Oral manifestations of systematic<unk>  are signs and symptoms of<unk>  occurring elsewhere in the body detected in the oral cavity and oral secretions. High blood sugar can be detected by sampling saliva. Saliva sampling may be a non-invasive way to detect changes in the gut microbiome and changes in<unk><unk> . Another example is tertiary syphilis, where changes to teeth can occur. Syphilis infection can be associated with longitudinal furrows of the tongue. Mineral and vitamin deficiencies can cause the tongue to appear beefy red and feel sore. Those deficiencies are iron, folate, and vitamin B12. A hairy tongue may be an indication of Epstein Barr virus infection and is usually seen in those infected with human immunodeficiency virus. Other<unk><unk> s that can cause the tongue to form aphthous ulcers are: Crohn's<unk>  and ulcerative colitis, Behcet's Syndrome, pemphigus vulgaris, herpes simplex, histoplasmosis, and reactive arthritis.
Oral manifestations of systemic disease
Cutaneous perforating disorders
Skin manifestations of sarcoidosis
Congenital malformations of the dermatoglyphs
Chronic mucocutaneous candidiasis
Oral florid papillomatosis
Persistent edema of rosacea
Precancerous condition