Photomicrographs of regions of substantia nigra in this Parkinson's patient show<unk> es and<unk>  neurites in various magnifications. Top panels show a 60× magnification of the alpha-synuclein intraneuronal inclusions aggregated to form<unk> es. The bottom panels are 20× magnification images that show strand-like<unk>  neurites and rounded<unk> es of various sizes. Neuromelanin-laden cells of the substantia nigra are visible in the background. Stains used: mouse monoclonal alpha-synuclein antibody; counterstained with Mayer's haematoxylin<unk> es<unk> es are the inclusion bodies – abnormal aggregations of protein – that develop inside nerve cells affected by Parkinson's disease (PD), the<unk>  dementias (Parkinson's disease dementia and dementia with<unk> es (DLB)), and some other disorders. They are also seen in cases of multiple system atrophy, particularly the parkinsonian variant (MSA-P).<unk> es appear as spherical masses in the cytoplasm that displace other cell components. For instance, some<unk> es tend to displace the nucleus to one side of the cell. There are two main kinds of<unk> es: classical and cortical.<unk> es may be found in the midbrain (within the substantia nigra) or within the cortex. A classical<unk>  is an eosinophilic cytoplasmic inclusion consisting of a dense core surrounded by a halo of 10-nm-wide radiating fibrils, the primary structural component of which is alpha-synuclein.
Lewy body
Neurofibrillary tangle
Kamino bodies
Hirano body
Alpha-synuclein
Verocay body
Downie bodies
Döhle bodies