The most common types of high grade non-Hodgkin lymphoma are: Diffuse large B-cell Lymphoma (DLBCL) Diffuse large B cell lymphoma (DLBCL) is a type of high-grade NHL which is the most common type of NHL worldwide at affecting 30-40 percent of all NHL cases. It is more prevalent in elderly patients with a median age of 70 years. Patients most often present with a rapidly growing tumor mass in single or multiple, nodal or extranodal sites. The most commonly diagnosed versions of DLBCL are germinal center B-cell like (GCB) and activated B-cell like (ABC) subtypes. Immunohistochemical and flow cytometry analysis is also necessary for the diagnosis of this disease. The DLBCL cells have found to express B-cell antigens such as CD19, CD20, and CD22 as well as the transcription factors PAX5, BOB.1, and OCT2. CD20 is especially relevant in diagnostics as well as therapeutics because it is the target of the Rituximab humanized monoclonal antibody that is used in the most common treatment strategy. In addition to this, the majority of cells also express surface or cytoplasmic immunoglobulins, specifically IgM, IgG and IgA. While these analyses allow for diagnosis by displaying proof of B-cell lineage, they can also be used in treatment strategy and can give insight into prognosis of the specific case being considered. Burkitt Lymphoma Burkitt Lymphoma Burkitt lymphoma is named after the British surgeon Denis Burkitt. Dr.Burkitt identified this disease in 1956 in children in Africa. In Africa, Burkitt lymphoma is common in children also infected by malaria and Epstein-Barr virus. Outside of Africa, Burkitt lymphoma is less common. In the U.S., about 1,200 people are diagnosed each year, and the disease disproportionately affects those younger than the age of 40. Burkitt lymphoma is especially likely to develop in people infected with HIV, the virus that causes AIDS. Before highly active antiretroviral therapy (HAART) became a widespread treatment for HIV/AIDS, the incidence of Burkitt lymphoma was estimated to be 1,000 times higher in HIV-positive people than in the general population. Peripheral T-cell lymphoma Peripheral T-cell lymphomas are less common accounting for approximately 7% of all non-Hodgkin lymphoma cases. It represents a diverse group of diseases that lacks clear definition. These diseases may involve extranodal sites such as the liver, bone, marrow, intestinal tract and the skin. Due to its difficulties in classification, diagnosis and treatment is often regarded as "orphan diseases". Rarer types of high grade non-Hodgkin lymphoma * AIDS-associated lymphoma * Angioimmunoblastic lymphoma * Central nervous system (CNS) lymphoma * Mantle cell lymphoma (MCL)
Aggressive lymphoma
Indolent lymphoma
AIDS-related lymphoma
Gray zone lymphoma
Hodgkin lymphoma
Non-Hodgkin lymphoma
Mixed-cell lymphoma
Follicular lymphoma