Neurologic signs and symptoms include progressively delayed development, weak muscle tone (hypotonia), seizures, and abnormal movements. The body's network of blood vessels is also affected. Children with this disorder may experience rashes of tiny red spots (petechiae) caused by bleeding under the skin and blue discoloration in the hands and feet due to reduced oxygen in the blood (acrocyanosis). Chronic diarrhea is another common feature of<unk> . EE is often identified by urine organic acid analysis, the excretion of<unk>  acid, methylsuccinic acid, isobutyrylglycine and isovalerylglucine. Patients will also often have elevated thiosulphate concentration in their urine. The signs and symptoms of<unk>  are apparent at birth or begin in the first few months of life. Problems with the nervous system typically worsen over time, and most affected individuals survive only into early childhood. A few children with a milder, chronic form of this disorder have been reported, and there can be considerable phenotypic variation, even within families. The life expectancy of individuals with EE is less than ten years.
Ethylmalonic encephalopathy
Glycine encephalopathy
Toxic encephalopathy
Wernicke encephalopathy
Early myoclonic encephalopathy
Autoimmune encephalitis
Powassan encephalitis
Viral encephalitis