The atypical features seen in cells displaying<unk> sis result from the action of the E5 and E6 oncoproteins produced by HPV. These proteins break down keratin in HPV-infected cells, resulting in the perinuclear halo and nuclear enlargement typical of<unk> s. The E6 oncoprotein, along with E7, is also responsible for the dysregulation of the cell cycle that results in squamous cell dysplasia. The E6 and E7 oncoproteins do this by binding and inhibiting the tumor suppressor genes p53 and RB, respectively. This promotes progression of cells through the cell cycle without appropriate repair of DNA damage, resulting in dysplasia. Due to the ability of HPV to cause cellular dysplasia,<unk> s are found in a number of potentially precancerous lesions.
Koilocyte
Echinocyte
Podocyte
Respirocyte
Prolymphocyte
Centrocyte
Nurse cell
Lymphoblast