Class: Imidazolines<unk> 
Guanfacine
Oxymetazoline(Afrin)
Tetrahydrolozine (Visine)
Naphazoline (Naphcon)
Apraclonidine
α-2, imidazoline, and opioid receptor agonist
α2-agonism leads to activation of inhibitory neurons in the nucleus tractus solitarius causing decreased norepinephrine release, precipitating decreased sympathetic outflow
Agonism of imidazoline receptors in the brain can cause unconsciousness, hypotension, and bradycardia<unk>  is used therapeutically for hypertension, opioid abuse, PTSD, and tobacco withdrawal; criminally, it has been used for drug-facilitated sexual assault<unk> 
Guanfacine
Oxymetazoline(Afrin)
Tetrahydrolozine (Visine)
Naphazoline (Naphcon)
Apraclonidine
α2-agonism leads to activation of inhibitory neurons in the nucleus tractus solitarius causing decreased norepinephrine release, precipitating decreased sympathetic outflow
Agonism of imidazoline receptors in the brain can cause unconsciousness, hypotension, and bradycardia
Clonidine toxicity
Cholinergic crisis
Tricyclic antidepressant toxicity
Yohimbine toxicity
Antipsychotic toxicity
Flunitrazepam toxicity
Beta-blocker toxicity
Caffeine withdrawal