The mechanism seems to vary with different organisms and is not well understood. However,<unk>  is suspected to work through various methods of interference of critical functions in DNA, RNA, phospholipid and protein synthesis.<unk>  binds to adenine-thymine-rich regions of the Trypanosoma parasite DNA, forming a cross-link between two adenines four to five base pairs apart. The drug also inhibits topoisomerase enzymes in the mitochondria of Pneumocystis jirovecii. Similarly,<unk>  inhibits type II topoisomerase in the mitochondria of the Trypanosoma parasite, resulting in a broken and unreadable mitochondrial genome. Resistance Strains of the Trypanosoma brucei parasite that are resistant to<unk>  have been discovered.<unk>  is brought into the mitochondria through carrier proteins, and the absence of these carriers prevents the drug from reaching its site of action.
Pentamidine
Isocarboxazid
Trenbolone hexahydrobenzylcarbonate
Delamanid
Dimetacrine
Astemizole
Quinine
Artesunate