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Pituitary dependent hypercortisolism, more commonly known as Cushing's disease, is caused by a pituitary tumor (non-cancerous) that triggers excessive levels of the stress hormone cortisol.
Identifying the cause of Cushingâs disease is important because the various types are treated differently and each has a different prognosis. Pituitary gland tumor. The most common cause of Cushing's disease (85% to 90% of all cases) is a tumor of the pituitary gland (which is located at the based of the brain). The tumor may be either benign or malignant. The tumor causes the pituitary gland to overproduce a hormone (ACTH) that stimulates the adrenal glands to produce cortisol.