Mutations in four different genes can lead to<unk> . This disorder is inherited in an autosomal recessive pattern. People with two working copies of the gene are unaffected. People with one working copy are genetic carriers of<unk> . They have no symptoms but may pass down the defective gene to their children. People with two defective copies will suffer from<unk> . + Genetics of MPS-III<unk>  type Gene Enzyme Chromosomal region Number of known mutations causing this type Type A SGSH heparan N-sulfatase 17q25.3 137 Type B NAGLU Alpha-N-acetylglucosaminidase 17q21.2 152 Type C HGSNAT acetyl-CoA:alpha-glucosaminide N-acetyltransferase 8p11.21 64 Type D GNS N-acetylglucosamine-6-sulfatase 12q14.3 23
Sanfilippo syndrome
Autism spectrum
DeSanto-Shinawi syndrome
Filippi Syndrome
Treacher Collins syndrome
Pelger–Huët anomaly
Van der Woude syndrome
Van Gogh syndrome