<unk>  <unk> , also known as Asherson's<unk> , is a rare autoimmune disease in which widespread, intravascular clotting causes multi-organ failure. The<unk>  is caused by antiphospholipid antibodies that target a group of proteins in the body that are associated with phospholipids. These antibodies activate endothelial cells, platelets, and immune cells, ultimately causing a large inflammatory immune response and widespread clotting.<unk>  was first described by Ronald Asherson in 1992. The<unk>  exhibits thrombotic microangiopathy, multiple organ thromboses, and in some cases tissue necrosis and is considered an extreme or<unk>  variant of the antiphospholipid<unk> .<unk>  has a mortality rate of about 50%. With the establishment of a<unk> -Registry more has been learned about this<unk> , but its cause remains unknown. Infection, trauma, medication, and/or surgery can be identified in about half the cases as a "trigger". It is thought that cytokines are activated leading to a cytokine storm with the potentially fatal consequences of organ failure. A low platelet count is a common finding.
Catastrophic antiphospholipid syndrome
Antiphospholipid syndrome
Primary fibrinogenolysis
Protein C deficiency
Factor VII deficiency
Antithrombin III deficiency
Warfarin resistance
Giant platelet disorder