NF-1 is a progressive and diverse condition, making the prognosis difficult to predict. The NF-1 gene mutations manifest the disorder differently even amongst people of the same family. This phenomenon is called variable expressivity. For example, some individuals have no symptoms, while others may have a manifestation that is rapidly more progressive and severe. For many NF-1 patients, a primary concern is the disfigurement caused by cutaneous/dermal neurofibromas, pigmented lesions, and the occasional limb abnormalities. However, there are many more severe complications caused by NF-1 like increased cancer risk, a plexiform neurofibroma has a 10-15% chance of developing into a MPNST (Malignant Peripheral Nerve Sheath Tumour) . Many NF patients live perfectly normal and uninterrupted lives.
types of Neurofibromatosis
symptom of Neurofibromatosis
symptom of Lesch–Nyhan syndrome
symptom of Kabuki syndrome
symptom of Tay–Sachs disease
symptom of Laron syndrome
symptoms of Jervell and Lange-Nielsen syndrome
complications of Xeroderma pigmentosum