EES, also known as<unk>  3-isopropylsulfonate or<unk>  3-(2-propanesulfonate), is a synthetic estrane steroid and a derivative of estradiol. Specifically, it is the C3 isopropylsulfonate ester of<unk>  (17α-ethynylestradiol). EES is similar to quinestrol (EE 3-cyclopentyl ether), which is a C3 ether of EE and is a long-lasting oral depot estrogen similarly. Analogues of EES include<unk>  N,N-diethylsulfamate (J271) and<unk>  pyrrolidinosulfamate (J272). These analogues are rapidly taken up by erythrocytes in the blood of the hepatic portal vein during the first pass with oral administration, and have been found to be much stronger oral estrogens than EE or EES. EE and EES themselves do not have affinity for erythrocytes. EES and related C3 sulfur-containing esters of EE led to the development of estrogen sulfamates like estradiol 3-sulfamate (J995), estriol 3-sulfamate (J1034), and estradiol 17β-(1-(4-(aminosulfonyl)benzoyl)-L-proline) (EC508), which are highly potent oral estradiol prodrugs that bind to erythrocytes similarly and are under investigation for potential clinical use.
Ethinylestradiol sulfonate
Ethinylestradiol sulfate
Lipoidal estradiol
Desoxymethyltestosterone
Hexestrol diacetate
Hydroxyestrone diacetate
Hexestrol dipropionate
Cloxestradiol acetate