<unk>  (or aplasia) <unk> , also known as<unk> <unk>  agenesis, is a rare autosomal recessive genetic and endocrine syndrome affecting an estimated 1 in 1,000,000 genetic males. It is characterized by an inability of the body to respond to luteinizing hormone (LH), a gonadotropin which is normally responsible for signaling<unk> <unk> s of the testicles to produce testosterone and other androgen sex hormones. The condition manifests itself as pseudohermaphroditism (partially or fully underdeveloped genitalia), hypergonadotropic hypogonadism (decreased or lack of production of sex steroids by the gonads despite high circulating levels of gonadotropins), reduced or absent puberty (lack of development of secondary sexual characteristics, resulting in sexual infantilism if left untreated), and infertility.<unk>  does not occur in biological females as they do not have either<unk> <unk> s or testicles. However, the cause of the condition in males, luteinizing hormone insensitivity, does affect females, and because LH plays a role in the female reproductive system, it can result in primary amenorrhea or oligomenorrhea (absent or reduced menstruation), infertility due to anovulation, and ovarian cysts. A related condition is follicle-stimulating hormone (FSH) insensitivity, which presents with similar symptoms to those of<unk>  but with the symptoms in the respective sexes reversed (i.e., hypogonadism and sexual infantilism in females and merely problems with fertility in males). Despite their similar causes, FSH insensitivity is considerably less common in comparison to LH insensitivity.
Leydig cell hypoplasia
Müllerian agenesis
Androgen-induced hermaphroditism
Blighted ovum
Salivary gland hypoplasia
Salivary gland aplasia
Gonadotropin-releasing hormone insensitivity
Thyroid hormone resistance