High levels of bromide chronically impair the membrane of neurons, which progressively impairs neuronal transmission, leading to toxicity, known as<unk> . Bromide has an elimination half-life of 9 to 12 days, which can lead to excessive accumulation. Doses of 0.5 to 1 gram per day of bromide can lead to<unk> . Historically, the therapeutic dose of bromide is about 3 to 5 grams of bromide, thus explaining why chronic toxicity<unk>  was once so common. While significant and sometimes serious disturbances occur to neurologic, psychiatric, dermatological, and gastrointestinal functions, death is rare from<unk> .<unk>  is caused by a neurotoxic effect on the brain which results in somnolence, psychosis, seizures and delirium.<unk>  has also been caused by excessive soda consumption, due to the presence of brominated vegetable oil, leading to headache, fatigue, ataxia, memory loss, and potentially the inability to walk as observed in one case.
Bromism
Variegation 
Caudal duplication
Heteroxeny
Isodisomy
Low copy repeats
Heteroplasmy
Polyploidy