Pharmacodynamics<unk>  appears to bind to dopamine D2 receptors with nanomolar affinity (Ki = 28.8 nM), where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/5-HT4 receptor agonist. Mechanism of action The antiemetic action of<unk>  is due to its antagonist activity at D2 receptors in the chemoreceptor trigger zone in the central nervous system — this action prevents nausea and vomiting triggered by most stimuli. At higher doses, 5-HT3 antagonist activity may also contribute to the antiemetic effect. The gastroprokinetic activity of<unk>  is mediated by muscarinic activity, D2 receptor antagonist activity, and 5-HT4 receptor agonist activity. The gastroprokinetic effect itself may also contribute to the antiemetic effect.<unk>  also increases the tone of the lower esophageal sphincter.<unk>  might influence on mood because of its blockade action on 5-HT4 and 5-HT3.
Metoclopramide
Omeprazole
Rabeprazole
Lansoprazole
Esomeprazole
Dexlansoprazole
Pantoprazole
Ranitidine