It comprises part of what is known as sepsis and occurs after initiation of antibacterials when treating Gram-negative infections such as Escherichia coli and louse- and tick-borne infections. It usually manifests in 1–3 hours after the first dose of antibiotics as fever, chills, rigor, hypotension, headache, tachycardia, hyperventilation, vasodilation with flushing, myalgia (muscle pain), exacerbation of skin lesions and anxiety. The intensity of the<unk>  indicates the severity of inflammation.<unk>  commonly occurs within two hours of drug administration, but is usually self-limiting.
Jarisch–Herxheimer reaction
Papular purpuric gloves and socks syndrome
Hopkins syndrome
Bowel-associated dermatosis–arthritis syndrome
Stevens–Johnson syndrome
Bogart–Bacall syndrome
Pitt–Hopkins syndrome
Swyer–James syndrome