Medical and veterinary A bottle of PRN Pharmaceutical Company (Pensacola, FL) K•BroVet veterinary pharmaceutical<unk>  oral solution (250 mg/mL). The product is intended to be used in dogs, primarily as an antiepileptic (to stop seizures). The pink color of the solution is artificial; pure<unk>  solutions are colorless The anticonvulsant properties of<unk>  were first noted by Sir Charles Locock at a meeting of the Royal Medical and Chirurgical Society in 1857.<unk>  can be regarded as the first effective medication for epilepsy. At the time, it was commonly thought that epilepsy was caused by masturbation. Locock noted that<unk>  calmed sexual excitement and thought this was responsible for his success in treating seizures. In the latter half of the 19th century,<unk>  was used for the calming of seizure and nervous disorders on an enormous scale, with the use by single hospitals being as much as several tons a year (the dose for a given person being a few grams per day). By the beginning of the 20th century the generic word had become so widely associated with being sedate that<unk>  came to mean a dull, sedate person or a boring platitude uttered by such a person. There was not a better epilepsy drug until phenobarbital in 1912. The British Army has historically been claimed to lace soldiers' tea with<unk>  to quell sexual arousal but that is likely untrue as doing so would also diminish alertness in battle. Several other substances have also been named in anaphrodisiac myths.<unk>  compounds, especially sodium<unk> , remained in over-the-counter sedatives and headache remedies (such as the original formulation of Bromo-Seltzer) in the US until 1975, when<unk> s were outlawed in all over-the-counter medicines, due to chronic toxicity.<unk> 's exceedingly long half life in the body made it difficult to dose without side effects. Medical use of<unk> s in the US was discontinued at this time, as many better and shorter-acting sedatives were known by then.<unk>  is used in veterinary medicine to treat epilepsy in dogs, either as first-line treatment or in addition to phenobarbital, when seizures are not adequately controlled with phenobarbital alone. Use of<unk>  in cats is limited because it carries a substantial risk of causing lung inflammation (pneumonitis) in them. The use of<unk>  as a treatment drug for animals means that veterinary medical diagnostic laboratories are able as a matter of routine to measure serum levels of<unk>  on order of a veterinarian, whereas human medical diagnostic labs in the US do not measure<unk>  as a routine test.<unk>  is not approved by the US Food and Drug Administration (FDA) for use in humans to control seizures. In Germany, it is still approved as an antiepileptic drug for humans, particularly children and adolescents. These indications include severe forms of generalized tonic-clonic seizures, early-childhood-related tonic–clonic seizures, and also severe myoclonic seizures during childhood. Adults who have reacted positively to the drug during childhood/adolescence may continue treatment.<unk>  tablets are sold under the brand name Dibro-Be mono (Rx-only). The drug has almost complete bioavailability, but the<unk>  ion has a relatively long half life of 12 days in the blood, making<unk>  salts difficult to adjust and dose.<unk>  is not known to interfere with the absorption or excretion of any other anticonvulsant, though it does have strong interactions with chloride in the body, the normal body uptake and excretion of which strongly influences<unk> 's excretion. The therapeutic index (ratio of effectiveness to toxicity) for<unk>  is small. As with other antiepileptics, sometimes even therapeutic doses (3 to 5 grams per day, taking 6 to 8 weeks to reach stable levels) may give rise to intoxication. Often indistinguishable from 'expected' side-effects, these include: *Bromism These are central nervous system reactions. They may include: :depression, :lethargy, somnolence (from daytime sleepiness to coma) :loss of appetite and cachexia, nausea/emesis with exicosis (loss of body fluid) :loss of reflexes or pathologic reflexes :clonic seizures :tremor :ataxia :loss of neural sensitivity :paresis :cerebral edema with associated headache and papilledema of the eyes :delirium: confusion, abnormal speech, loss of concentration and memory, aggressiveness :psychosis *Acne-form dermatitis and other forms of skin disease may also be seen, as well as mucous hypersecretion in the lungs. Asthma and rhinitis may worsen. Rarely, tongue disorder, aphthous stomatitis, bad breath, and constipation occur. Optics<unk>  is transparent from the near ultraviolet to long-wave infrared wavelengths (0.25-25 µm) and has no significant optical absorption lines in its high transmission region. It is used widely as infrared optical windows and components for general spectroscopy because of its wide spectral range. In infrared spectroscopy, samples are analyzed by grinding with powdered<unk>  and pressing into a disc. Alternatively, samples may be analyzed as a liquid film (neat, as a solution, or in a mull with Nujol) between two polished<unk>  discs. Due to its high solubility and hygroscopic nature it must be kept in a dry environment. The refractive index is about 1.55 at 1.0 µm. Photography In addition to manufacture of silver<unk> ,<unk>  is used as a restrainer in black and white developer formulas. It improves differentiation between exposed and unexposed crystals of silver halide, and thus reduces fog.
Potassium bromide
Calcium chloride
Magnesium sulfate 
Magnesium sulfate
Bolazine
Ethyl loflazepate
Tianeptine
Benzonatate