<unk> , also known as hyperreactive malarial<unk> , occurs due immunological over-stimulation to repeated attacks of malarial infection over a long period of time. Condition is usually seen in malaria-endemic areas like Africa and Indian subcontinent.<unk>  is characterized by massive<unk> , hepatomegaly, marked elevations in levels of serum IgM and anti-malarial antibodies. The spleen is massively enlarged. It shows dilated sinusoids lined with reticulum cells. There is a marked erythrophagocytosis and lymphocytic infiltration of the pulp. Peripheral smear for malarial parasite is usually negative. Condition may show features of hypersplenism in severe form like anemia and thrombocytopenia. The treatment of<unk>  involve administration of antimalarial drug followed by prophylaxis for prolonged periods of time. This remove the add-on antigenic stimulus of repeated malarial infections and allow the reticuloendothelial system to return to normal.
Tropical splenomegaly syndrome
Refractory cytopenia of childhood
Refractory anemia with excess of blasts
Diffuse infiltrative lymphocytosis syndrome
Splenic marginal zone lymphoma
Bare lymphocyte syndrome
Prefibrotic primary myelofibrosis
EAST syndrome