Labs
CBC
Lymphopenia
Neutrophilia
CMP
Low albumin<unk>  markers (elevated)
CRP
ESR
Fibrinogen
Procalcitonin
D-dimer
Ferritin
LDH
IL-6
BNP
Troponin
CBC
Lymphopenia
Neutrophilia
CMP
Low albumin<unk>  markers (elevated)
CRP
ESR
Fibrinogen
Procalcitonin
D-dimer
Ferritin
LDH
IL-6
BNP
Troponin
Lymphopenia
Neutrophilia
Low albumin
CRP
ESR
Fibrinogen
Procalcitonin
D-dimer
Ferritin
LDH
IL-6
Imaging
Chest X-ray/CT
May show bilateral patchy infiltrates or ground glass opacities
Echocardiogram to evaluate for LV dysfunction, coronary aneurysm/dilation
Chest X-ray/CT
May show bilateral patchy infiltrates or ground glass opacities
Echocardiogram to evaluate for LV dysfunction, coronary aneurysm/dilation
May show bilateral patchy infiltrates or ground glass opacities
CDC12
An individual aged <21 years presenting with feveri, laboratory evidence of inflammation, and evidence of clinically severe illness requiring hospitalization, with<unk>  (>2) organ involvement (cardiac, renal, respiratory, hematologic, gastrointestinal, dermatologic or neurological); AND
No alternative plausible diagnoses; AND
Positive for current or recent SARS-CoV-2 infection by RT-PCR, serology, or antigen test; or COVID-19 exposure within the 4 weeks prior to the onset of symptoms
An individual aged <21 years presenting with feveri, laboratory evidence of inflammation, and evidence of clinically severe illness requiring hospitalization, with<unk>  (>2) organ involvement (cardiac, renal, respiratory, hematologic, gastrointestinal, dermatologic or neurological); AND
No alternative plausible diagnoses; AND
Positive for current or recent SARS-CoV-2 infection by RT-PCR, serology, or antigen test; or COVID-19 exposure within the 4 weeks prior to the onset of symptoms
iFever >38.0°C for ≥24 hours, or report of subjective fever lasting ≥24 hours
iiIncluding, but not limited to, one or more of the following: an elevated C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen, procalcitonin, d-dimer, ferritin, lactic acid dehydrogenase (LDH), or interleukin 6 (IL-6), elevated neutrophils, reduced lymphocytes and low albumin
iFever >38.0°C for ≥24 hours, or report of subjective fever lasting ≥24 hours
iiIncluding, but not limited to, one or more of the following: an elevated C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen, procalcitonin, d-dimer, ferritin, lactic acid dehydrogenase (LDH), or interleukin 6 (IL-6), elevated neutrophils, reduced lymphocytes and low albumin
iFever >38.0°C for ≥24 hours, or report of subjective fever lasting ≥24 hours
iiIncluding, but not limited to, one or more of the following: an elevated C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen, procalcitonin, d-dimer, ferritin, lactic acid dehydrogenase (LDH), or interleukin 6 (IL-6), elevated neutrophils, reduced lymphocytes and low albumin
Some individuals may fulfill full or partial criteria for Kawasaki disease but should be reported if they meet the case definition for MIS-C
Consider MIS-C in any pediatric death with evidence of SARS-CoV-2 infection
Some individuals may fulfill full or partial criteria for Kawasaki disease but should be reported if they meet the case definition for MIS-C
Consider MIS-C in any pediatric death with evidence of SARS-CoV-2 infection
WHO13<unk>  and adolescents 0–19 years of age with fever > 3 days
AND two of the following:
a) Rash or bilateral non-purulent conjunctivitis or muco-cutaneous inflammation signs (oral, hands or feet).
b) Hypotension or shock.
c) Features of myocardial dysfunction, pericarditis, valvulitis, or coronary abnormalities (including ECHO findings or elevated Troponin/NT-proBNP),
d) Evidence of coagulopathy (by PT, PTT, elevated d-Dimers).
e) Acute gastrointestinal problems (diarrhoea, vomiting, or abdominal pain).<unk>  and adolescents 0–19 years of age with fever > 3 days
AND two of the following:
a) Rash or bilateral non-purulent conjunctivitis or muco-cutaneous inflammation signs (oral, hands or feet).
b) Hypotension or shock.
c) Features of myocardial dysfunction, pericarditis, valvulitis, or coronary abnormalities (including ECHO findings or elevated Troponin/NT-proBNP),
d) Evidence of coagulopathy (by PT, PTT, elevated d-Dimers).
e) Acute gastrointestinal problems (diarrhoea, vomiting, or abdominal pain).
a) Rash or bilateral non-purulent conjunctivitis or muco-cutaneous inflammation signs (oral, hands or feet).
b) Hypotension or shock.
c) Features of myocardial dysfunction, pericarditis, valvulitis, or coronary abnormalities (including ECHO findings or elevated Troponin/NT-proBNP),
d) Evidence of coagulopathy (by PT, PTT, elevated d-Dimers).
e) Acute gastrointestinal problems (diarrhoea, vomiting, or abdominal pain).
AND
Elevated markers of inflammation such as ESR, C-reactive protein, or procalcitonin.
AND
No other obvious microbial cause of inflammation, including bacterial sepsis, staphylococcal or streptococcal shock syndromes.
AND
Evidence of COVID-19 (RT-PCR, antigen test or serology positive), or likely contact with patients with COVID-19.
AND
Elevated markers of inflammation such as ESR, C-reactive protein, or procalcitonin.
AND
No other obvious microbial cause of inflammation, including bacterial sepsis, staphylococcal or streptococcal shock syndromes.
AND
Evidence of COVID-19 (RT-PCR, antigen test or serology positive), or likely contact with patients with COVID-19.
Elevated markers of inflammation such as ESR, C-reactive protein, or procalcitonin.
No other obvious microbial cause of inflammation, including bacterial sepsis, staphylococcal or streptococcal shock syndromes.
Evidence of COVID-19 (RT-PCR, antigen test or serology positive), or likely contact with patients with COVID-19.
Multisystem inflammatory syndrome in children
SARS-CoV-2
Seizures in patients with HIV-AIDS
Kawasaki disease
High altitude pharyngitis and bronchitis
Toxic shock syndrome
Pediatric fever of uncertain source
Juvenile idiopathic arthritis