Mechanism of action The substance blocks NS5A, a protein necessary for hepatitis C virus replication and assembly. Pharmacokinetics<unk>  reaches highest blood plasma levels three hours after oral intake together with sofosbuvir. Plasma protein binding is over 99.5%. It is slowly metabolised by the liver enzymes CYP2B6, CYP2C8 and CYP3A4. While monohydroxylated and demethylated metabolites have been identified in human blood plasma and faeces, over 98% of the circulating substance is<unk>  itself. 94% are excreted via the faeces, and only 0.4% via the urine. Biological half-life is about 15 hours.
Velpatasvir
Ledipasvir
Ombitasvir
Odalasvir
Telaprevir
Elbasvir
Fostemsavir
Saquinavir