In allergy, mast cells release inflammatory substances such as histamine, neutral proteases, arachidonic acid derivatives, platelet activating factor and a variety of cytokines and chemokines. These mediators can precipitate coronary artery spasm and accelerate the rupture of atheromatous plaques of the coronary arteries. This interferes with the blood flow to the heart muscle and causes symptoms otherwise indistinguishable from unstable angina. It is possible that even in people without direct evidence of allergy, the allergic response may be playing a role in acute coronary syndrome: markers of mast cell activation are found in people with ACS.
Kounis syndrome
Kufor–Rakeb syndrome
Zunich–Kaye syndrome
STAR syndrome
Simpson–Golabi–Behmel syndrome
RAPADILINO syndrome
Qazi–Markouizos syndrome
Malouf syndrome