When administered at the initially tested higher doses effective for anti-HIV therapy, the side effects of<unk>  are those shown below. * asthenia, malaise * diarrhea * nausea and vomiting * abdominal pain * dizziness * insomnia * sweating * taste abnormality * metabolic effects, including * hypercholesterolemia * hypertriglyceridemia * elevated transaminases * elevated creatine kinase One of<unk> 's side effects is hyperglycemia, through inhibition of the GLUT4 insulin-regulated transporter, thus keeping glucose from entering fat and muscle cells. This can lead to insulin resistance and cause problems for people with type 2 diabetes. Adverse drug reactions<unk>  exhibits hepatic activity.<unk>  induces CYP1A2 and inhibits the major P450 isoforms 3A4 and 2D6. Concomitant therapy of<unk>  with a variety of medications may result in serious and sometimes fatal drug interactions. Due to it being a strong inhibitor (that causes at least a 5-fold increase in the plasma AUC values, or more than 80% decrease in clearance) of both Cytochrome P450 enzymes CYP2D6 and CYP3A4,<unk>  can severely potentiate and prolong the serious and life-threatening side-effects of the opioid painkiller Oxycodone. Combinations of several drug classes with<unk>  may cause risky side effects: * Opioid analgesics * Antiarrhythmic agents * Anticoagulants * Anticonvulsants * Antidepressants * Antihypertensive drugs * Anxiolytics * Erectile dysfunction medications * Immunosuppressants * HIV treatments * Statins * Steroids
Ritonavir
Amprenavir
Saquinavir
Fosamprenavir
Indinavir
Nelfinavir
Atazanavir
Entecavir