Half-life: unknown
Metabolism: liver, CYP450: unknown
Excretion: urine, bile
Mechanism of Action: Used by liver for synthesis of some coagulation factors (II,VII,IX,X,C,S). Timing in the synthesis of these factors impacts reversal of elevated INR (~4 hours: F-VII, ~24 hours: F-II).
Vitamin K
Prothrombin complex concentrates
Vitamin B12
Protamine sulfate
Fresh frozen plasma
Blood products
EDTA
Tdap