Classically presents around 6 to 18 months of age when foods containing gluten are introduced but can occur anytime
Chronic diarrhea
Weight loss
Abdominal distension
Iron deficiency with or without anemia
Aphthous stomatitis
Short stature
High aminotransferase levels
Chronic fatigue
Reduced bone mineral density
Few or no gastrointestinal symptoms
Older children or adults
Dermatitis herpetiformis
Gluten Ataxia
Patients have no symptoms
Diagnosed based on serology of histology
Found in patients with strong family history of disease, autoimmune disorders, chromosomal disorders (Down syndrome)
Persistent or recurrent symptoms or villous atrophy despite gluten free diet for 12 months
Life threatening
Often observed after a general immune stimulus such as surgery or infection
Mostly observed in children
Severe diarrhea
Hypoproteinemia
Metabolic and electrolyte disturbances
Osteoporosis
Impaired splenic function
Infertility
Recurrent abortion
Ulcerative jejunoileitis
Enteropathy-associated intestinal T-cell lymphoma
Adenocarcinoma of the jejunum
Non-Hodgkin lymphoma
Vitamin deficiencies
Celiac disease
Acute diarrhea
Crohn's disease
Chronic diarrhea
Gastroesophageal reflux disease
Irritable bowel syndrome
Small intestinal bacterial overgrowth
Post-infectious irritable bowel syndrome