Incubation period 3-30 days
Stage 1 (Primary): Self-limited painless genital papule/ulcer (lasts ~2-3 days)
Seen on coronal sulcus in men, posterior vaginal fourchette in women
Can also occur in rectum (hemorrhagic proctitis), urethra, vagina
Stage 2 (Secondary): Painful inguinal and/or femoral lymphadenopathy (2-6 weeks after primary lesion)
Lymph nodes become necrotic → suppurative → formation of buboes
Fluctuant lymph nodes classically form a "groove sign" when adenopathy extends above and below the inguinal ligament
Systemic symptoms: fever, myalgia, malaise
Occasionally - arthritis, ocular, cardiac, pulmonary, aseptic meningitis, hepatitis
Stage 3 (Tertiary): Proctocolitis, anorectal syndrome
Usually manifests in women or men who have sex with men
Rectal pain, discharge, bleeding
Can also → fistula, abscess, strictures, megacolon
Seen on coronal sulcus in men, posterior vaginal fourchette in women
Can also occur in rectum (hemorrhagic proctitis), urethra, vagina
Lymph nodes become necrotic → suppurative → formation of buboes
Fluctuant lymph nodes classically form a "groove sign" when adenopathy extends above and below the inguinal ligament
Systemic symptoms: fever, myalgia, malaise
Occasionally - arthritis, ocular, cardiac, pulmonary, aseptic meningitis, hepatitis
Fluctuant lymph nodes classically form a "groove sign" when adenopathy extends above and below the inguinal ligament
Occasionally - arthritis, ocular, cardiac, pulmonary, aseptic meningitis, hepatitis
Usually manifests in women or men who have sex with men
Rectal pain, discharge, bleeding
Can also → fistula, abscess, strictures, megacolon
Lymphogranuloma venereum
Chancroid
Tinea capitis
Chlamydia trachomatis
Herpetic whitlow
Granuloma inguinale
Cutaneous larva migrans
Hepatitis B