<unk> , also known as pernio, is a medical condition in which damage occurs to capillary beds in the skin, most often in the hands or feet, when blood perfuses into the nearby tissue resulting in redness, itching, inflammation, and possibly blisters. If left untreated, pernio can spread towards the rectum, or other areas left unsanitary. It occurs most frequently when predisposed individuals, predominantly women, are exposed to cold and humidity. Ulcerated<unk>  are referred to as kibes. Temperature-related<unk>  can be prevented by keeping the feet and hands warm in cold weather and avoiding exposing these areas to extreme temperature changes. Once the diagnosis of<unk>  is made, first-line treatment includes avoiding cold, damp environments and wearing gloves and warm socks.<unk>  can be idiopathic (spontaneous and unrelated to another disease), but similar symptoms may also be a manifestation of another serious medical condition that must be investigated. Related medical conditions include Raynaud syndrome, erythromelalgia, frostbite, and trench foot, as well as connective tissue diseases such as lupus or vasculitis. In infants affected by Aicardi–Goutières syndrome (a rare inherited condition which affects the nervous system)<unk> like symptoms occur together with severe neurologic disturbances and unexplained fevers.
Chilblains
Frostbite
Straitjacket
Scrapie
Flat wart
Harmoni
Ephedra 
Cowlick