<unk>  can be detected through a complete blood count (CBC). The root cause of<unk>  can be determined through a bone marrow biopsy, genetic testing to look for genetic mutations, or ultrasound to determine enlargement of the spleen. A bone marrow aspirate may be utilized to confirm an increase in basophils or significantly high numbers of precursors to the granulocytes. Since<unk>  is present in a vast range of clinical conditions, depending on a variety of underlying causes, supplemental signs and symptoms must be investigated for a diagnosis. If splenomegaly is detected, a myeloproliferative syndrome may be suspected. Intrinsically related symptoms such as fever, malaise, pruritus (itching) due to the release of histamine, fatigue, and right upper quadrant pain may be present in the afflicted patient. With some conditions, such as polycythemia vera, erythromelalgia, or burning of the palms and soles, coupled with thrombocytosis is common. This severe symptomatology may require urgent attention. If<unk>  and the aforementioned symptoms are present with concurrent eosinophilia greater than 1500 cells/μL, hypereosinophilic syndrome may be considered. In cases of underlying allergic reactions or adverse sensitivity, skin rashes may be present. After symptomatic evaluation, a peripheral blood smear is examined in order to determine cell counts.In cases of a supposed myeloid neoplasm, a bone marrow biopsy will be performed utilizing cytogenetic analysis. This type of testing utilizes the karyotypes of chromosomes for each type of leukocyte and looks for a significant abnormality in any of the conventional karyotypes which could support the diagnosis of a neoplastic process.<unk>  on its own does not cause much complication other than those related to the primary causative condition. However, basophils can degranulate causing tissue damage, but this can be avoided with early detection and intervention.
Basophilia
Exophilia
Eosinophilia
Parosmia
Pseudothrombocytopenia
Basopenia
Polymelia
Hypodysfibrinogenemia