First choice in adults: Corticosteroids
Prednisone 60-100mg/d with taper after count reaches normal (50-75% remission rate by 3 wks)
Methylprednisolone 30mg/kg/d IV x 3 days (for life-threatening bleeding)
First choice in children: Intravenous<unk> globulin G (IVIG) 1gm/kg/d x 2 days
High dose Anti-D (RhoGAM): patient must be Rh+ for it to work
Causes shift towards splenic destruction of antibody-coated Rh+ RBCs
Thereby has less functional capacity to destroy platelets
Dosage dependent on Hb level in mg/dL
Hb>10, 250 IU/kg IV x1 over 5min
Hb<10, 125 IU/kg IV x1 over 5min
Platelet transfusion
Indicated for life-threatening bleeding
Will ultimately be destroyed
Transfuse only following first dose of methylprednisolone or IVIG 
Holding transfusion until after first dose results in greater rise in platelet count
Calculate number of packs needed to increase count to over 50k (1 pack generally increases by 10k)
Estrogen for uterine bleeding: 25mg IV x1
Prednisone 60-100mg/d with taper after count reaches normal (50-75% remission rate by 3 wks)
Methylprednisolone 30mg/kg/d IV x 3 days (for life-threatening bleeding)
Causes shift towards splenic destruction of antibody-coated Rh+ RBCs
Thereby has less functional capacity to destroy platelets
Dosage dependent on Hb level in mg/dL
Hb>10, 250 IU/kg IV x1 over 5min
Hb<10, 125 IU/kg IV x1 over 5min
Hb>10, 250 IU/kg IV x1 over 5min
Hb<10, 125 IU/kg IV x1 over 5min
Indicated for life-threatening bleeding
Will ultimately be destroyed
Transfuse only following first dose of methylprednisolone or IVIG 
Holding transfusion until after first dose results in greater rise in platelet count
Calculate number of packs needed to increase count to over 50k (1 pack generally increases by 10k)
Holding transfusion until after first dose results in greater rise in platelet count
Calculate number of packs needed to increase count to over 50k (1 pack generally increases by 10k)
Platelet >30K and asymptomatic: usually do not require treatment
Platelet count <30K: prednisone
Platelet <50K AND bleeding: prednisone
Life-threatening bleeding: IVIG, methylprednisolone, platelet transfusion
Platelet count >30K: usually do not require treatment
Platelet count <20K + significant bleeding: IVIG
Platelet count <10K: IVIG
Life-threatening bleeding: IVIG, methylprednisolone, platelet transfusion
Splenectomy if above fails (only 2/3 effective)
Rho(D)<unk>  Globulin (RhoGAM)
Will induce mild hemolysis in Rh+ patients that decreases macrophage activity
Spleen will not destroy platelets covered in antibodies
Rituximab
May help as<unk>  is autoimmune process
Will induce mild hemolysis in Rh+ patients that decreases macrophage activity
Spleen will not destroy platelets covered in antibodies
May help as<unk>  is autoimmune process
Immune thrombocytopenic purpura
Marrow infiltration 
Thrombotic thrombocytopenic purpura
Viral infections 
Disseminated intravascular coagulation
Marrow suppression 
Heparin-Induced Thrombocytopenia 
Congenital thrombocytopenia