<unk>  (also spelled<unk>  and pronounced ) is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. These blood cells are not fully developed and are called blasts or<unk>  cells. Symptoms may include bleeding and bruising, bone pain, fatigue, fever, and an increased risk of infections. These symptoms occur due to a lack of normal blood cells. Diagnosis is typically made by blood tests or bone marrow biopsy. The exact cause of<unk>  is unknown. A combination of genetic factors and environmental (non-inherited) factors are believed to play a role. Risk factors include smoking, ionizing radiation, some chemicals (such as benzene), prior chemotherapy, and Down syndrome. People with a family history of<unk>  are also at higher risk. There are four main types of<unk> —acute lymphoblastic<unk>  (ALL), acute myeloid<unk>  (AML), chronic lymphocytic<unk>  (CLL) and chronic myeloid<unk>  (CML)—as well as a number of less common types.<unk> s and lymphomas both belong to a broader group of tumors that affect the blood, bone marrow, and lymphoid system, known as tumors of the hematopoietic and lymphoid tissues. Treatment may involve some combination of chemotherapy, radiation therapy, targeted therapy, and bone marrow transplant, in addition to supportive care and palliative care as needed. Certain types of<unk>  may be managed with watchful waiting. The success of treatment depends on the type of<unk>  and the age of the person. Outcomes have improved in the developed world. Five-year survival rate is 65% in the United States. In children under 15, the five-year survival rate is greater than 60% or even 90%, depending on the type of<unk> . In children with acute<unk>  who are cancer-free after five years, the cancer is unlikely to return. In 2015,<unk>  was present in 2.3 million people worldwide and caused 353,500 deaths. In 2012 it newly developed in 352,000 people. It is the most common type of cancer in children, with three-quarters of<unk>  cases in children being the acute lymphoblastic type. However, over 90% of all<unk> s are diagnosed in adults, with CLL and AML being most common in adults. It occurs more commonly in the developed world.
Leukemia
Paracoccidioidomycosis
Pythiosis
Progressive vaccinia
Agranulocytosis
Granulocytosis
Acute leukemia
Leukopenia