<unk>  are used in addition to changes in diet to reduce triglyceride levels in adults with severe (≥ 500 mg/dL) hypertriglyceridemia. Intake of large doses (2.0 to 4.0 g/day) of long-chain omega-3 fatty<unk>  as prescription drugs or dietary supplements are generally required to achieve significant (> 15%) lowering of triglycerides, and at those doses the effects can be significant (from 20% to 35% and even up to 45% in individuals with levels greater that 500 mg/dL). It appears that both eicosapentaenoic<unk> (EPA) and docosahexaenoic<unk> (DHA) lower triglycerides. However, DHA appears to raise LDL-C ("bad cholesterol") more than EPA, and further, DHA raises HDL-C ("good cholesterol") while EPA does not. Other fish-oil based drugs There are other omega-3 fish oil based drugs on the market that have similar uses and mechanisms of action. * Omega-3<unk> ethyl esters (brand names Omarcor or Lovaza, Omtryg, and as of March 2016, four generic versions). * Ethyl eicosapentaenoic<unk> (Vascepa, and 1 generic as ethyl icosapent) Dietary supplements There are many fish oil dietary supplements on the market. There appears to be little difference in effect between dietary supplement and prescription forms of omega-3 fatty<unk> . Importantly, EPA and DHA ethyl esters (prescription forms) work better when taken with a mildly-fattening meal of about 350 calories. The ingredients of dietary supplements are not as carefully controlled as prescription products and have not been fixed and tested in clinical trials, as prescription drugs have. Furthermore, the prescription forms are more concentrated, requiring fewer capsules to be taken and increasing the likelihood of compliance.
Omega-3 carboxylic acids
Omega-3 fatty acid
Omega-3 acid ethyl esters
Fish oil 
Fish oil
Omega-6 fatty acid
Dietary fiber
Cholic acid