When higher doses are used, as in the treatment of toxoplasmosis,<unk>  can cause gastrointestinal symptoms such as nausea, vomiting, glossitis, anorexia, and diarrhea. A rash, which can be indicative of a hypersensitivity reaction, is also seen, particularly in combination with sulfonamides. Central nervous system effects include ataxia, tremors, and seizures. Hematologic side effects such as thrombocytopenia, leukopenia, and anemia can also occur.
Pyrimethamine
Quinine
Artemether
Phenpromethamine
Primaquine
Chloroquine
Mefloquine
Dimetacrine