+<unk>  Site Ki (nM) 5-HT1A 617 5-HT2A 1.1 5-HT2C 48 5-HT5A 278 5-HT6 2414 5-HT7 2.7 α1A 2.5 α2A 3.9 α2C 2.7 D1 41 D2 1.6 D3 3.5 D4 54 D5 29 H1 19 H2 121 mACh >10,000 Values are Ki (nM). The smaller the value, the more strongly the drug binds to the site.<unk>  is the primary active metabolite of the older antipsychotic risperidone. While its specific mechanism of action is unknown, it is believed<unk>  and risperidone act via similar, if not identical, pathways. Its efficacy is believed to result from central dopaminergic and serotonergic antagonism. Food is known to increase the absorption of Invega type ER OROS prolonged-release tablets. Food increased exposure of<unk>  by up to 50-60%, however, half-life was not significantly affected. The effect was probably due to a delay in the transit of the ER OROS formulation in the upper part of the GI channel, resulting in increased absorption. risperidone and<unk>  in pharmacokinetics The half-life is 23 hours. Risperidone and its metabolite<unk>  are reduced in efficacy by P-glycoprotein inducers such as St John's wort
Paliperidone
Chlortalidone
Domperidone
Primidone
Ziprasidone
Fluparoxan
Rimonabant
Loprazolam