Muscle necrosis and release of intracellular muscle constituents into the circulation
Recurrent episodes suggests inherited metabolic disorder
Alcohol and drugs play a role in up to 80% of cases
Trauma or muscle compression
Crush Syndrome
Immobilization
Compartment Syndrome
Nontraumatic Exertional
Exercise + hot weather
Exercise + sickle cell
Exercise + Hypokalemia
Hyperkinetic states
Seizure
DTs
Stimulant / Sympathomimetic overdose
Malignant Hyperthermia
Neuroleptic malignant syndrome
Nontraumatic Nonexertional
Drugs and toxins
Coma induced by sedatives
Alcohol
Coma-induced muscle compression
Direct toxic effect
Nutritional compromise increases risk (hypoK, hypoMg, hypoPhos)
Statins
Colchicine
CO Poisoning
Infection
Viral myositis - influenza, coxsackie, EBV, HSV, HIV, CMV
Bacterial pyomyositis
Septicemia
Endocrine
Hypothyroidism
Inflammatory myopathies
Moderate CK elevations only<unk>  only described in case reports)
Miscellaneous
Status Asthmaticus
Toxic shock syndrome
Mushroom ingestion
Crush Syndrome
Immobilization
Compartment Syndrome
Exercise + hot weather
Exercise + sickle cell
Exercise + Hypokalemia
Hyperkinetic states
Seizure
DTs
Stimulant / Sympathomimetic overdose
Malignant Hyperthermia
Neuroleptic malignant syndrome
Seizure
DTs
Stimulant / Sympathomimetic overdose
Malignant Hyperthermia
Neuroleptic malignant syndrome
Drugs and toxins
Coma induced by sedatives
Alcohol
Coma-induced muscle compression
Direct toxic effect
Nutritional compromise increases risk (hypoK, hypoMg, hypoPhos)
Statins
Colchicine
CO Poisoning
Infection
Viral myositis - influenza, coxsackie, EBV, HSV, HIV, CMV
Bacterial pyomyositis
Septicemia
Endocrine
Hypothyroidism
Inflammatory myopathies
Moderate CK elevations only<unk>  only described in case reports)
Miscellaneous
Status Asthmaticus
Toxic shock syndrome
Mushroom ingestion
Coma induced by sedatives
Alcohol
Coma-induced muscle compression
Direct toxic effect
Nutritional compromise increases risk (hypoK, hypoMg, hypoPhos)
Statins
Colchicine
CO Poisoning
Coma-induced muscle compression
Direct toxic effect
Nutritional compromise increases risk (hypoK, hypoMg, hypoPhos)
Viral myositis - influenza, coxsackie, EBV, HSV, HIV, CMV
Bacterial pyomyositis
Septicemia
Hypothyroidism
Moderate CK elevations only<unk>  only described in case reports)
Status Asthmaticus
Toxic shock syndrome
Mushroom ingestion
Rhabdomyolysis
Compartment syndrome
Diabetic ketoacidosis 
Contusion
Diabetic ketoacidosis
Crush syndrome
Tumor lysis syndrome
Degloving injury