<unk> (also sometimes referred to as proteolytic enzymes or peptidases) are in use, or have been proposed or tried, for a number of purposes related to medicine or surgery. Some preparations involving<unk> have undergone successful clinical trials and have regulatory authorization; and some further ones have shown apparently useful effects in experimental medical studies.<unk> have also been used by proponents of alternative therapies, or identified in materials of traditional or folk medicine. A serine<unk> of human origin, activated protein C, was produced in recombinant form and marketed as Drotrecogin alfa (also known as Xigris (TM)) and licensed for intensive-care treatment of severe sepsis. It was voluntarily withdrawn by the manufacturer in 2011 after being shown to be ineffective. Some of these uses rely directly on the proteolytic activity: others rely on observations of anti-inflammatory activity.
Proteases 
Coagulase
Transfer factor
Hemostat
Lactase
Amidase
Serpin
Cytokine