Generic<unk>  HCl tablets marketed by Amneal Pharmaceuticals<unk>  HCl for injection Foil pack of 10 Utracet tablets<unk>  (a schedule IV drug in the US) is used primarily to treat mild to severe pain, both acute and chronic. There is moderate evidence for use as a second-line treatment for fibromyalgia but is not FDA approved for this use; however, its use is approved for treatment of fibromyalgia as a secondary painkiller by the NHS. Its analgesic effects take about one hour to come into effect and 2 to 4 h to peak after oral administration with an immediate-release formulation. On a dose-by-dose basis,<unk>  has about one-tenth the potency of morphine (thus 100 mg is commensurate with 10 mg morphine but may vary) and is practically equally potent when compared with pethidine and codeine. For pain moderate in severity, its effectiveness is equivalent to that of codeine at low doses, and hydrocodone at very high doses; for severe pain it is less effective than morphine. These painkilling effects last about 6 h. The potency of analgesia varies considerably as it depends on an individual's genetics. People with specific variants of CYP2D6 enzymes may not produce adequate amounts of the active metabolite (desmetramadol) for effective pain control. Sleep medicine physicians sometimes prescribe<unk>  (or other opiate medications) for refractory restless legs syndrome (RLS); that is, RLS that does not respond adequately to treatment with first-line medications such as dopamine agonists (like pramipexole) or alpha-2-delta (α2δ) ligands (gabapentinoids), often due to augmentation.
Tramadol
Tapentadol
Desmetramadol
Hydrocodone
Etodolac
Ketorolac
Oxycodone
Acetylmethadol