<unk>  acts on benzodiazepine binding site situated on GABAA neurons as a positive allosteric modulator.<unk>  is rapidly absorbed after oral administration, with serum levels peaking between .45 and 1.3 hours. The elimination half-life of<unk>  is approximately 6 hours and it is extensively metabolized by oxidation and demethylation. Approximately 52% to 59% of a dose is weakly bound to plasma protein. Cytochrome P450 (CYP) isozymes CYP3A4 and CYP2E1 are involved in the biotransformation of<unk> ; thus, drugs that induce or inhibit these CYP isozymes may affect the metabolism of<unk> . Less than 10% of the orally administered dose is excreted in the urine as racemic zopiclone. In terms of benzodiazepine receptor binding and relevant potency, 3 mg of<unk>  is equivalent to 10 mg of diazepam.
Eszopiclone
Zopiclone
Chloropicrin
Eliglustat
Hydrastine
Mometasone
Flumetasone
Clobetasone