The cell of origin for this disease is an immature cytotoxic T-cell clonally expressing the γδ T-cell receptor. The disease is seen more often in immunosuppressed recipients of solid organ transplants, an association that has led to the hypothesis that long-term immune stimulation in the setting of immunosuppression is the causative agent. Cases of<unk>  have been reported in patients treated with the immunosuppressants azathioprine, infliximab, and adalimumab. The majority of cases occurred in patients with inflammatory bowel disease. Adolescents and young adult males were most frequently affected. They presented with a very aggressive disease course, and all but one died. The Food and Drug Administration required changes to the drugs' labeling to inform users and clinicians of the risk.
Hepatosplenic T-cell lymphoma
Splenic marginal zone lymphoma
Splenic lymphoma with villous lymphocytes
AIDS-related lymphoma
Monomorphic epitheliotropic intestinal T cell lymphoma
Amoebic liver abscess
Nodal marginal zone B cell lymphoma
Acinar cell carcinoma of the pancreas