There is no known cause for this disease; however, three origins of AGL are generally suspected: panniculitis-associated, autoimmune-associated, and idiopathic AGLs. Triggers may include infections that aggravate the panniculitis, or any disease state that can induce autoimmunity. Overlap between panniculitis and autoimmune types also exists. Another theory suggest that AGL is an autoimmune disease itself, as panniculitis can be described as an autoimmune disease, however its triggering factors remains to be unknown. Underlying genetic factor may be associated; however neither confirmed nor rejected. Panniculitis-associated AGL About 25% of previously reported AGL is associated with panniculitis. Panniculitis is an inflammatory nodules of the subcutaneous fat, and in this type of AGL, adipose destruction originates locally at the infection or inflammation site and develops into generalized lipodystrophy. Autoimmune-associated AGL AGL with autoimmune origin is responsible for about 25% of all AGL reports. Those with autoimmune origin stems from other autoimmune diseases, most commonly with juvenile dermatomyositis and autoimmune hepatitis, but also occurs with rheumatoid arthritis, systemic lupus erythematosus, and Sjogren syndrome. Idiopathic AGL Although idiopathic AGL accounts for about 50% of all AGL, it can vary in its origin and its is unclear how it develops. No known preventive measurement has been reported.
Acquired generalized lipodystrophy
Drug-induced lipodystrophy
Involutional lipoatrophy
Congenital generalized lipodystrophy
Familial partial lipodystrophy
Lipoatrophic diabetes
Oral galvanism
HIV-associated lipodystrophy