A gene translocation<unk> etween chromosome 14 (containing the antibody heavy chain locus) and chromosome 18 (containing the<unk> CL-2 locus) is present in 45% of GCB DLBCLs<unk> ut has never<unk> een found in ABC DLBCLs. This T(14,18) translocation places the<unk> CL-2 gene close to the heavy chain gene enhancer and results in the overexpression of the<unk> cl-2 protein.<unk> cl-2 proteins prevent the activation of the caspases that lead to programmed cell death (apoptosis). Activation of the nuclear factor kappa-light-chain-enhancer of activated<unk> -cells (NF-κB) pathway is found only in ABC DLBCLs and not GCB DLBCLs. GCB DLBCL shows amplification of the oncogenic mir-17–92 microRNA cluster and deletion of the tumor suppressor PTEN<unk> ut these events have not<unk> een found in ABC DLBCL
Germinal center B-cell like diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma associated with chronic inflammation
Epstein–Barr virus positive diffuse large B-cell lymphoma, not otherwise specified
T cell/histiocyte-rich large B-cell lymphoma
Nodular lymphocyte predominant Hodgkin lymphoma
Extranodal NK/T-cell lymphoma, nasal type
Large B-cell lymphoma arising in HHV8-associated multicentric Castleman's disease
Pediatric-type follicular lymphoma