Untreated mortality is >90%
Similar clinical symptoms but different pathophysiology than HUS
HUS more common in pediatrics
Microangiopathic Hemolytic Anemia (MAHA) + low Platelets is<unk>  until proven otherwise
MAHA is non-immune hemolysis (Coomb's-negative hemolysis) causing RBC fragmentation producing schistocytes
Can occur as a result of Plavix (clopidogrel) use, especially within the first 2 weeks
HUS more common in pediatrics
MAHA is non-immune hemolysis (Coomb's-negative hemolysis) causing RBC fragmentation producing schistocytes
Insufficient ADAMTS-13 activity allows vWF multimers to accumulate in microcirculation which leads to platelet aggregation/thrombocytopenia and hemolysis of RBCs.  Platelet clots are transient, but the symptoms especially neuro, can be in flux.
Congenitally deficient ADAMTS-13 activity AND:
Pregnancy OR
Infection OR
Inflammation OR
Medication use (quinolones, ticlopidine, clopidogrel)
Pregnancy OR
Infection OR
Inflammation OR
Medication use (quinolones, ticlopidine, clopidogrel)
Thrombotic thrombocytopenic purpura
Other MAHAs 
Immune thrombocytopenic purpura
ITP
Disseminated intravascular coagulation
Sepsis
Heparin-Induced Thrombocytopenia 
SLE