Pregnancy:
Lactation:
Renal Dosing
Adult
CrCl ≥ 60 mL/min: No adjustment
CrCl 21 to 59 mL/min:
Chewable tablet: not recommended
Suspension: 260 mg once daily
CrCl ≤ 20
Chewable tablet: 200 mg once daily
100 mg/5 mL suspension: 172 mg once daily
200 mg/5 mL suspension: 176 mg once daily
500 mg/5 mL suspension: 180 mg once daily
Hemodialysis
Chewable tablet: not recommended
Suspension: 260 mg once daily
Pediatric
limited data
Mild to moderate impairment - no adjustment
Severe impairment and anuric - reduce dose 50%
Hepatic Dosing
Adult
Not defined
Pediatric
Not defined
Adult
CrCl ≥ 60 mL/min: No adjustment
CrCl 21 to 59 mL/min:
Chewable tablet: not recommended
Suspension: 260 mg once daily
CrCl ≤ 20
Chewable tablet: 200 mg once daily
100 mg/5 mL suspension: 172 mg once daily
200 mg/5 mL suspension: 176 mg once daily
500 mg/5 mL suspension: 180 mg once daily
Hemodialysis
Chewable tablet: not recommended
Suspension: 260 mg once daily
Pediatric
limited data
Mild to moderate impairment - no adjustment
Severe impairment and anuric - reduce dose 50%
CrCl ≥ 60 mL/min: No adjustment
CrCl 21 to 59 mL/min:
Chewable tablet: not recommended
Suspension: 260 mg once daily
CrCl ≤ 20
Chewable tablet: 200 mg once daily
100 mg/5 mL suspension: 172 mg once daily
200 mg/5 mL suspension: 176 mg once daily
500 mg/5 mL suspension: 180 mg once daily
Hemodialysis
Chewable tablet: not recommended
Suspension: 260 mg once daily
Chewable tablet: not recommended
Suspension: 260 mg once daily
Chewable tablet: 200 mg once daily
100 mg/5 mL suspension: 172 mg once daily
200 mg/5 mL suspension: 176 mg once daily
500 mg/5 mL suspension: 180 mg once daily
Chewable tablet: not recommended
Suspension: 260 mg once daily
limited data
Mild to moderate impairment - no adjustment
Severe impairment and anuric - reduce dose 50%
Adult
Not defined
Pediatric
Not defined
Not defined
Not defined
Cefixime
Meropenem
Cefepime
Aztreonam
Levofloxacin
Cefazolin
Cefotaxime
Doripenem