Mutations in the ASL gene cause<unk> .<unk>  belongs to a class of genetic diseases called urea cycle disorders. The urea cycle is a sequence of reactions in the cells of the liver. It processes excess nitrogen, generated when protein is used by the body, to make a compound called urea that is excreted by the kidneys. In<unk> , the enzyme argininosuccinate lyase, involved in the conversion of arginino succinate to arginine within the urea cycle, is damaged or missing. The urea cycle cannot proceed normally, and nitrogen accumulates in the bloodstream in the form of ammonia.Ammonia is especially damaging to the nervous system, so<unk>  causes neurological problems as well as eventual damage to the liver. This condition is inherited in an autosomal recessive pattern, which means two copies of the gene in each cell are altered. Most often, the parents of an individual with an autosomal recessive disorder are carriers of one copy of the altered gene but do not show signs and symptoms of the disorder.
Argininosuccinic aciduria
Homocystinuria
Phenylketonuria
2-Hydroxyglutaric aciduria
Hawkinsinuria
3-Methylglutaconic aciduria
Aspartylglucosaminuria
Urocanic aciduria