Limited evidence suggests usage of DDAVP in combination with HTS can safely increase sodium, while lowering risk for over-correction
DDAVP prevents free water excretion renally
Give 3% hypertonic saline based on calculations above
Give desmopressin 1-2 µg IV q6 hours
Patients must be PO water restricted
Goal sodium is 6 mEq/L over first 24 hours
DDAVP prevents free water excretion renally
Give 3% hypertonic saline based on calculations above
Give desmopressin 1-2 µg IV q6 hours
Patients must be PO water restricted
Hyponatremia
Thiazide diuretic use
Hypernatremia
Na-wasting nephropathy 
Hypercapnia
Osmotic diuresis 
Hypermagnesemia
Aldosterone deficiency