The conjugated hyperbilirubinemia is a result of defective endogenous and exogenous transfer of anionic conjugates from hepatocytes into bile. Impaired biliary excretion of bilirubin glucuronides is due to a mutation in the canalicular multiple drug-resistance protein 2 (MRP2). A darkly pigmented liver is due to polymerized epinephrine metabolites, not bilirubin.<unk>  has an autosomal recessive pattern of inheritance.<unk>  is due to a defect in the multiple drug resistance protein 2 gene (ABCC2), located on chromosome 10. It is an autosomal recessive disease and is likely due to a loss of function mutation, since the mutation affects the cytoplasmic/binding domain.
Dubin–Johnson syndrome
Gilbert's syndrome  Gilbert's syndrome  1
Rubinstein–Taybi syndrome
Gaucher's disease
Vanishing bile duct syndrome
Crigler–Najjar syndrome
Gilbert's syndrome
Hereditary hyperbilirubinemia