File:Micrograph of<unk> .Micrograph of<unk> . Subepidermal blistering solid arrows in (A,B) and influx of inflammatory cells including eosinophils and neutrophils in thedermis solid arrow (C) and blister cavity dashed arrows (C). In (C) also deposition of fibrin is noted (asterisks). Diagnosis consist of at least 2 positive results out of 3 criteria (2-out-of-3 rule): (1) pruritus and/or predominant cutaneous blisters, (2) linear IgG and/or C3c deposits (in an n- serrated pattern) by direct immunofluorescence microscopy (DIF) on a skin biopsy specimen, and (3) positive epidermal side staining by indirect immunofluorescence microscopy on human salt-split skin (IIF SSS) on a serum sample. Routine H&E staining or ELISA tests do not add value to initial diagnosis.
Bullous pemphigoid
Epidermolysis bullosa
Mucous membrane pemphigoid
Vesicular pemphigoid
IgA pemphigus
Paraneoplastic pemphigus
Pemphigoid nodularis
Giant cell lichenoid dermatitis