Food, in particular fat, enhances the absorption of both<unk>  and<unk> , and patients are advised to take the tablets with food as soon as a meal can be tolerated. Coartem has a potential to prolong the QT interval, so combinations with other drugs having that property can cause irregular heartbeat, potentially leading to lethal ventricular fibrillation. The combination with halofantrine, another antimalarial, can cause a life-threatening QT prolongation. Drugs and other substances influencing the activity of the liver enzyme CYP3A4, including grapefruit juice, can either increase or lower blood levels of<unk> , depending on the sort of substance. This can either lead to more severe side effects or to reduced efficiency.
Artemether/lumefantrine
Artesunate/amodiaquine
Artesunate/mefloquine
Piperaquine/dihydroartemisinin
Artesunate/pyronaridine
Nifurtimox/eflornithine
Avermectin
Artesunate