Clinical work up for patients with suspected<unk>  includes the taking of a medical history and physical examination looking for additional location with<unk>  deposits, lymphadenopathy, and hepatosplenomegaly. Laboratory testing includes a complete peripheral blood count, bone marrow aspirate, serum and urine protein studies, serum free light chain analysis, and a complete skeletal survey to detect blastic-lytic lesions and osteopenia. Even if patients do not have a monoclonal gammopathy before a diagnosis of<unk> , they are often tested to see if there is an underlying monoclonal gammopathy, due to the link between the disorders. Patients who do not have a monoclonal gammopathy at diagnosis should be regularly tested to detect if one develops. Differential diagnosis Diseases that need to be ruled out to diagnose a patient with<unk>  include rhabdomyoma, granular cell tumor, Langerhans cell histiocytosis, fibrous histiocytoma, xanthogranuloma, Gaucher's disease, malakoplakia, and mycobacterial spindle cell pseudotumor.
Crystal-storing histiocytosis
Sea-blue histiocytosis
X-type histiocytosis
Langerhans cell histiocytosis
Non-Langerhans cell histiocytosis
Non-X histiocytosis
Malignant histiocytosis
Progressive nodular histiocytosis