Treatment of DPGN depends on the severity of the disease. An optimal treatment for DPGN is immunosuppressive therapy. Two common immunosuppressive drugs used to treat DPGN are cyclophosphamide (CYC) and mycophenolate mofetil (MMF) if the DPGN is caused by SLE. CYC and MMF both preserve the renal function in patients with SLE and DPGN. CYC and MMF have been known to improve proteinuria. There can be adverse side effects; including CYC can cause infertility in both women and men. MMF has been seen to have less drug toxicity. There are a variety of dosing options (oral or intravenous medications) available. If the DPGN is caused by IgA nephropathy then corticosteroids, angiotensin-converting enzyme inhibitor (ACEIs), angiotensin receptor blockers (ARBs), or both ACEIs and ARBs should be used. Corticosteroids are used to suppress the immune system and to reduce inflammation. ACEIs will decrease hypertension by preventing the body from creating angiotensin II, which narrows the blood vessels. ARBs block angiotensin II from acting. The patient's diet should also be changed. The patient should restrict salt intake to improve the hypertension and nephrosis. Protein restriction may reduce the progression of the disease. Fluid restriction may also be necessary if the patient is experiencing edema. Renal corpuscle with many details including the glomerulus, glomerular capillaries, and Bowman's capsule.The glomeruli are filters in the kidneys. It is when the glomeruli become inflamed and stop filtering correctly when a person can get a type of glomerulonephritis.
Diffuse proliferative nephritis
Shunt nephritis
Focal proliferative nephritis
Lupus nephritis
Membranous glomerulonephritis
IgA nephropathy
Trench nephritis
Acute proliferative glomerulonephritis