<unk> , sold under the brand name Apresoline among others, is a medication used to treat high blood pressure and heart failure. This includes high blood pressure in pregnancy and very high blood pressure resulting in symptoms. It has been found to be particularly useful in heart failure, together with isosorbide dinitrate, for treatment of people of African descent. It is given by mouth or by injection into a vein. Effects usually begin around 15 minutes and last up to six hours. Common side effects include headache and fast heart rate. It is not recommended in people with coronary artery disease or in those with rheumatic heart disease that affects the mitral valve. In those with kidney disease a low dose is recommended.<unk>  is in the vasodilator family of medications, so it is believed to work by causing the dilation of blood vessels.<unk>  was discovered while scientists at Ciba were looking for a treatment for malaria. It was patented in 1949. It is on the World Health Organization's List of Essential Medicines. In 2019, it was the 99th most commonly prescribed medication in the United States, with more than 6million prescriptions.<unk>  has an adverse drug event of inducing drug-induced lupus and this drug's use is declining with more prescribers prescribing calcium channel blockers.
Hydralazine
Captopril
Chlorothiazide
Cyclothiazide
Furosemide
Metoprolol
Hydrochlorothiazide
Nebivolol