Breast cancer is classified into three major subtypes for the purpose of predicting response to treatment. These are determined by the presence or absence of receptors on the cells of the tumor. The three major subgroups are: * Luminal-type, which are tumors positive for hormone receptors (estrogen or progesterone receptor). This subtype suggests a response to endocrine therapy. * HER2-type, which are positive for over-expression of the HER2 receptor. ER and PR can be positive or negative. This subtype receives targeted therapy. * Basal-type, or Triple Negative (TN), which are negative for all three major receptor types Additional classification schema are used for prognosis and include histopathology, grade, stage, and genomic profiling.
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