Consider hospitalization for:
Marked increase in intensity of symptoms (e.g. sudden development of resting dyspnea)
Background of severe<unk> 
Worsening hypoxia or hypercarbia (from baseline)
Onset of new physical signs (e.g., cyanosis, peripheral edema)
Failure of<unk>  to respond to initial medical management
Significant comorbidities
Newly occurring arrhythmias
Diagnostic uncertainty
Older age
Insufficient home support
COPD exacerbation
Pulmonary
Acute asthma exacerbation
Airway obstruction
Acute asthma exacerbation 
Anaphylaxis
Aspiration pneumonia and pneumonitis
Angioedema