Since gestational<unk>  (which arises from a hydatidiform mole) contains paternal DNA (and thus paternal antigens), it is exquisitely sensitive to chemotherapy. The cure rates, even for metastatic gestational<unk> , more than 90% when using chemotherapy for invasive mole and<unk> . As of 2019, treatment with either single-agent methotrexate or actinomycin-D is recommended for low-risk disease, while intense combination regimens including EMACO (etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine (Oncovin) are recommended for intermediate or high-risk disease. Hysterectomy (surgical removal of the uterus) can also be offered to patients > 40 years of age or those for whom sterilisation is not an obstacle. It may be required for those with severe infection and uncontrolled bleeding.<unk>  arising in the testicle is rare, malignant and highly resistant to chemotherapy. The same is true of<unk>  arising in the ovary. Testicular<unk>  has the worst prognosis of all germ-cell cancers. File:Diagram showing stage 1<unk>  CRUK 190.Stage I<unk>  File:Diagram showing stage 2<unk>  CRUK 207.Stage 2<unk>  File:Diagram showing stage 3<unk>  CRUK 220.Stage 3<unk>  File:Diagram showing stage 4<unk>  CRUK 229.Stage 4<unk>
Choriocarcinoma
Embryoma
Embryonal carcinoma
Seminoma
Teratoma
Endometrioid tumor
Leiomyosarcoma
Adenomyoma