<unk>  <unk>  is a term used in clinical psychiatry to describe a condition that affects people with major depressive disorder (MDD) who do not respond adequately to a course of appropriate antidepressant medication within a certain time. Typical definitions of<unk>  vary, and they do not include a<unk> e to psychological therapies. Inadequate response has traditionally been defined as no clinical response whatsoever (e.g. no improvement in depressive symptoms). However, many clinicians consider a response inadequate if the person does not achieve full remission of symptoms. People with<unk>  who do not adequately respond to antidepressant<unk>  are sometimes referred to as pseudoresistant. Some factors that contribute to inadequate<unk>  are: early discontinuation of<unk> , insufficient dosage of medication, patient noncompliance, misdiagnosis, and concurrent psychiatric disorders. Cases of<unk>  may also be referred to by which medications people with<unk>  are<unk>  to (e.g.: SSRI-resistant). In<unk>  adding further<unk> s such as psychotherapy, lithium, or aripiprazole is weakly supported as of 2019.
Treatment-resistant depression
Long-term depression
Recurrent brief depression
Outline of bipolar disorder
Chronic hallucinatory psychosis
Double depression
Mass psychogenic illness
Late life depression