Triad of:
Fever
Pharyngitis
Lymphadenopathy
Symptoms
Abrupt or insidious
Headache, fever, and malaise common, sore throat and lymphadenopathy follow
Rash in 10-15% usually between 4th-6th day of illness
Red macular or maculopapular morbilliform rash of trunk & upper arms
Occasionally involves face, thigh and legs, periorbital & eyelid edema in 50% of cases
Previously treated as strep pharyngitis
Morbilliform rash can develop
95% of patients on amoxicillin or ampicillin
40-60% with other beta-lactams
Illness typically 2-4 weeks, but malaise and fatigue may last for months
Fever
Pharyngitis
Lymphadenopathy
Abrupt or insidious
Headache, fever, and malaise common, sore throat and lymphadenopathy follow
Rash in 10-15% usually between 4th-6th day of illness
Red macular or maculopapular morbilliform rash of trunk & upper arms
Occasionally involves face, thigh and legs, periorbital & eyelid edema in 50% of cases
Red macular or maculopapular morbilliform rash of trunk & upper arms
Occasionally involves face, thigh and legs, periorbital & eyelid edema in 50% of cases
Morbilliform rash can develop
95% of patients on amoxicillin or ampicillin
40-60% with other beta-lactams
95% of patients on amoxicillin or ampicillin
40-60% with other beta-lactams
Infectious mononucleosis
Streptococcal pharyngitis 
Typhoid fever
Neisseria gonorrhoeae
AIDS fever of unknown origin
Diphtheria 
Ebola virus disease
Bacterial Tracheitis