Leading cause of pediatric mortality related to sickle cell disease
More common in pediatric patients as many adults with SCD have autoinfarcted their spleen
Earliest life threatening complication of SCD with median age 1-43
Red blood cells sickle, aggregate, and occlude<unk>  vasculature
Sequestering leads to splenomegaly
Defined as splenomegaly and a 2g/dL drop in hemoglobin
Some resources differentiate between major and minor episodes depending on the hgb drop
Lifelong prevalence 7-30%3
Often precipitated by underlying infection (pneumonia, gastroenteritis)
Defined as splenomegaly and a 2g/dL drop in hemoglobin
Some resources differentiate between major and minor episodes depending on the hgb drop
Some resources differentiate between major and minor episodes depending on the hgb drop
Splenic sequestration
Vaso-occlusive pain crisis
Platinum toxicity
Bony infarction
Levamisole toxicity
Dactylitis
Graft-vs-host disease
Avascular necrosis of femoral head