<unk>  is an animal carcinogen and is considered to be a probable human carcinogen. After its introduction as a fungicide in 1945, for crop seeds, this toxic chemical was found in all food types.<unk>  was banned from use in the United States in 1966. This material has been classified by the International Agency for Research on Cancer (IARC) as a Group 2B carcinogen (possibly carcinogenic to humans). Animal carcinogenicity data for<unk>  show increased incidences of liver, kidney (renal tubular tumours) and thyroid cancers. Chronic oral exposure in humans has been shown to give rise to a liver disease (porphyria cutanea tarda), skin lesions with discoloration, ulceration, photosensitivity, thyroid effects, bone effects and loss of hair. Neurological changes have been reported in rodents exposed to<unk> .<unk>  may cause embryolethality and teratogenic effects. Human and animal studies have demonstrated that<unk>  crosses the placenta to accumulate in foetal tissues and is transferred in breast milk.<unk>  is very toxic to aquatic organisms. It may cause long term adverse effects in the aquatic environment. Therefore, release into waterways should be avoided. It is persistent in the environment. Ecological investigations have found that biomagnification up the food chain does occur.<unk>  has a half life in the soil of between 3 and 6 years. Risk of bioaccumulation in an aquatic species is high. Toxicology * Oral LD50 (rat): 10,000 mg/kg * Oral LD50 (mice): 4,000 mg/kg * Inhalation LC50 (rat): 3600 mg/m3 Material has relatively low acute toxicity but is toxic because of its persistent and cumulative nature in body tissues in rich lipid content. Unique Exposure Incident In Anatolia, Turkey between 1955 and 1959, during a period when bread wheat was unavailable, 500 people were fatally poisoned and more than 4,000 people fell ill by eating bread made with<unk> -treated seed that was intended for agriculture use. Most of the sick were affected with a liver condition called porphyria cutanea tarda, which disturbs the metabolism of hemoglobin and results in skin lesions. Almost all breastfeeding children under the age of two, whose mothers had eaten tainted bread, died from a condition called "pembe yara" or "pink sore", most likely from high doses of<unk>  in the breast milk. In one mother's breast milk the<unk>  level was found to be 20 parts per million in lipid, approximately 2,000 times the average levels of contamination found in breast-milk samples around the world. Follow-up studies 20 to 30 years after the poisoning found average<unk>  levels in breast milk were still more than seven times the average for unexposed women in that part of the world (56 specimens of human milk obtained from mothers with porphyria, average value was 0.51 ppm in<unk> -exposed patients compared to 0.07 ppm in unexposed controls), and 150 times the level allowed in cow's milk. In the same follow-up study of 252 patients (162 males and 90 females, avg. current age of 35.7 years), 20–30 years' postexposure, many subjects had dermatologic, neurologic, and orthopedic symptoms and signs. The observed clinical findings include scarring of the face and hands (83.7%), hyperpigmentation (65%), hypertrichosis (44.8%), pinched faces (40.1%), painless arthritis (70.2%), small hands (66.6%), sensory shading (60.6%), myotonia (37.9%), cogwheeling (41.9%), enlarged thyroid (34.9%), and enlarged liver (4.8%). Urine and stool porphyrin levels were determined in all patients, and 17 have at least one of the porphyrins elevated. Offspring of mothers with three decades of<unk> -induced porphyria appear normal.
Hexachlorobenzene
Coal tar
Vinyl chloride
Benzene
Polychlorinated biphenyl
Naphthalene
Polychlorinated naphthalene
Nitrobenzene