The specific pathology of<unk>  has not been fully understood yet. It is known, however, that a stimulation of the B cell compartment and by abnormal cell growth of secondary follicles are key factors to the pathology of<unk> . This typically occurs in the cortex without disrupting the lymph node capsule. It has also been described that the condition may stem from primary reactive lymphoid proliferations that may be triggered by an unidentified antigens or some sort of chronic irritation by ultimately causing lymph node enlargement. Lymph node enlargement can occur for many reasons. First of all, the lymph nodes function to act as a filter for the reticuloendothelial system. They contain multi-layered sinus by exposing B and T cell lymphocytes and macrophages and are found within the blood. When the immune system recognizes foreign proteins in order to mount an attack, it requires help from these blood cells. During this reaction the responding cell lines become duplicated in response to a foreign attack, and therefore increase in size. Node size is considered abnormal when it exceeds 1 cm, however this differs from children to adults. Localized or specific adenopathy often occur in clusters or groups of lymph nodes that can migrate to various areas of the body. Lymph nodes are distributed within all areas of the body and when enlarged, reflect the location of lymphatic drainage. The node appearance can range from tender, fixed or mobile and discrete or matted together. It is important to note that reactive lymph nodes are not necessarily a bad thing, in fact they are a good indication that the lymphatic system is working hard. Lymph fluids can build up in lymph nodes as a way to trap harmful bacteria and other harmful pathogens in the body to prevent it from spreading to other areas. Substances that are present within the interstitial fluids such as microorganisms, antigens or even cancer can enter lymphatic vessels by forming the lymphatic fluids. Lymph nodes help filter these fluids by removing material towards the direction of blood circulation. When antigens are presented, the lymphocytes inside of the node trigger a response which can cause proliferation or cell enlargement. This is also referred to as reactive lymphadenopathy.
Follicular hyperplasia
Lymphoid hyperplasia
Perifollicular mucinosis
Microglandular hyperplasia
Hyperkeratinization
Pseudopolyps
Xanthogranulomatous inflammation
Reticular formation