<unk> s are a class of small molecules that antagonize the<unk>  receptor. The C-C motif chemokine receptor<unk>  is involved in the process by which HIV, the virus that causes AIDS, enters cells. Hence<unk> s of this receptor are entry inhibitors and have potential therapeutic applications in the treatment of HIV infections. The life cycle of the HIV presents potential targets for drug therapy, one of them being the viral entry pathway.<unk>  and CXCR4 are the main receptors involved in the HIV entry process. These receptors belong to the seven transmembrane G-protein-coupled receptor (GPCR) family and are predominantly expressed on human T-cells, dendritic cells and macrophages, Langerhans cells. They play an important role as co-receptors that HIV type 1 (HIV-1) uses to attach to cells before viral fusion and entry into host cells. HIV isolates can be divided into R5 and X4 strains. R5 strain is when the virus uses the co-receptor<unk>  and X4 strain is when it uses CXCR4. The location of<unk>  receptors at the cell surface, both large and small molecules have the potential to interfere with the<unk> -viral interaction and inhibit viral entry into human cells.
CCR5 receptor antagonist
CXCR4 antagonist
Tissue factor pathway inhibitor
Protein kinase inhibitor
TNF inhibitor
C-Met inhibitor
COX-2 inhibitor
Growth factor receptor inhibitor