Nicotine is also an irritant and eye pain is a frequent complaint
Due to the neuromuscular nicotinic activation
At high doses nicotine will activate muscarinic receptors
Initially present with excitation, N/V/D, salivation, tachycardia, hypertension, diaphoresis
Delayed presentation is hypotension, bradycardia, hypoventilation, fasiculations, seizures, coma, and death
Electronic cigarettes
Anticholinergic Toxicity
Dirty bomb
Organophosphate Toxicity
Hazmat exposure
Sympathomimetic Toxicity
Caustic cocktail
Neuroleptic Malignant Syndrome 