<unk>  (C16H13Cl2NO4), chemically (2-{2, 6-dichlorophenyl) amino} phenylacetooxyacetic acid, is a crystalline powder with a molecular weight of 354.19. It is practically insoluble in water with good permeability. It is metabolized in human hepatocytes and human microsomes to form 2-(2',6'-dichloro-4'-hydroxy- phenylamino) phenyl acetoxyacetic acid as the major metabolite, which is then further conjugated. According to the Biopharmaceutical Classification System (BCS) drug substances are classified to four classes upon their solubility and permeability.<unk>  falls under the BCS Class II, poorly soluble and highly permeable drug.<unk>  works by inhibiting the action of cyclooxygenase (COX) that is involved in the production of prostaglandins (PG) which is accountable for pain, swelling, inflammation and fever. The incidence of gastric ulcerogenicity of<unk>  has been reported to be significantly lower than that of the other frequently prescribed NSAIDs, for instance, 2-folds lesser than naproxen, 4-folds lesser than diclofenac, and 7-folds lesser than indomethacin.
Aceclofenac
Ketoprofen
Diclofenac
Indoprofen
Loxoprofen
Fenoprofen
Celecoxib
Ibuprofen