Platelets collected by using<unk>  at an American Red Cross donation center ASFA categories In 2010, the American Society for<unk>  published the 5th Special Edition(1) of evidence based guidelines for the practice of<unk>  Medicine. These guidelines are based upon a systematic review of available scientific literature. Clinical utility for a given disease is denoted by assignment of an ASFA Category (I – IV). The quality and strength of evidence are denoted by standard GRADE recommendations. ASFA Categories are defined as follows: * Category I for disorders where therapeutic<unk>  is accepted as a first line treatment, * Category II for disorders where therapeutic<unk>  is accepted as a second-line treatment, * Category III for disorders where the optimal role of therapeutic<unk>  is not clearly established and * Category IV for disorders where therapeutic<unk>  is considered ineffective or harmful. Diseases and disorders Only diseases (or mentioned special conditions thereof) with ASFA category I or II are displayed in bold, with category I being underlined in addition. Disease Special condition Type of<unk>  ASFAcategory ABO-incompatible hematopoietic stem cell transplantation Plasmapheresis II ABO-incompatible solid organ transplantation Kidney Plasmapheresis II Heart (Acute inflammatory demyelinating polyneuropathy Plasmapheresis I Acute liver failure Plasmapheresis III Age-related macular degeneration (AMD) Dry AMD Rheopheresis III Systemic amyloidosis Plasmapheresis IV Amyotrophic lateral sclerosis Plasmapheresis IV Anti-neutrophil cytoplasmic antibody-associated rapidly progressive glomerulonephritis Dialysis dependence Plasmapheresis I Diffuse alveolar pulmonary hemorrhage (DAH) I Dialysis independence III Goodpasture syndrome Dialysis independence Plasmapheresis I Diffuse alveolar hemorrhage (DAH) I Dialysis dependence and no DAH III Aplastic anemia or pure red cell aplasia Aplastic anemia Plasmapheresis III Pure red cell aplasia II Autoimmune hemolytic anemia Warm antibody autoimmune hemolytic anemia Plasmapheresis III Cold agglutinin disease, life-threatening II Babesiosis Severe Erythrocytapheresis I High-risk population II Burn with circulatory shock Plasmapheresis IV Heart transplant with allograft Prophylaxis of rejection Photopheresis I Treatment of rejection II Treatment of antibody-mediated rejection Plasmapheresis I Catastrophic antiphospholipid syndrome Plasmapheresis I Rasmussen's encephalitis Plasmapheresis or immunoadsorption II Chronic inflammatory demyelinating polyneuropathy Plasmapheresis I Coagulation factor inhibitors Immunoadsorption III Plasmapheresis IV Cryoglobulinemia Severe/symptomatic Plasmapheresis I Secondary to Hepatitis C Immunoadsorption II Cutaneous T cell lymphoma: mycosis fungoides or Sézary disease Erythrodermic Photopheresis I Non-erythrodermic III Dermatomyositis or polymyositis Plasmapheresis IV Leukapheresis IV Dilated cardiomyopathy NYHA class II-IV Immunoadsorption or plasmapheresis III Familial hypercholesterolemia Homozygotes LDL<unk>  I Heterozygotes II Homozygotes with small blood volume Plasmapheresis II Focal segmental glomerulosclerosis Recurrent Plasmapheresis I Graft-versus-host disease Skin Plasmapheresis II Non-skin III Hemolytic disease of the fetus Before intrauterine transfusion availability Plasmapheresis II Hereditary hemochromatosis Erythrocytapheresis III Hemolytic uremic syndrome (HUS) Atypical HUS due to mutations in complement factor genes Plasmapheresis II Atypical HUS due to factor H autoantibodies I Typical HUS, or diarrhea-associated HUS IV Leukocytosis Leukostasis Leukapheresis I Prophylaxis of leukostasis III Hyperviscosity in monoclonal gammopathy Treatment of symptoms Plasmapheresis I Prophylaxis in rituximab Immune thrombocytopenic purpura Plasmapheresis IV Immune complex-type of rapidly progressive glomerulonephritis Plasmapheresis III Inclusion body myositis Plasmapheresis or leukapheresis IV Inflammatory bowel disease Leukapheresis II Kidney transplantation Antibody-mediated rejection Plasmapheresis I Desensitization (medicine) in living donor in positive crossmatch due to donor specific HLA antibody II High PRA and cadaveric donor III Lambert-Eaton myasthenic syndrome Plasmapheresis II Lung transplantation Allograft rejection Plasmapheresis II Malaria Severe Erythrocytapheresis II Multiple sclerosis Acute inflammatory demyelinating disease of the central nervous system, unresponsive to steroids Plasmapheresis II Chronic progressive III Myasthenia gravis Moderate to severe Plasmapheresis I Pre-thymectomy I Myeloma cast nephropathy Plasmapheresis II Nephrogenic systemic fibrosis Photopheresis or Plasmapheresis III Neuromyelitis optica Plasmapheresis II Venoms, poisoning and overdose Mushroom poisoning Plasmapheresis II Other III Paraneoplastic syndrome Neurologic Plasmapheresis or immunoadsorption III Pancreatitis Secondary to hypertriglyceridemia Plasmapheresis III Polyneuropathy due to monoclonal gammopathy IgG, IgA or IgM Plasmapheresis I Multiple myeloma III IgG/IgA or IgM Immunoadsorption III PANDAS and Sydenham's chorea Plasmapheresis I Pemphigus vulgaris Plasmapheresis IV Photopheresis III Refsum disease Plasmapheresis II Polycythemia vera or erythrocytosis Erythrocytapheresis III POEMS syndrome Plasmapheresis IV Post-transfusion purpura Plasmapheresis III Psoriasis Plasmapheresis IV Rheumatoid arthritis Refractory Immunoadsorption II Schizophrenia Plasmapheresis IV Systemic scleroderma Plasmapheresis III Photopheresis IV Sepsis with multiorgan failure Plasmapheresis III Sickle cell disease Acute stroke Erythrocytapheresis I Acute chest syndrome II Prophylaxis of stroke or transfusional iron overload II Multi-organ failure III Stiff-person syndrome Plasmapheresis IV Systemic lupus erythematosus Severe, such as cerebritis or diffuse alveolar hemorrhage Plasmapheresis II Nephritis IV Thrombocytosis Symptomatic Plateletpheresis II Prophylactic III Thrombotic microangiopathy, drug-associated * Ticlopidine * Clopidogrel Plasmapheresis I * Cyclosporine * Tacrolimus III * Gemcitabine * Quinine IV Thrombotic microangiopathy, hematopoietic stem cell transplantation-related Plasmapheresis III Thrombotic thrombocytopenic purpura Plasmapheresis I Thyroid storm Plasmapheresis III Wilson's disease Fulminant hepatic failure with hemolysis Plasmapheresis I
Apheresis
Photopheresis
Dialysis
Aquapheresis
Rheopheresis
Iridodialysis
Plasmapheresis
Hemoperfusion