A variety of<unk>  reuptake transporters are pharmacotherapeutic targets for modulating the synaptic<unk>  concentration, and therefore neurotransmission. * Antidepressants such as SSRIs, SNRIs and TCAs suppress the activity of serotonin and/or norepinephrine transporters, preventing the reuptake of targeted<unk> s from the synaptic cleft. * Psychostimulants like cocaine, amphetamines, and methylphenidate act by inhibiting and/or reversing the dopamine and/or norepinephrine transporters. Some dissociatives like phencyclidine and ketamine are also dopamine transporter inhibitors. * Tiagabine, a drug used as an anticonvulsant, acts by inhibiting the GABA transporter 1.<unk> s inhibitors Vesicular transporters could provide an alternative therapeutic target for the modulation of chemical neurotransmission, as the activity of these transporters could affect the quantity of<unk>  released. * Vesamicol, for example, is an inhibitor of the vesicular acetylcholine transporter. It prevents the loading of ACh into the presynaptic vesicles, causing a fall in the amount that is released in response to a neuronal action potential. It is not used clinically, but provides a useful tool for research into the behaviour of<unk>  vesicles.
Neurotransmitter transporter
Glutamate transporter
Norepinephrine transporter
Vesicular monoamine transporter
Cyclic nucleotide–gated ion channel
Vesicular monoamine transporter 1
Voltage-gated ion channel
Mechanosensitive channels