Varies depending on disorder
Lethargy, AMS, encephalopathy (often hyperammonemic)
Seizure
Hypotonia
Nausea/vomiting, diarrhea
Difficulty feeding
Failure to thrive
Unusual odors
Hypoglycemia
Organomegaly
+/- Skin rashes
+/- Eye findings
Signs/symptoms of dehydration
Infections
Inborn errors of metabolism
THE MISFITS [1]
Thalassemia
Trauma
Retinoic acid syndrome
Heart
Neonatal jaundice
Congenital heart disease