CT-scan of the skull of a patient with coronal synostosis, orbital hypertelorism, and facial asymmetry as part of<unk> . Picture of longitudinal ridging and splitting of the toenails as part of<unk> . Phenotypic expression varies greatly between individuals with<unk> . Some of the more prominent characteristics are: * Craniosynostosis of the coronal suture(s) (fusion of the coronal sutures), * Orbital hypertelorism (increased interocular distance), * Bifid nasal tip, * Dry frizzy curled hair, * Longitudinal ridging and / or splitting of the nails, * Facial Asymmetry. Other characteristics that are less frequently seen are: broad nasal base, low anterior hair line, low set ears, crowding of the teeth, maxillary hypoplasia, rounded and sloping shoulders, pectus excavatum, scoliosis, high arched palate, orbital dystopia, low implant of the breasts with asymmetric nipples and volume, webbed neck, hand or foot abnormalities such as clinodactyly (most common is a curved 5th finger) and cutaneous syndactyly (webbed fingers / toes). Females are more commonly and usually more severely affected than males. Males can however have (some of) the same symptoms as females, but this is not frequently seen. Most males have mild symptoms such as hypertelorism and a broad nasal base with bifid nose, but can also be a carrier of the mutation yet stay clinically unaffected.
Craniofrontonasal dysplasia
Frontonasal dysplasia
Oculodentodigital dysplasia
Cleidocranial dysostosis
Cranio-lenticulo-sutural dysplasia
Cleft Lip and Palate Association
Thanatophoric dysplasia
Sponastrime dysplasia