<unk> , also known as iris hamartoma, is a pigmented hamartomatous<unk> r aggregate of dendritic melanocytes affecting the iris, named after Austrian ophthalmologist Karl<unk>  (1907–1999), who first recognized them in 1937. The first published use of the term<unk>  was in the New England Journal of Medicine "Medical Progress" series article of December 31, 1981 (Riccardi VM: Von Recklinghausen Neurofibromatosis. N Engl J Med 1981;305:1617-27). These<unk> s are found in neurofibromatosis type 1, and are present in greater than 94% of patients over the age of six. They are clear, yellow-brown, oval to round, dome-shaped papules that project from the surface of the iris. These<unk> s typically do not affect vision, but are very useful in diagnosis. They are detected by slit lamp examination. Immunohistochemistry stains positive against the proteins vimentin and S-100, and points to an ectodermal origin for the<unk> s. Their precise origin and structure, however, are still under investigation. They can rarely be seen in neurofibromatosis type 2.
Lisch nodule
Rokitansky nodule
Synchysis scintillans
Hampton hump
Bankart lesion
Omphalolith
Maddox wing
Conduplicato corpore