<unk> <unk> , also known as nonclassic congenital adrenal<unk>  (NCCAH or NCAH), is a milder form of congenital adrenal<unk>  (CAH), a group of autosomal recessive disorders characterized by impaired cortisol synthesis that leads to variable degrees of postnatal androgen excess. The causes of<unk>  are the same as of classic CAH, and in the majority of the cases are the mutations in the CYP21A2 gene resulting in corresponding activity changes in the associated P450c21 (21-hydroxylase) enzyme which ultimately leads to excessive androgen production. Other causes, albeit less frequent, are mutations in genes affecting other enzymes involved in steroid metabolism, like 11β-hydroxylase or 3β-hydroxysteroid dehydrogenase. It has a prevalence between 0.1% and 2% depending on population, and is one of the most common autosomal recessive genetic diseases in humans. The pathophysiology is complex and not all individuals are symptomatic.
Late onset congenital adrenal hyperplasia
Lipoid congenital adrenal hyperplasia
Congenital adrenal hyperplasia
Primary pigmented nodular adrenocortical disease
Multiple endocrine neoplasia type 1
Multiple endocrine neoplasia type 2
Multiple endocrine neoplasia
Persistent adrenarche syndrome