In 2015 the first consensus guidelines for the diagnosis and treatment of<unk>  were published in The Lancet Oncology. These tumors express brachyury, which can be detected by immunohistochemistry. Classification Micrograph showing a classical<unk>  with its typical features. H&E stain. There are three histological variants of<unk> : classical (or "conventional"), chondroid and dedifferentiated. * The histological appearance of classical<unk>  is of a lobulated tumor composed of groups of cells separated by fibrous septa. The cells have small round nuclei and abundant vacuolated cytoplasm, sometimes described as physaliferous (having bubbles or vacuoles). * Chondroid<unk> s histologically show features of both<unk>  and chondrosarcoma.
Chordoma
Neurothekeoma
Brown tumor
Neuroma
Ependymoma
Germinoma
Ameloblastoma
Medulloblastoma