activation of NK cells and consequent cytokine production and release.
However, many clinicians lose perspective of this important system with all of the nomenclature unique to this system. What follows is a clinician-oriented overview of natural killer (NK) cells and macrophages, two important components of the immune system. This group of cells is divided into many families based on their structures, like interferons (IFN), interleukins (IL), tumor necrosis factor (TNF), transformation growth factor (TGF), and chemokines.