<unk>  <unk>  are<unk>  that are archetypically associated with the<unk>  system of the brain's cerebral cortex. When such<unk>  are caused by medications or other drugs, they are also known as<unk>  side effects <unk> E). The<unk>  can be acute (short-term) or chronic (long-term). They include movement dysfunction such as dystonia (continuous spasms and muscle contractions), akathisia (may manifest as motor restlessness), parkinsonism characteristic<unk>  such as rigidity, bradykinesia (slowness of movement), tremor, and tardive dyskinesia (irregular, jerky movements).<unk>  are a reason why subjects drop out of clinical trials of antipsychotics; of the 213 (14.6%) subjects that dropped out of one of the largest clinical trials of antipsychotics (the CATIE trial (Clinical Antipsychotic Trials for Intervention Effectiveness), which included 1460 randomized subjects), 58 (27.2%) of those discontinuations were due to<unk> .
Extrapyramidal symptoms
Sickness behavior
Pain asymbolia
Pseudobulbar affect
Neurosis
Pyramidal signs
Dyssomnia
Amnesia