The disorders associated with<unk>  are generally inherited, although certain liver diseases can also affect fibrinogen levels and function (e.g. cirrhosis). Afibrinogenemia is a recessive inherited disorder, where both parents must be carriers. Hypofibrinogenemia and dysfibrinogenemia can be dominant (i.e. only one parent needs to be a carrier) or recessive. The origin of the disorders is traced back to three possible genes: FGA, FGB, or FGG. Because all three are involved in forming the hexameric glycoprotein fibrinogen, mutations in any one of the three genes can cause the<unk> .
Factor I deficiency
Factor XIII deficiency
Factor X deficiency
Factor VII deficiency
Factor XII deficiency
COAT platelet defect
Protein S deficiency
Protein C deficiency