It is characterized by variable reductions in serum immunoglobulin levels which cause most ICF patients to succumb to infectious diseases before adulthood. ICF syndrome patients exhibit<unk><unk>  which include hypertelorism, low-set ears, epicanthal folds and macroglossia.
Immunodeficiency–centromeric instability–facial anomalies syndrome
Cerebral dysgenesis–neuropathy–ichthyosis–keratoderma syndrome
Ectrodactyly–ectodermal dysplasia–cleft syndrome
SAPHO syndrome
Kabuki syndrome
Orofaciodigital syndrome
Combined immunodeficiencies
Chromosome instability syndrome