Treatment is generally initiated after coordination with occupational health and infectious disease service and based the the exposed patient's vaccination history
If the source is HBsAg(+) then give HBIG x1 and initiate HBV vaccine in two separate sites
If source is HGsAG(-) then start the HBV vaccine series
If source blood is unavailable and high risk then give HBIG x1 initiate the HBV series
If source blood is low risk and unavailable then begin HBV series
If source blood is low risk and unavailable then begin HBV series
Non responder status is defined as anti-has <10mIU/mL
If the source is HBsAg(+) then give HBIG x 1 and begin revaccination series
Can also opt to perform second HBIG administration in one month
If source is HBsAg(-) then no treatment is needed
If source blood is unavailable and high risk then treat as if HBsAg(+)
Can also opt to perform second HBIG administration in one month
Non responder status is defined as anti-has <10mIU/mL
If the source is HBsAg(+) then give HBIG x2 and no HBV series
If source is HGsAG(-) then no treatment is needed
If source blood is unavailable then initiate the HBV series
No contraindications for pregnancy or breast feeding
HBIG 0.06 mL/kg IM
Give in opposite arm from hepatitis B vaccine if patient also receiving vaccine
Vaccination series: HBV vaccine options:
Engerix-B 20mcg IM
Recombivax HB 10mcg IM
Give in opposite arm from hepatitis B vaccine if patient also receiving vaccine
Engerix-B 20mcg IM
Recombivax HB 10mcg IM
Post exposure prophylaxis antibiotics
Pediatric antibiotics
Isolation precautions
Environmental exposure antibiotics
Tetanus prophylaxis
Newborn resuscitation
Neonatal resuscitation
Vaccination schedule