<unk>  has been shown to selectively inhibit the persistent sodium current of Nav1.5 exerting cardioprotective effects following ischemia. In vitro testing showed minimal effects of<unk>  on other important ion channels of the heart, including major Ca2+ and K+ channels. This characteristic is thought to account for the limited effect of<unk>  to change other heart parameters such as basal cardiac function, hemodynamic functions and ventricular fibrillation.<unk>  was also shown to exert improved effects when the membrane potential was depolarized, by acting on the extracellular side of the channel. This effect of the<unk>  on the depolarised state of the persistent sodium current renders the drug particularly useful in ischemic conditions when the cardiac cell is depolarised.
F15845
714-X
DCW234
RUB A535
LY3372689
McN5652
Lq2
ABTL0812