If elevated<unk> ctate is present in acute illness, supporting the oxygen supply and blood flow are key initial steps. Some vasopressors (drugs that augment the blood pressure) are less effective when<unk> ctate levels are high, and some agents that stimulate the beta-2 adrenergic receptor can elevate the<unk> ctate further. Direct removal of<unk> ctate from the body (e.g. with hemofiltration or dialysis) is difficult, with limited evidence for benefit; it may not be possible to keep up with the<unk> ctate production. Limited evidence supports the use of sodium bicarbonate solutions to improve the pH (which is associated with increased carbon dioxide generation and may reduce the calcium levels).<unk>  caused by inherited mitochondrial disorders (type B3) may be treated with a ketogenic diet and possibly with dichloroacetate (DCA), although this may be complicated by peripheral neuropathy and has a weak evidence base.
Lactic acidosis
Metabolic acidosis
Acidosis
Metabolic alkalosis
Azotemia
Hyperammonemia
Alkalosis
Hypercapnia