Homozygous Hb<unk>  Those homozygous (Hb<unk> Lepore; a very rare situation) or compound heterozygous (Hb<unk> -Β-thalassaemia) might suffer from a severe anaemia. They should be managed in a comprehensive multi-disciplinary program of care. Management includes a regular course of blood transfusions, although the clinical severity in compound (double) heterozygotes can range from minor to major, depending on the combination of genes that have caused the condition. Heterozygous Hb<unk>  Individuals heterozygous for the Hb<unk>  require no particular treatment. There is no anemia or, if there is, it is very mild.
Hemoglobin Lepore syndrome
Freeman–Sheldon syndrome
3-M syndrome
Sick cell syndrome
Beta thalassemia
Hughes–Stovin syndrome
Fryns-Aftimos syndrome
Diamond–Blackfan anemia