Imaging to evaluate for fractures
Initial lesion may be destructive, radiolucent (especially in skull)
Involved<unk> s may be expanded, abnormally dense
May have multiple fissure fractures in long<unk> s
Alk phos typically very high
Serum calcium may be high
Initial lesion may be destructive, radiolucent (especially in skull)
Involved<unk> s may be expanded, abnormally dense
May have multiple fissure fractures in long<unk> s
Paget's disease of bone
Bone tumor 
Ewing sarcoma
Multiple myeloma, myelofibrosis
Osteogenesis imperfecta
Fibrous dysplasia
Myositis ossificans
Intramedullary osteosclerosis