<unk>  is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. While these symptoms may indicate<unk> , they<unk> n also have other<unk> uses. Over 100 types of<unk> s affect humans. Tobacco use is the<unk> use of about 22% of<unk>  deaths. Another 10% are due to obesity, poor diet, lack of physical activity or excessive drinking of alcohol. Other factors include certain infections, exposure to ionizing radiation, and environmental pollutants. In the developing world, 15% of<unk> s are due to infections such as Helicobacter pylori, hepatitis B, hepatitis C, human papillomavirus infection, Epstein–Barr virus and human immunodeficiency virus (HIV). These factors act, at least partly, by changing the genes of a cell. Typically, many genetic changes are required before<unk>  develops. Approximately 5–10% of<unk> s are due to inherited genetic defects.<unk> <unk> n be detected by certain signs and symptoms or screening tests. It is then typically further investigated by medical imaging and confirmed by biopsy. The risk of developing certain<unk> s<unk> n be reduced by not smoking, maintaining a healthy weight, limiting alcohol intake, eating plenty of vegetables, fruits, and whole grains, vaccination against certain infectious diseases, limiting consumption of processed meat and red meat, and limiting exposure to direct sunlight. Early detection through screening is useful for cervical and colorectal<unk> . The benefits of screening for breast<unk>  are controversial.<unk>  is often treated with some combination of radiation therapy, surgery, chemotherapy and targeted therapy. Pain and symptom management are an important part of<unk> re. Palliative<unk> re is particularly important in people with advanced disease. The chance of survival depends on the type of<unk>  and extent of disease at the start of treatment. In children under 15 at diagnosis, the five-year survival rate in the developed world is on average 80%. For<unk>  in the United States, the average five-year survival rate is 66%. In 2015, about 90.5 million people worldwide had<unk> . In 2019, annual<unk> <unk> ses grew to 23.6 million people and 10 million deaths worldwide, representing over the previous decade increases of 26% and 21%, respectively. The most common types of<unk>  in males are lung<unk> , prostate<unk> , colorectal<unk> , and stomach<unk> . In females, the most common types are breast<unk> , colorectal<unk> , lung<unk> , and cervical<unk> . If skin<unk>  other than melanoma were included in total new<unk> <unk> ses each year, it would account for around 40% of<unk> ses. In children, acute lymphoblastic leukemia and brain tumors are most common, except in Africa, where non-Hodgkin lymphoma occurs more often. In 2012, about 165,000 children under 15 years of age were diagnosed with<unk> . The risk of<unk>  increases significantly with age, and many<unk> s occur more commonly in developed countries. Rates are increasing as more people live to an old age and as lifestyle changes occur in the developing world. The financial costs of<unk>  were estimated at 1.16 trillion USD per year . script)
Cancer
Anorexia nervosa
Disease
Heartburn
Cardiovascular disease
Vaginitis
Skin cancer
Neuropathic pain