The most common indication for<unk>  is management of migraine using the intranasal spray formulation. It may also be used parenterally for management of moderate-to-severe pain, as a supplement for balanced general anesthesia, and management of pain during labor.<unk>  is also quite effective at reducing post-operative shivering (owing to its Kappa agonist activity).<unk>  is more effective in reducing pain in women than in men.
Butorphanol
Levorphanol
Morphine
Oxymorphol
Hydromorphone
Oxymorphone
Noroxycodone
Nalorphine