MRI scans of a patient with astrocytoma, showing the<unk> 's<unk>  between the incidental finding in 2007 and the onset of phenotypical changes in 2014.<unk>  is the third and last phase in<unk>  development. This phase is characterised by increased growth speed and invasiveness of the<unk>  cells. As a result of the<unk> , phenotypical changes occur and the<unk>  becomes more aggressive and acquires greater malignant potential. Together with the<unk> , more and more aneuploidy occurs. This may be evident as nuclear polymorphism.
Tumor progression
Degenerative disease
Bone decalcification
Malignant transformation
Precancerous condition
Myelonecrosis
Tissue stress
Ischemic compression