Overdoses of<unk> , that is, taking more than the recommended maximum daily dose of<unk>  for healthy adults of three or four grams, can cause potentially fatal liver damage.<unk>  toxicity is the foremost cause of acute liver failure in the Western world, and accounts for most drug overdoses in the United States, the United Kingdom, Australia, and New Zealand.<unk>  overdose results in more calls to poison control centers in the US than overdose of any other pharmacological substance. According to the FDA, in the United States, "56,000 emergency room visits, 26,000 hospitalizations, and 458 deaths per year were related to acetaminophen-associated overdoses during the 1990s. Within these estimates, unintentional acetaminophen overdose accounted for nearly 25% of the emergency department visits, 10% of the hospitalizations, and 25% of the deaths." Overdoses are frequently related to high-dose recreational use of prescription opioids, as these opioids are most often combined with<unk> . The overdose risk may be heightened by frequent consumption of alcohol. Untreated<unk>  overdose results in a lengthy, painful illness. Signs and symptoms of<unk>  toxicity may initially be absent or non-specific symptoms. The first symptoms of overdose usually begin several hours after ingestion, with nausea, vomiting, sweating, and pain as acute liver failure starts. People who take overdoses of<unk>  do not fall asleep or lose consciousness, although most people who attempt suicide with<unk>  wrongly believe that they will be rendered unconscious by the drug. Treatment is aimed at removing the<unk>  from the body and replenishing glutathione. Activated charcoal can be used to decrease absorption of<unk>  if the person comes to the hospital soon after the overdose. While the antidote, acetylcysteine (also called N-acetylcysteine or NAC), acts as a precursor for glutathione, helping the body regenerate enough to prevent or at least decrease the possible damage to the liver; a liver transplant is often required if damage to the liver becomes severe. NAC was usually given following a treatment nomogram (one for people with risk factors, and one for those without), but the use of the nomogram is no longer recommended as evidence to support the use of risk factors was poor and inconsistent, and many of the risk factors are imprecise and difficult to determine with sufficient certainty in clinical practice. Toxicity of<unk>  is due to its quinone metabolite NAPQI and NAC also helps in neutralizing it. Kidney failure is also a possible side effect.
Paracetamol
Ketoprofen
Ibuprofen
Ketorolac
Meloxicam
Lornoxicam
Etodolac
Loxoprofen