Severe complications of sickle cell disease
Stroke
Acute chest syndrome (reserved for severe cases)
Priapism (conflicting evidence for benefit)
Other complications requiring<unk>  when Hb >10
Toxicities
Sulfhemoglobinemia, severe
Methemoglobinemia in patients with G6PD or with methemoglobinemia due to nitrite treatment of cyanide
Severe hemolysis due to formic acid toxicity
Severe hemolysis due to malaria or babesiosis
Neonatal hyperbilirubinemia,<unk> remely severe or unresponsive to phototherapy
Neonatal polycythemia
Stroke
Acute chest syndrome (reserved for severe cases)
Priapism (conflicting evidence for benefit)
Other complications requiring<unk>  when Hb >10
Sulfhemoglobinemia, severe
Methemoglobinemia in patients with G6PD or with methemoglobinemia due to nitrite treatment of cyanide
Severe hemolysis due to formic acid toxicity
Exchange transfusion
Massive transfusion
Massive transfusion 
Platelet transfusion
Cryoprecipitate transfusion
Fresh frozen plasma
Packed red blood cells
Plasmapheresis