Half-life:
Children: 1.7 hours
Adults with normal renal function: 2.5-4.7 hours
Metabolism: By acetylation in the liver to produce N-acetyl<unk>  (NAPA)
Excretion: Urinary excretion (25% as NAPA)
Kinetics: Onset of action 5 - 10 minutes
Children: 1.7 hours
Adults with normal renal function: 2.5-4.7 hours
Class Ia
Binds to fast sodium channels in inactive state inhibiting recovery after repolarization
Prolongs action potential and reduces speed of impulse conduction
Depresses myocardial conduction
May act as negative inotrope, causing hypotension through peripheral vasodilation
Binds to fast sodium channels in inactive state inhibiting recovery after repolarization
Prolongs action potential and reduces speed of impulse conduction
Depresses myocardial conduction
May act as negative inotrope, causing hypotension through peripheral vasodilation
Depresses myocardial conduction
Procainamide
Flecainide
Propafenone
Verapamil
Ibutilide
Lofexidine
Amiodarone
Lidocaine