However, MALS TKO mutant brains showed no alteration in aPKC staining, suggesting that MALS-3 is not required for the normal localization of the PAR3/PAR6/aPKC complex.
These results suggest that, although a loss of MALS-3 is tolerated by NPCs, its mislocalization is not, with mislocalization causing far more detrimental effects on apical polarity.