Schematic structure of an antibody Due to the rarity of the disorder, the mechanism behind the disorder is unclear, but suggested mechanisms include changes in the structure of the immunoglobulins due to the underlying malignancy (monoclonal gammopathies result in the production of aberrant immunoglobulins) or due to unusual folding of the aberrant immunoglobulins. Other suggested mechanisms include over-production or reduced removal of immunoglobulins.
Crystal-storing histiocytosis
Sea-blue histiocytosis
X-type histiocytosis
Langerhans cell histiocytosis
Non-Langerhans cell histiocytosis
Non-X histiocytosis
Malignant histiocytosis
Progressive nodular histiocytosis