The effects of abnormal<unk>  levels or function impacts the clinical world. The impact<unk>  has on the brain can lead to future work in inhibition through targeted therapy, specifically with diseases associated with the brain as this enzyme may take part in the developmental pathways of neuronal disorders. The introduction of<unk> s may also have medical benefits. In the context of graft versus host disease,<unk>  can be introduced as an inducible switch. In the presence of a small molecule, it will dimerize and trigger apoptosis, eliminating lymphocytes. iCasp9 iCasp9 (inducible<unk>  is a type of control system for chimeric antigen receptor T cells (CAR T cells). CAR T cells are genetically modified T cells that exhibit cytotoxicity to tumor cells. Evidence shows that CAR T cells are effective in treating B-cell malignancies. However, as CAR T cells introduce toxicity, user control of the cells and their targets is critical. One of the various ways to exert control over CAR T cell is through drug-controlled synthetic systems. iCasp9 was created by modifying<unk>  and fusing it with the FK506 binding protein. iCasp9 can be added to the CAR T cells as an inducible suicide gene. If therapy with CAR T cells results in severe side effects, iCasp9 can be used to halt treatment. Administering a small-molecule drug such as rapamycin causes the drug to bind to the FK506 domain. This, in turn, induces expression of<unk> , which triggers cell death of the CAR T cells.
Caspase-9
STAT protein
NLRP3
Bcl-xL
Zinc transporter 8
Fc receptor
IKK2
Thromboxane receptor