The prevailing theory for the development of<unk>  is thought to be the interplay of genetic predisposition, an environmental trigger (virus, drugs, herbs, immunizations), and failure of the native immune system resulting in chronic inflammation of hepatocytes and subsequent fibrosis of the liver. There is no specific evidence of the cause. Sixty percent of patients have findings associated with chronic hepatitis but without serologic evidence of a viral infection. The disease is strongly associated with anti-smooth muscle autoantibodies. The exact genes and triggers responsible remain undefined, but studies show association of early-onset, severe disease with the HLA-DR3 serotype and late-onset disease with the HLA-DR4 serotype.
Autoimmune hepatitis
Primary biliary cholangitis
Viral hepatitis
Primary sclerosing cholangitis
Alcoholic hepatitis
Ischemic hepatitis
Alcoholic liver disease
Idiopathic granulomatous hepatitis