Patients who are breastfeeding or plan to breastfeed should not take this medication as it may cause fetal harm.<unk>  is not recomnended in patients with a baseline eGFR less than or equal to 45 ml/min/1.73 m2 unless benefits exceeds risk. Dose should be reduced if the drug is used within this population as well as for patients who are hepatically impaired. Avoid the use of live attenuated vaccines when patients are on this medication. Avoid co-administration of<unk>  and other moderate to strong CYP3A4 inhibitors and if needed then reduce the dose of<unk> . Dosages of PgP-substrate drugs should be reduced if co-administered with<unk> .
Voclosporin
Dapsone
Ciclosporin
Caspofungin
Cortistatin 
Ketoconazole
Miconazole
Itraconazole