The<unk> es have shared features of parkinsonism, impaired cognition, sleep disorders, and visual hallucinations.<unk> es can sometimes overlap with tauopathies, possibly because of interaction between the synuclein and tau proteins. REM sleep behavior disorder (RBD) is a parasomnia in which individuals with RBD lose the paralysis of muscles (atonia) that is normal during rapid eye movement (REM) sleep, and act out their dreams or have other abnormal movements or vocalizations. Abnormal sleep behaviors may appear decades before any other symptoms, often as an early sign of a<unk> . On autopsy, 94 to 98% of individuals with polysomnography-confirmed RBD are found to have a<unk> —most commonly DLB or PD. Other symptoms of the specific<unk>  usually manifest within 15 years of the diagnosis of RBD, but may emerge up to 50 years after RBD diagnosis. Alpha-synuclein deposits can affect the cardiac muscle and blood vessels. Almost all people with<unk> es have cardiovascular dysfunction, although most are asymptomatic. From chewing to defecation, alpha-synuclein deposits affect every level of gastrointestinal function. Symptoms include upper gastrointestinal tract dysfunction such as delayed gastric emptying or lower gastrointestinal dysfunction, such as constipation and prolonged stool transit time. Urinary retention, waking at night to urinate, increased urinary frequency and urgency, and over- or underactive bladder are common in people with<unk> es. Sexual dysfunction usually appears early in<unk> es, and may include erectile dysfunction, and difficulties achieving orgasm or ejaculating.
Synucleinopathy
Tauopathy
Central core disease
Synaptopathy
Lewy body dementias
Corticobasal degeneration
Neuroferritinopathy
Canavan disease