Rapidly absorbed and extensively distributed
Maximum therapeutic dose: 8-10 mg in 1 day
Nausea, vomiting, abdominal pain, bloody diarrhea
Bone marrow suppression, renal failure
Lactic Acidosis
Delirium, seizures, coma
Death within 8-36 hours caused by respiratory failure or arrhythmia
Aggressive supportive care<unk> -specific antibodies are not available in U.S.)
If survival, can see rebound leukocytosis and transient alopecia
Colchicine
Diclofenac
Ketoprofen
Allopurinol
Acetaminophen
Ibuprofen
Celecoxib
Prednisolone