Chromosome 12 SCADD is caused genetically by mutations in the ACADS gene, located on chromosome 12q22-qter. Mutations in the ACADS gene lead to inadequate levels of<unk><unk> <unk> -CoA dehydrogenase, which is important for breaking down<unk><unk>  fatty acids. Low levels of this enzyme halt<unk><unk>  fatty acids from being further broken down and processed in the mitochondria, consequently, these<unk><unk>  fatty acids are not converted into energy. The disorder is inherited via autosomal recessive. This means the defective gene responsible for the disorder is located on an autosome (chromosome 12 is an autosome), and two copies of the defective gene are needed in order to be born with this disorder. The parents of an individual with an autosomal recessive disorder both carry one copy of the defective gene.
Short-chain acyl-coenzyme A dehydrogenase deficiency
Very long-chain acyl-coenzyme A dehydrogenase deficiency
Medium-chain acyl-coenzyme A dehydrogenase deficiency
Long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency
3-hydroxyacyl-coenzyme A dehydrogenase deficiency
2-Methylbutyryl-CoA dehydrogenase deficiency
Multiple carboxylase deficiency
3-Methylcrotonyl-CoA carboxylase deficiency