<unk> , sold under the brand names Prilosec and Losec, among others, is a medication used in the treatment of gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger–Ellison syndrome. It is also used to prevent upper gastrointestinal bleeding in people who are at high risk.<unk>  is a proton-pump inhibitor (PPI) and its effectiveness is similar to other PPIs. It can be taken by mouth or by injection into a vein. Common side effects include nausea, vomiting, headaches, abdominal pain, and increased intestinal gas. Serious side effects may include Clostridium difficile colitis, an increased risk of pneumonia, an increased risk of bone fractures, and the potential of masking stomach cancer. It is unclear if it is safe for use in pregnancy. It works by blocking the release of stomach acid.<unk>  was patented in 1978, and approved for medical use in 1988. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. In 2019, it was the eighth most commonly prescribed medication in the United States, with more than 52 million prescriptions. It is also available without a prescription in the United States.
Omeprazole
Rabeprazole
Esomeprazole
Lansoprazole
Dexlansoprazole
Tenatoprazole
Pantoprazole
Ranitidine