GABA and<unk>  are coloured magenta. Subunits in different colours. One alpha and one beta subunit is hidden. Green chloride ions illustrated in the channel pore. Pharmacodynamics (R)-Etomidate is tenfold more potent than its (S)-enantiomer. At low concentrations (R)-etomidate is a modulator at GABAA receptors containing β2 and β3 subunits. At higher concentrations, it can elicit currents in the absence of GABA and behaves as an allosteric agonist. Its binding site is located in the transmembrane section of this receptor between the beta and alpha subunits (β+α−). β3-containing GABAA receptors are involved in the anesthetic actions of<unk> , while the β2-containing receptors are involved in some of the sedation and other actions that can be elicited by this drug. Pharmacokinetics At the typical dose, anesthesia is induced for the duration of about 5–10 minutes, though the half-life of drug metabolism is about 75 minutes, because<unk>  is redistributed from the plasma to other tissues. * Onset of action: 30–60 seconds * Peak effect: 1 minute * Duration: 3–5 minutes; terminated by redistribution * Distribution: Vd: 2–4.5 L/kg * Protein binding: 76% * Metabolism: Hepatic and plasma esterases * Half-life distribution: 2.7 minutes * Half-life redistribution: 29 minutes * Half-life elimination: 2.9 to 5.3 hours
Etomidate
Metharbital
Sevoflurane
Esketamine
Remifentanil
Ketamine
Propofol
Methoxyflurane