It is often asymptomatic in the early stages of<unk> . When the disease develops, a variety of signs can be observed in different body parts. For instance, patients may have pale skin, cold hands and feet, and numb fingertips. These are mainly due to the reduction in<unk>  flow to the limbs, resulting in a decrease in heat distribution to these areas. Ulcers and wounds would also take a much longer time to heal because of the impairment in<unk>  clot formation process. Muscle weakness and cramping may occur as well, especially in the legs, because of the insufficient oxygen supply to muscle cells for metabolism. Complications The vascular system strongly influences the condition of the heart. It is also vital in the rest of the body as the<unk><unk> s are in charge of carrying nutrients and the discard of metabolic wastes. Therefore,<unk>  can cause serious complications in the whole body. Coronary arteries are the<unk><unk> s that supply to the heart for its normal function.<unk> s occur in coronary arteries would affect cardiac activity. For instance, due to atherosclerosis, the plaque would obstruct and causes ischaemia - the reduction of<unk>  flow through the arteries. Ischaemia would then result in the decrease in oxygen supply to the heart, hence weaken the heart. It causes a vicious cycle as a weakened heart contraction would decrease<unk>  supply to the body, including cardiac muscle (muscle of heart). Moreover, if the plaque suddenly ruptures in the heart, it will cause a heart attack.
Blood vessel disorder
Vascular disease
Brain damage
Central nervous system disease
Vascular occlusion
Vascular anomaly
Pigmentation disorder
Neurological disorder