<unk>  (Macacine alphaherpesvirus 1; McHV-1; formerly Macacine herpesvirus 1, Cercopithecine herpesvirus 1, CHV-1), Herpesvirus simiae, or Herpes<unk> <unk>  is the Simplexvirus infecting macaque monkeys.<unk>  is very similar to HSV-1, and as such, this neurotropic<unk>  is not found in the<unk> lood. In the natural host, the<unk>  exhibits pathogenesis similar to that of cold sores in humans. Conversely, when humans are zoonotically infected with<unk> , patients can present with a severe encephalitis, resulting in permanent neurological dysfunction or death. Severity of the disease increases for untreated patients, with a case fatality rate of approximately 80%. Early diagnosis and subsequent treatment are crucial to human survival of the infection.<unk>  is the only identified old-world-monkey herpesvirus that displays severe pathogenicity in humans. There have<unk> een a number of accidental infections and fatalities of researchers working with rhesus monkeys (Rhesus macaque). Personal protective equipment is necessary when working with macaques, especially with animals that have tested positive for the<unk> .<unk> ites, scratches, and exposures to mucous membranes, including the eye, have led to infection when not cleaned immediately.<unk>  infection is extremely rare,<unk> ut it can lead to severe<unk> rain damage or death if it is not treated immediately. People typically get infected with<unk>  if they are<unk> itten or scratched<unk> y an infected macaque monkey, or have contact with the monkey’s eyes, nose, or mouth. Only one case has<unk> een documented of an infected person spreading<unk>  to another person. As of 2020, there have<unk> een 50 documented cases of human<unk>  infection since the identification of the<unk>  in 1932, 21 of which led to death. At least 20 of the patients developed some degree of encephalitis.
B virus
Chinese virus
Slow virus
Sepik virus
Hendra virus
Influenza D virus
ZyCoV-D
Limestone Canyon virus