>67kg: 15mg IV over 1-2min; then 50mg IV over 30min; then 35mg over next 60min (i.e. 100mg over 1.5hr)
≤67kg: 15mg IV over 1-2min; then 0.75 mg/kg (max 50mg) IV over 30 min; then 0.5 mg/kg over 60min (max 35 mg)
0.9mg/kg IV (max 90mg total)
10% of dose is administered as bolus; rest is given over 60 minutes
10% of dose is administered as bolus; rest is given over 60 minutes
Stable Massive PE: 100mg IV over 2 hr OR 0.6mg/kg over 2 min
Cardiac arrest: 50mg IV over 2 min followed by 50mg IV after 15 min if needed
1.5 mg/hour by transcatheter intra-arterial infusion until lysis of thrombus
Alteplase
Tenecteplase
Argatroban
Prasugrel
Reteplase
Rivaroxaban
Ticagrelor
Ticlopidine