Classic triad: anemia, jaundice, splenomegaly
No anemia, normal retic count, little or no jaundice/splenomegaly
No RBC transfusions
Dx’d later in life
Anemic, elevated retic, elevated bili, maybe splenomegaly
May require RBC transfusions
Dx’d in infancy or early childhood
Marked hemolysis, anemia, hyperbilirubinemia, splenomegaly
Require regular RBC transfusions
Dx’d in infancy
Hereditary spherocytosis
Disseminated Intravascular Coagulation 
Paroxysmal nocturnal hemoglobinuria
Thrombotic Thrombocytopenic Purpura 
Myelophthistic anemia
Hemolytic Uremic Syndrome 
Thalassemia
HELLP syndrome