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The main target organs where parathyroid hormone exerts its effects are the bones and the kidneys. When needed, parathyroid hormone is released by the parathyroid glands into the blood and causes the bones to release calcium and increase levels in the bloodstream.
Although its primary target is the liver, glucagon (like epinephrine) also affects adipose tissue, activating triacylglycerol lipase by causing its cAMP-dependent phosphorylation. This lipase liberates free fatty acids, which are exported to the liver and other tissues as fuel, thus sparing glucose for the brain.