Physical properties<unk>  is a triazole and benzodiazepine derivative substituted with a phenyl group at position 6, with a chlorine atom at position 8 and with a methyl group at position 1. It is an analogue of triazolam, the difference between them being the absence of a chlorine atom in the ortho position of the phenyl ring. It is slightly soluble in chloroform, soluble in alcohol, slightly soluble in acetone and insoluble in water. It has a melting point of . Synthesis For the synthesis of<unk>  the same method can be used as for triazolam, excepting that it starts from 2-amino-5-chlorobenzophenone. However, an alternative easier synthesis starting with 2,6-dichloro-4-phenylquinoline has been suggested, in which it reacts with hydrazine giving 6-chloro-2-hydrazino-4-phenylquinoline. Boiling the mixture with triethyl orthoacetate results in cyclization with the formation of the triazole ring. The product undergoes oxidative degradation in the presence of periodate and ruthenium dioxide in acetone solution, giving 2-4-(3'-methyl-1,2,4-triazolo)-5-chlorobenzophenone. Oxy-methylation with formaldehyde results in a product that is treated with phosphorus tribromide, when 2-4-(3'-methyl-5'-bromomethyl-1,2,4-triazolo)-5-chlorobenzophenone is obtained. By substituting the bromine atom with an amino group conferred by ammonia, it forms<unk>  triazolobenzophenone, following which an intermolecular heterocyclization takes place to obtain<unk> . Detection Quantification of<unk>  in blood and plasma samples may be necessary to confirm a diagnosis of intoxication in hospitalized patients, or to provide evidence in the case of crimes e.g., impaired driving arrest, or to assist in a thorough forensic investigation, e.g., in a medicolegal death investigation. Blood or plasma<unk>  concentrations are usually in a range of 10–100 μg/L in persons receiving the drug therapeutically, 100–300 μg/L in those arrested for impaired driving, and 300–2,000 μg/L in victims of acute overdosage. Most of the commercial immunoassays used for the benzodiazepine class of drugs cross-react with<unk> , but confirmation and quantitative determination are usually done by chromatographic techniques.
Alprazolam
Loprazolam
Clotiazepam
Clonazepam
Phenazepam
Diclazepam
Medazepam
Pinazepam