Patients who are diagnosed with general insulinoma are commonly treated with surgical removal of the insulinoma. But, in those patients with<unk>  surgery is not enough. Thus, medical therapies are widely considered and reserved for those especially with unresectable insulinoma. * Cytoreductive surgery * Diazoxide & Thiazide Diuretics * Beta-Blockers Cytoreductive surgery, alongside other anti-tumor therapies are part of the initial treatment plans utilized for potential removal of the insulinoma. But, in patients with<unk> , cytoreductive surgery has an effective rate of less than 10%. The surgery has however been shown to improve symptomatology and overall survival rate. Diazoxide is a medication used to primarily reduce the excess insulin secreted from the insulinoma cells. Insulin is suppressed by affecting the ATP-sensitive potassium channels. This can also lead to an excess of potassium and ultimately result in oedema from sodium retention in the body. In order to counteract this, Diazoxide is commonly used in combination with thiazide diuretics. Although Diazoxide has been noted to have an immediate effect on patients, over the course of time the dosage may need to be increased. Beta-blockers also have a positive effect in the overall reduction of insulin production. Therefore, resolving hypoglycemia.
Metastatic insulinoma
Glucagonoma
Insulinoma
Pancreatic neuroendocrine tumor
Adrenocortical adenoma
Granular cell tumor
Pituitary adenoma
Multiple endocrine neoplasia