While the cause of<unk>  remains unclear, current theory suggests that there may be a genetic predisposition as case reports have identified clusters of the disease and prevalence among twins. In fact, according to the Cleveland Clinic approximately 10% of cases appear to be inherited and often coexists with other genetic abnormalities that affect the blood vessels. Approximately 10% of patients with<unk>  have an affected family member. A study conducted from the patient registry at Michigan Cardiovascular Outcomes Research and Reporting Program (MCORRP) at the University of Michigan Health System reported a high prevalence of a family history of stroke (53.5%), aneurysm (23.5%), and sudden death (19.8%). Even though<unk>  is a non-atherosclerotic disease family histories of hypertension and hyperlipidemia were also common among those diagnosed with<unk> . It is believed that the cause of<unk>  is not a single identifier such as genetics but has multiple underlying factors. Theories of hormonal influence, mechanical stress from trauma and stress to the artery walls, and also the effect of loss of oxygen supply to the blood vessel wall caused by fibrous lesions. It has been suggested that environmental factors, such as smoking and estrogen, may play a role in addition to genetic factors, however concerns for safety associated with exogenous female hormones in<unk>  remain theorectical.
Fibromuscular dysplasia
Arteriosclerosis obliterans
Familial myxovascular fibromas
Endocardial fibroelastosis
Fibromatosis
Familial thoracic aortic aneurysm
Actinic elastosis
Collagen disease