TB- worsening TB symptoms
MAC- localized lymphadenitis, pulmonary disease, systemic inflammation indistinguishable from active MAC
MAC-IRIS patients are not bacteremic
Cryptococcosis- worsening meningitis symptoms
CMV- retinitis, vitritis, uveitis<unk>  due to CMV can cause vision loss
mean time to vitritis 20 weeks
Hepatitis B or C- transient transaminitis difficult to distinguish from drug induced cause
hepatic flares usually mild, may decompensate cirrhotics.
Progressive multifocal leukoencephalopathy- worsening focal neuro lesions, changes on MRI
Kaposi's Sarcoma- worsening Kaposi's
Autoimmune diseases- Pre-existing autoimmune disorder exacerbation
MAC-IRIS patients are not bacteremic<unk>  due to CMV can cause vision loss
mean time to vitritis 20 weeks
mean time to vitritis 20 weeks
hepatic flares usually mild, may decompensate cirrhotics.
Herpes Simplex Virus and Varicella zoster virus reactivation
Non-specific derm- many including oral and genital warts
Immune reconstitution inflammatory syndrome
New infection not associated with IRIS 
Immune reconstitution syndrome
Opportunistic infection
Cytokine release syndrome
HIV neurologic complications
Drug rash with eosinophilia and systemic symptoms syndrome
Toxoplasmosis