Increased risk of developing serious skin rashes
Oral
Children 2-12 years: Immediate release formulation
Non-enzyme inducing AED adjuncts: Week 1-2, 0.3mg/kg/day, week 3-4, 0.6mg/kg/day, then increased by 0.6mg/kg/day every 1-2 weeks; maintenance 4.5-7.5mg/kg/day
Valproate adjunct: Week 1-2, 0.15mg/kg/day, week 3-4, 0.3mg/kg/day, then increased by 0.3mg/kg/day every 1-2 weeks; maintenance 1-5mg/kg/day
Enzyme inducing AED adjunct: Week 1-2, 0.6mg/kg/day, week 3-4, 1.2mg/kg/day, then increased by 1.2mg/kg/day every 1-2 weeks; maintenance 5-15mg/kg/day
Adolescents >12 years: Refer to adult dosing
Children 2-12 years: Immediate release formulation
Non-enzyme inducing AED adjuncts: Week 1-2, 0.3mg/kg/day, week 3-4, 0.6mg/kg/day, then increased by 0.6mg/kg/day every 1-2 weeks; maintenance 4.5-7.5mg/kg/day
Valproate adjunct: Week 1-2, 0.15mg/kg/day, week 3-4, 0.3mg/kg/day, then increased by 0.3mg/kg/day every 1-2 weeks; maintenance 1-5mg/kg/day
Enzyme inducing AED adjunct: Week 1-2, 0.6mg/kg/day, week 3-4, 1.2mg/kg/day, then increased by 1.2mg/kg/day every 1-2 weeks; maintenance 5-15mg/kg/day
Adolescents >12 years: Refer to adult dosing
Lamotrigine
Topiramate
Ethosuximide
Carbamazepine
Levetiracetam
Phenytoin
Oxcarbazepine
Valproic acid