INR is a poor marker of coagulation in cirrhosis
Risk of post-procedure bleeding for minimally invasive<unk>  ~20% in cirrhotics
Each 100 cc infusion of plasma increases portal venous pressure by 1 mmHg (normal pressure 5-10 mmHg)
Correction of elevated INR in cirrhosis leads to unnecessary volume expansion
PT/INR only measures the procoagulant pathway and does not detect anticoagulant pathway (protein C and S, antithrombin)
Thus, cirrhotic<unk>  may be hypercoagulable despite high INR due to natural anticoagulant deficiencies
Do not use PT/INR to risk stratify liver disease<unk> 
Rather use target platelet count with goal > 50,000 uL and fibrinogen level > 120 mg/dL
PT/INR only measures the procoagulant pathway and does not detect anticoagulant pathway (protein C and S, antithrombin)
Thus, cirrhotic<unk>  may be hypercoagulable despite high INR due to natural anticoagulant deficiencies
Do not use PT/INR to risk stratify liver disease<unk> 
Rather use target platelet count with goal > 50,000 uL and fibrinogen level > 120 mg/dL
Procedures in patients with coagulopathies
Immunocompromised antibiotics
Pregnancy and lactation drug labeling
Conducted energy device
Bioterrorism antibiotics
Safety at sea
Environmental exposure antibiotics
Healthcare occupational exposure to blood or other body fluids