A clinical suspicion for<unk><unk>  can be made in patients with: 1. recurrent venous thromboembolic disease, 2. childhood thrombosis, 3. thrombosis in pregnancy. Testing for<unk>  activity can confirm<unk>  if the levels are less than 70%.<unk>  can result from genetic predisposition or from acquired causes such as: acute thrombosis, disseminated intravascular coagulopathy, liver disease, nephrotic syndrome, asparaginase<unk> , oral contraception/estrogens. Genetic testing for abnormalities of the SERPINC1 gene can be done to evaluate further.
Antithrombin III deficiency
Factor VII deficiency
Factor XIII deficiency
Protein C deficiency
Factor I deficiency
Factor X deficiency
Protein S deficiency
Factor XII deficiency