Pharmacokinetics Pharmacokinetics refers to the study of absorption, distribution, metabolism and elimination of drugs in human body. + NSAIDs Glucocortiocids Absorption A majority of NSAIDs have good oral absorption. (Degree of absorption ranged from 55%- 100%) Most glucocorticoids have good oral absorption (Degree of absorption ranged from 60% to 100%) Distribution NSAIDs are highly bound to plasma proteins, making them more difficult to distribute to the site of actions. Glucocorticoids are distributed by binding with protein, mainly glycoprotein, transcortin and albumin. Metabolism The majority of NSAIDs undergo glucoronidation during phase II metabolism in the liver Glucocorticoids undergo phase I and phase II metabolism in the liver. The common phase I metabolisms that glucocorticoids undergo are oxidation and hydrogenation. Glucocorticoids undergo glucoronidation and sulphation during phase II metabolism in the liver Elimination Renal Excretion Renal Excretion Pharmacodynamics Pharmacodynamics refers to the study of how the drugs exert their actions in human body. NSAIDs NSAIDs inhibits the synthesis of<unk>  by inhibiting cyclooxygenase (COX-1 and COX-2). NSAIDs with higher selectivity on COX-2 such as indomethacin, zomeoirac and diclofenac have potent anti- inflammatory activity and fewer side effects on stomach and kidney. Glucocorticoids Phospholipase A2 is an enzyme to catalyze the release of arachidonic acid in our body. After arachidonic acid is released, it can be converted to<unk> s by cyclooxygenase. Glucocorticoids work by inhibiting phospholipase A2, hence indirectly inhibiting<unk>  synthesis.
Prostaglandin inhibitors
Lipase inhibitors
COX-2 inhibitor
Nonsteroidal anti-inflammatory drug
Antiandrogen
Proton-pump inhibitor
Antiplatelet drug
Thyroid blocker