Classification The most widely accepted clinical classification of<unk>  was published by M. Michael Cohen in 1993. Cohen divided the syndrome into three possibly overlapping types, all of which are characterized by broad thumbs, broad great toes, brachydactyly and possibly syndactyly: * Type 1, also known as classic<unk> , includes craniosynostosis and "midface deficiency". This type is inherited in an autosomal dominant pattern. Most individuals with type 1<unk>  have normal intelligence and a normal life span. * Type 2 includes a cloverleaf-shaped skull, due to extensive fusion of bones, as well as severe proptosis. This type occurs sporadically (i.e., does not appear to be inherited) and has "a poor prognosis and severe neurological compromise, generally with early death". * Type 3 includes craniosynostosis and severe proptosis. This type occurs sporadically (i.e., does not appear to be inherited) and has "a poor prognosis and severe neurological compromise, generally with early death."
Pfeiffer syndrome
Zechi-Ceide syndrome
Johanson–Blizzard syndrome
Gómez–López-Hernández syndrome
Sanjad-Sakati syndrome
Adams–Nance syndrome
Lucey–Driscoll syndrome
Twiddler's syndrome