The anti-Purkinje cell antibodies originally described in<unk>  led to the hypothesis that the antibody might be pathogenic, much as earlier studies had demonstrated pathogenicity of anti-acetylcholine receptor antibodies in myasthenia gravis. However, when the antibody was used to clone the cDNA encoding the cdr2 antigen, it was found to be an intracellular protein. This led to the suggestion that there might be a cell-mediated component (T cell) in disease pathogenesis. cdr2 antigen-specific CD8+ T cells were subsequently described in more anti-Yo-positive<unk>  patients,. These T cells are likely components in both the anti-tumor immune response and in the neuronal<unk> .
Paraneoplastic cerebellar degeneration
Post viral cerebellar ataxia
Post-encephalitic parkinsonism
CMV polyradiculomyelopathy
Juvenile primary lateral sclerosis
Vascular myelopathy
Demyelinating disease
Malignant multiple sclerosis