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Numerous experimental observations suggest that local factors play a major role in the pathophysiology of restenosis. Angioplasty is invariably associated with arterial injury that provides a potent stimulus for both platelet adhesion and platelet aggregation.umerous experimental observations suggest that local factors play a major role in the pathophysiology of restenosis. Angioplasty is invariably associated with arterial injury that provides a potent stimulus for both platelet adhesion and platelet aggregation.
Restenosis is the name given to the condition in which the artery treated with angioplasty begins to close. This can happen even when a stent is in place. Restenosis can cause chest pain in the patient when the patient exerts himself or herself. The treatment for restenosis is usually a repeat surgery. If the chest pain increases or is at the site of the procedure, the doctor should be contacted immediately.