Mechanism of action Like tafluprost and travoprost,<unk>  is an ester prodrug that is activated to the free acid in the cornea. Also like the related drugs,<unk>  acid is an analog of prostaglandin F2α that acts as a selective agonist at the prostaglandin F receptor. Prostaglandins increase the sclera's permeability to aqueous fluid. So, an increase in prostaglandin activity increases outflow of aqueous fluid thus lowering intraocular pressure. Pharmacokinetics<unk>  is absorbed well through the cornea and completely hydrolysed to the active<unk>  acid. Highest concentrations of the acid in the aqueous humour are reached two hours after application, lowering of intraocular pressure starts after 3 to 4 hours, the highest effect is found after 8 to 12 hours, and its action lasts at least 24 hours. When<unk>  acid reaches the circulation, it is quickly metabolised in the liver by beta oxidation to 1,2-dinor- and 1,2,3,4-tetranor-latanoprost acid; blood plasma half life is only 17 minutes. The metabolites are mainly excreted via the kidney. The activation and deactivation pathway is analogous to the one of tafluprost (at least up to the tetranor-metabolite); compare Tafluprost#Pharmacokinetics. Metabolism. From left to right:<unk> ,<unk>  acid (the active metabolite), 1,2-dinorlatanoprost acid, 1,2,3,4-tetranorlatanoprost acid
Latanoprost
Travoprost
Carboprost
Iloprost
Bimatoprost
Travoprost/timolol
Bimatoprost/timolol
Bifluranol