<unk>  overdose symptoms vary widely due to the involvement of multiple organ systems. Some of the more overt overdose symptoms are listed in the table below. The number of instances of fatal<unk>  intoxication is low relative to its usage rates. In most fatalities,<unk>  was not the only drug involved. Acute toxicity is mainly caused by serotonin syndrome and sympathomimetic effects. Sympathomimetic side effects can be managed with carvedilol.<unk> 's toxicity in overdose may be exacerbated by caffeine, with which it is frequently cut in order to increase volume. A scheme for management of acute<unk>  toxicity has been published focusing on treatment of hyperthermia, hyponatraemia, serotonin syndrome, and multiple organ failure. + Symptoms of overdose System Minor or moderate overdose Severe overdose Cardiovascular * Disseminated intravascular coagulation * Intracranial hemorrhage * Severe hypertension or hypotension * Hypotensive bleeding Central nervoussystem * Hyperreflexia * Agitation * Mental confusion * Paranoia * Stimulant psychosis * Cognitive and memory impairment potentially to the point of retrograde or anterograde amnesia * Coma * Convulsions * Hallucinations * Loss of consciousness * Serotonin syndrome Musculoskeletal * Muscle rigidity * Rhabdomyolysis (i.e., rapid muscle breakdown) Respiratory * Acute respiratory distress syndrome Urinary * Acute kidney injury Other * Cerebral edema * Hepatitis * Hyperpyrexia (a life-threatening elevation of body temperature greater than or equal to ) * Hyponatremia (Syndrome of inappropriate antidiuretic hormone)
MDMA
Phencyclidine
Theobromine
Benzocaine
Heroin
Cocaine
Cocaine 
Amphetamine