The pathophysiology of<unk>  can be divided into congenital and acquired. The congenital<unk>  (severe and cyclic type) is autosomal dominant, with mutations in the ELA2 gene (neutrophil elastase) as the most common genetic reason for this condition. Acquired<unk>  (immune-associated<unk>  is due to anti-neutrophil antibodies that target neutrophil-specific antigens, ultimately altering neutrophil function. Furthermore, emerging research suggests<unk>  without an identifiable etiology (idiopathic<unk>  may be the result of a low-grade, chronic inflammatory process with an abnormal excessive production of myelosuppressive cytokines in a study conducted in the island of Crete.<unk>  fever can complicate the treatment of cancers. Observations of children noted that fungal infections are more likely to develop in those with<unk> . Mortality increases during cancer treatments if<unk>  is also present. Congenital<unk>  is determined by blood neutrophil counts (absolute neutrophil counts or ANC) < 0.5 × 10/L and recurrent bacterial infections beginning very early in childhood.Congenital<unk>  is related to alloimmunization, sepsis, maternal hypertension, twin-to-twin transfusion syndrome, and Rh hemolytic disease.
Neutropenia
Monocytosis
Macrocytosis
Poikilocytosis
Mastocytosis
Monocytopenia
Hypersegmented neutrophil
Dyscrasia