<unk>  has a number of visible symptoms. Most important clinical features are: pachydermia (thickening and wrinkling of the skin), furrowing of the face and scalp, periostosis (swelling of periarticular tissue and shaggy periosteal new bone formation of long bones) and digital clubbing (enlargement of fingertips). Other features include excessive sweating, arthralgia and gastrointestinal abnormalities. An overview of all symptoms is provided in table 2. Table 2. Overview of symptoms Skin features Pachydermia Coarse skin Oily skin Eczema Thick hand and foot skin Leonine facies Furrowing Cutis verticis gyrate Increased secretion of sebum Sebborheic hyperplasia Keloid formation Bone features Periostosis Acroosteolysis Mylefibrosis Thick toe and finger bones Widening of bone formation Clubbing Digital clubbing Sweating Hyperhidrosis Eye features Drooping eyelids Thick stratum corneum Joints Arthralgia Joint effusion Muscles Muscle discomfort Hair Decreased facial and pubic hair Vascular Peripheral vascular stasis Gastrointestinal involvement Peptic ulcer Chronic gastritis Crohn’s disease
Pachydermoperiostosis
Acromegaly
Craniosynostosis
Melorheostosis
Buccal exostosis
Subungual exostosis
Achondroplasia
Pseudoachondroplasia