CNS myelin destruction causes variable motor, sensory, visual and cerebellar dysfunction
Relapsing/remitting (most common)
Relapse (days-months) followed by remission
Secondary progressive
Relapses and partial recoveries occur, but disability does not fade away between cycles
Primary progressive
Symptoms progress slowly and steadily without remission
Progressive relapsing
Similar to primary progressive but with superimposed flares
Relapse (days-months) followed by remission
Relapses and partial recoveries occur, but disability does not fade away between cycles
Symptoms progress slowly and steadily without remission
Similar to primary progressive but with superimposed flares
Multiple sclerosis
Neuromuscular weakness
Amyotrophic lateral sclerosis
Upper motor neuron:
Normal pressure hydrocephalus
CVA
Chronic inflammatory demyelinating polyneuropathy
Hemorrhagic stroke