In the presence of Na +, glutamine and serine showed the strongest inhibitory effect against anti- [14C] FACBC uptake, suggesting that system ASC, especially ASCT2, is an important AAT for anti- [14C] FACBC.
Phenylalanine and 2-amino-bicyclo [2,2,1] heptane-2-carboxylic acid, but not N-ethylmaleimide, almost completely inhibited the anti- [14C] FACBC uptake in the absence of Na +, indicating the contribution of LAT1.