<unk> plasma concentrations are known to be increased with concurrent use of diuretics—especially loop diuretics (such as furosemide) and thiazides—and non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen.<unk> concentrations can also be increased with concurrent use of ACE inhibitors such as captopril, enalapril, and lisinopril.<unk> is primarily cleared from the body through glomerular filtration, but some is then reabsorbed together with sodium through the proximal tubule. Its levels are therefore sensitive to water and electrolyte balance. Diuretics act by lowering water and sodium levels; this causes more reabsorption of<unk> in the proximal tubules so that the removal of<unk> from the body is less, leading to increased blood levels of<unk>  ACE inhibitors have also been shown in a retrospective case-control study to increase<unk> concentrations. This is likely due to constriction of the afferent arteriole of the glomerulus, resulting in decreased glomerular filtration rate and clearance. Another possible mechanism is that ACE inhibitors can lead to a decrease in sodium and water. This will increase<unk> reabsorption and its concentrations in the body. There are also drugs that can increase the clearance of<unk> from the body, which can result in decreased<unk> levels in the blood. These drugs include theophylline, caffeine, and acetazolamide. Additionally, increasing dietary sodium intake may also reduce<unk> levels by prompting the kidneys to excrete more<unk> <unk> is known to be a potential precipitant of serotonin syndrome in people concurrently on serotonergic medications such as antidepressants, buspirone and certain opioids such as pethidine (meperidine), tramadol, oxycodone, fentanyl and others.<unk> co-treatment is also a risk factor for neuroleptic malignant syndrome in people on antipsychotics and other antidopaminergic medications. High doses of haloperidol, fluphenazine, or flupenthixol may be hazardous when used with<unk>  irreversible toxic encephalopathy has been reported. Indeed, these and other antipsychotics have been associated with increased risk of<unk> neurotoxicity, even with low therapeutic<unk> doses.
Lithium 
Chlortalidone
Methylphenidate
Sertraline
Citalopram
Paliperidone
Loprazolam
Dexmethylphenidate