Parasympathetic - ACh is transm
Muscarinic
receptors in heart, eye, lung, GI, skin and sweat glands
Bradycardia
Miosis
Bronchorrhea / Bronchospasm
Hyperperistalsis (SLUDGE)
Sweating
Vasodilation
Nicotinic
receptors in both sympathetic and parasympathetic nervous systems
fasciculations, flaccid paralysis
?Mild bradycardia, hypotension
Sympathetic
Alpha effects (vessels, eye, skin)
Mydriasis, hypertension, sweating
Beta effects (heart, lungs)
Tachycardia, bronchodilation
Symptoms caused by acetylcholine buildup in CNS and PNS.
CNS symptoms = headache, confusion, vertigo, seizures, coma
Muscarinic Receptors
SLUDGE(M) = Salivation, Lacrimation, Urination, Diarrhea, GI pain, Emesis, Miosis
Nicotinic Receptors (NMJ)
MTWThF = Mydriasis/Muscle cramps, Tachycardia, Weakness, Twitching, Hypertension/Hyperglycemia, Fasiculations
Common causes of death in organophosphate toxicity
Killers B's = Bradycardia, Bronchorrhea, Bronchospasm
Muscarinic
receptors in heart, eye, lung, GI, skin and sweat glands
Bradycardia
Miosis
Bronchorrhea / Bronchospasm
Hyperperistalsis (SLUDGE)
Sweating
Vasodilation
Nicotinic
receptors in both sympathetic and parasympathetic nervous systems
fasciculations, flaccid paralysis
?Mild bradycardia, hypotension
receptors in heart, eye, lung, GI, skin and sweat glands
Bradycardia
Miosis
Bronchorrhea / Bronchospasm
Hyperperistalsis (SLUDGE)
Sweating
Vasodilation
receptors in both sympathetic and parasympathetic nervous systems
fasciculations, flaccid paralysis
?Mild bradycardia, hypotension
Alpha effects (vessels, eye, skin)
Mydriasis, hypertension, sweating
Beta effects (heart, lungs)
Tachycardia, bronchodilation
Mydriasis, hypertension, sweating
Tachycardia, bronchodilation
SLUDGE(M) = Salivation, Lacrimation, Urination, Diarrhea, GI pain, Emesis, Miosis
MTWThF = Mydriasis/Muscle cramps, Tachycardia, Weakness, Twitching, Hypertension/Hyperglycemia, Fasiculations
Killers B's = Bradycardia, Bronchorrhea, Bronchospasm
Carbamate toxicity
Tianeptine toxicity
Mushroom toxicity, especially:
Chlorate toxicity
Amanita muscaria
Lysergic acid diethylamide toxicity
Inocybe
Phencyclidine toxicity