Although in itself<unk>  is neither degenerative nor fatal, the chronic pain of<unk>  is pervasive and persistent. Most people with<unk>  report that their symptoms do not improve over time. However, most patients learn to adapt to the symptoms over time. The German guidelines for patients explain that: # The symptoms of<unk>  are persistent in nearly all patients. # Total relief of symptoms is seldom achieved. # The symptoms do not lead to disablement and do not shorten life expectancy. An 11-year follow-up study on 1555 patients found that most remained with high levels of self-reported symptoms and distress. However, there was a great deal of patient heterogeneity accounting for almost half of the variance. At the final observation, 10% of the patients showed substantial improvement minimal symptoms. An additional 15% had moderate improvement. This state, though, may be transient, given the fluctuations in symptom severity. A study of 97 adolescents diagnosed with<unk>  followed them for eight years. After eight years, the majority of youth still suffer from pain and disability in physical, social, and psychological areas. At the last follow-up, all participants reported experiencing one or more<unk>  symptoms such pain, fatigue, and/or sleep problems, with 58% matching the complete ACR 2010 criteria for<unk> . Based on the WPI and SS score cut-points, the remaining 42% exhibited subclinical symptoms. Pain and emotional symptom trajectories, on the other hand, displayed a variety of longitudinal patterns. The study concluded that while most patient's<unk>  symptoms endure, the severity of their pain tends to reduce over time. Baseline depressive symptoms in adolescents appear to predict worse pain at follow-up periods.
Fibromyalgia
Osteoarthritis
Polymyalgia rheumatica
Rheumatoid arthritis
Complex regional pain syndrome
Myofascial pain syndrome
Thyroid disease
Calpainopathy