Clinical presentation will depend on if unilateral or bilateral
Unilateral
Typically present later in life
Commonly with purulent nasal discharge and obstruction on the affected side and/or a history of chronic sinusitis
Rarely will present with respiratory distress
Typically present later in life
Commonly with purulent nasal discharge and obstruction on the affected side and/or a history of chronic sinusitis
Rarely will present with respiratory distress
Bilateral
Typically will present in early life with episodes of acute respiratory distress with cyanosis that is relieved with crying and with the return of cyanosis with rest (paradoxical cyanosis)
May present with feeding difficulty, as they are unable to breathe and feed simultaneously
Typically will present in early life with episodes of acute respiratory distress with cyanosis that is relieved with crying and with the return of cyanosis with rest (paradoxical cyanosis)
May present with feeding difficulty, as they are unable to breathe and feed simultaneously
May be an isolated anomaly or associated with a congenital anomaly syndrome (e.g. Treacher-Collins, CHARGE, VACTERL/VATER, Pfeiffer)
Other congenital anomalies are in present in 50% of individuals with unilateral<unk>  and 60% of individuals with bilateral<unk>
Choanal atresia
Deviated or dislocated nasal septum
Duodenal atresia
Nasal septal hematoma
Branchial cleft anomaly
Nasal polyp
Hirschsprung's disease
Chordoma