<unk>  in isolation is asymptomatic. It is typically discovered in prostate biopsies taken to rule-out prostate cancer and very frequently seen in prostates removed for prostate cancer. Relation to prostate cancer There are several reasons why PIN is the most likely prostate cancer precursor. PIN is more common in men with prostate cancer.<unk><unk>  PIN can be found in 85 to 100% of radical<unk> tomy specimens, nearby or even in connection with prostate cancer. It tends to occur in the peripheral zone of the prostate. With age, it becomes increasingly multifocal, like prostate cancer. Molecular analysis has shown that<unk><unk>  PIN and prostate cancer share many genetic abnormalities. The risk for men with<unk><unk>  PIN of being diagnosed with prostate cancer after repeat biopsy has decreased since the introduction of biopsies at more than six locations (traditional sextant biopsies).
High-grade prostatic intraepithelial neoplasia
Benign prostatic hyperplasia
Asymptomatic inflammatory prostatitis
Histopathologic diagnosis of prostate cancer
Invasive urothelial carcinoma
Chronic bacterial prostatitis
Granulomatous prostatitis
Radiation proctitis