<unk> , or Custodiol<unk>  solution, is a high-flow, low-potassium preservation solution used for organ transplantation. The solution was initially developed by Hans-Jürgen Bretschneider.<unk>  solution is intended for perfusion and flushing of donor liver, kidney, heart, lung and pancreas prior to removal from the donor and for preserving these organs during hypothermic storage and transport to the recipient.<unk>  solution is based on the principle of inactivating organ function by withdrawal of extracellular sodium and calcium, together with intensive buffering of the extracellular space by means of histidine/histidine hydrochloride, so as to prolong the period during which the organs will tolerate interruption of oxygenated blood. The composition of<unk>  is similar to that of extracellular fluid. All of the components of<unk>  occur naturally in the body. The osmolarity of<unk>  is 310 mOsm/L.
Histidine-tryptophan-ketoglutarate
Uridine triacetate
Nicotinamide mononucleotide
Inositol
Nicotinamide
Cysteamine
3-Methylhistidine
Fructosamine