Luvox<unk>  100 mg film-coated scored tablets<unk>  inhibits the following cytochrome P450 enzymes: * CYP1A2 (strongly) which metabolizes agomelatine, amitriptyline, caffeine, clomipramine, clozapine, duloxetine, haloperidol, imipramine, phenacetin, tacrine, tamoxifen, theophylline, olanzapine, etc. * CYP3A4 (moderately) which metabolizes alprazolam, aripiprazole, clozapine, haloperidol, quetiapine, pimozide, ziprasidone, etc. * CYP2D6 (weakly) which metabolizes aripiprazole, chlorpromazine, clozapine, codeine, fluoxetine, haloperidol, olanzapine, oxycodone, paroxetine, perphenazine, pethidine, risperidone, sertraline, thioridazine, zuclopenthixol, etc. * CYP2C9 (moderately) which metabolizes nonsteroidal anti-inflammatory drugs, phenytoin, sulfonylureas, etc. * CYP2C19 (strongly) which metabolizes clonazepam, diazepam, phenytoin, etc. * CYP2B6 (weakly) which metabolizes bupropion, cyclophosphamide, sertraline, tamoxifen, valproate, etc. By so doing,<unk>  can increase serum concentration of the substrates of these enzymes. The plasma levels of oxidatively metabolized benzodiazepines (e.g., triazolam, midazolam, alprazolam and diazepam) are likely to be increased when co-administered with<unk> . However the clearance of benzodiazepines metabolized by glucuronidation (e.g., lorazepam, oxazepam, temazepam) is unlikely to be affected by<unk> . It appears that benzodiazepines metabolized by nitro-reduction (clonazepam, nitrazepam) are unlikely to be affected by<unk> . Using<unk>  and alprazolam together can increase alprazolam plasma concentrations. If alprazolam is coadministered with<unk> , the initial alprazolam dose should be reduced to the lowest effective dose.<unk>  and ramelteon coadministration is not indicated.<unk>  has been observed to increase serum concentrations of mirtazapine, which is mainly metabolized by CYP1A2, CYP2D6, and CYP3A4, by three- to four-fold in humans. Caution and adjustment of dosage as necessary are warranted when combining<unk>  and mirtazapine.<unk>  seriously affects the pharmacokinetics of tizanidine and increases the intensity and duration of its effects. Because of the potentially hazardous consequences, the concomitant use of tizanidine with<unk> , or other potent inhibitors of CYP1A2, should be avoided.<unk> 's interaction with St John's wort can lead to increased serotonin levels and potentially lead to serotonin syndrome.
Fluvoxamine
Medifoxamine
Phentermine
Gepirone
Pheniramine
Mephentermine
Doxepin
Sertindole