Pregnancy Rating:
Adverse events have been observed in animal studies
Lactation:
Unknown if excreted in breast milk. Manufacturer recommends to use caution when giving to nursing women.
Renal Dosing
Adult
CrCl > 50 mL/minute: No dosage adjustment necessary
CrCl > 30 to ≤ 50 mL/minute: 400 mg every 12 hours
CrCl ≥ 15 to ≤ 30 mL/minute: 300 mg every 12 hours
CrCl < 15 mL/minute: 200 mg every 12 hours
ESRD patients on hemodialysis: 200 mg every 12 hours; dose given after hemodialysis on dialysis days
Pediatric
≥ 2 months to < 18 years of age
CrCl > 50 mL/minute/1.73 m²: No adjustment necessary
CrCl ≤ 50 mL/minute/1.73 m²: Insufficient data, use with caution, dosing adjustment may be necessary
≥ 18 years of age - same as adult dosing
Hepatic Dosing
Adult
No dosage adjustment in manufacturer's labeling. Has not been studied.
Pediatric
No dosage adjustment in manufacturer's labeling. Has not been studied.
Adverse events have been observed in animal studies
Unknown if excreted in breast milk. Manufacturer recommends to use caution when giving to nursing women.
Adult
CrCl > 50 mL/minute: No dosage adjustment necessary
CrCl > 30 to ≤ 50 mL/minute: 400 mg every 12 hours
CrCl ≥ 15 to ≤ 30 mL/minute: 300 mg every 12 hours
CrCl < 15 mL/minute: 200 mg every 12 hours
ESRD patients on hemodialysis: 200 mg every 12 hours; dose given after hemodialysis on dialysis days
Pediatric
≥ 2 months to < 18 years of age
CrCl > 50 mL/minute/1.73 m²: No adjustment necessary
CrCl ≤ 50 mL/minute/1.73 m²: Insufficient data, use with caution, dosing adjustment may be necessary
≥ 18 years of age - same as adult dosing
CrCl > 50 mL/minute: No dosage adjustment necessary
CrCl > 30 to ≤ 50 mL/minute: 400 mg every 12 hours
CrCl ≥ 15 to ≤ 30 mL/minute: 300 mg every 12 hours
CrCl < 15 mL/minute: 200 mg every 12 hours
ESRD patients on hemodialysis: 200 mg every 12 hours; dose given after hemodialysis on dialysis days
≥ 2 months to < 18 years of age
CrCl > 50 mL/minute/1.73 m²: No adjustment necessary
CrCl ≤ 50 mL/minute/1.73 m²: Insufficient data, use with caution, dosing adjustment may be necessary
≥ 18 years of age - same as adult dosing
CrCl > 50 mL/minute/1.73 m²: No adjustment necessary
CrCl ≤ 50 mL/minute/1.73 m²: Insufficient data, use with caution, dosing adjustment may be necessary
Adult
No dosage adjustment in manufacturer's labeling. Has not been studied.
Pediatric
No dosage adjustment in manufacturer's labeling. Has not been studied.
No dosage adjustment in manufacturer's labeling. Has not been studied.
No dosage adjustment in manufacturer's labeling. Has not been studied.
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