Half-life: 2-4 hr
Metabolism: Metabolized in liver b CYP3A4 (first pass)
Excretion: urine (60%), feces (35%)
Mechanism of Action:
inhibits trasmembrane influx of extracellular calcium ions across membranes of myocardial cells and vascular smooth muscle cells without changing serum calcium concentrations; this inhibit cardiac and vascular smooth muscle contractions, thereby dilating maincoronary and systemic arteries.
inhibits trasmembrane influx of extracellular calcium ions across membranes of myocardial cells and vascular smooth muscle cells without changing serum calcium concentrations; this inhibit cardiac and vascular smooth muscle contractions, thereby dilating maincoronary and systemic arteries.
Nicardipine
Nitroprusside
Esmolol
Nitroglycerin
Atenolol
Sotalol
Labetalol
Metoprolol