See above guidelines for when to dose NAC
Less preferred than IV route due to unpleasant taste and smell
140 mg/kg PO load
70 mg/kg PO q4hr x17 doses additional; dilute to 5% soln
Loading dose: 150mg/kg in 100 mL D5W over 60min
Second (maintenance) dose: 50mg/kg in 250 mL D5W over 4hr
Third dose: 100mg/kg in 500 mL D5W over 16hr
Almost 100% effective if given <8 hr post-ingestion; less effective if 16-24 hr post-ingestion
May still be useful >24 hr post-ingestion, even with fulminant hepatic failure. Give NAC until LFTs improve (not until APAP level is 0)  
Be aware NAC treatment may affect PT. May see a dose-dependent increase in PT following NAC in patients without hepatotoxicity.
Acetaminophen toxicity
Acetaminophen toxicity 
Mescaline toxicity
Viral hepatitis
Cocaine toxicity
Hepatitis A
Carbamate toxicity
Hepatitis B