<unk> should be defined as life-threatening organ dysfunction caused by a dysregulated host response to infection
The infection is most commonly by bacteria, but can also be by fungi, viruses, or parasites
Risk of death from<unk> being as high as 30%, severe<unk> as high as 50%, and septic shock as high as 80% 
The most common primary sources of infection resulting in<unk> are the lungs, the abdomen, and the urinary tract<unk> carries a 40% in hospital mortality
Positive cultures are not obligatory in the diagnosis of<unk> Pneumonia, abdominal abscess and pyelonephritis are common primary causes of<unk> In 2016 new definitions were adopted for the evaluation and diagnosis of<unk>  Severe<unk> and Septic shock
Hypotension with SBP <100 or
altered mental status  or
Tachypnea (RR >/=22) OR
Increase in SOFA score by 2 points
SBP< 90 or
MAP <65 lactate >2 or
INR >1.5 or
Bili>2 or
Urine output <0.5ml/kg/h
Creatinine>2.2 or
Platelets <100 or
SpO@<90%
Quick Sequential<unk> Related) Organ Failure Assessment Score
Respiratory rate of 22/min or greater (+1 Point)
Altered mentation (+1 Point)
Systolic blood pressure of 100 mm Hg or less (+1 Point)
The SOFA is generally used in the ICU and can stratify the mortality of patients based on the initial score and subsequent changes in score
The Mortality in Emergency Department<unk> (MEDS) prediction rule is a proposed method to risk stratify ED patients with<unk> National Early Warning Score (NEWS) 2 determines degree of critically ill patient, in non-pregnant patients ≥16 years old
Used by the UK NHS to identify acutely ill patients, including those with<unk> Not reliable in spinal cord injury patients due to disturbance of autonomic responses
Combination of:
Respiratory rate
Presence of hypercapnic respiratory failure
Presence of supplemental O2
Temperature
SBP
Pulse rate
Consciouness
See below for MDCalc link
Respiratory rate
Presence of hypercapnic respiratory failure
Presence of supplemental O2
Temperature
SBP
Pulse rate
Consciouness
Still acceptable to use in ED depending on local protocol
Misses up to 1/8 very septic ICU patients

≥2 of 4 criteria must be present:
Sepsis 
Adrenal Insufficiency
Tumor lysis syndrome
Salicylate Toxicity
Hemorrhagic shock
Anticholinergic Toxicity
Toxic shock syndrome
Neuroleptic Malignant Syndrome