Decline in mental status (GCS <14) in any hour within 1st 24 hours
3.5% developed GCS <14, no difference among groups
3.5% developed GCS <14, no difference among groups<unk> ly apparent brain injury (initiation of hyperosmolar therapy, intubation, death), short term memory, and memory and IQ 2-6 months after recovery
1.6% required hyperosmolar therapy, no difference among groups
0.9% (12 patients) had<unk> ly apparent brain injury, one death with remaining recovering without overt neurologic deficit, no difference among groups
0.9% (12 patients) had<unk> ly apparent brain injury, one death with remaining recovering without overt neurologic deficit, no difference among groups
Neurocognitive assessment
30% of patients lost to follow-up or declined to return
no difference in treatment groups with >60% that did follow-up
8 different subgroups
Relative risk of decline in GCS didn’t differ among subgroups
Forward digit span scores improved quicker in rapid rehydration subgroup with lowest PCO2
Backward digit span scores improved quicker in rapid rehydration subgroup with lowest pH
Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis
Austere peritoneal dialysis
High dose insulin therapy
Hemodialysis/Hemoperfusion
Iridodialysis
Transjugular intrahepatic portosystemic shunt
Reduced-osmolarity oral rehydration solution
Theraputic peritoneal lavage