Currently, clinical diagnosis of CMM<unk>  has been based on clinical findings or molecular genetic testing. Clinical Findings (Signs and Symptoms): * onset of<unk><unk> s in infancy or early childhood * persistence of<unk><unk> s into and throughout adulthood with the absence of other neurologic<unk> s * little improvement nor deterioration of<unk><unk> s over the course of one’s life * intensity of<unk> ed<unk> s increasing with the complexity of the voluntary<unk>  * involuntary<unk><unk> s that are generally of lesser amplitude compared with voluntary<unk> s * predominant<unk><unk>  in upper limbs, with increasing severity in more distal appendages (fingers) * inability to perform tasks requiring skilled bimanual coordination * occasional pain in the upper limbs during prolonged manual activities * occasional observed subclinical<unk> ing<unk> , but detectable with accelerometer gloves Molecular genetic testing: * identification of a heterozygous mutant DCC, DNAL4, or RAD51 gene (single gene test or multi-gene panel)
Congenital mirror movement disorder
Athetoid cerebral palsy
Ataxic cerebral palsy
Cerebral achromatopsia
Dorian Gray syndrome
Non-progressive congenital ataxia
Paramyotonia congenita
Acrocallosal syndrome