Effectiveness A 2009 review estimated that<unk> tion against<unk>  would prevent about 45% of deaths due to<unk>  gastroenteritis, or about 228,000 deaths annually worldwide. At US$5 per dose, the estimated cost per life saved was $3,015, $9,951 and $11,296 in low-, lower-middle-, and upper-middle-income countries, respectively. Safety and efficacy trials in Africa and Asia found that the<unk> s dramatically reduced severe disease among infants in developing countries, where a majority of<unk> -related deaths occur. A 2019 Cochrane review concluded that RV1, RV5, and Rotavac<unk> s are safe and are effective at preventing diarrhea.<unk> s are licensed in more than 100 countries, and more than 80 countries have introduced routine<unk> tion. The incidence and severity of<unk>  infections has declined significantly in countries that have acted on the recommendation to introduce the<unk> . In Mexico, which in 2006 was among the first countries in the world to introduce<unk> , the diarrheal disease death rates from<unk>  dropped by more than 65% among children age two and under during the 2009<unk>  season. In Nicaragua, which in 2006 became the first developing country to introduce the<unk> , investigators recorded a substantial impact, with<unk>  preventing 60% of cases against severe<unk>  and cutting emergency room visits in half. In the United States,<unk> tion has reduced<unk> -related hospitalizations by as much as 86% since 2006. In April 2016, the World Health Organization released statistics for the period of 2000–2013, which showed developing countries that have introduced<unk> s experienced significant decreases in deaths and hospitalizations from<unk>  diarrhea after introduction. Additionally, the<unk> s may also prevent illness in non-vaccinated children by limiting exposure through the number of circulating infections. A 2014 review of available clinical trial data from countries routinely using<unk> s in their national immunization programs found that<unk> s have reduced<unk>  hospitalizations by 49–92% and all-cause diarrhea hospitalizations by 17–55%. Schedule The World Health Organization recommends the first dose of<unk>  be given right after six weeks of age.
Rotavirus vaccine
Lactobacillus vaccine
Brucellosis vaccine
Adenovirus vaccine
Hantavirus vaccine
Measles vaccine
Anthrax vaccines
Varicella vaccine