Around 1 in 50 people are affected by a known single-gene<unk> , while around 1 in 263 are affected by a chromosomal<unk> . Around 65% of people have some kind of health problem as a result of congenital<unk>  mutations. Due to the significantly large number of<unk> s, approximately 1 in 21 people are affected by a<unk>  classified as "rare" (usually defined as affecting less than 1 in 2,000 people). Most<unk> s are rare in themselves. There are well over 6,000 known<unk> s, and new<unk> s are constantly being described in medical literature.
Genetic disorder
Degenerative disease
Autoimmune disease
Metabolic disorder
Viral disease
Vascular anomaly
Immune disorder
Neurodegenerative disease