Pharmacokinetics
Onset of action = 45-90s
Duration of action = 10-20min (antiarrythmic IV); 30-90 min (subcutaneous)
Half-life 90 - 120 minutes
Prolonged in hepatic impairment or congestive heart failure
Metabolism
Primarily hepatic
Excretion
Urine
Mechanism of Action
Class Ib antiarrythmic
Binds to fast Na channels in inactive state thereby raising the depolarization threshold
Acts preferentially on ischemic tissue
Elevates V-fib threshold
Suppresses ventricular ectopy
Little effect on vascular tone, contractility, or cardiac output
Onset of action = 45-90s
Duration of action = 10-20min (antiarrythmic IV); 30-90 min (subcutaneous)
Half-life 90 - 120 minutes
Prolonged in hepatic impairment or congestive heart failure
Prolonged in hepatic impairment or congestive heart failure
Primarily hepatic
Urine
Class Ib antiarrythmic
Binds to fast Na channels in inactive state thereby raising the depolarization threshold
Acts preferentially on ischemic tissue
Elevates V-fib threshold
Suppresses ventricular ectopy
Little effect on vascular tone, contractility, or cardiac output
Binds to fast Na channels in inactive state thereby raising the depolarization threshold
Acts preferentially on ischemic tissue
Elevates V-fib threshold
Suppresses ventricular ectopy
Elevates V-fib threshold
Suppresses ventricular ectopy
Lidocaine
Quinidine
Prilocaine
Flecainide
Procainamide
Lofexidine
Propafenone
Ibutilide