<unk>  is contraindicated in people with epilepsy or who are otherwise prone to seizures. It raises intracranial pressure so should not be used in people with head injuries, brain tumors, or other conditions which increase intracranial pressure. It increases the risk of respiratory depression so should not be used in people with asthma. As with other mu-opioid agonists,<unk>  may cause spasms of the sphincter of Oddi, and is therefore discouraged for use in patients with biliary tract disease such as both acute and chronic pancreatitis. People who are rapid or ultra rapid metabolizers for the CYP2C9, CYP2C19, and CYP2D6 enzymes may not respond adequately to<unk>  therapy. Due to reduced clearance,<unk>  should be administered with caution to people with moderate liver disease and not at all in people with severe liver disease.
Tapentadol
Tramadol
Desmetramadol
Acetylmethadol
Hydrocodone
Etodolac
Ketorolac
Noroxycodone