Early symptoms of an arterial embolism in the arms or legs appear as soon as there is ischemia of the tissue, even before any frank<unk>  has begun. Such symptoms may include: A major presentation of diabetic skeletal muscle<unk>  is painful thigh or leg swelling. Affected tissues The major tissues affected are nerves and muscles, where irreversible damage starts to occur after 4–6 hours of cessation of blood supply. Skeletal muscle, the major tissue affected, is still relatively resistant to<unk>  compared to the heart and brain because its ability to rely on anaerobic metabolism by glycogen stored in the cells may supply the muscle tissue long enough for any clot to dissolve, either by intervention or the body's own system for thrombus breakdown. In contrast, brain tissue (in cerebral<unk>  does not store glycogen, and the heart (in myocardial<unk>  is so specialized on aerobic metabolism that not enough energy can be liberated by lactate production to sustain its needs. Bone is more susceptible to ischemia, with hematopoietic cells usually dying within 2 hours, and other bone cells (osteocytes, osteoclasts, osteoblasts etc.) within 12–20 hours. On the other hand, it has better regenerative capacity once blood supply is reestablished, as the remaining dead inorganic osseous tissue forms a framework upon which immigrating cells can reestablish functional bone tissue in optimal conditions.
Limb infarction
Flail limb
Burn
Burn 
Tendon rupture
Malunion
Spinal fracture
Bone fracture