<unk>  is an aminocoumarin.<unk>  may be divided up into three entities; a benzoic acid derivative, a coumarin residue, and the sugar novobiose. X-ray crystallographic studies have found that the drug-receptor complex of<unk>  and DNA Gyrase shows that ATP and<unk>  have overlapping binding sites on the gyrase molecule. The overlap of the coumarin and ATP-binding sites is consistent with aminocoumarins being competitive inhibitors of the ATPase activity. Structure–activity relationship In structure activity relationship experiments it was found that removal of the carbamoyl group located on the novobiose sugar lead to a dramatic decrease in inhibitory activity of<unk> .
Novobiocin
Domoic acid
Hepatotoxin
Kaliotoxin
Psalmotoxin
Grammotoxin
Transfluthrin
Hemotoxin