When mixed with insulin,<unk> s slow down the onset and increase the duration of insulin action (see NPH insulin).<unk>  is used in cardiac surgery, vascular surgery, and interventional radiology procedures to neutralize the anti-clotting effects of heparin. Adverse effects include increased pulmonary artery pressure and decrease peripheral blood pressure, myocardial oxygen consumption, cardiac output, and heart rate.<unk>  sulfate is an antidote for heparin overdose, but severe allergy may occur. A chain shortened version of<unk>  also acts as a potent heparin antagonist, but with markedly reduced antigenicity. It was initially produced as a mixture made by thermolysin digestion of<unk> , but the actual effective peptide portion VSRRRRRRGGRRRR has since been isolated. An analogue of this peptide has also been produced. In gene therapy,<unk>  sulfate's ability to condense plasmid DNA along with its approval by the U.S. Food and Drug Administration (FDA) have made it an appealing candidate to increase transduction rates by both viral and nonviral (e.g. utilizing cationic liposomes) mediated delivery mechanisms.<unk>  may be used as a drug to prevent obesity.<unk>  has been shown to deter increases in body weight and low-density lipoprotein in high-fat diet rats. This effect occurs through the inhibition of lipase activity, an enzyme responsible for triacylglycerol digestion and absorption, resulting in a decrease in the absorption of dietary fat. No liver damage was found when the rats were treated with<unk> . However, emulsification of long-chain fatty acids for digestion and absorption in the small intestine is less constant in humans than rats, which will vary the effectiveness of<unk>  as a drug. Furthermore, human peptidases may degrade<unk>  at different rates, thus further tests are required to determine<unk> 's ability to prevent obesity in humans.
Protamine
Platelet-rich plasma
Fresh frozen plasma
Aminocaproic acid
Pentoxyverine
Cryoprecipitate
Plasminogen 
Prothrombin complex concentrate