<unk>  is mainly involved in the glucuronidation of hyodeoxycholic acid, a bile acid, and catechol-estrogens, such as 17-epiestriol and 4-hydroxy-estrone. The expression of the<unk>  enzyme is upregulated by the farnesoid X receptor (FXR), a nuclear receptor which is activated by bile acids. These same bile acids are substrates for the<unk>  enzyme. Hence upregulation of<unk>  by activated FXR provides a mechanism for the detection, conjugation and subsequent elimination of toxic bile acids.
UGT2B4
UGT2B7
UGT1A4
UGT1A8
UGT1A9
CYP2C19
CYP2C8
CYP2D6