<unk>  exists as a solid at room temperature, with a melting point of 127 degrees C. The pair of ortho chlorine (Cl−) atoms on the phenyl ring are necessary for<unk> 's agonism at the α2a adrenergic receptor subtype; removal of either chlorine atom results in antagonism at the receptor. Comparison to clonidine Structure of clonidine and<unk> <unk>  is structurally analogous to clonidine, another α2 adrenergic receptor agonist used for treatment of opioid withdrawal symptoms. A comparison of the two structures is shown at right. Both contain an imidazoline ring and a 2,6-dichlorinated phenyl ring. The differences in structure are shown in red, while the similarities are in black. In addition to the structural differences, administration of<unk>  to people who abuse opioids has been shown to be more effective for a longer duration, with fewer withdrawal symptoms than clonidine even after one day. However, clonidine is often preferred as it is substantially cheaper than<unk>  when purchased with a private (non-NHS) prescription. This factor is exacerbated by the considerable number of and quantities of medications prescribed to alleviate the constellation of withdrawal signs and symptoms. Additionally, clonidine has been shown to significantly lower blood pressure. Therefore, although similar to<unk> , clonidine is most frequently prescribed to treat high blood pressure.
Lofexidine
Setiptiline
Pramocaine
Veratridine
Tocainide
Ivabradine
Nefopam
Procainamide