CBC, CMP, arterial lactate, CRP
Blood glucose
Urinalysis/urine culture
CXR
CSF
Blood cultures
Requires > or equal to 2 of 4 requirements, with abnormal temperature or WBC required
Temperature >100.4 or <96.8
Age specific tachycardia or bradycardia <10th % for age <1 year
RR >2 SD above the norm
WBC elevated or depressed, based on age, or >10% bands
Cardiovascular organ dysfunction
Respiratory distress
OR
CNS dysfunction - GCS <11 or >3 loss from baseline
Platelets <80 or >50% decrease from baseline
Creatinine >2x upper limit of normal/baseline
Total bilirubin >4 or ALT >2x normal
Hypotension<5th % for age, or SBP <2 SD below normal for age
OR
Need for vasoactive drugs to maintain BP
OR
Metabolic acidosis base deficit >5
Arterial lactate >2x normal
UOP <0.5 mL/kg/hr
Capillary refill >5 sec
Core to peripheral temperature gap >3 degrees C
DESPITE IVF resuscitation >40mL/kg in 1 hour
Sepsis 
THE MISFITS [1]
Tumor lysis syndrome
Trauma
Hemorrhagic shock
Heart
Toxic shock syndrome
Congenital heart disease