Multi-organ system dysfunction
Classic triad: hypoxemia, neurological abnormalities and petechiae
Neuro findings included: focal deficits, altered mental status, coma
Thrombocytopenia and anemia common
Can progress to DIC
Fulminant cases: RV dysfunction, biventricular failure, ARDS, shock, death
Other etiologies (uncommon): pancreatitis, sickle cell crisis, alcoholic liver disease, bone marrow harvest/transplant/liposuction
Fat embolism syndrome
Pulmonary embolism
Immersion pulmonary edema
ARDS
Acute chest syndrome
Pulmonary edema
Aspiration pneumonia and pneumonitis
Diffuse alveolar hemorrhage