Treat non-ambulatory patients within 2 weeks of symptom onset
IVIG associated with thromboembolism and aseptic meningitis
Plasmapheresis associated with greater hemodynamic instability, lower rate of relapse
Combined IVIG and plasmapheresis no better than single therapy (IVIG or plasmapheresis)
IVIG preferred due to convenience and availability
Vital capacity <15mL/kg
Negative Inspiratory Force < 30 cm H2O
PaO2 <70 mm Hg on room air
Bulbar dysfunction (difficulty with breathing, swallowing, or speech)
Aspiration
Avoid succinylcholine during intubation, as this may cause severe hyperkalemia
Guillain-Barre syndrome
Neuromuscular weakness
Lambert-Eaton myasthenic syndrome
Upper motor neuron:
Amyotrophic lateral sclerosis
CVA
Polymyositis
Hemorrhagic stroke