Initial infection by the virus and primary spread of the virus causes the onset of non-specific symptoms such as headache and fever. Secondary spread and the multiplication of the virus in the CNS (central nervous system) causes symptoms such as stiff neck, lethargy and seizures. It then can result in<unk> , when inflammation of the brain, produced by infection by the virus, damages nerve cells, which affects signaling of the brain to the body. After the virus enters the body via a mosquito bite, the virus undergoes local replication at the skin site where virus entered the body. A primary spread of virus occurs, with seeding of the reticuloendothelial system, mainly in the liver, spleen, and lymph nodes. With the ongoing replication of the virus a secondary spread occurs, with the seeding of the CNS. Not all the cases reach this stage, depending on the efficiency of viral replication at the different stages and the degree of virus spread. The<unk><unk>  virus invades the CNS through either the cerebral capillary endothelial cells or the choroid plexus.
California encephalitis orthobunyavirus
Western equine encephalitis virus
Caño Delgadito orthohantavirus
Sepik virus
Dobrava-Belgrade orthohantavirus
Bayou orthohantavirus
Cricket paralysis virus
New York orthohantavirus