Our findings thus suggest that the Mst1-FoxO-Sod2/catalase pathway might tightly modulate intracellular ROS in CD4 + and CD8 + T cells to maintain levels optimal for cell survival.
Two recent studies showed that FoxO1 is critical for the maintenance of naïve T cell homeostasis by controlling the expression of IL-7Rα, L-selectin, and CCR7 [4], [5].