Fatal intoxications are rare and estimates suggest 60mg - 500mg as a lethal dose.  Traditional<unk>  deliver approximately 2mg of nicotine 
Absorbed transdermally, orally and via inhalation
Initially excitation secondary to excitation of the presynaptic nAChR which facilitates release of neurotransmitters
Second phase characterized by desensitization of the receptors and decreased neurotransmitter release
Electronic cigarettes
Anticholinergic Toxicity
Dirty bomb
Organophosphate Toxicity
Hazmat exposure
Sympathomimetic Toxicity
Caustic cocktail
Neuroleptic Malignant Syndrome 