<unk> , also known as acquired epidermolysis<unk> , is a longterm autoimmune blistering skin disease. It generally presents with fragile skin that blisters and becomes red with or without trauma. Marked scarring is left with thin skin, milia and nail changes. It typically begins around age 50-years. It is caused by antibodies to type VII collagen within anchoring fibril structures located at the dermoepidermal junction in skin. Damaged skin may become infected. Diagnosis is by observing the persistence of the condition, direct immunofluorescence, and detecting autoantibodies against type VII collagen. It can appear similar to porphyria cutanea tarda, pemphigoid, pemphigus, dermatitis herpetiformis, or blistering drug eruption. The condition is longterm and has no cure. A good response may be seen with corticosteroids, either alone or combined with azathioprine or dapsone. It is rare, with around 0.08 to 0.5 new cases per million people per year, and it affects males and females equally.
Epidermolysis bullosa acquisita
Epidermolysis bullosa simplex
Ichthyosis acquisita
Ichthyosis bullosa of Siemens
Junctional epidermolysis bullosa 
Epidermolysis bullosa dystrophica
Urticaria pigmentosa
Dermatopathia pigmentosa reticularis