* Clinical course * Respiratory difficulties (like upper airway obstruction. (Note regarding clinical variability: respiratory difficulties might be absent.) * Pneumonia * Failure to thrive * Psychomotor retardation Respiratory complications are often cause of death in early infancy. Differential diagnosis<unk>  is not to be confused with: *<unk>  syndrome (aka periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA syndrome, see also: periodic fever syndrome) * Sotos (like) syndrome (Malan syndrome) * Weaver-Smith syndrome (WSS)
Marshall–Smith syndrome
Smith–Magenis syndrome
Smith Martin Dodd syndrome
Langer–Giedion syndrome
Bardet–Biedl syndrome
Wilson–Turner syndrome
Miller–Dieker syndrome
Rothmund–Thomson syndrome