Usually begins as a painless nodule <5cm in diameter,<unk> t also may initially present as papules, plaques, or edematous lesions
Limbs are most frequently involved, although it may also affect the head, neck, trunk, and genitals
Initial lesion usually breaks down after days to weeks, forming an ulcer with characteristic undermined edges
Ulceration tends to progress slowly and painlessly, usually systemic symptoms are not present unless there is secondary bacterial infection
However, some individuals may present with an initial edematous lesion that will have relatively rapid progression leading to ulceration within a few days, these patients also often have pain and a low grade fever
Superficial lesions can progress to deeper tissues (i.e. tendons, bones)
Buruli ulcer
Eumycetoma
Lichen planus
Pyoderma gangrenosum
Lichen sclerosus
Venous stasis ulcer
Condyloma acuminata
Diabetic skin ulceration