<unk><unk><unk> s (MAOI)
Used to treat depression and Parkinsonism
MAOI drugs available in the US include:
Isocarboxazid, phenelzine (Nardil), tranylcypromine (Parnate)
Selegiline (Deprenyl, Eldepryl, Emsam, Zelapar)--> MAO-B at lower doses, MAO-A at higher doses, rasagiline (Azilect), safinamide (Xadago)
Linezolid is a reversible<unk>  of MAO and produces significant inhibition of MAO-A
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Lead to increased norepinephrine, serotonin, dopamine, tyramine
Isocarboxazid, phenelzine (Nardil), tranylcypromine (Parnate)
Selegiline (Deprenyl, Eldepryl, Emsam, Zelapar)--> MAO-B at lower doses, MAO-A at higher doses, rasagiline (Azilect), safinamide (Xadago)
Linezolid is a reversible<unk>  of MAO and produces significant inhibition of MAO-A
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Intentional overdose
Symptoms often delayed 6-24 hours after ingestion
Food-drug interactions
Taking MAOI at therapeutic doses, but inadvertently eating foods rich in tyramine (aged cheese, red wine, aged meats)
Symptoms are generally acute
Drug-drug interactions
Many prescription and OTC medications interact with MAOI
Symptoms often delayed 6-24 hours after ingestion
Taking MAOI at therapeutic doses, but inadvertently eating foods rich in tyramine (aged cheese, red wine, aged meats)
Symptoms are generally acute
Many prescription and OTC medications interact with MAOI
MAO-A
Primarily deaminates serotonin and norepinephrine
MOA-B
Primarily deaminates phenylethylamine
Primarily deaminates serotonin and norepinephrine
Primarily deaminates phenylethylamine
Monoamine oxidase inhibitor toxicity
Intoxications
Synthetic cathinone toxicity
Amphetamines
Tricyclic antidepressant toxicity
Antimuscarinics
Mescaline toxicity
Methylxanthine toxicity 