A micrograph showing cells with marked nuclear shape and size variation, a component of nuclear<unk> <unk> is a term used in histology and cytopathology to describe variability in the size, shape and staining of cells and/or their nuclei. Several key determinants of cell and nuclear size, like ploidy and the regulation of cellular metabolism, are commonly disrupted in tumors. Therefore, cellular and nuclear<unk> is one of the earliest hallmarks of cancer progression and a feature characteristic of malignant neoplasms and dysplasia. Certain benign cell types may also exhibit<unk>  e.g. neuroendocrine cells, Arias-Stella reaction. A rare type of rhabdomyosarcoma that is found in adults is known as pleomorphic rhabdomyosarcoma. Despite the prevalence of<unk> in human pathology, its role in disease progression is unclear. In epithelial tissue,<unk> in cellular size can induce packing defects and disperse aberrant cells. But the consequence of atypical cell and nuclear morphology in other tissues is unknown.
Pleomorphism 
Nuclear atypia
Zoobiquity
Tumor budding
Hyperplasia
Dysplasia
Lobulation
Hyperkeratinization