<unk> es can be used in a variety of medical and scientific manners, thus far been to treat cancer, Graves' disease, and prevent the growth of malaria in mosquitoes. Cancer treatment<unk> es have been used in clinical trials of cancer treatments. The<unk>  ipilimumab has been effectively used in the clinical treatment of melanoma, RCC, and NSCLC with some degree of success. This is accomplished through the<unk>  of the coinhibitory molecule CTLA-4. The<unk>  does not directly target tumor cells, but rather blocks the regulatory functions of CTLA-4, resulting in enhanced T-cell function. Some new treatments hypothesize the<unk>  of PD-1, a programmed cell-death protein, which will result in longer-lived T-cells. The<unk>  BMS-936559 has been shown to bind to PD-L1 and prevent its binding to PD-1. These new treatments are not without side-effects and irAEs (immune-related adverse events) have been observed in a variety of patients. The tolerance that immune cells normally have to host tissues can be lost, resulting in permanent damage to host cells. Graves' disease Studies have shown that<unk> es can bind to and prevent thyrotropin binding, resulting in reduced cAMP levels in human thyroid cells. This interaction has been used primarily as a method of indicating that Graves' disease immunoglobulins are pluritopic, meaning that they have multiple effects, rather than indicating a possible treatment for this disease. Malaria<unk> es have a variety of functions on the merozoite form of parasitic malaria. While in the merozoite form, malaria parasites invade erythrocytes and reproduce in them. Some<unk> es may inhibit the invasion of erythrocytes, while other<unk> es prevent the binding of inhibitory antibodies, allowing merozoite invasion of erythrocytes despite the presence of inhibitory antibodies. The monoclonal antibodies that prevent the invasion of merozoites bind to the parasitic antigen MSP-1 (merozoite surface protein 1). The binding of<unk> es to MSP-1 is shown to result in the inhibition of secondary processing, resulting in the inability for merozoites to invade host erythrocytes. Secondary processing involves a single proteolytic cleavage on the merozoite surface of the carboxy-terminal component of MSP-1. The<unk>  of MSP-1 has been proposed to be a method of creating a vaccine against malaria by preventing its invasion and multiplication.
Blocking antibody
Neutralizing antibody
Monoclonal antibody
Polyclonal antibodies
TNF inhibitor
Antibody opsonization
Fragment antigen-binding
Protective sequestration