The symptoms produced by<unk>  vary by the location of the metastases. For instance: * Metastatic disease to the bone causes severe, progressive pain, and, less commonly, pathological fracture, erythema over the affected bone, and swelling. *<unk>  to the brain causes the following symptoms: persistent, progressively worsening headache, visual changes, seizures, nausea or vomiting, vertigo, behavioral and personality changes, and increased intracranial pressure. * Metastatic disease to the liver causes jaundice, elevated liver enzymes, abdominal pain, loss of appetite, nausea, and vomiting *<unk>  to the lung or pleura causes chronic cough, dyspnea, abnormal chest X-ray, and chest pain. * Other nonspecific systemic symptoms of<unk>  include fatigue, malaise, weight loss, and poor appetite. *Sometimes people with<unk>  do not have any notable changes or symptoms. Bone Roughly 70% of all patients living with advanced breast cancer have bone metastases Very often bone metastases can be successfully managed for a long time. Brain Brain metastasis is observed in 10% of breast cancer patients with metastatic properties Many of the breast cancer therapies (like targeted antibodies) fail to penetrate the blood–brain barrier, hence allowing for tumor recurrence in the central nervous system.
Metastatic breast cancer
Metastatic carcinoma
Cancer of unknown primary origin
Medullary carcinoma
Acinar cell carcinoma of the pancreas
Adrenocortical carcinoma
Hormone receptor positive breast tumor
Parathyroid carcinoma