Characterized by areas of<unk>  with excessive osteolytic activity and subsequent increased ostoblastic activity, resulting in disorganized<unk>  formation
Results in osteolytic lesions and weakened<unk> 
Eventually, affected<unk> s may be abnormally enlarged
Exact etiology unknown, likely genetic component
Prevalence increases with age, more common in people of European descent
Paget's disease of bone
Bone tumor 
Ewing sarcoma
Multiple myeloma, myelofibrosis
Osteogenesis imperfecta
Fibrous dysplasia
Myositis ossificans
Intramedullary osteosclerosis