Options
Irradiated: for very immunosuppressed (to prevent graft vs host)
Leukocyte-reduced: for patients likely to receive multiple RBC or platelets in future
CMV seronegative: for <1yr old, if might need bone marrow transplant in future
Anemia
10 cc/kg of pRBCs raises hemoglobin by 3 gm/dL
Raise hemoglobin to >8
Thrombocytopenia
0.1 unit/kg platelets results in 30-50K increase in platelet count
Risk of spontaneous ICH is extremely low until platelets <5K
Transfuse if:
Asymptomatic with platelets <10K
Invasive procedures require platelets >50K
Irradiated: for very immunosuppressed (to prevent graft vs host)
Leukocyte-reduced: for patients likely to receive multiple RBC or platelets in future
CMV seronegative: for <1yr old, if might need bone marrow transplant in future
10 cc/kg of pRBCs raises hemoglobin by 3 gm/dL
Raise hemoglobin to >8
0.1 unit/kg platelets results in 30-50K increase in platelet count
Risk of spontaneous ICH is extremely low until platelets <5K
Transfuse if:
Asymptomatic with platelets <10K
Invasive procedures require platelets >50K
Asymptomatic with platelets <10K
Invasive procedures require platelets >50K
Aggressive IV hydration
Urinary alkalinization (pH 7-7.5)
Allopurinol (for Tumor Lysis Syndrome (TLS))
Avoid diuretics and pRBC transfusion (platelets ok)
Give platelets if <20K
Leukapheresis
Leukemia 
Leukemias will often involve >1 cell line; other conditions restricted to single line
Leukopenia
Aplastic anemia
Acute myeloid leukemia
Iron deficiency anemia
Myelofibrosis
Viral infection 