Often an adolescent during a growth spurt
Bone pain for several months that worsens with activity and is more painful at night
Absence of constitutional symptoms (e.g., fevers, weight loss, night sweats, and decreased appetite are typically absent)
Large soft tissue mass on exam that is tender to palpation
Occurs at metaphysis of long bones
Most commonly at the distal femur followed by the proximal tibia
Less frequently presents as pathological fracture
Risk factors include prior cancer treatment, Paget disease of bone, benign bone disease, Hereditary Retinoblastoma or Li-Fraumeni syndrome
Most commonly at the distal femur followed by the proximal tibia
Osteosarcoma
Multiple myeloma
Ewing sarcoma
Chondrosarcoma
Paget disease
Myositis ossificans
Osteomyelitis
Adamantinoma