<unk> , also known as estradiol 3-normustine 17β-phosphate or as estradiol 3-(bis(2-chloroethyl)carbamate) 17β-(dihydrogen<unk> , is a synthetic estrane steroid and a derivative of estradiol. It is an estrogen ester; specifically,<unk>  is a diester of estradiol with a C3 normustine (nitrogen mustard–carbamate moiety) ester and a C17β<unk>  ester.<unk>  is provided as the sodium or meglumine salt.<unk>  is similar as a compound to other estradiol esters such as estradiol sulfate and estradiol valerate, but differs in the presence of its nitrogen mustard ester moiety. Antineoplastic agents related to<unk> , although none of them were marketed, include alestramustine, atrimustine, cytestrol acetate, estradiol mustard, ICI-85966, and phenestrol. Due to its hydrophilic<unk>  ester moiety,<unk>  is a readily water-soluble compound. This is in contrast to most other estradiol esters, which are fatty acid esters and lipophilic compounds that are not particularly soluble in water. Unlike<unk> ,<unk>  is highly lipophilic, practically insoluble in water, and non-ionizable. The<unk>  ester of<unk>  was incorporated into the molecule in order to increase its water solubility and allow for intravenous administration. The molecular weight of<unk>  sodium is 564.3 g/mol, of<unk>  meglumine is 715.6 g/mol, of<unk>  is 520.4 g/mol, of<unk>  is 440.4 g/mol, and of estradiol is 272.4 g/mol. As a result of these differences in molecular weights,<unk>  contains about 52%,<unk>  sodium about 48%, and<unk>  meglumine about 38% of the amount of estradiol within their structures as does an equal-mass quantity of estradiol.
Estramustine phosphate
Normustine
GemOx
Bendamustine
Paclitaxel
Lomustine
Ifosfamide
Trifluridine