Skeletal formula of azumolene. The bromine atom replacing the nitro group found in<unk>  may be seen at left. Chemically it is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin. The poor water solubility of<unk>  leads to certain difficulties in its use. A more water-soluble analog of<unk> , azumolene, is under development for similar indications. Azumolene has a bromine residue instead of the nitro group found in<unk> , and is 30 times more water-soluble. Synthesis The original patent synthesis started with para-nitroaniline which undergoes diazotization followed by a copper(II) chloride catalyzed arylation with furfural (essentially a modified Meerwein arylation). This then reacts with 1-aminohydantoin to form the final product. Norwich Pharma Co).
Dantrolene
Atogepant
Seltorexant
Clorotepine
Dezocine
Cidoxepin
Bocasan
Lemborexant