<unk>  <unk>  or Mesial temporal<unk>  (MTS) is a neuropathological condition with severe neuronal cell loss and gliosis in the hippocampus, specifically in the CA-1 (Cornu Ammonis area 1) and subiculum of the hippocampus. It was first described in 1880 by Wilhelm Sommer.<unk>  is a frequent pathologic finding in community-based dementia.<unk>  can be detected with autopsy or MRI. In MRI, a decrease in signal is observed at T1 and an increase in signal at T2. Positron emission tomography is also used as an aid for diagnosis. In PET examination, glucose uptake is lower than in the normal part. The reason for this is that the sclerotic part works at a lower level than the normal part and needs less energy. Individuals with<unk>  have similar initial symptoms and rates of dementia progression to those with Alzheimer's disease (AD) and therefore are frequently misclassified as having Alzheimer's Disease. But clinical and pathologic findings suggest that<unk>  has characteristics of a progressive disorder although the underlying cause remains elusive. A diagnosis of<unk>  has a significant effect on the life of patients because of the notable mortality, morbidity and social impact related to epilepsy, as well as side effects associated with antiepileptic treatments. Findings indicate that there is a strong genetic connection in the development of mesial temporal<unk> .Mesial temporal<unk>  used to be most commonly found as a single lesion in the brains of chronic epileptics who died a natural death which was estimated to be developed as a result of continued febrile convulsions.
Hippocampal sclerosis
Posterior cortical atrophy
Geographic atrophy
Superficial siderosis
Bilateral frontoparietal polymicrogyria
Cerebral atrophy
Neurofibrillary tangle
Corticobasal degeneration