Depiction of the pathway that<unk>  (t-PA) uses to promote the degradation of a blood clot (fibrin).<unk>  binds to fibrin in a blood clot and activates the clot-bound plasminogen.<unk>  cleaves plasminogen at the site of its Arg561-Val562 peptide bond to form plasmin. Plasmin is a fibrinolytic enzyme that cleaves the cross-links between polymerized fibrin molecules, causing the blood clot to break down and dissolve, a process called fibrinolysis. Regulation and inhibition Plasminogen activator inhibitor 1 stops<unk>  activity by binding to it and forming an inactive complex, which is removed from the bloodstream by the liver. Fibrinolysis by plasmin is extremely short-lived due to plasmin inhibitors, which inactivate and regulate plasmin activity.
Alteplase
Tenecteplase
Desmoteplase
Argatroban
Prasugrel
Rivaroxaban
Ticagrelor
Lusutrombopag