In biochemical studies of mitochondria, the effect of<unk>  on the ADP/ATP transport was recognized even before the actual transporter was identified.<unk>  or CATR bind to the ADP/ATP translocase, which is located on the inner mitochondrial membrane.<unk>  binds competitively to the translocase competitive up to a concentration of 5 mmol while CATR binds in a non-competitive manner. As a result, the exchange of ADP and ATP is no longer carried out and the cell dies due to lack of energy. The chemical structure and charge distribution of<unk>  is similar to that of ADP: the sulfate groups correspond to the phosphate groups, the glucose part corresponds to the ribose part, and the hydrophobic<unk> actyligenine residue corresponds to the hydrophobic purine residue of ADP. The carboxyl group on the C4 atom of the<unk> actyligenin is important for toxicity. If this is reduced to a hydroxyl group <unk> actylitriol), the substance becomes non-toxic. Modification of any of the sulfate groups renders the compound non-toxic. On the other hand, the free hydroxy group on the C6 atom of the glucose moiety can be modified without loss of compound potency.
Atractyloside
Ginkgo biloba
Diacerein
Beta-Zearalenol
Alpha-Zearalenol
Tienilic acid
Ellagic acid
Glycyrrhizin