Direct visualization of the trypanosomes (Gold Standard)
Blood smears with either Giemsa or Wright's stain
Samples can include CSF, blood, lymph node aspirates, and chancre aspirates
Must examine CSF to staging and treatment purposes
Low levels of parasitemia may require concentration of sample
Serologic testing
Card agglutination test for<unk>  (CATT)
Agglutination of freeze dried trypanosomes
Useful for epidemiologic studies
CSF analysis
Pleocytosis
Elevated protein levels
Mott cells
Direct visualization of trypanosome
Imaging
MRI - hyperintense signals in periventricular white matter
EEG - Delta waves
Blood smears with either Giemsa or Wright's stain
Samples can include CSF, blood, lymph node aspirates, and chancre aspirates
Must examine CSF to staging and treatment purposes
Low levels of parasitemia may require concentration of sample
Must examine CSF to staging and treatment purposes
Card agglutination test for<unk>  (CATT)
Agglutination of freeze dried trypanosomes
Useful for epidemiologic studies
Agglutination of freeze dried trypanosomes
Pleocytosis
Elevated protein levels
Mott cells
Direct visualization of trypanosome
MRI - hyperintense signals in periventricular white matter
EEG - Delta waves
Human african trypansomiasis 
Infectious
Babesiosis
Sepsis
African trypanosomiasis
Meningitis
Leishmaniasis
Encephalitis