Clinical syndromes produced by T. brucei gambiense and T. brucei rhodesiense are similar in nature, however the rhodesience strain is much more rapidly progressive and can present with fulminant disease over the course of a few months, not years like the gambiense strain
May present differently in travelers
Known as the hemolymphatic stage
Chancre
May be earliest sign
Painless, well circumscribed, rubbery lesion.  (More common with rhodesiense sp.)
Winterbottom's sign
Lymphadenopathy of posterior cervical lymph nodes-characteristic but not always present
Intermittent symptoms corresponding to waves of parasitemia
Fever, headache, malaise, arthralgias, rash, pruritus
May be earliest sign
Painless, well circumscribed, rubbery lesion.  (More common with rhodesiense sp.)
Lymphadenopathy of posterior cervical lymph nodes-characteristic but not always present
Fever, headache, malaise, arthralgias, rash, pruritus
100% fatal if untreated
Involvement of the CNS
Progressive meningoencephalitis
Brain edema
Cerebral microhemorrhages
Multifocal white matter demyelination
Mott cells in CSF
Activated plasma cells with IgM inclusions
Neurologic symptoms
Headache, personality changes, inability to concentrate, difficulty with complex mental tasks, psychosis, ataxia, alteration of wake/sleep cycles, parkinsonian like movements
Eventually progresses to the point where the patient is stuporous and/or in a comatose state
Progressive meningoencephalitis
Brain edema
Cerebral microhemorrhages
Multifocal white matter demyelination
Mott cells in CSF
Activated plasma cells with IgM inclusions
Neurologic symptoms
Headache, personality changes, inability to concentrate, difficulty with complex mental tasks, psychosis, ataxia, alteration of wake/sleep cycles, parkinsonian like movements
Eventually progresses to the point where the patient is stuporous and/or in a comatose state
Activated plasma cells with IgM inclusions
Headache, personality changes, inability to concentrate, difficulty with complex mental tasks, psychosis, ataxia, alteration of wake/sleep cycles, parkinsonian like movements
Eventually progresses to the point where the patient is stuporous and/or in a comatose state
Human african trypansomiasis 
Infectious
Babesiosis
Sepsis
African trypanosomiasis
Meningitis
Leishmaniasis
Encephalitis