The most frequently occurring adverse reactions (≥ 5% and greater than placebo) were nausea, headache, constipation, dizziness, insomnia, hot flush, hyperhydrosis, vomiting, palpitations, mouth rate increase, dry mouth, and hypertension FDA Savella prescribing information.<unk>  can have a significant impact on sexual functions, including both a decrease in sexual desire and ability.<unk>  can cause pain of the testicles in men. The incidence of cardiovascular and anticholinergic side effects was significantly lower compared to TCAs as a controlled study with over 3,300 patients revealed. Elevation of liver enzymes without signs of symptomatic liver disease has been infrequent. Mood swing to mania has also been seen and dictates termination of treatment. In psychotic patients emergence of delirium has been noticed.<unk>  has a low incidence of sedation but improves sleep (both duration and quality) in depressed patients. In agitated patients or those with suicidal thoughts additive sedative/anxiolytic treatment is usually indicated.
Milnacipran
Levomilnacipran
Tezacaftor
Damoctocog alfa pegol
Glysobuzole
Amivantamab
Naloxegol
Glybuzole