Mechanism of action<unk>  reversibly binds to the active site on the thrombin molecule, preventing thrombin-mediated activation of coagulation factors. Furthermore,<unk>  can inactivate thrombin even when thrombin is fibrin-bound; it reduces thrombin-mediated inhibition of fibrinolysis and, therefore, may enhance fibrinolysis. Pharmacokinetics<unk>  has a half-life of approximately 12–14 h and exerts a maximum anticoagulation effect within 2–3 hours after ingestion. Fatty foods delay the intestinal absorption of<unk> , although the bioavailability of the drug is unaffected. One study showed that absorption may be moderately decreased if taken with a proton pump inhibitor.<unk>  excretion through P-glycoprotein pumps is slowed in patients taking strong p-glycoprotein pump inhibitors such as quinidine, verapamil, and amiodarone, thus raising plasma levels of<unk> .<unk>  is formulated as the prodrug<unk>  etexilate.
Dabigatran
Apixaban
Enoxaparin sodium
Rivaroxaban
Palladin
Ticlopidine
Ticagrelor
Eptifibatide