The genes encoding aldosterone synthase and 11β-hydroxylase are 95% identical and are close together on chromosome 8. In individuals with<unk> , there is unequal crossing over so that the 5' regulatory region of the 11-hydroxylase gene is fused to the coding region of the aldosterone synthase. The product of this hybrid gene is aldosterone synthase that is ACTH-sensitive in the zona fasciculata of the adrenal gland. Although in normal subjects, ACTH accelerates the first step of aldosterone synthesis, ACTH normally has no effect on the activity of aldosterone synthase. However, in subjects with<unk> , ACTH increases the activity of existing aldosterone synthase, resulting in an abnormally high rate of aldosterone synthesis and hyperaldosteronism.
Glucocorticoid remediable aldosteronism
Primary aldosteronism
Familial hyperaldosteronism
Apparent mineralocorticoid excess syndrome
Pseudohypoaldosteronism
Pseudohyperaldosteronism
Renovascular hypertension
Cerebral salt-wasting syndrome