Clinical course tends to be a dose-dependant progression from CNS symptoms to CVS symptoms and death
CNS symptoms
Agitation
Auditory changes/Tinnitus
Metallic taste
Seizures or drowsiness
Coma
Respiratory arrest
Cardiovascular
Early signs
Tachycardia
Ventricular dysrhythmia
Hypertension
Late signs
Bradycardia
Conduction block
Cardiovascular collapse
Asystole
Agitation
Auditory changes/Tinnitus
Metallic taste
Seizures or drowsiness
Coma
Respiratory arrest
Early signs
Tachycardia
Ventricular dysrhythmia
Hypertension
Late signs
Bradycardia
Conduction block
Cardiovascular collapse
Asystole
Tachycardia
Ventricular dysrhythmia
Hypertension
Bradycardia
Conduction block
Cardiovascular collapse
Asystole
Local anesthetic systemic toxicity
Anaphylaxis
Nitrogen narcosis
Anxiety
Calcium channel blocker toxicity
Methemoglobinemia - local anesthestics oxidize Fe2+ to Fe3+ in Hb
Cholinergic crisis
Phenothiazines