Most patients with<unk><unk>  polyps (FGPs) do not have any symptoms, and the diagnosis is made on gastroscopy done for other reasons. Retrospective analysis of patients with sporadic FGPs shows that a high percentage do have symptoms, but that this is more likely to be related to the underlying disease responsible for the<unk> . These symptoms include: * epigastric pain * nausea * vomiting * weight loss The polyps on endoscopy are usually tiny, numerous and sessile, and usually scattered throughout the fundus of the stomach, where parietal cells are more numerous. They have the same colour as the gastric mucosa, and never have a stalk. When the polyps are biopsied, the pathology typically shows shortened gastric pits, and both superficial and deep cystic lesions in the<unk><unk> s, lined by all three types of cells of acid-producing mucosa: mucous, parietal and chief cells. As sometimes parietal cell hyperplasia may develop deep dilations of<unk> , one should be really strict in the diagnosis of FGPs (i.e. the presence of deep and superficial dilations). Infrequently, the two lesions may coexist. Foci of dysplasia can sometimes be seen. Disease associations FGPs can be found in association with the following genetic conditions: * * attenuated familial adenomatous<unk>  syndromes * Zollinger-Ellison syndrome * gastric adenocarcinoma associated with proxymal<unk>  of the stomach (GAPPS): this condition, described in three families is characterized by development of antral adenomas and FGPs, with early development of severe dysplasia and gastric cancer, in absence of overt intestinal<unk> . This condition has been recently characterized by a point mutation in exon 1B of APC gene. Sporadic FGPs have been associated with: * chronic use of proton pump inhibitors (proposed by some authors, denied by others) * Helicobacter pylori infection: there is a reverse relationship between infection and<unk><unk>  polyps, and infection by H pylori causes polyps regression.
Fundic gland polyposis
Macular corneal dystrophy
Congenital cataract
Corneal dystrophy
Ocular melanosis
Otosclerosis
Subepithelial mucinous corneal dystrophy
Vitreous bulge