<unk>  is a HECT domain E3 ubiquitin ligase that is ablated in non-agouti-lethal 18H (aka<unk> y) mice.<unk> y mice develop a severe immunological phenotype after birth that includes hyperplasia of lymphoid and hematopoietic cells, and stomach and lung inflammation. In humans<unk>  deficiency causes altered physical growth, craniofacial morphology defects, defective muscle development, and aberrant immune system function.<unk>  contains a C2 domain, proline-rich region, WW domains, HECT domain, and multiple amino acids that are phosphorylated and ubiquitinated.
ITCH
SFHAM
ROHHAD
EQUIL2
KHAT
SCAR
PATH 
IOMAI