<unk>  = clinical syndrome associated with end-stage renal disease
Correlation exists between symptoms of<unk>  and low GFR (15-20% of nl)
BUN/creatinine are inaccurate markers of clinical syndrome of<unk> 
Contributing Factors:
Excretory failure
Leads to toxin accumulation
Biosynthetic failure
Loss of Vitamin D and erythropoietin
Regulatory failure<unk>  state produces excess free radicals → atherosclerosis, amyloidosis
Correlation exists between symptoms of<unk>  and low GFR (15-20% of nl)
BUN/creatinine are inaccurate markers of clinical syndrome of<unk> 
Excretory failure
Leads to toxin accumulation
Biosynthetic failure
Loss of Vitamin D and erythropoietin
Regulatory failure<unk>  state produces excess free radicals → atherosclerosis, amyloidosis
Leads to toxin accumulation
Loss of Vitamin D and erythropoietin<unk>  state produces excess free radicals → atherosclerosis, amyloidosis
Uremia
Ketoacidosis
Hypercalciuria
Hypernatremia
Renal tubular acidosis
Hyperammonemia
Ketonemia
Lactic acidosis