Variations in the RET proto-oncogene cause<unk> . In recent decades no case of<unk>  has been reported that lacks such a variation. The M918T variant alone is responsible for approximately 95% of cases. All DNA variants that cause<unk>  are thought to enhance signaling through the RET protein, which is a receptor molecule found on cell membranes, whose ligands are part of the transforming growth factor beta signaling system. About half of cases are inherited from a parent as an autosomal dominant trait. The other half appear to be spontaneous mutations, usually arising in the paternal allele, particularly from older fathers. The sex ratio in de novo cases is also uneven: sons are twice as likely to develop<unk>  as daughters.
Multiple endocrine neoplasia type 2B
Multiple endocrine neoplasia type 1
Autoimmune polyendocrine syndrome type 1
Autoimmune polyendocrine syndrome type 2
Autoimmune polyendocrine syndrome type 3
McCune–Albright syndrome
Late onset congenital adrenal hyperplasia
Primary pigmented nodular adrenocortical disease