Workup should be targeted toward specific diagnosis.
In non-auditory<unk> , assume organic pathology until proven otherwise.
New diagnosis of psychiatric disease as cause of<unk>  should generally not be made in ED without first ruling out organic pathology
If concern for suicidal or unknown toxic ingestion:
Acetaminophen level
Salicylate level
ECG
Acetaminophen level
Salicylate level
ECG
Hallucinations
Serotonin-Like Agents
Extrapyramidal reaction
Lysergic acid diethylamide 
Ergotism
Psilocybin 
Dysphonia
N,N-Dimethyltryptamine 