Mechanism of action This drug's mechanism of action is not entirely clear. It inhibits the enzyme rho kinase. This appears to increase outflow of aqueous humor through the trabecular meshwork, and also to reduce pressure in the veins of the episcleral layer. The drug also inhibits the norepinephrine transporter. Pharmacokinetics After instillation into the eye,<unk>  is cleaved by esterases in the cornea to AR-13503, which is the active metabolite. Concentrations reached in the blood plasma are so low that they are generally not detectable. To judge from animal models, the drug acts for at least 24 hours. Its elimination half-life is 16 to 17 hours (in rabbits). AR-13503, the active metabolite
Netarsudil
Vosoritide
Ecallantide
Oprelvekin
Vagisil
Co-codaprin
Enarodustat
Lesinurad