<unk>  can be treated by using enzyme inhibitor therapy. Examples of inhibitors that have been used to block<unk> s and disrupt<unk>  include imatinib, nilotinib, dasatinib, and ponatinib, among others. While initial treatment may have striking, positive results for controlling the cancer, chronic treatment often results in acquired resistance to the drugs and relapse.<unk>  inhibition typically results progression-free survival of a few months, meaning most cancer treatment ultimately relies on frontline chemotherapy. The notable exception is the success of inhibitor therapy in treating CML. Inhibitor therapy has been so successful in this disease, the average progression-free survival time is still unknown, as it has not been reached in more than ten years of followup. More recent understanding of inhibitor resistance is that inhibition of a single gene can cause the signaling pathways to rewire. This rewiring can rescue the downstream processes that signal to and maintain the cancer.
Oncogene addiction
Chromosomal translocation
Neuroplasticity
Tumor progression
Antineoplastic resistance
Tbx18 transduction
Suppressor mutation
Catastrophic injury