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Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.n similar manner, older dopamine agonists used for Parkinson's disease such as bromocriptine and cabergoline are poorly selective for one dopamine receptor over another, and, although most of these agents do act as D 2 agonists, they affect other subtypes as well.
Abstract. Dopamine D2-autoreceptors play a key role in regulating the activity of dopamine neurons and control the synthesis, release and uptake of dopamine. These G i/o-coupled inhibitory receptors play a major part in shaping dopamine transmission.2-autoreceptors also regulate dopamine transmission by increasing the activity of DAT (Cass and Gerhardt, 1994, Dickinson et al., 1999, Mayfield and Zahniser, 2001, Schmitz et al., 2002, Wu et al., 2002 and Benoit-Marand et al., 2011).