<unk>  produces beta-lactamases, and it is also able to modify its penicillin-binding proteins, so it has gained resistance to the penicillin family of antibiotics. In severe cases, cefotaxime and ceftriaxone delivered directly into the bloodstream are the elected antibiotics, and, for the less severe cases, an association of ampicillin and sulbactam, cephalosporins of the second and third generation, or fluoroquinolones are preferred. (Fluoroquinolone-resistant<unk>  have been observed.) Macrolides and fluoroquinolones have activity against non-typeable H.<unk>  and could be used in patients with a<unk> story of allergy to beta-lactam antibiotics. However, macrolide resistance has also been observed.
Haemophilus influenzae
Bordetella pertussis
Streptococcus bovis
Neisseria meningitidis
Bacillus anthracis
Rhodococcus equi
Bordetella bronchiseptica
Streptococcus pyogenes