Anxiety<unk> 's main clinical use is for the treatment of anxiety, and evidence points to it being as effective as other clinical anxiety drugs, in particular diazepam. In the treatment of symptoms of mild anxiety due to psychoneurosis, a daily dosage of 30 to 80 mg of<unk>  was shown to be just as effective as 6–20 mg of diazepam. In another study one group of patients were given 10 mg of<unk>  three times a day, while another group was given 5 mg of diazepam, and the treatments were equivalent. While these studies point to higher doses of<unk>  being needed to exert the same pharmacological effects, the drug is still popular because of its ability to act as an anxiolytic without producing the common respiratory depression associated with other sedative drugs. Some studies have even shown that it stimulates the respiratory system.<unk>  and sodium amylobarbitone In a study used to compare<unk>  to sodium amylobarbitone as a sleep promoter, it was found that during administration of both drugs, patients reported that their sleep was less restless, and drowsiness was diminished. The study further showed that while sodium amylobarbitone caused withdrawal rebound symptoms,<unk>  did not. It was also found that<unk>  reduced plasma corticosteroid hormone levels. There is a relationship between anxiety and adreno-corticosteroid activity, with raised levels commonly being reported as an indication of stress. The study showed that<unk> , a drug reported to reduce anxiety, was also able to reduce the hormones that potentially cause it. This points to a phenomenon often seen within pharmacology where drugs intended for other uses often have far-reaching and rarely considered effects.<unk>  vs. chlordiazepoxide in anxiety neurosis<unk>  has been found to have the same efficacy as chlordiazepoxide when treating anxiety neurosis Sleep sedation While<unk>  was made to be an alternative to the benzodiazepine line of anxiolytic drugs, other uses for the drug have been discovered. Due to<unk> 's ability to tranquilize without causing respiratory depression, scientists are moving forward with studies that test its sedative effects in patients with respiratory failure. In one study that used<unk>  in a clinical setting, researchers showed that the use of<unk>  for sedation did not result in changes in forced expiratory volume in one second or carbon dioxide partial pressure PCO2. This confirmed previous statements that claimed the drug did not cause respiratory failure. The main goal of this clinical study was to confirm the findings of another study that showed<unk>  did not reduce CO2 responsiveness, but instead increased the ventilatory response to CO2. There are usually many risks associated with using sedatives on patients who are suffering from respiratory failure, which has made it difficult to administer tranquillizing medications in situations when they are desirable. It is not known why this drug is safe and its benzodiazepine cousins are not, but a possible explanation for this phenomenon might come from its similarity in structure to tricyclic antidepressants, which have also been shown to not cause respiratory failure. While further experimentation is necessary, this study points to<unk> 's possible consideration for sedation in respiratory failure patients. Other uses Hypertension A possible treatment for hypertension is blocking peripheral vascular seretonergic neurons or alpha-adrenergic neurons on postsynaptic cell sites. One study showed that<unk> , a serotonin and alpha-adrenergic antagonist, does not reduce blood pressure through a seretonin mechanism but does reduce blood pressure by antagonizing alpha-adrenergic receptors in rats. Rats were given 10 mg of<unk>  and drops in their blood pressure were approximately 30 mm Hg. The researchers further confirmed that serotonin antagonism was not sufficient to reduce blood pressure by using the highly selective serotonin antagonist 1-(1-naphthyl)-piperazine, which was not able to decrease the blood pressure of the rats. These studies have yet to be repeated in humans.
Benzoctamine
Tesofensine
Bethanechol
Theobromine
Pseudoephedrine
L-Norpseudoephedrine
Ephedrine
Scopolamine