<unk>  is a "classical" benzodiazepine. Other classical benzodiazepines include chlordiazepoxide, diazepam, clonazepam, oxazepam, lorazepam, nitrazepam, bromazepam and flurazepam.<unk>  is a long-acting benzodiazepine drug.<unk>  produces the active metabolite desmethyl-diazepam, which is a partial agonist of the GABAA receptor and has a half life of 20 – 179 hours; a small amount of desmethyldiazepam is further metabolised into oxazepam.<unk>  exerts its pharmacological properties via increasing the opening frequency of the chloride ion channel of GABAA receptors. This effect of benzodiazepines requires the presence of the neurotransmitter GABA and results in enhanced inhibitory effects of the neurotransmitter GABA acting on GABAA receptors.<unk> , like other benzodiazepines, is widely distributed and is highly bound to plasma proteins;<unk>  also crosses readily over the placenta and into breast milk. Peak plasma levels of the active metabolite desmethyl-diazepam are seen between 30 minutes and 2 hours after oral administration of<unk> .<unk>  is completely metabolised to desmethyl-diazepam in the gastrointestinal tract and thus the pharmacological properties of<unk>  are largely due to desmethyldiazepam.
Clorazepate
Chlordiazepoxide
Domperidone
Halazepam
Delorazepam
Clotiazepam
Fludiazepam
Clonazepam