Allergy to class/drug
Obstructive jaundice
Diarrhea due to pseudomembranous enterocolitis or infectious enterotoxin-producing bacteria (e.g. c. diff)
Tablets only: children age <6y (risk of respiratory/CNS depression)
Concomitant MAOI therapy
Diphenoxylate/atropine
Dicyclomine
Atropine
Doxylamine
Dimenhydrinate
Cefpodoxime
Homatropine
Physostigmine