Genetic associations Type OMIM Gene Locus POF1 FMR1 Xq26-q28 POF2A DIAPH2 Xq13.3-q21.1 POF2B POF1B Xq13.3-q21.1 POF3 FOXL2 3q23 POF4 BMP15 Xp11.2 POF5 NOBOX 7q35 POF6 FIGLA 2p12 POF7 NR5A1 9q33 The cause of<unk>  is idiopathic in 90% of cases. Some cases of<unk>  are attributed to autoimmune disorders, genetic disorders such as Turner syndrome and Fragile X syndrome, metabolic defects, and enzyme defects. One study showed a strong correlation between incidence of<unk>  and certain<unk> ts in the inhibin alpha gene. Chemotherapy and radiation treatments for cancer can sometimes cause<unk> . The effect of chemotherapy or radiation is variable and in a mouse model, with results consistent with observations in humans, cyclophosphamide can result in an 87% reduction in primordial follicles 72 hours after administration. Women who have had a hysterectomy tend to go through menopause early and have a nearly twofold increased risk of<unk> . Almost any pelvic surgery has the potential to damage the ovary by affecting its blood supply or causing inflammation in the area resulting in<unk> . Galactosemia Woman patients who suffer from inherited classic galactosemia (galactose intolerance) may develop<unk> .
Primary ovarian insufficiency
Functional hypothalamic amenorrhea
Gonadotropin-resistant ovary syndrome
Androgen insufficiency syndrome
Hypergonadotropic hypergonadism
Polycystic ovary syndrome
Anovulation
Lactational amenorrhea