<unk>  is inherited in an X-linked dominant manner.<unk>  is lethal in most, but not all, males. A female with<unk>  may have inherited the IKBKG mutation from either parent or have a new gene mutation. Parents may either be clinically affected or have germline mosaicism. Affected women have a 50% risk of transmitting the mutant IKBKG allele at conception; however, most affected male conceptuses miscarry. Thus, the effective ratio for liveborn children from a mother carrying the mutation is 33% unaffected females, 33% affected females, and 33% unaffected males. Genetic counseling, prenatal testing, and preimplantation genetic diagnosis is available. In females, the cells expressing the mutated IKBKG gene due to lyonization selectively die around the time of birth, so the X-inactivation is extremely skewed.<unk>  is caused by mutations in a gene called NEMO (NF-κB essential modulator).
Incontinentia pigmenti
Dementia praecox
Camel spongiform encephalopathy
Autistica
Multiple evanescent white dot syndrome
Keshan disease
Familial Danish dementia
Semantic dementia