<unk>  protein consists of six domains: A1-A2-B-A3-C1-C2, and is homologous to<unk>  V. The A domains are homologous to the A domains of the copper-binding protein ceruloplasmin. The C domains belong to the phospholipid-binding discoidin domain family, and the C2 domain mediate membrane binding. Activation of<unk>  to<unk> a is done by cleavage and release of the B domain. The protein is now divided to a heavy chain, consisting of the A1-A2 domains, and a light chain, consisting of the A3-C1-C2 domains. Both form non-covalently a complex in a calcium-dependent manner. This complex is the pro-coagulant<unk> a.
Factor VIII
Factor IX
Factor XI
Thrombin
Prothrombinase
Von Willebrand factor
Fibrinogen
Platelet-activating factor