Mechanism of action<unk>  is an<unk> emisinin derivative and the mechanism of action for<unk> emisinins is.<unk>  interact with ferriprotoporphyrin IX (heme) or ferrous ions in the acidic parasite food vacuole, and generates cytotoxic radical species The accepted mode of action of the peroxide containing drug involve its interaction with heme (byproduct of hemoglobin degradation), derived from proteolysis of haemoglobin. This interaction results in the formation of toxic oxygen and carbon centered radicals. One of the proposed mechanisms is that through inhibiting anti-oxidant and metabolic enzymes,<unk> emisinin derivatives inflict oxidative and metabolic stress on the cell. Some pathways affected may concern glutathione and glucose metabolism. As a consequence, lesions and reduced growth of the parasite may result. Another possible mechanism of action suggests that<unk> eristinin drugs exert their cidal action through inhibiting PfATP6. Since PfATP6 is an enzyme regulating cellular calcium concentration, its malfunctioning will lead to intracellular calcium accumulation, which in turns causes cell death. Pharmacokinetics Absorption of<unk>  is improved 2- to 3-fold with food. It is highly bound to protein (95.4%). Peak concentrations of<unk>  are seen 2 hours after administration.<unk>  is metabolized in the human body to the active metabolite, dihydroartemisinin, primarily by hepatic enzymes CYP3A4/5. Both the parent drug and active metabolite are eliminated with a half-life of about 2 hours.
Artemether
Delamanid
Primaquine
Quinine
Piperaquine
Mefloquine
Tafenoquine
Proguanil