<unk> , also known as mucopolysaccharidosis Type IH (MPS-IH),<unk> 's disease, and formerly gargoylism, is a genetic disorder that results in the buildup of large sugar molecules called glycosaminoglycans (GAGs) in lysosomes. The inability to break down these molecules results in a wide variety of symptoms caused by damage to several different organ systems, including but not limited to the nervous system, skeletal system, eyes, and heart. The underlying mechanism is a deficiency of alpha-L iduronidase, an enzyme responsible breaking down GAGs. Without this enzyme, a buildup of dermatan sulfate and heparan sulfate occurs in the body. Symptoms appear during childhood, and early death usually occurs. Other, less severe forms of MPS Type I include<unk> -Scheie Syndrome (MPS-IHS) and Scheie Syndrome (MPS-IS).<unk>  is classified as a lysosomal storage disease. It is clinically related to Hunter syndrome (MPS II); however, Hunter syndrome is X-linked, while<unk>  is autosomal recessive.
Hurler syndrome
Hunter syndrome
Kindler syndrome
Mucopolysaccharidosis
Birk-Barel syndrome
Hurler–Scheie syndrome
Pelger–Huët anomaly
Scheie syndrome