<unk>  overdose usually presents with the following symptoms: * Signs of central nervous system depression such as: * stupor * coma * drowsiness * restlessness * ataxia * Mydriasis * Convulsions * Enhanced reflexes * Muscle rigidity * Athetoid and choreoathetoid movements * Serotonin syndrome - a condition with many of the same symptoms as neuroleptic malignant syndrome but has a significantly more rapid onset * Cardiovascular effects including: * arrhythmias (including Torsades de pointes) * tachycardia * QTc interval prolongation * conduction disorders * hypotension * shock * heart failure * cardiac arrest * Apnoea * Cyanosis * Respiratory depression * Vomiting * Fever * Sweating * Oliguria * Anuria There is no specific antidote for overdose and all treatment is purely supportive and symptomatic. Treatment with activated charcoal may be used to limit absorption in cases of oral overdose. Anyone suspected of overdosing on<unk>  should be hospitalised and kept under close surveillance for at least 72 hours.<unk>  has been reported as being less toxic in overdose than most other TCAs in one meta-analysis but this may well be due to the circumstances surrounding most overdoses as<unk>  is more frequently used to treat conditions for which the rate of suicide is not particularly high such as OCD. In another meta-analysis, however,<unk>  was associated with a significant degree of toxicity in overdose.
Clomipramine
Trimipramine
Desipramine
Carpipramine
Imipramine
Sertraline
Citalopram
Escitalopram