The lesion is found in patients who present typically with abnormal or postmenopausal bleeding or discharge. Such bleeding is followed by further evaluation leading to a tissue diagnosis, usually done by a dilatation and curettage (D&C). A work-up to follow would look for metastasis using imaging technology including sonography and MRI. The median age at diagnosis in a large study was 66 years. Histologically the lesion may coexist with classical endometrial cancer.
Uterine clear-cell carcinoma
Endometrial stromal sarcoma
Uterine adenosarcoma
Uterine serous carcinoma
Endometrial stromal tumour
Uterine sarcoma
Clear-cell ovarian carcinoma
Tubular carcinoma