Langendorff technique. Curve A - contractile function of the heart is greatly depressed after<unk> -reperfusion. Curve B - a set of short<unk>  episodes <unk>  preconditioning) before prolonged<unk>  provides functional recovery of contractile activity of the heart at reperfusion.<unk>  results in<unk> ssue damage in a process known as<unk>  cascade. The damage is the result of the build-up of metabolic waste products, inability to maintain cell membranes, mitochondrial damage, and eventual leakage of autolyzing proteolytic enzymes into the cell and surrounding<unk> ssues. Restoration of blood supply to<unk> <unk> ssues can cause additional damage known as reperfusion injury that can be more damaging than the initial<unk> . Reintroduction of blood flow brings oxygen back to the<unk> ssues, causing a greater production of free radicals and reactive oxygen species that damage cells. It also brings more calcium ions to the<unk> ssues causing further calcium overloading and can result in potentially fatal cardiac arrhythmias and also accelerates cellular self-destruction. The restored blood flow also exaggerates the inflammation response of damaged<unk> ssues, causing white blood cells to destroy damaged cells that may otherwise still be viable.
Ischemia
Infarction
Venous stasis
Heat edema
Angiopathy
Contracture
Reperfusion injury
Scar