The pathway of metabolism, by most tested species, is by hydroxylation of the alicyclic ring to yield monohydroxylated metabolites with trace amounts of dihydroxylated product. This pathway occurs in rats, hamsters, rabbits, squirrel monkeys, cynomolgus monkeys, baboons and humans, where the metabolites are found in urine and faeces. For dogs a different elimination occurs, which is essentially as the unchanged drug. The reason for this difference in species, results from the dog having a higher dependence on biliary excretion of the unchanged drug for clearance. The value of the plasma clearance for dogs (0.2 ml min-1 kg-1), is 20 fold lower than the value for rats (4.1 ml min-1 kg-1), a species which is capable of metabolism. This difference leads to the different clearance route. Which becomes saturated after administration of a toxic dose of the drug. If the metabolism of<unk>  in a rat is inhibited with SKF-525A, the plasma clearance of<unk>  is lowered (0.6 ml min-1 kg-1), which increases the amount of unchanged drug cleared by biliary excretion. After giving nursing rat mothers<unk> , the drug and its metabolites gets also excrete in the milk of these rats. At a maternal dose level of 20 mg/kg, an amount 1-2% was present in the milk. From which 63% was<unk>  and 37% the hydroxylated metabolites.
Proxicromil
Plerixafor
Enarodustat
Coralmyn
Truenat
Ecallantide
Carctol
Tiratricol