Screening for melanoma in FAMMM kindreds should begin at age 10 with a baseline total body skin examination including scalp, eyes, oral mucosa, genital area, and nail, as family members may develop melanoma in their early teens. Monthly self-performed skin examinations and early referral to a dermatologist for monitoring are recommended interventions. Treatment approaches such as removal of the largest<unk>  nevus or all of the<unk>  nevi have not been shown to appreciably reduce the risk of developing melanoma and are not cost-effective; therefore, these approaches are not recommended. Similarly, biopsy of multiple pigmented<unk>  nevi is not recommended and biopsy should be limited to specific nevi with appearance concerning for melanoma. At Mayo Clinic, FAMMM patients with a confirmed mutation and family history of pancreatic cancer are offered screening with either high-resolution pancreatic protocol CT, MRI, or endoscopic ultrasound starting at age 50 or 10 years younger than the earliest family member with pancreas cancer. They are counseled on the lack of evidence-based data to support screening, and on the limitations of our current technology to detect a lesion at a stage amenable to therapy.
Dysplastic nevus syndrome
Epidermal nevus syndrome
Spitz nevus
Vitiligo
Melanocytic nevus
Phakomatosis
Familial progressive hyperpigmentation
Smoker's melanosis