<unk>  is an anthracycline drug used for chemotherapy. It can be used in combination with other medications to treat breast cancer in patients who have had surgery to remove the tumor. It is marketed by Pfizer under the trade name Ellence in the US and Pharmorubicin or<unk>  Ebewe elsewhere. Similarly to other anthracyclines,<unk>  acts by intercalating DNA strands. Intercalation results in complex formation which inhibits DNA and RNA synthesis. It also triggers DNA cleavage by topoisomerase II, resulting in mechanisms that lead to cell death. Binding to cell membranes and plasma proteins may be involved in the compound's cytotoxic effects.<unk>  also generates free radicals that cause cell and DNA damage.<unk>  is favoured over doxorubicin, the most popular anthracycline, in some chemotherapy regimens as it appears to cause fewer side-effects.<unk>  has a different spatial orientation of the hydroxyl group at the 4' carbon of the sugar - it has the opposite chirality - which may account for its faster elimination and reduced toxicity.<unk>  is primarily used against breast and ovarian cancer, gastric cancer, lung cancer and lymphomas.
Epirubicin
Valrubicin
Ifosfamide
Vincristine
Doxorubicin
Daunorubicin
Mitoxantrone
Etoposide