Fever: temperature >38.9°C
Rash: diffuse macular erythroderma
Hypotension: systolic blood pressure <90 mm Hg (adults) or <5th percentile for age (children younger than 16 years), or orthostatic hypotension, dizziness, or syncope
Multisystem dysfunction: at least 3:
Gastrointestinal: vomiting or diarrhea at onset of illness
Muscular: severe myalgias, or serum creatine phosphokinase level (CPK) greater than twice the upper limit of normal
Mucous membranes: vaginal, oropharyngeal, or conjunctival hyperemia
Renal: blood urea nitrogen or creatinine level greater than twice the upper limit of normal, or pyuria (5 leukocytes per high-power field), in the absence of urinary tract infection
Hepatic: total serum bilirubin or transaminase level greater than twice the upper limit of normal
Hematologic: platelets <100,000/L
Central nervous system: disorientation or alteration in consciousness but no focal neurologic signs at a time when fever and hypotension are absent.
Desquamation: One to 2 weeks after the onset of illness (typically palms and soles)
Gastrointestinal: vomiting or diarrhea at onset of illness
Muscular: severe myalgias, or serum creatine phosphokinase level (CPK) greater than twice the upper limit of normal
Mucous membranes: vaginal, oropharyngeal, or conjunctival hyperemia
Renal: blood urea nitrogen or creatinine level greater than twice the upper limit of normal, or pyuria (5 leukocytes per high-power field), in the absence of urinary tract infection
Hepatic: total serum bilirubin or transaminase level greater than twice the upper limit of normal
Hematologic: platelets <100,000/L
Central nervous system: disorientation or alteration in consciousness but no focal neurologic signs at a time when fever and hypotension are absent.
Hypotension: systolic blood pressure <90 (adult) or <5th percentile for age (children younger than 16 years)
Multiorgan involvement(>2 organ systems):
Skin: generalized erythematous macular rash that may desquamate
Soft tissue necrosis, including necrotizing fascitis or myositis, or gangrene
Acute respiratory distress syndrome: acute onset of diffuse pulmonary infiltrates and hypoxemia in absence of cardiac failure or by evidence of diffuse capillary leak by acute onset of generalized edema, or pleural or peritoneal effusions with hypoalbuminemia.
Hepatic: total bilirubin, ALT, or AST >2 times the upper limit of normal for the patient's age. x2 elevation in patients with per-existing liver disease.
Renal: serum creatinine >2 milligrams/dL( >177umol/L) for adults or >2 times the upper limit of normal for age. x2 fold increase in creatitine elevation from baseline
Coagulopathy: platelet count <100,000/mm3 or DIC.
Skin: generalized erythematous macular rash that may desquamate
Soft tissue necrosis, including necrotizing fascitis or myositis, or gangrene
Acute respiratory distress syndrome: acute onset of diffuse pulmonary infiltrates and hypoxemia in absence of cardiac failure or by evidence of diffuse capillary leak by acute onset of generalized edema, or pleural or peritoneal effusions with hypoalbuminemia.
Hepatic: total bilirubin, ALT, or AST >2 times the upper limit of normal for the patient's age. x2 elevation in patients with per-existing liver disease.
Renal: serum creatinine >2 milligrams/dL( >177umol/L) for adults or >2 times the upper limit of normal for age. x2 fold increase in creatitine elevation from baseline
Coagulopathy: platelet count <100,000/mm3 or DIC.
Toxic shock syndrome
Positive Nikolsky’s sign
Drug fever
Febrile
Lemierre's syndrome
Staphylococcal scalded skin syndrome 
Acute tetanus
Toxic epidermal necrolysis/SJS 