<unk> s <unk> s) are a class of drugs used in the treatment of breast cancer in postmenopausal women and in men, and gynecomastia in men. They may also be used off-label to reduce estrogen conversion when supplementing testosterone exogenously. They may also be used for chemoprevention in women at high risk for breast cancer.<unk>  is the enzyme that catalyzes a key aromatization step in the synthesis of estrogen. It converts the enone ring of androgen precursors such as testosterone, to a phenol, completing the synthesis of estrogen. As hormone positive breast and ovarian cancers require estrogen to grow,<unk> s are taken to either block the production of estrogen or block the action of estrogen on receptors.
Aromatase inhibitor
Antiandrogen
5α-Reductase inhibitor
Antiestrogen
N-Terminal domain antiandrogen
Selective androgen receptor modulator
Selective estrogen receptor degrader
Selective androgen receptor degrader