The condition is suspected in an elderly person, especially male, presenting with symptoms of heart failure such as shortness of breath or swollen legs, and or disease of the electrical system of the heart with ensuing slow heart rate, dizziness or fainting spells. The diagnosis is confirmed on the basis of a biopsy, which can be treated with a special stain called Congo Red that will be positive in this condition, and immunohistochemistry. However, this disease can now non-invasively be diagnosed with the help of Tc-99m pyrophosphate scintigraphy.
Wild-type transthyretin amyloid
Alpha-synuclein
Amyloid beta
Immunoreactive trypsinogen
Anti-gliadin antibodies
Keratic precipitate
Kamino bodies
Anchoring fibrils