Systemic inflammatory response syndrome that can be adverse effect of certain immunotherapies, such as monoclonal antibodies and CAR-T therapies (e.g. CART19 for leukemia)
Pathophysiology and presentation similar to sepsis
Severity ranges from mild flu-like illness to severe sepsis-like inflammatory response with shock, vascular leakage, DIC, and multi-organ system failure
Cytokine release syndrome
Sepsis!
Immune reconstitution inflammatory syndrome
Hemophagocytic lymphohistiocytosis
Immune reconstitution syndrome
Cardiogenic
Pancoast syndrome
Acute valvular Regurgitation/VSD