O2
Titrate to pulse oximetry >92%
Incentive Spirometer
Hydration
Oral hydration preferred
IV hydration with hypotonic fluid if patient unable to tolerate PO
Analgesia
Pulmonary toilet is important but avoid excessive sedation
Bronchodilators
Antibiotics
3rd generation cephalosporin + macrolide
Transfusion (leucocyte depleted)
Consider transfusion to goal of hemoglobin 11 / hematocrit 30 for:
O2 Sat <92% on room air
hematocrit 10-20% below patient's usual hematocrit or dropping hematocrit
Exchange transfusion
Consider for:
Progression of<unk>  despite simple transfusion
Severe hypoxemia
Multi-lobar disease
Previous history of severe<unk>  or cardiopulmonary disease
Titrate to pulse oximetry >92%
Oral hydration preferred
IV hydration with hypotonic fluid if patient unable to tolerate PO
Pulmonary toilet is important but avoid excessive sedation
3rd generation cephalosporin + macrolide
Consider transfusion to goal of hemoglobin 11 / hematocrit 30 for:
O2 Sat <92% on room air
hematocrit 10-20% below patient's usual hematocrit or dropping hematocrit
O2 Sat <92% on room air
hematocrit 10-20% below patient's usual hematocrit or dropping hematocrit
Consider for:
Progression of<unk>  despite simple transfusion
Severe hypoxemia
Multi-lobar disease
Previous history of severe<unk>  or cardiopulmonary disease
Progression of<unk>  despite simple transfusion
Severe hypoxemia
Multi-lobar disease
Previous history of severe<unk>  or cardiopulmonary disease
Acute chest syndrome
Pneumonia
Acute coronary syndrome 
Asthma
Flail chest
Pulmonary hypertension
Fat embolism syndrome
Vaso-occlusive pain crisis