+ Side effects of<unk>  at different doses in clinical trials Side effect Placebo<unk>  Duloxetine 5 mg/day 10 mg/day 15 mg/day 20 mg/day 60 mg/day Any 62% 66% 67% 70% 73% 77% Nausea 9% 21% 26% 32% 32% 36% Vomiting 1% 3% 5% 6% 6% 4% Diarrhea 6% 7% 7% 10% 7% ? Constipation 3% 3% 5% 6% 6% 10% Dry mouth 6% 7% 7% 6% 8% ? Flatulence 1% 1% 3% 2% 1% ? Dizziness 6% 6% 6% 8% 9% ? Abnormal dreams 1% <1% <1% 2% 3% ? Itching 1% 1% 2% 3% 3% ? Notes:<unk>  and duloxetine (an SNRI) were directly compared in randomized clinical trials. Other reported side effects of<unk>  in clinical trials included headache, nasal symptoms, somnolence, and excessive sweating. The most common side effects reported with<unk>  are nausea, vomiting, constipation, and sexual dysfunction, among others. With the exceptions of nausea and sexual dysfunction, these side effects were reported by less than or equal to 10% of study participants given<unk> . Significant percentages of placebo-treated participants also report these side effects. Discontinuation of treatment due to adverse effects in clinical trials was 8% with<unk>  versus 3% with placebo. Sexual dysfunction, such as decreased libido, abnormal orgasm, delayed ejaculation, and erectile dysfunction, are well-known side effects of SSRIs and serotonin–norepinephrine reuptake inhibitors (SNRIs). In clinical trials, sexual dysfunction occurred more often with<unk>  than with placebo and appeared to be dose-dependent. The specific incidences of treatment-emergent sexual dysfunction as measured with the Arizona Sexual Experience Scale (ASEX) were 14 to 20% for placebo and 16 to 34% for<unk>  over a dosage range of 5 to 20 mg/day. The incidence of sexual dysfunction with<unk>  was similar to that with the SNRI duloxetine, which had an incidence of 26 to 28% at the used dosage of 60 mg/day. However, treatment-emergent sexual dysfunction caused by a prior SSRI was better improved by switching to<unk>  than by switching to the SSRI escitalopram. In another study,<unk>  at a dosage of 10 mg/day though not at 20 mg/day produced less sexual dysfunction than the SSRI paroxetine. These findings suggest that although<unk>  can still cause sexual dysfunction itself, it may cause somewhat less sexual dysfunction than SSRIs and might be a useful alternative option for people experiencing sexual dysfunction with these medications. The rates of voluntarily or spontaneously reported sexual dysfunction with<unk>  are much lower than with the ASEX, ranging from <1 to 5% for<unk>  versus <1 to 2% for placebo in clinical trials. + Sexual dysfunction with<unk>  at different doses in clinical trials Quantification method Group Placebo<unk>  Duloxetine 5 mg/day 10 mg/day 15 mg/day 20 mg/day 60 mg/day Measured by Men 14% 16% 20% 19% 29% 26% Women 20% 22% 23% 33% 34% 28% Spontaneously reported Men 2% 3% 4% 4% 5% ? Women <1% <1% 1% <1% 2% ? Notes:<unk>  and duloxetine (an SNRI) were directly compared in randomized clinical trials. Significant changes in body weight (gain or loss) were not observed with<unk>  in clinical trials.<unk>  might cause less emotional blunting than SSRIs and SNRIs based on a couple of preliminary clinical studies. If<unk>  is used in combination with other serotonergic drugs like MAOIs or SSRIs, this may result in serotonin syndrome.
Vortioxetine
Atomoxetine
Edivoxetine
Dapoxetine
Duloxetine
Fluparoxan
Nabilone
Fluoxetine