Serpin peptidase inhibitor, clade A, member<unk>  (SERPINA1) is the gene that encodes the protein<unk> -1<unk> . SERPINA1 has been localized to chromosome<unk> 4q32. Over 75 mutations of the SERPINA1 gene have been identified, many with clinically significant effects. The most common cause of severe<unk> , PiZ, is a single base-pair substitution leading to a glutamic acid to lysine mutation at position 342 (dbSNP: rs28929474), while PiS is caused by a glutamic acid to valine mutation at position 264 (dbSNP: rs17580). Other rarer forms have been described .
Alpha-1 antitrypsin deficiency
Asthma
CHILD syndrome
Reactive airway disease
Mineral dust airway disease
Cystic fibrosis
Yokkaichi asthma
Upper airway resistance syndrome