An inheritable gene variation may cause increased susceptibility. People with a variation in a gene that encodes the cartilage intermediate-layer protein (CILP) were 1.6 times more likely to have the disease than persons without the variation. CILP is a normal component of disc tissue. The gene variant was hypothesized to disrupt normal building and maintenance of cartilage. However, this association was not replicated in a follow-up study of Finnish and Chinese individuals.
Lumbar disc disease
Degenerative disc disease
Spinal disease
Spinal disc herniation
Spinal stenosis
Lumbar spinal stenosis
Spinal tumor
Discitis