After oral administration of<unk>  on an empty stomach, it takes 2 hours for serum concentration levels to peak, significantly longer than other benzodiazepine hypnotics. This delay brings into question the benefit of<unk>  for the treatment of insomnia when compared to other hypnotics (particularly when the major complaint is difficulty falling asleep instead of difficulty maintaining sleep for the entire night), although some studies show that<unk>  may induce sleep within half an hour, indicating rapid penetration into the brain. The peak plasma delay of<unk> , therefore, may not be relevant to<unk> 's efficacy as a hypnotic. If taken after a meal it can take even longer for<unk>  plasma levels to peak and peak levels may be lower than normal.<unk>  significantly alters electrical activity in the brain as measured by EEG, with these changes becoming more pronounced as the dose increases. Roughly half of each dose is metabolized in humans to produce an active metabolite, (a piperazine with lesser potency), the other half is excreted unchanged. The half-life of the active metabolite is about the same as the parent compound<unk> .
Loprazolam
Alprazolam
Clotiazepam
Clonazepam
Phenazepam
Medazepam
Diclazepam
Delorazepam