When administered on an empty stomach, the median Tmax of<unk>  is 1.5 hours. The AUC is estimated to be 7693 ng/mL and the Cmax is estimated at 955 ng/mL. The volume of distribution is approximately 2,154 L and distributes within the red blood cells. The distribution between the plasma and whole blood is affected by temperature and concentration. The protein binding of<unk>  is 97%. The average terminal half-life of<unk>  is 63.6 L/h. The drug is mainly metabolized by the CYP3A4 hepatic cytochrome enzyme. Pharmacologic activity is mainly attributed to the parent molecule itself, with the major metabolite being 8-fold less potent than the parent drug.
Voclosporin
Dapsone
Ciclosporin
Caspofungin
Cortistatin 
Ketoconazole
Miconazole
Itraconazole