The acronym "MASA" stands for the four main signs and symptoms associated with the<unk> : (1) mental retardation (mild to moderate intellectual disability), (2) aphasia (delayed onset of speech), (3) shuffling gait, and (4) adducted thumbs characterized by cleft palate, microcephaly, and dysmyelination. Affected males may also have a variable dilatation (widening) of the third heart ventricle.<unk>  has five other factors including hydrocephalus. The build-up is often caused by an obstruction that prevents proper fluid drainage. Spasticity of the lower limbs, causing the muscles to stiffen or tighten, preventing normal fluid movement. Aphasia, which is when someone loses the ability to understand or express speech, due to brain damage. Seizures, an abrupt, uncontrolled disturbance in the brain. Lastly, agenesis of the corpus callosum, a rare congenital disorder. It is characterized by a partial or complete absence (agenesis) of an area of the brain that connects the two cerebral hemispheres.
MASA syndrome
SUNCT syndrome
TAN syndrome
SAHA syndrome
Crome syndrome
Bogart–Bacall syndrome
Njølstad syndrome
TEMPI syndrome