The diagnosis of<unk>  is based on observed phenotypic features and confirmed by histological examination of the kidneys. Prenatal diagnosis is possible for families that have a genetic disposition for<unk>  although there is no conclusive laboratory test to confirm the diagnosis. Fetal overgrowth, particularly with an occipitofrontal circumference (OFC) greater than the 90th centile for gestational age, as well as an excess of amniotic fluid in the amniotic sac (polyhydramnios), may be the first signs of<unk> . Using ultrasound diagnosis,<unk>  has been detected at 18 weeks. During the first trimester, the common abnormalities of the syndrome observed by ultrasound include cystic hygroma and a thickened nuchal lucency. Common findings for the second and third trimesters include macrosomia, enlarged kidneys, renal tumors (both hamartoma and Wilms), cardiac abnormalities and visceromegaly. Prompt recognition and identification of the disorder along with accurate follow-up and clinical assistance is recommended as the prognosis for<unk>  is severe and associated with a high neonatal death rate. Differential diagnosis<unk>  shares clinical overlaps with other overgrowth disorders, with similarities to Beckwith–Wiedemann syndrome and Simpson-Golabi-Behmel syndrome having been particularly emphasized in scientific study. Similarities with Beckwith-Wiedemann syndrome include polyhydramnios, macrosomia, nephromegaly and hypoglycaemia. It is the distinctive facial dysmorphology of<unk> , including deep-set eyes, depressed nasal bridge, everted upper lip, and macrocephaly which allows the two conditions to be distinguished from one another. Diagnosis of<unk>  also overlaps with other disorders associated with Wilms tumor, namely, Sotos syndrome and Weaver syndrome.
Perlman syndrome
Trotter's syndrome
Gitelman syndrome
Ortner's syndrome
FG syndrome
Angelman syndrome
Hamman's syndrome
Muir–Torre syndrome