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pepsinogen. a zymogen secreted by the chief cells of the gastric glands and converted into pepsin in the presence of gastric acid or of pepsin itself.plasma pepsinogen. high levels are indicative of extensive mucosal damage in the abomasum, as in ostertagiasis in ruminants. proenzyme formed and secreted by the chief cells of the gastric mucosa; the acidity of the gastric juice and pepsin itself remove 42 amino acid residues from pepsinogen to form active pepsin. Synonym(s): propepsin. [ pepsin + G. -gen, producing].
One of the important products of gastric juice that is secreted by these cells is pepsin. Pepsin is the chief digestive enzyme in the stomach that breaks down proteins. You can think of pepsin as the 'chief' digestive enzyme in the stomach because it is produced by the chief cells.This can help you remember the term, but I should clarify that pepsin is the active protein-digesting enzyme.The chief cells actually produce pepsinogen (an inactive form of pepsin).ucus that is produced by the epithelial cells of the stomach help protect the lining of the stomach from the corrosive hydrochloric acid and pepsin. If this protective lining fails, it can result in a peptic ulcer, which is a lesion of the mucosa.