No specific treatment is known that would prevent, slow, or reverse<unk> . Available therapies mainly consist of symptomatic medical management and promoting physical and emotional well-being. Therapeutics offered to<unk>  patients include: * Baclofen – a voluntary muscle relaxant to relax muscles and reduce tone. This can be administered orally or intrathecally. (Studies in<unk>  ) * Tizanidine – to treat nocturnal or intermittent spasms (studies available ) * Diazepam and clonazepam – to decrease intensity of spasms * Oxybutynin chloride – an involuntary muscle relaxant and spasmolytic agent, used to reduce<unk> ity of the bladder in patients with bladder control problems * Tolterodine tartrate – an involuntary muscle relaxant and spasmolytic agent, used to reduce<unk> ity of the bladder in patients with bladder control problems * Cro System – to reduce muscle overactivity (existing studies for<unk> ity ) * Botulinum toxin – to reduce muscle overactivity (existing studies for<unk>  patients) * Antidepressants (such as selective serotonin re-uptake inhibitors, tricyclic antidepressants and monoamine oxidase inhibitors) – for patients experiencing clinical depression * Physical therapy – to restore and maintain the ability to move; to reduce muscle tone; to maintain or improve range of motion and mobility; to increase strength and coordination; to prevent complications, such as frozen joints, contractures, or bedsores.
Hereditary spastic paraplegia
Spinal muscular atrophy
Madras motor neuron disease
Tropical ataxic neuropathy
Spinal and bulbar muscular atrophy
Autosomal recessive cerebellar ataxia type 1
Distal hereditary motor neuronopathies
Congenital distal spinal muscular atrophy