About 80% of those infected with<unk> <unk>  virus <unk> V) show no symptoms and go unreported. About 20% of infected people develop symptoms. These vary in<unk> ity, and begin 3 to 14 days after being bitten. Most people with mild symptoms of<unk> V recover completely, though fatigue and weakness may last for weeks or months. Symptoms may range from mild, such as<unk> , to<unk> e, such as paralysis and meningitis. A<unk> e infection can last weeks and can, rarely, cause permanent brain damage. Death may ensue if the central nervous system is affected. Medical conditions such as cancer and diabetes, and age over 60 years, increase the risk of developing<unk> e symptoms. Headache can be a prominent symptom of<unk> V<unk> , meningitis, encephalitis, meningoencephalitis, and it may or may not be present in poliomyelitis-like syndrome. Thus, headache is not a useful indicator of neuroinvasive disease. *<unk>  <unk> , which occurs in 20 percent of cases, is a febrile syndrome that causes flu-like symptoms. Most characterizations of<unk>  describe it as a mild, acute syndrome lasting 3 to 6 days after symptom onset. Systematic follow-up studies of patients with<unk>  have not been done, so this information is largely anecdotal. Possible symptoms include high<unk> , headache, chills, excessive sweating, weakness, fatigue, swollen lymph nodes, drowsiness, pain in the joints and flu-like symptoms. There may be gastrointestinal symptoms including nausea, vomiting, loss of appetite, and diarrhea.<unk>  than one-third of patients develop a rash. *<unk> <unk>  neuroinvasive disease <unk> ND), which occurs in less than 1 percent of cases, is when the virus infects the central nervous system resulting in meningitis, encephalitis, meningoencephalitis or a poliomyelitis-like syndrome. Many patients with<unk> ND have normal neuroimaging studies, although abnormalities may be present in various cerebral areas including the basal ganglia, thalamus, cerebellum, and brainstem. *<unk> <unk>  virus encephalitis <unk> E) is the most common neuroinvasive manifestation of<unk> ND.<unk> E presents with similar symptoms to other viral encephalitis with<unk> , headaches, and altered mental status. A prominent finding in<unk> E is muscular weakness (30 to 50 percent of patients with encephalitis), often with lower motor neuron symptoms, flaccid paralysis, and hyporeflexia with no sensory abnormalities. *<unk> <unk>  meningitis <unk> M) usually involves<unk> , headache, stiff neck and pleocytosis, an increase of white blood cells in cerebrospinal fluid. Changes in consciousness are not usually seen and are mild when present. *<unk> <unk>  meningoencephalitis is inflammation of both the brain (encephalitis) and meninges (meningitis). *<unk> <unk>  poliomyelitis <unk> P), an acute flaccid paralysis syndrome associated with<unk> V infection, is less common than<unk> M or<unk> E. This syndrome is generally characterized by the acute onset of asymmetric limb weakness or paralysis in the absence of sensory loss. Pain sometimes precedes the paralysis. The paralysis can occur in the absence of<unk> , headache, or other common symptoms associated with<unk> V infection. Involvement of respiratory muscles, leading to acute respiratory failure, sometimes occurs. *<unk> -Nile<unk> sible paralysis, Like<unk> P, the weakness or paralysis is asymmetric. Reported cases have been noted to have an initial preservation of deep tendon reflexes, which is not expected for a pure anterior horn involvement. Disconnect of upper motor neuron influences on the anterior horn cells possibly by myelitis or glutamate excitotoxicity have been suggested as mechanisms. The prognosis for recovery is excellent. * Nonneurologic complications of<unk> V infection that may rarely occur include fulminant hepatitis, pancreatitis, myocarditis, rhabdomyolysis, orchitis, nephritis, optic neuritis and cardiac dysrhythmias and hemorrhagic<unk>  with coagulopathy. Chorioretinitis may also be more common than previously thought. * Skin manifestations, specifically rashes, are common; however, there are few detailed descriptions in case reports, and few images are available. Punctate erythematous, macular, and papular eruptions, most pronounced on the extremities have been observed in<unk> V cases and in some cases histopathologic findings have shown a sparse superficial perivascular lymphocytic infiltrate, a manifestation commonly seen in viral exanthems. A literature review provides support that this punctate rash is a common cutaneous presentation of<unk> V infection.
West Nile fever
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Brain fever
Zika fever
Dengue fever
Malaria
Blackwater fever
Argentine hemorrhagic fever