The kernels of C.<unk>  contain<unk> n, a digoxin-type cardenolide and cardiac glycoside toxin that blocks the calcium ion channels in heart muscle, causing disruption of the heart beat, most often fatally. The most common symptom of toxicity in humans was noted to be vomiting. Electrocardiographic abnormalities were noted to be common, the most common being sinus bradycardia. Around half of the patients develop thrombocytopenia. Temporary cardiac pacing has been used in the management, apart from other supportive measures. The difficulty in detecting<unk> n in autopsies and the ability of strong spices to mask its taste makes it an agent of homicide and suicide in India; there were more than 500 cases of fatal<unk>  poisoning between 1989 and 1999 in the southwest Indian state of Kerala. A fatal dose of the poison is contained in one kernel, leading to death within 1–2 days. Common symptoms include: thumb *burning sensation in mouth *violent vomiting<unk> irregular respiration *headache *irregular heartbeat *coma and eventual death
Cerbera odollam
Hexamita
Gonyaulax
Arnica montana
Cynanchum viminale
Piedraia hortae
Hirudo orientalis
Brachyspira pilosicoli