The gene encodes a protein - Tumor necrosis factor alpha-induced protein 3 - which inhibits the pro inflammatory actions of NF-κB. The protein encoded has both ubiquitin ligation deubiquitinase activities and forms part of the ubiquitin editing protein complex. It is involved in several biochemical pathways the details of which are still under investigation.
Haploinsufficiency of A20
Chromosome 2q deletion
Y chromosome microdeletion
Prenatal cocaine exposure
Mevalonate kinase deficiency
17β-Hydroxysteroid dehydrogenase III deficiency
WNT4 deficiency
Guanidinoacetate methyltransferase deficiency