Dosing protocols vary
Start: 7-9mg/kg/day PO divided BID; give 1st dose 4-12 hr pre-transplant or postop
For heart, kidney, or liver transplant, adjust dose based on target levels, rejection status, adverse effects
Start: 2.5mg/kg/day PO divided BID, increase 0.5-0.75mg/kg/day after 8 wk and after 12 wk; Max: 4mg/kg/day
Use alone or with methotrexate; decreased 25-50% PRN adverse effects, discontinue if no benefit by 16 wks
Start: 2.5mg/kg/day PO divided BID, increase 0.5mg/kg/day q 2 wk after 4 wk; Max: 4mg/kg/day
Decrease 25-50% PRN adverse effects, discontinue if inadequate response after 6 weeks on max tolerated dose
Cyclosporine
Tacrolimus
Rituximab
Mycophenolate mofetil
Cyclophosphamide
Interferon-α
Azathioprine
Intravenous immunoglobulin