Inhibits Na+/K+ ATPase in the myocardium
Causes increase in intracellular sodium levels
Results in reversal of sodium-calcium exchanger
Normally imports three extracellular sodium ions into the cardiac myocyte in exchange for one intracellular calcium being exported
Sodium accumulates intracellularly and is exchanged for Calcium.
Causes an increase in the intracellular calcium concentration increasing contractility
Also a lengthening of phase 4 and phase 0 of the cardiac action potential which ultimately decreases heart rate
Summary
Inhibits NaK pump
Positive inotropy
Negative chronotropy/dromotropy
Indirect vagal stimulator
Causes increase in intracellular sodium levels
Results in reversal of sodium-calcium exchanger
Normally imports three extracellular sodium ions into the cardiac myocyte in exchange for one intracellular calcium being exported
Sodium accumulates intracellularly and is exchanged for Calcium.
Causes an increase in the intracellular calcium concentration increasing contractility
Also a lengthening of phase 4 and phase 0 of the cardiac action potential which ultimately decreases heart rate
Normally imports three extracellular sodium ions into the cardiac myocyte in exchange for one intracellular calcium being exported
Also a lengthening of phase 4 and phase 0 of the cardiac action potential which ultimately decreases heart rate
Inhibits NaK pump
Positive inotropy
Negative chronotropy/dromotropy
Indirect vagal stimulator
Positive inotropy
Indirect vagal stimulator
Digoxin
Amiodarone
Metoprolol
Carvedilol
Sotalol
Captopril
Ibutilide
Esmolol