Acute phase (lasts up to 1 week)
Mild illness to abrupt high fever, chills, intense headache, and severe myalgias (75-100% of patients)
Conjunctival suffusion (redness without exudates) characteristic but not common
Meningitis, uveitis, transaminitis, hepatomegaly, proteinuria, hematuria
Weil syndrome - severe manifestation with jaundice and renal failure, aseptic meningitis, pulmonary hemorrhage, ARDS, myocarditis, and rhabdomyolysis (52% Mortality)
10% of patients
Caused by circulating antibodies
Mild illness to abrupt high fever, chills, intense headache, and severe myalgias (75-100% of patients)
10% of patients
Caused by circulating antibodies
Leptospirosis
Normal causes of acute fever!
Typhoid fever
Malaria
Drug fever
Dengue
Murine typhus
Chikungunya