The immune system's role in the precise pathogenesis of<unk>  remains unclear. It appears that a certain type of immune cell (cytotoxic CD8+ T cell) is primarily responsible for keratinocyte death and subsequent skin detachment. Keratinocytes are the cells found lower in the epidermis and specialize in holding the surrounding skin cells together. It is theorized that CD8+ immune cells become overactive by stimulation from drugs or drug metabolites. CD8+ T cells then mediate keratinocyte cell death through release of a number of molecules, including perforin, granzyme B, and granulysin. Other agents, including tumor necrosis factor alpha and Fas ligand, also appear to be involved in<unk>  pathogenesis.
Toxic epidermal necrolysis
Staphylococcal scalded skin syndrome
Poikiloderma vasculare atrophicans
Chickenpox
Streptococcal intertrigo
Skin condition
Cutaneous lupus mucinosis
Staphylococcal infection