<unk>  is an autosomal dominant disorder. Genetic linkage gene mapping family studies localize the gene responsible for this disease to chromosome 5 at position q31-q33, between markers D5S642 and D5S816. Studies on other disorders associated with high levels of blood eosinophils (e.g. childhood asthma, schistosomiasis) have likewise linked eosinophilia to the q31-q33 area of chromosome 5. The 5q31-q33 region contains a cytokine gene cluster that includes genes for Interleukin 3, interleukin 5, and granulocyte-macrophage colony-stimulating factor. Each of these genes functions to promote the proliferation and differentiation of eosinophil precursor cells. Nonetheless, no gene polymorphisms were found within the promoters, exons, or introns of these 3 genes or in the regions' IL-3/GM-CSF enhancer. In addition to these studies, 8 affected members of a family with<unk>  had peripheral blood or bone marrow cells that carried the same chromosome abnormality, a pericentric inversion of chromosome 10, inv (10) (p11.2q21.2). The meaning and relationship, if any, of this inversion to<unk>  is unclear.
Familial eosinophilia
Tropical eosinophilia
Hypereosinophilic syndrome
Hereditary angioedema
Lymphocyte-variant hypereosinophilia
Mast cell activation syndrome
Drug reaction with eosinophilia and systemic symptoms
Mixed connective tissue disease