Also referred to as HIV encephalopathy
Progressive disorder heralded by impairment of recent memory and other cognitive deficits
Occurs in 10-15% of HIV+ patients; 30% of patients with CD4 <100
Diagnosis of exclusion
AIDS dementia complex
Hypoxic encephalopathy
Anti-NMDA receptor encephalitis
Acute toxic-metabolic encephalopathy 
Prion disease
Hypoglycemia
HIV neurologic complications
Hyperosmolar state 