<unk>  <unk> , also known as high affinity nerve growth factor<unk> , neurotrophic tyrosine kinase<unk>  type 1, or TRK1-transforming tyrosine kinase protein is a protein that in humans is encoded by the NTRK1 gene. This gene encodes a member of the neurotrophic tyrosine kinase<unk>  (NTKR) family. This kinase is a membrane-bound<unk>  that, upon neurotrophin binding, phosphorylates itself (autophosphorylation) and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain with anhidrosis, self-mutilating behaviors, intellectual disability and/or cognitive impairment and certain cancers. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Tropomyosin receptor kinase A
Thromboxane receptor
Prostaglandin-endoperoxide synthase 2
Phosphorylase kinase, alpha 1
Norepinephrine transporter
G protein-coupled receptor kinase 3
Angiotensin-converting enzyme 2
Beta-secretase 1