<unk>  <unk>  is a kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport primary urine.<unk>  is the most common type of kidney cancer in adults, responsible for approximately 90–95% of cases.<unk>  occurrence shows a male predominance over women with a ratio of 1.5:1.<unk>  most commonly occurs between 6th and 7th decade of life. Initial treatment is most commonly either partial or complete removal of the affected kidney(s). Where the cancer has not metastasised (spread to other organs) or burrowed deeper into the tissues of the kidney, the five-year survival rate is 65–90%, but this is lowered considerably when the cancer has spread. The body is remarkably good at hiding the symptoms and as a result people with<unk>  often have advanced disease by the time it is discovered. The initial symptoms of<unk>  often include blood in the urine (occurring in 40% of affected persons at the time they first seek medical attention), flank pain (40%), a mass in the abdomen or flank (25%), weight loss (33%), fever (20%), high blood pressure (20%), night sweats and generally feeling unwell. When<unk>  metastasises, it most commonly spreads to the lymph nodes, lungs, liver, adrenal glands, brain or bones. Immunotherapy and targeted therapy have improved the outlook for metastatic<unk> .<unk>  is also associated with a number of paraneoplastic syndromes (PNS) which are conditions caused by either the hormones produced by the tumour or by the body's attack on the tumour and are present in about 20% of those with<unk> . These syndromes most commonly affect tissues which have not been invaded by the cancer. The most common PNSs seen in people with<unk>  are: high blood calcium levels, high red blood cell count, high platelet count and secondary amyloidosis.
Renal cell carcinoma
Renal medullary carcinoma
Renal oncocytoma
Papillary renal cell carcinoma
Renal anaplastic sarcoma
Renal medullary fibroma
Clear cell renal cell carcinoma
Clear cell papillary renal cell carcinoma