Figure 1 HIV entry into CD4+ cell via<unk>  co-receptor. HIV enters host cells in the blood by attaching itself to<unk> s on the surface of the CD4+ cell. Viral entry to the CD4+ cell begins with attachment of the R5 HIV-1 glycoprotein 120 (gp120) to the CD4+ T-cell<unk> , which produces a conformational change in gp120 and allows it to bind to<unk> , thereby triggering glycoprotein 41 (gp41) mediated fusion of the viral envelope with the cell membrane and the nucleocapsid enters the host cell (Figure 1).<unk>  co-receptor antagonists prevent HIV-1 from entering and infecting immune cells by blocking<unk>  cell-surface<unk> . Small molecule antagonists of<unk>  bind to a hydrophobic pocket formed by the transmembrane helices of the<unk><unk> . They are thought to interact with the<unk>  in an allosteric manner locking the<unk>  in a conformation that prohibits its co-receptor function.
CCR5 receptor antagonist
CXCR4 antagonist
Tissue factor pathway inhibitor
Protein kinase inhibitor
TNF inhibitor
C-Met inhibitor
COX-2 inhibitor
Growth factor receptor inhibitor