In terms of its structure,<unk>  differs from cisplatin in that it has a bidentate dicarboxylate (the ligand is CycloButane DiCarboxylic Acid,<unk>  in place of the two chloride ligands, which are the leaving groups in cisplatin. For this reason,<unk> " is sometimes used in the medical literature as an abbreviation referring to<unk> .<unk>  exhibits lower reactivity and slower DNA binding kinetics, although it forms the same reaction products in vitro at equivalent doses with cisplatin. Unlike cisplatin,<unk>  may be susceptible to alternative mechanisms. Some results show that cisplatin and<unk>  cause different morphological changes in MCF-7 cell lines while exerting their cytotoxic behaviour. The diminished reactivity limits protein-carboplatin complexes, which are excreted. The lower excretion rate of<unk>  means that more is retained in the body, and hence its effects are longer lasting (a retention half-life of 30 hours for<unk> , compared to 1.5-3.6 hours in the case of cisplatin).
Carboplatin
Ifosfamide
Lipoplatin
Vincristine
Etoposide
Doxorubicin
Lomustine
Epirubicin