Prevention includes gamma irradiation of the lymphocyte-containing blood components such as red blood cells, platelets and granulocytes. Irradiated blood components should be issued in the following situations: :* Intrauterine transfusions :* Prematurity, low birthweight, or erythroblastosis fetalis in newborns :* Congenital immunodeficiencies :* Certain hematologic malignancies (e.g. Hodgkin lymphoma) :* Patients undergoing hematopoietic stem cell transplantation :* Components that are HLA matched, or directed donations from a family member :* Patients receiving fludarabine therapy :* Patients receiving granulocyte transfusions
Transfusion-associated graft-versus-host disease
Transfusion-related acute lung injury
Transfusion associated circulatory overload
Transfusion-related immunomodulation
Transfusion transmitted infection
Post-transplant lymphoproliferative disorder
Immune reconstitution inflammatory syndrome
Overwhelming post-splenectomy infection