The predominant clinical symptoms of<unk>  are<unk> d and inelastic<unk>  over the face, backs of hands/fingers, tops of feet, and abdomen, delayed closure of the fontanel (baby’s soft spot), and increased palmar and plantar creases in the hands and feet, respectively. Patients may experience a wide variety of symptoms (see table). The assortment of symptoms displayed and symptom severity (particularly growth and developmental delays) vary from patient to patient. Symptom Additional Description Excessive<unk> d<unk>  Delayed Growth & Motor development Cognitive Impairment Hernias Musculoskeletal & Connective Tissue Abnormalities Hip dislocation, loose joints, scoliosis Broad Nasal Tip Microcephaly Small infant head size Short Stature Sub-average height Low-set Ears Smooth Philtrum Flat upper lip groove Hypertelorism Wide-set eye Infantile Muscular Hypotonia Low infant muscle tone Pectus Evacatum Caved-in chest High Myopia Severe near-sightedness Cryptorchidism Undescended testes Epicanthus Prominent Eye folds Deep Plantar and Palmar Crease Deep palm and sole of feet creases Dental Underdevelopment Small teeth, delayed eruption, high palate, cavities Nasally Speech Sparse Hair Reduced Hair Density Prominent Nasolabial Fold Deep smile lines Intrauterine Growth Retardation Very low fetal weight Down Slanted Palpebral Fissures Downward eye slant Osteoporosis Brittle, weak bones Layers of the<unk> .<unk>  affects both the papillary and reticular dermis. Microscopic analysis of epidermal samples of a four-month year old with<unk>  revealed an irregular pattern of elastic fiber distribution. Fewer elastic fibers are present in the papillary dermis and fragmented elastic fibers in the reticular dermis are observed. Epidermal samples from the same patient subjected to electron microscopy revealed that elastin fibers display abnormally high levels of fragmentation and clumping of microfibrils, with little amorphous elastin. Within collagen bundles, collagen fibrils are of irregular shape and thickness. These disruptions of the patient’s connective tissue play a role in the inelasticity of the<unk>  and<unk> ng.
Wrinkly skin syndrome
Peeling skin syndrome
Gradenigo's syndrome
Swimmer's itch
Heat urticaria
Pressure urticaria
Intertrigo
Sunburn