Typically,<unk>  patients have both their nipple and areola missing, and the nipple may be absent on one or both sides of the breasts. Abnormalities are not often associated with the breasts. However, symptoms such as hypertelorism, saddle nose, cleft palate, urologic disorders and dysfunction of muscle, upper and lower limb have been observed. Sometimes several members of a family can be diagnosed as<unk>  simultaneously, all of them are carriers of mutations in TBX3 gene. This mutation could cause various abnormalities, not only<unk> , but also deformation of limb and teeth. Cases of unilateral<unk>  are uncommon, and they are often associated with hypoplasia of pectoral major muscle and/or the thorax. Bilateral<unk>  is more common because it is often associated with other different syndromes. Therefore, the symptoms of bilateral<unk>  are easier to be diagnosed. Various associated syndromes are listed below.
Amastia
Hamartia 
Macrodontia 
Macrotia
Acrania
Spotted lunulae
Cystic eyeball
Auricular hypertrichosis