Consider<unk>  in a patient of any age who has an acute RASH and FEVER
Risk factors
In the prior 3 weeks: travel outside of North America, transit through U.S. international airports, interaction with foreign visitors, including at a U.S. tourist attraction, or travel to areas of the U.S with ongoing<unk>  transmission.
Confirmed<unk>  cases in your community.
Never immunized with<unk>  vaccine and born in 1957 or later.
Incubation period - 10 days
Prodrome of high fever, cough, coryza, and conjunctivitis (lasts ~3 days)
Koplik's spots (appears day 2-3) - pathognomonic enanthem
Tiny red spots (base) with bluish-white centers on the mucosa of the cheek or palate
Rash (begins day 4 - lasts to day 7)
Red, blotchy, and maculopapular; rapidly progresses to confluence
Usually starts on the face (hairline and behind the ears)
Rapidly spreads to the chest, back, and finally the legs and feet
Rash resolves in order of appearance between days 7-9
In the prior 3 weeks: travel outside of North America, transit through U.S. international airports, interaction with foreign visitors, including at a U.S. tourist attraction, or travel to areas of the U.S with ongoing<unk>  transmission.
Confirmed<unk>  cases in your community.
Never immunized with<unk>  vaccine and born in 1957 or later.
Tiny red spots (base) with bluish-white centers on the mucosa of the cheek or palate
Red, blotchy, and maculopapular; rapidly progresses to confluence
Usually starts on the face (hairline and behind the ears)
Rapidly spreads to the chest, back, and finally the legs and feet
Rash resolves in order of appearance between days 7-9
Secondary infection<unk>  virus can directly infect T cells, leading to systemic immune suppression and secondary infections
Gastrointestinal
Diarrhea is the most common complication
Others: gingivostomatitis, gastroenteritis, hepatitis, mesenteric lymphadenitis, and appendicitis
Pulmonary
Pneumonia is the most common cause of<unk> -associated death in children
Neurologic
Encephalitis
Acute disseminated encephalomyelitis
Demyelinating disease thought to be a postinfectious autoimmune response
Subacute sclerosing panencephalitis
A fatal, progressive degenerative disease of the CNS that usually occurs 7 to 10 years after natural<unk>  virus infection<unk>  virus can directly infect T cells, leading to systemic immune suppression and secondary infections
Diarrhea is the most common complication
Others: gingivostomatitis, gastroenteritis, hepatitis, mesenteric lymphadenitis, and appendicitis
Pneumonia is the most common cause of<unk> -associated death in children
Encephalitis
Acute disseminated encephalomyelitis
Demyelinating disease thought to be a postinfectious autoimmune response
Subacute sclerosing panencephalitis
A fatal, progressive degenerative disease of the CNS that usually occurs 7 to 10 years after natural<unk>  virus infection
Demyelinating disease thought to be a postinfectious autoimmune response
A fatal, progressive degenerative disease of the CNS that usually occurs 7 to 10 years after natural<unk>  virus infection
Measles
Atopic dermatitis
Smallpox
Bed bugs
Scabies
Contact dermatitis
Rat bite fever
Drug rash