Definitive diagnosis of these tumours is based on the histology of tissue obtained in a biopsy or surgical resection. In a retrospective study of 72 cases in children and adolescents, the histology was important to prognosis. A number of molecules have been proposed as markers for this group of tumours. CD56 may be useful for distinguishing<unk> <unk><unk><unk>  tumours from some other types of tumours, although it does not distinguish them from neuroendocrine tumours. Calretinin has also been suggested as a marker. For diagnosis of granulosa cell tumour, inhibin is under investigation. Granulosa cell tumors and Sertoli-Leydig cell tumors have specific genetic mutations that are characteristic and can help support the diagnosis. On magnetic resonance imaging, a fibroma may produce one of several imaging features that might be used in the future to identify this rare tumour prior to surgery. Image:Granulosa cell tumour1.Low magnification micrograph of a granulosa cell tumour. H&E stain. Image:Thecoma high mag.High magnification micrograph of a thecoma. H&E stain. Image:Thecoma low mag.Low magnification micrograph of a thecoma. H&E stain. Image:Leydig cell tumour1.Low magnification micrograph of a Leydig cell tumour. H&E stain. Image:Leydig cell tumour2.Intermediate magnification micrograph of a Leydig cell tumour. H&E stain. Image:Leydig cell tumour3.High magnification micrograph of a Leydig cell tumour. H&E stain. Image: Sertoli cell tumour low mag.Low magnification micrograph of a Sertoli cell tumour. H&E stain. Image: Sertoli cell tumour high mag.High magnification micrograph of a Sertoli cell tumour. H&E stain.
Sex cord–gonadal stromal tumour
Sertoli cell tumour
Granulosa cell tumour
Germ cell tumor
Ovarian germ cell tumors
Dysgerminoma
Leydig cell tumour
Gonadoblastoma