Also known as Leptomeningeal Carcinomatosis or leptomeningeal metastasis (LM)
Uncommon and late complication of solid tumors and hematological cancers, approximately 5-8% and 5-15% respectively
Most common primary tumors associated with LM are breast, lung, and melanoma
Commonly misdiagnosed due to symptoms mimicking infectious meningitis and chronic headache
Multiple routes tumor cells can gain access to CSF
Most commonly thought to be through hematogenous spread via arachnoid vessels or direct extension from brain parenchyma
Neoplastic meningitis
Migraine headache
Drug induced aseptic meningitis
Tension headache
Primary Amebic Meningoencephalitis
Cluster headache
Primary CNS lymphoma
Meningitis/encephalitis