Absorption The bioavailability of<unk>  is decreased when administered orally compared to an equivalent IV bolus dose. Use of oral<unk>  following a high-fat breakfast increases the mean peak drug levels by about 22%; however, the manufacturer does not make any specific meal recommendations. In addition, the use of antacids does not show pharmacokinetic interactions. Distribution The mean volume of distribution of<unk>  is approximately 10L. It is highly protein-bound, mainly to albumin. Metabolism<unk>  is extensively metabolized in the liver by the enzymes CYP2C9 and CYP3A4 (minor) into four inactive metabolites. Peroxidase activity is thought to be responsible for the other two remaining metabolites. Excretion<unk>  is predominantly excreted in the form of metabolites and occurs to equal extents in the urine and feces. Traces of unchanged parent drug are found in urine and feces. The mean elimination half-life ranges from 15 to 20 hours.
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