Bolus 100-250mL 3% NS 100cc bolus over 10min; repeat after 10min x1 if no improvement
Most studies used 250 mL bolus of 7.5%<unk>  with dextran
Initial 250mL bolus of 3% will reduce ICP and can be delivered through a peripheral line
Target Na 145-155 meq/dL
Hypertonic saline
Dextrose
Mannitol
Lacosamide
D5W
Insulin
Calcium chloride
Sodium bicarbonate