SLICC Classification Criteria 2012 
Requirements: >4 of the following criteria (at least 1 clinical and 1 laboratory) OR biopsy proven<unk>  nephritis with 
positive ANA or Anti-dsDNA
Clinical criteria
Malar rash, bullous<unk> , photosensitivity
Discoid rash, hypertrophic<unk> 
Oral ulcers or nasal ulcers
Non-scarring alopecia
Synovitis
Serositis
Nephritis
Cerebritis, myelitis, neuropathy
Hemolytic anemia
Leukopenia or lymphopenia
Thrombocytopenia
Malar rash, bullous<unk> , photosensitivity
Discoid rash, hypertrophic<unk> 
Oral ulcers or nasal ulcers
Non-scarring alopecia
Synovitis
Serositis
Nephritis
Cerebritis, myelitis, neuropathy
Hemolytic anemia
Leukopenia or lymphopenia
Thrombocytopenia
Immunological criteria
ANA
Anti-dsDNA
Anti-Sm
Antiphospholipid antibody
Low complement C3, low C4
Direct Coombs' test in the absence of haemolytic anaemia
ANA
Anti-dsDNA
Anti-Sm
Antiphospholipid antibody
Low complement C3, low C4
Direct Coombs' test in the absence of haemolytic anaemia
Organ system affected:
Cardiopulmonary
Pneumonia
Cover for Listeria and Pseudomonas
CAD
More common and more complications post-PCI
PE
Pericarditis
Endocarditis
Infectious and Libman-Sachs
Pneumonia
Cover for Listeria and Pseudomonas
CAD
More common and more complications post-PCI
PE
Pericarditis
Endocarditis
Infectious and Libman-Sachs
Cover for Listeria and Pseudomonas
More common and more complications post-PCI
Infectious and Libman-Sachs
Neuropsychiatric/Altered mental status
Non-convulsive status epilepticus
CNS vasculitis
Stroke
Encephalitis
Meningitis
Non-convulsive status epilepticus
CNS vasculitis
Stroke
Encephalitis
Meningitis
Musculoskeletal
Arthritis
Usually symmetric
Consider septic arthritis if there is a single inflamed joint
Cover for Salmonella in addition to standard coverage
Arthritis
Usually symmetric
Consider septic arthritis if there is a single inflamed joint
Cover for Salmonella in addition to standard coverage
Usually symmetric
Consider septic arthritis if there is a single inflamed joint
Cover for Salmonella in addition to standard coverage
Cover for Salmonella in addition to standard coverage
GI<unk>  enteritis (mesenteric vasculitis)
Most common cause of acute abdominal pain
Pancreatitis
PUD<unk>  enteritis (mesenteric vasculitis)
Most common cause of acute abdominal pain
Pancreatitis
PUD
Most common cause of acute abdominal pain
Dermatologic
Malar rash across bridge of nose
Discoid rash,<unk>  with scale
Malar rash across bridge of nose
Discoid rash,<unk>  with scale
Renal
Usually a nephritis
Can cause a glomerulonephrosis
Usually a nephritis
Can cause a glomerulonephrosis
Systemic lupus erythematosus
Rheumatoid arthritis
Polymyalgia rheumatica
Sjögren Syndrome
Scleroderma
Dermatomyositis
Juvenile idiopathic arthritis
Polymyositis