Estradiol, the active form of EBB. Pharmacodynamics EBB is an estradiol ester, or a prodrug of estradiol. As such, it is an estrogen, or an agonist of the estrogen receptors. EBB is of about 64% higher molecular weight than estradiol due to the presence of its C3 benzoate and C17β<unk>  esters. Because EBB is a prodrug of estradiol, it is considered to be a natural and bioidentical form of estrogen. The estrogenic potency of oral ethinylestradiol is approximately 30-fold higher than that of parenteral EBB. In accordance, 50 μg/day oral ethinylestradiol has been reported to be about 3 times stronger in estrogenic effect than once-a-month injections of 10 mg EBB. Pharmacokinetics A single 10 mg intramuscular injection of EBB has a duration of approximately 3 weeks. Its duration is shorter than that of estradiol enantate. A preliminary study of the duration of EBB relative to other estradiol esters was conducted in 1952.
Estradiol benzoate butyrate
Progestogen ester
Estriol succinate
Estriol tripropionate
Estradiol benzoate/testosterone isobutyrate
Estradiol furoate
Estradiol diundecylenate
Estradiol dienantate