<unk>  is a photochromic antifolate drug developed at the Institute for Bioengineering of Catalonia (IBEC, The Barcelona Institute of Science and Technology). In particular, it is a photopharmacological agent that behaves as light-regulated inhibitor of the dihydrofolate reductase (DHFR) enzyme.<unk>  is a photoisomerizable structural analogue of the chemotherapy agent methotrexate. It is also an example of "azologization". Pharmacological effects of<unk>  can be switched on and off by UVA and visible light, respectively.<unk>  is almost inactive in its trans configuration while it behaves as a potent antifolate in its cis configuration. It can also spontaneously self-deactivate in the dark. cis-Phototrexate
Phototrexate
Methotrexate
Cyclophosphamide
Lenalidomide
Ifosfamide
Rituximab
Pomalidomide
Vincristine