* Since<unk>  is a vasodilator, its antihypertensive effect may be compounded by other medications that affect the blood pressure, including calcium channel blockers, diuretics, and other vasodilating agents. * Because of<unk> 's inhibiting effect on platelet aggregation, there is an increased risk of bleeding, especially among patients who are also taking anticoagulants. * It is not known whether<unk>  is excreted in breast milk. Caution is advised when administering this medication to nursing women. * Caution is advised when administering<unk>  to patients who have impaired kidney or liver function. Common side effects depending on route of administration: * 85% of patients report pain or other reaction at the infusion site. Other side effects may include headache, cough, throat irritation, diarrhea, nausea, rash, jaw pain, vasodilatation, dizziness, edema (swelling), pruritus (itching), and hypotension. Warnings: * Abrupt interruption of the<unk>  infusion can lead to worsening of pulmonary hypertension symptoms, and should be avoided.
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