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Search form. Causes. The cause or causes of lymphoma are largely a mystery. There may be some genetic predisposition, or it may be caused by an environmental trigger such as pollution. There is not, however, sufficient evidence to provide a definitive answer.
Lymphomas are cancers of the white blood cells called lymphocytes, part of the body's immune system. In lymphoma, the lymphocytes morph into a cancer cell and accumulate in the lymph nodes and lymphatic system, where they crowd out normal lymphocytes. The two main types of lymphomas are Hodgkin's lymphoma and Non-Hodgkin's lymphoma. Hodgkin's and Non-Hodgkin's lymphomas affect different lymphocytes, so the treatment options and the course of the disease may differ.