<unk>  dysfunction in mice can cause ineffective production of red blood cells, severe anemia, hemolysis, and death. This protein has also been shown as a requirement for heme production and in erythroid lineage,<unk>  is a major survival factor responsible for an estimated half of the total survival "signal" proerythroblasts must receive in order to survive and become red cells.<unk>  promoter contains GATA-1 and Stat5 sites. This protein accumulates throughout the differentiation, ensuring the survival of erythroid progenitors. Because iron metabolism and incorporation into hemoglobin occurs inside the mitochondria,<unk>  was suggested to play additional roles in regulating this process in erythrocytes which could lead to a role in polycythemia vera, a disease where there is an overproduction of erythrocytes. Similar to other<unk> -2 family members,<unk>  has been implicated in the survival of cancer cells by inhibiting the function of p53, a tumor suppressor. In cancerous mouse cells, those which contained<unk>  were able to survive while those that only expressed p53 died in a small period of time.<unk>  is a target of various senolytic agents. Studies of cell cultures of senescent human umbilical vein endothelial cells have shown that both fisetin and quercetin induce apoptosis by inhibition of<unk> . Fisetin has roughly twice the senolytic potency as quercetin. Small molecule<unk>  inhibitor that directly binds to<unk>  and releases their partner such as Bax, a proapoptotic protein, has been suggested as an anticancer strategy via inducing of apoptosis.
Bcl-xL
Bcl-2
IKK2
Mad2
C-Fos
STAT protein
P73
Caspase-9