Common *<unk>  increases the risk of genital fungal infections. The risk is highest in people with a prior history of genital fungal infections. * Urinary tract infections (UTIs) may be more common with<unk> . Certain individual clinical trials have demonstrated an increase risk but cumulative data across multiple trials show no increase in UTI risk. *<unk>  reduces systolic and diastolic blood pressure and can increase the risk of low blood pressure, which can cause fainting and/or falls. The risk is higher in older people, people taking diuretics, and people with reduced kidney function. * Slight increases in LDL cholesterol can be seen with<unk> , in the range of 2% to 4% from baseline. Serious * Diabetic ketoacidosis (DKA), a rare but potentially life-threatening condition, may occur more commonly with<unk>  and other SGLT-2 inhibitors. While DKA is usually associated with elevated blood glucose levels, in people taking SGLT-2 inhibitors DKA may be seen with uncharacteristically normal blood glucose levels, a phenomenon called euglycemic ketoacidosis. The absence of elevated blood glucose levels in people on an SGLT-2 inhibitor may make it more difficult to diagnose DKA. The risk of<unk> -associated DKA may be higher in the setting of illness, dehydration, surgery, and/or alcohol consumption. It is also seen in type 1 diabetes who take<unk> , which notably is an unapproved or "off-label" use of the medication. To lessen the risk of developing ketoacidosis (a serious condition in which the body produces high levels of blood acids called ketones) after surgery, the FDA has approved changes to the prescribing information for SGLT2 inhibitor diabetes medicines to recommend they be stopped temporarily before scheduled surgery.<unk>  should each be stopped at least three days before scheduled surgery. Symptoms of ketoacidosis include nausea, vomiting, abdominal pain, tiredness, and trouble breathing. * Fournier's gangrene, a rare but serious infection of the groin, occurs more commonly in people taking<unk>  and other SGLT-2 inhibitors. Symptoms include feverishness, a general sense of malaise, and pain or swelling around the genitals or in the skin behind them. The infection progresses quickly and urgent medical attention is recommended. *<unk>  can increase people' risk of low blood sugar when it is used together with a sulfonylurea or insulin. When used by itself or in addition to metformin it does not appear to increase the risk of hypoglycemia.
Empagliflozin
Canagliflozin
Linagliptin
Dapagliflozin
Sotagliflozin
Liraglutide
Vildagliptin
Pioglitazone