The diagnosis could be differentiated from other known psychoses and dementias by a characteristic abnormality in eye pupil reflexes (Argyll Robertson pupil), and, eventually, the development of muscular reflex abnormalities, seizures, memory impairment (dementia) and other signs of relatively pervasive neurocerebral deterioration. Definitive diagnosis is based on the analysis of cerebrospinal fluid and tests for syphilis.
General paresis of the insane
Hyperreflexia
Facial weakness
Triparesis
Abnormal posturing
Whispered pectoriloquy
Scalp dysesthesia
Hemiparesis