The ubiquitous distribution of<unk>  peptides and receptors implicates involvement in a wide variety of physiological and pathological processes among different organ systems. Among numerous diseases potentially occurring from<unk>  dysregulation are: * several types of cancer * cerebral vasospasm following subarachnoid hemorrhage * arterial hypertension, pulmonary hypertension, and other cardiovascular disorders * pain mediation *cardiac hypertrophy and heart failure *Dengue haemorrhagic fever *Type II diabetes *some cases of Hirschsprung disease In insulin resistance the high levels of blood insulin results in increased production and activity of<unk> -1, which promotes vasoconstriction and elevates blood pressure.<unk> -1 impairs glucose uptake in the skeletal muscles of insulin resistant subjects, thereby worsening insulin resistance. In preliminary research, injection of<unk> -1 into a lateral cerebral ventricle was shown to potently stimulate glucose metabolism in specified interconnected circuits of the brain, and to induce convulsions, indicating its potential for diverse neural effects in conditions such as epilepsy. Receptors for<unk> -1 exist in brain neurons, indicating a potential role in neural functions.
Endothelin
Endrin
Angiotensin II 
Prostacyclin
Vasopressin 
Vasopressin
Adrenomedullin
Bryostatin