A<unk>  or downregulator (SERD) is a type of drug which binds to the estrogen receptor (ER) and, in the process of doing so, causes the ER to be<unk>  and thus downregulated. They are used to treat estrogen receptor-sensitive or progesterone receptor-sensitive breast cancer, along with older classes of drugs like selective estrogen receptor modulators (SERMs) and aromatase inhibitors. As of 2016 the only marketed SERD was fulvestrant (brand name Faslodex). As of November 2016 other SERDs under development include brilanestrant and elacestrant. The clinical success of fulvestrant led to efforts to discover and develop a parallel drug class of selective androgen receptor<unk> s (SARDs).
Selective estrogen receptor degrader
Selective androgen receptor degrader
Steroidal aromatase inhibitor
Selective androgen receptor modulator
Selective estrogen receptor modulator
Aromatase inhibitor
Antiestrogen
N-Terminal domain antiandrogen