United States one-cent coin (size 19.05 mm/0.75 in) Depression In the United States,<unk>  is approved to treat major depressive disorder.<unk>  appears to have comparable efficacy and superior tolerability relative to other antidepressants. In the National Institute for Health and Clinical Excellence ranking of ten antidepressants for efficacy and cost-effectiveness,<unk>  is fifth in effectiveness (after mirtazapine, escitalopram, venlafaxine, and sertraline) and fourth in cost-effectiveness. The ranking results were based on a 2009 meta-analysis by Andrea Cipriani; an update of the analysis in 2018 produced broadly similar results. Evidence for effectiveness of<unk>  for treating depression in children is uncertain. Panic disorder<unk>  is licensed in the UK and other European countries for panic disorder, with or without agoraphobia. Other<unk>  may be used off-label to treat anxiety, and dysthymia, premenstrual dysphoric disorder, body dysmorphic disorder, and obsessive–compulsive disorder. It appears to be as effective as fluvoxamine and paroxetine in obsessive–compulsive disorder. Some data suggest the effectiveness of intravenous infusion of<unk>  in resistant OCD.<unk>  is well tolerated and as effective as moclobemide in social anxiety disorder. There are studies suggesting that<unk>  can be useful in reducing aggressive and impulsive behavior. It appears to be superior to placebo for behavioural disturbances associated with dementia. It has also been used successfully for hypersexuality in early Alzheimer's disease. A meta-analysis, including studies with fluoxetine, paroxetine, sertraline, escitalopram, and<unk>  versus placebo, showed SSRIs to be effective in reducing symptoms of premenstrual syndrome, whether taken continuously or just in the luteal phase. For alcoholism,<unk>  has produced a modest reduction in alcoholic drink intake and increase in drink-free days in studies of alcoholics, possibly by decreasing desire or reducing the reward. While on its own<unk>  is less effective than amitriptyline in the prevention of migraines, in refractory cases, combination therapy may be more effective.<unk>  and other SSRIs can be used to treat hot flashes. A 2009 multisite randomized controlled study found no benefit and some adverse effects in autistic children from<unk> , raising doubts whether SSRIs are effective for treating repetitive behavior in children with autism. Some research suggests<unk>  interacts with cannabinoid protein-couplings in the rat brain, and this is put forward as a potential cause of some of the drug's antidepressant effect. Administration<unk>  is typically taken in one dose, either in the morning or evening. It can be taken with or without food. Its absorption does not increase when taken with food, but doing so can help prevent nausea. Nausea is often caused when the 5HT3 receptors actively absorb free serotonin, as this receptor is present within the digestive tract. The 5HT3 receptors stimulate vomiting. This side effect, if present, should subside as the body adjusts to the medication.<unk>  is considered safe and well tolerated in the therapeutic dose range. Distinct from some other agents in its class, it exhibits linear pharmacokinetics and minimal drug interaction potential, making it a better choice for the elderly or comorbid patients.
Citalopram
Escitalopram
Atomoxetine
Sertraline
Dapoxetine
Duloxetine
Fluoxetine
Desipramine