This autoimmunity called<unk>  is an attack from the body's own immune system against the body's own tissues and organs. Early age onset of this disease in males causes severe enlargement of the secondary lymphoid organs, and insulin dependent diabetes This condition indicates the loss of CD4+ CD25+ T regulatory cells, and express the transcription factor Foxp3. Foxp3 decrease is a consequence of unchecked T cell activation, which is secondary to loss of regulatory T cells. Causes of death include haemorrhage, sepsis, Intractable diarrhoea and diabetic complications
IPEX syndrome
EAST syndrome
TAN syndrome
TEMPI syndrome
SUNCT syndrome
VEXAS syndrome
3C syndrome
RIDDLE syndrome