Pharmacokinetics The elimination half-lives of clinically used<unk>  receptor antagonists are 12 hours for suvorexant, about 17 to 19 hours ("effective" half-life) or 55 hours (terminal elimination half-life) for lemborexant, and 6 to 10 hours for daridorexant. The elimination half-lives of investigational<unk>  receptor antagonists are 2 to 3 hours for seltorexant and about 1.5 to 3 hours for vornorexant.
Orexin antagonist
Steroidogenesis inhibitor
Dopamine agonist
Dopamine antagonist
Antiglucocorticoid
Neurosteroidogenesis inhibitor
Nerve growth factor inhibitor
Alpha-adrenergic agonist