In 2014, ~2.2million human exposures reported to US poison control centers
Top 5 substance classes:
analgesics (11%)
cosmetics/personal care products (8%)
household cleaning substances (8%)
sedatives/hypnotics/antipsychotics (6%)
antidepressants (4%)
1,835 human exposures resulted in death
analgesics (11%)
cosmetics/personal care products (8%)
household cleaning substances (8%)
sedatives/hypnotics/antipsychotics (6%)
antidepressants (4%)
Parasympathetic - ACh is transm
Muscarinic
receptors in heart, eye, lung, GI, skin and sweat glands
Bradycardia
Miosis
Bronchorrhea / Bronchospasm
Hyperperistalsis (SLUDGE)
Sweating
Vasodilation
Nicotinic
receptors in both sympathetic and parasympathetic nervous systems
fasciculations, flaccid paralysis
?Mild bradycardia, hypotension
Sympathetic
Alpha effects (vessels, eye, skin)
Mydriasis, hypertension, sweating
Beta effects (heart, lungs)
Tachycardia, bronchodilation
Muscarinic
receptors in heart, eye, lung, GI, skin and sweat glands
Bradycardia
Miosis
Bronchorrhea / Bronchospasm
Hyperperistalsis (SLUDGE)
Sweating
Vasodilation
Nicotinic
receptors in both sympathetic and parasympathetic nervous systems
fasciculations, flaccid paralysis
?Mild bradycardia, hypotension
receptors in heart, eye, lung, GI, skin and sweat glands
Bradycardia
Miosis
Bronchorrhea / Bronchospasm
Hyperperistalsis (SLUDGE)
Sweating
Vasodilation
receptors in both sympathetic and parasympathetic nervous systems
fasciculations, flaccid paralysis
?Mild bradycardia, hypotension
Alpha effects (vessels, eye, skin)
Mydriasis, hypertension, sweating
Beta effects (heart, lungs)
Tachycardia, bronchodilation
Mydriasis, hypertension, sweating
Tachycardia, bronchodilation
Toxicology 
Altered Metabolism
Dermatologic nomenclature
Aspirin 
Aria Health 
Withdrawal states 
Sign out tools
Thyroid hormones