Appendicitis occurs when the appendix becomes blocked, often by stool, a foreign body, or cancer. Blockage may also occur from infection, since the appendix swells in response to any infection in the body.
A familial generation is a group of living beings constituting a single step in the line of descent from an ancestor. In developed nations the average familial generation length is in the high 20s and has even reached 30 years in some nations.
In general, cohorts range from 10 to 20-plus years. The other way to think about it is in terms of historical epochs. How long is a period of history dominated by one so-called generation of people. Depending on the author or discipline, this can range from 50 to 80 years. When I think about generational epochs, I rely on the Gettysburg Address!