In some cases, signs and symptoms of<unk>  first appear later in childhood or during the teenage years and progress more slowly. Children with<unk>  experience progressive difficulties with movement. Generally they have muscles that are at first weak and "floppy" (hypotonic), and then gradually become very stiff (spastic). Eventually, affected children lose the ability to move independently. Lack of muscle strength causes difficulty with feeding and breathing problems that can lead to frequent infections, such as pneumonia. Seizures occur in some affected children. Rapid, involuntary eye movements (nystagmus), eyes that do not look in the same direction (strabismus), and vision loss due to deterioration (atrophy) of the optic nerve are characteristic of<unk> . Hearing loss may also develop. Children with this disorder experience progressive deterioration of cognitive functions (dementia), and eventually lose awareness of their surroundings.<unk>  is characterized by the development of swellings called spheroid bodies in the axons, the fibers that extend from nerve cells (neurons) and transmit impulses to muscles and other neurons. A part of the brain called the cerebellum, which helps to control movements, may also be damaged. In some individuals with<unk> , abnormal amounts of iron accumulate in a specific region of the brain called the basal ganglia.
Infantile neuroaxonal dystrophy
Ullrich congenital muscular dystrophy
Congenital muscular dystrophy
Spinal muscular atrophy
Myotonic dystrophy
Madras motor neuron disease
Distal spinal muscular atrophy type 1
Distal spinal muscular atrophy type 2