<unk>  (PPAP) is an autosomal dominant hereditary cancer syndrome, which is characterized by numerous polyps in the colon and an increased risk of colorectal cancer. It is caused by germline mutations in DNA<unk>  ε (POLE) and δ (POLD1). Affected individuals develop numerous polyps called colorectal adenomas. Compared with other polyposis syndromes,<unk>  is rare. Genetic testing can help exclude similar syndromes, such as Familial adenomatous polyposis and MUTYH-associated polyposis. Endometrial cancer, duodenal polyps and duodenal cancer may also occur.
Polymerase proofreading-associated polyposis
MUTYH-associated polyposis
Attenuated familial adenomatous polyposis
Mismatch repair cancer syndrome
Nijmegen breakage syndrome
Hereditary nonpolyposis colorectal cancer
Serrated polyposis syndrome
Familial adenomatous polyposis