<unk>  <unk>  is a type of cancer that can form masses in the skin, in lymph nodes, in the mouth, or in other organs. The skin lesions are usually painless, purple and may be flat or raised. Lesions can occur singly, multiply in a limited area, or may be widespread. Depending on the sub-type of disease and level of immune suppression,<unk>  may worsen either gradually or quickly.<unk>  is caused by a combination of immune suppression (such as due to HIV/AIDS) and infection by Human herpesvirus 8 (HHV8 – also called<unk> -associated herpesvirus <unk> HV)). Four sub-types are described: classic, endemic, immunosuppression therapy-related (also called iatrogenic), and epidemic (also called AIDS-related). Classic<unk>  tends to affect older men in regions where<unk> HV is highly prevalent (Mediterranean, Eastern Europe, Middle East), is usually slow-growing, and most often affects only the legs. Endemic<unk>  is most common in Sub-Saharan Africa and is more aggressive in children, while older adults present similarly to classic<unk> . Immunosuppression therapy-related<unk>  generally occurs in people following organ transplantation and mostly affects the skin. Epidemic<unk>  occurs in people with AIDS and many parts of the body can be affected.<unk>  is diagnosed by tissue biopsy, while the extent of disease may be determined by medical imaging. Treatment is based on the sub-type, whether the condition is localized or widespread, and the person's immune function. Localized skin lesions may be treated by surgery, injections of chemotherapy into the lesion, or radiation therapy. Widespread disease may be treated with chemotherapy or biologic therapy. In those with HIV/AIDS, highly active antiretroviral therapy (HAART) prevents and often treats<unk> . In certain cases the addition of chemotherapy may be required. With widespread disease, death may occur. The condition is relatively common in people with HIV/AIDS and following organ transplant. Over 35% of people with AIDS may be affected.<unk>  was first described by Moritz<unk>  in 1872. It became more widely known as one of the AIDS-defining illnesses in the 1980s.<unk> HV was discovered as a causative agent in 1994.
Kaposi's sarcoma
Melanoma
Mule spinners' cancer
Melanocytic nevus
Ewing's sarcoma
Blue rubber bleb nevus syndrome
Lymphangiosarcoma
Pyogenic granuloma