Fever
Acute chest syndrome is suspected
Sepsis, osteomyelitis, or other serious infection is suspected
Priapism, aplastic crisis, hypoxia
WBC >30K
Platelet <100K
Pain is not under control after 2-3 rounds of analgesics in ED
<1yr old
Pain is under control and patient can take oral fluids and medications
Ensure appropriate oral analgesics are available
Provide home care instructions
Ensure resource for follow-up
Sickle cell crisis
Vaso-occlusive pain crisis
Aplastic crisis
Bony infarction
Dialysis disequilibrium syndrome
Dactylitis
Hemolytic uremic syndrome
Avascular necrosis of femoral head