NF-2 LocusNF2 is a genetically transmitted condition. Diagnosis is most common in early adulthood (20–30 years); however, it can be diagnosed earlier.<unk>  can be diagnosed due to the presence of a bilateral vestibular schwannoma, or an acoustic neuroma, which causes a hearing loss that may begin unilaterally. If a patient does not meet this criterion of diagnosis, they must have a family history of<unk> , and present with a unilateral vestibular schwannoma and other associated tumors (cranial meningioma, cranial nerve schwannoma, spinal meningioma, spinal ependymomas, peripheral nerve tumor, spinal schwannoma, subcutaneous tumor, skin plaque). This being said, more than half of all patients diagnosed with<unk>  do not have a family history of the condition. Although it has yet to be included into clinical classification, peripheral neuropathy, or damage to the peripheral nerves, which often causes weakness, numbness and pain in the hands and feet, may also lead to a diagnosis of<unk> . In children,<unk>  can present with similar symptoms, but generally causes "visual disturbances (cataracts, hamartomas), skin tumors, mononeuropathhy (facial paresis, drop foot), symptomatic spinal cord tumors, or non-vestibular intracranial tumors". Prenatal Bilateral vestibular schwannomas are diagnostic of<unk> . Postnatal Ferner et al. give three sets of diagnostic criteria for<unk> : # Bilateral vestibular schwannoma (VS) or family history of<unk>  plus Unilateral VS or any two of: meningioma, glioma, neurofibroma, schwannoma, posterior subcapsular lenticular opacities # Unilateral VS plus any two of meningioma, glioma, neurofibroma, schwannoma, posterior subcapsular lenticular opacities # Two or more meningioma plus unilateral VS or any two of glioma, schwannoma and cataract. Another set of diagnostic criteria is the following: * Detection of bilateral acoustic neuroma by imaging-procedures * First degree relative with<unk>  and the occurrence of neurofibroma, meningiomas, glioma, or Schwannoma * First degree relative with<unk>  and the occurrence of juvenile posterior subcapsular cataract. The criteria have varied over time. The last revision of the<unk>  criteria was done by M.J. Smith in 2017. This included the consideration of a LZTR1 mutation (schwannomatosis) instead of<unk>  and excluded bilateral vestibular schwannomas that occur after 70 years of age.
Neurofibromatosis type II
Neurofibromatosis type 4
Tuberous sclerosis
Von Hippel–Lindau disease
Fox–Fordyce disease
Progeria
Fabry disease
Irlen syndrome