<unk>  is used primarily for the treatment of depression, general anxiety disorder, social phobia, panic disorder, and vasomotor symptoms.<unk>  is an antidepressant agent that can safely be used in patients with stroke history.<unk>  has been used off label for the treatment of diabetic neuropathy and migraine prevention (in some people, however,<unk>  can exacerbate or cause migraines). It may work on pain via effects on the opioid receptor. It has also been found to reduce the severity of 'hot flashes' in menopausal women and men on hormonal therapy for the treatment of prostate cancer. Due to its action on both the serotoninergic and adrenergic systems,<unk>  is also used as a treatment to reduce episodes of cataplexy, a form of muscle weakness, in patients with the sleep disorder narcolepsy. Some open-label and three double-blind studies have suggested the efficacy of<unk>  in the treatment of attention deficit-hyperactivity disorder (ADHD). Clinical trials have found possible efficacy in those with post-traumatic stress disorder (PTSD). Case reports, open trials and blinded comparisons with established medications have suggested the efficacy of<unk>  in the treatment of obsessive–compulsive disorder. Depression A comparative meta-analysis of 21 major antidepressants found that<unk> , agomelatine, amitriptyline, escitalopram, mirtazapine, paroxetine, and vortioxetine were more effective than other antidepressants, although the quality of many comparisons was assessed as low or very low.<unk>  was similar in efficacy to the atypical antidepressant bupropion; however, the remission rate was lower for<unk> . In a double-blind study, patients who did not respond to an SSRI were switched to either<unk>  or another SSRI (citalopram); similar improvement was observed in both groups. Studies have not established its efficacy for use by children. Studies have shown that the extended release is superior to the immediate release form of<unk> . A meta-analysis has shown that efficacity of<unk>  is not correlated with baseline severity of depression. Dosage<unk>  has been shown to have an optimal efficacity and tolerability towards the lower end of their licensed dose range.
Venlafaxine
Desvenlafaxine
Nortriptyline
Atomoxetine
Fluoxetine
Amitriptyline
Citalopram
Imipramine