Clinical presentation is variable. First symptoms usually occur at birth but can take place in the first 6 months of life or in utero. Clinical Signs for GACI can include: *Decreased fetal activity *Gestation with an antenatal diagnosis of hydrops fetalis *Polyhydramnios *Pericardial effusion *Low biophysical profile *Marked cyanosis *Edema *Severe hypertension *Reduced or absent pulses *Refusal of feeds *Tachypnea *Vomiting *Abdominal distension *General<unk>  rigidity *Cardiac failure (most common clinical finding) *Strain pattern on electrocardiogram *Enlarged heart (cardiomegaly) *Echogenicity of the arteries and/or heart on imaging *High Blood Pressure (hypertension) *Respiratory distress *Blood vessel narrowing *Joint<unk> s *Hearing loss *Kidney failure *Gastrointestinal complications
Generalized arterial calcification of infancy
Primary familial brain calcification
Hypertension and brachydactyly syndrome
Multifocal fibrosclerosis
Calcinosis cutis
Lipodermatosclerosis
Normolipoproteinemic xanthomatosis
Universal angiomatosis