Mechanism of action<unk>  works by blocking the liver enzyme HMG-CoA reductase, which facilitates an important step in cholesterol synthesis. Pharmacodynamics In a Cochrane systematic review the dose-related magnitudes of<unk>  on blood lipids was determined. Over the dose range of 10 to 80 mg/day total cholesterol was reduced by 10.7% to 24.9%, LDL cholesterol by 15.2% to 34.9%, and triglycerides by 3% to 17.5%. Pharmacokinetics The drug is quickly and almost completely (98%) absorbed from the gut. Food intake slows down absorption, but does not decrease it. Due to its first-pass effect, bioavailability is lower: about 24–30% according to different sources. Over 98% of the substance is bound to plasma proteins. Several cytochrome P450 enzymes (mainly CYP2C9, but also CYP3A4 and CYP2C8) are involved in the metabolism of<unk> , which makes is less liable to interactions than most other statins. The main metabolite is inactive and is called "N-desisopropyl propionic acid" in the literature. 93–95% of the drug is excreted via the feces, less than 2% of which in form of the original substance.
Fluvastatin
Simvastatin
Ezetimibe
Lovastatin
Atorvastatin
Clofibrate
Pravastatin
Fenofibrate