A report in 2008 stated that, though there was no "comprehensive review since the 1950s" and "almost no legal clinical research" since the 1970s, there had been "no documented human deaths from an<unk>  overdose". Eight individuals who accidentally consumed very high amounts by mistaking<unk>  for cocaine developed comatose states, hyperthermia, vomiting, gastric bleeding, and respiratory problems—all survived, however, with supportive care. According to more recent reports, several behavioral-related fatalities and suicides have occurred due to<unk> . Reassurance in a calm, safe environment is beneficial. Agitation can be safely addressed with benzodiazepines such as lorazepam or diazepam. Neuroleptics such as haloperidol are not recommended because they may have adverse effects.<unk>  is rapidly absorbed, so activated charcoal and emptying of the stomach is of little benefit, unless done within 30–60 minutes of ingesting an overdose of<unk> . Sedation or physical restraint is rarely required, and excessive restraint may cause complications such as hyperthermia (over-heating) or rhabdomyolysis. Massive doses "should be treated with supportive care, including respiratory support and endotracheal intubation if needed. Hypertension high blood pressure, tachycardia rapid heart-beat, and hyperthermia should be treated symptomatically. Hypotension low blood pressure should be treated initially with fluids and subsequently with pressors if required." "Intravenous administration of anticoagulants, vasodilators, and sympatholytics may be useful" when treating ergotism.
Lysergic acid diethylamide
Brevetoxin
Anatoxin-a
Bungarotoxin
Botulinum toxin
Charybdotoxin
Muscimol
N1-Methyl-lysergic acid diethylamide