Na Channel Blockade (2-6 hours post ingestion)
Negative inotropy, heart block, hypotension, ectopy
Antihistamine Effects
Sedation, coma
Antimuscarinic Effects (early toxicity, within 2 hours)
Central
Agitation, delirium, confusion, hallucinations
Slurred speech, ataxia
Sedation, coma
Seizures
Peripheral
Mydriasis, decreased secretions, dry skin, ileus, urinary retention
Tachycardia, hyperthermia, hypertension
α1 Receptor Blockade
Sedation, orthostatic hypotension, miosis
Inhibition of amine reuptake
Sympathomimetic effects
Myoclonus, hyperreflexia
Serotonin Syndrome (only when used in combination with other serotonergic agents)
Antagonism at GABA A receptors
Seizures
Negative inotropy, heart block, hypotension, ectopy
Sedation, coma
Central
Agitation, delirium, confusion, hallucinations
Slurred speech, ataxia
Sedation, coma
Seizures
Peripheral
Mydriasis, decreased secretions, dry skin, ileus, urinary retention
Tachycardia, hyperthermia, hypertension
Agitation, delirium, confusion, hallucinations
Slurred speech, ataxia
Sedation, coma
Seizures
Mydriasis, decreased secretions, dry skin, ileus, urinary retention
Tachycardia, hyperthermia, hypertension
Sedation, orthostatic hypotension, miosis
Sympathomimetic effects
Myoclonus, hyperreflexia
Serotonin Syndrome (only when used in combination with other serotonergic agents)
Seizures
Tricyclic antidepressant toxicity
Medications[1]
Antipsychotic toxicity
Atropine
Clonidine toxicity
Lomotil toxicity
Benzodiazepine toxicity
Antihistamines