The spherical virus particles (virions) of Matonaviridae have a diameter of 50 to 70 nm and are covered by a lipid membrane (viral envelope), derived from the host cell membrane. There are prominent "spikes" (projections) of 6 nm composed of the viral envelope proteins E1 and E2 embedded in the membrane. The E1 glycoprotein is considered immunodominant in the humoral response induced against the structural proteins and contains both neutralizing and hemagglutinating determinants. Genus Structure Symmetry Capsid Genomic arrangement Genomic segmentation<unk> ivirus Icosahedral T=4 Enveloped Linear Monopartite Capsid protein Inside the lipid envelope is a capsid of 40 nm in diameter. The capsid protein (CP) has different functions. Its main tasks are the formation of homooligomeres to form the capsid, and the binding of the genomic RNA. Further is it responsible for the aggregation of RNA in the capsid, it interacts with the membrane proteins E1 and E2 and binds the human host-protein p32 which is important for replication of the virus in the host. As opposed to alphaviruses the capsid does not undergo autoproteolysis, rather is it cut off from the rest of the polyprotein by the signal-peptidase. Production of the capsid happens at the surface of intracellular membranes simultaneously with the budding of the virus.
Rubella virus
Mumps virus
Hendra virus
Western equine encephalitis virus
Venezuelan equine encephalitis virus
West Nile virus
Playa de Oro virus
Rabies virus