Shannon et al. observed in 1932 that dogs had an increased renal function after high protein meals – which they termed "renal function reserve". Activation of this "reserve" or extra-renal function has been suggested as a potential mechanism for ARC in severe illness. The administration of medications which increase blood flow to the kidneys has also been considered a potential cause of ARC, including administration of fluids. Some medications which have been thought to cause increased renal<unk>  include norepinephrine and other vasopressors. While medications may increase renal<unk> , many patients with severe illness have higher<unk>  prior to the initiation of these medications.<unk>  also may occur in people who have some types of cancers, such as hematologic cancers. In these people, the efficacy of antibiotic treatment may be decreased if the increased<unk>  is not accounted for.
Augmented renal clearance
Enhanced permeability and retention effect
Bioconcentration
Electrolyte exclusion effect
Natriuresis
Renal compensation
Prostatic congestion
Adrenal fatigue