Gallstones Symptoms can be extremely varied among those suffering from<unk> . The majority of those suffering from the disease are detected at birth while some only present symptoms during times of great physiological stress such as pregnancy, or with acute illnesses (viral disorders). Symptoms are limited to or most severe during childhood. Among the symptoms of<unk>  are: * Mild to severe hemolytic Anemia * Cholecystolithiasis * Tachycardia * Hemochromatosis * Icteric sclera * Splenomegaly * Leg ulcers * Jaundice * Fatigue * Shortness of breath The level of 2,3-bisphosphoglycerate is elevated: 1,3-bisphosphoglycerate, a precursor of phosphoenolpyruvate which is the substrate for<unk>  kinase, is increased and so the Luebering-Rapoport pathway is overactivated. This led to a rightward shift in the oxygen dissociation curve of hemoglobin (i.e. it decreases the hemoglobin affinity for oxygen): In consequence, patients may tolerate anemia surprisingly well.
Pyruvate kinase deficiency
Glucose-6-phosphate dehydrogenase deficiency
Glutaminase deficiency
Malonyl-CoA decarboxylase deficiency
Pyruvate carboxylase deficiency
3-Methylcrotonyl-CoA carboxylase deficiency
2,4 Dienoyl-CoA reductase deficiency
Hexokinase deficiency