adults in the Netherlands
Median age 65
Median NIHSS 17 in interventional cohort, 18 in control
Adults with acute ischemic stroke presenting under 6 hours in the Netherlands
18 years or older
Acute ischemic stroke presenting within 6 hours of onset
NIHSS 2+
confirmed large vessel occlusion - ICA, M1 or M2
Infarction in territory of occluded artery in past 6 weeks
Plts <40k, INR >3, aPTT > 50
MR CLEAN
PALS 
Ultrasound: Pelvic
Hemocue
NEXUS cervical spine rule
Ultrasound: Tendons
ADDIE system
AVPU scale