Most cases of<unk>  show no symptoms. Infected organisms that show symptoms will range in severity depending on number of parasites. When the number of trematodes are high, signs of infection include severe pain in the abdomen. The signs and symptoms of the disease is also impacted by the location and spread of the parasite in the body. Tissues in organs are damaged when infected by the parasite. This damage can be mechanical as the parasite attaches to the walls of the host, as well as chemical. Symptoms of lung fluke infections (Paragonimus) depend on the parasite’s stage in its life cycle, and how it travels around in the lung.<unk>  that impacts the lungs can cause cough, headache, chest pain, high temperature and change in appetite. Intestinal<unk>  infect the gastrointestinal tract. Symptoms of intestinal fluke infections can range from mild to severe symptoms depending on the length of time that the parasite spends in the body. Signs and symptoms that arise in infected organisms include headache, indigestion problems such as diarrhoea, high temperature and pain in the abdomen which can also lead to malnutrition as the infected organism’s appetite is lost. In intestinal<unk> , the walls of the intestine can be damaged, which can lead to ulcers in some infected organisms.<unk>  caused by liver trematodes infect the host’s liver, gall bladder and bile duct and can cause inflammation within these organs. Symptoms vary from case to case and include abdominal pain, loss of appetite, problems with indigestion including diarrhoea and constipation, whereas in some cases, no symptoms are shown. O. viverrini damages the bile duct when in the adult stage of the life cycle, forming the cancer cholangiocarcinoma. Blood flukes can cause the<unk>  Schistosomiasis which can cause reactions on skin. When infected, the host can also experience symptoms such as nausea, lack of appetite, diarrhoea and abdominal pain.
Trematodiases
Acetylcholinesterase
Cathelicidin
Serpin
Streptokinase
Flavin-containing monooxygenase
Apamin
Pegaspargase