Known potential interactions of<unk>  are mostly the same as those of estradiol and include: * Cytochrome P450 inhibitors, especially of CYP3A4, can reduce the metabolism of estradiol and thereby increase estradiol levels; examples include anti-infectives (e.g., erythromycin, clarithromycin, ketoconazole, itraconazole), cimetidine, and grapefruit juice * Cytochrome P450 inducers, especially of CYP3A4, can induce the metabolism of estradiol and thereby decrease estradiol levels; examples include anticonvulsants (e.g., phenobarbital, carbamazepine, phenytoin), anti-infectives (rifampicin, rifabutin, nevirapine, and efavirenz), and St. John's wort; in addition, while ritonavir and nelfinavir are known as strong inhibitors, they have an inducing effect in combination with steroid hormones * Certain antibiotics (e.g., ampicillin, tetracyclines) may decrease estradiol levels by limiting enterohepatic recirculation of estradiol * Paracetamol (acetaminophen), certain beta blockers (e.g., metoprolol), and some benzodiazepines may increase the effects of<unk>  * The coagulation-promoting effects of<unk>  may enhance those of aminocaproic acid * Polystyrene phosphate can reduce the effects of anticoagulants * Estrogens increase thyroxine-binding globulin levels and may result in increased total thyroid hormone levels (but not free thyroid hormone levels in euthyroid individuals); interpretation of thyroid function tests should consider this * Due to reduced glucose tolerance, there may be an influence on need for insulin or oral antidiabetic medications *<unk>  may impair the effects of fibrates (e.g., bezafibrate) and certain nonsteroidal anti-inflammatory drugs (e.g., phenazone) * Concurrent use of hepatotoxic medications, especially dantrolene, may increase the risk of hepatotoxicity * Phosphatase inhibitors like levamisole may inhibit the cleavage of<unk>  into estradiol Interactions with<unk>  may be less than with oral estrogens due to the lack of the first-pass through the liver.
Polyestradiol phosphate
Polyestriol phosphate
Progestogen ester
Androgen ester
Progestogen 
Progestogen
Estradiol sulfate
Estrogen ester