Neonatal HSV
40-60mg/kg/day IV divided q12h x 14-21 d
HSV encephalitis
3 mo - 11 y/o
30-45mg/kg/day IV divided q8h x 14-21 d
>12 y/o
30mg/kg/day IV divided q8h x 14-21 d
Genital/mucocutaneous HSV
Immunocompetent
1st episode, 2-11 y/o
40-80mg/kg/day PO divided q6-8 h x 5 d, max 1g/day
1st episode, >12 y/o
1g/day PO divided 5x/day x 7-10 d
Immunocompromised
PO: >2 y/o: 1g/day PO divided 3-5x/day x 7-14 d
IV: >1 y/o: 30mg/kg/day IV divided q8h x 7-14 d
Varicella
Immunocompetent
PO: > 2 y/o: 80mg/kg/day PO divided q6h x 5 d
IV: > 1 y/o: 30mg/kg/day IV divided q8h x 7-10 d
Immunocompromised
30mg/kg/day IV divided q8h x 7-10 d
Herpes zoster
Immunocompetent
PO: > 12 y/o: 4g/day PO divided 5x/day x 5-7 d
IV: 30mg/kg/day IV divided q8h x 7-10 d
Immunocompromised
30mg/kg/day IV divided q8h x 7-10 d
40-60mg/kg/day IV divided q12h x 14-21 d
3 mo - 11 y/o
30-45mg/kg/day IV divided q8h x 14-21 d
>12 y/o
30mg/kg/day IV divided q8h x 14-21 d
30-45mg/kg/day IV divided q8h x 14-21 d
30mg/kg/day IV divided q8h x 14-21 d
Immunocompetent
1st episode, 2-11 y/o
40-80mg/kg/day PO divided q6-8 h x 5 d, max 1g/day
1st episode, >12 y/o
1g/day PO divided 5x/day x 7-10 d
Immunocompromised
PO: >2 y/o: 1g/day PO divided 3-5x/day x 7-14 d
IV: >1 y/o: 30mg/kg/day IV divided q8h x 7-14 d
1st episode, 2-11 y/o
40-80mg/kg/day PO divided q6-8 h x 5 d, max 1g/day
1st episode, >12 y/o
1g/day PO divided 5x/day x 7-10 d
40-80mg/kg/day PO divided q6-8 h x 5 d, max 1g/day
1g/day PO divided 5x/day x 7-10 d
PO: >2 y/o: 1g/day PO divided 3-5x/day x 7-14 d
IV: >1 y/o: 30mg/kg/day IV divided q8h x 7-14 d
Immunocompetent
PO: > 2 y/o: 80mg/kg/day PO divided q6h x 5 d
IV: > 1 y/o: 30mg/kg/day IV divided q8h x 7-10 d
Immunocompromised
30mg/kg/day IV divided q8h x 7-10 d
PO: > 2 y/o: 80mg/kg/day PO divided q6h x 5 d
IV: > 1 y/o: 30mg/kg/day IV divided q8h x 7-10 d
30mg/kg/day IV divided q8h x 7-10 d
Immunocompetent
PO: > 12 y/o: 4g/day PO divided 5x/day x 5-7 d
IV: 30mg/kg/day IV divided q8h x 7-10 d
Immunocompromised
30mg/kg/day IV divided q8h x 7-10 d
PO: > 12 y/o: 4g/day PO divided 5x/day x 5-7 d
IV: 30mg/kg/day IV divided q8h x 7-10 d
30mg/kg/day IV divided q8h x 7-10 d
Acyclovir
Valacyclovir
Valganciclovir
Famciclovir
Ganciclovir
Topical steroids
Intravenous immunoglobulin
Magic mouthwash