<unk>  is practically insoluble in water, but very soluble in most organic solvents like ethanol (66.18g/100mL at 40°C for 90% EtOH), methanol, acetone and dichloromethane. The original synthesis of<unk>  by the Boots Group started with the compound 2-methylpropylbenzene. The synthesis took six steps. A modern, greener technique for the synthesis involves only three steps. Stereochemistry 200px 200px 200px 200px (R)-ibuprofen (S)-ibuprofen<unk> , like other 2-arylpropionate derivatives such as ketoprofen, flurbiprofen and naproxen, contains a stereocenter in the α-position of the propionate moiety. The product sold in pharmacies is a racemic mixture of the S and R-isomers. The S (dextrorotatory) isomer is the more biologically active; this isomer has been isolated and used medically (see dexibuprofen for details). The isomerase enzyme, alpha-methylacyl-CoA racemase, converts (R)-ibuprofen into the (S)-enantiomer.
Ibuprofen
Ketoprofen
Fenoprofen
Indoprofen
Loxoprofen
Meloxicam
Lornoxicam
Celecoxib