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A high white blood cell count may be caused by a wide range of conditions, which include normal physiological responses to stress, allergic reactions, infection and serious conditions such as cancer. Treatment usually depends on the cause or disease.
Rating Newest Oldest. Best Answer: Usually the cause of high white blood cell count is *** simple as some type of infection in your body. The white blood cells are considered disease fighting cells and try to fend off any infection that you might have.