<unk>  progresses through five stages: * Stage I * Vasoconstrictive rash on palms of hands and feet * Persistent, heavy vomiting that is not relieved by not eating * Generalized lethargy * Confusion * Nightmares * No fever usually present * Headaches * Stage II * Stupor * Hyperventilation * Fatty liver (found on biopsy) * Hyperactive reflexes * Stage III * Continuation of Stage I and II symptoms * Possible coma * Possible cerebral edema * Rarely, respiratory arrest * Stage IV * Deepening coma * Dilated pupils with minimal response to light * Minimal but still present liver dysfunction * Stage V * Very rapid onset following stage IV * Deep coma * Seizures * Multiple organ failure * Flaccidity * Hyperammonemia (above 300 mg/dL of blood) * Death
Reye syndrome
Zaki syndrome
Kenny-Caffey syndrome
Mungan syndrome
Karak syndrome
Akureyri disease
Sotos syndrome
Eiken syndrome