Based on pretreatment INR, units based on factor 9 content
INR 2-4: 25units/kg, not to exceed 2500 units
INR 4-6: 35units/kg, not to exceed 3500 units
INR >6: 50units/kg, not to exceed 5000 units
Consider rechecking INR after 15 minutes to determine need for redosing
Fixed dose Kcentra equivalent to weight based (while being easier to administer and less expensive)
Baseline INR ≤7.5 and ≤100 kg: 1500 units of Kcentra
Baseline INR >7.5 or >100 kg: 2000 units of Kcentra
INR 2-4: 25units/kg, not to exceed 2500 units
INR 4-6: 35units/kg, not to exceed 3500 units
INR >6: 50units/kg, not to exceed 5000 units
Baseline INR ≤7.5 and ≤100 kg: 1500 units of Kcentra
Baseline INR >7.5 or >100 kg: 2000 units of Kcentra
Prothrombin complex concentrates
Vitamin K
Platelet transfusion
Cryoprecipitate transfusion
Protamine sulfate
Fresh frozen plasma
Unfractionated heparin reversal
Unfractionated heparin