Mechanism of action<unk>  is of the nitroimidazole class. It inhibits nucleic acid synthesis by forming nitroso radicals, which disrupt the DNA of microbial cells. This function only occurs when<unk>  is partially reduced, and because this reduction usually happens only in anaerobic bacteria and protozoans, it has relatively little effect upon human cells or aerobic bacteria. Pharmacokinetics Hydroxymetronidazole, the main<unk> abolite Oral<unk>  is approximately 80% bioavailable via the gut and peak blood plasma concentrations occur after one to two hours. Food may slow down absorption but does not diminish it. Of the circulating substance, about 20% is bound to plasma proteins. It penetrates well into tissues, the cerebrospinal fluid, the amniotic fluid and breast milk, as well as into abscess cavities. About 60% of the<unk>  is<unk> abolized by oxidation to the main<unk> abolite hydroxymetronidazole and a carboxylic acid derivative, and by glucuronidation. The<unk> abolites show antibiotic and antiprotozoal activity in vitro.<unk>  and its<unk> abolites are mainly excreted via the kidneys (77%) and to a lesser extent via the faeces (14%). The biological half-life of<unk>  in healthy adults is eight hours, in infants during the first two months of their lives about 23 hours, and in premature babies up to 100 hours. The biological activity of hydroxymetronidazole is 30% to 65%, and the elimination half-life is longer than that of the parent compound. The serum half-life of hydroxymetronidazole after suppository was 10 hours, 19 hours after intravenous infusion, and 11 hours after a tablet.
Metronidazole
Secnidazole
Fexinidazole
Tinidazole
Benznidazole
Meropenem
Ornidazole
Norfloxacin