1 Preheat the oven to 300 degrees F (150 degrees C).  Warm the au jus sauce in a saucepan over medium heat. Add the roast beef and let it warm up at the same time. While the meat is soaking, place the rolls on a baking sheet with the cut side down. Brush the tops lightly with water and sprinkle with salt and caraway seeds.
PK/PD models. PK/PD modeling (pharmacokinetic/pharmacodynamic modeling) (alternatively abbreviated as PKPD or PK-PD modeling) is a technique that combines the two classical pharmacologic disciplines of pharmacokinetics and pharmacodynamics.
Definition of pK. pK is a negative logarithmic scale of any rate constant. One of the most important examples of pK is pK a, the scale of relative acid strength. pK a is the negative log of the acid dissociation constant (pKa=-log([A-][H+]/[HA])).The Henderson-Hasselbalch equation relates pK a and pH to the relative concentrations of an acid and conjugate base in solution (pH=pKa+log([A-]/[HA])) .ne of the most important examples of pK is pK a, the scale of relative acid strength.