There are two subpopulations of T. b. gambiense that possesses two distinct groups that differ in genotype and phenotype. Group 2 is more akin to T. b.<unk>  than group 1 T. b. gambiense. All T. b. gambiense are resistant to killing by a serum component — trypanosome lytic factor (TLF) of which there are two types: TLF-1 and TLF-2. Group 1 T. b. gambiense parasites avoid uptake of the TLF particles while those of group 2 are able to either neutralize or compensate for the effects of TLF. In contrast, resistance in T. b. rhodesiense is dependent upon the expression of a serum resistance associated (SRA) gene. This gene is not found in T. b. gambiense. Genome The genome of<unk>  is made up of: *11 pairs of large chromosomes of 1 to 6 megabase pairs. *3–5 intermediate chromosomes of 200 to 500 kilobase pairs. *Around 100 minichromosomes of around 50 to 100 kilobase pairs. These may be present in multiple copies per haploid genome. Most genes are held on the large chromosomes, with the minichromosomes carrying only VSG genes. The genome has been sequenced and is available on GeneDB. The mitochondrial genome is found condensed into the kinetoplast, an unusual feature unique to the kinetoplastid protozoans. The kinetoplast and the basal body of the flagellum are strongly associated via a cytoskeletal structure In 1993, a new base, ß-d-glucopyranosyloxymethyluracil (base J), was identified in the nuclear DNA of<unk> .
Trypanosoma brucei
Trypanosoma evansi
Leishmania
Leishmania braziliensis
Trypanosoma cruzi
Plasmodium unalis
Leishmania donovani
Entamoeba moshkovskii