<unk>  is a rare inherited cancer predisposition associated with pathogenic CDH1 (gene) germline mutations, and without apparent correlation with the<unk>  diffuse gastric cancer syndrome. Research studies identified novel CDH1 germline variants in women with diagnosed<unk>  breast cancer (in invasive and/or in situ histotype) and without any family history of gastric carcinoma. Firstly, in 2018 Giovanni Corso et al. defined this syndrome as a new cancer predisposition and the Authors suggested additional clinical criteria to testing CDH1 in<unk>  breast cancer patients. In 2020, the International Gastric Cancer Linkage Consortium recognized officially that the<unk>  is a novel and independent syndrome. To date, the are reported about 40 families clustering for<unk>  breast cancer and associated with CDH1 germline mutations but without association with diffuse gastric cancer (unpublished data).
Hereditary lobular breast cancer
Paget's disease of the breast
Hormone receptor positive breast tumor
Triple-negative breast cancer
Medullary breast carcinoma
Inflammatory breast cancer
Mucinous carcinoma of the breast
Benign proliferative breast disease