Ran cycle of nuclear transport.<unk>  inhibits this process at the nuclear export receptor (upper right). Like other selective inhibitors of nuclear export (SINEs),<unk>  works by binding to exportin 1 (also known as XPO1 or CRM1). XPO1 is a karyopherin which performs nuclear transport of several proteins, including tumor suppressors, oncogenes, and proteins involved in governing cell growth, from the cell nucleus to the cytoplasm; it is often overexpressed and its function misregulated in several types of cancer. By inhibiting the XPO1 protein, SINEs lead to a buildup of tumor suppressors in the nucleus of malignant cells and reduce levels of oncogene products which drive cell proliferation. This ultimately leads to cell cycle arrest and death of cancer cells by apoptosis. In vitro, this effect appeared to spare normal (non-malignant) cells. Inhibiting XPO1 affects many different cells in the body which may explain the incidence of adverse reactions to<unk> . Thrombocytopenia, for example, is a mechanistic and dose-dependent effect, occurring because<unk>  causes a buildup of the transcription factor STAT3 in the nucleus of hematopoietic stem cells, preventing their differentiation into mature megakaryocytes (platelet-producing cells) and thus slowing production of new platelets.
Selinexor
Mitapivat
Enarodustat
Tezacaftor
Eliglustat
Pleconaril
Pergolide
Tetryzoline