Pregnancy Rating: D; Avoid use (Risk of maternal hemorrhage and embryo-fetal death up to 49xMRHD based on animal data and risk of maternal/fetal bleeding base don mechanism of action; No known risk of teratogenicity)
Lactation risk: L3; Safety unknown
Adult:
Thromboembolism/stroke Prophylaxis
CrCl > 95: Avoid Use
CrCl 50-95: No Adjustment
CrCl 15-50: 30 mg QD
CrCl <15 (not on HD): Avoid use
DVT/PE treatment
CrCl 15-30: 30 mg QD
Cr Cl <15 (not on HD): Avoid use
Pediatric: N/A
Thromboembolism/stroke Prophylaxis
CrCl > 95: Avoid Use
CrCl 50-95: No Adjustment
CrCl 15-50: 30 mg QD
CrCl <15 (not on HD): Avoid use
DVT/PE treatment
CrCl 15-30: 30 mg QD
Cr Cl <15 (not on HD): Avoid use
CrCl > 95: Avoid Use
CrCl 50-95: No Adjustment
CrCl 15-50: 30 mg QD
CrCl <15 (not on HD): Avoid use
CrCl 15-30: 30 mg QD
Cr Cl <15 (not on HD): Avoid use
Adult: Child-Pugh Class B or C: Avoid use
Pediatric: N/A
Edoxaban
Clopidogrel
Rivaroxaban
Apixaban
Enoxaparin
Warfarin
Ticagrelor
Ticlopidine