A type III hypersensitivity reaction (secondary to injection of anitoxins e.g. tetanus, rabies)
Reactions secondary to the administration of nonprotein drugs (e.g. Amoxicillin, cefaclor, cephalexin (Keflex), trimethoprim-sulfamethoxazole)
Primary occurs 6-21 days after initial exposure
1-4 days after subsequent exposures to the same antigen
Symptoms usually last 1-2 weeks before spontaneously subsiding
Long-lasting sequelae generally do not occur
Fatalities are rare and usually are due to continued administration of the antigen
1-4 days after subsequent exposures to the same antigen
Serum sickness
Erythema multiforme
Rabies
Mononucleosis
Infectious mononucleosis
Polymyositis
Metal fume fever
Systemic Lupus Erythematosus