Half-life: 20-60h (anticoagulant effect)
Of note, half-life highly variable based on rate of clotting factor catabolism
Metabolism: Liver
Excretion: Urine 92%, bile
Mechanism of Action:
Blocks activation of vitamin K dependent prothrombotic factors II, VII, IX, X
Blocks synthesis of vitamin K dependent antithrombotic proteins C and S
Albumin bound
Of note, half-life highly variable based on rate of clotting factor catabolism
Blocks activation of vitamin K dependent prothrombotic factors II, VII, IX, X
Blocks synthesis of vitamin K dependent antithrombotic proteins C and S
Warfarin
Clopidogrel
Ticlopidine
Apixaban
Enoxaparin
Ticagrelor
Rivaroxaban
Eptifibatide