Fever
Toxic appearance
Hypotension
Mucosal lesions
Severe pain
Very old or young age
Immunosuppressed
New medication
Fever and rash
Nausea and vomiting 
Nausea and vomiting
Acute fever
Leukostasis and hyperleukocytosis
Neutropenic fever
Erythematous rash
Abdominal pain 