Similar to many general anesthetics, the exact mechanism of the action has not been clearly delineated.<unk>  reduces pain sensitivity (analgesia) and relaxes muscles.<unk>  likely binds to GABA, glutamate and glycine receptors, but has different effects on each receptor.<unk>  acts as a positive allosteric modulator of the GABAA receptor in electrophysiology studies of neurons and recombinant receptors. It potentiates glycine receptor activity, which decreases motor function. It inhibits receptor activity in the NMDA glutamate receptor subtypes.<unk>  inhibits conduction in activated potassium channels.<unk>  also affects intracellular molecules. It inhibits plasma membrane calcium ATPases (PMCAs) which affects membrane fluidity by hindering the flow of Ca2+ (calcium ions) out across the membrane, this in turn affects neuron depolarization. It binds to the D subunit of ATP synthase and NADH dehydrogenase. General anaesthesia with<unk>  reduces plasma endocannabinoid AEA concentrations, and this could be a consequence of stress reduction after loss of consciousness.
Isoflurane
Methoxyflurane
Desflurane
Halothane
Sevoflurane
Etomidate
Ketamine
Remifentanil