Pharmacodynamics<unk>  is an antagonist of the AR, the biological target of androgens like testosterone and DHT. Fluridil binds to the androgen receptor with approximately a 9-15-fold higher affinity than more primitive NSAAs such as bicalutamide and hydroxyflutamide, but more research is required to validate these findings. +Percentage androgen receptor suppression in LNCaP Cells after 48-h Drug Incubation via Western Blot Compound 3 μM 10 μM BP-766<unk>  41 ± 5 95.9 ± 6 BP-521 62 ± 7 100 BP-34 3 ± 4 2 ± 2 Bicalutamide 3 ± 3 11 ± 3 Hydroxyflutamide 2 ± 6 6 ± 7 Pharmacokinetics<unk>  is a topical medication and is applied to the scalp.<unk>  degrades in human serum at 37 °C with a half-life of approximately 6 hours and is undetectable after 48 hours. Perfluoroacylamido-arylpropanamides decompose hydrolytically to BP-34 and their corresponding perfluorocarboxylic acid. In the case of<unk> , that perfluorocarboxylic acid is trifluoroacetic acid. The two metabolites of<unk>  namely BP-34 and trifluoroacetic acid were undetectable in human serum (below the detection limit of 5 ng/mL) along with the parent compound<unk> , in human studies. BP-34 was shown to be devoid of anti-androgenic activity.
Topilutamide
Bicalutamide
Darolutamide
Acetothiolutamide
Nilutamide
Apalutamide
Flutamide
Enzalutamide