Three recognized patterns of<unk>  - "Acute", "Acute-on-chronic", and "Chronic".
Occurs in patients not previously receiving<unk>  (i.e. with no current body stores)
Serum concentrations can fall rapidly as<unk>  redistributes to tissues, and serum level does not correlate with degree of toxicity. GI symptoms predominate.
GI - nausea/vomiting, diarrhea, abdominal pain
Earliest and most common symptoms
Cardiac effects - bradycardia, QT prolongation, T-wave flattening or inversion
Can also cause Brugada-like ECG pattern
CNS Depression - late finding (takes time for<unk>  to distribute to CNS), indicates progression of toxicity
Earliest and most common symptoms
Can also cause Brugada-like ECG pattern
Also called "Acute-on-therapeutic", occurs in patients currently taking<unk>  due to acute ingestion of supra-therapeutic doses.
Symptoms are a mix of both acute and chronic - includes both GI and CNS effects
Occurs insidiously in patients on chronic<unk>  therapy. Toxicity is secondary to increased absorption or decreased elimination. CNS symptoms predominate.
Chronic<unk>  therapy is associated with nephrogenic diabetes insipidus, which → hypernatremia, fluid loss → ↑<unk>  levels (can precipitate toxicity)
Neurotoxicity is major finding, and is generally more profound than that seen in acute toxicity
Mild symptoms include tremor, drowsiness
Progressive symptoms include hyperreflexia, confusion, ataxia, seizures, extrapyramidal symptoms, coma
Hypothyroidism<unk>  inhibits thyroid hormone release)
Mild symptoms include tremor, drowsiness
Progressive symptoms include hyperreflexia, confusion, ataxia, seizures, extrapyramidal symptoms, coma
Persistent sequelae of<unk> 
Defined as neurologic dysfunction persisting > 2 months after cessation of<unk>  therapy
Exact mechanism unknown (possibly related to CNS demyelination).
Symptoms
Cerebellar dysfunction (dysarthria, ataxia, tremor, gait instability)
Peripheral neuropathy
Extrapyramidal symptoms
Brainstem dysfunction
Dementia
Cerebellar dysfunction (dysarthria, ataxia, tremor, gait instability)
Peripheral neuropathy
Extrapyramidal symptoms
Lithium toxicity
Aluminum toxicity
Antipsychotic toxicity
Antimony toxicity
Gamma hydroxybutyrate withdrawal
Arsenic toxicity
Benzodiazepine toxicity
Barium toxicity