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pepsinogen. a zymogen secreted by the chief cells of the gastric glands and converted into pepsin in the presence of gastric acid or of pepsin itself.plasma pepsinogen. high levels are indicative of extensive mucosal damage in the abomasum, as in ostertagiasis in ruminants. proenzyme formed and secreted by the chief cells of the gastric mucosa; the acidity of the gastric juice and pepsin itself remove 42 amino acid residues from pepsinogen to form active pepsin. Synonym(s): propepsin. [ pepsin + G. -gen, producing].
Pepsinogen I is secreted by chief cells, and pepsinogen II is secreted by pyloric glands. The secretion of pepsinogen is stimulated by vagal stimulation, gastrin, and histamine. Pepsinogen I is mainly found in the body of the stomach, where most acid is secreted. Pepsin is a proteolytic enzyme, whereas pepsinogen is a proenzyme. â¢ Pepsin is the active form of pepsinogen while pepsinogen is the inactive precursor of pepsin. â¢ Unlike the pepsin, pepsinogen is secreted by chief cells and pyloric glands.