Some patients have no symptoms, spontaneous remission, or a relapsing/remitting course, making it difficult to decide whether therapy is needed. In 2002, authors from Sapienza University of Rome stated on the basis of a comprehensive literature review that "clinical observation without treatment is advisable when possible". Therapeutic options include surgery, radiation therapy, and chemotherapy. Surgery is used to remove single lymph nodes, central nervous system lesions, or localized cutaneous disease. In 2014, Dalia and colleagues wrote that for patients with extensive or systemic Destombes–Rosai–Dorfman disease, "a standard of care has not been established" concerning radiotherapy and chemotherapy.
Rosai–Dorfman disease
Mowat–Wilson syndrome
Akureyri disease
Wilson–Mikity syndrome
Wilson's disease
BENTA disease
Batten disease
Keshan disease