Actin (Phalloidin) and Nuclei (DAPI) staining<unk>  cell cultured in plastic plate The<unk>  cell line was established in 1979 from bone metastasis of grade IV of prostate cancer in a 62-year-old Caucasian male. These cells do not respond to androgens, glucocorticoids or fibroblast growth factors, but results suggest that the cells are influenced by epidermal growth factors.<unk>  cells can be used to create subcutaneous tumor xenografts in mice to investigate the tumor environment and therapeutic drug functionality.<unk>  cells have high metastatic potential compared to DU145 cells, which have a moderate metastatic potential, and to LNCaP cells, which have low metastatic potential. Comparisons of the protein expression of<unk> , LNCaP, and other cells have shown that<unk>  is characteristic of small cell neoendocrine carcinoma.<unk>  cells have low testosterone-5-alpha reductase and acidic phosphatase activity, and do not express PSA (prostate-specific antigen). Furthermore, karyotypic analysis has shown that<unk>  are near-triploid, having 62 chromosomes. Q-band analysis showed no Y chromosome. From a morphological point of view, electron microscopy revealed that<unk>  cells show characteristics of a poorly-differentiated adenocarcinoma. They have features common to neoplastic cells of epithelial origins, such as numerous microvilli, junctional complexes, abnormal nuclei and nucleoli, abnormal mitochondria, annulate lamellae, and lipoidal bodies.
PC3
C-KAD
MCN
IPrEx
AP-7 
CARB-X
ACDC 
CURB-65