Pregnancy Rating: B (animal studies show no risk for adverse fetal effects, human fetal harm possible but unlikely)
Lactation: Probably Safe
Renal Dosing
Adult: CrCL 10-50: decrease dose 50%, CrCl <10, decrease dose 75%
Pediatric: CrCl 20-40, decrease dose 25% or give q8h, CrCL <20: decrease dose 50%
Hepatic Dosing
Adult: Not Defined
Pediatric not defined
Adult: CrCL 10-50: decrease dose 50%, CrCl <10, decrease dose 75%
Pediatric: CrCl 20-40, decrease dose 25% or give q8h, CrCL <20: decrease dose 50%
Adult: Not Defined
Pediatric not defined
Cimetidine
Ranitidine
Sucralfate
Lansoprazole
Pantoprazole
Omeprazole
Bismuth subsalicylate
Loperamide