In our case series, the prognostic relevance of single markers was only observed for tumor and stromal expression of HIF-1α in the G3 subgroupand for stromal HJURP expression in G1-2 lesions.
The odds ratio analysis of these markers highlighted two immunohistochemical cut-off values for stromal HJURP and HIF-1α that identified patients with a sevenfold and tenfold higher risk of relapse, respectively.