The exact mechanism of<unk>  is not fully elucidated. There is evidence indicating both that it can be caused by anti-retroviral medications and that it can be caused by<unk>  infection in the absence of anti-retroviral medication. Evidence implicating anti-retroviral medications On the one hand, lipodystrophy seems to be mainly due to<unk> -1 protease inhibitors. Interference with lipid metabolism is postulated as pathophysiology. Also, the development of lipodystrophy is<unk>  with specific nucleoside reverse transcriptase inhibitors (NRTI). Mitochondrial toxicity is postulated to be involved in the pathogenesis<unk>  with NRTI. Evidence implicating<unk>  infection alone On the other hand, there is evidence that<unk> -1 infection on its own contributes to the development of the lipodystrophic phenotype by interfering with some key genes of adipocyte differentiation and mitochondrial function on patients which have not received antiretroviral treatment.
HIV-associated lipodystrophy
Drug-induced lipodystrophy
Corticosteroid-induced lipodystrophy
Acquired generalized lipodystrophy
Involutional lipoatrophy
Multiple endocrine neoplasia
Chemotherapy-induced hyperpigmentation
Paraneoplastic acrokeratosis