<unk>  (or macrencephaly; abbreviated MEG) is a growth development disorder in which the brain is abnormally large. It is characterized by a brain with an average weight that is 2.5 standard deviations above the mean of the general population. Approximately 1 out of 50 children (2%) are said to have the characteristics of<unk>  in the general population. A mutation in the PI3K-AKT pathway is believed to be the primary cause of brain proliferation and ultimately the root cause of<unk> . This mutation has produced a classification of brain overdevelopment that consists of two syndromes including<unk> -capillary malformation (MCAP) and<unk> -polydactyly-polymicrogyria-hydrocephalus (MPPH).<unk>  is usually diagnosed at birth and is confirmed with an MRI. There are several neuropsychiatric disorders linked with<unk> ; however, studies have shown that autism is the most prevalent association with the malformation of MEG. Although no treatment currently exists for<unk> , management methods are focused at reducing deficits linked with autism. Most recent research is targeted at creating inhibitors to reduce the mutational pathway that causes<unk> .
Megalencephaly
Schizencephaly
Hemihydranencephaly
Microhydranencephaly
Hydranencephaly
Holoprosencephaly
Lissencephaly
Microlissencephaly