As a syndrome, this condition is poorly defined. Diagnostic criteria require one or more<unk>  antibodies (which target tRNA synthetase enzymes), and one or more of the following three clinical features: interstitial lung disease, inflammatory myopathy, and inflammatory polyarthritis affecting small joints symmetrically. Other supporting features may include fever, Raynaud's phenomenon and "mechanics hands"-thick, cracked skin usually on the palms and radial surfaces of the digits. The disease, rare as it is, is more prevalent in women than in men. Early diagnosis is difficult, and milder cases may not be detected. Also, interstitial lung disease may be the only manifestation of the disease. Severe disease may develop over time, with intermittent relapses.
Antisynthetase syndrome
CREST syndrome
Mixed connective tissue disease
Anti-IgLON5 disease
TNF receptor associated periodic syndrome
Auto-brewery syndrome
Cryopyrin-associated periodic syndrome
Mast cell activation syndrome