<unk>  is classified as primary, secondary, and tertiary; this is useful, but people often have a mix of stages. Within 9–90 days (but usually about 21 days) of infection, a painless but distinctive "mother yaw" nodule appears. Initially reddened and inflamed, it may become a papilloma, which can then become an ulcer, possibly with a yellow crust. Mother<unk>  are most commonly found on the legs and ankles, and are rarely found on the genitals (unlike syphilis) The mother yaw enlarges and becomes warty in appearance. Nearby "daughter<unk> " may also appear simultaneously. This primary stage resolves completely, with scarring, within 3–6 months. The scar is often pigmented. File:10.1177 0956462414549036-fig3-Papilloma of primary<unk> .Papilloma mother yaw File:Clinical presentation of skin NTDs tropicalmed-03-00120-g001 (cropped to<unk> .Mother yaw nodule with central ulceration and a yellow crust File:10.1177 0956462414549036-fig2-Ulcer of primary<unk> .Ulcerated mother yaw File:10.1177 0956462414549036-fig1-Ulcer of primary<unk> .Ulcerated mother yaw File:10.1177 0956462414549036-fig8-Primary<unk> , healed Lesion.Healed primary yaw lesion, showing pigmented scar The secondary stage occurs months to two years later (but usually 1–2 months later), and may thus begin when the mother yaw has not yet healed. It happens when the bacterium spreads in the blood and lymph. It begins as multiple, pinhead-like papules; these initial lesions grow and change in appearance and may last weeks before healing, with or without scarring. Secondary<unk>  typically shows widespread skin lesions that vary in appearance, including "crab<unk> " (areas of skin of abnormal colour) on the palms of the hands and soles of the feet (named for the crab-like gait they cause people with painful soles to assume). These may show desquamation. These secondary lesions frequently ulcerate and are then highly infectious, but heal after 6 months or more. Secondary<unk>  affects the skin and bones. The most common bone-related problem is periostitis, an inflammation around the bone, often occurs in the bones of the fingers and the long bones of the lower arms and legs, causing swollen fingers and limbs. This causes pain at night and thickening of the affected bones (periostitis). About 75% of infected children surveyed in Papua New Guinea reported joint pain. Swollen lymph nodes, fever, and malaise are also common. After primary and secondary<unk>  (and possibly, in some cases, without these phases), a latent infection develops. Within five years (rarely, within ten years) it can relapse and become active again, causing further secondary lesions, which may infect others. These relapse lesions are most commonly found around the armpits, mouth, and anus. File:Hypopigmented patches with overlying pink papules with central depressions.Secondary<unk>  begin as multiple small lesions. 10.1177 0956462414549036-fig4-Secondary<unk> - multiple small ulcerative lesions.The small lesions grow. 10.1177 0956462414549036-fig5-Secondary<unk> - maculo-papular lesions with scaling.Secondary lesions vary in appearance (see list of terms) File:Papulosquamous plaque and yellow-crusted nodules of secondary<unk>  on the leg (far view and close-up).Here two different appearances (papulosquamous plaque and yellow-crusted nodules) are seen in the same 10-year-old person (large-scale of both, close-up of nodules) File:Black-crusted erosion and surrounding hypopigmented patch on elbow.Hypopigmentation and an crusted erosion, elbow of a 5-year-old File:Large, hypopigmented patches topped with scaly pink and brown papules on the dorsa of feet and ankles.Secondary<unk> ; hypopigmented areas of skin topped with pink and brown papules, 9-year-old File:Plantar yaw with moist yellow crusted erosion overlying pink granulation tissue.Erosion on the sole of the foot, close-up (large-scale). If deeper, it would be an ulcer File:Moist, thick yellow crusted pink papilloma, 9-year-old boy.Secondary<unk>  papilloma (same 9-year-old as pictures of feet) File:4150843630 bc699a7fa4 bPian.Secondary breakout in a Javanese child age of 12 years. Wax model File:Scars of<unk>  lesions on the legs of a female patient with a history of<unk>  skin lesions in childhood and positive non-treponemal and treponemal antibodies (latent<unk> .Secondary<unk>  scars in an adult with childhood history of<unk>  An estimated 10% of people with<unk>  formerly were thought to develop tertiary disease symptoms, but more recently, tertiary<unk>  has been less frequently reported. Tertiary<unk>  can include gummatous nodules. It most commonly affects the skin. The skin of the palms and soles may thicken (hyperkeratosis). Nodules ulcerating near joints can cause tissue death. Periostitis can be much more severe. The shinbones may become bowed (saber shin) from chronic periostitis.<unk>  may or may not have cardiovascular or neurological effects; definitive evidence is lacking. Rhinopharyngitis mutilans Rhinopharyngitis mutilans, also known as gangosa, is a destructive ulcerative condition that usually originates about the soft palate and spreads into the hard palate, nasopharynx, and nose, resulting in mutilating cicatrices, and outward to the face, eroding intervening bone, cartilage, and soft tissues. It occurs in late stages of<unk> , usually 5 to 10 years after first symptoms of infection. This is now rare. Very rarely,<unk>  may cause bone spurs in the upper jaw near the nose (gondou); gondou was rare even when<unk>  was a common disease. File:Medical diagnosis for the student and practitioner (1922) (14761746096).Deep ulceration occurs in tertiary<unk>  File:Medical diagnosis for the student and practitioner (1922) (14804596673).Severe tertiary<unk> ; gangosa File:Medical diagnosis for the student and practitioner (1922) p1117 (cropped to goundu).Goundu, a very rare<unk> -caused deformity around the nose
Yaws
Enanthem
Scrubs 
Exanthem
Chilblains
Tuberculosis hut
Scabies
Saddle sore