HIT with thrombosis: 2 mcg/kg/min IV infusion, titrate to aPTT 1.5-3x baseline value
Myocardial infarction: 100 mcg/kg IV bolus + 1-3mcg/kg/min IV infusion x 6-72 hours; goal aPTT 50-85 seconds
Cerebral thrombosis: 60 mg/day continuous IV infusion x 2 days, then 10mg IV BID x 5 days
Coronary thrombosis prophylaxis after PCI (in patients at risk for HIT): 350 mcg/kg IV bolus + 25 mcg/kg/min IV continuous infusion; titrate to maintain activated clotting time 300-450 seconds
Argatroban
Rivaroxaban
Apixaban
Enoxaparin
Bivalirudin
Tenecteplase
Alteplase
Unfractionated heparin