Dexamethasone 10mg IV q12hrs
Most important therapy, with possible dramatic and rapid resolution of symptoms
Continue treatment until complete disappearance of signs and symptoms
Temporary discharge ATRA or ATO only in severe cases of DS (renal failure or ICU admit)
Supportive
Mechanical ventilation for respiratory failure
Careful IVF admin, prioritizing blood products for coagulopathies (DIC)
Furosemide for fluid overload
CRRT/HD for refractory renal failure
Vasopressors
Empiric antibiotics
Avoid invasive pleural/pericardial effusion diagnostics
Most important therapy, with possible dramatic and rapid resolution of symptoms
Continue treatment until complete disappearance of signs and symptoms
Mechanical ventilation for respiratory failure
Careful IVF admin, prioritizing blood products for coagulopathies (DIC)
Furosemide for fluid overload
CRRT/HD for refractory renal failure
Vasopressors
Empiric antibiotics
Avoid invasive pleural/pericardial effusion diagnostics
Retinoic acid syndrome
Sepsis
Down syndrome
Fungal infection
Grey baby syndrome
Pulmonary hemorrhage
DiGeorge syndrome
Pneumonia