Wagner-Jauregg’s 1917 treatment method, also known as malariotherapy, involved the introduction of Plasmodium vivax malaria via injection into patients with advanced stages of syphilis. Advanced syphilitic infection can invade the brain causing neurosyphilis, affecting neural performance and function, which can in turn lead to general paresis of the insane (GPI), a severely debilitating mental disorder. Doing so induced high-grade (103 °F, 39.4 °C or above) fever that was easily sustainable to eradicate invading spirochaetal bacterium Treponema pallidum, the pathogen responsible for syphilitic infection. Successive rounds of treatment were required to fully eradicate the infectious bacteria, while simultaneously using quinine to treat the malaria infection. Management of the fevers was risky as malaria fevers can sometimes cause death, but syphilis was a proliferate and terminal disease at the time with no other viable treatment. This procedure was used to treat syphilis until penicillin was found to be a safer, more effective measure in the 1940s. The general paresis of the insane caused by neurosyphilis was effectively overcome by the method.<unk>  was also employed in psychiatry. Of note here is the use of sulfozinum and pyrogenal that was relatively widespread in Soviet psychiatry. Against schizophrenia "Saprovitan" and "Pyrifer" were tried.
Pyrotherapy
Hypophysectomy
Thyroplasty
Growth hormone therapy
Parathyroidectomy
Crown lengthening
Thyroidectomy
Labial frenectomy