Mechanism of action<unk>  is lethal to P. vivax and P. ovale in the liver stage, and also to P. vivax in the blood stage through its ability to do oxidative damage to the cell. However, the exact mechanism of action is not fully understood. Pharmacokinetics<unk>  is well-absorbed in the gut and extensively distributed in the body without accumulating in red blood cells. Administration of<unk>  with food or grapefruit juice increases its oral bioavailibity. In blood, about 20% of circulating<unk>  is protein-bound, with preferential binding to the acute phase protein orosomucoid. With a half-life on the order of 6 hours, it is quickly metabolized by liver enzymes to carboxyprimaquine, which does not have anti-malarial activity. Renal excretion of the parent drug is less than 4%.
Primaquine
Tafenoquine
Amodiaquine
Artemether
Piperaquine
Mefloquine
Chloroquine
Delamanid