Lennox-Gaustaut: Oral (Immediate release formulation)
Non-enzyme inducing AED adjuncts: Week 1-2, 25mg qday, week 3-4, 50mg qday, then increased by 50mg qday every 1-2 weeks; maintenance 225-375mg daily in 2 divided doses
Valproate adjunct: Week 1-2, 25mg qod, week 3-4, 25mg qday, then increased by 25-50mg qday every 1-2 weeks; maintenance 100-400mg daily
Enzyme inducing AED adjunct: Week 1-2, 50mg qday, week 3-4, 50mg bid, then increased by 100mg qday every 1-2 weeks; maintenance 300-500mg daily in 2 divided doses
Non-enzyme inducing AED adjuncts: Week 1-2, 25mg qday, week 3-4, 50mg qday, then increased by 50mg qday every 1-2 weeks; maintenance 225-375mg daily in 2 divided doses
Valproate adjunct: Week 1-2, 25mg qod, week 3-4, 25mg qday, then increased by 25-50mg qday every 1-2 weeks; maintenance 100-400mg daily
Enzyme inducing AED adjunct: Week 1-2, 50mg qday, week 3-4, 50mg bid, then increased by 100mg qday every 1-2 weeks; maintenance 300-500mg daily in 2 divided doses
Partial seizures and primary generalized tonic-clonic seizures
Immediate release formulation: same as for Lennox-Gaustaut dosing
Extended release formulation:
Non-enzyme inducing AED adjuncts: Week 1-2, 25mg qday, week 3-4, 50mg qday, week 5, 100mg qday, week 6, 150mg qday, week 7, 200mg qday, week 8 and beyond, dose increases should not exceed 100mg qday at weekly intervals; maintenance 300-400mg daily
Valproate adjunct: Week 1-2, 25mg qod, week 3-4, 25mg qday, week 5, 50mg qday, week 6, 100mg qday, week 7, 150mg qday, week 8 and beyond, does increases should not exceed 100mg qday at weekly intervals; maintenance 200-250mg daily
Enzyme inducing AED adjunct: Week 1-2, 50mg qday, week 3-4, 100mg qday, week 5, 200mg qday, week 6, 300g qday, week 7, 400mg qday, week 8 and beyond, dose increases should not exceed 100mg qday at weekly intervals; maintenance 400-600mg daily
Immediate release formulation: same as for Lennox-Gaustaut dosing
Extended release formulation:
Non-enzyme inducing AED adjuncts: Week 1-2, 25mg qday, week 3-4, 50mg qday, week 5, 100mg qday, week 6, 150mg qday, week 7, 200mg qday, week 8 and beyond, dose increases should not exceed 100mg qday at weekly intervals; maintenance 300-400mg daily
Valproate adjunct: Week 1-2, 25mg qod, week 3-4, 25mg qday, week 5, 50mg qday, week 6, 100mg qday, week 7, 150mg qday, week 8 and beyond, does increases should not exceed 100mg qday at weekly intervals; maintenance 200-250mg daily
Enzyme inducing AED adjunct: Week 1-2, 50mg qday, week 3-4, 100mg qday, week 5, 200mg qday, week 6, 300g qday, week 7, 400mg qday, week 8 and beyond, dose increases should not exceed 100mg qday at weekly intervals; maintenance 400-600mg daily
Non-enzyme inducing AED adjuncts: Week 1-2, 25mg qday, week 3-4, 50mg qday, week 5, 100mg qday, week 6, 150mg qday, week 7, 200mg qday, week 8 and beyond, dose increases should not exceed 100mg qday at weekly intervals; maintenance 300-400mg daily
Valproate adjunct: Week 1-2, 25mg qod, week 3-4, 25mg qday, week 5, 50mg qday, week 6, 100mg qday, week 7, 150mg qday, week 8 and beyond, does increases should not exceed 100mg qday at weekly intervals; maintenance 200-250mg daily
Enzyme inducing AED adjunct: Week 1-2, 50mg qday, week 3-4, 100mg qday, week 5, 200mg qday, week 6, 300g qday, week 7, 400mg qday, week 8 and beyond, dose increases should not exceed 100mg qday at weekly intervals; maintenance 400-600mg daily
Lamotrigine
Topiramate
Ethosuximide
Carbamazepine
Levetiracetam
Phenytoin
Oxcarbazepine
Valproic acid