The antiparasitic drug ivermectin (shown here in royal blue) works by binding to glutamate-gated<unk><unk>  receptors, a type of<unk><unk>  found only in protostomes. It “locks” the receptor in an activated (open) conformation, allowing unrestricted passage of<unk>  (Cl−) ions into the cell, ultimately killing the parasite. (Top view shows the open<unk> , with a central pore through which Cl− is transported; side view shows drug binding. From .) A<unk>  is a type of drug which facilitates ion transmission through<unk><unk> s. An example is 1,10-phenanthroline, which activates Cystic fibrosis transmembrane conductance regulator (CFTR)<unk><unk> s. GABA-A receptor agonists (e.g. lorazepam) may also be considered<unk> s
Chloride channel opener
Channel opener
Channel blocker
Channel modulator
Norepinephrine–dopamine disinhibitor
Beta-adrenergic agonist
Adrenergic release inhibitor
Alpha-adrenergic agonist