No specific therapy for LENAS is currently known or proven to cure this disease, but management of it should be immediately initiated following diagnosis. While more research should be taken, some suggest that hematopoietic stem cell transplantation may show a therapeutic role for this disease. Management Management is important in support of this disease and includes attention to general care and nutrition requirements and other possible drug therapies that may help or slow the progression of the disease. L-dopa or other dopaminergic therapies have not yet been beneficial in individuals with this disease but was noted that it may be worth trying as it does not show negative effects. Antipsychotics are in general not recommended due to extrapyramidal side effects. However, they may be used in aggressive individuals. Anti-seizure medications should be initiated in individuals who are having seizure activity along with having this disease as it is reported to be beneficial. Surveillance Periodic clinical evaluation and surveillance to monitor the progression of the disease is appropriate to determine if changes need to be made: * Changes in mobility, communication, and behavior, which could indicate the need to alter care and support systems (for example, moving to a nursing facility or getting personal care, access to wheelchair or walker, etc). * Onset of seizure activity may cue in the need for anti-seizure therapy * Contractures, which could indicate the need to change medical management and physical therapy * More severe behavioral changes that appeared to have worsened. This could include inappropriate emotions and actions, problems following directions, memory loss, and incontinence all which indicate curtailing of independence * Difficulties in swallowing or weight loss, which trigger physicians consideration for gastrostomy * Need for physical therapy to minimize contractures and maintain locomotion
Leukoencephalopathy with neuroaxonal spheroids
Leukoencephalopathy with vanishing white matter
Megalencephalic leukoencephalopathy with subcortical cysts
Neurodegeneration with brain iron accumulation
Camel spongiform encephalopathy
Neurofibrillary tangle
Limbic-predominant age-related TDP-43 encephalopathy
Variably protease-sensitive prionopathy