<unk>  is altered under various pathophysiological conditions. Sickle-cell disease is characterized by extensive impairment in<unk> , being dependent on the oxygen partial pressure.<unk>  has also been demonstrated to be impaired in diabetes, peripheral vascular diseases, sepsis and a variety of other diseases. The property offers broad utility in disease diagnosis (also see Measurement, below). Stored packed red blood cells (sometimes denoted "pRBC" or "StRBC") also experience changes in membrane properties like<unk>  during storage and related processing, as part of a broader phenomenon known as "storage lesion." While the clinical implications are still being explored,<unk>  can be indicative of quality or preservation thereof for stored RBC product available for blood transfusion. Perfusion (or perfusability) is a<unk> -based metric that may offer a particularly physiologically-relevant representation of storage-induced deterioration of RBC occurring in blood banks, and the associated impacts of storage conditions/systems.
Erythrocyte deformability
Platelet adhesiveness
Inflammatory cytokine
Total complement activity
Overall hemostatic potential
Vascular permeability
Blood protein
Mean corpuscular hemoglobin concentration