<unk> has been marketed in intramuscular and vaginal formulations and was used as an<unk> n in the treatment of symptoms of low<unk> n levels such as hot flashes and vaginal atrophy in postmenopausal or ovariectomized women.<unk> has also been used as an antigonadotropin and form of high-dose<unk> n to treat prostate cancer in men as well as a form of high-dose<unk> n to treat breast cancer in women. It has since largely been discontinued and is mostly no longer available, having been superseded by other<unk> ns with better potency and pharmacokinetics (namely oral bioavailability and duration). Regardless of route of administration, if<unk> is taken by a woman with an intact uterus, it should be combined with a progestogen such as progesterone to offset the risk of endometrial hyperplasia and cancer.<unk> has been used by intramuscular injection at a dosage of 0.1 to 2 mg per week, or 0.1 to 0.5 mg given 2 or 3 times per week, for the treatment of menopausal symptoms such as hot flashes and vaginal atrophy, and at a dosage of 0.1 to 1.0 mg weekly in single or divided doses for the treatment of female hypogonadism, surgical castration, and primary ovarian failure. The range of single doses of<unk> by intramuscular injection that are typically used clinically in women is 0.1 to 5 mg. High doses of intramuscular<unk> have been used for prostate cancer in men and for breast cancer in women. Available forms<unk> for intramuscular injection was provided as 1, 2, 2.5, 3, 4, and 5 mg/mL aqueous suspensions and/or oil solutions. It has also been available in the form of vaginal creams (1 mg/g (0.1%)) and suppositories (0.2 mg, 0.25 mg) as well as subcutaneous pellet implants and oral tablets (1.25 mg). A combined oral tablet formulation containing estradiol (0.3 mg, 0.6 mg),<unk> (0.7 mg, 1.4 mg), and estriol (0.135 mg, 0.27 mg) has been marketed under the brand name Hormonin as well. In addition, a combined injectable preparation containing<unk> (1 mg) and progesterone (10 mg) is available in the form of ampoules under the brand name Synergon. Although<unk> by intramuscular injection was originally formulated as an oil solution, it was soon replaced by formulations of<unk> as an aqueous suspension due to a longer duration of action of these formulations.
Estrone 
Methyltestosterone
Allyltestosterone
Androgen
Estradiol
Estradiol 
Dihydrotestosterone
2-Hydroxyestradiol