<unk>  <unk> , also known as Bridges–Good syndrome,<unk><unk>  disorder, and Quie syndrome, is a diverse group of hereditary<unk> s in which certain cells of the immune system have difficulty forming the reactive oxygen compounds (most importantly the superoxide radical due to defective phagocyte NADPH oxidase) used to kill certain ingested pathogens. This leads to the formation of granulomas in many organs.<unk>  affects about 1 in 200,000 people in the United States, with about 20 new cases diagnosed each year. This condition was first discovered in 1950 in a series of 4 boys from Minnesota, and in 1957 it was named "a fatal<unk>  of childhood" in a publication describing their<unk> . The underlying cellular mechanism that causes<unk>  was discovered in 1967, and research since that time has further elucidated the molecular mechanisms underlying the<unk> . Bernard Babior made key contributions in linking the defect of superoxide production of white blood cells, to the cause of the<unk> . In 1986, the X-linked form of<unk>  was the first<unk>  for which positional cloning was used to identify the underlying genetic mutation.
Chronic granulomatous disease
Common variable immunodeficiency
Wiskott–Aldrich syndrome
Severe combined immunodeficiency
Primary immunodeficiency
X-linked agammaglobulinemia
Selective immunoglobulin A deficiency
SAPHO syndrome