In the fields of molecular biology and genetics,<unk>  is a proto-oncogene that is the human homolog of the retroviral oncogene<unk> . It was first discovered in rat fibroblasts as the transforming gene of the FBJ MSV (Finkel–Biskis–Jinkins murine osteogenic sarcoma virus) <unk> urran and Tech, 1982). It is a part of a bigger<unk>  family of transcription factors which includes<unk> ,<unk> B, Fra-1 and Fra-2. It has been mapped to<unk> hromosome region 14q21→q31.<unk>  encodes a 62 kDa protein, which forms heterodimer with<unk> -jun (part of Jun family of transcription factors), resulting in the formation of AP-1 (Activator Protein-1)<unk> omplex which binds DNA at AP-1 specific sites at the promoter and enhancer regions of target genes and<unk> onverts extracellular signals into<unk> hanges of gene expression. It plays an important role in many<unk> ellular functions and has been found to be overexpressed in a variety of<unk> ancers.
C-Fos
Orf 
Bcl-2
BIM-1
AP-7 
HER2/neu
COVAX-19
Mad2