Also known as<unk>  (PEP)
Probability of<unk>  transmission from a percutaneous needle stick is approximately 0.3% (1 in 300) and 0.09% from mucous membrane<unk> .
~79% transmission reduction
Common side-effects = constitutional, gastrointestinal
Initiate ASAP (goal = <2 hours after<unk> 
Initiate if <72 hours since<unk> 
PEP is likely to be less effective when started more than 72 hours after<unk> , but the interval after which no benefit is gained from PEP for humans is undefined.
If initiation is delayed, the likelihood increases that benefits might not outweigh the risks inherent in taking antiretroviral medications.
From 2013 recommendations 
PEP is recommended when occupational<unk> s to<unk>  occur
PEP medication regimens should be started as soon as possible after occupational<unk>  to<unk> , and continued for 28 days
New recommendation - PEP medication regimens should contain 3 (or more) antiretroviral drugs for all occupational<unk> s to<unk> 
New recommendation - if a newer fourth-generation combination<unk>  p24 antigen-HIV antibody test is utilized for follow-up<unk>  testing of exposed HCP,<unk>  testing may be concluded 4 months after<unk> ; if a newer testing platform is not available, follow-up<unk>  testing is typically concluded 6 months after an<unk><unk> .
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HIV post-exposure prophylaxis
Ritonavir-boosted nirmatrelvir
COVID-19 Vaccine 
Ritonavir
Molnupiravir
Abacavir/lamivudine
Isolation precautions
Emtricitabine/tenofovir