MRI scan showing the characteristic smooth brain of an individual with<unk>  Affected children display severe psychomotor impairment, failure to thrive, seizures, and muscle spasticity or hypotonia. Other symptoms of the disorder may include unusual facial appearance, difficulty swallowing, and anomalies of the hands, fingers, or toes. Symptoms of<unk>  are detected via ultrasound at about twenty-three weeks and require confirmation from a prenatal MRI. It is characterised by absence or reduction of the sulci and gyri of the cerebral surface and a thickened cortex. There are anatomical symptoms that differ across the two main types of<unk> , Classical (Type I) and Cobble Stone (Type 2). In Classical<unk>  the cortex becomes thickened and can be identified by four layers of the cerebral cortex rather than six. Cobblestone<unk>  is named after the pebbled or cobblestone appearance of the cortical surface. This uneven cortical surface is due to incomplete organogenesis which leads to no distinguishable layers in the cerebral cortex. Cobblestone<unk>  shows a reduction and abnormalities in the grey matter of the cerebral cortex.
Lissencephaly
Schizencephaly
Holoprosencephaly
Hemihydranencephaly
Microlissencephaly
Hydranencephaly
Microhydranencephaly
Megalencephaly