The fifth<unk>  of hyper-IgM syndrome has been characterized in three patients from France and Japan. The symptoms are similar to hyper IgM syndrome<unk>  2, but the AICDA gene is intact. These three patients instead had mutations in the catalytic domain of uracil-DNA glycosylase, an enzyme that removes uracil from DNA. In hyper-IgM syndromes, patients are deficient in the immunoglobulins, IgG, IgE and IgA<unk> s since the antibody producing B cells can not carry out the gene recombination steps necessary to class switch from immunoglobulin M (IgM) to the other three immunoglobulins<unk> s.
Hyper-IgM syndrome type 5
Hyper-IgM syndrome type 2
Hyper-IgM syndrome type 1
Hyper-IgM syndrome type 3
Hyper-IgM syndrome type 4
Hyper IgM syndrome
Wiskott–Aldrich syndrome
Anti-IgLON5 disease