Initiate as soon as possible; increased infection rate when delayed
Cefazolin (Ancef) 2 g IV (immediately and q8 hours x 3 total doses)
Cephalosporin allergy: clindamycin 900 mg IV (immediately and q8 hours x 3 total doses)
Ceftriaxone 2 g IV (immediately x 1 total dose) PLUS vancomycin 1 g IV (immediately and q12 hours x 2 total doses)
Cephalosporin allergy: aztreonam 2 g IV (immediately and q8 hours x 3) PLUS vancomycin 1 g IV (immediately and q12 hours x 2 total doses)
Concern for clostridium (soil contamination, farm injuries, possible bowel contamination): additionally add penicillin
Fresh water wounds: fluoroquinolones OR 3rd/4th generation cephalosporin
Saltwater wounds (vibrio): doxycycline + ceftazidime OR fluoroquinolone
Bone and joint antibiotics
GU antibiotics
Skin and soft tissue antibiotics
Neuro antibiotics
Nonsteroidal anti-inflammatory drugs
Antibiotics 
Cardiovascular antibiotics
Beta-lactams