Pregnancy: C (risk cannot be ruled out)
Lactation: safety unknown
Renal Dosing
Adult
all uses with out ritonavir or atazanavir
GFR < 30: decrease dose 50% or give IR form q24h or ER form q48h
HD/PD: no supplement
concomitant ritonavir or atazanavir
GFR 30-60: decrease dose 50%
GFR < 30: decrease dose 75%
HD/PD: no supplement
Pediatric
all uses without ritonavir or atazanavir
GFR < 30: decrease dose 50% or give q24h
HD/PD: no supplement
concomitant ritonavir or atazanavir
not defined
Hepatic Dosing
Adult: no adjustment
Pediatric: no adjustment
Adult
all uses with out ritonavir or atazanavir
GFR < 30: decrease dose 50% or give IR form q24h or ER form q48h
HD/PD: no supplement
concomitant ritonavir or atazanavir
GFR 30-60: decrease dose 50%
GFR < 30: decrease dose 75%
HD/PD: no supplement
Pediatric
all uses without ritonavir or atazanavir
GFR < 30: decrease dose 50% or give q24h
HD/PD: no supplement
concomitant ritonavir or atazanavir
not defined
all uses with out ritonavir or atazanavir
GFR < 30: decrease dose 50% or give IR form q24h or ER form q48h
HD/PD: no supplement
concomitant ritonavir or atazanavir
GFR 30-60: decrease dose 50%
GFR < 30: decrease dose 75%
HD/PD: no supplement
GFR < 30: decrease dose 50% or give IR form q24h or ER form q48h
HD/PD: no supplement
GFR 30-60: decrease dose 50%
GFR < 30: decrease dose 75%
HD/PD: no supplement
all uses without ritonavir or atazanavir
GFR < 30: decrease dose 50% or give q24h
HD/PD: no supplement
concomitant ritonavir or atazanavir
not defined
GFR < 30: decrease dose 50% or give q24h
HD/PD: no supplement
not defined
Adult: no adjustment
Pediatric: no adjustment
Clarithromycin
Erythromycin
Paromomycin
Clindamycin
Meropenem
Kanamycin
Aztreonam
Ampicillin