RVP production requires optimization of several elements, such as expression constructs, cell lines, and processing steps, to reach a yield sufficient for downstream applications and reproducibility across production lots. Although ideal for studying the effects of the immune response on virus entry, RVPs are replication-incompetent, and therefore typically do not allow study of the later stages of the viral life cycle. RVPs formed by pseudotyping contain the native form of the viral Envelope (or Spike) protein, but may not contain other structural elements from the original virus. Results obtained with RVPs are often compared to those obtained with live virus.
Reporter virus particles
Genetically modified virus
Genetically modified bacteria
Microbial cell factory
Virus counter
Virulence factor
Bacterial adhesin
Tax gene product