Serotonergic agent plus 1 of the following:
Spontaneous clonus
Inducible clonus AND (agitation or diaphoresis)
Ocular Clonus AND (agitation or diaphoresis)
Tremor AND hyperreflexia
Hypertonia AND temperature >38 AND (ocular clonus or inducible clonus)
84% Sn, 97% Sp
History of a new serotonergic drug or a dose increase of a serotonergic drug are helpful<unk>  is usually much more acute in onset than NMS which may develop over days or weeks
Presence of ‘lead pipe’ rigidity is typical of NMS, while<unk>  typically manifests with tremor and hyperreflexia
Elevations in CK, LFTs, and WBC, coupled with a low iron level, distinguishes NMS from<unk>  among patients taking both neuroleptic and<unk>  agonist medications simultaneously
Serotonin syndrome
Chorea
Cannabinoid hyperemesis syndrome
Sydenham's chorea
Cholinergic crisis
Neuroleptic malignant syndrome
Cocaine toxicity
Anticholinergic toxicity