GCNIS is not palpable, and not visible on macroscopic examination of testicular tissue. Microscopic examination of affected testicular tissue most commonly shows<unk> <unk> s with enlarged hyperchromatic nuclei with prominent nucleoli and clear cytoplasm. These<unk> s are typically arranged along the basement membrane of the tubule, and mitotic figures are frequently seen. The sertoli<unk> s are pushed toward the lumen by the neoplastic<unk> <unk> s, and spermatogenesis is almost always absent in the affected tubules. Pagetoid spread of GCNIS into the rete testis is common. Immunostaining with placental alkaline phosphatase (PLAP) highlights GCNIS<unk>  membranes in 95 percent of cases. OCT3/4 is a sensitive and specific nuclear stain of GCNIS.
Germ cell neoplasia in situ
In situ lymphoid neoplasia
Surface epithelial-stromal tumor
Sclerosing polycystic adenosis
Keratin implantation cyst
Microcystic adnexal carcinoma
Ductal carcinoma in situ
Intraepithelial neoplasia