<unk>  (VDWS) is a genetic disorder characterized by the combination of lower lip pits, cleft lip with or without cleft palate (CL/P), and cleft palate only (CPO). The frequency of orofacial clefts ranges from 1:1000 to 1:500 births worldwide, and there are more than 400 syndromes that involve CL/P.<unk>  is distinct from other clefting syndromes due to the combination of cleft lip and palate (CLP) and CPO within the same family. Other features frequently associated with<unk>  include hypodontia in 10-81% of cases, narrow arched palate, congenital heart disease, heart murmur and cerebral abnormalities, syndactyly of the hands, polythelia, ankyloglossia, and adhesions between the upper and lower gum pads. The association between lower lip pits and cleft lip and/or palate was first described by Anne Van<unk><unk>  in 1954. The worldwide disease incidence ranges from 1:100,000 to 1:40,000.
Van der Woude syndrome
Helsmoortel-Van der Aa syndrome
Van Den Bosch syndrome
Koolen–De Vries syndrome
Van Wyk and Grumbach syndrome
Wildervanck syndrome
Van Gogh syndrome
Nezelof syndrome