Pharmacodynamics<unk>  is an ergot alkaloid derivative that acts as a potent and selective α1A-adrenergic receptor antagonist. The IC50 of<unk>  in vitro has been reported to be 0.2 nM. The primary action of<unk>  is to increase arterial blood flow by vasodilation. Furthermore, it is known that<unk>  inhibits platelet aggregation. Studies have shown that<unk>  also increases nerve growth factor in the aged brain. In addition to the α1A-adrenergic receptor,<unk>  is an antagonist of the serotonin 5-HT1A receptor (IC50 = 6 nM) and shows moderate affinity for serotonin 5-HT2 and α2-adrenergic receptors and low affinity for the dopamine D1 and D2 and muscarinic acetylcholine M1 and M2 receptors. The major metabolites of<unk> , MMDL and MDL, show low or no affinity for adrenergic, serotonin, dopamine, or acetylcholine receptors.
Nicergoline
Metergoline
Avacopan
Drospirenone
Nitrazepam
Beclamide
Tolperisone
Clonidine