Spontaneous closure common
If significant respiratory distress or impaired oxygen delivery, therapy usually required
IV indomethacin: usually effective when administered in the first 10-14 days of life.
<48 hour old: start 0.2mg/kg IV x 1, then 0.1mg/kg q12-24h x 2
2-7 days old: Start 0.2mg/kg IV x 1, then 0.2mg/kg q12-24h x 2
> 7 days old: Start 0.2mg/kg IV x 1, then 0.25mg/kg q12-24h x 2
<48 hour old: start 0.2mg/kg IV x 1, then 0.1mg/kg q12-24h x 2
2-7 days old: Start 0.2mg/kg IV x 1, then 0.2mg/kg q12-24h x 2
> 7 days old: Start 0.2mg/kg IV x 1, then 0.25mg/kg q12-24h x 2
Offered if medical therapy fails
Cardiac catheterization and catheter closure
Surgical ligation
Cardiac catheterization and catheter closure
Surgical ligation
Patent ductus arteriosus
Acute pericarditis
Ebstein anomaly
Aortopulmonary Septal Defect
Tricuspid atresia
Coarctation of the Aorta
Atrial septal defect
Coronary artery fistula