The cause is unknown but allergic and auto-inflammatory mechanisms have been proposed. In a 1957 review of IH, Mattingly did not find evidence that the condition is inherited unlike Reimann who, in 1974, describes the condition as “heritable, non-inflammatory, and afebrile”. More recently, specific association with the Mediterranean fever gene, MEFV, has been proposed. So, with some individuals carrying gene mutations (MEFV and also TRAPS-related genes), the native immune system seems to plays a role in the development of IH, i.e. there is an auto-immune component to the condition.
Intermittent hydrarthrosis
Neuralgia-inducing cavitational osteonecrosis
Complications of prolonged standing
Progressive osseous heteroplasia
Repetitive strain injury
Microdamage in bone
Articular cartilage damage
Metastatic calcification