Chemical structure of the<unk>  trazodone.<unk> s (SARIs) are a class of drugs used mainly as antidepressants, but also as anxiolytics and hypnotics. They act by antagonizing serotonin receptors such as 5-HT2A and inhibiting the reuptake of serotonin, norepinephrine, and/or dopamine. Additionally, most also antagonize α1-adrenergic receptors. The majority of the currently marketed SARIs belong to the phenylpiperazine class of compounds.
Serotonin antagonist and reuptake inhibitor
Opioid antagonist
Serotonin–dopamine reuptake inhibitor
Serotonin receptor agonist
Serotonin–norepinephrine–dopamine reuptake inhibitor
Glycine reuptake inhibitor
Dopamine reuptake inhibitor
Serotonin–norepinephrine reuptake inhibitor