Ten percent of patients present with splenomegaly and lymphadenopathy. Some patients report a varying degree of fatigue, consistent with a chronic fatigue syndrome, or postviral fatigue as seen in EBV infections while others remain asymptomatic.
Persistent polyclonal B-cell lymphocytosis
Chronic active EBV infection
Monoclonal B-cell lymphocytosis
Persistent generalized lymphadenopathy
Lymphoid neoplasms with plasmablastic differentiation
Thymoma-associated multiorgan autoimmunity
Progressive transformation of germinal centres
Immunodeficiency with hyperimmunoglobulin M