Until 2008, a distinction was made between two types: complicated<unk> s (cSSSIs) and uncomplicated<unk> s (uSSSIs), which had different regulatory approval requirements. Uncomplicated<unk> s included "simple abscesses, impetiginous lesions, furuncles, and cellulitis." Complicated<unk> s included "infections either involving deeper soft tissue or requiring significant surgical intervention, such as infected ulcers, burns, and major abscesses or a significant underlying disease state that complicates the response to treatment." The FDA further noted that "superficial infections or abscesses in an anatomical site, such as the rectal area, where the risk of anaerobic or Gram-negative pathogen involvement is higher, were also considered complicated infections." The uncomplicated category (uSSSI) is most frequently caused by Staphylococcus aureus and Streptococcus pyogenes, whereas the complicated category (cSSSI) might also be caused by a number of other pathogens. As of 2013, the pathogen involved in cases of cSSSI were known about 40% of the time.
Skin and skin structure infection
Waterborne diseases
Autoimmune/inflammatory syndrome induced by adjuvants
Mouth infection
Skin infection
Multidrug-resistant bacteria
Infectious diseases 
Intestinal infectious diseases