<unk>  is a substrate for CYP1A2, and interacts with many substances through this and other mechanisms. Alcohol According to DSST, alcohol provides a reduction in performance and<unk>  has a significant improvement in performance. When alcohol and<unk>  are consumed jointly, the effects produced by<unk>  are affected, but the alcohol effects remain the same. For example, when additional<unk>  is added, the drug effect produced by alcohol is not reduced. However, the jitteriness and alertness given by<unk>  is decreased when additional alcohol is consumed. Alcohol consumption alone reduces both inhibitory and activational aspects of behavioral control.<unk>  antagonizes the activational aspect of behavioral control, but has no effect on the inhibitory behavioral control. The Dietary Guidelines for Americans recommend avoidance of concomitant consumption of alcohol and<unk> , as this may lead to increased alcohol consumption, with a higher risk of alcohol-associated injury. Tobacco Smoking tobacco increases<unk>  clearance by 56%. Cigarette smoking induces the cytochrome P450 1A2 enzyme that breaks down<unk> , which may lead to increased<unk>  tolerance and coffee consumption for regular smokers. Birth control Birth control pills<unk> n extend the half-life of<unk> , requiring greater attention to<unk>  consumption. Medications<unk>  sometimes increases the effectiveness of some medications, such as those for headaches.<unk>  was determined to increase the potency of some over-the-counter analgesic medications by 40%. The pharmacological effects of adenosine may be blunted in individuals taking large quantities of methylxanthines like<unk> . Some other examples of methylxanthines include the medications theophylline and aminophylline, which are prescribed to relieve symptoms of asthma or COPD.
Caffeine
Methacholine
Betahistine
Nicotine
Phenylpropanolamine
Molsidomine
Piperoxan
Codeine