Symptoms of holoprosencephaly range from mild (no facial/organ defects, anosmia, or only a single central incisor) to moderate to severe (cyclopia). The symptoms are dependent upon the classification type. There are four classifications of holoprosencephaly as well as a mild "microform". Gross pathology specimen from a case of alobar holoprosencephaly * Alobar * Most severe form includes formation of synophthalmia (a single central eye),proboscis, and severe impairment. * Semilobar * Can present with severely decreased distance between eyes, a flat nasal bridge, eye defects, cleft lip and palate, and severe impairment. * Lobar * Can present with decreased distance between eyes, a flat nasal bridge, closely spaced nostrils, mental and locomotion delays may be present. * Syntelencephaly or middle interhemispheric variant of holoprosencephaly (MIHV) * Mild phenotypic presentation which can present with flat nasal bridge, metopic prominence, shallow philtrum, and possible mental and locomotion delays. * "Microform" * Mild phenotypic presentation with reduced distance between eyes, sharp nasal bridge, single maxillary central incisor.
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