Laboratory findings Peripheral blood<unk>  (> 25 x 109/L) with myeloid precursors (promyelocytes, myelocytes, metamyelocytes) comprising less than 5% of leukocytes. Sites of involvement Peripheral blood, bone marrow, spleen, and liver are most common, but any organ or tissue can be infiltrated by neutrophils. Bone marrow biopsy On both the bone marrow aspirate and the core biopsy, a hypercellular marrow with an increased myeloid:erythroid ratio of 20:1 or greater. Myelocytes and neutrophils are increased, and blasts and promyelocytes are not increased. Due to the myeloproliferative nature of the disease, an increase in megakaryocytes and erythroid precursors may be observed, but dyspoiesis in not seen in any cell lineage. Also, reticulin fibrosis is rare. There is a reported association between<unk>  and multiple myeloma, so the bone marrow biopsy may show evidence of a plasma cell dyscrasia with increased numbers of atypical plasma cells. Spleen Splenic infiltrates are typically found only in the red pulp. Liver Hepatic infiltrates can be found in either the sinusoids, portal triad regions, or both. Immunophenotype No distinct immunophenotype abnormality for<unk>  has been described. See OHSU 2013 findings of gene CSF3R, mutation p. T6181
Chronic neutrophilic leukemia
Prolymphocytic leukemia
Leukemoid reaction
Chronic lymphocytic leukemia
Large granular lymphocytic leukemia
Mixed-phenotype acute leukemia
Acute monocytic leukemia
Acute myeloid leukemia