Cutaneous disease
Painful, edematous, and erythematous papules, plaques, or nodules
Often exhibit a mamillated surface with significant superficial dermal edema leading to pseudovesicular quality
Usually upper extremities > lower extremities, with asymmetrical distribution
Extracutaneous disease: neutrophilic infiltration of organ systems
Ocular infiltration (most common): conjunctivitis, scleritis, keratitis, iritis
Muscular system:  arthralgias, arthritis, myalgia
Less commonly CNS, cardiovascular system, pulmonary system, liver, intestines, kidneys, bones
Fever and leukocytosis
Painful, edematous, and erythematous papules, plaques, or nodules
Often exhibit a mamillated surface with significant superficial dermal edema leading to pseudovesicular quality
Usually upper extremities > lower extremities, with asymmetrical distribution
Ocular infiltration (most common): conjunctivitis, scleritis, keratitis, iritis
Muscular system:  arthralgias, arthritis, myalgia
Less commonly CNS, cardiovascular system, pulmonary system, liver, intestines, kidneys, bones
Sweet's syndrome
Infectious
Staphylococcal scalded skin syndrome
Adenovirus
Rabies
Arbovirus
Drug rash
EBV