The diagnosis of<unk>  is merely descriptive and is not a disease in itself, nor does it describe the underlying cause of the brain malformation.<unk>  may be just one piece of a syndrome of developmental abnormalities, because children born with it may suffer from a wide spectrum of other problems, including global developmental disabilities, mild to severe intellectual disabilities, motor dysfunctions including speech and swallowing problems, respiratory problems, seizures. Though it is difficult to make a predictable prognosis for children with the diagnosis of<unk> , there are some generalized clinical findings according to the areas of the brain that are affected. * Bilateral frontal<unk>  (BFP) – Cognitive and motor delay, spastic quadriparesis, epilepsy * Bilateral frontoparietal<unk>  (BFPP) – Severe cognitive and motor delay, seizures, dysconjugate gaze, cerebellar dysfunction * Bilateral perisylvian<unk>  (BPP) – Pseudobulbar signs, cognitive impairment, epilepsy, some with arthrogryposis or lower motor neuron disease * Bilateral parasagittal parieto-occipital<unk>  (BPPP) – Partial seizures, some with intellectual developmental disorder * Bilateral generalized<unk>  (BGP) – Cognitive and motor delay of variable severity, seizures Rates of symptoms in<unk>  include 78% for epilepsy, 70% for global developmental delay, 51% for spasticity, 50% for microcephaly, 45% for dysmorphic features (e.g., abnormal facies or hand, feet, or digital anomalies), and 5% for macrocephaly. In the BPP subtype of<unk> , up to 75% may have mild to moderate intellectual disability.
Polymicrogyria
Geographic atrophy
Posterior cortical atrophy
Coprolalia
Neurofibrillary tangle
Argyria
Hypermastigia
Fibular hemimelia