Appearance on plain radiographs often described as “onion peel” or “moth-eaten” appearance referring to the respective periosteal bone formation and osseous destruction
LDH is a prognostic factor
Definitive diagnosis is made with biopsy
Work-up often includes PET scan for metastatic disease
t(11;22) translocation is often seen
Ewing sarcoma
Multiple myeloma
Osteosarcoma
Chondrosarcoma
Paget disease
Myositis ossificans
Kaposi's sarcoma
Adamantinoma