Liver * Liver (liver ALP): * Cholestasis, cholecystitis, cholangitis, cirrhosis, primary biliary cholangitis, fatty liver, sarcoidosis, liver tumor, liver metastases, drug intoxication * Drugs: e.g. verapamil, carbamazepine, phenytoin, erythromycin, allopurinol, ranitidine, numerous antibiotics Bones * Bone disease (bone ALP): * Paget's disease, osteosarcoma, bone metastases of prostatic cancer (High / very high ALP values) * Other bone metastases * Renal osteodystrophy * Fractured bone * Skeletal involvement of other primary diseases: * Osteomalacia, rickets, vitamin D deficiency (moderate rise) * Malignant tumors (ALP originating from tumor) * Renal disease (secondary hyperparathyroidism) * Primary hyperthyroidism Other unlisted musculoskeletal conditions may also cause<unk> . Obesity<unk>  levels of the<unk><unk>  enzyme are reported among those who have obesity. A study reported there were higher serum levels of<unk><unk>  in obese than in the non-obese. With<unk>  levels, there is an increase in disproportionate intracellular fat depots and thereby releasing itself into the bloodstream. The relationship between<unk><unk>  and obesity is still being tested. Kidney<unk>  serum levels of<unk><unk>  has been associated with Chronic Kidney Disease (CKD). Studies have shown that<unk>  levels may predict mortality independent of bone metabolism factors and liver function tests in CKD.<unk>  levels are also associated with diabetes, hypertension, and cardiovascular disease; it was found that<unk>  levels are associated with<unk>  serum C-reactive protein (CRP), which could reflect an inflammatory and atherogenic milieu, possibly an alternative cause for<unk>  serum<unk><unk> . * Chronic kidney disease Cancer<unk>  in patients with cancer normally spans throughout the bones or liver. Metastases that exist in the lung, breast, prostate, colon, thyroid, and further organs can penetrate the liver or bone. Yet, cancers that are already present in certain organs and tissues can produce<unk><unk>  elevations if metastasis is not present. Isoenzymes, which are certain forms of<unk><unk>  generated by these tumors, enlarges the total volume of<unk><unk>  levels in experiential studies. The Regan isoenzyme is one of the best studies of these isoenzymes that is linked to several human cancers. Basically, the Regan isozenzyme is an<unk><unk>  that is located in the placenta and associated with gonadal and urologic cancers. * Breast carcinoma * Colon cancer * Leukemia – cancer of the bone marrow * Lymphoma – cancer of the white blood cells * Pancreatic cancer * Lung cancer
Elevated alkaline phosphatase
Elevated alpha-fetoprotein
Lymphocytic pleocytosis
Plasma cell dyscrasias
Elevated transaminases
Plasmacytosis
Pleocytosis
Villonodular synovitis