<unk> <unk> , a derivative of imidazothiazole, was previously approved as an antihelminthic and immunomodulator. It experienced some usage for the treatment of rheumatoid arthritis but was primarily used for the treatment of parasitic infections. It was withdrawn from the U.S. market in early 2000 because of adverse health events. However, it is still approved in the United States as an antihelminthic agent in veterinary medicine.<unk>  toxicity in cocaine supply<unk>  has become a common additive to illicit cocaine. It is thought to intensify the "high" by releasing dopamine in the brain, acts as a bulking agent, and is a difficult adulterant to recognize. Potential risks of<unk> -laced cocaine include neutropenia, agranulocytosis, arthralgias, retiform purpura, skin<unk> , and fever. The skin<unk>  associated with<unk>  toxicity ranges from leukocytoclastic vasculitis to occlusive vasculopathy. Several cases of severe agranulocytosis associated with cocaine use have been reported since 2006. With the recently recognized dermal disease, the face and ears are commonly affected, especially the bilateral helices and cheeks. However, there have also been case reports of involvement of the abdomen, chest, lower buttocks and legs.
Levamisole induced necrosis syndrome
Metal fume fever
Adult-onset Still's disease
Relapsing fever
Polymer fume fever
Papular purpuric gloves and socks syndrome
Milk sickness
Toxic shock syndrome