<unk>  has different levels of severity. For example, one child with<unk>  may be entirely healthy, with no outward evidence of bone or endocrine problems, enter puberty at close to the normal age, and have no unusual skin pigmentation. Diagnosis may be made only after decades. In other cases, children are diagnosed in early infancy, show obvious bone disease, and obvious increased endocrine secretions from several glands. Skeletal abnormalities All patients with known or suspected<unk>  should undergo a screening evaluation for fibrous dysplasia. Nuclear medicine tests such as technetium-99 scintigraphy are the most sensitive way to detect fibrous dysplasia lesions. CT scan of the skull is the most useful test to evaluate craniofacial fibrous dysplasia. Regular hearing and vision screening is recommended. X-rays are usually sufficient to reveal fibrous dysplasia of the appendicular skeleton, but CT and/or MRI scans can reveal microfractures. Regular screening for scoliosis should also be undertaken. Endocrine abnormalities Patients with known or suspected<unk>  should undergo a screening evaluation for endocrine features. Precocious puberty is typically diagnosed based on clinical presentation. A bone age examination should be performed to evaluation for skeletal maturation. Boys and men should have a screening testicular ultrasound. Hyperthyroidism is diagnosed based on blood tests. A screening thyroid ultrasound exam may be performed. Growth hormone excess is diagnosed using blood tests, such as insulin-like growth factor-1 levels. Monitoring growth rates alone is not sufficient to screen for growth hormone excess, because linear growth in children with<unk>  may be affected by skeletal deformities and other endocrinopathies. Hypophosphatemia is diagnosed by blood phosphorus levels. Cushing<unk>  is very rare, and is typically diagnosed clinically in infants who present with signs of severe illness.
McCune–Albright syndrome
Lightwood–Albright syndrome
Alström syndrome
Young–Madders syndrome
Multiple endocrine neoplasia type 1
Wilson–Turner syndrome
Multiple endocrine neoplasia type 2
Wolcott–Rallison syndrome