Diagram of Cushing's symptoms. Picture of lentigines associated with Carney Complex<unk>  is a rare cause of high cortisol levels in the blood and often manifests as ACTH-independent Cushing's syndrome. The effects of<unk>  can often be cyclical so the symptoms of Cushing's syndrome will not always be as severe, which may complicate diagnosis. The classic symptoms of Cushing's syndrome include rapid central weight gain, a puffy red face and a buffalo hump at the back of the neck due to fat deposits. Skin changes in Cushing's syndrome include thinning and bruising easily, developing striae and hyperpigmentation at skin folds. The hormonal changes can lead to hirsutism, males developing breast tissue, females no longer having periods and both sexes may become infertile. High cortisol levels can lead to psychological disturbances such as anxiety or depression and insomnia. Bone health can deteriorate, leading to an increased fracture risk in people with Cushing's syndrome.<unk>  is unique as it often causes Cushing's at a young age, in children and adolescents. In addition to the other symptoms of Cushing's syndrome, the patient may have a short stature due to interrupted growth because of ACTH suppression. In 90% of people with<unk>  it is associated with Carney Complex. Carney Complex is usually inherited, however it can also occur sporadically. A visible sign of Carney complex is abnormal skin hyperpigmentation. There may also be myxomas which can appear as lumps in the skin and breast as well as often being present in the heart, which can lead to multiple cardiovascular problems. The majority of people with<unk>  will have some of these signs/symptoms due to the strong association between<unk>  and Carney Complex.
Primary pigmented nodular adrenocortical disease
Lipoid congenital adrenal hyperplasia
Late onset congenital adrenal hyperplasia
Multiple endocrine neoplasia
Multiple endocrine neoplasia type 1
Adrenocortical adenoma
Multiple endocrine neoplasia type 2
Congenital adrenal hyperplasia