Signs and symptoms depend on the targeted antigen, but the features in patients with different antibodies often overlap. The most characteristic feature found in a case series was cognitive impairment and seizures in anti-LGI-1 positive patients, and peripheral motor hyperexcitability in anti-CASPR2 positive patients. anti-LGI-1<unk> : Patients with anti-LGI1<unk>  have limbic<unk>  with amnesia and/or confusion (100%) and seizures (84-92 %) Other reported features include hyponatremia (in 60%), movement disorders (myoclonus/dyskinesia), sleep disorders (hypersomnia, insomnia, REM sleep behavior disorder, sleep reversal) and ataxia. Tonic seizures, with movements of the leg, arm or face, refractory to treatment with anti-epileptic drugs may precede the disorders, and should lead to testing for anti-LGI1 antibodies. Anti-CASPR2 nervous system manifestations: Patients with anti-CASPIR2 antibodies develop symptoms from the CNS and/or the peripheral nervous system. The classic presentation is with Morvan’s syndrome, a disease with the features of neuromyotonia (i.e. peripheral hyperexcitability) and limbic<unk> . Other patients present with isolated neuromyotonia or limbic<unk> .Patients with anti-DPPX<unk>  present with symptoms of hyperexcitability such as agitation, tremor, muscle rigidity and gastrointestinal symptoms.
Anti-VGKC-complex encephalitis
Anti-NMDA receptor encephalitis
Anti-Hu associated encephalitis
Anti-neurofascin demyelinating diseases
Lymphocytic meningoradiculitis
Limbic encephalitis
Powassan encephalitis
Autoimmune encephalitis