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A high white blood cell count may be caused by a wide range of conditions, which include normal physiological responses to stress, allergic reactions, infection and serious conditions such as cancer. Treatment usually depends on the cause or disease.
Specific causes of low white blood cell count include: 1  Aplastic anemia. 2  Certain medications, such as antibiotics and diuretics. 3  Chemotherapy. 4  HIV/AIDS. 5  Hypersplenism, a premature destruction of blood cells by the spleen. 6  Infectious diseases. 7  Kostmann's syndrome, a congenital disorder involving low neutrophil production. 8  Leukemia.