Adverse effects of<unk>  include dependency, both physical and psychological; reduced sleep quality resulting in somnolence; and overdose, resulting in excessive sedation, impairment of balance and speech, respiratory depression or coma, and possibly death. Because of the latter,<unk>  is commonly used in suicide. When used in late pregnancy, it might cause hypotonia of the fetus. Dependence<unk> , as with other benzodiazepines, can lead to drug dependence. Discontinuation may result in benzodiazepine withdrawal syndrome, characterised by seizures, psychosis, insomnia, and anxiety. Rebound insomnia, worse than baseline insomnia, typically occurs after discontinuation of<unk>  even from short-term single nightly dose therapy. Paradoxical effects<unk>  may cause a paradoxical reaction in some individuals, including anxiety, aggressiveness, agitation, confusion, disinhibition, loss of impulse control, talkativeness, violent behavior, and even convulsions. Paradoxical adverse effects may even lead to criminal behaviour. Hypotonia Benzodiazepines such as<unk>  are lipophilic and rapidly penetrate membranes and, therefore, rapidly cross over into the placenta with significant uptake of the drug. Use of benzodiazepines including<unk>  in late pregnancy, especially high doses, may result in hypotonia, also known as floppy baby syndrome. Other<unk>  impairs cognitive functions. This may appear as lack of concentration, confusion and anterograde amnesia—the inability to create memories while under the influence. It can be described as a hangover-like effect which can persist to the next day. It also impairs psychomotor functions similar to other benzodiazepines and nonbenzodiazepine hypnotic drugs; falls and hip fractures were frequently reported. The combination with alcohol increases these impairments. Partial, but incomplete tolerance develops to these impairments. Other adverse effects include: * Slurred speech * Gastrointestinal disturbances, lasting 12 or more hours * Vomiting * Respiratory depression in higher doses Special precautions Benzodiazepines require special precaution if used in the elderly, during pregnancy, in children, in alcohol- or drug-dependent individuals, and in individuals with comorbid psychiatric disorders. Impairment of driving skills with a resultant increased risk of road traffic accidents is probably the most important adverse effect. This side-effect is not unique to<unk>  but also occurs with other hypnotic drugs.<unk>  seems to have a particularly high risk of road traffic accidents compared to other hypnotic drugs. Extreme caution should be exercised by drivers after taking<unk> .
Flunitrazepam
Flutoprazepam
Halazepam
Triazolam
Medazepam
Remimazolam
Amfepramone
Estazolam