Normal Ear Anatomy Earlobe creases seen in a Japanese angina patient<unk>  is a diagonal crease in the ear lobe extending from the tragus across the lobule to the rear edge of the auricle. The sign is named after Sanders T.<unk> . It has been hypothesised that<unk>  is indicative of cardiovascular disease and/or diabetes. Some studies have described<unk>  as a marker of cardiovascular disease but not linked to the severity of the condition. In contrast, other studies have rebutted any association between<unk>  and coronary artery disease in diabetics. There have also been reported cases of<unk>  being a predictor of cerebral infarctions. A link between<unk>  and premature aging and the loss of dermal and vascular fibers has also been hypothesized. Some studies have focused on association between bilateral earlobe crease and coronary artery disease. It is probably prudent to consider<unk>  alongside other clinical markers of physiological ageing, rather than utilising it as a stand-alone sign in the identification of coronary artery disease.
Frank's sign
Adson's sign
Fothergill's sign
Pemberton's sign
Bing's sign
Bancroft's sign
Cullen's sign
Kelly's sign