Stomatotoxic effect begins approximately 7 days after therapy
Erythema of the soft tissue of buccal mucosa or soft palate and burning sensation in mouth->elevated, white desquamative patches->epithelial sloughing leading to shallow ulcerations with pseudomembranous look->coalesce into large, painful ulcerations
Erythema and ulcerations of the mucosal lining of the gastrointestinal tract
Causes dysphagia, changes in taste, secondary infections, weight loss
Oral<unk>  is associated with increased inpatient hospitalization duration, bacteremia and higher 100‐day mortality.
GI<unk>  is associated with nausea/vomiting, bloating, diarrhea, intestinal cramping and anal pain.
Oral<unk>  is associated with increased inpatient hospitalization duration, bacteremia and higher 100‐day mortality.
GI<unk>  is associated with nausea/vomiting, bloating, diarrhea, intestinal cramping and anal pain.
Mucositis
Oral candidiasis
Myositis 
Herpes simplex virus infection
Dermatitis
Acute graft-versus-host disease
Alopecia
Conjunctivitis 