<unk>  metabolizes into<unk>  and ritalinic acid. Tiny amounts of<unk>  can be formed in vivo when a replace with Category:Alcohol solvents (specifically ethanol <- Link Ethanol as the (drug)) and<unk>  are coingested, via hepatic transesterification.<unk>  formation appears to be more common when large quantities of<unk>  and alcohol are consumed at the same time, such as in non-medical use or overdose scenarios. However, the transesterfication process of<unk>  to<unk> , as tested in mice liver, was dominant in the inactive (−)-enantiomer but showed a prolonged and increased maximal plasma concentration of the active (+)-enantiomer of<unk> . Additionally, only a few percent of the consumed<unk>  is converted to<unk> . This carboxylesterase-dependent transesterification process is also known to occur when cocaine and alcohol are consumed together, forming cocaethylene.
Ethylphenidate
Methylphenidate
Dexmethylphenidate
Atomoxetine
Guanfacine
Risperidone
Chlortalidone
Trimipramine