Acquired: liver failure results in shunting of blood from the liver to the inferior vena cava, decreased filtration of blood and removal of nitrogen-containing toxins by the liver, and then<unk> .
Congenital: Defect in one of the enzymes of the urea cycle, which leads to lower production of urea from ammonia.
Primary
Caused by several inborn errors of metabolism
Characterized by reduced activity of urea cycle enzymes
Secondary
Caused by inborn errors of intermediary metabolism (i.e. reduced activity of enzymes that are not part of the urea cycle)
Typically from acute or chronic liver failure
Caused by several inborn errors of metabolism
Characterized by reduced activity of urea cycle enzymes
Caused by inborn errors of intermediary metabolism (i.e. reduced activity of enzymes that are not part of the urea cycle)
Typically from acute or chronic liver failure
Hyperammonemia
Liver failure
Ketonemia
Inborn errors of metabolism with urea cycle defects and organic acidemia
Lactic acidosis
Shock, severe dehydration
Ketoacidosis
Renal failure