Pharmacodynamics +<unk>  Site Ki (nM) Species Ref 1,3604,30010,000 () HumanRatRat 5,1009901,700 () HumanRatRat 3,9402,8005,200 () HumanRatRat 5-HT1A 7,000 Human 5-HT2A 380 Human 5-HT2C α1 570 Human α2 4,800 Human D2 H1 1.1 Human ' 35 Human Values are Ki (nM), unless otherwise noted. The smaller the value, the more strongly the drug binds to the site. In vitro,<unk>  is a strong antihistamine and anticholinergic, moderate 5-HT2 and α1-adrenergic receptor antagonist, and very weak or negligible monoamine reuptake inhibitor. These actions appear to confer a profile similar to that of iprindole and trimipramine with serotonin-blocking effects as the apparent predominant mediator of mood-lifting efficacy. However, in small clinical trials, using similar doses,<unk>  was found to be similarly effective to amitriptyline and imipramine as an antidepressant, despite the fact that both of these TCAs are far stronger as both 5-HT2 antagonists and serotonin–norepinephrine reuptake inhibitors. As a result, it may be that<unk>  has a different mechanism of action, or perhaps functions as a prodrug in the body to a metabolite with different pharmacodynamics. Pharmacokinetics Therapeutic concentrations of<unk>  are in the range of 60–280 ng/mL (204–954 nmol/L). Its plasma protein binding is greater than 90%.
Butriptyline
Sertindole
Protriptyline
Pargyline
Rivastigmine
Iobitridol
Desomorphine
Influenzanet