In clinical trials, people treated with the highest dose of<unk>  ER in combination with a program of diet and exercise lost 10% to 11% of their body weight compared to 1% to 2% for those who received placebo. In addition, 62% to 70% of subjects receiving the recommended dose or top dose of<unk>  ER achieved ≥5% weight reduction by week 56 (ITT-LOCF) compared to 17% to 21% of those receiving a placebo. A Cochrane review on the long-term effects of weight-reducing drugs on people with hypertension found that<unk>  reduced body weight (when compared to orlistat, and naltrexone/bupropion) and also reduced blood pressure.
Phentermine/topiramate
Brinzolamide/brimonidine
Brimonidine/timolol
Zonisamide
Topiramate
Amitriptyline/chlordiazepoxide
Primidone
Valproate pivoxil