Example protocol from Oscillate trial
Set FiO2 at 100%
Recruitment maneuver of 40 cmH2O PEEP for 40 seconds
I:E time of 1:2
Initiate<unk><unk><unk>  → 3-15 Hz
VT minimized to keep pH >7.25
Goal of 1-4 ml/Kg
Maintain mean airway pressure of 30 cmH2O with pressure adjusted to maintain a PaO2 of 55-80 mmHg
Reversion to standard<unk>  of mean airway pressure was ≤24 cmH2O for 12 hours or anytime when ≤20 cmH2O
Re-initiation of HFOV if FIO2 >0.4 or PEEP >14 cmH2O for >1 hour in the subsequent 48 hours
Goal of 1-4 ml/Kg
Targets
pH>7.25
SpO2 >88% or PaO2 >55mmHg
Oxygenation altered by:
FiO2
Mean airway pressures<unk>  altered by:<unk> 
Decrease<unk>  to increase TV and<unk> 
Inspiratory time
Amplitude of<unk> s
Decrease<unk>  to increase TV and<unk>
High frequency oscillation ventilation
Mechanical ventilation 
Airway pressure release ventilation
Pediatric jet ventilation
Bag valve mask ventilation
Lung recruitment maneuver
Advanced airway adjuncts
Oxygen therapy