After oral administration, 20 mg of<unk>  are resorbed quickly and reach the peak plasma concentration of 3 mg/l within an hour. The diuretic effect starts about an hour after administration, reaches its peak between the third and sixth hour, and lasts for nearly 24 hours. One third of the dose is glucuronidized, the rest is excreted directly through the kidney (1/3) and the faeces (2/3). The total plasma clearance is 30-40 ml/min.<unk>  can be filtrated by haemodialysis but not by peritoneal dialysis.
Xipamide
Lumasiran
Fabomotizole
Brotizolam
Caroxazone
Seltorexant
Nicorandil
Mitapivat