Long-term (prophylactic) regimens of oral<unk>  are absolutely contraindicated in people with advanced kidney failure (including those on dialysis). About 10-20% of a<unk>  dose is excreted unchanged by the kidneys; it is not removed by hemodialysis. Cumulative toxicity is a high probability in this clinical setting, and a severe neuromyopathy may result. The presentation includes a progressive onset of proximal weakness, elevated creatine kinase, and sensorimotor polyneuropathy.<unk>  toxicity can be potentiated by the concomitant use of cholesterol-lowering drugs.
Colchicine
Diclofenac
Ketoprofen
Aceclofenac
Meclofenamic acid
Allopurinol
Diclofenamide
Indoprofen