Treatment is primary with penicillin with dosing and type of penicillin determined by the stage of disease
Treat those exposed within the past 3 months.
This is classified as primary, secondary, and early latent<unk>  less than one year.
Treatment Options:
Penicillin G Benzathine 2.4 million units IM x 1
Repeat dose after 7 days for pregnant patients and HIV infection
Doxycycline 100mg oral twice daily for 14 days as alternative
Repeat dose after 7 days for pregnant patients and HIV infection
Late stage is greater than one year duration, presence of gummas, or cardiovascular disease
Treatment Options:
Penicillin G Benzathine 2.4 million units IM weekly x 3 weeks
Doxycycline 100mg oral twice daily for 4 weeks as alternative
There are 3 Major options with none showing greater efficacy than others:
Penicillin G 3-4 million units IV every 4 hours x 10-14 days
Penicillin G 24 million units continuous IV infusion x 10-14 days
Penicillin G Procaine2.4 million units IM daily + probenecid 500mg oral every 6 hours for 10-14 days.
Alternative:
Ceftriaxone 2gm  IV once daily for 10-14 days
Ceftriaxone 2gm  IV once daily for 10-14 days
Desensitization to the penicillin allergy is still the preferred method of treatment for patients with early and late stage disease (especially during pregnancy)
Penicillin, dosage depends on stage 
Reaction to treatment consisting of fever, chills, myalgias, headache, tachycardia, increased respiratory rate, leukocytosis, vasodilation with mild hypotension
Usually resolves within 12-24 hours<unk> mptom based treatment
Syphilis
Ulcerative STDs
Smallpox
Proctitis
Leprosy
Genital Herpes
Rubella
Chancroid