<unk> <unk><unk>  can be localized or systemic.<unk>  can present with a wide range of symptoms in multiple body systems, these symptoms may range from digestive discomfort to chronic pain, mental issues as well as an anaphylactic reaction ( The<unk> ocytosis Society). Some examples of tissue specific consequences of<unk> <unk><unk>  include urticaria, allergic rhinitis, and wheezing. Systemic<unk> <unk><unk>  presents with symptoms involving 2 or more organ systems (skin: urticaria, angioedema, and flushing; gastrointestinal: nausea, vomiting, diarrhea, and abdominal cramping; cardiovascular: hypotensive syncope or near syncope and tachycardia; respiratory: wheezing; naso-ocular: conjunctival injection, pruritus, and nasal stuffiness). This can result from the release of mediators from a specific site, such as the skin or mucosal tissue, or<unk>  of<unk> <unk> s around the vasculature.
Mast cell activation syndrome
CREST syndrome
Cytokine release syndrome
MOMO syndrome
SUNCT syndrome
Macrophage activation syndrome
Systemic inflammatory response syndrome
OSLAM syndrome