<unk>  is a group of diseases in which abnormal proteins, known as amyloid fibrils, build up in tissue. There are several non-specific and vague signs and symptoms associated with<unk> . These include: fatigue, peripheral edema, weight loss, shortness of breath, palpitations, and feeling faint with standing. In<unk> <unk> , specific indicators can include enlargement of the tongue and periorbital purpura. In wild-type ATTR<unk> , non-cardiac symptoms include: bilateral carpal tunnel syndrome, lumbar spinal stenosis, bicep tendon rupture, small fiber neuropathy, and autonomic dysfunction. There are about 36 different types of<unk> , each due to a specific protein misfolding. Within these 36 proteins, 19 are grouped into localized forms, 14 are grouped as systemic forms, and 3 proteins can identify as either. These proteins can become irregular due to genetic effects, as well as through acquired environmental factors. The four most common types of systemic<unk>  are light chain <unk> , inflammation (AA), dialysis-related (Aβ2M), and hereditary and old age (ATTR and familial amyloid polyneuropathy). Diagnosis may be suspected when protein is found in the urine, organ enlargement is present, or problems are found with multiple peripheral nerves and it is unclear why. Diagnosis is confirmed by tissue biopsy. Due to the variable presentation, a diagnosis can often take some time to reach. Treatment is geared towards decreasing the amount of the involved protein. This may sometimes be achieved by determining and treating the underlying cause.<unk> <unk>  occurs in about 3–13 per million people per year and AA<unk>  in about 2 per million people per year. The usual age of onset of these two types is 55 to 60 years old. Without treatment, life expectancy is between six months and four years. In the developed world about 1 per 1,000 people die annually from<unk> .<unk>  has been described since at least 1639.
Amyloidosis
Sjögren syndrome  Sjögren syndrome  1
Gamasoidosis
Melioidosis
Sarcoidosis
Amyloid cardiomyopathy
Neurosarcoidosis
Cardiac amyloidosis