The Netherlands Antilles, where<unk>  is more common than anywhere in the world, located off the coast of Venezuela. Population studies from numerous areas in the world have shown that<unk>  occurs at roughly the same rate in almost all populations: somewhere around 1 in 5000. In some areas, it is much more common; for instance, in the French region of Haut Jura the rate is 1:2351 - twice as common as in other populations. This has been attributed to a founder effect, in which a population descending from a small number of ancestors has a high rate of a particular genetic trait because one of these ancestors harbored this trait. In Haut Jura, this has been shown to be the result of a particular ACVRL1 mutation (named c.1112dupG or c.1112_1113insG). The highest rate of<unk>  is 1:1331, reported in Bonaire and Curaçao, two islands in the Caribbean belonging to the Netherlands Antilles. Most people with<unk>  have a normal lifespan. The skin lesions and nosebleeds tend to develop during childhood. AVMs are probably present from birth, but don't necessarily cause any symptoms. Frequent nosebleeds are the most common symptom and can significantly affect quality of life.
Hereditary hemorrhagic telangiectasia
Pedophilia
Patau syndrome
Ehlers–Danlos syndromes
Haemophilia
Bernard–Soulier syndrome
Ogden syndrome
Panayiotopoulos syndrome