<unk>  is a cytolytic 31-amino acid α-helical amphipathic peptide toxin secreted by the opportunistic pathogen Candida albicans. This toxin is a fungal example of a classical virulence factor. Hyphal morphogenesis in C. albicans is associated with damage to host epithelial cells; during this process<unk>  is released and intercalates in host membranes.<unk>  promotes damage of oral epithelial cells and induces lactate dehydrogenase release and calcium ion influx. It is unique in the fact that it is the first peptide toxin to be identified in any human fungal pathogen.<unk>  is a product of the larger protein Ece1 (extent of cell elongation 1). Sequential processing of Ece1 at lysine/arginine residues by the proteases Kex2 and Kex1 releases several peptides, including the toxin<unk> . Consequently,<unk>  is also known as Ece1-III62–92K. C. albicans strains missing<unk>  do not damage epithelial cells and are said to be avirulent with respect to mucosal infections. The toxin is also responsible for the activation and propagation of a cellular immune response.
Candidalysin
Babycurus toxin 1
Proscillaridin
Simmondsin
Diamphotoxin
Dermatoxin
Jingzhaotoxin
Grammotoxin