Symptoms of<unk>  <unk>  are often triggered or made worse by<unk>  temperatures or a viral infection. Therefore, symptoms generally are worse during winter months. Symptoms may arise suddenly leading to abrupt onset of severe anemia and hemoglobinuria or develop more gradually and insidiously in the background without patient's consciousness and precaution. Most people with<unk>  have symptoms of hemolytic anemia (destruction of red blood cells, causing low levels of red blood cells). However, the number of symptoms and severity of symptoms may depend on how severe the anemia is. Signs and symptoms of hemolytic anemia may include: * Tiredness (fatigue) * Dizziness * Headaches *<unk>  hands and feet * Pale skin * Dark urine * Jaundice * Chest pain * Pain in the back or legs * Vomiting or diarrhea * Heart problems such as an irregular heartbeat (arrhythmia), a heart murmur, an enlarged heart, or heart failure. These may occur because the heart has to work harder to make sure the body gets enough healthy red blood cells. Many people with<unk>  also experience pain and bluish coloring of the hands and feet (acrocyanosis) or Raynaud's<unk> . These symptoms result from slow or poor circulation and can range from mild to disabling. Other signs and symptoms of<unk>  may include enlargement of the spleen (splenomegaly) and mottled discoloration of the skin (livedo reticularis). In people with secondary<unk>  (associated with another underlying condition), there may be additional signs and symptoms depending on the condition present. For example: Mycoplasma pneumoniae infection (the most common cause of secondary<unk>  may cause respiratory symptoms. Various infections or cancers may cause enlarged or swollen lymph nodes. ;80–99% of people have these symptoms: * Arthralgia * Autoimmunity * Fatigue * Hemolytic anemia * Muscular weakness * Pallor ;5–29% of people have these symptoms: * Abnormal urine color * Back pain * Diarrhea * Headache * Hepatomegaly * Lymphadenopathy * Nausea and vomiting * Splenomegaly
Cold agglutinin disease
Atypical hemolytic uremic syndrome
MERRF syndrome
Serum sickness
Cold autoimmune hemolytic anemia
Michels Caskey syndrome
Hennekam syndrome
Uddanam nephropathy