<unk>  is not used as a primary drug for treating hypertension because it elicits a reflex sympathetic stimulation of the heart (the baroreceptor reflex). The sympathetic stimulation may increase heart rate and cardiac output, and in people with coronary artery disease may cause angina pectoris or myocardial infarction.<unk>  may also increase plasma renin concentration, resulting in fluid retention. To prevent these undesirable side effects,<unk>  is usually prescribed in combination with a beta blocker (e.g., propranolol) and a diuretic. Beta-blockers licensed to treat heart failure in the UK include bisoprolol, carvedilol, and nebivolol.<unk>  is used to treat severe hypertension, but is not a first-line therapy for essential hypertension.<unk>  is often used to treat hypertension in pregnancy, though, with either labetalol and/or methyldopa.<unk>  is commonly used in combination with isosorbide dinitrate for the treatment of congestive heart failure in self-identified African-American populations. This preparation, isosorbide dinitrate/hydralazine, was the first race-based prescription drug. It should not be used in people who have tachycardia, heart failure, constrictive pericarditis, lupus, a dissecting aortic aneurysm, or porphyria.
Hydralazine
Captopril
Chlorothiazide
Cyclothiazide
Furosemide
Metoprolol
Hydrochlorothiazide
Nebivolol