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Thrombotic Thrombocytopenic Purpura (TTP)
Hemolytic Uremic Syndrome (HUS)
HELLP syndrome
Heparin-Induced Thrombocytopenia (HIT)
Hereditary spherocytosis
Paroxysmal nocturnal hemoglobinuria (PNH)
Malignant hypertension
Scleroderma
Antiphospholipid Syndrome (APS)
Other medical causes: malignancy, renal allograft rejection, vasculitides like polyarteritis nodosa and Wegener's granulomatosis
Drugs: chemotherapy; Clopidogrel (Plavix) associated with TTP
Nonvascular causes: prosthetic valve (more common with mechanical, more common at aortic valve), LVAD, TIPS, coil embolization, patched AV shunt, AVM
Marrow infiltration (tumor or infection)
Viral infections (rubella, HIV)
Marrow suppression (commonly chemotherapy or radiation)
Congenital thrombocytopenia
Fanconi anemia
Alport syndrome
Bernand Soulier
Vitamin B12 and/or folate deficiency
Fanconi anemia
Alport syndrome
Bernand Soulier
Idiopathic thrombocytopenic purpura
Thrombotic Thrombocytopenic Purpura (TTP)
Hemolytic Uremic Syndrome (HUS)<unk>  <unk> 
Viral infections (HIV, mumps, varicella, EBV)
Drugs (heparin, protamine)
Postransfusion or Posttransplantation
Autoimmune destruction (SLE or Sarcoidosis)
Mechanical destruction
Artificial valves
ECMO
HELLP syndrome
Excessive hemorrhage
Hemodialysis, extracorporeal circulation
Splenic Sequestration
Occurs in Sickle cell disease and Cirrhosis
Artificial valves
ECMO
Occurs in Sickle cell disease and Cirrhosis
sulfa antibiotics, ETOH, ASA, thiazide diuretics/furosemide
Too few
Thrombocytopenia
Nonfunctional
Aspirin
Von Willebrand disease
Thrombocytopenia
Aspirin
Von Willebrand disease
Acquired (Drug Related)
Warfarin (Coumadin)
Unfractionated heparin
Low molecular weight heparin (i.e. enoxaparin (Lovenox), dalteparin)
Factor Xa Inhibitors (e.g. rivaroxaban, apixaban, fondaparinux, edoxaban)
Direct thrombin inhibitors (e.g. dabigatran, argatroban, bivalirudin)
Illness induced
Vitamin K deficiency<unk>  <unk> 
Liver disease induced coagulopathy
Uremic bleeding syndrome
Genetic
Hemophilia
Factor VIII inhibitor
Lupus anticoagulant
Warfarin (Coumadin)
Unfractionated heparin
Low molecular weight heparin (i.e. enoxaparin (Lovenox), dalteparin)
Factor Xa Inhibitors (e.g. rivaroxaban, apixaban, fondaparinux, edoxaban)
Direct thrombin inhibitors (e.g. dabigatran, argatroban, bivalirudin)
Vitamin K deficiency<unk>  <unk> 
Liver disease induced coagulopathy
Uremic bleeding syndrome
Hemophilia
Factor VIII inhibitor
Lupus anticoagulant
Febrile
Diffuse distribution
Varicella
Smallpox<unk>  gonococcal disease<unk> 
Purpural fulminans
Localized distribution
Necrotizing fasciitis
Hand-foot-and-mouth disease
Varicella
Smallpox<unk>  gonococcal disease<unk> 
Purpural fulminans
Necrotizing fasciitis
Hand-foot-and-mouth disease
Afebrile
Diffuse distribution
Bullous pemphigoid
Drug-Induced bullous disorders
Pemphigus vulgaris
Phytophotodermatitis
Erythema multiforme major
Bullous impetigo
Localized distribution
Contact dermatitis
Herpes zoster
Dyshidrotic eczema
Burn
Dermatitis herpetiformis
Erythema multiforme minor
Poison Oak, Ivy, Sumac dermatitis
Bullosis diabeticorum
Bullous impetigo
Folliculitis
Bullous pemphigoid
Drug-Induced bullous disorders
Pemphigus vulgaris
Phytophotodermatitis
Erythema multiforme major
Bullous impetigo
Contact dermatitis
Herpes zoster
Dyshidrotic eczema
Burn
Dermatitis herpetiformis
Erythema multiforme minor
Poison Oak, Ivy, Sumac dermatitis
Bullosis diabeticorum
Bullous impetigo
Folliculitis
Disseminated intravascular coagulation
Disseminated Intravascular Coagulation 
Heparin-Induced Thrombocytopenia 
Thrombotic Thrombocytopenic Purpura 
Immune thrombocytopenic purpura
Hemolytic Uremic Syndrome 
Thrombotic thrombocytopenic purpura
HELLP syndrome