Pharmacodynamics<unk>  has both anabolic and androgenic effects. Once metabolized,<unk>  esters have the effect of increasing ammonium ion uptake by muscles, leading to an increase in the rate of protein synthesis. It may also have the secondary effects of stimulating appetite and decreasing the rate of catabolism, as all anabolic steroids are believed to; however, catabolism likely increases significantly once the steroid is no longer taken. At least one study in rats has shown<unk>  to cause gene expression of the androgen receptor (AR) at least as potent as dihydrotestosterone (DHT). This evidence tends to indicate<unk>  can cause an increase in male secondary sex characteristics without the need to convert to a more potent androgen in the body. Studies on metabolism are mixed, with some studies showing that it is metabolized by aromatase or 5α-reductase into estrogenic compounds, or into 5α-reduced androgenic compounds, respectively.<unk>  has potency five times as high as that of testosterone.<unk>  also binds with high affinity to the progesterone receptor,<unk>  binds to the glucocorticoid receptor, as well. Pharmacokinetics To prolong its elimination half-life,<unk>  is administered as a prodrug as an ester conjugate such as<unk>  acetate,<unk>  enanthate, or<unk>  hexahydrobenzylcarbonate. Plasma lipases then cleave the ester group in the bloodstream leaving free<unk> .<unk>  and 17-epitrenbolone are both excreted in urine as conjugates that can be hydrolyzed with beta-glucuronidase. This implies that<unk>  leaves the body as beta-glucuronides or sulfates.
Trenbolone
Oxendolone
Oxymetholone
Metenolone
Ganaxolone
Stenbolone
Methylstenbolone
Trestolone