In neuropsychopharmacology,<unk>  also known as decoupling, is the process of receptor- or ligand-binding sites or domains becoming separated, moving alignments and/or becoming internalised as a result of drug tolerance resulting from prolonged exposure to bioavailable psychoactive substances or toxins.
Uncoupling 
Spin–lattice relaxation
Flagging 
ConFusion
Deletion 
Stabilization 
Hydrolysis
Involution 