<unk>  <unk>  is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland.<unk>  is secreted and accumulated at hundreds of grams per litre in the extracellular compartment of the thyroid follicles, accounting for approximately half of the protein content of the thyroid gland. Human<unk>  (hTG) is a homodimer of subunits each containing 2768 amino acids as synthesized (a short signal peptide of 19 aminoacids may be removed from the N-terminus in the mature protein).<unk>  is in all vertebrates the main precursor to thyroid hormones, which are produced when<unk> 's tyrosine residues are combined with iodine and the protein is subsequently cleaved. Each<unk>  molecule contains approximately 100-120 tyrosine residues, but only a small number (20) of these are subject to iodination by thyroperoxidase in the follicular colloid. Therefore, each<unk>  molecule forms approximately 10 thyroid hormone molecules.
Thyroglobulin
Gamma globulin
Parathyroid hormone
Hepcidin
Haptocorrin
Modulin
Ovoferrin
Orexin