Pharmacodynamics<unk>  acts primarily by blocking post-synaptic D2 receptors in the basal ganglia, cortical and limbic system. It also blocks alpha-1 adrenergic receptors, muscarinic-1 receptors, and histamine-1 receptors. +<unk>  Site Ki (nM) Action Ref 5-HT1A 145-2829 5-HT1B 334 5-HT1D 334 5-HT1E 540 5-HT2A 3.8-98 5-HT2B 5-HT2C 174–2,570 5-HT3 4,265- > 10,000 5-HT5A 145 5-HT6 7.9 - 38 5-HT7 8 D1 14.45 D2 0.89 D2L D3 1.412 D4 89.12 D5 95–2,590 α1A 6.4-9 α1B 13 α2A 304-314 α2B 181.6-320 α2C 28.8-122 β1 > 10,000 β2 > 10,000 H1 7.3-70 H2 560 H3 1,000 H4 > 10,000 M1 1,095-3,235.93 M2 2,187.76-7,163 M3 1441–1445.4 M4 5,321 M5 357 () Values are Ki (nM). The smaller the value, the more strongly the drug binds to the site. All data are for human cloned proteins, except 5-HT3 (rat), D4 (human/rat), H3 (guinea pig), and NMDA/PCP (rat). Pharmacokinetics
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