<unk>  determined by mg/kg of elemental<unk>  ingested
^Total amount of elemental<unk>  ingested calculated by multiplying estimated number of tablets by the percentages of<unk>  in the tablet preparation (see above)
Direct caustic injury to gastric mucosa
Occurs early, usually within several hours
Causing vomiting, diarrhea, abdominal pain, and GI bleeding
Usually affects, the stomach, duodenum, colon rarely affected
Can lead to formation of gastric strictures 2-8 weeks post-ingestion
Impaired cellular metabolism
Inhibiting the electron transport chain causes lactic acidosis
Direct hepatic, CNS, and cardiac<unk>  (decreased CO and myocardial contractility)
Cell membrane injury from lipid peroxidation
Increased capillary permeability
Hypotension
Venodilation
Hypovolemic shock
Portal vein<unk>  delivery to liver
Overwhelm storage capacity of Ferritin
Hepatotoxicity (cloudy swelling, periportal hepatic necrosis, elevated transaminases)
Destroys hepatic mitochondria, disrupts oxidative phosphorylation → worsening metabolic acidosis
Thrombin formation inhibition
Coagulopathy - direct effect on vitamin K clotting factors
Causing vomiting, diarrhea, abdominal pain, and GI bleeding
Usually affects, the stomach, duodenum, colon rarely affected
Can lead to formation of gastric strictures 2-8 weeks post-ingestion
Inhibiting the electron transport chain causes lactic acidosis
Direct hepatic, CNS, and cardiac<unk>  (decreased CO and myocardial contractility)
Cell membrane injury from lipid peroxidation
Hypotension
Venodilation
Hypovolemic shock
Overwhelm storage capacity of Ferritin
Hepatotoxicity (cloudy swelling, periportal hepatic necrosis, elevated transaminases)
Destroys hepatic mitochondria, disrupts oxidative phosphorylation → worsening metabolic acidosis
Coagulopathy - direct effect on vitamin K clotting factors
Iron toxicity
Aluminum toxicity
Zinc toxicity
Antimony toxicity
Gold toxicity
Arsenic toxicity
Nickel toxicity
Barium toxicity