<unk> s or paroxysms (from Greek παροξυσμός) are a sudden recurrence or intensification of symptoms, such as a spasm or seizure. These short, frequent symptoms can be observed in various clinical conditions. They are usually associated with multiple sclerosis or pertussis, but they may also be observed in other disorders such as encephalitis, head trauma, stroke, asthma, trigeminal neuralgia, breath-holding spells, epilepsy, malaria, tabes dorsalis, and Behçet's disease,<unk>  nocturnal hemoglobinuria (PNH). It has also been noted as a symptom of gratification disorder in children. The word paroxysm means "sudden attack, outburst", and comes from the Greek παροξυσμός (paroxusmos), "irritation, exasperation".<unk> s in various disorders have been reported extensively and ephaptic coupling of demyelinated nerves has been presumed as one of the underlying mechanisms of this phenomenon. This is supported by the presence of these attacks in multiple sclerosis and tabes dorsalis, which both involve demyelination of spinal cord neurons. Exercise, tactile stimuli, hot water, anxiety and neck flexion may provoke<unk> s. Most reported<unk> s are painful tonic spasms, dysarthria and ataxia, numbness and hemiparesis. They are typically different from other transient symptoms by their brevity (lasting no more than 2 minutes), frequency (from 1–2 times/day up to a few hundred times/day), stereotyped fashion and excellent response to drugs (usually carbamazepine). Withdrawal of symptoms without any residual neurological finding is another key feature in their recognition.
Paroxysmal attack
Reflex seizure
Drop attack
Non-epileptic seizure
Reflex syncope
Panic attack
Nocturnal epilepsy
Gelastic seizure