Usually progresses through 3 stages
Asymptomatic or indolent, nonspecific symptoms
Malaise, fatigue, weight loss, low grade fever
Lymphadenopathy, splenomegaly
Worsening of above symptoms due to progressive leukocytosis
Signs/symptoms of thrombocytopenia (e.g. petechiae, bleeding) or thrombocytosis
Behaves like acute leukemia
Associated with Leukostasis and hyperleukocytosis and Hyperviscosity syndrome
Chronic myeloid leukemia
Malignant airway obstruction
Acute myeloid leukemia
Bone metastases and pathologic fractures
Leukemoid Reaction
Malignant spinal cord compression
Chronic lymphocytic leukemia
Malignant Pericardial Effusion and Tamponade