Organophosphorus insecticides are the most widely used and are most frequently involved in fatal human poisonings. They may be absorbed through the skin, and there have been accidental poisoning cases arising from such exposure. Accidental contamination of food with insecticides is also possible. The adverse effect of<unk>  are caused by the inhibition of cholinesterases. Acute poisoning leads to uncontrollable muscle movement. Which can in severe cases lead to convulsions, respiratory depression and possible death if left untreated. An epidemiologic study on farmers which assessed their exposure from insecticides showed that farmers who applied<unk>  to animals had measurable exposures, but the levels were lower than what had been seen in other pesticide applications. Inhalation exposures were insignificant when compared with dermal exposures, which came primarily from the hands. Clothing, particularly gloves, provided substantial protection from exposures. The accumulation of acetylcholine leads to symptoms that mimic the muscarinic, nicotinic, and central nervous system actions of acetylcholine. Muscarinic signs and symptoms are tightness of the chest, bronchoconstriction, bradycardia, and constriction of the pupils. Salivation, lacrimation, and sweating are all increased, and peristalsis is also increased, leading to nausea, vomiting, and diarrhea. Nicotinic symptoms result from the accumulation of acetylcholine at motor nerve endings in skeletal muscle and ganglia. Thus, there is fatigue, involuntary twitching, and muscular weakness, which may affect the muscles of respiration. Accumulation of acetylcholine in the CNS leads to a variety of signs and symptoms, including tension, anxiety, ataxia, convulsions, restlessness, insomnia and coma.
Phosmet
Cerate
Phosphate
Selenous acid
SeHCAT
Hydrogen fluoride
Biotin
Phosphine