+ Age-standardized mortality rates from intrahepatic (IC) and extrahepatic (EC)<unk>  for men and women, by country Country IC (men/women) EC (men/women) U.S.A. 0.60/0.43 0.70/0.87 Japan 0.23/0.10 5.87/5.20 Australia 0.70/0.53 0.90/1.23 England/Wales 0.83/0.63 0.43/0.60 Scotland 1.17/1.00 0.60/0.73 France 0.27/0.20 1.20/1.37 Italy 0.13/0.13 2.10/2.60<unk>  is a relatively rare form of cancer; each year, approximately 2,000 to 3,000 new cases are diagnosed in the United States, translating into an annual incidence of 1–2 cases per 100,000 people. Autopsy series have reported a prevalence of 0.01% to 0.46%. There is a higher prevalence of<unk>  in Asia, which has been attributed to endemic chronic parasitic infestation. The incidence of<unk>  increases with age, and the disease is slightly more common in men than in women (possibly due to the higher rate of primary sclerosing cholangitis, a major risk factor, in men). The prevalence of<unk>  in people with primary sclerosing cholangitis may be as high as 30%, based on autopsy studies. Multiple studies have documented a steady increase in the incidence of intrahepatic<unk> ; increases have been seen in North America, Europe, Asia, and Australia. The reasons for the increasing occurrence of<unk>  are unclear; improved diagnostic methods may be partially responsible, but the prevalence of potential risk factors for<unk> , such as HIV infection, has also been increasing during this time frame. Liver tumor types by relative incidence in adults in the United States, with<unk>  at top right.
Cholangiocarcinoma
Hepatoid tumor
Cholangiosarcoma
Periampullary cancer
Pancreatoblastoma
Hepatocellular carcinoma
Echinococcosis
Hepatoblastoma