In terms of pathophysiology, clinical, physiological and imaging studies point to an involvement of the cerebellum and/or cerebellothalamocortical circuits. Changes in the cerebellum could also be mediated by alcoholic beverage consumption. Purkinje cells are especially susceptible to<unk> hanol excitotoxicity. Impairment of Purkinje synapses is a component of cerebellar degradation that could underlie<unk> . Some cases have Lewy bodies in the locus ceruleus.<unk>  cases that progress to Parkinson's disease are less likely to have had cerebellar problems. Recent neuroimaging studies have suggested that the efficiency of the overall brain functional network in<unk>  is disrupted. Recent post mortem studies have evidenced alterations in (leucine-rich repeat and Ig domain containing 1 (LINGO1) gene and GABA receptors in the cerebellum of people with<unk> . HAPT1 mutations have also been linked to<unk> , as well as to Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. In 2012, the National Toxicology Program concluded that sufficient evidence exists of an association between blood lead exposure at levels >10 μg/dl and<unk>  in adults, and limited evidence at blood lead levels >5 μg/dl.
Essential tremor
Dystonia
Holmes tremor
Intention tremor
Myoclonic dystonia
Multiple sclerosis
Focal dystonia
Parkinson's disease