Disorders that store this intracellular material are part of the lysosomal storage diseases family of disorders. Sphingolipidoses Many<unk> s can be classified into the subgroup of sphingolipidoses, as they relate to sphingolipid metabolism. Members of this group include Niemann-Pick disease, Fabry disease, Krabbe disease, Gaucher disease, Tay–Sachs disease, metachromatic leukodystrophy, multiple sulfatase deficiency, and Farber disease. They are generally inherited in an autosomal recessive fashion, but Fabry disease is X-linked. Taken together, sphingolipidoses have an incidence of approximately 1 in 10,000. Enzyme replacement therapy is available mainly to treat Fabry disease and Gaucher disease and people with these types of sphingolipidoses may live well into adulthood. Generally, the other types are fatal by age 1 to 5 years for infantile forms, but progression may be mild for juvenile-onset or adult-onset forms. Alternatively, some of the sphingolipidoses may be classified into either GM1 gangliosidoses or GM2 gangliosidoses. Tay–Sachs disease belongs to the latter. Other Other<unk> s that generally are not classified as sphingolipidoses include fucosidosis, Schindler disease, and Wolman disease.
Lipid storage disorder
Glycogen storage disease
Lysosomal storage disease
Neutral lipid storage disease
Protein toxicity
Metabolic disorder
Mitochondrial toxicity
Vitamin deficiency