The<unk> <unk><unk>  or<unk><unk>  is a nucleic acid motif that functions as the protein translation initiation site in most eukaryotic mRNA transcripts. Regarded as the optimum<unk>  for initiating translation in eukaryotes, the<unk>  is an integral aspect of protein regulation and overall cellular health as well as having implications in human disease. It ensures that a protein is correctly translated from the genetic message, mediating ribosome assembly and translation initiation. A wrong start site can result in non-functional proteins. As it has become more studied, expansions of the nucleotide<unk> , bases of importance, and notable exceptions have arisen. The<unk>  was named after the scientist who discovered it, Marilyn<unk> .<unk>  discovered the<unk>  through a detailed analysis of DNA genomic<unk> s. The<unk><unk>  is not to be confused with the ribosomal binding site (RBS), that being either the 5′ cap of a messenger RNA or an internal ribosome entry site (IRES).
Kozak consensus sequence
Insertion sequence
Active chromatin sequence
Cis-regulatory element
Triage tag
WAIFW matrix
HA-tag
MSin3 interaction domain