Marrow infiltration (tumor or infection)
Viral infections (rubella, HIV)
Marrow suppression (commonly chemotherapy or radiation)
Congenital thrombocytopenia
Fanconi anemia
Alport syndrome
Bernand Soulier
Vitamin B12 and/or folate deficiency
Fanconi anemia
Alport syndrome
Bernand Soulier
Idiopathic thrombocytopenic purpura
Thrombotic Thrombocytopenic Purpura (TTP)
Hemolytic Uremic Syndrome (HUS)
Disseminated Intravascular Coagulation (DIC)
Viral infections (HIV, mumps, varicella, EBV)
Drugs (heparin, protamine)
Postransfusion or Posttransplantation
Autoimmune destruction (SLE or Sarcoidosis)
Mechanical destruction
Artificial valves
ECMO
HELLP syndrome
Excessive hemorrhage
Hemodialysis, extracorporeal circulation
Splenic Sequestration
Occurs in Sickle cell disease and Cirrhosis
Artificial valves
ECMO
Occurs in Sickle cell disease and Cirrhosis
sulfa antibiotics, ETOH, ASA, thiazide diuretics/furosemide
ITP in Pregnancy
Marrow infiltration 
Inborn errors of metabolism
Viral infections 
Trauma in pregnancy
Marrow suppression 
Acute fatty liver of pregnancy
Congenital thrombocytopenia