Progressive muscle atrophy/weakness due to degeneration of upper and lower motor neurons
Patients will rarely present to the ED undiagnosed
Likely related to mutated superoxide dismutase (SOD1) gene
Involvement of the anterior horn cells
Amyotrophic lateral sclerosis
Neuromuscular weakness
Lambert-Eaton myasthenic syndrome
Upper motor neuron:
Polymyositis
CVA
Acute flaccid myelitis
Hemorrhagic stroke