<unk>  is a synthetic analogue of 2′-deoxy-guanosine. It is first phosphorylated to<unk>  monophosphate by a viral kinase encoded by the cytomegalovirus (CMV) gene UL97 during infection. Subsequently, cellular kinases catalyze the formation of<unk>  diphosphate and<unk>  triphosphate, which is present in 10-fold greater concentrations in CMV or herpes simplex virus (HSV)-infected cells than uninfected cells.<unk>  triphosphate is a competitive inhibitor of deoxyguanosine triphosphate (dGTP) incorporation into DNA and preferentially inhibits viral DNA polymerases more than cellular DNA polymerases. In addition,<unk>  triphosphate serves as a poor substrate for chain elongation, thereby disrupting viral DNA synthesis by a second route.
Ganciclovir
Valganciclovir
Aciclovir
Penciclovir
Letermovir
Brincidofovir
Cidofovir
Lamivudine