2-15 yo
20-30 mg/kg PO QD
Start: 20 mg/kg PO QD
Max: 40 mg/kg/day
Adjust dose by 5-10 mg/kg/day q3-6mo based on serum ferritin
Decrease dose 10 mg/kg/day if Cr >33% above baseline and >ULN
16+ yo
20-30 mg/kg PO QD
Start: 20 mg/kg PO QD
Max: 40 mg/kg/day
Adjust dose by 5-10 mg/kg/day q3-6mo based on serum ferritin
Decrease dose 10 mg/kg/day if Cr >33% above baseline x2 weeks
20-30 mg/kg PO QD
Start: 20 mg/kg PO QD
Max: 40 mg/kg/day
Adjust dose by 5-10 mg/kg/day q3-6mo based on serum ferritin
Decrease dose 10 mg/kg/day if Cr >33% above baseline and >ULN
Start: 20 mg/kg PO QD
Max: 40 mg/kg/day
Adjust dose by 5-10 mg/kg/day q3-6mo based on serum ferritin
Decrease dose 10 mg/kg/day if Cr >33% above baseline and >ULN
20-30 mg/kg PO QD
Start: 20 mg/kg PO QD
Max: 40 mg/kg/day
Adjust dose by 5-10 mg/kg/day q3-6mo based on serum ferritin
Decrease dose 10 mg/kg/day if Cr >33% above baseline x2 weeks
Start: 20 mg/kg PO QD
Max: 40 mg/kg/day
Adjust dose by 5-10 mg/kg/day q3-6mo based on serum ferritin
Decrease dose 10 mg/kg/day if Cr >33% above baseline x2 weeks
10-15 yo
10-20 mg/kg PO QD
Start: 10 mg/kg PO QD
Max: 20 mg/kg/day
Adjust dose based on serum ferritin trends and liver iron concentration
Decrease dose 5 mg/kg/day if Cr >33% above baseline and >ULN
16+ yo
10-20 mg/kg PO QD
Start: 10 mg/kg PO QD
Max: 20 mg/kg/day
Adjust dose based on serum ferritin trends and liver iron concentration
Decrease dose 50% if Cr >33% above baseline x2 weeks
Interrupt treatment if already at 5 mg/kg/day
10-20 mg/kg PO QD
Start: 10 mg/kg PO QD
Max: 20 mg/kg/day
Adjust dose based on serum ferritin trends and liver iron concentration
Decrease dose 5 mg/kg/day if Cr >33% above baseline and >ULN
Start: 10 mg/kg PO QD
Max: 20 mg/kg/day
Adjust dose based on serum ferritin trends and liver iron concentration
Decrease dose 5 mg/kg/day if Cr >33% above baseline and >ULN
10-20 mg/kg PO QD
Start: 10 mg/kg PO QD
Max: 20 mg/kg/day
Adjust dose based on serum ferritin trends and liver iron concentration
Decrease dose 50% if Cr >33% above baseline x2 weeks
Interrupt treatment if already at 5 mg/kg/day
Start: 10 mg/kg PO QD
Max: 20 mg/kg/day
Adjust dose based on serum ferritin trends and liver iron concentration
Decrease dose 50% if Cr >33% above baseline x2 weeks
Interrupt treatment if already at 5 mg/kg/day
Interrupt treatment if already at 5 mg/kg/day
Deferasirox
Succimer
Deferoxamine
Colestipol
Ulipristal
EDTA
Dimercaprol
Senna