Indigenous victims, Florentine Codex (compiled 1540–1585) The<unk>  or the great pestilence, is a term given to millions of deaths in the territory of New Spain in present-day Mexico in the 16th century attributed to one or more illnesses collectively called<unk> , a mysterious illness characterized by high fevers and bleeding. It ravaged the Mexican highlands in<unk> proportions. The disease became known as<unk>  by the native Aztecs, and had devastating effects on the area’s demography, particularly for the indigenous people. Based on the death toll, this outbreak is often referred to as the worst disease<unk> in the history of Mexico. Subsequent outbreaks continued to baffle both Spanish and native doctors, with little consensus among modern researchers on the pathogenesis. However, recent bacterial genomic studies have suggested that Salmonella, specifically a serotype of Salmonella enterica known as Paratyphi C, was at least partially responsible for this initial outbreak. It might have also been an indigenous viral hemorrhagic fever, perhaps exacerbated by the worst droughts to affect that region in 500 years, as well as living conditions for indigenous peoples of Mexico in the wake of the Spanish conquest (c. 1519).
Cocoliztli epidemics
Tanganyika laughter epidemic
Native American disease and epidemics
Virgin soil epidemic
Death rattle
symptoms of Yellow fever
Asclepiades of Bithynia
Flavescence dorée