<unk>  is a synthetic, nonsteroidal, highly selective agonist of ERβ. It possesses 68-fold selectivity for ERβ over ERα (EC50 = 2 nM and 155 nM, respectively).<unk>  has been found to enhance serotonergic and dopaminergic neurotransmission in the central nervous system, and produces antidepressant- and anxiolytic-like effects in animals. It has been proposed as a potential novel antidepressant/anxiolytic agent.<unk>  has also been found to produce antidiabetic effects in animals, and may also be beneficial for the treatment of certain inflammatory conditions. Due to its selectivity for ERβ,<unk>  is inactive in various assays of classic estrogen action, such as uterotrophic and osteopenia. Moreover,<unk>  does not affect luteinizing hormone or follicle-stimulating hormone or inhibit ovulation, indicating that it does not suppress the hypothalamic-pituitary-gonadal axis, and as ERα and not ERβ is implicated in breast development, would not be expected to cause growth of the breasts at doses that are selective for activation of ERβ. In fact, ERβ activation may actually suppress breast growth, and in accordance with this,<unk>  was shown to augment the efficacy of tamoxifen in in vitro models of breast cancer. As such,<unk>  and other selective ERβ agonists might prove to be safe and tolerable for medical use in both premenopausal and postmenopausal women and in individuals of either sex.
WAY-200070
WAY-267464
ICI-85966
WAY-166818
ICES
WAY-214156
QTY Code
DirectHit