Deficiency DHEA and DHEA sulfate (DHEA-S) are produced by the adrenal glands. In people with adrenal insufficiency such as in Addison's disease, there may be deficiency of DHEA and DHEA-S. In addition, levels of these steroids decrease throughout life and are 70 to 80% lower in the elderly relative to levels in young adults.<unk>  can be used to increase DHEA and DHEA-S levels in adrenal insufficiency and older age. Although there is deficiency of these steroids in such individuals, clinical benefits of supplementation, if any, are uncertain, and there is insufficient evidence at present to support the use of<unk>  for such purposes. Menopause<unk>  is sometimes used as an androgen in menopausal hormone therapy. In addition to<unk>  itself, a long-lasting ester prodrug of<unk> ,<unk>  enanthate, is used in combination with estradiol valerate for the treatment of menopausal symptoms under the brand name Gynodian Depot. Vaginal atrophy<unk> , under the brand name Intrarosa, is approved in the United States in a vaginal insert formulation for the treatment of atrophic vaginitis. The mechanism of action of<unk>  for this indication is unknown, though it may involve local metabolism of<unk>  into androgens and estrogens. Sexual desire<unk>  has been used orally at a dosage of 10 mg/day to increase sexual desire in women. Childbirth As the sodium salt of<unk>  sulfate (brand names Astenile, Mylis, Teloin), an ester prodrug of<unk> ,<unk>  is used in Japan as an injection for the treatment of insufficient cervical ripening and cervical dilation during childbirth. Available forms<unk>  was previously marketed as a pharmaceutical medication under the brand name Diandrone in the form of a 10 mg oral tablet in the United Kingdom.
Prasterone
Chlordecone
Enoximone
Dipipanone
Azacyclonol
Methasterone
Iomeprol
Crotamiton