Typical<unk>  is classically defined as symmetrical skin thickening, with about 70% of cases also presenting with Raynaud's phenomenon, nail-fold capillary changes, and antinuclear antibodies. Affected individuals may experience systemic organ involvement. No single test for<unk>  works all of the time, hence diagnosis is often a matter of exclusion. Atypical<unk>  may show any variation of these changes without skin changes or with finger swelling only. Laboratory testing can show antitopoisomerase antibodies, like anti-scl70 (causing a diffuse systemic form), or anticentromere antibodies (causing a limited systemic form and the CREST syndrome). Other autoantibodies can be seen, such as anti-U3 or anti-RNA polymerase. Antidouble-stranded DNA autoantibodies are likely to be present in serum. Differential Diseases that are often in the differential include: * Eosinophilia is a condition in which too many eosinophils (a type of immune cell that attacks parasites and is involved in certain allergic reactions) are present in the blood. * Eosinophilia-myalgia syndrome is a form of eosinophilia caused by L-tryptophan supplements. * Eosinophilic fasciitis affects the connective tissue surrounding skeletal muscles, bones, blood vessels, and nerves in the arms and legs. * Graft-versus-host disease is an autoimmune condition that occurs as a result of bone-marrow transplants in which the immune cells from the transplanted bone marrow attack the host's body. * Mycosis fungoides is a type of cutaneous T cell lymphoma, a rare cancer that causes rashes all over the body. * Nephrogenic systemic fibrosis is a condition usually caused by kidney failure that results in fibrosis (thickening) of the tissues. * Primary biliary cirrhosis is an autoimmune disease of the liver. * Primary pulmonary hypertension * Complex regional pain syndrome Classification<unk>  is characterised by the appearance of circumscribed or diffuse, hard, smooth, ivory-colored areas that are immobile and which give the appearance of hidebound skin, a disease occurring in both localised and systemic forms: * Localised<unk>  * Localised morphea * Morphea-lichen<unk> erosus et atrophicus overlap * Generalised morphea * Atrophoderma of Pasini and Pierini * Pansclerotic morphea * Morphea profunda * Linear<unk>  * Systemic<unk>  * CREST syndrome * Progressive systemic<unk> erosis
Scleroderma
Mixed connective tissue disease
Chyloderma
Dermatomyositis
Anetoderma
Polymyositis
Xeroderma
Lupus