<unk>  <unk> , also known as<unk> <unk> -monooxygenase, is an enzyme () that in humans is encoded by the<unk>  gene.<unk>  catalyzes the conversion of<unk>  to norepinephrine.<unk>  is converted to norepinephrine by the enzyme<unk>  β-hydroxylase. Ascorbic acid serves as a cofactor. The three substrates of the enzyme are<unk> , vitamin C (ascorbate), and O2. The products are norepinephrine, dehydroascorbate, and H2O.<unk>  is a 290 kDa copper-containing oxygenase consisting of four identical subunits, and its activity requires ascorbate as a cofactor. It is the only enzyme involved in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine the only known transmitter synthesized inside vesicles. It is expressed in noradrenergic neurons of the central nervous system (i.e. locus coeruleus) and peripheral nervous systems (i.e. sympathetic ganglia), as well as in chromaffin cells of the adrenal medulla.
Dopamine beta-hydroxylase
Tyrosine hydroxylase
Catechol-O-methyltransferase
Aromatic L-amino acid decarboxylase
Phenylalanine hydroxylase
Monoamine oxidase B
Monoamine oxidase
Monoamine oxidase A