<unk>  (also termed osteosclerotic myeloma, Crow–Fukase<unk> , Takatsuki disease, or PEP<unk>  is a rare paraneoplastic<unk>  caused by a clone of aberrant plasma cells. The name<unk>  is an acronym for some of the disease's major signs and symptoms (polyneuropathy, organomegaly, endocrinopathy, myeloma protein, and skin changes), as is PEP (polyneuropathy, endocrinopathy, plasma cell dyscrasia). The signs and symptoms of most neoplasms are due to their mass effects caused by the invasion and destruction of tissues by the neoplasms' cells. Signs and symptoms of a cancer causing a paraneoplastic<unk>  result from the release of humoral factors such as hormones, cytokines, or immunoglobulins by the<unk> 's neoplastic cells and/or the response of the immune system to the neoplasm. Many of the signs and symptoms in<unk>  are due at least in part to the release of an aberrant immunoglobulin, i.e. a myeloma protein, as well as certain cytokines by the malignant plasma cells.<unk>  typically begins in middle age – the average age at onset is 50 – and affects up to twice as many men as women.
POEMS syndrome
AL amyloidosis
Monoclonal gammopathy of undetermined significance
Waldenström macroglobulinemia
Smouldering myeloma
AA amyloidosis
Secondary systemic amyloidosis
Multiple myeloma