For most individuals with<unk> , symptoms begin to appear within the first 10 to 20 years of age.<unk>  is a neurodegenerative disorder, so the severity of symptoms tend to progress with time. Symptoms of<unk>  can be divided into two main categories: Motor symptoms (symptoms that affect movement) and non-motor symptoms (symptoms that do not affect movement). Motor symptoms include: * Juvenile-onset atypical Parkinsonism (PARK9) * Bradykinesia (slowed movements) * Tremors in the chin, tongue, and in some cases the arms * Rigidity * Postural instability * Supranuclear gaze palsy (inability to move eye in a vertical direction) * Paraplegia (total or partial paralysis of the legs) * Ataxia (loss of coordination of movements) * Dystonia (involuntary muscle contractions leading to abnormal postures) * Dyskinesia (involuntary movements) and hyperreflexia (increased reflexes) * Facial-faucial-finger mini-myoclonus (involuntary muscle contractions of the fingers, face, and passage at the back of the mouth leading to the pharynx) Non-Motor Symptoms Include: * Cognitive mental disability and learning difficulty * Dementia * Visual and auditory hallucinations * Severe anxiety and panic attacks
Kufor–Rakeb syndrome
Kufs disease
Zunich–Kaye syndrome
Irlen syndrome
Simpson–Golabi–Behmel syndrome
Naxos syndrome
Cornelia de Lange syndrome
Letterer–Siwe disease