<unk>  <unk>  is a congenital malformation of the midface. For the diagnosis of<unk> , a patient should present at least two of the following characteristics: hypertelorism (an increased distance between the eyes), a wide nasal root, vertical midline cleft of the nose and/or upper lip, cleft of the wings of the nose, malformed nasal tip, encephalocele (an opening of the skull with protrusion of the brain) or V-shaped hair pattern on the forehead. The cause of<unk>  remains unknown.<unk>  seems to be sporadic (random) and multiple environmental factors are suggested as possible causes for the syndrome. However, in some families multiple cases of<unk>  were reported, which suggests a genetic cause of<unk> .
Frontonasal dysplasia
Craniofrontonasal dysplasia
Oral submucous fibrosis
Hereditary mucoepithelial dysplasia
Nevoid basal-cell carcinoma syndrome
Genodermatosis
Neurofibromatosis
Neurofibromatosis type I