Figure1.The<unk>  and p53 genes and their gene products. The arrows indicate the direction of transcription and the dotted lines the exon overlap between these genes. Figure 2. Functions of<unk> β Transcripts of<unk>  that overlap the first exon of p53 (referred to as<unk> α transcripts) regulate the levels of p53 mRNA and protein (Figure 1).<unk> γ transcripts overlap the first intron of p53 and are antisense to the previously identified transcript Hp53int1 localized within this intron. However, the function of<unk> γ remains elusive. The<unk>  gene also encodes a protein termed<unk> β (alias<unk>  or WDR79 or TCAB1), which belongs to the WD40 protein family (Figure 1).<unk> β facilitates protein-protein and protein-RNA interactions and directs factors to nuclear organelles Cajal bodies, to telomeres and to DNA double-strand breaks. Factors localized to Cajal bodies with the help of<unk> β includes the SMN protein, small Cajal body-specific scaRNAs and the enzyme telomerase.<unk> β also targets the ubiquitin ligase RNF8 to DNA double-strand breaks(Figure 2). In addition to localizing factors to correct cellular sites,<unk> β maintain structural integrity of Cajal bodies and without<unk> β these organelles collapse and cannot re-form (Figure 2). Domains == Figure 3. The structure of<unk> β. The numbers indicate amino acid residues. The<unk> β protein is highly evolutionary conserved, with homologs (confined to its WD40 repeats) in vertebrates, invertebrates, plants and yeast.<unk> β consists of a proline-rich N-terminus, a central WD40 domain and a glycine-rich C-terminus (Figure 3). The WD40 domain of<unk> β serves as a scaffold for multiple interactions between a wide variety of molecules.
WRAP53
ERCC2
CoWIN
KRAS
CDK13
INK4
TFM-4AS-1
FCER1