<unk>  is a heterogenous group of inherited neurodegenerative diseases, still under research, in which<unk>  accumulates in the basal ganglia, either resulting in progressive dystonia, Parkinsonism, spasticity, optic atrophy, retinal degeneration, neuropsychiatric, or diverse neurologic abnormalities. Some of the<unk>  disorders have also been associated with several genes in synapse and lipid metabolism related pathways.<unk>  is not one disease but an entire group of disorders, characterized by an<unk>  of<unk> <unk> , sometimes in the presence of axonal spheroids in the central nervous system.<unk><unk>  can occur anywhere in the<unk> , with<unk>  typically occurring in globus pallidus, substantia nigra, pars reticula, striatum and cerebellar dentate nuclei. Symptoms can include various movement disorders, neuropsychiatric issues, seizures, visual disturbances, and cognitive decline, usually in different combinations. 10-15 genetic<unk>  disorders have been identified involved in various cell processes:<unk>  metabolism, coenzyme A biosynthesis, phospholipid metabolism, ceramide metabolism, lysosomal disorders, as well as mutations in genes with unknown functions. Onset can occur at different ages, from early childhood to late adulthood. There are currently no curative treatments for any of the<unk>  disorders, though several medications have been subject to clinical trial including the<unk>  chelator deferiprone.
Neurodegeneration with brain iron accumulation
Leukoencephalopathy with vanishing white matter
Leukoencephalopathy with neuroaxonal spheroids
Megalencephalic leukoencephalopathy with subcortical cysts
Variably protease-sensitive prionopathy
Chronic traumatic encephalopathy in sports
Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations
Limbic-predominant age-related TDP-43 encephalopathy