Most patients begin to be symptomatic at ~7gm/dL
Weakness, fatigue, lethargy, dyspnea on exertion, palpitations
Skin, nail bed, mucosal pallor
Widened pulse pressure
Jaundice, hepatosplenomegaly (hemolysis)
Peripheral neuropathy (B12 deficiency)
Anemia
Hemorrhage
Pancytopenia
Hereditary
Leukopenia
Acquired
Polycythemia
Microangiopathic Hemolytic Anemia 