Each step in the peptide loading and presentation on MHC I (or MHC II) is a potential target for viral<unk> s. These can range from targeting MHC I for lysosomal or cytoplasmic degradation, blocking TCR recognition of MHC I, inhibition of peptide transport into the ER or retention of MHC I in the ER or pre-Golgi. For MHC II, the possible evasion routes include MHC II-peptide assembly disruption, evading TCR recognition, MHC II degradation, and, conversely, CD4 co-receptor downregulation. Prevention of NK cell activation may also be triggered by inhibition of presentation of induced-self molecules (ligands of NKG2D) or self molecules (MHC I) presentation (while also preventing the interaction with cytotoxic T lymphocytes).
Immunoevasin
Tetanospasmin
Endrin
Hyperforin
Pentostatin
Kallikrein
Haptocorrin
Defensin