According to the World Health Organization "Evidence suggests that<unk>  is the result of a genetically determined abnormal inflammatory reaction to mineral particles in irritant red clay soils derived from volcanic deposits". The pathophysiology of<unk>  is a combination of genetic susceptibility, possibly through associations with HLA-DQA1, HLA-DQB1, and HLA-DRB1 variants, and a cumulative exposure to irritant soil. In susceptible individuals, irritant soil particles penetrate the feet and collect in lymphatic vessels. Over time, chronic inflammation within the lymphatic vessels leads to fibrosis and occlusion.
Podoconiosis
Silica granuloma
Beryllium granuloma
Pasteurellosis
Spongiosis
Pulmonary talcosis
Contact granuloma
Silicone granuloma