Treat shock
Treat underlying infection
Necrotic tissue may require debridement
Coagulopathy correction, in some cases
Typically only if bleeding or need for procedure
Exception: FFP usually indicated for neonatal<unk> 
Cryoprecipitate: consider if fibrinogen <100
Platelets: consider repletion if <50K with bleeding or <20K without bleeding
FFP: consider repletion to goal of PT and PTT < 1.5 times the normal limit
Vitamin K, folate
Typically only if bleeding or need for procedure
Exception: FFP usually indicated for neonatal<unk> 
Cryoprecipitate: consider if fibrinogen <100
Platelets: consider repletion if <50K with bleeding or <20K without bleeding
FFP: consider repletion to goal of PT and PTT < 1.5 times the normal limit
Vitamin K, folate
Exception: FFP usually indicated for neonatal<unk>
Purpura fulminans
Febrile, toxic
Pyoderma gangrenosum
Palpable
Cutaneous larva migrans
Meningococcemia
Drug rash
Disseminated gonococcal infection