<unk>  (developmental code name ICI-55,548) is a major metabolite of tamoxifen, a selective estrogen receptor modulator (SERM).<unk>  is further metabolized into endoxifen (4-hydroxy-N-desmethyltamoxifen), which is thought to be the major active form of tamoxifen in the body. In one study,<unk>  had an affinity for the estrogen receptor of 2.4% relative to estradiol. For comparison, tamoxifen, endoxifen, and afimoxifene (4-hydroxytamoxifen) had relative binding affinities of 2.8%, 181%, and 181%, respectively.
N-Desmethyltamoxifen
N,N-Didesmethyltamoxifen
Tamoxifen
Endoxifen
N-Desmethylenzalutamide
Salvestrol
Anastrozole
Acetothiolutamide