Patients with focal findings may have surgically treatable cause
Coma cocktail
Glucose, thiamine, naloxone
Treat underlying cause
Glucose, thiamine, naloxone
Altered mental status
Hypoxic encephalopathy
Sedation 
Acute toxic-metabolic encephalopathy 
Extrapyramidal reaction
Hypoglycemia
Tremor
Hyperosmolar state 