<unk>  is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial DNA, thereby inhibiting cell division.<unk>  does not bind to DNA gyrase but does bind to the substrate DNA. A review in 2001 suggests that cytotoxicity of fluoroquinolones is likely a 2-step process involving (1) conversion of the topoisomerase-quinolone-DNA complex to an irreversible form and (2) generation of a double-strand break by denaturation of the topoisomerase.
Norfloxacin
Ofloxacin
Sparfloxacin
Enrofloxacin
Ciprofloxacin
Meropenem
Metronidazole
Cethromycin