Heterozygous<unk>  occurs in 0.14–0.50% of the general population. Based on an estimated carrier rate of 0.2%, a homozygous or compound heterozygous<unk>  incidence of 1 per 4 million births could be predicted, although far fewer living patients have been identified. This low prevalence of patients with severe genetic<unk>  may be explained by excessive fetal demise, early postnatal deaths before diagnosis, heterogeneity in the cause of low concentrations of protein C among healthy individuals and under-reporting. The incidence of<unk>  in individuals who present with clinical symptoms has been reported to be estimated at 1 in 20,000.
Protein C deficiency
Activated protein C resistance
Factor VII deficiency
Protein S deficiency
COAT platelet defect
Factor XIII deficiency
Factor XII deficiency
Antithrombin III deficiency