Note that initial presentation may stem from non-specific peripheral alpha1 agonism, and produce hypertension and reflex tachycardia - will transition to bradycardia and hypotension when central effects take over
Cardiac (alpha2)
Bradycardia
Hypotension
Neuro
CNS depression (most common)
Lethargy (may progress to apnea)
Miotic pupils
Respiratory depression
Respiratory
Hypoventilation
Hypoxia
Cheynes-Stokes respiration
Periodic apnea
Hypothermia
Can mimic opioid overdose
obtundation, miosis, respiratory depression, and hypothermia
Can mimic digoxin, Beta-blocker, or CCB toxicity with hypotension and bradycardia
Withdrawal from<unk>  presents with tachycardia, hypertension, tremors, and agitation
Bradycardia
Hypotension
CNS depression (most common)
Lethargy (may progress to apnea)
Miotic pupils
Respiratory depression
Hypoventilation
Hypoxia
Cheynes-Stokes respiration
Periodic apnea
obtundation, miosis, respiratory depression, and hypothermia
Clonidine toxicity
Cholinergic crisis
Tricyclic antidepressant toxicity
Yohimbine toxicity
Antipsychotic toxicity
Flunitrazepam toxicity
Beta-blocker toxicity
Caffeine withdrawal