The American Association of Clinical Endocrinologists and the Royal College of Physicians recommend against the use of<unk><unk>  for the treatment of hypothyroidism. Concerns include the potential for adverse effects from superphysiological levels of T3 and the absence of long-term safety data from randomized clinical trials. They recommend levothyroxine as the preferred treatment. Some practitioners refuse to use<unk><unk> . About 65 mg of<unk><unk>  is equivalent to 100 μg of levothyroxine. Arguments against<unk><unk>  include:<unk><unk>  preparations have a greater variability from batch to batch than synthetic ones.<unk><unk>  has roughly a 4:1 ratio of thyroxine (T4) to triiodothyronine (T3). In humans, the ratio is 11:1. #A combination of various ratios of T4 and T3 might not provide benefits over T4 alone. Some controlled trials have shown inconsistent benefits of various ratios of T4 and T3. #The use of<unk><unk>  is usually accompanied with the practice of dosing according to symptoms instead of dosing to achieve "ideal" lab results (e.g. serum levels of TSH). While there is debate as to what the ideal serum levels are, dosing according to symptoms often results in higher dosages. Most endocrinologists are opposed to these higher dosages as there may be risks of hyperthyroidism and osteoporosis. #The preference for "natural" treatment seems to stem from philosophical belief as opposed to science. Arguments for<unk><unk>  include:<unk><unk>  contains all the natural<unk>  hormones produced exclusively by the<unk>  gland, including calcitonin which plays a crucial but still quite unclear role in promoting and sustaining bone density, however it is already used in therapy for osteoporosis when other treatments fail.<unk><unk>  therapy can be combined with synthetic thyroxine (T4) to balance out the T4/T3 correctly.
Desiccated thyroid extract
Hyoid suspension
Radioactive tracer
Lugol's iodine
Thyroidectomy
Brexucabtagene autoleucel
Tyrode's solution
Brompton cocktail