In terms of the mechanism of<unk>  one sees that channel trafficking requires KATP channels need the shielding of ER retention signal.E282K prevents the KATP channel surface expression, the C-terminus (SUR1 subunit) is needed in KATP channel mechanism.R1215Q mutations (ABCC8 gene) affect ADP gating which in turn inhibits KATP channel.
Congenital hyperinsulinism
Leucine-sensitive hypoglycemia of infancy
Kosaki overgrowth syndrome
Idiopathic hypoglycemia
Insulinoma
Congenital adrenal hyperplasia
Lipoid congenital adrenal hyperplasia
Glucagonoma