<unk> , often abbreviated as<unk> , also known as<unk>  sexual precocity or gonadotropin-independent testotoxicosis, is a form of gonadotropin-independent<unk><unk>  in which boys experience early onset and progression of<unk> . Signs of<unk>  can develop as early as an age of 1 year. The spinal length in boys may be short due to a rapid advance in epiphyseal maturation. It is an autosomal dominant condition with a mutation of the luteinizing hormone (LH) receptor. As<unk>  is a gonadotropin-independent form of<unk><unk> , gonadotropin-releasing hormone agonists (GnRH agonists) are ineffective. Treatment is with drugs that suppress or block the effects of gonadal steroidogenesis, such as cyproterone acetate, ketoconazole, spironolactone, and testolactone. Alternatively, the combination of the androgen receptor antagonist bicalutamide and the aromatase inhibitor anastrozole may be used.
Familial male-limited precocious puberty
Mild androgen insensitivity syndrome
Persistent adrenarche syndrome
Androgen insensitivity syndrome
Aromatase excess syndrome
Partial androgen insensitivity syndrome
Late onset congenital adrenal hyperplasia
Klinefelter syndrome