<unk>  is composed of<unk>  matrix supporting a variety of cell types, most of which can be associated with one of the following functions: * formation of extracellular matrix; * operation of the immune system; * vascularisation; An excess of<unk>  (caro luxurians) is informally referred to as "proud flesh". Extracellular matrix Histopathology of<unk>  at 11 days after injury, showing fibroblasts, bleeding and lymphocytes. The extracellular matrix of<unk>  is created and modified by fibroblasts. Initially, it consists of a network of type-III collagen, a weaker form of the structural protein that can be produced rapidly. This is later replaced by the stronger, long-stranded type-I collagen, as evidenced in scar<unk> . Immunity The main immune cells active in the<unk>  are macrophages and neutrophils, although other leukocytes are also present. These work to phagocytize old or damaged<unk> , and protect the healing<unk>  from pathogenic infection. This is necessary both to aid the healing process and to protect against invading pathogens, as the wound often does not have an effective skin barrier to act as a first line of defense. Vascularization It is necessary for a network of blood vessels to be established as soon as possible to provide the growing<unk>  with nutrients, to take away cellular wastes, and transport new leukocytes to the area. Fibroblasts, the main cells that deposit<unk> , depend on oxygen to proliferate and lay down the new extracellular matrix. In vascularisation, also called angiogenesis, endothelial cells quickly grow into the<unk>  from older, intact blood vessels. These branch out in a systematic way, forming anastomoses with other vessels. Approximate times of the different phases of wound healing, with substantial variation depending on wound size and healing conditions.<unk>  formation is seen in green box at days to weeks.
Granulation tissue
Enema
Acellular dermis
Angiosome
Fibrocartilage callus
Ossification center
Nodular parenchyma
Neointima