Inhibit<unk> -4, an enzyme expressed on surface of most cell types<unk> -4 deacctivates other bioactive peptides, including incretins such as glucagon-like peptide-1 (GLP-1).
GLP-1 is secreted in response to nutrients, stimulating glucose-dependent insulin release from pancreatic beta-cells, which in turn decreases blood sugar levels.
Also decreases gastric emptying and inhibits postprandial glucagon release
DPP-4 inhibitors
GLP-1 agonists
Proton-pump inhibitor
ACE inhibitor
SGLT-2 Inhibitor
Angiotensin II receptor antagonists
Calcium channel blockers
Aminoglycosides