Many patients are asymptomatic
At onset of symptoms: fever, dry cough, myalgias, fatigue, shortness of breath
Fever and cough start early, shortness of breath noted about 9 days into illness
Fever not present in all adults
Only 1/2 of patients may have fever at time of admission
less common in vulnerable populations
Less common: cough with sputum, sore throat, headache, congestion, GI symptoms, anosmia, altered mental status
Sudden onset anosmia has a high specificity for<unk>  infection
Fever and cough start early, shortness of breath noted about 9 days into illness
Fever not present in all adults
Only 1/2 of patients may have fever at time of admission
less common in vulnerable populations
Less common: cough with sputum, sore throat, headache, congestion, GI symptoms, anosmia, altered mental status
Sudden onset anosmia has a high specificity for<unk>  infection
Only 1/2 of patients may have fever at time of admission
less common in vulnerable populations
The initial presentation can be followed by delayed and serious complications
Pulmonary
Most common complications: pneumonia, ARDS (average 8 days from onset, 20% of patients in China)
"Happy Hypoxemia": many of these patients will be hypoxic without dyspnea
Decompensation risk occurs during 2nd week of illness leading to respiratory failure
Cardiac Complications
Myocarditis,Acute Myocardial infarction, Dysrhythmias, cardiomyopathy, venous thromboembolism.
Vasodilatory shock reported in 67% of ICU admissions
Cardiomyopathy reported in 33% of ICU admissions
Mortality reported 67% of ICU admissions
Neurological Complications- thought to be related to the increased levels of interleukin (IL)-6, IL-12, IL-15, and tumor necrosis factor alpha (TNF-α)
acute CVA, encephalitis, Guillain-Barré syndrome, acute necrotizing hemorrhagic encephalopathy, and hemophagocytic lymphohistiocytosis
Most common complications: pneumonia, ARDS (average 8 days from onset, 20% of patients in China)
"Happy Hypoxemia": many of these patients will be hypoxic without dyspnea
Decompensation risk occurs during 2nd week of illness leading to respiratory failure
Myocarditis,Acute Myocardial infarction, Dysrhythmias, cardiomyopathy, venous thromboembolism.
Vasodilatory shock reported in 67% of ICU admissions
Cardiomyopathy reported in 33% of ICU admissions
Mortality reported 67% of ICU admissions
Vasodilatory shock reported in 67% of ICU admissions
Cardiomyopathy reported in 33% of ICU admissions
Mortality reported 67% of ICU admissions
acute CVA, encephalitis, Guillain-Barré syndrome, acute necrotizing hemorrhagic encephalopathy, and hemophagocytic lymphohistiocytosis
COVID-19
Influenza
Rubella
URI
Anthrax
Pneumonia
H1N1 
Sinusitis