<unk>  exerts bactericidal activities against susceptible gram-negative and gram-positive infections by inhibiting essential penicillin-binding proteins (PBPs), which are required for peptidoglycan cross-linking for bacterial cell wall synthesis, resulting in inhibition of cell wall synthesis and subsequent cell death.<unk>  is an inhibitor of PBPs of Pseudomonas aeruginosa (e.g. PBP1b, PBP1c, and PBP3) and E. coli (e.g., PBP3).<unk>  is a potent β-lactamase inhibitor of most common class A and C β-lactamases.<unk>  has little clinically relevant in vitro activity against bacteria due to its reduced affinity to penicillin-binding proteins; however, it is an irreversible inhibitor of some β-lactamases (certain penicillinases and cephalosporinases) and can covalently bind to some chromosomal and plasmid-mediated bacterial beta-lactamases. The addition of<unk>  strengthens the therapeutic response to<unk> , giving it the ability to treat a broader range of bacterial infections and resistant organisms.
Ceftolozane/tazobactam
Imipenem/cilastatin
Imipenem/cilastatin/relebactam
Ceftazidime/avibactam
Piperacillin/tazobactam
Ampicillin/sulbactam
Meropenem/vaborbactam
Tobramycin/dexamethasone