Appendicitis occurs when the appendix becomes blocked, often by stool, a foreign body, or cancer. Blockage may also occur from infection, since the appendix swells in response to any infection in the body.
A familial generation is a group of living beings constituting a single step in the line of descent from an ancestor. In developed nations the average familial generation length is in the high 20s and has even reached 30 years in some nations.
Generation has many meanings, with different values. None of them are exact. 27 - 35 for The average age in my family between parents and children. That is, if the parents were the same age and had children at age 24, 28, 30 and 32, the generation for them would be 29 years.