Time to peak and duration of symptoms depends on the half-life of the drug involved
Agitation/restlessness
Anxiety
Muscle aches
Increased tearing
Insomnia
Runny nose
Sweating
Yawning
Skin-Crawling
May be tachycardic and/or tachypneic but not necessarily
Abdominal cramping
Diarrhea
Dilated pupils
Goose bumps
Nausea
Vomiting
Unlike alcohol or benzodiazepine withdrawal, patients rarely have seizures
Altered mental status is also not part of<unk>  signs
Opioid withdrawal
Differential is largely based on clinical symptoms and history
Benzodiazepine withdrawal
Sepsis
Cocaine withdrawal
Influenza
Alcohol withdrawal
Clonidine withdrawal