Active major bleeding
Hepatic impairment, Child-Pugh Class B or C
Coagulopathy-assoc. hepatic disease
CrCl <30 (DVT prophylaxis, recurrent DVT/PE prophylaxis, DVT/PE treatment use)
CrCl <15 (thromboembolism/stroke prophylaxis use)
Acute PE with hemodynamic instability
Acute PE requiring thrombolysis or pulmonary embolectomy
Rivaroxaban
Apixaban
Enoxaparin
Ticlopidine
Ticagrelor
Eptifibatide
Clopidogrel
Argatroban