Like other fluoroquinolones,<unk>  prevents bacterial DNA replication, transcription, repair and recombination through inhibition of bacterial DNA gyrase. Quinolones and fluoroquinolones are bactericidal drugs, eradicating bacteria by interfering with DNA replication. Quinolones are synthetic agents that have a broad spectrum of antimicrobial activity as well as a unique mechanism of action, resulting in inhibition of bacterial DNA gyrase and topoisomerase IV. Quinolones inhibit the bacterial DNA gyrase or the topoisomerase IV enzyme, thereby inhibiting DNA replication and transcription. For many gram-negative bacteria, DNA gyrase is the target, whereas topoisomerase IV is the target for many gram-positive bacteria. It is believed that eukaryotic cells do not contain DNA gyrase or topoisomerase IV.
Prulifloxacin
Telithromycin
Azithromycin
Dirithromycin
Roxithromycin
Moxifloxacin
Gemifloxacin
Merafloxacin