<unk>  <unk>  is a simple aromatic hydrocarbon that possesses weak estrogenic activity. Its estrogenic effects were discovered in 1937.<unk>  was derived from structural modification of the more potent estrogen diethylstilbestrol, which is a member of the stilbestrol group of nonsteroidal estrogens.<unk>  is the parent compound of a group of nonsteroidal estrogen receptor ligands. It includes the estrogens chlorotrianisene, desmethylchlorotrianisene, estrobin (DBE), M2613, triphenylbromoethylene, triphenylchloroethylene, triphenyliodoethylene, triphenylmethylethylene; the selective estrogen receptor modulators (SERMs) afimoxifene, brilanestrant, broparestrol, clomifene, clomifenoxide, droloxifene, endoxifen, etacstil, fispemifene, idoxifene, miproxifene, miproxifene phosphate, nafoxidine, ospemifene, panomifene, and toremifene. The antiestrogen ethamoxytriphetol (MER-25) is also closely related, but is technically not a derivative of<unk>  and is instead a triphenylethanol derivative. The tamoxifen metabolite and aromatase inhibitor norendoxifen is also a<unk>  derivative. In addition to their estrogenic activity, various<unk>  derivatives like tamoxifen and clomifene have been found to act as protein kinase C inhibitors. The affinity of<unk>  for the rat estrogen receptor is about 0.002% relative to estradiol. For comparison, the relative binding affinities of derivatives of<unk>  were 1.6% for tamoxifen, 175% for afimoxifene (4-hydroxytamoxifen), 15% for droloxifene, 1.4% for toremifene (4-chlorotamoxifen), 0.72% for clomifene, and 0.72% for nafoxidine.
Triphenylethylene
Desmethylchlorotrianisene
Triphenylchloroethylene
Phenylsilatrane
Triphenylbromoethylene
Vinyl chloride
Benzene
Coal tar