Half-life: 11 to 13 hours (first dose), 17 to 22 hours (steady state)
Metabolism: First pass associated with gut absorption, hepatic via CYP2D6 (primary), CYP1A2, and CYP2C19
Excretion: Urine (94%), Feces (1%)
Lofexidine
Propafenone
Procainamide
Verapamil
Lidocaine
Flecainide
Encainide
Riociguat