Naming In January<unk> 021, the lineage was first documented in Colombia and was named as lineage B.1.621. On July 1,<unk> 021, Public Health England (PHE) named lineage B.1.621 VUI-21JUL-1. On August 30,<unk> 021, the World Health Organization (WHO) named lineage B.1.621<unk>  variant.<unk> tations The<unk>  genome has a total number of<unk> 1<unk> tations, including 9 amino acid<unk> tations, all of which are in the virus's spike protein code: T95I, Y144S, Y145N, R346K, E484K or the escape<unk> tation, N501Y, D614G, P681H, and D950N. It has an insertion of one amino acid at position 144/145 of the spike protein, giving a total<unk> tation YY144–145TSN. That<unk> tation is conventionally notated as Y144S and Y145N because insertions would break a lot of comparison tools. It also features a frame-shift deletion of four nucleotides in ORF3a that generates a stop codon two amino acids. The<unk> tation is labeled as V256I, N257Q, and P258*. The list of defining<unk> tations are: S: T95I, Y144S, Y145N, R346K, E484K, N501Y, D614G, P681H, and D950N; ORF1a: T1055A, T1538I, T3255I, Q3729R; ORF1b: P314L, P1342S; N: T205I, ORF3a: Q57H, V256I, N257Q, P258*; ORF8: T11K, P38S, S67F.<unk> tations in viruses are not new. All viruses, including SARS-CoV-2, undergo change over time. Most of these changes are inconsequential, but some can alter properties to make these viruses more virulent or escape the treatment or vaccines. On August 31,<unk> 021, the WHO released an update which stated that the "Mu variant has a constellation of<unk> tations that indicate potential properties of immune escape", noting that preliminary studies showed some signs of this but that "this needs to be confirmed by further studies." One such study conducted in a lab in Rome tested the effectiveness of sera collected from recipients of the BioNTech-Pfizer vaccine against the<unk>  variant, and found that "neutralization of SARS-CoV-2 B.1.621 lineage was robust", albeit at a lower level than that observed against the B.1 variant. File:SARS-CoV-2_Mu_variant_mutations.Amino acid<unk> tations of<unk>  plotted on a genome map of SARS-CoV-2 with a focus on the spike. Characteristic<unk> tations of<unk>  Variant Gene Amino acid ORF1a T1055A T1538I T3255I Q3729R ORF1b P314L P1342S S T95I Y144S Y145N R346K E484K N501Y D614G P681H D950N ORF3a Q57H del257/257 ORF8 T11K P38S S67F N T205I
SARS-CoV-2 Mu variant
SARS-CoV-2 Omicron variant
SARS-CoV-2 Delta variant
SARS-CoV-2 Gamma variant
SARS-CoV-2 Alpha variant
SARS-CoV-2 Epsilon variant
SARS-CoV-2 Lambda variant
SARS-CoV-2 Kappa variant