The most important aspect of treatment is prompt and extensive surgical debridement of the involved area and excision of all devitalized tissue, in which the organisms are prone to grow. Administration of antimicrobial drugs, particularly penicillin, is begun at the same time. Hyperbaric oxygen may be of help in the medical management of clostridial tissue infections. It is said to “detoxify” patients rapidly.
Clostridium perfringens
Bacillus cereus
Clostridium botulinum
Clostridium tetani
Clostridium innocuum
Clostridioides difficile 
Campylobacter upsaliensis
Escherichia coli