<unk>  <unk>  is a group of rare, heterogeneous autoinflammatory disease characterized by interleukin 1β-mediated systemic inflammation and clinical symptoms involving skin, joints, central nervous system, and eyes. It encompasses a spectrum of three clinically overlapping autoinflammatory<unk> s including familial cold autoinflammatory<unk>  (FCAS, formerly termed familial cold-induced urticaria), the Muckle–Wells<unk>  (MWS), and neonatal-onset multisystem inflammatory disease (NOMID, also called chronic infantile neurologic cutaneous and articular<unk>  or CINCA) that were originally thought to be distinct entities, but in fact share a single genetic mutation and pathogenic pathway, and keratoendotheliitis fugax hereditaria in which the autoinflammatory symptoms affect only the anterior segment of the eye.
Cryopyrin-associated periodic syndrome
Hereditary angioedema
Antisynthetase syndrome
Mixed connective tissue disease
IgA vasculitis
TNF receptor associated periodic syndrome
Auto-brewery syndrome
Familial Mediterranean fever