It was the first genetic disease treated with hematopoietic stem cell transplantation (osteoclasts are derived from hematopoietic precursors). There is no cure, although curative therapy with bone marrow transplantion is being investigated in clinical trials. It is believed the healthy marrow will provide the sufferer with cells from which osteoclasts will develop. If complications occur in children, patients can be treated with vitamin D. Gamma interferon has also been shown to be effective, and it can be associated to vitamin D. Erythropoetin has been used to treat any associated anemia. Corticosteroids may alleviate both the anemia and stimulate bone resorption. Fractures and osteomyelitis can be treated as usual. Treatment for<unk>  depends on the specific symptoms present and the severity in each person. Therefore, treatment<unk> tions must be evaluated on an individual basis. Nutritional support is important to improve growth and it also enhances responsiveness to other treatment<unk> tions. A calcium-deficient diet has been beneficial for some affected people. Treatment is necessary for the infantile form: * Vitamin D (calcitriol) appears to stimulate dormant osteoclasts, which stimulates bone resorption * Gamma interferon can have long-term benefits. It improves white blood cell function (leading to fewer infections), decreases bone volume, and increases bone marrow volume. * Erythropoietin can be used for anemia, and corticosteroids can be used for anemia and to stimulate bone resorption. Bone marrow transplantation (BMT) improves some cases of severe, infantile<unk>  associated with bone marrow failure, and offers the best chance of longer-term survival for individuals with this type. In pediatric (childhood)<unk> , surgery is sometimes needed because of fractures. Adult<unk>  typically does not require treatment, but complications of the condition may require intervention. Surgery may be needed for aesthetic or functional reasons (such as multiple fractures, deformity, and loss of function), or for severe degenerative joint disease.
Osteopetrosis
Avascular necrosis
Leri pleonosteosis
Osteochondrosis
Osteitis fibrosa cystica
Osteofibrous dysplasia
Osteoma
Osteopoikilosis