<unk>  vaccine has been widely used since the second half of the 20th century. The first vaccines were whole-cell vaccines, composed of chemically inactivated bacteria. They are being replaced by acellular vaccines, composed of purified surface antigens, mainly fimbriae, filamentous haemaglutinin, pertactin and<unk>  toxin. It is part of the diphtheria, tetanus, and acellular<unk>  (DTaP) immunization.
Bordetella pertussis
Haemophilus influenzae
Bacillus anthracis
Rhodococcus equi
Mycoplasma pneumonia
Neisseria meningitidis
Legionella
Bordetella bronchiseptica