The condition is benign and does not require treatment but many patients have concerns about the aesthetic appearance.
Foundation of treatment is aimed at workup and management of the often underlying concomitant immunocompromised disease process.
High dose acyclovir can be used (4g/day), but relief is temporary and often lesions recur until immunocompromised status is reversed
Hairy oral leukoplakia
Tongue laceration
Herpes gingivostomatitis
Strawberry tongue
Black hairy tongue
Condyloma acuminata
Oropharyngeal candidiasis 
Exotic pet infections