Complications Protein C is vitamin K-dependent. Patients with<unk>  are at an increased risk of developing skin necrosis while on warfarin. Protein C has a short half life (8 hour) compared with other vitamin K-dependent factors and therefore is rapidly depleted with warfarin initiation, resulting in a transient hypercoagulable state.
Protein C deficiency
Activated protein C resistance
Factor VII deficiency
Protein S deficiency
COAT platelet defect
Factor XIII deficiency
Factor XII deficiency
Antithrombin III deficiency