<unk>  acts as a selective dual D2 receptor antagonist and acetylcholinesterase inhibitor. There is evidence that<unk>  may have prokinetic effects throughout the gastrointestinal tract from the stomach to the end of the colon. The pharmacokinetics of<unk>  appear to differ between Asian and Caucasian populations, with Caucasians having 30-50 percent lower blood levels of<unk>  after oral administration.<unk>  poorly penetrates across the blood brain barrier because of its high polarity and thus<unk>  does not tend to cause any central nervous system adverse effects.<unk>  has no effect on potassium channels. Similarly to other D2 receptor antagonists,<unk>  has been found to dose-dependently increase prolactin levels. Pharmacokinetics After oral administration<unk>  undergoes rapid and extensive absorption with levels of<unk>  peaking in the blood plasma after only 35 minutes.<unk>  is primarily eliminated via the kidneys having an elimination half-life of approximately 6 hours. Mechanism of action Ganaton<unk>  50 mg tablets. Engraving says "HC 803"<unk>  increases acetylcholine concentrations by inhibiting dopamine D2 receptors and acetylcholinesterase. Higher acetylcholine increases GI peristalsis, increases the lower esophageal sphincter pressure, stimulates gastric motility, accelerates gastric emptying, and improves gastro-duodenal coordination.<unk>  given as a single dose study found that it also raises levels of motilin, somatostatin and lowers levels of cholecystokinin, as well as adrenocorticotropic hormone. These effects may also contribute to<unk> 's pharmacology.
Itopride
Bromopride
Prucalopride
Tasimelteon
Cinitapride
Nyasol
Mitapivat
Icatibant