In addition to the purchase price of a property in France, and the various expenses, commissions, and taxes that that purchase entails, there is a further series of outlays that will arise out of your purchase.
When an enzyme binds its substrate, it forms an enzyme-substrate complex. This complex lowers the activation energy of the reaction and promotes its rapid progression by providing certain ions or chemical groups that actually form covalent bonds with molecules as a necessary step of the reaction process.
They work in the lock and key manner with a substrate. Each enzyme has it's own optimal Ph that allows it to lock in with the substrate and perform it's function as a catalyst. The optimal pH allows this reaction between the enzyme and substrates to be continue. In other words the reaction can be reversible. The enzyme can continue locking with a substrate and continue it's catalysts activity. If the pH is too high or too low it can change the shape of the enzyme. The ionic bonds that hold the shape of the enzyme are broken changing the 3D shape of the enzyme.