<unk> s are compounds that slow or stop the action of the<unk> <unk><unk>  <unk><unk>  or<unk> -LOX) enzyme, which is responsible for the production of inflammatory leukotrienes. The overproduction of leukotrienes is a major cause of inflammation in asthma, allergic rhinitis, and osteoarthritis. Examples of<unk> -LOX inhibitors include the pharmaceutical drugs meclofenamate sodium, zileuton and the natural products myxochelins/pseudochelin as well as nordihydroguaiaretic acid (NDGA). Some chemicals found in trace amounts in food, as well as some dietary supplements, have been shown to inhibit<unk> -LOX; these include baicalein, caffeic acid, curcumin, hyperforin and St John's wort. acetyl-keto-beta-boswellic acid (AKBA), one of the bioactive boswellic acids found in Boswellia serrata (Indian Frankincense) has been found to inhibit<unk><unk>  strongly as an allosteric inhibitor. Boswellia administration has been shown to reduce brain edema in patients irradiated for brain tumor and it's believed to be due to<unk><unk>  inhibition.
Arachidonate 5-lipoxygenase inhibitor
COX-2 inhibitor
TNF inhibitor
CCR5 receptor antagonist
Lipase inhibitors
Tissue factor pathway inhibitor
Endopeptidase inhibitor
Carbonic anhydrase inhibitor