1 Preheat the oven to 300 degrees F (150 degrees C).  Warm the au jus sauce in a saucepan over medium heat. Add the roast beef and let it warm up at the same time. While the meat is soaking, place the rolls on a baking sheet with the cut side down. Brush the tops lightly with water and sprinkle with salt and caraway seeds.
PK/PD models. PK/PD modeling (pharmacokinetic/pharmacodynamic modeling) (alternatively abbreviated as PKPD or PK-PD modeling) is a technique that combines the two classical pharmacologic disciplines of pharmacokinetics and pharmacodynamics.
Pharmacokinetics, sometimes abbreviated as PK (from Ancient Greek pharmakon drug and kinetikos moving, putting in motion; see chemical kinetics), is a branch of pharmacology dedicated to determining the fate of substances administered externally to a living organism.harmacokinetics is often studied in conjunction with pharmacodynamics, the study of a drug's pharmacological effect on the body. A number of different models have been developed in order to simplify conceptualization of the many processes that take place in the interaction between an organism and a drug.