Short-term Acute adverse effects are usually the result of high or multiple doses, although single dose toxicity can occur in susceptible individuals. The most serious short-term physical health risks of<unk>  are hyperthermia and dehydration. Cases of life-threatening or fatal hyponatremia (excessively low sodium concentration in the blood) have developed in<unk>  users attempting to prevent dehydration by consuming excessive amounts of water without replenishing electrolytes. The immediate adverse effects of<unk>  use can include: * Dehydration * Hyperthermia * Bruxism (grinding and clenching of the teeth) * Increased wakefulness or insomnia * Increased perspiration and sweating * Increased heart rate and blood pressure * Increased psychomotor activity * Loss of appetite * Nausea and vomiting * Diarrhea * Erectile dysfunction * Visual and auditory hallucinations (rarely) Other adverse effects that may occur or persist for up to a week following cessation of moderate<unk>  use include: ;Physiological * Trismus (lockjaw) * Loss of appetite * Insomnia * Tiredness or lethargy ;Psychological * Anxiety or paranoia * Depression * Irritability * Impulsiveness * Restlessness * Memory impairment * Anhedonia Administration of<unk>  to mice causes DNA damage in their brain, especially when the mice are sleep deprived. Even at the very low doses that are comparable to those self-administered by humans,<unk>  causes oxidative stress and both single and double-strand breaks in the DNA of the hippocampus region of the mouse brain. Long-term , the long-term effects of<unk>  on human brain structure and function have not been fully determined. However, there is consistent evidence of structural and functional deficits in<unk>  users with high lifetime exposure. There is no evidence of structural or functional changes in<unk>  users with only a moderate (2B receptors.<unk>  also induces cardiac epigenetic changes in DNA methylation, particularly hypermethylation changes. During pregnancy delphic analysis regarding 20 popular recreational drugs. Ecstasy was ranked 18th in dependence, physical harm, and social harm.<unk>  is a moderately teratogenic drug (i.e., it is toxic to the fetus). In utero exposure to<unk>  is associated with a neuro- and cardiotoxicity and impaired motor functioning. Motor delays may be temporary during infancy or long-term. The severity of these developmental delays increases with heavier<unk>  use. Reinforcement disorders Approximately 60% of<unk>  users experience withdrawal symptoms when they stop taking<unk> . Some of these symptoms include fatigue, loss of appetite, depression, and trouble concentrating. Tolerance to some of the desired and adverse effects of<unk>  is expected to occur with consistent<unk>  use. A 2007 analysis estimated<unk>  to have a psychological dependence and physical dependence potential roughly three-fourths to four-fifths that of cannabis.<unk>  has been shown to induce ΔFosB in the nucleus accumbens. Because<unk>  releases dopamine in the striatum, the mechanisms by which it induces ΔFosB in the nucleus accumbens are analogous to other dopaminergic psychostimulants. Therefore, chronic use of<unk>  at high doses can result in altered brain structure and drug addiction that occur as a consequence of ΔFosB overexpression in the nucleus accumbens.<unk>  is less addictive than other stimulants such as methamphetamine and cocaine. Compared with amphetamine,<unk>  and its metabolite MDA are less reinforcing. One study found approximately 15% of chronic<unk>  users met the DSM-IV diagnostic criteria for substance dependence. However, there is little evidence for a specific diagnosable<unk>  dependence syndrome because<unk>  is typically used relatively infrequently. There are currently no medications to treat<unk>  addiction. Harm assessment A 2007 UK study ranked<unk>  18th in harmfulness out of 20 recreational drugs. Rankings for each drug were based on the risk for acute physical harm, the propensity for physical and psychological dependency on the drug, and the negative familial and societal impacts of the drug. The authors did not evaluate or rate the negative impact of ecstasy on the cognitive health of ecstasy users (e.g. impaired memory and concentration).
MDMA
Phencyclidine
Theobromine
Benzocaine
Heroin
Cocaine
Cocaine 
Amphetamine