<unk>  thickens with age, slowing the transport of metabolites. This may lead to the formation of drusen in age-related macular degeneration. There is also a buildup of deposits (Basal Linear Deposits or BLinD and Basal Lamellar Deposits BLamD) on and within the<unk> , primarily consisting of phospholipids. The accumulation of lipids appears to be greater in the central fundus than in the periphery. This build up seems to fragment the<unk>  into a lamellar structure more like puff-pastry than a barrier. Inflammatory and neovascular mediators can then invite choroidal vessels to grow into and beyond the fragmented<unk> . This neovascular<unk>  destroys the architecture of the outer retina and leads to sudden loss of central vision – wet age related macular degeneration. Pseudoxanthoma elasticum, myopia and trauma can also cause defects in<unk>  which may lead to choroidal neovascularization. Alport's Syndrome, a genetic disorder affecting the alpha(IV) collagen chains, can also lead to defects in the<unk><unk>  such as 'dot and fleck' retinopathy. Angioid streaks cause calcification, thickening and breaks in<unk> .
Bruch's membrane
Schneiderian membrane
Reticular membrane
Rosenthal fiber
Dua's layer
Acemetacin
St Peter's Medal
Fibrous cap