Niacin deficiency Niacinamide is the preferred treatment for pellagra, caused by niacin deficiency. while niacin may be used, niacinamide has the benefit of not causing skin flushing. Acne Niacinamide cream is used as a treatment for acne. It has anti-inflammatory actions, which may benefit people with inflammatory skin conditions. Niacinamide increases the biosynthesis of ceramides in human keratinocytes in vitro and improves the epidermal permeability barrier in vivo. The application of 2% topical niacinamide for 2 and 4 weeks has been found to be effective in lowering the sebum excretion rate. Niacinamide has been shown to prevent Cutibacterium acnes-induced activation of toll-like receptor 2, which ultimately results in the down-regulation of pro-inflammatory interleukin-8 production. Other skin benefits from topical niacinamide may include relief to a stripped moisture barrier in the skin, reduced irritation, increase of collagen production, and the lessening of hyperpigmentation in one's skin. Skin cancer Niacinamide at doses of 500 to 1000 mg a day decreases the risk of skin cancers, other than melanoma, in those at high risk.
Nicotinamide
Carnitine
Inositol
Choline
Cysteamine
Phenserine
Uridine triacetate
Creatine