Suspect in patients with history of recurrent peripheral<unk>  and abdominal pain
75% experience onset of symptoms before age 15yr
C4 level screens for HAE (suspect if low)
Decreased levels of C1 and C4 esterase inhibitors confirms diagnosis
75% experience onset of symptoms before age 15yr
Incidence is highest within the first month; however, may occur at anytime
40% present months to years after initial dose
Incidence is 0.1-2.2% (more common in blacks)
Physiology more closely related to bradykinin-mediated pathway than IgE-mediated pathway, therefore current treatments may be insufficient
Angioedema
Allergic reaction/urticaria
Lymphedema
Anaphylaxis
Lymphangitis
Cyanosis
Anxiety attack
Asthma exacerbation