<unk>  is a set of symptoms (a syndrome) arising from the sudden withdrawal or reduction of<unk> s where previous usage has been heavy and prolonged. Signs and symptoms of withdrawal can include drug craving, anxiety, restless legs, nausea, vomiting, diarrhea, sweating, and an increased heart rate.<unk>  use triggers a rapid adaptation in cellular signalling pathways that means, when rapidly withdrawn, there can be adverse physiological effects. All<unk> s, both recreational drugs and medications, when reduced or stopped, can lead to<unk>  symptoms. When withdrawal symptoms are due to recreational<unk>  use, the term<unk>  use disorder is used, whereas when due to prescribed medications, the term prescription<unk>  use disorder is used.<unk>  can be helped by the use of<unk>  replacement therapy, and symptoms may be relieved by the use of medications including lofexidine and clonidine.
Opioid withdrawal
Nicotine withdrawal
Drug withdrawal
Benzodiazepine withdrawal syndrome
Benzodiazepine dependence
Antidepressant discontinuation syndrome
Post-acute-withdrawal syndrome
Amphetamine dependence