<unk>  needs to be distinguished from symptoms of the disease itself and, in the case of drugs, from other adverse effects—for example tumor lysis syndrome requires different interventions. As of 2015, differential diagnoses depended on the judgement of doctor as there were no objective tests. Classification<unk>  is a form of systemic inflammatory response syndrome and is an adverse effect of some drugs. The Common Terminology Criteria for Adverse Events classifications for<unk>  as of version 4.03 issued in 2010 were: Grades Toxicity Grade 1 Mild reaction, infusion interruption not indicated; intervention not indicated Grade 2 Therapy or infusion interruption indicated but responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics, IV fluids); prophylactic medications indicated for <=24 hrs Grade 3 Prolonged (e.g., not rapidly responsive to symptomatic medication or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae (e.g., renal impairment, pulmonary infiltrates) Grade 4 Life-threatening consequences; pressor or ventilatory support indicated Grade 5 Death
Cytokine release syndrome
Macrophage activation syndrome
Systemic inflammatory response syndrome
Activation syndrome
Mast cell activation syndrome
Multiple organ dysfunction syndrome
SUNCT syndrome
SAHA syndrome