Painful but rarely pruritic
Mucosal involvement common
Presenting complaint in 50% of cases
Primary lesions
Tense and clear vesicles/bullae on head, trunk, mucosa
Become flaccid and turbid 2-3 days later
Rupture and leave sensitive denuded area of skin
Slow to heal and prone to secondary infection
Nikolsky's sign: Sliding pressure applied to normal skin adjacent to blister causes further ulceration
Intraepidermal acantholysis: Keratinocytes separated at the basal layer from one another
Gives appearance of lesion expanding into adjacent tissue
Transudate accumulate between keratinocyte and basement membrane which gives rise to new blisters
Presenting complaint in 50% of cases
Tense and clear vesicles/bullae on head, trunk, mucosa
Become flaccid and turbid 2-3 days later
Rupture and leave sensitive denuded area of skin
Slow to heal and prone to secondary infection
Slow to heal and prone to secondary infection
Intraepidermal acantholysis: Keratinocytes separated at the basal layer from one another
Gives appearance of lesion expanding into adjacent tissue
Transudate accumulate between keratinocyte and basement membrane which gives rise to new blisters
Pemphigus vulgaris
Febrile
Bullous pemphigoid
Diffuse distribution
Toxic epidermal necrolysis
Varicella
Dermatitis herpetiformis
Smallpox