[ Show abstract] [Hide abstract] ABSTRACT: The metabolism of α, β-unsaturated aldehydes, e.g. , 4-hydroxynonenal, involves oxidation to carboxylic acids, reduction to alcohols, and glutathionylation to eventually form mercapturide conjugates.
we demonstrated that p450s can oxidize aldehydes to carboxylic acids, a reaction previously thought to involve aldehyde dehydrogenase.