Activated charcoal PO x 1
Consider gastric lavage, if can be performed <1 hour after ingestion
Hypertension
Treat only with short-acting agents: may develop precipitous hypotension
Phentolamine: 2.5-5mg IV bolus q15-15min; can also give as infusion 0.2-0.5mg/min
Nitroprusside: 1mcg/kg/min and titrate up
Hypotension: intravenous fluid +/- norepinephrine
CNS excitation and Seizures: benzodiazepines are 1st line
Hyperthermia
Routine cooling measures
Consider paralysis if patient has persistent muscle rigidity
Treat only with short-acting agents: may develop precipitous hypotension
Phentolamine: 2.5-5mg IV bolus q15-15min; can also give as infusion 0.2-0.5mg/min
Nitroprusside: 1mcg/kg/min and titrate up
Routine cooling measures
Consider paralysis if patient has persistent muscle rigidity
Monoamine oxidase inhibitor toxicity
Intoxications
Synthetic cathinone toxicity
Amphetamines
Tricyclic antidepressant toxicity
Antimuscarinics
Mescaline toxicity
Methylxanthine toxicity 