As NuA4 acetylates the histone H2A variant Htz1, we also examined Cdc11-GFP localization in cells lacking HTZ1 and discovered these cells were indistinguishable from their wild type counterpart (data not shown).
These data indicate that the role of NuA4 in septin dynamics occurs independently from its primary histone acetylation targets, potentially through the acetylation of non-histone proteins.