The vast majority of those with<unk>  require no treatment whatsoever. They have a mildly increased risk of developing gallstones, which is treated surgically with a cholecystectomy if pain becomes problematic. This risk is relative to the severity of the disease. Folate helps to reduce the extent of haemolysis in those with significant haemolysis due to<unk> . Because the spleen breaks down old and worn-out blood cells, those individuals with more severe forms of<unk>  can have splenomegaly. Symptoms of splenomegaly can include: * Vague, poorly localised abdominal pain * Fatigue and dyspnoea * Growth failure * Leg ulcers * Gallstones. Removal of the spleen (splenectomy) is effective in reducing the severity of these complications, but is associated with an increased risk of overwhelming bacterial septicaemia, and is only performed on those with significant complications. Because many neonates with severe<unk>  progress to have only a mild disease, and because this age group is particularly susceptible to pneumococcal infections, a splenectomy is only performed on those under 5 years old when it is absolutely necessary.
Hereditary elliptocytosis
Diamond–Blackfan anemia
Hereditary spherocytosis
Thiamine responsive megaloblastic anemia syndrome
Myomatous erythrocytosis syndrome
Refractory anemia with excess of blasts
Refractory anemia with ring sideroblasts
Macroglobulinemia