<unk>  is transported by the solute carrier proteins SLCO1B1 and SLCO1B3. Drugs that inhibit this proteins, such as rifampicin, ciclosporin, and a number of AIDS medications (atazanavir, darunavir, lopinavir, saquinavir, tipranavir, cobicistat), can cause a significant increase in<unk>  blood plasma levels. The substance is degraded by the liver enzyme CYP3A4. Combination with drugs that induce this enzyme, such as efavirenz, carbamazepine or St. John's wort, can lead to ineffectively low plasma levels of<unk> . Combination with CYP3A4 inhibitors may increase plasma levels.
Grazoprevir
Simeprevir
Glecaprevir
Narlaprevir
Saquinavir
Telaprevir
Fostemsavir
Ledipasvir