Consultation with Infectious Disease should be considered since there are increasingly multidrug resistant strains of S. Typhi and coinfection with diseases such as Malaria may complicate treatment.  The therapy favors the use of fluorquinolones unless suspected or known resistance.
Ciprofloxacin 500-750 mg PO q 12 hrs x 14 days
Ciprofloxacin 400 mg IV q 12 hrs x 10 days
Ceftriaxone 2mg IV q 24 hrs x 14 days
Cefixime 10-15 mg/kg IV q 12 hrs x 8 days
Azithromycin 1 g PO daily x 5 days
If associated delirium, coma, shock, and/or DIC: Dexamethasone 3mg/kg IV load over 30 minutes, then 1mg/kg IV every 6 hours x 8 doses
Typhoid fever
Viral hepatitis
Yellow fever
Amebic Liver Abscess
Murine typhus
Infectious enteritis
Drug fever
Normal causes of acute fever!