<unk>  most commonly afflicts middle-aged (i.e. 49–57 years old) individuals<unk> ut has<unk> een diagnosed in persons aged 4 to 92 years. The disease has a male predominance ranging<unk> etween 1.7:1 to 3:1 in different studies. In a review of 36 reported pediatric cases, the male to female ratio was 4:1. Patients typically present with enlarged lymph nodes in the neck, arm pit, and groin areas<unk> ut on further examination are found to have involvement of their spleen (31% of cases), liver (52% of cases),<unk> one marrow (27% of cases) and lung/or (13%) as determined<unk> y finding enlarged spleens and/or livers on physical examination or medical imaging; abnormal results on liver function tests, and/or THRLBCL infiltrates in<unk> one marrow<unk> iopsies. Rare cases of the disease have presented with involvement of the skin (termed primary cutaneous THRLBCL), thyroid gland, thymus, gastrointestinal tract, pancreas, jaw<unk> one, nasopharynx,<unk> rain, tongue, uterus, stomach, and soft tissues. Many patients will also complain of having systemic<unk>  symptoms such as fever, night sweats, weight loss, and malaise.
T cell/histiocyte-rich large B-cell lymphoma
Diffuse large B-cell lymphoma associated with chronic inflammation
Germinal center B-cell like diffuse large B-cell lymphoma
Extranodal NK/T-cell lymphoma, nasal type
Fibrin-associated diffuse large B-cell lymphoma
Pediatric-type follicular lymphoma
Nodal marginal zone B cell lymphoma
Marginal zone B-cell lymphoma