If time permits, obtain initial platelet function assay for aspirin and clopidogrel
Reversal with combination of platelet transfusion, desmopressin
Limited evidence to support mortality improvement in reversal, but little evidence of harm
Volume
At least 5 units of platelets initially to reverse routine<unk> platelet doses
Consider significantly more platelets for those who were loaded with clopidogrel within the last week
At least 5 units of platelets initially to reverse routine<unk> platelet doses
Consider significantly more platelets for those who were loaded with clopidogrel within the last week
0.3 mcg/kg/dose in 50 cc NS over 30 min
Quick onset of action, within 1 hr
Similar MOA to cryoprecipitate (increase factor VIII, vWF)
No transfusion complications of cryoprecipitate
However, effects only last up to 24 hrs, and tachyphylaxis limits efficacy repeated doses
Quick onset of action, within 1 hr
Similar MOA to cryoprecipitate (increase factor VIII, vWF)
No transfusion complications of cryoprecipitate
However, effects only last up to 24 hrs, and tachyphylaxis limits efficacy repeated doses
Anti-platelet agent reversal
Warfarin reversal
Dabigatran reversal
Rivaroxaban reversal
Unfractionated heparin reversal
Anticoagulants
Antiplatelet medications
Thrombolytics