Medical usage<unk>  is recommended as an alternative drug for treating hypertension by the JNC 8. A 2016 Cochrane review found<unk>  to be as effective as other first-line antihypertensive drugs for lowering of blood pressure. The<unk>  - thiazide diuretic combination is one of the few drug treatments shown to reduce mortality in randomized controlled trials: The Hypertension Detection and Follow-up Program, the Veterans Administration Cooperative Study Group in Anti-hypertensive Agents, and the Systolic Hypertension in the Elderly Program. Moreover,<unk>  was included as a secondary antihypertensive option for patients who did not achieve blood pressure lowering targets in the ALLHAT study. It was previously used to treat symptoms of dyskinesia in patients suffering from Huntington's disease, but alternative medications are preferred today. The daily dose of<unk>  in antihypertensive treatment is as low as 0.05 to 0.25 mg. The use of<unk>  as an antipsychotic drug had been nearly completely abandoned, but more recently it made a comeback as adjunctive treatment, in combination with other antipsychotics, so that more refractory patients get dopamine blockade from the other antipsychotic, and dopamine depletion from<unk> . Doses for this kind of adjunctive goal can be kept low,<unk> ulting in better tolerability. Originally, doses of 0.5 mg to 40 mg daily were used to treat psychotic diseases. Doses in excess of 3 mg daily often required use of an anticholinergic drug to combat excessive cholinergic activity in many parts of the body as well as parkinsonism. For adjunctive treatment, doses are typically kept at or below 0.25 mg twice a day. Veterinary<unk>  is used as a long-acting tranquilizer to subdue excitable or difficult horses and has been used illicitly for the sedation of show horses, for-sale horses, and in other circumstances where a "quieter" horse might be desired. Antibacterial effects<unk>  inhibits formation of biofilms by Staphylococcus aureus and inhibits the metabolic activity of bacteria present in biofilms.
Reserpine
Meptazinol
Rivastigmine
Tianeptine
Fluorodopa
Butriptyline
Promazine
Complanine