<unk>  does not cure HIV/AIDS, but it can extend the length of a person's life for several years by slowing the progression of the disease. The type that is widely used and created by Merck is<unk>  sulfate. The pills are created from sulfate salts and are sold in dosages of 100, 200, 333, and 400 mg of<unk> . It is normally used as one of the three drugs in a triple-combination therapy for the HIV virus. Commercially available capsules should be stored at 15 - 30 °C. It should be kept in a tight container so that it is kept away from moisture. Therefore, it is advised that users should keep the pills in the manufacturer-provided bottle and do not remove the desiccant. HIV-1 protease in complex with<unk> . PDB entry<unk>  wears off quickly after dosing. Unboosted<unk>  requires a very precise dosing of 400 mg every eight hours to thwart HIV from forming drug-resistant mutations, including resistances to other protease inhibitors. Boosted<unk>  requires two 400-mg<unk>  capsules with 1 to 2 100-mg ritonavir capsules twice a day. In both cases, the drugs must be taken with plenty of water one or two hours after a meal. It is recommended that users drink at least 1.5 liters a day when intaking the drug. Drug users must significantly increase their water intake due to<unk> 's low solubility that can cause it to crystallize. There are restrictions on what sorts of food may be eaten concurrently with the unboosted<unk>  treatment. Furthermore, it is no longer recommended to use in the United States for initial treatments due to pill burden and risk of kidney stones. Viral resistance Many people were skeptical of being too hopeful with<unk>  due to previous events that occurred with AZT. Viral resistance to the drug leads to the drug becoming useless since the virus evolves to have cells that are able to resist the protease inhibitor. In order to avoid this as much as possible, it is important for users to consistently take the exact amount of the drug at the allocated times. This fear of viral resistance caused a lot of users to be wary of the drug.
Indinavir
Saquinavir
Fosamprenavir
Entecavir
Coronavir
Abacavir
Telaprevir
Fostemsavir