Bile acid sequestrants such as<unk>  were first used to treat hypercholesterolemia, but since the introduction of statins, now have only a minor role for this indication. They can also be used to treat the pruritus, or itching, that often occurs during liver failure and other types of cholestasis where the ability to eliminate bile acids is reduced.<unk>  is commonly used to treat diarrhea resulting from bile acid malabsorption. It was first used for this in Crohn's disease patients who had undergone ileal resection. The terminal portion of the small bowel (ileum) is where bile acids are reabsorbed. When this section is removed, the bile acids pass into the large bowel and cause diarrhea due to stimulation of chloride/fluid secretion by the colonocytes resulting in a secretory diarrhea.<unk>  prevents this increase in water by making the bile acids insoluble and osmotically inactive.<unk>  is also used in the control of other types of bile acid diarrhea. The primary, idiopathic form of bile acid diarrhea is a common cause of chronic functional diarrhea, often misdiagnosed as diarrhea-predominant irritable bowel syndrome (IBS-D), and most of these patients respond to<unk> . It is beneficial in the treatment of postcholecystectomy syndrome chronic diarrhea.<unk>  is also useful in treating post-vagotomy diarrhea.<unk>  can be helpful in the treatment of Clostridium difficile infections, to absorb toxins A and B, and reduce the diarrhea and the other symptoms these toxins cause. However, because it is not an anti-infective, it is used in concert with vancomycin. It is also used in the "wash out" procedure in patients taking leflunomide or teriflunomide to aid drug elimination in the case of drug discontinuation due to severe side effects caused by leflunomide or teriflunomide. A case report suggests that<unk>  may be useful for cyanobacterial (microcystin) poisoning in dogs. Ointments containing<unk>  compounded with aquaphor have been used in topical treatment of diaper rash in infants and toddlers.<unk>  also binds with oxalate in the GI tract, ultimately reducing urine oxalate and calcium oxalate stone formation.
Colestyramine
Ioxaglic acid
Tegaserod
Roxatidine acetate
Ingenol mebutate
Dimethyl fumarate
Cimetidine
Degmacyte