Hodgkin lymphoma A special type of<unk>  (RSC) is the lacunar histiocyte, whose cytoplasm retracts when fixed in formalin, so the nuclei give the appearance of cells that lie with empty spaces (called lacunae) between them. These are characteristic of the nodular sclerosis subtype of Hodgkin lymphoma. Mummified RSCs (compact nucleus, basophilic cytoplasm, no nucleolus) are also associated with classical Hodgkin's lymphoma while popcorn cells (small cell with hyper-lobulated nucleus and small nucleoli) are lymphohistiocytic (L-H) variant of<unk> s and are associated with nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). RSCs and one<unk>  line (L1236 cells) but not other<unk>  lines express very high levels of ALOX15 (i.e., 15-lipoxygenase-1) or possibly ALOX15B (i.e. 15-lipoxygenase-2), enzymes that metabolize arachidonic acid and various other polyunsaturated fatty acids to a wide array of bioactive products including in particular those of the 15-Hydroperoxyeicosatetraenoic acid family of arachidonic acid metabolites. This is unusual in that lymphocytes typically express little or no ALOX15. It is suggested that ALOX15 and/or ALOX15B, perhaps operating through one of its arachidonic acid-derived products, the eoxins, contributes to the development and/or morphology of Hodgkin lymphoma.
Reed–Sternberg cell
Touton giant cell
Small cleaved cells
Langhans giant cell
Howell–Jolly body
Lutzner cells
Hematoxylin body
Acanthocyte