Involvement of mast cells has been reported reflecting a possible immunoallergic aspect to IH. Mattingly suggests that IH may be an unusual variant of rheumatoid arthritis, and some patients may go on to develop RA. Joint damage however does not generally occur and only the synovial membrane is affected by a ‘non-inflammatory oedema’. With regard to the periodic nature of effusions, Reimann theorises that: “…either an inherent rhythm or a feedback mechanism (Morley, 1970) excites 'bioclocks' in the hypothalamus or in the synovial membrane (Richter, 1960). These 'Zeitgebers' provoke sudden accumulation of plasma in the lining and spaces of joints, tendon and ligament sheaths.”
Intermittent hydrarthrosis
Neuralgia-inducing cavitational osteonecrosis
Complications of prolonged standing
Progressive osseous heteroplasia
Repetitive strain injury
Microdamage in bone
Articular cartilage damage
Metastatic calcification