Although<unk>  is the most effective treatment for many forms of end-stage<unk>  disease, the tremendous limitation in allograft (donor) availability and widely variable post-surgical outcomes make case selection critically important. Assessment of a person's transplant eligibility is made by a multi-disciplinary team that includes surgeons, medical doctors, psychologists and other providers. The first step in evaluation is to determine whether the patient has irreversible<unk> -based disease which will be cured by getting a new<unk> . Thus, those with diseases which are primarily based outside the<unk>  or have spread beyond the<unk>  are generally considered poor candidates. Some examples include: * someone with advanced<unk>  cancer, with known/likely spread beyond the<unk>  * active alcohol/substance use * severe heart/lung disease * existing high cholesterol levels in the patient * dyslipidemia Importantly, many contraindications to<unk>  are considered reversible; a person initially deemed "transplant-ineligible" may later become a favorable candidate if their situation changes. Some examples include: * partial treatment of<unk>  cancer, such that risk of spread beyond<unk>  is decreased (for those with primary<unk>  cancer or secondary spread to the<unk> , the medical team will likely rely heavily on the opinion of the patient's primary provider, the oncologist, and the radiologist) * cessation of substance use (time period of abstinence is variable) * improvement in heart function, e.g. by percutaneous coronary intervention or bypass surgery * treated HIV infection (see Special populations) * for those with high cholesterol or triglyceride levels or other dyslipidemias, using lifestyle changes (diet, portions, exercise) and drugs and counseling to lower one's levels, and to control any hyperglycemia or (pre-)diabetes or obesity
Liver transplantation
Pancreas transplantation
Hepatoportoenterostomy
Percutaneous hepatic perfusion
Hepatic artery embolization
Biliary endoscopic sphincterotomy
Islet cell transplantation
Pancreatectomy