Coverage for Pasteurella, Strep, and Staph
Consider for high-risk wounds
wounds reaching the level of the muscle/tendon, wounds to the hand, violation of bone or joint capsule, immunocompromised hosts, wounds associated with significant local edema
Amoxicilin-clavulanate 875mg PO BID x 5-7 days OR
Doxycycline 100mg PO BID x 14 days if penicillin allergic 
Clindamycin 450mg (5mg/kg) PO q8hrs daily x7 days PLUS
Ciprofloxacin 500mg PO q12hrs x 7 days OR
TMP/SMX 2DS tabs (5mg/kg) PO q12hrs
wounds reaching the level of the muscle/tendon, wounds to the hand, violation of bone or joint capsule, immunocompromised hosts, wounds associated with significant local edema
Ciprofloxacin 500mg PO q12hrs x 7 days OR
TMP/SMX 2DS tabs (5mg/kg) PO q12hrs
All human bites should be strongly considered for antibiotic therapy.
Requires polymicrobial coverage for: S. aureus, Strep Viridans, Bacteroides, Coagulase-neg Staph, Eikenella, Fusobacterium, Cornebacterium, peptostreptococus
Amoxicilin-clavulanate 875mg PO BID x 5-7days OR
Clindamycin 450mg (5mg/kg) PO q8hrs daily x7 days PLUS
Ciprofloxacin 500mg PO q12hrs x 7 days OR
TMP/SMX 2DS tabs (5mg/kg) PO q12hrs
Ciprofloxacin 500mg PO q12hrs x 7 days OR
TMP/SMX 2DS tabs (5mg/kg) PO q12hrs
Ampicillin/Sulbactam 3g IV (50mg/kg IV) q 6hrs daily OR
Cefoxitin 1g IV q8hrs (25mg/kg q6hrs) OR
Pipericillin/Tazobactam 4.5g IV (80mg/kg IV) q8hrs OR
Ceftriaxone 1g (50mg/kg IV) once + Metronidazole 500mg IV q8hrs OR
Clindamycin 600mg IV q8hrs PLUS
TMP/SMX 5mg/kg IV q12hrs OR
Ciprofloxacin 400mg IV q12hrs OR
TMP/SMX 5mg/kg IV q12hrs OR
Ciprofloxacin 400mg IV q12hrs OR
Environmental exposure antibiotics
Immunocompromised antibiotics
Post exposure prophylaxis antibiotics
Environmental heat diagnoses
Healthcare occupational exposure to blood or other body fluids
Pregnancy and lactation drug labeling
Pediatric antibiotics
Pulmonary chemical agents