The median age of diagnosis is approximately late thirties to early forties. The estimates of childhood disease vary (8%, 15%, 30%) but it can be seen at any age. The disease usually arises in lymph nodes, particularly the neck, but extranodal involvement, including in the gastrointestinal tract, nasal cavity, ovary and brain, has been described. Morphologically, there are large immunoblast-like cells with large central nucleoli, often cellular clusters, with a predilection for the lymph node sinuses in a cohesive pattern that can suggest carcinoma cells.
ALK+ large B-cell lymphoma
Epstein–Barr virus positive diffuse large B-cell lymphoma, not otherwise specified
EML4-ALK positive lung cancer
Nodular lymphocyte predominant Hodgkin lymphoma
Fibrin-associated diffuse large B-cell lymphoma
Pediatric-type follicular lymphoma
RAS-associated autoimmune leukoproliferative disorder
CD30+ cutaneous T-cell lymphoma