* Pioglitazone is a member of the thiazolidinedione class, it decreases insulin resistance in the periphery and in the liver resulting in increased insulin dependent glucose disposal and decreased hepatic glucose output. * Metformin is a member of the biguanide class, improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.
Pioglitazone/metformin
Glibenclamide/metformin
Insulin degludec/liraglutide
Canagliflozin/metformin
Pioglitazone/glimepiride
Vildagliptin/metformin
Sitagliptin/metformin
Empagliflozin/metformin