ABC’s and resuscitation if necessary, 2 large bore IVs
Emergent hematology consultation if patient is very ill appearing
HUS
Supportive Care
Hydration
Pain control
Hemodialysis if acute renal failure
Do NOT give antibiotics: results in increased expression of Shiga Toxin from E. Coli O157:H7
TTP
Avoid platelet transfusion, except in life-threatening bleeding or intracranial hemorrhage
Plasma exchange
If Plasma exchange cannot be performed immediately, give FFP and plasmapharese later.
Factor VIII concentrate
DIC
Platelet transfusion if count is <50,000 and/or significant bleeding
pRBC if active bleeding or hemodynamically unstable
FFP if active bleeding
Cryoprecipitate if fibrinogen <150 and bleeding
TXA is only indicated for active or massive bleeding
Malignant hypertension
Reduce blood pressure as clinically indicated
Supportive Care
Hydration
Pain control
Hemodialysis if acute renal failure
Do NOT give antibiotics: results in increased expression of Shiga Toxin from E. Coli O157:H7
Hydration
Pain control
Avoid platelet transfusion, except in life-threatening bleeding or intracranial hemorrhage
Plasma exchange
If Plasma exchange cannot be performed immediately, give FFP and plasmapharese later.
Factor VIII concentrate
Platelet transfusion if count is <50,000 and/or significant bleeding
pRBC if active bleeding or hemodynamically unstable
FFP if active bleeding
Cryoprecipitate if fibrinogen <150 and bleeding
TXA is only indicated for active or massive bleeding
Reduce blood pressure as clinically indicated
Warm antibody autoimmune<unk> 
High-dose corticosteroids PO (1-2mg/kg per day for 3-4 weeks)
Monoclonal antibodies and immunosuppressive agents
Plasma exchange for severe hemolysis
Allogeneic RBC transfusion for life-threatening anemia
High-dose corticosteroids PO (1-2mg/kg per day for 3-4 weeks)
Monoclonal antibodies and immunosuppressive agents
Plasma exchange for severe hemolysis
Allogeneic RBC transfusion for life-threatening anemia
Malaria
Visit CDC website to determine resistance pattern: https://www.cdc.gov/malaria/diagnosis_treatment/treatment.html
CDC Malaria Hotline: (770) 488-7788 or (855) 856-4713 toll-free Monday-Friday 9 am to 5 pm EST - (770) 488-7100 after hours, weekends and holidays
Babesiosis
Mild/moderate Disease
Atovaquone 750mg PO q12hr AND
Azithromycin 500mg PO on day 1, then 250mg/day PO
Severe Disease
Clindamycin 300-600mg IV QID OR 600mg PO TID AND
Quinine 650mg PO TID x7-10 days
Consider exchange transfusion if parasitemia >10%
Supportive treatment
Visit CDC website to determine resistance pattern: https://www.cdc.gov/malaria/diagnosis_treatment/treatment.html
CDC Malaria Hotline: (770) 488-7788 or (855) 856-4713 toll-free Monday-Friday 9 am to 5 pm EST - (770) 488-7100 after hours, weekends and holidays
Mild/moderate Disease
Atovaquone 750mg PO q12hr AND
Azithromycin 500mg PO on day 1, then 250mg/day PO
Severe Disease
Clindamycin 300-600mg IV QID OR 600mg PO TID AND
Quinine 650mg PO TID x7-10 days
Consider exchange transfusion if parasitemia >10%
Supportive treatment
Atovaquone 750mg PO q12hr AND
Azithromycin 500mg PO on day 1, then 250mg/day PO
Clindamycin 300-600mg IV QID OR 600mg PO TID AND
Quinine 650mg PO TID x7-10 days
Consider exchange transfusion if parasitemia >10%
Brown recluse spider bite
Supportive care
Hemodynamic support with fluids and pressers if necessary
Blood product transfusion if necessary
Supportive care
Hemodynamic support with fluids and pressers if necessary
Blood product transfusion if necessary
Hemodynamic support with fluids and pressers if necessary
Blood product transfusion if necessary
G6PD
Stop new medications
Treat any infections aggressively
Ovoid oxidant drugs
Blood transfusion if severe illness
Sickle Cell Disease, Thalassemia, Hereditary spherocytosis<unk>  in the above diseases typically chronic, usually does not require treatment in ED
Stop new medications
Treat any infections aggressively
Ovoid oxidant drugs
Blood transfusion if severe illness<unk>  in the above diseases typically chronic, usually does not require treatment in ED
Hemolytic anemia
HUS
Autoimmune hemolytic anemia
TTP
Microangiopathic hemolytic anemia
DIC
Bandemia
Hypertensive emergency