15-20mg/kg IV loading dose
Sample Loading Dose Table (individual ED guidelines may differ)
>40kg:  750mg IV
40-59kg:  1000mg IV
60-90kg:  1500mg IV
>90kg:  2000mg IV
Alternative loading dose for serious infections: 20-25mg/kg IV
Loading doses of 30mg/kg has shown improved target trough levels at 12 hrs with no difference in nephrotoxicity
Adjust maintenance dose based on serum levels
>40kg:  750mg IV
40-59kg:  1000mg IV
60-90kg:  1500mg IV
>90kg:  2000mg IV
All: Adjust repeat doses based on serum levels
<50kg:  500mg IV q12h
50-69kg:  750mg IV q12h
>70kg:  1000mg IV q12h
Alternative (All Weights): 10-15mg/kg IV q12
Adjust dose based on serum levels
1st occurrence
Uncomplicated: 125mg PO q6h x 10-14 days
Complicated:  500mg PO/NG q6h
May use in combo with metronidazole IV
Consider adding<unk>  500mg PR q6 if complete ileus
2nd occurrence
Uncomplicated: 125mg PO q6h x 10-14 days
Complicated:  500mg PO/NG q6h
May use in combo with metronidazole IV
Consider adding<unk>  500mg PR q6 if complete ileus
3rd+ occurrence
125mg PO q6h x 10-14 days, then daily x 7 days, then q2-3 days x 2-8 wk
Uncomplicated: 125mg PO q6h x 10-14 days
Complicated:  500mg PO/NG q6h
May use in combo with metronidazole IV
Consider adding<unk>  500mg PR q6 if complete ileus
May use in combo with metronidazole IV
Consider adding<unk>  500mg PR q6 if complete ileus
Uncomplicated: 125mg PO q6h x 10-14 days
Complicated:  500mg PO/NG q6h
May use in combo with metronidazole IV
Consider adding<unk>  500mg PR q6 if complete ileus
May use in combo with metronidazole IV
Consider adding<unk>  500mg PR q6 if complete ileus
125mg PO q6h x 10-14 days, then daily x 7 days, then q2-3 days x 2-8 wk
500-2000mg/day PO divided q6-8h x 7-10 days
First Dose: 500mg PO x 1
Vancomycin
Meropenem
Ertapenem
Teicoplanin
Aztreonam
Fosfomycin
Linezolid
Ceftazidime