<unk>  primarily affects the circulatory system, specifically the platelets in the blood. Platelets are cell fragments in the blood that aid in clotting. Platelets are produced in the bone marrow. Normal platelet counts range from 150,000 to 450,000 platelets per µL of blood. Individuals with<unk> LT usually have drastically reduced platelet counts, typically less than 70,000 platelets per µL of blood. Not only are there fewer platelets circulating, but individuals with<unk> LT also have smaller platelets. Fewer and smaller platelets causes the efficacy of the clotting mechanism in the body to be seriously compromised, which can lead to bruising and bleeding.<unk>  is caused by a mutation of the WAS gene. This mutation causes the decreased, absent, or altered Wiskott–Aldrich syndrome protein (WASp). Normal WASp is involved in relaying signals from the cell membrane to the actin cytoskeleton. If WASp is decreased, absent, or altered, then the hematopoietic cells it is found in will show signaling and cytoskeleton abnormalities. This form of thrombocytopenia is inherited on<unk>  chromosome, thus individuals with this disorder are typically males. In regards to the sex chromosomes, males have one<unk>  chromosome and one Y chromosome while females have two<unk>  chromosomes. Because males only have one<unk>  chromosome, if they receive an<unk>  chromosome with a WAS gene mutation from their mother, then they will show phenotype of the condition. Females can be carriers for this disorder, which means that they have one normal<unk>  chromosome and one<unk>  chromosome with the WAS gene mutation. Females that are carriers do not show any signs or symptoms of<unk> . Males with<unk>  are also susceptible to severe infections, bleeding, autoimmune diseases and malignancies.
X linked thrombocytopenia
MBL deficiency
Congenital amegakaryocytic thrombocytopenia
Leukocyte adhesion deficiency-1
Harris platelet syndrome
COAT platelet defect
Gray platelet syndrome
Rh deficiency syndrome