<unk>  is commonly found in patients with diseases of the connective tissue and an increased inflammatory response such as Marfan syndrome and Kawasaki Disease. It can also be found transiently in patients that have undergone stent placement resulting in the stretching of the vessels 1.<unk>  is characterized by an increased wall stress of the vessel, thinning of the arterial wall which causes progressive dilation and remodelling of the vessel. The permanent dilation of the artery is thought to be mainly caused by inflammation, triggered by disease, chemicals, or physical stress of the vessel. A meta-analysis study has shown that The pooled unadjusted OR of<unk>  in subjects with HTN in comparison by subjects without HTN was estimated 1.44 (95 % CI, 1.24 to 1.68) Bahremand, M., Zereshki, E., Matin, B.K. et al. Hypertension and<unk> : a systematic review and meta-analysis study. Clin Hypertens 27, 14 (2021). https://doi.org/10.1186/s40885-021-00170-6.The inflammatory response results in an over expression of matrix metalloproteinases, cysteine proteinases, and serine proteinases that causes the partial breakdown of the vessel and weakens it. The inflammation response will also trigger platelet activation which increases the risk of blood clots. The risk of blood clots will increase due to the turbulent blood flow of the enlarged vessel which can activate platelets and form clots. Inflammation elevated oxidative stress is increased, and antioxidant activity is depressed in<unk> . This imbalance can cause damage to the cells and cause them to die, weakening the vessels further. The activation of the inflammatory response causes a detectable increase in C reactive protein, interleukin-6, tumor necrosis factor alpha and cell adhesion molecules, which can be used as a diagnostic marker,.
Coronary artery ectasia
Coronary artery aneurysm
Coronary thrombosis
Ventricular aneurysm
Thoracic aortic aneurysm
Cardiac myxoma
Microvascular angina
Arteriosclerotic heart disease