<unk>  belongs to a class of neurodegenerative diseases involving the aggregation of tau protein into neurofibrillary or gliofibrillary tangles (Neurofibrillary tangle) in the human brain. Tangles are formed by hyperphosphorylation of the microtubule protein known as tau, causing the protein to dissociate from microtubules and form insoluble aggregates. (These aggregations are also called paired helical filaments.) The mechanism of tangle formation is not well understood, and whether tangles are a primary cause of Alzheimer's disease or play a peripheral role is unknown.
Tauopathy
Synucleinopathy
Synaptopathy
Central core disease
Lewy body dementias
CADASIL
Corticobasal degeneration
Leukodystrophy