<unk>  <unk>  is a form of idiopathic<unk>  pneumonia featuring elevated numbers of macrophages within the alveoli (air sacs) of the lung. The alveolar macrophages have a characteristic light brown pigmentation and accumulate in the alveolar lumen and septa regions of the lower lobes of the lungs. The typical effects of the macrophage accumulation are inflammation and later fibrosis (thickening and stiffness) of the lung tissue. The term<unk>  is a misnomer. Its name is derived from the former belief that these macrophages were pneumocytes that had desquamated. It is associated with patients with a history of smoking. Since more than 80% of cases occur in smokers, it has been suggested that the term<unk>  should be discarded and the subset occurring in smokers should be replaced with more accurate terms such as smoking-related<unk>  fibrosis (SRIF). Although smoking is the most common cause, studies have shown a relationship between occupational exposures and the development of<unk> , including occupational dust, fire-extinguisher powder, diesel fumes, nylon filaments and beryllium and copper dust. Additionally,<unk>  has been observed in children where it typically presents as a result of surfactant protein gene mutations, indicating that the disease is not always acquired in adulthood. Smoking cessation and avoidance of secondhand smoke exposure are both crucial to preventing disease progression, however, treatment with corticosteroids and immunosuppressive therapy has been reported to be effective pharmacologic intervention. Treatment with methylprednisolone has been reported.
Desquamative interstitial pneumonia
Lymphocytic interstitial pneumonia
Usual interstitial pneumonia
Non-specific interstitial pneumonia
Granulomatous–lymphocytic interstitial lung disease
Diffuse panbronchiolitis
Diffuse alveolar damage
Pulmonary alveolar microlithiasis