Generally asymptomatic and found on routine lab testing; complications are typically from AT disorders
Thrombosis (leading cause of morbidity and mortality)
Arteries (more common)
Stroke, TIA, MI, unstable angina
Venous system
DVT, PE, Budd-Chiari syndrome
Serious bleeding (less common)
Generally in the nasal and bucchal mucosa and the GI tract
Vasomotor symptoms (due to microvascular disturbances)
Headache, lightheadedness, syncope, acral paresthesia, atypical chest pain, livedo reticularis, erythromelalgia, and transient visual disturbances
Arteries (more common)
Stroke, TIA, MI, unstable angina
Venous system
DVT, PE, Budd-Chiari syndrome
Stroke, TIA, MI, unstable angina
DVT, PE, Budd-Chiari syndrome
Generally in the nasal and bucchal mucosa and the GI tract
Headache, lightheadedness, syncope, acral paresthesia, atypical chest pain, livedo reticularis, erythromelalgia, and transient visual disturbances
Thrombocytosis
Acute blood loss
Thrombocytopenia
Acute hemolytic anemia
Polycythemia
Iron deficiency anemia
Leukopenia
Treatment of vitamin B12 deficiency