Distribution of PiZZ in Europe People of Northern European and Iberian ancestry are at the highest risk for<unk> . Four percent of them carry the PiZ allele; between<unk>  in 625 and<unk>  in 2000 are homozygous. Another study detected a frequency of<unk>  in<unk> 550 individuals. The highest prevalence of the PiZZ variant was recorded in the northern and western European countries with mean gene frequency of 0.0140. Worldwide, an estimated<unk> .1 million people have<unk><unk>  and roughly<unk> 16 million are carriers of mutations.<unk>  is one of the most common genetic diseases worldwide and the second most common metabolic disease affecting the liver.
Alpha-1 antitrypsin deficiency
Asthma
CHILD syndrome
Reactive airway disease
Mineral dust airway disease
Cystic fibrosis
Yokkaichi asthma
Upper airway resistance syndrome