Hepatomegaly and/or splenomegaly with weight loss, abdominal distension or abdominal pain
Lymphadenopathy
Fever
Bleeding (petechiae, purpura), low platelet count, anemia
MSK pain, limp, refusal to bear weight
Larger anterior mediastinal mass could cause SVC syndrome
Pallor, fatigue, easy bleeding, fever, infection
Bone pain/arthralgia
Hepatomegaly or splenomegaly
Clinically significant when WBC > 200K in AML, >300K in ALL
Cerebral circulation: headache, altered mental status, visual disturbances, seizure, CVA
Pulmonary circulation: shortness of breath, hypoxemia
Tumor lysis syndrome
Neutropenic fever, Sepsis, overall increased risk of infection
Neutropenic enterocolitis (typhlitis)
Leukostasis and hyperleukocytosis
Hyperviscosity syndrome
Thromboembolism
Treatment-related complications
Chemotherapy-induced nausea and vomiting
Cytokine release syndrome
Chemotherapeutic drug extravasation
Differentiation syndrome (retinoic acid syndrome) in APML
Stem cell transplant complications
Catheter-related complications
Tunnel infection
Exit site infection
CVC obstruction (intraluminal or catheter tip thrombosis)
Catheter-related venous thrombosis
Fracture of catheter lumen
Neutropenic enterocolitis (typhlitis)
Chemotherapy-induced nausea and vomiting
Cytokine release syndrome
Chemotherapeutic drug extravasation
Differentiation syndrome (retinoic acid syndrome) in APML
Stem cell transplant complications
Catheter-related complications
Tunnel infection
Exit site infection
CVC obstruction (intraluminal or catheter tip thrombosis)
Catheter-related venous thrombosis
Fracture of catheter lumen
Tunnel infection
Exit site infection
CVC obstruction (intraluminal or catheter tip thrombosis)
Catheter-related venous thrombosis
Fracture of catheter lumen
Leukemia 
Leukemias will often involve >1 cell line; other conditions restricted to single line
Leukopenia
Aplastic anemia
Acute myeloid leukemia
Iron deficiency anemia
Myelofibrosis
Viral infection 