There is a high incidence of<unk> is in AIDS patients in SE Asia; 10% of patients in Hong Kong get<unk> is as an AIDS-related illness. Cases of T.<unk>  human infections <unk> is) have also been reported in HIV-positive patients in Australia, Europe, Japan, the UK and the U.S. All the patients, except one, had visited Southeast Asia previously. The disease is considered an AIDS-defining illness. Discovered in bamboo rats (Rhizomys) in Vietnam, it is associated with these rats and the tropical Southeast Asia area.<unk>  is endemic in Myanmar (Burma), Cambodia, Southern China, Indonesia, Laos, Malaysia, Thailand and Vietnam. Although both the immunocompetent and the immunocompromised can be infected, it is extremely rare to find systemic infections in HIV-negative patients. The incidence of T.<unk>  is increasing as HIV spreads throughout Asia. An increase in global travel and migration means it will be of increased importance as an infection in AIDS sufferers.<unk>  has been found in bamboo rat faeces, liver, lungs and spleen. It has been suggested that these animals serve as a reservoir for the fungus. It is not clear whether the rats are affected by T.<unk>  or are merely asymptomatic carriers of the disease. One study of 550 AIDS patients showed that the incidence was higher during the rainy season, which is when the rats breed. But this season also has conditions that are more favorable for production of fungal spores (conidia), which can become airborne and be inhaled by susceptible individuals. Another study could not establish contact with bamboo rats as a risk factor, but exposure to the soil was the critical risk factor. However, soil samples failed to yield much of the fungus. It is not known whether people get the disease by eating infected rats, or by inhaling fungi from their faeces. One HIV-positive physician is known to have been infected while attending a course on tropical microbiology. He did not handle the organism, though students in the same laboratory did. It is presumed he contracted the infection by inhaling aerosol containing T.<unk>  conidia. This shows that airborne infections are possible.
Talaromyces marneffei
Aspergillus tubingensis
Cryptococcus neoformans
Madurella mycetomatis
Cryptococcus gattii
Paracoccidioides brasiliensis
Leptosphaeria coniothyrium
Candida parapsilosis