<unk> in the context of chemotherapy is an acronym for one of the chemotherapy regimens used for treatment of relapsed or refractory aggressive non-Hodgkin's lymphoma and Hodgkin's lymphoma. Today this regimen is often combined with monoclonal antibody rituximab. In this case the regimen is called R-MINE or<unk> R. The R-MINE regimen consists of: # Rituximab - anti-CD20 monoclonal antibody that can kill both normal CD20-expressing B cells and malignant ones; # Mesna to prevent the development of hemorrhagic cystitis which may otherwise result from ifosfamide administration; # Ifosfamide - an alkylating antineoplastic agent from oxazafosforine group; # Mitoxantrone - a synthetic anthracycline analogue (anthraquinone) that is able to intercalate DNA and thus prevent cell division (mitosis); # Etoposide - a topoisomerase inhibitor.
MINE 
NLM
GNE 
HOHMS
DIMP 
CAREN
DKMS
IOMAI