<unk>  is contraindicated in the following populations and situations: * people with a known hypersensitivity to<unk> , substituted benzimidazoles (which are chemically similar to<unk> , like omeprazole), or any other component of the capsule formulation (e.g. certain dyes) * concurrent use of rilpivirine, a medication used to treat HIV infection Hypersensitivity Syndrome An allergy to a PPI like<unk>  may take the form of type I hypersensitivity or delayed hypersensitivity reactions. A selective (pattern C—see below for a discussion of cross-reactivity patterns) type I hypersensitivity reaction to<unk>  resulting in anaphylaxis has been reported, as well as several whole group hypersentivities. Cross-reactivity Hypersensitivity to PPIs can take the form of whole group hypersensitivity, pattern A, B, or C. Whole group hypersentivity occurs when a person is cross-reactive to all PPIs; that is, all PPIs will induce the allergy. In pattern A, a person may be allergic to omeprazole, esomeprazole, and pantoprazole, but not to lansoprazole and<unk> . This is thought to be due to the structural similarities between omeprazole, esomeprazole, and pantoprazole, contrasted with lansoprazole and<unk> . Pattern B is the opposite, reflecting people that are allergic to lansoprazole and<unk> , but not to omeprazole, esomeprazole, and pantoprazole. Pattern C, in the context of<unk> , would reflect a person that is allergic to only<unk> , but not to other PPIs (omeprazole, esomeprazole, pantoprazole, and lansoprazole). Rilpivirine Rilpivirine, a non-nucleoside reverse transcriptase inhibitor used in the treatment of HIV, is contraindicated with all PPIs because of their acid-suppressing effect. PPIs suppress acid, thereby raising the pH of (alkalizing) the stomach's contents. Rilpivirine is best absorbed under acidic conditions. Therefore,<unk>  would be expected to decrease the absorption of rilpivirine, decrease the concentration of rilpivirine in the blood, and possibly lead to therapeutic failure and resistance to the medication/class.
Rabeprazole
Esomeprazole
Lansoprazole
Omeprazole
Dexlansoprazole
Tenatoprazole
Pantoprazole
Cimetidine