Monroe-Kellie hypothesis
Volume of<unk>  space is constant
3 components
Brain Tissue (80%)
Blood (10% or 150mL)
CSF (10% or 150 mL)
Increase in one of the components → reduction of other two →must maintain a fixed total<unk>  volume.
CSF is created at a rate of 20mL/hr or 500mL/day.
Neuronal injury occurs secondary to vascular compromise to brain cells either by a reduction in cerebral blood flow or direct ischemia. This is an  emergency  and requires emergent intervention if sustained > 5-10 minutes
Volume of<unk>  space is constant
3 components
Brain Tissue (80%)
Blood (10% or 150mL)
CSF (10% or 150 mL)
Increase in one of the components → reduction of other two →must maintain a fixed total<unk>  volume.
Brain Tissue (80%)
Blood (10% or 150mL)
CSF (10% or 150 mL)
Elevated intracranial pressure
Intracranial hemorrhage
Ventriculoperitoneal shunt obstruction
Intra-axial
Post-lumbar puncture headache
Hemorrhagic stroke 
Ventriculoperitoneal shunt overdrainage
Traumatic intracerebral hemorrhage