At birth, there is no sign that a child will develop symptoms of<unk> . Typically, signs and symptoms become apparent between two and four years of age and become progressively worse as the individual ages. The following signs and symptoms may appear: * Individuals are more prone to respiratory infections * Development of scoliosis * Seizures or difficulty with movement * Skin and joints may become loose * Facial features change progressively; this may include: ::::# thickening of the skin ::::# features becoming more prominent ::::# large head ::::# broad lower jaw ::::# short, broad nose ::::# rounded cheeks * Progression of developmental and mental disabilities, including: ::::# progressive loss of speech ::::# decrease in mental functioning ::::# before school age, concentration lowers ::::# development continues, but becomes slower than usual * An intellectual peak occurs in the mid-teens and allows a plateau for the disease. Once an individual hits the age of 25-30 the decrease begins again, including: ::::# learned skills become lost which result in severe learning disabilities ::::# motor skills deteriorate ::::# individuals become less mobile and more dependent (Children are physically uncoordinated, but remain able to play sports and do everyday activities until they reach adulthood.) * During the first year of life inguinal and umbilical hernias are common. * Less severe symptoms include: ::::# enlargement of the spleen and liver ::::# diarrhea * People with<unk>  may have lower than average height, because they tend to go through puberty earlier. * Epilepsy may develop in adulthood. * Finnish studies have shown that life expectancy is shorter than average.
Aspartylglucosaminuria
Hawkinsinuria
Alkaptonuria
Essential fructosuria
Orotic aciduria
Cystathioninuria
Dicarboxylic aminoaciduria
Urocanic aciduria