The<unk>  proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response such as DNA repair. Activity of<unk>  protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns<unk>  into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and<unk>  genes, leading to a fusion gene present in many cases of chronic myelogenous leukemia. The DNA-binding activity of the ubiquitously expressed<unk>  tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for<unk> . The<unk>  gene is expressed as either a 6- or a 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.
ABL 
BRAF 
ZF2001
HAMLET 
P73
Bra
Ze339
SV40