Coverage should extend to E. coli, Klebsiella, Proteus, and Bacteroides (an anaerobe)<unk> prophylaxis should be coordinated with surgical consult
Options:
Cefoxitin 2g IV q6 hours OR
Cefotetan 2g IV q12 hours OR
Moxifloxacin 400mg IV once daily OR
Ertapenem 1g IV once daily
Options:
Cefoxitin 40mg/kg IV q6 hours
Cefotetan 40mg/kg IV q12 hours
Gentamicin 2.5mg/kg IV q8hrs +
Metronidazole 7.5mg/kg IV 16hrs OR
Clindamycin 10mg/kg IV q8hrs
Metronidazole 7.5mg/kg IV 16hrs OR
Clindamycin 10mg/kg IV q8hrs
Defined as perforation, abscess, or phlegmon
Options:
Metronidazole 500 mg IV q8hrs +
Cefepime 50 mg/kg IV q12hrs OR
Ciprofloxacin 400 mg IV q12hrs OR
Levofloxacin 750 mg IV q24hrs OR
Aztreonam 30 mg/kg IV q8hrs
Imipenem/Cilastatin 25 mg/kg IV q6hrs (max 500mg)
Meropenem 20 mg/kg IV q8hrs (max 1g)
Piperacillin/Tazobactam 100 mg/kg (max 4.5g) IV q8hrs
Cefepime 50 mg/kg IV q12hrs OR
Ciprofloxacin 400 mg IV q12hrs OR
Levofloxacin 750 mg IV q24hrs OR
Aztreonam 30 mg/kg IV q8hrs
Cautious use should be applied to use of fluoroquinolones in complicated pediatric appendicitis due to the risk of tendon injury
GI antibiotics
Sepsis antibiotics
GU antibiotics
Antiemetics
Proton-pump inhibitor
Analgesics and sedatives 
OB/GYN antibiotics
Biliary ultrasound