Annual incidence of degenerative Mitral Valve (MV) disease causing<unk>  ~3% in industrialized countries
Other etiologies of<unk> :
Cardiac ischemia
Endocarditis
Rheumatic disease
SLE, scleroderma, amyloidosis, sarcoidosis
Connective tissue disease (myxomatous degeneration, Marfan, Ehlers-Danlos)
HOCM
Dilated cardiomyopathy
Mitral valve prolapse
Congenital disorders
Criteria for MV repair:
Development of NYHA class II symptoms
Deterioration in LV function
LV end systolic diameter < 4.5 cm with EF > 60% to protect LV function
However, recent evidence suggests best outcomes of MV repair are in asymptomatic or minimally symptomatic patients selected for surgery soon after echo dx
Cardiac ischemia
Endocarditis
Rheumatic disease
SLE, scleroderma, amyloidosis, sarcoidosis
Connective tissue disease (myxomatous degeneration, Marfan, Ehlers-Danlos)
HOCM
Dilated cardiomyopathy
Mitral valve prolapse
Congenital disorders
Development of NYHA class II symptoms
Deterioration in LV function
LV end systolic diameter < 4.5 cm with EF > 60% to protect LV function
Mitral regurgitation
Mitral stenosis
Aortic regurgitation
Mitral valve prolapse
Aortic stenosis
Hypertrophic cardiomyopathy
Restrictive cardiomyopathy
Asymptomatic hypertension