Some reviews have found a similar risk as hydrochlorothiazide, while other reviews found a higher risk of side effects. * Hypokalemia (low blood potassium) occurs occasionally; the risk of hypokalemia is higher in persons who are magnesium deficient * Hypomagnesemia (low blood magnesium) a review of four clinical trials found that low blood magnesium occurred in 20% of persons within a few weeks of beginning treatment with 50 mg of<unk>  daily. The risk of<unk> -associated hypomagnesemia is higher in persons with diabetes mellitus who have low dietary magnesium intake. * Hyponatremia (low blood sodium) occurred in 4.1% of subjects randomized to<unk>  in the Systolic Hypertension in the Elderly Trial, compared to 1.3% of control subjects. The risk of hyponatremia varies from 5 per 100,000 person-years for those younger than 40 years of age to 730 per 100,000 person-years in those older than 80 years of age. Hyponatremia is more likely in persons with certain genetic variants of the prostaglandin transporter SLCO2A1 associated with elevated urinary PGE2 and inappropriately low plasma ADH levels in the setting of low plasma osmolality. Thiazide-associated hyponatremia is often more severe than loop diuretic-associated hyponatremia because the predominant action of thiazides occurs late in the tubular flow, reducing opportunity to apply additional corrective action further along the tubule. * Hypercalcemia (high blood calcium level) can occur in normal persons exposed to<unk>  but is more likely to occur when persons with sub-clinical hyperparathyroidism are exposed to<unk> . * Hyperuricemia, high levels of uric acid in the blood * Hyperglycemia, high blood sugar is more common in persons who are magnesium deficient * Hyperlipidemia, high cholesterol and triglycerides * Headache * Nausea/vomiting * Photosensitivity increased susceptibility to sunburn of skin with sun exposure * Photoonycholysis detachment of nails from nailbed with sun exposure * Weight gain * Gout; approximately doubles the risk * Pancreatitis The frequency and severity of these adverse effects is much reduced when<unk>  is used at lower doses (e.g., 12.5 mg per day).
Chlortalidone
Primidone
Rimonabant
Thioridazine
Ziprasidone
Domperidone
Methylphenidate
Paliperidone