Neonatal<unk>  manifests itself in three forms: skin, eye, and mouth<unk>  (SEM, sometimes referred to as "localized"); disseminated<unk>  (DIS); and central nervous system<unk>  (CNS). * SEM<unk>  is characterized by external lesions but no internal organ involvement. Lesions are likely to appear on trauma sites such as the attachment site of fetal scalp electrodes, forceps, or vacuum extractors that are used during delivery; in the margin of the eyes; in the nasopharynx; and in areas associated with trauma or surgery (including circumcision). * DIS<unk>  affects internal organs, particularly the liver. * CNS<unk>  is an infection of the nervous system and the brain that can lead to encephalitis. Infants with CNS<unk>  present with seizures, tremors, lethargy, and irritability. They feed poorly, have unstable temperatures, and their fontanelle (soft spot of the skull) may bulge. CNS<unk>  is associated with higher morbidity, while DIS<unk>  has a higher mortality rate. These categories are not mutually exclusive and there is often overlap of two or more types. SEM<unk>  has the best prognosis of the three, however if left untreated it may progress to disseminated or CNS<unk>  with attendant increases in mortality and morbidity. Death from neonatal HSV disease in the U.S. is currently decreasing; the current death rate is about 25%, down from as high as 85% in untreated cases just a few decades ago. Other complications from neonatal<unk>  include prematurity, with approximately 50% of cases having a gestation of 38 weeks or less, and concurrent sepsis in approximately one-quarter of cases that further clouds speedy diagnosis.
Neonatal herpes simplex
Neonatal tetanus
Congenital syphilis
Neonatal lupus erythematosus
Neonatal conjunctivitis
Congenital cutaneous candidiasis
Mumps
Neonatal meningitis