The most representative criterion for diagnose of<unk>  is autoimmune enteropathy. First symptoms of enteropathy begin in first day of life and they are characterized by diarrhea, vomiting, gastritis, ileus and colitis. The second hallmark is type 1 diabetes (T1D) and the worst complication of it is destruction of pancreas confirmed by histological examinations. Dermatitis is next sign and it can be presented in three forms: eczematiform (mainly atopic dermatitis), ichthyosiform and psoriasiform or combinations of them. Other skin manifestations can include cheilitis, onychodystrophy and alopecia. Beside the three most significant triada of symptoms during this syndrom other not so typical symptoms include: thyroid and renal dysfunction, reduced counts of thrombocytes and neutrophils, arthritis, splenomegaly, lymphadenopathy and infections. Family history of<unk>  patients<unk>  patients are usually born with normal weight and length at term. Nevertheless, the first symptoms may present in the first days of life, and some reported cases labeled newborns with intrauterine growth retardation and evidence of meconium in the amniotic fluid. Triad of symptoms Eczema A serious course of the disease is marked by a triad of symptoms: intractable diarrhea, T1D, and eczema. Clinical manifestations include: enteropathy, skin manifestations, endocrinopathy, hematologic abnormalities, infections, autoimmune hemolytic anemia and food allergy.
IPEX syndrome
EAST syndrome
TAN syndrome
TEMPI syndrome
SUNCT syndrome
VEXAS syndrome
3C syndrome
RIDDLE syndrome