Differential diagnosis During the first few weeks after birth, when the lesions are not very reticulated,<unk>  may look very similar to vascular lesions such as port-wine stains. However, during follow-up,<unk>  lesions become characteristic in their appearance. They must be differentiated from other causes of persistent reticulated vascular lesions, such as those in the following table: Diseases Characteristics Diffuse phlebectasia rare progressive harmartomatous malformation involving the deeper veins Livedo reticularis associated with collagen-vascular disease lace pattern of cyanotic skin discoloration secondary to dilation of subpapillary veinous plexi and occlusion of small vessels feeding the upper<unk>  Neonatal lupus erythematosus well-demarcated erythematous, mild-scaling plaque that is often annular and appears predominantly on the scalp, neck, or face Nevus anemicus<unk> l single patch manifested by skin pallor, most commonly seen on the trunk Nevus flammeus (port-wine stain) pale pink to red-purple, usually unilateral macules of the face or extremities Physiologic<unk><unk>  reticulated mottling appearance of the skin that physiologically responds to cold environments Primary antiphospholipid syndrome (APS) increased tendency to form venous and/or arterial thromboses, often accompanied by thrombocytopenia in the presence of the antiphospholipid antibodies Histology Some patients have a few or no histopathologic abnormalities. Histological examination of a biopsy may show an increase in the number and size of capillaries and veins (rarely lymphatics), dilated capillaries located in the deeper dermis, and hyperplasia and swollen endothelial cells with occasional dilated veins and venous lakes. Associated abnormalities Associated abnormalities include the following: * Body asymmetry (extremities; macrocephaly) * Glaucoma * Cutaneous atrophy * Neurological anomalies * Vascular anomalies (nevus flammeus /Sturge-Weber/Klippel-Trénauna Adams Oliver syndrome) * Psychomotor and/or mental retardation * Chronic ulceration that can complicate long-term<unk>  * Chronic urticaria.
Cutis marmorata telangiectatica congenita
Nevus comedonicus syndrome
Papular eruption of blacks
Prurigo simplex
Ichthyosis bullosa of Siemens
Prurigo nodularis
Nevus anemicus
Phakomatosis pigmentokeratotica