<unk>  (former NASDAQ symbol: MEDX ) was an American biopharmaceutical company based in Princeton, New Jersey, with manufacturing facilities in Bloomsbury and Annandale, New Jersey, and research facilities in Milpitas and Sunnyvale, California. In 2009,<unk>  was purchased by Bristol Myers Squibb.<unk>  developed monoclonal antibodies to CTLA-4 and PD-1, which are proteins on the surface of T cells. T cells attack cancer cells, but CTLA-4 and PD-1 act as "brakes" on the T cell's anti-cancer activities. The monoclonal antibodies bind to these proteins and block them, releasing the T cell to attack cancer cells. Several monoclonal antibodies developed by<unk>  have been approved for disease therapy. In 2009, the U.S. Food and Drug Administration approved Simponi, a human monoclonal antibody to tumor necrosis factor alpha co-developed with Johnson & Johnson's Janssen Biotech, for treatment of arthritis. In 2011, the U.S. FDA approved ipilimumab, a monoclonal antibody to CTLA-4, for treatment of metastatic melanoma. In 2014, the U.S. FDA approved nivolumab, a monoclonal antibody to PD-1, for treatment of advanced melanoma. Its use was expanded to the treatment of squamous non-small-cell lung carcinoma in 2015.<unk>  developed some of the first transgenic mice with humanized immune systems, in order to generate fully human antibodies. Many of the on-market monoclonal antibodies have been derived from this platform.
Medarex
Zestra
Degarelix
Protandim
Clinatec
Almanac
Olestra
Nicogel