Using gene transfer of SV40 large T-antigen in neuronal precursor cells of rats, a brain tumor model was established. The<unk> s were histologically indistinguishable from the human counterparts and have been used to identify new genes involved in human brain tumor carcinogenesis. The model was used to confirm p53 as one of the genes involved in human medulloblastomas, but since only about 10% of the human tumors showed mutations in that gene, the model can be used to identify the other binding partners of SV40 Large T- antigen, other than p53.
Primitive neuroectodermal tumor
Ameloblastoma
Dysembryoplastic neuroepithelial tumour
Pediatric ependymoma
Neurothekeoma
Sialoblastoma
Melanotic neuroectodermal tumor of infancy
Neuroma