<unk>  (signet-ring cell type) x400, H&E stain<unk>  (dyscohesive<unk> ,<unk>  with a lack of intercellular connections) is a malignant tumour of epithelial origin, characterized by diffuse distribution of tumour cells, isolated from each other or in small groups. According to most recently endorsed classification of tumours, established by the World Health Organization/International Agency for Research on Cancer, this term is most appropriate to describe this kind of neoplasm and has its own ICD-O code: 8490/3 in the mentioned classification system. In the specialized literature can also be found such synonyms as "diffuse<unk> ", "diffuse infiltrative<unk> ." Signet-ring cell gastric<unk> , previously regarded as an independent type of tumor, today is a special case of<unk><unk><unk> . Tumor cells can be signet-ring type, that have a rounded shape with eccentrically located nucleus, resulting in large amounts of intracellular mucin. They may resemble lymphocytes, histiocytes, and plasma cells. Distribution of cells usually diffuse, they can form small groups of bands of gland-like structures with a conspicuous desmoplastic reaction of stroma. Can be combined with tubular or micropapillary types of tumor tissue. Pathohistological report of<unk><unk><unk> " is appropriate in case when there is a prevalence of tumor cells with corresponding characteristics. This type of tumor is more common in young adults, in contrast to tubular and micropapillary<unk> s. In the etiology of the latter great role play environment, presence of Helicobacter pylori infection, the presence and degree of atrophy and intestinalisation. The etiology of<unk><unk><unk>  according to the vast majority of researchers is genetically determined, related to deficiency of E-cadherin synthesis. Grade of<unk><unk><unk>  is not evaluated by pathologists.
Poorly cohesive gastric carcinoma
Oesophagogastric junctional adenocarcinoma
Gastric lymphoma
Hereditary diffuse gastric cancer
Atrophic gastritis
Ceruminous adenocarcinoma
Hyperplastic polyp
Reactive gastropathy