When<unk>  is associated with other features of coeliac disease, in particular positive antibodies, or HLA-DQ2/8 and a family history, treatment with a gluten-free diet produces an improvement in IEL numbers. Diarrhoea, thyroiditis, weakness and folate deficiency were other predictors of the development of gluten sensitivity and coeliac disease, which developed in 23 of 85 patients over 2 years in one series.
Duodenal lymphocytosis
Anti-gliadin antibodies
Generalized lymphadenopathy
Wandering spleen
Aberrant crypt foci
Black stomach
Pancreatic acinar metaplasia
Tonsil stones