<unk>  is used for the treatment of schizophrenia and bipolar disorder. In the United States,<unk>  is indicated for the treatment of: * Schizophrenia in adults and adolescents (13 to 17 years) * Depressive episode associated with bipolar I disorder in adults and pediatric patients (10 to 17 years) as monotherapy * Depressive episode associated with bipolar I disorder in adults as adjunctive therapy with lithium or valproate In the European Union,<unk>  is indicated for the treatment of schizophrenia in adults aged 18 years and over, but not for bipolar disorder. A 2014 review found<unk>  to be similar in effectiveness to other atypical antipsychotics. A 2013 review of 15 antipsychotic medications in schizophrenia found<unk>  demonstrated mild effectiveness. It is considered to be as effective as iloperidone, and 13 to 15% less effective than ziprasidone, chlorpromazine, and asenapine. In July 2013,<unk>  received approval for bipolar I depression. Few available atypical antipsychotics are known to possess antidepressant efficacy in bipolar disorder (with the notable exceptions being quetiapine, olanzapine and possibly asenapine) as a monotherapy, even though the majority of atypical antipsychotics are known to possess significant antimanic activity, which is yet to be clearly demonstrated for<unk> . In the early post approval period<unk> -treated patients with bipolar disorder were retrospectively found to have more complex clinical profiles, comorbidities, and prior treatment history compared to patients initiated with other atypical antipsychotics. The study authors suggest this may be due to "the overall clinical profile of<unk> , the role perceived for<unk>  in the therapeutic armamentarium by practitioners, and the recent introduction of<unk>  into clinical practice during the study period."<unk>  is not approved by the Food and Drug Administration (FDA) for the treatment of behavior disorders in older adults with dementia.
Lurasidone
Rimonabant
Pirfenidone
Belinostat
Pirlindole
Family therapy
Lorpiprazole
Chlortalidone