VEGF165, the major angiogenic growth factor, is known to activate various steps in proangiogenic endothelial cell behavior, such as endothelial cell migration and invasion, or endothelial cell survival.
the urokinase-type plasminogen activator (upa) -system has been shown to play an essential role not only by its proteolytic capacities, but also by induction of intracellular signal transduction.