NLR family pyrin domain containing 3<unk>  (previously known as NACHT, LRR and PYD domains-containing protein 3 NALP3 and cryopyrin), is a protein that in humans is encoded by the<unk>  gene located on the long arm of chromosome 1.<unk>  is expressed predominantly in macrophages and as a component of the inflammasome, detects products of damaged cells such as extracellular ATP and crystalline uric acid. Activated<unk>  in turn triggers an immune response. Mutations in the<unk>  gene are associated with a number of organ specific autoimmune diseases.
NLRP3
Caspase-9
PTPRC
Rho
MFAP4
IKK2
ILC2
Fc receptor