Staphylococcal (Staph aureus) and Streptococcal (Type A strep: Step. pyogenes) types
1-2/100,000 cases/year
S. aureus strain that produces<unk>  toxin-1 (superantigen) is the most common cause
GAS is a less common cause
Superantigens stimulate T-cell proliferation independent of antigen-specific binding → massive cytokine production
Also affect neutrophil chemotaxis suppression and blockage of reticuloendothelial system
GAS is a less common cause
Also affect neutrophil chemotaxis suppression and blockage of reticuloendothelial system
Postop patients
Nasal packing
Abscess
Burns
Tampon use
IUDs
Toxic shock syndrome
Positive Nikolsky’s sign
Drug fever
Febrile
Lemierre's syndrome
Staphylococcal scalded skin syndrome 
Acute tetanus
Toxic epidermal necrolysis/SJS 