Mechanisms of SIOP include: * Direct inhibition of osteoblast function * Direct enhancement of bone resorption * Inhibition of gastrointestinal calcium absorption * Increased urine calcium loss * Inhibition of sex steroids The combination of these changes leads to drug-induced nutrient depletion. Prednisone moderately depletes calcium, vitamin D, chromium and magnesium. This explains why the professional guidelines recommend calcium and vitamin D supplementation.
Steroid-induced osteoporosis
Vitamin D toxicity
Endocrine bone disease
Metabolic bone disease
Corticosteroid-induced lipodystrophy
Oncogenic osteomalacia
Vitamin D deficiency
Secondary hyperparathyroidism