Histopathology of features often seen in basal-like breast cancer: Low magnification at left shows large geographic necroses (pink homogenous areas), and high magnification at right shows highly pleomorphic nuclei and ample mitoses. H&E stain. The<unk>  is a recently proposed subtype of breast cancer defined by its gene expression and protein expression profile. Since Preou et al. divided breast invasive carcinoma into 4 subtypes, Kapp et al. further compared multiple sets of cDNA microarray datasets, dividing breast cancer into five molecular subtypes, including luminal subtype A, luminal subtype B, normal breast-like subtype, HER-2 overexpression subtype) and basal-like Subtype. This marks the modern clinical pathological diagnosis of breast cancer has transferred from simple morphological diagnosis into morphological and molecular features combined diagnosis. Genotyping fundamentally changes the concept of breast cancer and provides breast cancer patients with more improved prognosis and treatment. In all molecular subtypes, basal-like breast cancer (BLBC) is still the biggest challenge in current research due to its strong invasiveness and molecular biological characteristics.
Basal-like carcinoma
Lymphoepithelioma-like carcinoma
Basal-cell carcinoma
Adenosquamous carcinoma
Verrucous carcinoma
Anaplastic carcinoma
Epithelioma
Spindle cell carcinoma