Pain, visual loss, relapse, and steroid response are typical of CRION. Ocular pain is typical, although there are some cases with no reported pain. Bilateral severe visual loss (simultaneous or sequential) usually occurs, but there are reports of unilateral visual loss. Patients can have an associated relative afferent pupillary defect. CRION is associated with at least one relapse, and up to 18 relapses have been reported in an individual. Interval between episodes can range from days to over a decade. Symptoms will improve with corticosteroids, and recurrence characteristically occurs after reducing or stopping steroids.
Chronic relapsing inflammatory optic neuropathy
Toxic and nutritional optic neuropathy
Autoimmune optic neuropathy
Arteritic anterior ischemic optic neuropathy
Late congenital syphilitic oculopathy
Punctate inner choroiditis
Posterior ischemic optic neuropathy
Persistent hyperplastic primary vitreous