2nd most frequently transplanted solid organ
May be from living or deceased donor
Most common causes of<unk>  failure necessitating transplant include hepatitis C or B infection, alcoholic cirrhosis, idiopathic/autoimmune<unk>  disease, primary biliary cirrhosis, primary sclerosing cholangitis, and acute<unk>  failure (e.g. drug/toxin induced, acute hepatitis, etc.)
Balance between immune suppression, rejection and susceptibility to infection
Typical regimen includes: calcineurin inhibitor + antimetabolite + steroid
Calcineurin inhibitor
Cyclosporine
Tacrolimus
Steroids
Prednisone/Prednisolone
+/- Antimetabolite
Azathioprine
Mycophenolate mofetil (MMF)
Calcineurin inhibitor
Cyclosporine
Tacrolimus
Steroids
Prednisone/Prednisolone
+/- Antimetabolite
Azathioprine
Mycophenolate mofetil (MMF)
Cyclosporine
Tacrolimus
Prednisone/Prednisolone
Azathioprine
Mycophenolate mofetil (MMF)
Liver transplant complications
Most common problems in liver transplant patients involve:
Pancreas transplant complications
Acute graft rejection
Kidney transplant complications
1 in 5 have rejection during first year, usually within <1 mo
Ischemic hepatitis
Vascular thrombosis