Improper administration of an<unk>  can cause electrolyte imbalance (with repeated<unk> s) or ruptures to the bowel or rectal tissues resulting in internal bleeding. However, these occurrences are rare in healthy, sober adults. Internal bleeding or rupture may leave the individual exposed to infections from intestinal bacteria. Blood resulting from tears in the colon may not always be visible, but can be distinguished if the feces are unusually dark or have a red hue. If intestinal rupture is suspected, medical assistance should be obtained immediately. Frequent use of<unk> s can cause laxative dependency. The<unk>  tube and solution may stimulate the vagus nerve, which may trigger an arrhythmia such as bradycardia.<unk> s should not be used if there is an undiagnosed abdominal pain since the peristalsis of the bowel can cause an inflamed appendix to rupture. There are arguments both for and against colonic irrigation in people with diverticulitis, ulcerative colitis, Crohn's disease, severe or internal hemorrhoids or tumors in the rectum or colon, and its usage is not recommended soon after bowel surgery (unless directed by one's health care provider). Regular treatments should be avoided by people with heart disease or kidney failure. Colonics are inappropriate for people with bowel, rectal or anal pathologies where the pathology contributes to the risk of bowel perforation. Recent research has shown that ozone water, which is sometimes used in<unk> s, can immediately cause microscopic colitis. A recent case series of 11 patients with five deaths illustrated the danger of phosphate<unk> s in high-risk patients.
Enema
Granulation
Calculus 
Steatosis
Moist desquamation
Thrombus
Sclerosis 
Granulation tissue