Prior to modern cardiovascular surgical techniques and medications such as losartan, and metoprolol, the prognosis of those with<unk>  was not good: a range of untreatable cardiovascular issues was common. Lifespan was reduced by at least a third, and many died in their teens and twenties due to cardiovascular problems. Today, cardiovascular symptoms of<unk>  are still the most significant issues in diagnosis and management of the disease, but adequate prophylactic monitoring and prophylactic therapy offers something approaching a normal lifespan, and more manifestations of the disease are being discovered as more patients live longer. Women with<unk>  live longer than men.
Marfan syndrome
Ehlers–Danlos syndromes
Marfanoid
Loeys–Dietz syndrome
Andersen–Tawil syndrome
Laron syndrome
XYY syndrome
Flynn–Aird syndrome