Known as<unk> 
A severe adverse<unk>  reaction
Usually begins within 8 weeks of starting a new<unk> 
8-10% mortality
Previously known as Dilantin Hypersensitivity<unk>  or Anti-convulsant hypersensitivity<unk> 
However, many other medications, particularly antibiotics
A virus-drug interaction with HHV-6, HHV-7, EBV, and CMV may be a form of pathogenesis as well
Most common
Phenytoin
Phenobarbital
Carbamazepine
Allopurinol
Sulfa<unk> s
Others
NSAIDS
Anti-retrovirals
ACE inhibitors
Calcium-channel blockers
Atypical antipsychotics (ziprasidone, olanzapine, etc.)
Other antibiotics
Phenytoin
Phenobarbital
Carbamazepine
Allopurinol
Sulfa<unk> s
NSAIDS
Anti-retrovirals
ACE inhibitors
Calcium-channel blockers
Atypical antipsychotics (ziprasidone, olanzapine, etc.)
Other antibiotics
Drug rash with eosinophilia and systemic symptoms syndrome
Positive Nikolsky’s sign
Jarisch-Herxheimer reaction
Febrile
Staphylococcal scalded skin syndrome
Staphylococcal scalded skin syndrome 
Immune reconstitution inflammatory syndrome
Toxic epidermal necrolysis/SJS 