In terms of the genetics of<unk>  11 of 18 known genes are caused by repeated expansions in corresponding proteins, sharing the same mutational mechanism. SCAs can be caused by conventional mutations or large rearrangements in genes that make glutamate and calcium signaling, channel function, tau regulation and mitochondrial activity or RNA alteration. The mechanism of Type I is not completely known, however, Whaley, et al. suggest the polyglutamine product is toxic to the cell at a protein level, this effect may be done by transcriptional dysregulation and disruption of calcium homeostasis which causes apoptosis to occur earlier.
Autosomal dominant cerebellar ataxia
Autosomal recessive cerebellar ataxia
Non-progressive congenital ataxia
Benign hereditary chorea
Spinal muscular atrophy with lower extremity predominance 1
Autosomal recessive cerebellar ataxia type 1
Tropical ataxic neuropathy
Spinocerebellar ataxia