<unk>  may start with attacks of migraine with aura or subcortical transient ischemic attacks or strokes, or mood disorders between 35 and 55 years of age. The disease progresses to subcortical dementia associated with pseudobulbar palsy and urinary incontinence. Ischemic strokes are the most frequent presentation of<unk> , with approximately 85% of symptomatic individuals developing transient ischemic attacks or stroke(s). The mean age of onset of ischemic episodes is approximately 46 years (range 30–70). A classic lacunar syndrome occurs in at least two-thirds of affected patients while hemispheric strokes are much less common. It is worthy of note that ischemic strokes typically occur in the absence of traditional cardiovascular risk factors. Recurrent silent strokes, with or without clinical strokes, often lead to cognitive decline and overt subcortical dementia. A case of<unk>  presenting as schizophreniform organic psychosis has been reported.
CADASIL
Canavan disease
Menkes disease
Familial British dementia
Familial Danish dementia
Tauopathy
White dot syndromes
Lewy body dementias