<unk>  is a selective agonist at the imidazoline receptor subtype 1 (I1). This receptor subtype is found in both the rostral ventro-lateral pressor and ventromedial depressor areas of the medulla oblongata.<unk>  therefore causes a decrease in sympathetic nervous system activity and, therefore, a decrease in blood pressure. Compared to the older central-acting antihypertensives,<unk>  binds with much greater affinity to the imidazoline I1-receptor than to the α2-receptor. In contrast, clonidine binds to both receptors with near equal affinity.<unk>  has an affinity for I1 that is 33 times greater than α2, compared to clonidine which is only four times greater. In addition,<unk>  may also promote sodium excretion, improve insulin resistance and glucose tolerance and protect against hypertensive target organ damage, such as kidney disease and cardiac hypertrophy.
Moxonidine
Pramocaine
Carctol
Ibogaine
Bromelain 
Iontocaine
Tesofensine
Lofexidine