<unk>  <unk>  is a rare bone marrow blood cancer. It is classified by the World Health Organization (WHO) as a type of myeloproliferative neoplasm, a group of cancers in which there is growth of abnormal cells in the bone marrow. This is most often associated with a somatic mutation in the JAK2, CALR, or MPL gene markers. In<unk> , the healthy marrow is replaced by scar tissue (fibrosis), resulting in a lack of production of normal blood cells. Symptoms include anemia, increased infection and an enlarged spleen (splenomegaly). In 2016, prefibrotic<unk>  was formally classified as a distinct condition that progresses to overt<unk>  in many patients, the primary diagnostic difference being the grade of fibrosis.
Primary myelofibrosis
Prefibrotic primary myelofibrosis
Acute panmyelosis with myelofibrosis
Chronic neutrophilic leukemia
Acute myeloid leukemia
Leukemoid reaction
Myelodysplastic syndrome
Chronic lymphocytic leukemia