<unk>  <unk> , also known as<unk>  glomerular sclerosis” or<unk>  nodular<unk> ,” is a histopathologic finding of scarring (sclerosis) of glomeruli and damage to renal podocytes. This process damages the filtration function of the kidney, resulting in protein loss in the urine.<unk>  is a leading cause of excess protein loss--nephrotic syndrome—in children and adults. Signs and symptoms include proteinuria, water retention, and edema. Kidney failure is a common long-term complication of disease.<unk>  can be classified as primary versus secondary depending on whether a particular toxic or pathologic stressor can be identified as the cause. Diagnosis is established by renal biopsy, and treatment consists of glucocorticoids and other immune-modulatory drugs. Response to therapy is variable, with a significant portion of patients progressing to end-stage kidney failure.<unk>  is estimated to occur in 2-3 persons per million, with males and African peoples at higher risk .
Focal segmental glomerulosclerosis
Membranous glomerulonephritis
Minimal mesangial glomerulonephritis
Mesangial proliferative glomerulonephritis
Focal proliferative nephritis
IgA nephropathy
Mesoamerican nephropathy
Membranoproliferative glomerulonephritis