Abnormal duplication of the EGFR gene is a relatively infrequent phenomenon in SCL (>/= 4 copies in >/= 40% of cells in 5/22) Overexpression of the EGFR protein occurs in nearly all cases (22/22). Mutations of the EGFR gene are relatively rare (0/23). K-ras mutations found in 8/22 cases (Gly12Cys in 6 cases and Gly12Val in 2 cases) SCL show intense immune infiltration which is predominantly neutrophillic. However the tumors evade the immune system by increased expression of a negative regulator of T-cells mainly programmed death ligand-1.
Sarcomatoid carcinoma of the lung
Epithelial-myoepithelial carcinoma of the lung
Giant-cell carcinoma of the lung
Pulmonary sclerosing pneumocytoma
Mucinous cystadenocarcinoma of the lung
Adenocarcinoma of the lung
Salivary gland–like carcinoma of the lung
Adenosquamous lung carcinoma