The most significant adverse effects of<unk>  include diarrhea, nausea and vomiting, neutropenia and fever, infections of blood or lungs (sepsis, pneumonia), shock, dehydration, kidney failure and thrombocytopenia (low levels of blood platelets). Diarrhea<unk> -associated diarrhea is severe and clinically significant, sometimes leading to severe dehydration requiring hospitalization or intensive care unit admission. This side-effect is managed with the aggressive use of antidiarrheals such as loperamide or atropine with the first loose bowel movement. Immunosuppression The immune system is adversely impacted by<unk> . This is reflected in – sometimes dramatically – lowered white blood cell counts in the blood, in particular the neutrophils. The patient may experience neutropenia (a clinically significant decrease of neutrophils in the blood).
Irinotecan
Ifosfamide
Vincristine
Topotecan
Etoposide
Normustine
Trifluridine
Doxorubicin