Trend:
Volume status
Urine pH
Chemistry
CK
Calcium, phosphorus
LFTs (elevation will resolve with resolving<unk> 
Start with IVF 1-2 L/hr
After rapid correction of fluid deficit, one method is infusing 2.5 mL/kg/hr with urine output goal of 200-300 ml/hr (2-3 cc/kg/hr)
Frequently need ~10 L/day
Administered as bicarbonate drip
Mix 150 mL [3 amps] of 8.4% sodium bicarbonate with 1 L D5W
Infuse at 200 mL/hour; rate is adjusted to achieve urine pH of >6.5
Controversial; no RCT to date have demonstrated benefit
Consider if CK >5000, severe muscle injury (crush injury), rising CK AND urine pH <6.5
Contraindications:
Severe hypocalcemia
Arterial pH > 7.50
Serum bicarbonate > 30 meq/L
Arterial pH and serum calcium should be monitored q2hr
Discontinue alkalinization:
Urine pH does not rise above 6.5 after 3-4hr
Patient develops symptomatic hypocalcemia
Arterial pH > 7.5
Serum bicarbonate >30 meq/L
Mix 150 mL [3 amps] of 8.4% sodium bicarbonate with 1 L D5W
Infuse at 200 mL/hour; rate is adjusted to achieve urine pH of >6.5
Severe hypocalcemia
Arterial pH > 7.50
Serum bicarbonate > 30 meq/L
Arterial pH and serum calcium should be monitored q2hr
Urine pH does not rise above 6.5 after 3-4hr
Patient develops symptomatic hypocalcemia
Arterial pH > 7.5
Serum bicarbonate >30 meq/L
Mannitol administration can worsen dehydration and oliguria and although used in the past should generally be avoided
No RCT to date has demonstrated benefit
Use rocuronium due to the potential elevations in potassium that result from the<unk>
Rhabdomyolysis
Compartment syndrome
Diabetic ketoacidosis 
Contusion
Diabetic ketoacidosis
Crush syndrome
Tumor lysis syndrome
Degloving injury