<unk> -1Alpha The mechanism of<unk>  affects the normal function of IL1RN gene. The protein produced by IL1RN gene prevents the normal activities of<unk> <unk> (alpha) and<unk> <unk> (beta). Therefore, the pathophysiologic immune and inflammatory responses are nullified.<unk> <unk><unk><unk>  (IL1RN) has a total of five alleles, of those the (IL1RN*1) and (IL1RN*2) are the most common as the other alleles are seen less than 5 percent. IL-1RN binds to the same cell<unk> s as the inflammatory protein IL-1, and blocks its inflammatory actions. Without IL-1Ra, the body cannot control systemic inflammation that can be caused by IL-1.
Deficiency of the interleukin-1–receptor antagonist
Leukocyte adhesion molecule deficiency
Terminal complement pathway deficiency
Neutrophil-specific granule deficiency
Acquired C1 esterase inhibitor deficiency
Mendelian susceptibility to mycobacterial disease
CD25 deficiency
Immunodeficiency with hyperimmunoglobulin M