<unk>  can be distinguished among other diseases by observing the density of a lymph follicle on low magnification. Lymph nodes with reactive follicles contain extensions outside its capsule, follicles present throughout the entire node, obvious centroblasts and the absence or diminishing mantle zones. Immunohistochemistry can help distinguish a difference between a patient with follicular lymphoma to<unk> . Reactive<unk>  does not express BCL2 proteins in B cell germinal centers and are absent light chain reaction in immunostaining and flow cytometry as well as absent IG rearrangements. Localized, or specific lymphadenopathies should be evaluated for etiologies that are associated with lymphatic drainage patterns. During a complete lymphatic physical examination, generalized lymphadenopathy may or may not be ruled out. BCL2 protein expression is usually absent in<unk>  but prominent in follicular lymphomas. A comparison with other stains that include germinal center markers such as BCL-6 or CD10 is useful to compare when determining a proper diagnosis. CD10 positive cells are metalloproteinase which activate or deactivate peptides through proteolytic cleavage. An official diagnosis of<unk>  might include imagining such as a PET scan and a tissue biopsy, depending on the clinical location and also the location of lymphadenopathy. A common blood panel test may help rule out other possible diagnosis, such as lymphomas based on the number of red, white and platelet cells found in the blood. If the patient has low blood cell counts, this can be an indication of lymphoma. Another indication of lymphoma compared to<unk>  is high levels of lactic dehydrogenase (LDH) and C-reactive proteins (CRP). A lymph node biopsy may reveal an official diagnosis for lymphoma, by ruling out<unk>  which can be determined by the rate of proliferation.
Follicular hyperplasia
Lymphoid hyperplasia
Perifollicular mucinosis
Microglandular hyperplasia
Hyperkeratinization
Pseudopolyps
Xanthogranulomatous inflammation
Reticular formation