These medications are used in the treatment of many conditions, such as: * Dyspepsia * Peptic ulcer disease including after endoscopic treatment for bleeding * As part of Helicobacter pylori eradication therapy * Gastroesophageal reflux disease (GERD or GORD) including symptomatic endoscopy-negative reflux disease and associated laryngopharyngeal reflux causing laryngitis and chronic cough * Barrett's esophagus * Eosinophilic esophagitis * Stress<unk>  and ulcer prevention in critical care * Gastrinomas and other conditions that cause hypersecretion of acid including Zollinger–Ellison syndrome (often 2–3x the regular dose is required) Specialty professional organizations recommend that people take the lowest effective PPI dose to achieve the desired therapeutic result when used to treat gastroesophageal reflux disease long-term. In the United States, the Food and Drug Administration (FDA) has advised that over-the-counter PPIs, such as Prilosec OTC, should be used no more than three 14-day treatment courses over one year. Despite their extensive use, the quality of the evidence supporting their use in some of these conditions is variable. The effectiveness of PPIs has not been demonstrated for every case. For example, although they reduce the incidence of esophageal adenocarcinoma in Barrett's oesophagus, they do not change the length affected. Indications for stopping PPIs PPIs are often used longer than necessary. In about half of people who are hospitalized or seen at a primary care clinic there is no documented reason for their long-term use of PPIs. Some researchers believe that, given the little evidence of long-term effectiveness, the cost of the medication and the potential for harm means that clinicians should consider stopping PPIs in many people. After four weeks, if symptoms have resolved, the PPI may be stopped in those who were using them for heartburn, gastroesophageal reflux disease, or inflammation of the esophagus if these last two were not severe. Stopping is not recommended in those with Barrett's esophagus or a bleeding stomach ulcer. Stopping may be carried out by first decreasing the amount of medication taken or having the person take the medication only when symptoms are present.
treatment of Gastritis
medication of Peptic ulcer disease
medication of Gastroesophageal reflux disease
medication of Helicobacter pylori
medication of Gastrointestinal bleeding
treatment of Cardiovascular disease
treatment of Eating disorder
treatment of Opioid use disorder