<unk> , sold under the brand name Ultram among others, is an opioid pain medication used to treat moderate to moderately severe pain. When taken by mouth in an immediate-release formulation, the onset of pain relief usually begins within an hour. It is also available by injection. It may be sold in combination with paracetamol (acetaminophen) or as longer-acting formulations, such as ULTRACET (37.5 mg<unk>  hydrochloride/ 325 mg acetaminophen tablets) As is typical of opioids, common side effects include constipation, itchiness, and nausea. Serious side effects may include hallucinations, seizures, increased risk of serotonin syndrome, decreased alertness, and drug addiction. A change in dosage may be recommended in those with kidney or liver problems. It is not recommended in those who are at risk of suicide or in those who are pregnant. While not recommended in women who are breastfeeding, those who take a single dose should not generally stop breastfeeding.<unk>  is converted in the liver to O-desmethyltramadol (desmetramadol), an opioid with a stronger affinity to the μ-opioid receptor.<unk>  is also a serotonin–norepinephrine reuptake inhibitor (SNRI).<unk>  was patented in 1963 and launched under the name "Tramal" in 1977 by the West German pharmaceutical company Grünenthal GmbH. In the mid-1990s, it was approved in the United Kingdom and the United States. It is available as a generic medication and marketed under many brand names worldwide. In 2019, it was the 35th most commonly prescribed medication in the United States, with more than 19million prescriptions.
Tramadol
Tapentadol
Desmetramadol
Hydrocodone
Etodolac
Ketorolac
Oxycodone
Acetylmethadol