Differentiated<unk>  granules by light microscopy) and poorly differentiated cases; Majority are poorly differentiated. MPO negative by light microscopy; granules positive in a speckled pattern by electron microscopy. Myeloid antigens are expressed. Diagnosis of poorly differentiated cases made by electron microscopy. May manifest basophil and mast cell granules by EM. Cytogenetically heterogeneous but frequently associated with Philadelphia chromosome. There is no clinically distinguishing features but may be more common in children and young adults and carry a poor prognosis.
Acute basophilic leukemia
Acute eosinophilic leukemia
Leukemoid reaction
Chronic eosinophilic leukemia
Mast cell leukemia
Hemophagocytic lymphohistiocytosis
Diffuse infiltrative lymphocytosis syndrome
Large granular lymphocytic leukemia