Pregnancy: C
Lactation: Use caution
Renal Dosing
Adult
If usual dose 500mg q6h
CrCl 60-89: 400mg q6h
CrCl 30-59: 300mg q6h
CrCl 15-29: 200mg q6h
CrCl <15: Avoid unless HD w/in 48h
HD: 200mg q6h, give dose after dialysis, no supplement
PD: No supplement
If usual dose 1000mg q8h
CrCl 60-89: 500mg q6h
CrCl 30-59: 500mg q8h
CrCl 15-29: 500mg q12h
CrCl <15: Avoid unless HD w/in 48h
HD: 500mg q12h, give dose after dialysis, no supplement
PD: No supplement
If usual dose 1000mg q6h
CrCl 60-89: 750mg q8h
CrCl 30-59: 500mg q6h
CrCl 15-29: 500mg q12h
CrCl <15: Avoid unless HD w/in 48h
HD: 500mg q12h, give dose after dialysis, no supplement
PD: No supplement
Pediatric
< 30 kg: Avoid use in renal impairment
> 30 kg:
CrCl 41-70: Decrease dose 50%
CrCl 21-40: Decrease dose 63%; give q8h
CrCl 6-20: Decrease dose 75%, give q12h
CrCl <5: Avoid unless HD w/in 48h
HD: Give dose after dialysis, no supplement
PD: No supplement
Hepatic Dosing
Adult: Not defined
Pediatric: Not defined
Adult
If usual dose 500mg q6h
CrCl 60-89: 400mg q6h
CrCl 30-59: 300mg q6h
CrCl 15-29: 200mg q6h
CrCl <15: Avoid unless HD w/in 48h
HD: 200mg q6h, give dose after dialysis, no supplement
PD: No supplement
If usual dose 1000mg q8h
CrCl 60-89: 500mg q6h
CrCl 30-59: 500mg q8h
CrCl 15-29: 500mg q12h
CrCl <15: Avoid unless HD w/in 48h
HD: 500mg q12h, give dose after dialysis, no supplement
PD: No supplement
If usual dose 1000mg q6h
CrCl 60-89: 750mg q8h
CrCl 30-59: 500mg q6h
CrCl 15-29: 500mg q12h
CrCl <15: Avoid unless HD w/in 48h
HD: 500mg q12h, give dose after dialysis, no supplement
PD: No supplement
Pediatric
< 30 kg: Avoid use in renal impairment
> 30 kg:
CrCl 41-70: Decrease dose 50%
CrCl 21-40: Decrease dose 63%; give q8h
CrCl 6-20: Decrease dose 75%, give q12h
CrCl <5: Avoid unless HD w/in 48h
HD: Give dose after dialysis, no supplement
PD: No supplement
If usual dose 500mg q6h
CrCl 60-89: 400mg q6h
CrCl 30-59: 300mg q6h
CrCl 15-29: 200mg q6h
CrCl <15: Avoid unless HD w/in 48h
HD: 200mg q6h, give dose after dialysis, no supplement
PD: No supplement
If usual dose 1000mg q8h
CrCl 60-89: 500mg q6h
CrCl 30-59: 500mg q8h
CrCl 15-29: 500mg q12h
CrCl <15: Avoid unless HD w/in 48h
HD: 500mg q12h, give dose after dialysis, no supplement
PD: No supplement
If usual dose 1000mg q6h
CrCl 60-89: 750mg q8h
CrCl 30-59: 500mg q6h
CrCl 15-29: 500mg q12h
CrCl <15: Avoid unless HD w/in 48h
HD: 500mg q12h, give dose after dialysis, no supplement
PD: No supplement
CrCl 60-89: 400mg q6h
CrCl 30-59: 300mg q6h
CrCl 15-29: 200mg q6h
CrCl <15: Avoid unless HD w/in 48h
HD: 200mg q6h, give dose after dialysis, no supplement
PD: No supplement
CrCl 60-89: 500mg q6h
CrCl 30-59: 500mg q8h
CrCl 15-29: 500mg q12h
CrCl <15: Avoid unless HD w/in 48h
HD: 500mg q12h, give dose after dialysis, no supplement
PD: No supplement
CrCl 60-89: 750mg q8h
CrCl 30-59: 500mg q6h
CrCl 15-29: 500mg q12h
CrCl <15: Avoid unless HD w/in 48h
HD: 500mg q12h, give dose after dialysis, no supplement
PD: No supplement
< 30 kg: Avoid use in renal impairment
> 30 kg:
CrCl 41-70: Decrease dose 50%
CrCl 21-40: Decrease dose 63%; give q8h
CrCl 6-20: Decrease dose 75%, give q12h
CrCl <5: Avoid unless HD w/in 48h
HD: Give dose after dialysis, no supplement
PD: No supplement
CrCl 41-70: Decrease dose 50%
CrCl 21-40: Decrease dose 63%; give q8h
CrCl 6-20: Decrease dose 75%, give q12h
CrCl <5: Avoid unless HD w/in 48h
HD: Give dose after dialysis, no supplement
PD: No supplement
Adult: Not defined
Pediatric: Not defined
Imipenem/Cilastatin
Ceftolozane/tazobactam
Meropenem
Ampicillin/Sulbactam
Fosfomycin
Piperacillin/Tazobactam
Ertapenem
Vancomycin