Initial features
Localized inflammatory reaction after tsetse fly bite
Painless chancre 2-3 days later, lasts 2-3 weeks
Systemic disease
Intermittent Fever
Malaise, wasting
CNS involvement
Behavioral changes
Encephalitis
Coma
Death
Other complications
Hemolysis, anemia
Pancarditis
Meningoencephalitis
Winterbottom's sign: posterior cervical LAD (Gambiense)
Localized inflammatory reaction after tsetse fly bite
Painless chancre 2-3 days later, lasts 2-3 weeks
Intermittent Fever
Malaise, wasting
Behavioral changes
Encephalitis
Coma
Death
Hemolysis, anemia
Pancarditis
Meningoencephalitis
African trypanosomiasis
Papules
Leishmaniasis
Insect bites
Babesiosis
Scabies
Malaria
Seabather's eruption