In<unk>  patients, gradual cyst development and expansion result in<unk>  enlargement, and during the course of the disease, glomerular filtration rate remains normal for decades before<unk>  function starts to progressively deteriorate, making early prediction of renal outcome difficult. The CRISP study, mentioned in the treatment section above, contributed to build a strong rationale supporting the prognostic value of total<unk>  volume (TKV) in<unk> ; TKV (evaluated by MRI) increases steadily and a higher rate of<unk>  enlargement correlated with accelerated decline of GFR, while patient height-adjusted TKV (HtTKV) ≥600 ml/m predicts the development of stage 3 chronic<unk>  disease within 8 years. Besides TKV and HtTKV, the estimated glomerular filtration rate (eGFR) has also been tentatively used to predict the progression of<unk> . After the analysis of CT or MRI scans of 590 patients with<unk>  treated at the Mayo Translational<unk><unk>  Disease Center, Irazabal and colleagues developed an imaging-based classification system to predict the rate of eGFR decline in patients with<unk> . In this prognostic method, patients are divided into five subclasses of estimated<unk>  growth rates according to age-specific HtTKV ranges (1A, 6.0%) as delineated in the CRISP study. The decline in eGFR over the years following initial TKV measurement is significantly different between all five patient subclasses, with those in subclass 1E having the most rapid decline. Some of the most common causes of death in patients with<unk>  are various infections (25%), a ruptured berry aneurysm (15%), or coronary/hypertensive heart disease (40%).
Autosomal dominant polycystic kidney disease
Autosomal recessive polycystic kidney disease
Medullary cystic kidney disease
Glomerulocystic kidney disease
Medullary sponge kidney
Juvenile nephronophthisis
Horseshoe kidney
Multicystic dysplastic kidney