Any prior ICH
Known structural cerebral vascular lesion (AVM)
Known intracranial neoplasm
Ischemic stroke within 3 mo
Active internal bleeding (excluding menses)
Suspected aortic dissection or pericarditis
Severe uncontrolled BP (>180/110)
History of chronic severe poorly controlled hypertension
History of prior ischemic stroke >3 mo
Known intracranial pathology not covered in absolute contraindications
Current use of anticoagulants with known INR >2–3
Known bleeding diathesis
Recent trauma (past 2 wk)
Prolonged CPR (>10 min)
Major surgery (<3 wk)
Noncompressible vascular punctures (e.g. IJ, subclavian)
Recent internal bleeding (within 2–4 wk)
Patients treated previously with streptokinase should not receive streptokinase a 2nd time
Pregnancy
Active peptic ulcer disease
Other medical conditions likely to increase risk of bleeding (diabetic retinopathy, etc)
Thrombolytics for STEMI
Thrombolytics for pulmonary embolism
Formal echocardiography
Cardiovascular antibiotics
Resuscitative endovascular balloon occlusion of the aorta
Thrombolytics for acute ischemic stroke
Pericardiocentesis
Defibrillation