• Typically affects short sighted (myopic) women. (90% of cases are female). • The average age of patients with PIC is 27 years with a range of 16–40 years. • Patients are otherwise healthy and there is usually no illness, which triggers the condition or precedes it. • The inflammation is confined to the back of the eye (posterior). There is no inflammation in the front of the eye (anterior chamber) or vitreous (the clear jelly inside the eye). This is an important distinguishing feature of PIC. • It usually affects both eyes. • The appearance of gray-white or yellow<unk>  (punched out) areas (lesions) at the level of the<unk>  choroid. These lesions are typically located centrally at the back of the eye (posterior pole). Symptoms typically include: # Blurring of vision # Partial ‘blind spots’ or scotoma. These areas of diminished or lost areas of the visual field are typically near the centre of vision but occasionally can be peripheral. These may be temporary or permanent. # Seeing flashing lights. This is known as photopsia. The PIC lesions, which form scars deep in the choroid layer of the eye, may result in new blood vessels forming. These can be seen as the body’s attempts at repair, but these new blood vessels (neovascularisation) are weak, can spread to form a membrane and can threaten the vision. It is suspected that at least 40% of patients with PIC develop CNV (choroidal neovascularization). This is a complication, which can occur in other white dot syndromes and other eye conditions such as macular degeneration but occurs rarely in other forms of uveitis. CNV is a sight threatening complication and so must be picked up early and always treated. It may occur whether the uveitis is active or not. CNV, if not treated, may lead to subretinal fibrosis (scarring), a further complication, which is more difficult to treat, and which leads to poor vision. Good monitoring for patients with PIC is therefore very important.
Punctate inner choroiditis
Arteritic anterior ischemic optic neuropathy
Chronic relapsing inflammatory optic neuropathy
Posterior ischemic optic neuropathy
Toxic and nutritional optic neuropathy
Retinal vasculitis
Autoimmune optic neuropathy
Acute retinal necrosis