The symptoms of<unk>  are similar to those of rheumatoid arthritis. Patients suffer from painful, stiff, and swollen joints, most commonly in the joints of the hands, feet, and arms. In some affected individuals,<unk>  may develop during a period when the symptoms and physical findings associated with rheumatoid arthritis have subsided or are not present; in this case,<unk>  may remain undiagnosed. In more rare instances, the development of<unk>  may precede the development of the symptoms and physical findings associated with rheumatoid arthritis.<unk>  is also characterized by an abnormally enlarged spleen (splenomegaly) and abnormally low levels of certain white blood cells (neutropenia). As a result of neutropenia, affected individuals are increasingly susceptible to certain infections. Keratoconjunctivitis sicca may occur due to secondary Sjögren's syndrome. Individuals with<unk>  may also experience fever, weight loss, and/or fatigue. In some cases, affected individuals may have discoloration (abnormal brown pigmentation) of the skin, particularly of the leg, sores (ulcers) on the lower leg, and/or an abnormally large liver (hepatomegaly). In addition, affected individuals may have abnormally low levels of circulating red blood cells (anemia), a decrease in circulating blood platelets that assist in blood clotting functions (thrombocytopenia), abnormal liver function tests and/or inflammation of the blood vessels (vasculitis). Complications * Recurrent infection * Enlargement of the spleen causing too few red blood cells and platelets in the bloodstream * Enlarged lymph nodes * Skin hyperpigmentation * Cutaneous ulceration
Felty's syndrome
SUNCT syndrome
Crome syndrome
Eosinophilia–myalgia syndrome
Michels Caskey syndrome
Roemheld syndrome
Mendelson's syndrome
MASA syndrome