<unk>  is a protein kinase inhibitor with activity against many protein kinases, including VEGFR, PDGFR and RAF kinases. Of the RAF kinases,<unk>  is more selective for c-Raf than B-RAF. (See BRAF (gene)#Sorafenib for details the drug's interaction with B-Raf.)<unk>  treatment induces autophagy, which may suppress tumor growth. Based on its 1,3-disubstituted urea structure,<unk>  is also a potent soluble epoxide hydrolase inhibitor and this activity likely reduces the severity of its adverse effects.
Sorafenib
Encorafenib
Regorafenib
Neratinib
Tucatinib
Capmatinib
Lapatinib
Dasatinib