Spasticity () is a feature of altered skeletal muscle performance with a combination of paralysis, increased tendon reflex activity, and hypertonia. It is also colloquially referred to as an unusual "tightness", stiffness, or "pull" of muscles. Clinically, spasticity results from the loss of inhibition of motor neurons, causing excessive velocity-dependent muscle contraction. This ultimately leads to hyperreflexia, an exaggerated deep tendon reflex. Spasticity is often treated with the drug baclofen, which acts as an agonist at GABA receptors, which are inhibitory. Spastic cerebral palsy is the most common form of cerebral palsy, which is a group of permanent movement problems that do not get worse over time. GABA's inhibitory actions contribute to baclofen's efficacy as an anti-spasticity agent.
symptom of Amyotrophic lateral sclerosis
symptom of Multiple sclerosis
symptom of Myotonic dystrophy
symptom of Duchenne muscular dystrophy
symptom of Progressive supranuclear palsy
symptom of Japanese encephalitis
symptom of Myasthenia gravis
symptom of Romano–Ward syndrome