Ocular (xerophthalmia)
Itching, burning sensation
Gritty, foreign body sensation
Dacryoadenitis
Optic neuritis
Parotid enlargement
Present in 1/3 of patients
May be chronic or relapsing
May lead to suppurative parotitis
Xerostomia
Constant thirst
Dental caries
Dysphagia
Pancreatitis
Respiratory
Pleuritis
Interstitial lung disease
Obstructive lung disease
Pulmonary hypertension
Respiratory arrest due to severe hypokalemia
Small-vessel vasculitis
Neurologic
Neuropsychiatric dysfunction
Transverse myelitis
Cerebral venous thrombosis
Optic nerve injury
Renal
Interstitial nephritis
Renal tubular acidosis
Hyperchloremic metabolic acidosis with low bicarb and hypokalemia
Cardiac
Pericarditis
Arrhythmia due to infiltrative disease
Increased risk of DVT/PE
Gastrointestinal
Primary biliary cirrhosis
Celiac sprue
Itching, burning sensation
Gritty, foreign body sensation
Dacryoadenitis
Optic neuritis
Present in 1/3 of patients
May be chronic or relapsing
May lead to suppurative parotitis
Constant thirst
Dental caries
Pleuritis
Interstitial lung disease
Obstructive lung disease
Pulmonary hypertension
Respiratory arrest due to severe hypokalemia
Neuropsychiatric dysfunction
Transverse myelitis
Cerebral venous thrombosis
Optic nerve injury
Interstitial nephritis
Renal tubular acidosis
Hyperchloremic metabolic acidosis with low bicarb and hypokalemia
Pericarditis
Arrhythmia due to infiltrative disease
Primary biliary cirrhosis
Celiac sprue
Sjögren syndrome
Sicca complex due to other autoimmune diseases
Behçet's disease
Sarcoidosis
Sweet's syndrome
Rheumatoid arthritis
Scleroderma
SLE