<unk>  can be primary (as a result of a genetic defect) or secondary to another disease process. Type I primary<unk>  (PH1) is associated mutations in the gene encoding AGXT, a key enzyme involved in oxalate metabolism. PH1 is an example of a protein mistargeting disease, wherein AGXT shows a trafficking defect. Instead of being trafficked to peroxisomes, it is targeted to mitochondria, where it is metabolically deficient despite being catalytically active. Type II is associated with GRHPR. Secondary<unk>  can occur as a complication of jejunoileal bypass, or in a patient who has lost much of the ileum with an intact colon. In these cases,<unk>  is caused by excessive gastrointestinal oxalate absorption. Excessive intake of oxalate-containing food, such as rhubarb, may also be a cause in rare cases.
Hyperoxaluria
Pentosuria
Sialuria
Cystinuria
Xanthinuria
Uricosuria
Hyperuricosuria
Aminoaciduria