<unk>  (brand names Tekturna and Rasilez) is the first in a class of drugs called direct renin inhibitors. It is used for essential (primary) hypertension. While used for high blood pressure, other better studied medications are typically recommended due to concerns of higher side effects and less evidence of benefit. In December 2011, Novartis halted a trial of the drug after discovering increased nonfatal stroke, kidney complications, high blood potassium, and low blood pressure in people with diabetes and kidney problems. As a result, in 2012: * A new contraindication was added to the product label concerning the use of<unk>  with angiotensin receptor blockers (ARBs) or angiotensin-converting enzyme inhibitors (ACEIs) in patients with diabetes because of the risk of kidney impairment, low blood pressure, and high levels of potassium in the blood. * A warning to avoid use of<unk>  with ARBs or ACEIs was also added for patients with moderate to severe kidney impairment (i.e., where glomerular filtration rate is less than 60 ml/min). * Novartis decided to stop marketing Valturna<unk> /valsartan).<unk>  was co-developed by the Swiss pharmaceutical companies Novartis and Speedel.
Aliskiren
Telmisartan
Olmesartan
Cyclothiazide
Amiloride
Chlorothiazide
Losartan
Azilsartan