No treatment is required, but neoplastic processes (metastatic malignancy to the submandibular lymph nodes and/or salivary gland tumours) should be ruled out. This is usually done with clinical exam and imaging. Very rarely, since the defect contains salivary gland tissue, salivary gland tumors can occur within an established defect but there is likely no difference in the risk of neoplasia in salivary gland tissue at other sites.
Stafne defect
Keyhole defect
Double aortic arch
Situs ambiguus
First arch syndrome
Pulmonary hypoplasia
Pulmonary agenesis
Pulmonary atresia