Cysteinyl<unk> s<unk> C4,<unk> D4,<unk> E4 and<unk> F4 are often called cysteinyl<unk> s due to the presence of the amino acid cysteine in their structure. The cysteinyl<unk> s make up the slow-reacting substance of anaphylaxis (SRS-A).<unk> F4, like<unk> D4, is a metabolite of<unk> C4, but, unlike<unk> D4, which lacks the glutamic residue of glutathione,<unk> F4 lacks the glycine residue of glutathione.<unk> B4<unk> B4 is synthesized in vivo from<unk> A4 by the enzyme<unk> A4 hydrolase. Its primary function is to recruit neutrophils to areas of tissue damage, though it also helps promote the production of inflammatory cytokines by various immune cells. Drugs that block the actions of<unk> B4 have shown some efficacy in slowing the progression of neutrophil-mediated diseases.<unk> G4 There has also been postulated the existence of<unk> G4, a metabolite of<unk> E4 in which the cysteinyl moiety has been oxidized to an alpha-keto-acid (i.e.—the cysteine has been replaced by a pyruvate). Very little is known about this putative<unk> .<unk> B5<unk> s originating from the omega-3 class eicosapentanoic acid (EPA) have diminished inflammatory effects.<unk> B5 induces aggregation of rat neutrophils, chemokinesis of human polymorphonuclear neutrophils (PMN), lysosomal enzyme release from human PMN and potentiation of bradykinin-induced plasma exudation, although compared to<unk> B4, it has at least 30 times less potency.
Leukotriene
Antileukotriene
Tocotrienol
Histamine
Nitric oxide
Interleukin
Prostaglandin
Allethrins