For acute epididymitis likely caused by STI
Ceftriaxone 250 mg IM in a single dose PLUS
Doxycycline 100 mg orally twice a day for 10 days
Ceftriaxone 250 mg IM in a single dose PLUS
Doxycycline 100 mg orally twice a day for 10 days
For acute epididymitis most likely caused by STI and enteric organisms (MSM)
Ceftriaxone 250 mg IM in a single dose PLUS
Levofloxacin 500 mg orally once a day for 10 days OR
Ofloxacin 300 mg orally twice a day for 10 days
Ceftriaxone 250 mg IM in a single dose PLUS
Levofloxacin 500 mg orally once a day for 10 days OR
Ofloxacin 300 mg orally twice a day for 10 days
For acute epididymitis most likely caused by enteric organisms
Levofloxacin 500 mg orally once daily for 10 days OR
Ofloxacin 300 mg orally twice a day for 10 days
Levofloxacin 500 mg orally once daily for 10 days OR
Ofloxacin 300 mg orally twice a day for 10 days
Treat sexual partner if possible
GU antibiotics
Sepsis antibiotics
OB/GYN antibiotics
Antibiotics 
Bone and joint antibiotics
Neuro antibiotics
ENT antibiotics
Skin and soft tissue antibiotics