<unk>  is a rare central nervous system disease caused by the thermophilic free-living amoeba Naegleria fowleri
The amoeba lives in freshwater and can enter the brain through the cribriform plate after water containing it enters the nose; the amoeba causes direct tissue damage with hemorrhage and necrosis of brain tissue 
Exposure can occur from natural water sources (lakes, ponds, puddles) as well as man-made sources (swimming pools)
Cases nearly always result in death - in the USA 141/145 known cases were fatal
>50% cases in the USA occur in Texas and Florida
Primary Amebic Meningoencephalitis
Encephalitis
Drug induced aseptic meningitis
Meningitis
Neoplastic meningitis
Brain abscess
Limbic encephalitis
Sepsis