<unk> , also known as subcortical leukoencephalopathy and subcortical arteriosclerotic encephalopathy (SAE), is a form of small vessel vascular dementia caused by damage to the white brain matter. White matter atrophy can be caused by many circumstances including chronic hypertension as well as old age. This disease is characterized by loss of memory and intellectual function and by changes in mood. These changes encompass what are known as executive functions of the brain. It usually presents between 54 and 66 years of age, and the first symptoms are usually mental deterioration or stroke. It was described by Otto<unk>  in 1894, and Alois Alzheimer first used the phrase<unk> " in 1902. However, Jerzy Olszewski is credited with much of the modern-day investigation of this disease which began in 1962.
Binswanger's disease
Borna disease
Gorham's disease
Darier's disease
Fox–Fordyce disease
Lev's disease
Tornwaldt's disease
Kienböck's disease