Treatment = desmopressin, cryoprecipitate, conjugated estrogen, EPO, dialysis
Limited evidence for dialysis (peritoneal vs. hemodialysis) in management of acute<unk><unk> 
DDAVP 0.4 mcg/kg IV over 10 min - effects within 1 hr but increased<unk>  time returns within 24 hrs
Cryoprecipitate 10 bags over 30 min - benefit seen within 4-12 hrs in most
Recombinant EPO 50 - 150 u/kg IV 3x/wk
Conjugated estrogens at 0.6mg/kg IV over 30 min QD for 5 days - time to effect ~ 6 hrs, max effect at 1 wk, duration of action 2 wks
Limited evidence for dialysis (peritoneal vs. hemodialysis) in management of acute<unk><unk> 
DDAVP 0.4 mcg/kg IV over 10 min - effects within 1 hr but increased<unk>  time returns within 24 hrs
Cryoprecipitate 10 bags over 30 min - benefit seen within 4-12 hrs in most
Recombinant EPO 50 - 150 u/kg IV 3x/wk
Conjugated estrogens at 0.6mg/kg IV over 30 min QD for 5 days - time to effect ~ 6 hrs, max effect at 1 wk, duration of action 2 wks

pRBCs
Raising HCT to above 25-30% improves<unk>  time
Raising HCT to above 25-30% improves<unk>  time
Simplest and least toxic acute treatment
Increases release of factor VIII:von Willebrand factor multimers
0.3 mcg/kg IV (preferred) or SC (max 20mg). 3mcg/kg intranasaly is an option.
Onset of action ~1hr, duration of action ~4-24hr
Unclear mechanism of action
Onset of action within 1d
Options
Conjugated estrogen 0.6mg/kg IV or 2.5-25mg PO daily
Conjugated estrogen 0.6mg/kg IV or 2.5-25mg PO daily
Only indicated for life-threatening<unk>  resistant to DDAVP and blood tranfusion
10 bags over 30 minutes
Minimally effective because infused platelets quickly acquire the<unk>  defect
Only use when uncontrolled hemorrhage
Gelatin - Gelfoam or Surgifoam
Thrombin - Floseal
Uremic bleeding syndrome
Dialysis filter may cause thrombocytopenia
Heparin-Induced Thrombocytopenia 
Too few
Hyperviscosity syndrome
Thrombocytopenia
Liver disease induced coagulopathy
Nonfunctional