<unk>  is used for the treatment of active duodenal ulcers not related to the use of nonsteroidal anti-inflammatory drugs (NSAIDs), as the mechanism behind these ulcers is due to acid oversecretion. It is not FDA approved for gastric ulcers, but is widely used because of evidence of efficacy. The use for<unk>  in peptic ulcer disease has diminished recently, but it is still the preferred agent for stress ulcer prevention.<unk>  has also been used for the following conditions: * Active duodenal ulcer not related to NSAID use * Maintenance therapy for resolved duodenal ulcers * Gastric ulcer not related to NSAID use and gastritis due to GERD—Triple combination therapy with lansoprazole + cisapride +<unk>  can significantly improve symptoms and quality of life and was more cost-effective than ranitidine combination group. * Aphthous ulcer and stomatitis due to radiation or chemotherapy—The 2013 guidelines of the International Society of Oral Oncology does not recommended<unk>  for the prevention of oral mucositis in head and neck cancer patients receiving radiotherapy or chemoradiation due to a lack of efficacy found in a randomized controlled trial. * Gastro-esophageal reflux disease during pregnancy—First-line drug therapy combined with lifestyle and diet modification. * Stress ulcer prophylaxis—The use of<unk>  rather than H2 antagonists for stress ulcer prophylaxis, and measures to prevent aspiration, such as continuous subglottic suctioning, have been shown to reduce the risk of ventilator-associated pneumonia (VAP).<unk>  is less effective for prophylaxis against gastrointestinal bleeding than either a PPI or H2-blocker. For that reason, it is not commonly used for stress ulcer prophylaxis. * Prevention of stricture formation—Sucralfate has an inhibitory effect on stricture formation in experimental corrosive burns and can be used in the treatment of corrosive esophageal burns to enhance mucosal healing and suppress stricture formation * Proctitis from ulcerative colitis * Rectal bleeding due to proctitis from radiation to treat cancers of the cervix, prostate, and colon. * Grade 1 bleeding experienced immediate relief with sucrasulfate enema for 1 month. * Grade 2 bleeding, sucrasulfate enema and/or coagulation were effective. * Grade 3 bleeding lasted for 1 year despite frequent transfusions and coagulation. * Grade 2 and 3 rectal bleeding occurred in 8.5% of people. The most significant risk factor was the ICRU-CRBED. Prompt treatment with a combination of sucrasulfate enema and coagulation is effective in controlling Grade 1 and 2 rectal bleeding without the development of fistula or stricture. * Treatment of anastomotic ulcer after gastric bypass surgery *<unk>  suspension is recommended by the US-based National Capital Poison Center (Poison Control) as an intervention for known or suspected button battery ingestions to reduce the risk and severity of injury to the esophagus prior to the battery's endoscopic removal. *Protection against ventilator-associated pneumonia - Reductions in gastric acidity and volumes increase bacterial overgrowth and the incidence of ventilator-associated pneumonia.<unk>  may be considered to have the advantage over H2-blockers and PPIs in this regard because<unk>  does not change the pH of gastric fluid. A majority of meta-analyses found that<unk>  therapy decreased the incidence of ventilator-associated pneumonia compared to H2-antagonists.
Sucralfate
Cimetidine
Dexlansoprazole
Lansoprazole
Azacitidine
Ranitidine
Loperamide
Rabeprazole