Screening of immunoglobulin levels in relatives of CVID and IgA patients finds a familial inheritance rate of 10% to 20%. In cases where a carrier of such a mutation would like to have children, preimplantation genetic diagnosis (PGD) has been offered. PGD is defined as the testing of pre-implantation stage embryos or oocytes for genetic defects. It requires in vitro fertilization, embryo biopsy, and either fluorescent in situ hybridization or polymerase chain reaction on a singular cell, making it a complex procedure. While some question the ethicality of such artificial selection, it is generally seen as an important alternative to prenatal diagnosis. Prevention of secondary immunodeficiency involves monitoring patients carefully with high risk of developing<unk> . This entails measuring immunoglobulin levels in patients with hematologic malignancy, or those receiving chemotherapy or immunosuppressive therapy such as rituximab.
Hypogammaglobulinemia
Hypergammaglobulinemia
Dysgammaglobulinemia
Monocytopenia
Thymic hypoplasia
Monoclonal B-cell lymphocytosis
Lymphocytopenia
Splenomegaly