<unk> s <unk> s) are chromosomal segments with various lengths and uniform<unk>  intensity after G banding. This type of aberration is also known as Copy Number Gains or Amplification. An<unk>  is one type of change in a chromosome's structure which is frequently observed in the nucleus of human cancer cells. In the<unk>  of a chromosome where an<unk>  occurs, a segment of the chromosome, which presumably contains a gene or genes that give selective advantage to the progression of the cancer, is amplified or duplicated many times. As a result of the duplication this chromosomal segment is greatly lengthened and expanded such that when it is stained with a fluorescent probe specific to the<unk>  (Fluorescent in situ hybridization), rather than causing a focal fluorescent signal as in a normal chromosome, the probe "paints" a broad fluorescent signal over the whole of the amplified<unk> . It is because of the appearance of this broadly<unk><unk>  that this chromosomal abnormality was named a<unk> . The<unk>  was first observed in chromosome 2 by June Biedler and Barbara Spengler in cells that had been made resistant to methotrexate. The<unk>  was found to due to the amplification of the DHFR gene.
Homogeneously staining region
Nuclear sclerosis
Zoobiquity
Salt-and-pepper chromatin
Contour threads
Nuclear atypia
Nuclear moulding
Storiform pattern