History of HD, PD, renal transplant
Gadolinium exposure, with timeline of symptom onset variable
Develops days to years after gadolinium exposure
Chronic, progressive
Skin becomes tight, thick, shiny, and indurated skin, with fibrotic nodules and plaques and brawny hyperpigmentation
Painful, pruritic
Peau d'orange appearance
Extremities most commonly affected, followed by trunk. Face rarely involved
Flexion contractures when lesions overlie joints, limited range of motion
Hand stiffening
Extremities more commonly affected than trunk
Neuromuscular involvement can occur
In most severe cases,<unk>  involves internal organs (heart, lungs, liver)
Develops days to years after gadolinium exposure
Painful, pruritic
Peau d'orange appearance
Extremities most commonly affected, followed by trunk. Face rarely involved
Hand stiffening
Extremities more commonly affected than trunk
Nephrogenic systemic fibrosis
Scleroderma, morphea
Goodpasture syndrome
Calciphylaxis, which may coexist
Eosinophilic granulomatosis with polyangiitis
Cellulitis
Granulomatosis with polyangiitis
Necrotizing fasciitis