Priority: Manage pulmonary hemorrhage and renal insufficiency
Difficult airway: Diffuse alveolar hemorrhage and subglottic stenosis
Fiberoptic intubation through LMA advocated
Rheumatology consult + multidisciplinary consults
Mild disease: Corticosteroids and methotrexate
No active glomerulonephritis or organ-threatening disease
Mod-Severe disease: Corticosteroids and cyclophosphamide or rituximab
Corticosteroids:
Methylprednisolone (7-15mg/kg/d with max 1000mg)
Prednisone 1mg/kg/d (max 80mg)
Methotrexate: 20-25mg weekly PO or SC
Cyclophosphamide: 2mg/kg/d PO or 15mg/kg q2 weeks x3 then q3 weeks
Rituximab: 357mg/m² weekly x 4
To consider plasma exchange: Severe/rapidly progressive renal disease, concurrent anti-GBM Ab disease, severe pulmonary hemorrhage
Difficult airway: Diffuse alveolar hemorrhage and subglottic stenosis
Fiberoptic intubation through LMA advocated
Fiberoptic intubation through LMA advocated
No active glomerulonephritis or organ-threatening disease
Methylprednisolone (7-15mg/kg/d with max 1000mg)
Prednisone 1mg/kg/d (max 80mg)
Granulomatosis with polyangiitis
Polyarteritis nodosa, Eosinophilic granulomatosis with polyangiitis 
Polyarteritis nodosa
Lymphoma, lung cancer
Thromboangiitis obliterans
Pneumonia, infective endocarditis, HUS
Eosinophilic granulomatosis with polyangiitis
Glomerulonephritis