Premature ejaculation Randomized, double-blind, placebo-controlled trials have confirmed the efficacy of<unk>  for the treatment of PE. Different dosages have different impacts on different types of PE.<unk>  60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of<unk>  30 mg in men with lifelong PE, but no difference is seen in men with acquired PE.<unk> , given 1–3 hours before sexual episode, prolongs IELT and increases the sense of control and sexual satisfaction in men of 18 to 64 years of age with PE. Since PE is associated with personal distress and interrelationship difficulty,<unk>  provides help for men with PE to overcome this condition. With no drug approved specifically for treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used off-label to treat PE. Waldinger's meta-analysis shows that the use of these conventional antidepressants increases IELT two- to nine-fold above baseline, compared to three- to eight-fold when<unk>  is used. However, these SSRIs may need to be taken daily to achieve meaningful efficacy, and their comparatively longer half-lives increase the risk of drug accumulation and a corresponding increase of adverse effects such as reduced libido.<unk> , though, is generally categorized as a fast-acting SSRI. It is more rapidly absorbed and mostly eliminated from the body within a few hours. These pharmacokinetics are more favorable in that they might minimize drug accumulation in the body, habituation, and side effects. Depression and anxiety Although it was initially thought of as unsuccessful in its intended use as an antidepressant,<unk>  has been more recently investigated as a possible aid to one approach to depression treatment focused on stress reduction, based on an animal model of depression. As of October 2018,<unk>  is listed as a SSRI used to treat depression and anxiety by the UK's NHS.
Dapoxetine
Atomoxetine
Duloxetine
Edivoxetine
Vortioxetine
Fluoxetine
Nabilone
Guanfacine