Mechanism of<unk> -switch recombination that allows isotype<unk>  in activated B cells.<unk> , also known as isotype<unk> , isotypic commutation or<unk> -switch recombination (CSR), is a biological mechanism that changes a B cell's production of<unk>  from one type to another, such as from the isotype IgM to the isotype IgG. During this process, the constant-region portion of the antibody heavy chain is changed, but the variable region of the heavy chain stays the same (the terms variable and constant refer to changes or lack thereof between antibodies that target different epitopes). Since the variable region does not change,<unk><unk>  does not affect antigen specificity. Instead, the antibody retains affinity for the same antigens, but can interact with different effector molecules.
Immunoglobulin class switching
Alloantigen recognition
Antibody opsonization
Memory T cell inflation
Fragment antigen-binding
Complement-dependent cytotoxicity
Immune tolerance
Antibody-dependent enhancement