PMSPH is not absorbed in the gastrointestinal tract and is excreted unchanged within 12 hours. A robust porous structure of the gel-forming matrix determines absorptive capacity of the mechanism of molecular adsorption and allows mostly to adsorb toxic substances and metabolites (e.g., bilirubin, protein breakdown products). Thanks to its gelly-like consistency, PMSPH: * absorbs macromolecular toxic substances by a mechanism of precipitation in the gel (e.g., bacterial toxins); * exhibits protective properties - elastic gelly-like drug particles form a layer on the mucosal surfaces. This layer protects the mucous membranes from exposure to various damaging factors, while its protective properties are manifested universally - in the intestine and on the mucosal surface of other organs. PMSPH absorbs toxic substances from the gastrointestinal tract as well as toxic substances (xenobiotics) trapped in the gastro-intestinal tract, from the surrounding environment. PMSPH also prevents reabsorption of toxins and metabolites spun into the lumen of the blood as well as transferred to the intestine with bile. PMS PH firmly binds and removes pathogenic bacteria. PMSPH possesses a pronounced ability to absorb lipopolysaccharide molecules. Large lipopolysaccharide molecules coprecipitate in the gel and are excreted. A daily dose of PMSPH binds 410 mg of Lipopolysaccharide (LPS), which has an extremely high biological activity. LPS can be found in the outer wall of gram-negative bacteria and is released only when the bacteria are destroyed, hence it is also called endotoxin (endo means "inside", inside the bacteria). The main reservoir of gram-negative microflora and lipopolysaccharide is the distal intestine. PMSPH is used in medicine, and the effectiveness of Enterosgel, a medicine containing PMSPH, has been proven in trials.
Polymethylsiloxane polyhydrate
Methyl cellulose
Alpha-Zearalenol
Beta-Zearalenol
Tetramethyl bisphenol F
Podophyllum resin
Bioactive glass
Chitosan