<unk>  frequently causes gastrointestinal distress with nausea and vomiting which can lead patients to stop taking it. This can sometimes be improved by taking it with food.<unk>  can cause hepatocellular toxicity and is contraindicated in patients with severe liver impairment. Patients on<unk>  should have regular monitoring of their liver function tests. Liver toxicity occurs in up to 5% of patients and follows a pattern similar to isoniazid, usually arising in the first 1 to 3 months of therapy, but can occur even after more than 6 months of therapy. The pattern of liver function test derangement is often a rise in the ALT and AST. Both central neurological side effects such as psychiatric disturbances and encephalopathy, along with peripheral neuropathy have been reported. Administering pyridoxine along with<unk>  may reduce these effects and is recommended.<unk>  is structurally similar to methimazole, which is used to inhibit thyroid hormone synthesis, and has been linked to hypothyroidism in several TB patients. Periodic monitoring of thyroid function while on<unk>  is recommended. Interactions<unk>  may worsen the adverse effects of other antituberculous drugs being taken at the same time. It boosts levels of isoniazid when taken together and can lead to increased rates of peripheral neuropathy and hepatotoxicity. When taken with cycloserine, seizures have been reported. High rates of hepatotoxicty have been reported when taken with rifampicin. The drug's labeling cautions against excessive alcohol ingestion as it may provoke a psychotic reaction.
Ethionamide
Dimethyllysergamide
Triparanol
Phenoxyethanol
Chloroxylenol
Iodixanol
Flonicamid
Phenethylamine