<unk>  blocks dihydrofolate reductase (DHFR) → blocks conversion of folate to folinic acid
Used in treatment of Non-Hodgkin's lymphoma, acute lymphocytic leukemia, certain other malignancies, psoriasis and other dermatological conditions, rheumatoid arthritis (as a DMARD)
Folate supplementation is often given with<unk> , and ↓ risk of toxicity
Absorbed by saturable transporter in GI tract
Single large oral dose will have lower bioavailability/toxicity than multiple small doses or chronic toxicity.
Single large oral dose will have lower bioavailability/toxicity than multiple small doses or chronic toxicity.
Methotrexate toxicity
Platinum toxicity
Colchicine toxicity
NSAID toxicity
Xylazine toxicity
Depleted uranium toxicity
Aconitum toxicity
Paraneoplastic syndromes