Structure of hemoglobin the proteins α and β subunits are in red and blue,<unk>  is autosomal recessive disorder, which means both parents are affected and two copies of the gene must be present. A carrier gets a normal gene to produce hemoglobin A, from one parent and the other parent supplies a gene which makes no hemoglobin A.<unk>  is considered rare.<unk>  is caused by deletions of the entire<unk>  and beta genes sequences and only gamma-globin and HbF are formed. Rarely, non-deletional forms have been reported. When two<unk> 0 mutations are inherited, no hemoglobin A2 (alpha2,<unk> 2) are formed. This is innocuous because only 2-3% of normal adult hemoglobin is hemoglobin A2. The individual will have normal hematological parameters (erythrocyte count, total hemoglobin, mean corpuscular volume). The<unk>  demonstrates one mutation is at the +69 position. Relation to beta thalassemia<unk>  can mask the diagnosis of beta thalassemia trait. In beta thalassemia, an increase in hemoglobin A2 results, but the co-existence of a<unk>  mutation will decrease the value of the hemoglobin A2 into the normal range, thereby obscuring the diagnosis of beta thalassemia trait
Delta-beta thalassemia
Sickle cell-beta thalassemia
Beta thalassemia
Alpha-thalassemia
Thalassemia
Hereditary spherocytosis
Diamond–Blackfan anemia
Twin anemia-polycythemia sequence