<unk> <unk> <unk>  is caused by a deficiency of the enzyme tyrosine aminotransferase (), encoded by the gene TAT. Tyrosine aminotransferase is the first in a series of five enzymes that converts tyrosine to smaller molecules, which are excreted by the kidneys or used in reactions that produce energy. This form of the disorder can affect the eyes, skin, and mental development. Symptoms often begin in early childhood and include excessive tearing, abnormal sensitivity to light (photophobia), eye pain and redness, and painful skin lesions on the palms and soles. About half of individuals with<unk> <unk> <unk>  are also mentally challenged.<unk> <unk> <unk>  occurs in fewer than 1 in 250,000 individuals. Pathophysiology of metabolic disorders of tyrosine, resulting in elevated levels of tyrosine in blood.
Tyrosinemia type II
Hawkinsinuria
Aspartylglucosaminuria
Aldolase A deficiency
Essential fructosuria
Transaldolase deficiency
Phenylketonuria
Cystathioninuria