The most common effects when taking<unk>  are nausea, dizziness, dry mouth, headache, diarrhea, and insomnia. Discontinuation due to adverse effects is dose related. According to McMahon in recent study in Asia, the rate of discontinuation is 0.3%, 1.7%, and 5.3% of 1067 studied subjects with placebo,<unk>  30 mg, and<unk>  60 mg, respectively. Unlike other SSRIs used to treat depression, which have been associated with high incidences of sexual dysfunction,<unk>  is associated with low rates of sexual dysfunction. Taken as needed,<unk>  has very mild adverse effects of decreased libido (<1%) and erectile dysfunction (<4%). Overdose No case of drug overdose has been reported during clinical trials. Interactions With phosphodiesterase inhibitors (PDE5 inhibitors) Many men who have PE also suffer from erectile dysfunction (ED). Treatment for these patients should consider the drug–drug interaction between<unk>  and PDE5 inhibitors such as tadalafil (Cialis) or sildenafil (Viagra). In Dresser study (2006), plasma concentration of 24 subjects was obtained. Half of the sample pool were treated with<unk>  60 mg + tadalafil 20 mg; the other half were treated with<unk>  60 mg + sildenafil 100 mg. These plasma samples were then analyzed using liquid chromatography-tandem mass spectrometry. The results showed that<unk>  does not alter the pharmacokinetic of tadalafil or sildenafil. With ethanol Ethanol does not affect the pharmacokinetics of<unk>  when taking concurrently.
Dapoxetine
Atomoxetine
Duloxetine
Edivoxetine
Vortioxetine
Fluoxetine
Nabilone
Guanfacine