<unk>  is a genetic disorder caused by the buildup of glycosaminoglycans (GAGs) in various organ tissues. It is a cutaneous condition, also characterized by mild mental retardation and corneal clouding. Respiratory problems, sleep apnea, and heart disease may develop in adolescence.<unk>  is classified as a lysosomal storage disease. Patients with<unk>  lack the ability to break down GAGs in their lysosomes due a deficiency of the enzyme iduronidase. All forms of mucopolysaccharidosis type I (MPS I) are a spectrum of the same disease. Hurler-Sheie is the subtype of MPS I with intermediate severity. Hurler syndrome is the most severe form, while<unk>  syndrome is the least severe form. Some clinicians consider the differences between Hurler, Hurler-Scheie, and<unk>  syndromes to be arbitrary. Instead, they classify these patients as having "severe", "intermediate", or "attenuated" MPS I.
Hurler–Scheie syndrome
Hunter syndrome
Gerstmann–Sträussler–Scheinker syndrome
Mucopolysaccharidosis type I
TORCH syndrome
Mucopolysaccharidosis
Gerstmann syndrome
Hurler syndrome