Skin infection caused by Mycobacterium ulcerans
Named for<unk> ruli district in Uganda
Begins as a localized lesion and progresses to extensive ulceration
Most frequent in humid, rural, tropical regions with limited access to medical care
Mode of transmission is not fully understood,<unk> t linked to contaminated water 
Human to human transmission is rare
Caused by Mycobacterium ulcerans, a slow growing mycobacterium that can be cultured in vitro at 29-33C
Mycobacterium ulcerans is capable of producing mycolactone, a cytotoxin that induces necrosis and ulceration
Effect of mylactone includes cell structural deformation and apoptosis of several cell types, including immune cells
Buruli ulcer
Eumycetoma
Lichen planus
Pyoderma gangrenosum
Lichen sclerosus
Venous stasis ulcer
Condyloma acuminata
Diabetic skin ulceration