Used in the manufacture of munitions, as a dye, a wood preserver, herbicide and photograph developer
Can lead to unintentional exposures
Discovered as a weight loss drug in 1930's but banned by FDA soon afterwards due to side effects
Now banned in US and UK as weight loss drug, labeled "not fit for human consumption"
Able to purchase DNP online in mass quantities
Typically used by body builders for weight loss
Suicidal intentional ingestion
Increase in number of deaths in recent years
Case reports indicate that 20–50mg per kilogram of body weight in humans can be lethal
Can lead to unintentional exposures
Typically used by body builders for weight loss
Suicidal intentional ingestion
Increase in number of deaths in recent years
Uncouples oxidative phosphorylation
Allows increase in basal leak of protons (H+) accross the mitochondrial membrane which is dissipated as heat and leads to hyperthermia
Stimulation of glycolysis in small doses
Allows increase in basal leak of protons (H+) accross the mitochondrial membrane which is dissipated as heat and leads to hyperthermia
Dinitrophenol toxicity
Critical
Acrylonitrile toxicity
Sepsis
Carbon disulfide toxicity
PNA with respiratory failure
Lewisite toxicity
Peritonitis