<unk>  is a small glycoprotein with a molecular weight of approximately 15-16 kDa.<unk>  is secreted by activated monocytes/macrophages, T lymphocytes and endothelial cells.<unk>  binds to the chemokine receptor CCR8 and induces Ca2+ influx, chemotaxis and regulate apoptosis. CCR8 is constitutively expressed in monocytes/macrophages, Th2, and regulatory T lymphocytes. Thus,<unk>  mainly acts as a chemoattractant for monocytes/macrophages, T lymphocytes, specially Th2-differentiated T cells and a subset of T regulatory cells in vitro into inflammatory siter. It can also attract NK cells, immature B cells but do not attracts neutrophils.<unk>  stimulates a transient increase in the concentration of cytoplasmic free calcium in monocytes but not in other type of cells. Furthermore,<unk>  inhibits apoptosis in thymic cell lines by the RAS/MAPK pathway but can prevent dexamethasone-induced apoptosis in cultured murine thymic lymphoma cells.
CCL1
IFL 
OPCS-4
ANGPTL8
Major basic protein
STAT protein
Rho
NLRP3