Serious adverse effects include gastrointestinal toxicity, hepatotoxicity, interstitial lung disease, prolonged QT syndrome, hyperglycemia, bradycardia, and pancreatitis. The most commonly reported side effects were diarrhea, nausea, elevated liver enzymes, vomiting, abdominal pain, fatigue, decreased appetite, and constipation. Due to the risk of elevated liver enzymes, it is recommended that liver function tests be performed every two weeks for the first 9 weeks of treatment.
Ceritinib
Axitinib
Abrocitinib
Sunitinib
Baricitinib
Erdafitinib
Upadacitinib
Dacomitinib