Severe burning pain in the hands or feet accompanied by a reddish or bluish coloration of the skin
Suspected with any combination of the following: 
Abnormally elevated hemoglobin levels (>18 g/dL in men; 16 g/dL in women)
Normal oxygen saturation
Bleeding complications
Portal vein thrombosis
Splenomegaly
Plethora
Pruritus after bathing
May develop hyperviscosity syndrome
Abnormally elevated hemoglobin levels (>18 g/dL in men; 16 g/dL in women)
Normal oxygen saturation
Bleeding complications
Portal vein thrombosis
Splenomegaly
Plethora
Pruritus after bathing
Polycythemia vera
Primary polycythemia 
Aplastic anemia
Essential thrombocytosis
Essential thrombocytosis 
Myelofibrosis
Chronic myelogenous leukemia 
Immune thrombocytopenic purpura