An elevation in serum bilirubin level of more than 2 times ULN with associated transaminase rise is an ominous sign. This indicates severe<unk>  and is likely to lead to mortality in 10% to 15% of patients, especially if the offending drug is not stopped (Hy's Law). This is because it requires significant damage to the liver to impair bilirubin excretion, hence minor impairment (in the absence of biliary obstruction or Gilbert syndrome) would not lead to jaundice. Other poor predictors of outcome are old age, female sex, high AST.
Hepatotoxicity
Cardiotoxicity
Phototoxicity
Lipotoxicity
Nephrotoxicity
Neurotoxicity
Pulmonary toxicity
Bone marrow suppression