The<unk> s are highly metabolised by the cytochrome P450 (CYP) hepatic enzymes. Drugs that inhibit cytochrome P450 (for example cimetidine, methylphenidate, fluoxetine, antipsychotics, and calcium channel blockers) may produce decreases in the<unk> s' metabolism, leading to increases in their blood concentrations and accompanying toxicity. The major factor that distinguishes SSRI's amongst one another is the inhibition of select CYP enzymes . Drugs that prolong the QT interval including antiarrhythmics such as quinidine, the antihistamines astemizole and terfenadine, and some antipsychotics may increase the chance of ventricular dysrhythmias.<unk> s may enhance the response to alcohol and the effects of barbiturates and other CNS depressants. Side effects may also be enhanced by other drugs that have antimuscarinic properties.
Tricyclic antidepressant
Tetracyclic antidepressant
Atypical antidepressant
Heterocyclic antidepressant
Second-generation antidepressant
Antipsychotic
Atypical antipsychotic
Antipsychotic ester