Suspect in patient with known cancer (esp lung, breast, prostate) + back pain
Occurs in thoracic location in 70% of patients
Malignant spinal cord compression
Malignant airway obstruction
Spinal cord compression 
Bone metastases and pathologic fractures
Epidural compression syndromes
Spinal stenosis
Malignant Pericardial Effusion and Tamponade
Vertebral osteomyelitis