The revised clinical criteria for the diagnosis of<unk> 's<unk>  for an individual is dependent on either one of the following: 1.) 3 major criteria are met or more that must include macrocephaly, Lhermitte-Duclos, or GI hamartomas 2.) two major and three minor criteria. The major and minor criteria are listed below:<unk>  Diagnostic Criteria (Suggested by Pilarski et al) Major criteria Breast cancer Endometrial cancer (epithelial) Thyroid cancer (follicular) Gastrointestinal hamartomas (including ganglioneuromas, but excluding hyperplastic polyps; ≥3) Lhermitte-Duclos disease (adult) Macrocephaly (≥97 percentile: 58 cm for females, 60 cm for males) Macular pigmentation of the glans penis Multiple mucocutaneous lesions (any of the following): Multiple trichilemmomas (≥3, at least one biopsy proven) Acral keratoses (≥3 palmoplantar keratotic pits and/or acral hyperkeratotic papules) Mucocutaneous neuromas (≥3) Oral papillomas (particularly on tongue and gingiva), multiple (≥3) OR biopsy proven OR dermatologist diagnosed Minor criteria Autism spectrum disorder Colon cancer Esophageal glycogenic acanthosis (≥3) Lipomas (≥ 3) Mental retardation (ie, IQ ≤ 75) Renal cell carcinoma Testicular lipomatosis Thyroid cancer (papillary or follicular variant of papillary) Thyroid structural lesions (eg, adenoma, multinodular goiter) Vascular anomalies (including multiple intracranial developmental venous anomalies)
Cowden syndrome
Juvenile polyp
Laron syndrome
Fox–Fordyce disease
Jervell and Lange-Nielsen syndrome
Danon disease
Pott disease
Scott syndrome