NF-2 may be inherited in an autosomal dominant fashion, as well as through random mutation.<unk>  is caused by inactivating mutations in the<unk>  gene located at 22q12.2 of chromosome 22, type of mutations vary and include protein-truncating alterations (frameshift deletions/insertions and nonsense mutations), splice-site mutations, missense mutations and others. Deletions, too, in the NH2-terminal domain of merlin proteins have been associated with early tumor onset and poor prognosis in people with<unk> . Protein truncating mutations correlate with more severe phenotype. There is a broad clinical spectrum known, but all people with the condition who have been checked have been found to have some mutation of the same gene on chromosome 22. Through statistics, it is suspected that one-half of cases are inherited, and one-half are the result of new, de novo mutations.
Neurofibromatosis type II
Neurofibromatosis type 4
Tuberous sclerosis
Von Hippel–Lindau disease
Fox–Fordyce disease
Progeria
Fabry disease
Irlen syndrome