Malaise, anorexia, myalgias, arthralgias, fever, painful skin, GI symptoms
Extracutaneous manifestations may persist for 1-2 weeks following skin symptoms
Exam with warm<unk> der erythema with overlying flaccid bullae, erosions with exfoliation
Positive Nikolsky's sign (able to rub off superficial layers of skin with pressure)
Mucosal involvement (oral, conjunctival, respiratory, GU)
Systemic toxicity
25-35% Mortality
Death is usually caused by infection, hypovolemia, and electrolyte disorders
Predictors of poor prognosis include: age, extent of disease, leukopenia, azotemia, and thrombocytopenia
Death is usually caused by infection, hypovolemia, and electrolyte disorders
Toxic epidermal necrolysis
Toxic infectious erythemas
Contact dermatitis
Exfoliative drug eruptions
Bullosis diabeticorum
Primary blistering disorders
Dermatitis herpetiformis
Stevens-Johnsons syndrome