The diagnosis of<unk>  is usually made after an incidental finding of a low platelet count on a blood test or because of bleeding complications ranging from bruising or petechiae to intracranial hemorrhage in the fetus or newborn. Frequently, the reduction in platelet count is mild and the affected neonates remain largely asymptomatic.<unk>  is the commonest cause of a very low platelet count, and the commonest cause of intracranial haemorrhage in the term neonate. In case of severe thrombocytopenia, the neonates may exhibit bleeding complications at or a few hours after delivery. The most serious complication is intracranial hemorrhage, leading to death in approximately 10% of symptomatic babies or neurologic sequelae in 20% of cases. 80% of intracranial hemorrhages occur before birth. After birth the greatest risk of bleeding is in the first four days of life. Related conditions Immune thrombocytopenic purpura (), sometimes called idiopathic thrombocytopenic purpura is a condition in which autoantibodies are directed against a patient's own platelets, causing platelet destruction and thrombocytopenia. Anti-platelet autoantibodies in a pregnant woman with immune thrombocytopenic purpura will attack the patient's own platelets and will also cross the placenta and react against fetal platelets. Therefore, is a significant cause of fetal and<unk>  immune thrombocytopenia. Approximately 10% of newborns affected by will have platelet counts −1 and 1% to 2% will have a risk of intracerebral hemorrhage comparable to infants with . Mothers with thrombocytopenia or a previous diagnosis of should be tested for serum anti-platelet antibodies. A woman with symptomatic thrombocytopenia and an identifiable anti-platelet antibody should be started on therapy for their which may include steroids or . Fetal blood analysis to determine the platelet count is not generally performed as -induced thrombocytopenia in the fetus is generally less severe than . Platelet transfusions may be performed in newborns, depending on the degree of thrombocytopenia. Other conditions causing a low platelet count Other conditions that can cause a low platelet count in the neonate include bacterial and viral infection, disseminated intravascular coagulation and other rare congenital conditions associated with a low platelet count.
Neonatal alloimmune thrombocytopenia
Gestational thrombocytopenia
X linked thrombocytopenia
Quebec platelet disorder
Congenital amegakaryocytic thrombocytopenia
Gray platelet syndrome
Severe fever with thrombocytopenia syndrome
Harris platelet syndrome