CV (only with IV form)
Bradycardia
Hypotension
Vfib
Asystole
Neuro
Nystagmus
First only with forced lateral gaze; later becomes spontaneous
May disappear at higher levels
Ataxia
Decreased LOC
GI
Nausea and vomiting
Skin
tissue infiltration (IV) → "Purple glove syndrome"
edema, pain, ischemia, tissue necrosis, compartment syndrome
Anticonvulsant hypersensitivity syndrome
Fever, eosinophilia, rash, pseudolymphoma, SLE, pancytopenia, hepatitis, pneumonitis, pharyngitis, rhabdomyolysis
Mortality rate of 10%
Bradycardia
Hypotension
Vfib
Asystole
Nystagmus
First only with forced lateral gaze; later becomes spontaneous
May disappear at higher levels
Ataxia
Decreased LOC
First only with forced lateral gaze; later becomes spontaneous
May disappear at higher levels
Nausea and vomiting
tissue infiltration (IV) → "Purple glove syndrome"
edema, pain, ischemia, tissue necrosis, compartment syndrome
Fever, eosinophilia, rash, pseudolymphoma, SLE, pancytopenia, hepatitis, pneumonitis, pharyngitis, rhabdomyolysis
Mortality rate of 10%
Phenytoin toxicity
Carbamazepine toxicity
Carbamate toxicity
Tianeptine toxicity
Valproic acid toxicity
Antipsychotic toxicity
Mescaline toxicity
Phencyclidine toxicity