Common sites of metastasis for breast<unk> <unk> , also referred to as metastases, advanced breast<unk> , secondary tumors, secondaries or stage IV breast<unk> , is a stage of breast<unk>  where the breast<unk>  cells have spread to distant sites beyond the axillary lymph nodes. There is no cure for<unk> ; There is no stage after IV. Metastases can occur several years after the primary breast<unk> , although it is sometimes diagnosed at the same time as the primary breast<unk>  or, rarely, before the primary breast<unk>  has been diagnosed.<unk>  cells frequently differ from the preceding primary breast<unk>  in properties such as receptor status. The cells have often developed resistance to several lines of previous treatment and have acquired special properties that permit them to metastasize to distant sites.<unk>  can be treated, sometimes for many years, but it cannot be cured. Distant metastases are the cause of about 90% of deaths due to breast<unk> . Breast<unk>  can metastasize anywhere in body but primarily metastasizes to the bone, lungs, regional lymph nodes, liver and brain, with the most common site being the bone. Treatment of<unk>  depends on location of the<unk>  tumors and includes surgery, radiation, chemotherapy, biological, and hormonal therapy. Typical environmental barriers in a<unk>  event include physical (a basement membrane), chemical (reactive oxygen species or ROS, hypoxia and low pH) and biological (immune surveillance, inhibitory cytokines and regulatory extra-cellular matrix (ECM) peptides) components. Organ-specific anatomic considerations also influence metastasis; these include blood-flow patterns from the primary tumor and the homing ability of<unk>  cells to certain tissues. The targeting by<unk>  cells of specific organs is probably regulated by chemo-attractant factors and adhesion molecules produced by the target organ, along with cell-surface receptors expressed by the tumor cells.
Metastatic breast cancer
Metastatic carcinoma
Cancer of unknown primary origin
Medullary carcinoma
Acinar cell carcinoma of the pancreas
Adrenocortical carcinoma
Hormone receptor positive breast tumor
Parathyroid carcinoma