<unk>  (TCIs) or<unk><unk>  drugs are rationally designed inhibitors that bind and then bond to their target proteins. These inhibitors possess a bond-forming functional group of low chemical reactivity that, following binding to the target protein, is positioned to react rapidly with a proximate nucleophilic residue at the target site to form a bond. This illustration describes the mechanism by which<unk>  drugs irreversibly bind and modify the protein, e.g. silencing its activity
Targeted covalent inhibitors
Small molecule drug conjugate
MTOR inhibitors
Lipase inhibitors
COX-2 inhibitor
Pharmacological chaperone
TNF inhibitor
Topoisomerase inhibitor