Nitrates and phosphodiesterase inhibitors (including PDE5 inhibitors) increase the hypotensive (blood pressure lowering) effect of<unk> . Combining such drugs is therefore contraindicated.<unk>  levels in the blood are reduced by tobacco smoking and strong inducers of the liver enzyme CYP3A4, and increased by strong cytochrome inhibitors.
Riociguat
Vericiguat
Sitaxentan
Cangrelor
Clemastine
Darusentan
Nafoxidine
Bosentan