A simplified illustration demonstrates clot breakdown (fibrinolysis), with blue arrows denoting stimulation, and red arrows inhibition.<unk>  and plasmin are the key enzymes of the fibrinolytic pathway in which<unk> -mediated<unk> eration occurs. To be specific,<unk>  cleaves the zymogen<unk>  at its Arg561 - Val562 peptide bond, into the serine protease plasmin. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding and/or an increase of the vascular permeability. Decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. In ischemic stroke patients, decreased<unk>  activity was reported to be associated with an increase in plasma P-selectin concentration.<unk>  also plays a role in cell migration and<unk>  remodeling. Physiology and regulation 440x440px Once in the body,<unk>  has three main routes it can take, with one resulting in desired thrombolytic activity (see figure). For starters, following administration and release,<unk>  can be absorbed by the liver and cleared from the body through receptors present therein. One of the specific receptors responsible for this processes is a scavenger protein, specifically the LDL Receptor-Related Protein (LRP1).<unk>  additionally can be bound by a<unk><unk>  inhibitor (PAI), resulting in inactivation of its activity, and following clearing from the body by the liver. Lastly,<unk>  can bind<unk> , cleaving off the bound plasmin from it. Plasmin, another type of protease, can either be bound by a plasmin inhibitor, or work to degrade fibrin clots, which is the highest utilized and desired pathway. Synaptic plasticity<unk>  is known<unk> rticipate in some forms of synaptic plasticity, in particular long-term depression and consequently mediate some aspects of memory.
Tissue plasminogen activator
Argatroban
Lusutrombopag
Anistreplase
Bivalirudin
Heparin
Prothrombin complex concentrate
Palladin