<unk>  (abbreviated<unk>  or<unk>  is a protein involved in the breakdown of blood clots. It is a serine protease () found on endothelial cells, the cells that line the blood vessels. As an enzyme, it catalyzes the conversion of<unk>  to plasmin, the major enzyme responsible for clot breakdown. Human<unk>  has a molecular weight of ~70 kDa in the single-chain form.<unk>  can be manufactured using recombinant biotechnology techniques;<unk>  produced by such means are referred to as recombinant<unk>  (rtPA). Specific rtPAs include<unk> , reteplase, and tenecteplase. They are used in clinical medicine to treat embolic or thrombotic stroke. The use of this protein is contraindicated in hemorrhagic stroke and head trauma. The antidote for<unk>  in case of toxicity is aminocaproic acid.
Tissue plasminogen activator
Argatroban
Lusutrombopag
Anistreplase
Bivalirudin
Heparin
Prothrombin complex concentrate
Palladin