The granular, cytoplasmic staining pattern of<unk> <unk> s, or PR3-ANCA, or antineutrophil cytoplasmic antibodies, are a type of autoantibody, an antibody produced by the body that acts against one of its own proteins. These antibodies show a diffusely granular, cytoplasmic staining pattern under microscopy. This pattern results from binding of<unk> s to antigen targets throughout the neutrophil cytoplasm, the most common protein target being proteinase 3 (PR3). For example, PR3 is the most common antigen target of<unk>  in patients with granulomatosis with polyangiitis. In active granulomatosis with polyangiitis,<unk>  is found over 90% of the time. Other antigens may also occasionally result in a<unk>  pattern.
C-ANCA
ANA-12
Anti-neutrophil cytoplasmic antibody
Anti-nuclear antibody
Anti-LKM antibody
Rheumatoid factor
Anti–citrullinated protein antibody
HLA-DQB1