Oral uptake of<unk>  is excellent. Its volume of distribution is 17.0-38.5L (whereas it is 8.5-9.3L for its active metabolite DHEA-S).<unk>  (DHEA) has a biological half-life of 15-38 min (whereas it is 7-22h for DHEA-S). 51-73% of DHEA-S and its metabolites are excreted via the renal route.Testosterone levels following a single oral dose of 300 mg crystalline (non-micronized) or micronized<unk>  (DHEA) in premenopausal women. Estradiol and levels after a single intramuscular injection of Gynodian Depot (4 mg estradiol valerate, 200 mg<unk>  enanthate) in women.<unk>  is metabolized into androgens and estrogens in the body, including androstenedione, testosterone, estrone, estradiol, and estriol. The transformation of<unk>  into androgens and estrogens is tissue-specific, for instance occurring in the liver, fat, vagina, prostate gland, skin, and hair follicles (as well as other tissues). Metabolism<unk>  is also reversibly transformed into its active metabolite<unk>  sulfate (DHEA-S) by steroid sulfotransferase (specifically SULT1E1 and SULT2A1), which in turn can be converted back into<unk>  by steroid sulfatase. Interconversion takes place in both adrenal and peripheral tissues. It is transformed into androstenedione by 3β-hydroxysteroid dehydrogenase (3β-HSD), and into androstenediol by 17β-hydroxysteroid dehydrogenase (17β-HSD). Then, androstenedione and androstenediol can be converted into testosterone by 17β-HSD and 3β-HSD, respectively. Subsequently, testosterone can be metabolized into dihydrotestosterone by 5α-reductase. In addition, androstenedione and testosterone can be converted into estrone and estradiol by aromatase, respectively. Dose-response of hormone levels At a high dosage of 1,600 mg/day orally for 4 weeks, treatment of postmenopausal women with<unk>  has been found to increase serum levels of DHEA by 15-fold, testosterone by 9-fold, DHEA-S, androstenedione, and DHT all by 20-fold, and estrone and estradiol both by 2-fold. Although<unk>  can reliably increase testosterone levels in women, this isn't similarly the case in men. A high dosage of 1,600 mg/day<unk>  in men for 4 weeks was found to increase DHEA and androstenedione levels but did not significantly affect testosterone levels. Dosing In clinical studies of<unk>  supplementation, dosages have ranged from 20 to 1,600 mg per day. In people with adrenal insufficiency, oral dosages of 20 to 50 mg/day<unk>  have been found to restore DHEA and DHEA-S levels to physiological levels seen in young healthy adults. Conversely, oral dosages of 100 to 200 mg/day<unk>  have been found to result in supraphysiological levels of DHEA and DHEA-S. Micronization of<unk>  has been found to significantly increase levels of DHEA-S achieved with oral administration, but to produce no significant change in levels of DHEA or testosterone levels achieved.
Prasterone
Chlordecone
Enoximone
Dipipanone
Azacyclonol
Methasterone
Iomeprol
Crotamiton