Early signs and symptoms of the disorder usually appear around ages 2–10, with gradual onset of vision problems or seizures. Early signs may be subtle personality and behavioral changes, slow learning or regression, repetitive speech or echolalia, clumsiness or stumbling. Slowing head growth in the infantile form, poor circulation in lower extremities (legs and feet), decreased body fat and muscle mass, curvature of the spine, hyperventilation and/or breath-holding spells, teeth grinding and constipation may occur. Over time, affected children suffer mental impairment, worsening seizures and progressive loss of sight, speech and motor skills.<unk>  is a terminal disease; life expectancy varies depending on the type or variation. Females with juvenile<unk>  show first symptoms a year later than males, but on average die a year sooner.
Batten disease
Keshan disease
Akureyri disease
Krabbe disease
Farber disease
Karak syndrome
Sandhoff disease
Menkes disease