Micrograph showing extreme<unk>  in cancer (glioblastoma). Brain biopsy. HPS stain.<unk>  refers to abnormal appearance of cell nuclei. It is a term used in cytopathology and histopathology.<unk> al nuclei are often pleomorphic.<unk>  can be seen in reactive changes, pre-neoplastic changes and malignancy. Severe<unk>  is, in most cases, considered an indicator of malignancy.
Nuclear atypia
Tumor budding
Pleomorphism 
Hyperkeratinization
Zoobiquity
Nuclear sclerosis
Lobulation
Perineural invasion