In 1998, a gene was found to be associated with the mutation. On chromosome 19, the gene known as STK11 (LKB1) is a possible tumor suppressor gene. It is inherited in an autosomal dominant pattern, which means that anyone who has PJS has a 50% chance of passing the disease on to their offspring.<unk>  is rare and studies typically include only a small number of patients. Even in those few studies that do contain a large number of patients, the quality of the evidence is limited due to pooling patients from many centers, selection bias (only patients with health problems coming from treatment are included), and historical bias (the patients reported are from a time before advances in the diagnosis of treatment of<unk>  were made). Probably due to this limited evidence base, cancer risk estimates for<unk>  vary from study to study. There is an estimated 18–21% risk of ovarian cancer, 9% risk of endometrial cancer, and 10% risk of cervical cancer, specifically adenoma malignum.
Peutz–Jeghers syndrome
Juvenile polyp
Familial adenomatous polyposis
Nijmegen breakage syndrome
MUTYH-associated polyposis
Juvenile polyposis syndrome
Serrated polyposis syndrome
Li–Fraumeni syndrome