Autoimmune disease typically seen in young men
Progressive inflammation and fibrosis of intra/extra hepatic bile ducts
Most (80%) cases are associated with inflammatory bowel disease, typically ulcerative colitis, 10% of patients with ulcerative colitis have<unk> 
Increased risk of colon cancer in patients with Ulcerative colitis and<unk>  (more than UC alone) Increased risk of cholangiocarcinoma
Prevalence is 1 to 6 per 100,000 in the U.S
Primary sclerosing cholangitis
Amebiasis
Ischemic hepatitis
Autoimmune hepatitis
Choledocholithiasis
Viral hepatitis
Non-alcoholic steatohepatitis
Acute alcoholic hepatitis