Disease of the neuromuscular junction leading to primary presentation of weakness
Caused by auto-antibodies against the voltage-gated calcium channels at the NMJ
Predominantly a disease associated with older men with history of cigarette smoking and lung cancer
50% of patients have concurrent small-cell lung cancer<unk>  can precede detection of malignancy by several years
Paraneoplastic<unk>  in 60-70% of cases
50% of patients have concurrent small-cell lung cancer
Lambert-Eaton myasthenic syndrome
Neuromuscular weakness
Guillain-Barre syndrome
Upper motor neuron:
Polymyositis
CVA
Amyotrophic lateral sclerosis
Hemorrhagic stroke