Abbreviation:<unk> 
Similar to TTP (which is more common in adults), but associated with less central nervous system and more renal involvement.
Most cases occur in children <10yr (⅔ of cases in < 5yr)
80-90% cases due to E. coli O157:H7 infection
Shiga toxin may induce autoantibody to CD36 (found on endothelial cells and platelets)
May also be caused by shigella, yersinia, campylobacter, salmonella
Occurs 2-14d after development of infectious diarrhea (bloody, no fever)
Occurs in older children and adults
Extrarenal involvement is common (difficult to distinguish from TTP)
May be caused by atypical pathogens (EBV, S. pneumo) or immunosuppression
Hemolytic uremic syndrome
Gastroenteritis
Sickle cell crisis
Appendicitis
Hepatorenal syndrome
Colitis
Uremic bleeding syndrome
Intussusception