Cutaneous lesion + adult onset hypertension
Men > women (2:1)
Peak age 40-60s
Systemic: Fatigue, weight loss, weakness, fever, arthralgia
Cutaneous lesions (1/3 patients)
Tender erythematous nodules
Palpable purpura (fingers, ankles, malleoli, pretibial)
Digital cyanosis
Splinter hemorrhages
Livedo reticularis
Renovascular arteritis → hypertension
Peripheral neuropathies (mononeuritis multiplex, polyneuropathy)
Mesenteric vasculitis (abdominal angina, ischemia, infarction, perforation)
Myocardial ischemia and heart failure
Myalgia (elevated CK)
Tender erythematous nodules
Palpable purpura (fingers, ankles, malleoli, pretibial)
Digital cyanosis
Splinter hemorrhages
Livedo reticularis
Polyarteritis nodosa
Embolism, thrombosis, atherosclerosis
Thromboangiitis obliterans
HIV, Hepatitis, IE, mycotic aneurysm
Takayasu arteritis
Fibromuscular dysplasia
Granulomatosis with polyangiitis
Microscopic polyangiitis, Granulomatosis with polyangiitis 