<unk> , or sometimes called pseudothalidomide syndrome, is an extremely rare autosomal recessive genetic disorder that is characterized by mild to severe prenatal retardation or disruption of cell division, leading to malformation of the bones in the skull, face, arms, and legs. It is caused by a mutation in the ESCO2 gene. It is one of the rarest autosomal recessive disorders, affecting approximately 150 known individuals. The mutation causes cell division to occur slowly or unevenly, and the cells with abnormal genetic content die.<unk>  can affect both males and females. Although the disorder is rare, the affected group is diverse. The mortality rate is high in severely affected individuals. The syndrome is named after American surgeon and physician John Bingham<unk>  (1852–1924), who first described it in 1919.
Roberts syndrome
Marden–Walker syndrome
Down syndrome
Renal dysplasia-limb defects syndrome
Hecht Scott syndrome
Trismus pseudocamptodactyly syndrome
Birk-Barel syndrome
Robinow syndrome