The most common side effects of<unk>  treatment are gastrointestinal symptoms including soft stools and diarrhea. These are generally mild to moderate and occur more frequently in the first 2 weeks, and lessen with continued treatment. Based on review by European Medicines Agency (EMA),<unk> -containing medicines use is restricted due to severe diarrhoea and liver disorders in patients. An uncommon side effect is hepatic adverse events (most frequently reported as liver function test abnormalities). These have been described as mild/moderate cases of elevated liver enzymes in the blood. Mild skin reactions (rash, pruritus and eczema) have also been reported with<unk>  treatment. Discoloration of urine (yellow or pink) is another side effect of<unk> . This effect is due to the elimination of rhein metabolites via the urine and no clinical significance has been found; it may also be dependent on general fluid intake.
Diacerein
Beta-Zearalenol
Simmondsin
Alpha-Zearalenol
Ascaricide
Psymberin
Trichothecene
Atractyloside