The following is a list of symptoms that have been associated with<unk> : * Bilateral symmetric tetraphocomelia- a birth defect in which the hands and feet are attached to shortened arms and legs * Prenatal growth retardationAn example of a severely affected<unk>  Patient * Hypomelia (hypoplasia)- the incomplete development of a tissue or organ; less drastic than aplasia, which is no development at all * Oligodactyly- fewer than normal number of fingers or toes * Thumb aplasia- the absence of a thumb * Syndactyly- condition in which two or more fingers (or toes) are joined together; the joining can involve the bones or just the skin between the fingers * Clinodactyly- curving of the fifth finger (little finger) towards the fourth finger (ring finger) due to the underdevelopment of the middle bone in the fifth finger * Elbow/knee flexion contractures- an inability to fully straighten the arm or leg * Cleft lip- the presence of one or two vertical fissures in the upper lip; can be on one side (unilateral) or on both sides (bilateral) * Cleft palate- opening in the roof of the mouth * Premaxillary protrusion- upper part of the mouth sticks out farther than the lower part of the mouth * Micrognathia- small chin * Microbrachycephaly- smaller than normal head size * Malar hypoplasia- underdevelopment of the cheek bones * Downslanting palpebral fissures- the outer corners of the eyes point downwards * Ocular hypertelorism- unusually wide-set eyes * Exophthalmos- a protruding eyeball * Corneal clouding- clouding of the front-most part of the eye * Hypoplastic nasal alae- narrowing of the nostrils that can decrease the width of the nasal base * Beaked nose- a nose with a prominent bridge that gives it the appearance of being curved * Ear malformations * Intellectual disability * Encephalocele (only in severe cases)- rare defect of the neural tube characterized by sac-like protrusions of the brain Mortality is high among those severely affected by<unk> ; however, mildly affected individuals may survive to adulthood
Roberts syndrome
Marden–Walker syndrome
Down syndrome
Renal dysplasia-limb defects syndrome
Hecht Scott syndrome
Trismus pseudocamptodactyly syndrome
Birk-Barel syndrome
Robinow syndrome