Electroencephalogram (EEG) displaying burst suppression patterns. Onset of bursts are indicated by solid arrows; offset, by open arrows. In both A and B, the interval between each vertical dotted line is one second The diagnosis is based on the clinical presentation and on typical electroencephalographic patterns based on time of onset. Typically, onset of seizures and spasms have been indicative of OS diagnosis, while MRI and Abormal EEG "burst suppression" pattern can confirm. Genetic testing with chromosomal microarray analysis followed by an epilepsy gene panel or whole exome sequencing may be considered after MRI imaging has been exhausted. Differential diagnoses between other epileptic encephalopathies such as West syndrome or Lennox-Gastaut syndrome are distinguished by myoclonic seizures and differences in spike-and-wave patterns on EEG.
Ohtahara syndrome
Pallister–Killian syndrome
Cohen syndrome
Cohen-Gibson syndrome
Berdon syndrome
Scheie syndrome
Gleich's syndrome
Christianson syndrome