Clinical diagnosis with electrophysiological studies
3 separate criteria can be used to diagnose CIPD
Only the American Academy of Neurology requires a lumbar puncture and nerve-biopsy specimen
Closest differential is Guillain-Barre syndrome
The onset of GBS is usually easily identified, while the precise onset of<unk>  is typically less clear
Antecedent events are more frequent with GBS than in<unk> 
~70% of GBS cases are preceded by an infectious illness, vaccination, or surgery by three to four weeks prior to the onset of clinical symptoms.
By contrast, most studies have found an antecedent event prior to<unk>  in no more than 30% of patients.
Prominent sensory signs (ie, sensory ataxia and impaired vibration and pinprick sensation) favor<unk> 
The need for ventilator support favors GBS
Autonomic dysfunction (tachycardia, urinary retention) much more common in GBS than CIPD
Progression or relapse beyond eight weeks from onset suggests acute-onset<unk>  rather than GBS
May be difficult to distinguish initially between CIPD and GBS if recognized early but relapsing-remitting course over months with identify CIPD
Only the American Academy of Neurology requires a lumbar puncture and nerve-biopsy specimen
The onset of GBS is usually easily identified, while the precise onset of<unk>  is typically less clear
Antecedent events are more frequent with GBS than in<unk> 
~70% of GBS cases are preceded by an infectious illness, vaccination, or surgery by three to four weeks prior to the onset of clinical symptoms.
By contrast, most studies have found an antecedent event prior to<unk>  in no more than 30% of patients.
Prominent sensory signs (ie, sensory ataxia and impaired vibration and pinprick sensation) favor<unk> 
The need for ventilator support favors GBS
Autonomic dysfunction (tachycardia, urinary retention) much more common in GBS than CIPD
Progression or relapse beyond eight weeks from onset suggests acute-onset<unk>  rather than GBS
May be difficult to distinguish initially between CIPD and GBS if recognized early but relapsing-remitting course over months with identify CIPD
Lumbar puncture can be performed inpatient
Will show elevated protein without pleocytosis
Nerve biopsy will show demyelination and demyelination often with signs of inflammation
Often unnecessary and of low yield due to proximal nerve involvement, but still performed if diagnosis uncertain
MRI may show gadolinium enhancement and enlargement of proximal nerves or roots
Electrophysiological diagnostic procedures with show evidence of demyelination
Will show elevated protein without pleocytosis
Often unnecessary and of low yield due to proximal nerve involvement, but still performed if diagnosis uncertain
Chronic inflammatory demyelinating polyneuropathy
Neuromuscular weakness
Diabetic peripheral neuropathy
Upper motor neuron:
Acute flaccid myelitis
CVA
Long thoracic neuropathy
Hemorrhagic stroke