Derived from C. autumnale (wild saffron, meadow saffron, autum crocus, naked lady) and G. superba (glory lily)
C. autumnale resembles wild garlic  C. autumnale
G. superba may be confused for sweet potatoes  G. superba
First published in the first century in Pedanius Dioscorides De Materia Medica
C. autumnale resembles wild garlic  C. autumnale
G. superba may be confused for sweet potatoes  G. superba
Gout
Familial Mediterranean fever
Pericarditis
Inhibitor of microtubule formation and function
Rapidly absorbed in the jenjunum and ileum
Bioavaiability of 25-50%
Lipid soluble
Volume of distribution from 2.2-12L/kg, may increase to 21L/kg in overdose
50% bound to plasma proteins
Peak serum concentration in 1-3 hours
Metabolized by liver via CYP3A4
Undergoes enterohepatic recirculation
Serum half-life 9-108 minutes
Toxicity usually occurs at levels >3ng/ml
Undergoes enterohepatic recirculation
Colchicine toxicity
Aluminum toxicity
NSAID toxicity
Antimony toxicity
Acetaminophen toxicity
Arsenic toxicity
Sulfonylurea toxicity
Barium toxicity