<unk>  is synthesized from 1-benzyl-3-carbethoxypiperidin-4-one, which is reacted with o-phenylenediamine. Evidently, the first derivative that is formed under the reaction conditions, 1,5-benzodiazepine, rearranges into 1-(1-benzyl-1,2,3,6-tetrahydro-4-piridyl)-2-benzymidazolone. Debenzylation of the resulting product with hydrogen over a palladium catalyst, and subsequent alkylation of this using 4-chloro-4'-fluorobutyrophenone yields<unk> . 600px *C. Janssen, NV Res. Lab., (1962). *Janssen, P. A. J.; 1963, Belgian Patent . *F.J. Gardocki, J. Janssen, (1964). *P.A.J. Janssen, (1964). (See pimozide article for proposed mechanism of intramolecular rearrangement.)
Droperidol
Tianeptine
Tilorone
Iobitridol
Cidoxepin
Tripelennamine
Clorotepine
Desomorphine