In the middle of the 20th century the principal treatment for some of the amino acid disorders was restriction of dietary protein and all other care was simply management of complications. In the past twenty years, enzyme replacement, gene therapy, and organ transplantation have become available and beneficial for many previously untreatable disorders. Some of the more common or promising therapies are listed:
Inborn errors of metabolism
Inborn errors of carbohydrate metabolism
Sphingolipidoses
Mitochondrial disease
GM1 gangliosidoses
Neonatal hemochromatosis
GM2 gangliosidoses
Congenital disorders of amino acid metabolism