<unk> <unk><unk> s are coupled to Gi/o heterotrimeric proteins. They function as inhibitory autoreceptors for<unk> . Activation of<unk> <unk> s inhibits<unk>  release in the striatum. The M2 subtype of<unk><unk>  functions similarly as an inhibitory autoreceptor to<unk>  release, albeit functioning actively primarily in the hippocampus and cerebral cortex.<unk><unk><unk> s possess a regulatory effect on dopaminergic neurotransmission. Activation of<unk> <unk> s in the striatum inhibit D1-induced locomotor stimulation in mice.<unk> <unk> -deficient mice exhibit increased locomotor simulation in response to D1 agonists, amphetamine and cocaine. Neurotransmission in the striatum influences extrapyramidal motor control, thus alterations in<unk>  activity may contribute to conditions such as Parkinson's disease.
Muscarinic acetylcholine receptor M4
5-HT3 receptor
Type Ia sensory fiber
Trace amine-associated receptor
SK channel
Baroreceptor
Prolactin-releasing peptide receptor
Mechanosensitive channels