Bleeding
Risk increased when INR >3
Exponential increase when INR >5
Avoid giving NSAIDs, sulfas, macrolidies (azithromycin ok), fluoroquinolones
Skin necrosis
Usually in patient with protein C deficiency
Occurs 3 - 8 days after starting treatment
Treatment: see<unk>  (Coumadin) Reversal
Risk increased when INR >3
Exponential increase when INR >5
Avoid giving NSAIDs, sulfas, macrolidies (azithromycin ok), fluoroquinolones
Usually in patient with protein C deficiency
Occurs 3 - 8 days after starting treatment
Warfarin
Clopidogrel
Ticlopidine
Apixaban
Enoxaparin
Ticagrelor
Rivaroxaban
Eptifibatide