<unk>  exerts its toxicity through excessive sedation, resulting in respiratory depression and ultimately death via hypoxia. Nonlethal overdoses may also result in coma and death. There is no specific antidote to barbiturate overdose; treatment is supportive, generally including the administration of intravenous saline, naloxone, thiamine, glucose, sodium bicarbonate to alkalize the urine and increase rate of excretion, and activated charcoal via nasogastric tube.<unk>  exerts its toxicity through the production of a toxic metabolite that can cause liver damage at doses as low as four grams. Larger doses can precipitate acute liver failure, acute kidney injury, or gastrointestinal bleeding; death has been known to occur with ingestion of ten to fifteen grams. The specific antidote to<unk>  overdose is N-acetylcysteine.
Butalbital/acetaminophen
Hydrocodone/paracetamol
Oxycodone/ibuprofen
Phenylephrine/ketorolac
Hydrocodone/ibuprofen
Naproxen/diphenhydramine
Hydrocodone/aspirin
Ibuprofen/paracetamol