<unk>  can be inherited or acquired. Decreased production Abnormally low platelet production may be caused by: * Dehydration, Vitamin B12 or folic acid deficiency * Leukemia, myelodysplastic syndrome, or aplastic anemia * Decreased production of thrombopoietin by the liver in liver failure * Sepsis, systemic viral or bacterial infection * Leptospirosis * Hereditary syndromes * ACTN1-related<unk>  * Amegakaryocytic<unk>  with radio-ulnar synostosis * ANKRD26 related<unk>  * Autosomal dominant<unk>  * Bernard–Soulier syndrome (associated with giant platelet disorder) * Congenital amegakaryocytic<unk>  * Congenital amegakaryocytic<unk>  and radioulnar synostosis * CYCS-related<unk>  * Epstein syndrome (associated with giant platelet disorder) * ETV6 related<unk>  * Fanconi anemia * Filaminopathies A * FYB related<unk>  * Glanzmann's thrombasthenia * GNE myopathy with congenital<unk>  * Gray platelet syndrome (associated with giant platelet disorder) * Harris platelet syndrome (associated with giant platelet disorder) * Macrothrombocytopenia and hearing loss * May–Hegglin anomaly (associated with giant platelet disorder) * MYH9-related disease (associated with giant platelet disorder) * PRKACG-related<unk>  * Paris-Trousseau<unk> /Jacobsen syndrome * Sebastian syndrome * SLFN14-related<unk>  * Stormorken syndrome * TRPM7-related<unk>  *<unk>  absent radius syndrome * Tropomyosin 4-related<unk>  * TUBB1-related<unk>  * Upshaw–Schulman syndrome * Wiskott–Aldrich syndrome * X-linked<unk>  * X-linked<unk>  with thalassemia Increased destruction TTP Abnormally high rates of platelet destruction may be due to immune or nonimmune conditions, including: * Immune<unk>  purpura * Thrombotic<unk>  purpura * Hemolytic–uremic syndrome * Disseminated intravascular coagulation * Paroxysmal nocturnal hemoglobinuria * Antiphospholipid syndrome * Systemic lupus erythematosus * Post-transfusion purpura * Neonatal alloimmune<unk>  * Hypersplenism * Dengue fever * Gaucher's disease * Zika virus Medication-induced These medications can induce<unk>  through direct myelosuppression: * Valproic acid * Methotrexate * Carboplatin * Interferon * Isotretinoin * Panobinostat * H2 blockers and proton-pump inhibitors Other causes * Lab error, possibly due to the anticoagulant EDTA in CBC specimen tubes; a citrated platelet count is a useful follow-up study * Snakebite * Niacin toxicity * Lyme disease * Thrombocytapheresis (also called plateletpheresis) * Niemann–Pick disease
Thrombocytopenia
Lymphocytopenia
Monocytopenia
Reticulocytopenia
Cytopenia
Lymphocytosis
Reticulocytosis
Plasmacytosis