Micrograph of a lymph node affected by<unk> . H&E stain. High-magnification micrograph of<unk>  showing a granuloma (pale cells - right of center on image) and a microabscess with neutrophils (left of image), H&E stain The best diagnostic method available is polymerase chain reaction, which has a sensitivity of 43-76% and a specificity (in one study) of 100%. The Warthin–Starry stain can be helpful to show the presence of B. henselae, but is often difficult to interpret. B. henselae is difficult to culture and can take 2–6 weeks to incubate. Histology<unk>  is characterized by granulomatous inflammation on histological examination of the lymph nodes. Under the microscope, the skin lesion demonstrates a circumscribed focus of necrosis, surrounded by histiocytes, often accompanied by multinucleated giant cells, lymphocytes, and eosinophils. The regional lymph nodes demonstrate follicular hyperplasia with central stellate necrosis with neutrophils, surrounded by palisading histiocytes (suppurative granulomas) and sinuses packed with monocytoid B cells, usually without perifollicular and intrafollicular epithelioid cells. This pattern, although typical, is only present in a minority of cases.
Cat-scratch disease
Lymphogranuloma venereum
Diabetic dermadrome
Lymphoma
Tar melanosis
Sarcoidosis
Ichthyosis bullosa of Siemens
Brucellosis