Inflammatory cells and red blood cells<unk> s <unk> s) are a class of proteins whose concentrations in blood plasma either increase (positive<unk> s) or decrease (negative<unk> s) in response to inflammation. This response is called the<unk><unk>  reaction (also called<unk><unk>  response). The<unk><unk>  reaction characteristically involves fever, acceleration of peripheral leukocytes, circulating neutrophils and their precursors. The terms<unk>  and<unk><unk>  reactant (APR) are often used synonymously, although some APRs are (strictly speaking) polypeptides rather than proteins. In response to injury, local inflammatory cells (neutrophil granulocytes and macrophages) secrete a number of cytokines into the bloodstream, most notable of which are the interleukins IL1, and IL6, and TNF-α. The liver responds by producing many<unk><unk>  reactants. At the same time, the production of a number of other proteins is reduced; these proteins are, therefore, referred to as "negative"<unk><unk>  reactants. Increased<unk> s from the liver may also contribute to the promotion of sepsis.
Acute-phase protein
Inflammatory cytokine
Microantibody
Cytokine
Lipoprotein
Coagulation activation marker
Lymphokine
Antibody