Age 20-30s most commonly
More common in Turkey, Japan, Middle East
Triad: Recurrent oral aphthous ulcers, genital ulcers, and uveitis
Classically painful ulcer with necrotic center and red rim
Skin: Subcutaneous nodules, pyoderma gangrenosum, cutaneous thrombophlebitis, pustular acne-like folliculitis
Ocular: Uveitis, iritis, optic neuritis, vision loss, hypopyon
Neurologic: Brainstem and corticospinal tract syndromes, aseptic meningoencephalitis, increased ICP, cerebral sinus thrombosis, optic nerve ischemia
GI: Ulcers, obstruction, ileocecal perforation
Inflammatory oligoarthritis
Vasculopathy: Aneurysm, vasculitis, superficial thrombophlebitis, thrombosis
Cardiac: Myocarditis, endocarditis, pericarditis
Renal: Glomerulonephritis, amyloidosis
Pulmonary: Pleural effusions, pulmonary hypertension, pulmonary aneurysm
Behçet's disease
HSV
Chagas disease
Lichen planus
Sjögren syndrome
Pemphigus vulgaris
CMV colitis
Bullous pemphigoid