Conversely, co-treating oocytes with SW solutions of such AMPK agonists plus cAMP elevators restores AMPK deactivation and allows GVBD to occur [74].
These findings indicate that active AMPK normally blocks nemertean GVBD and that cAMP elevators can downregulate AMPK via a mechanism that is independent of the AMPK-deactivating pathway (s) elicited by SW.