<unk>  is an electrocardiographic manifestation of critical proximal left anterior descending (LAD) coronary artery stenosis in people with unstable angina. Originally thought of as two separate types, A and B, it is now considered an evolving wave form, initially of biphasic T wave inversions and later becoming symmetrical, often deep (>2 mm), T wave inversions in the anterior precordial leads. First described by Hein J. J.<unk>  and colleagues in 1982 in a subgroup of people with unstable angina, it does not seem to be rare, appearing in 18% of patients in his original study. A subsequent prospective study identified this<unk>  in 14% of patients at presentation and 60% of patients within the first 24 hours. The presence of<unk>  carries significant diagnostic and prognostic value. All people in the De Zwann's study with characteristic findings had more than 50% stenosis of the left anterior descending artery (mean = 85% stenosis) with complete or near-complete occlusion in 59%. In the original<unk> ' study group, 75% of those with the typical<unk>  manifestations had an anterior myocardial infarction. Sensitivity and specificity for significant (more or equal to 70%) stenosis of the LAD artery was found to be 69% and 89%, respectively, with a positive predictive value of 86%.<unk> ' sign has also been seen as a rare presentation of Takotsubo cardiomyopathy or stress cardiomyopathy. __TOC__
Wellens' syndrome
Mortimer's disease
Löffler's syndrome
Rowell's syndrome
Banti's syndrome
Fowler's syndrome
Woodhouse–Sakati syndrome
Grisel's syndrome