<unk>  refers to the absence of normal spleen function and is associated with some serious infection risks. Hyposplenism is used to describe reduced ('hypo-') splenic functioning, but not as severely affected as with<unk> m. Functional<unk>  occurs when splenic tissue is present but does not work well (e.g. sickle-cell disease, polysplenia) -such patients are managed as if<unk> -, while in anatomic<unk> , the spleen itself is absent.
Asplenia
Polysplenia
Hepatosplenomegaly
Pica 
Splenomegaly
Neutrophilia
Nipple pigmentation
Bisalbuminemia