Relapse is associated with use of beta-lactams, cephalosporins, macroides.
Combination therapy to decrease the incidence of relapse and duration recommended at a minimum of 6 weeks
Oral doxycycline (2–4 mg/kg per day, maximum 200 mg/day, in 2 divided doses) or oral
tetracycline (30–40 mg/kg per day, maximum 2 g/day, in 4 divided doses) -and-
Rifampin (15–20 mg/kg per day, maximum 600–900 mg/day, in 1 or 2 divided doses).
Combination therapy with trimethoprim-sulfamethoxazole (TMP-SMZ) can be used if
tetracyclines are contraindicated.
Oral TMP-SMZ (trimethoprim, 10 mg/kg per day, maximum 480 mg/day; and sulfamethoxazole,
50 mg/kg per day, maximum 2.4 g/day) divided in 2 doses for 4 to 6 weeks.
Consider adding rifampin.
Tetracyclines (such as doxycycline) should be avoided in children less than 8 years of age.
Doxycycline x 6 weeks.
Brucella
Psittacosis
Staphylococcus
Anthrax 
Salmonella
Brucellosis 
Legionella
Q fever 