Focus on aggressive supportive care and hemodynamic stabilization with early pyridoxine administration
Pyridoxine does not reverse hepatic injury that can result from chronic toxicity.
If ingestion occurred within an hour of presentation, activated charcoal with cathartics may be necessary to restrict absorption and to facilitate excretion via the GI tract
May not be effective but will activate the GABA receptors and halt seizure activity
Known INH quantity ingested - treat with with a 1:1 ingested<unk> :administered pyridoxine dose ratio
Unknown INH quantity ingested - treat with empiric 5g of pyridoxine
Children - start 70mg/kg (max 5 gm)
IV infusion rate is 1 g/min until the seizures stop or the maximum dose is reached. Remainder of dose infused over 4 to 6 hours
Pyridoxine administration may temporarily worsen the metabolic acidosis
If seizures persist repeat dosing is encouraged based on initial dosing.
Oral tablets may be only form of pyridoxine available at many hospitals. The tablets can be crushed and administered with fluids via a nasogastric tube while arranging for transfer. 
Can clear lactate and<unk>  from the bloodstream effectively and can be used as a final measure to increase clearance if needed.
Isoniazid toxicity
Theophylline toxicity
Arsenic toxicity
Ipecac toxicity
Mold toxicity
Xylazine toxicity
Aluminum toxicity
Paraquat toxicity