Half-life: 1.5 hrs
Metabolism: Hepatic
Excretion: Urine
Mechanism of Action:
Binds to and activates antithrombin which in turns inactivates factor Xa and thrombin
Anticoagulation effect lasts up to 3hr after stopping infusion
Must give IV (not subq) for acute thromboembolic disease
Unpredictable anticoagulation effect
Must monitor with PTT; therapeutic range is 1.5-2.5x normal value
Binds to and activates antithrombin which in turns inactivates factor Xa and thrombin
Unpredictable anticoagulation effect
Must monitor with PTT; therapeutic range is 1.5-2.5x normal value
Unfractionated heparin
Enoxaparin
Argatroban
Ticlopidine
Apixaban
Bivalirudin
Dalteparin
Low molecular weight heparin