Abbreviation: G6PD
X-Linked recessive; protects against Malaria
Mild form exists, which predominantly affects men of African decent. It is typically self-limited because it affects older RBCs (with less G6PD left)
More severe form occurs predominantly in men of Mediterranean descent (specifically Greeks and Italians). Causes a more severe hemolytic anemia because RBCs of any age are involved
Nonimmune mediated hemolytic anemia
Stress or drugs can cause hemoglobin precipitation within the RBC
Leads to removal of the cell from circulation via the spleen
Leads to removal of the cell from circulation via the spleen
Infection
Fava beans
Medications
Nitrofurantoin
Phenazopyridine
Dapsone
Chloramphenicol
Antimalarials (e.g. quinine, mefloquine)
Sulfonamides
Ciprofloxacin, norfloxacin
Methylene blue
Vitamin K analogues (e.g. warfarin)
Nitrofurantoin
Phenazopyridine
Dapsone
Chloramphenicol
Antimalarials (e.g. quinine, mefloquine)
Sulfonamides
Ciprofloxacin, norfloxacin
Methylene blue
Vitamin K analogues (e.g. warfarin)
Glucose-6-phosphate deficiency
Hemorrhage
Vitamin B9 deficiency
Hereditary
Gamma hydroxybutyrate toxicity
Acquired
Thalassemia
Microangiopathic Hemolytic Anemia 