Mechanism of action<unk>  is selective for two types of retinoic acid receptors, RAR-γ and RAR-β. Like all retinoids, it affects the ability of keratinocytes in the epidermis to proliferate and differentiate. It does so by upregulating filaggrin expression and downregulating the expression of keratinocyte transglutaminase, ornithine decarboxylase, involucrin, epidermal growth factor receptor, and various keratins. Pharmacokinetics More than 99% of<unk> c acid, the active metabolite of<unk> , in the blood binds to plasma proteins (the most predominant being albumin). The volume of distribution (VD) for<unk>  is 26.1 L/kg and the VD for<unk> c acid is 1.97 L/kg.<unk>  is excreted from the body via feces and urine equally, and it has an elimination half-life of 16 to 18 hours.
Tazarotene
Trifarotene
Bexarotene
Retinol
Β-Carotene
Calcipotriol
Stenbolone
Stenbolone acetate