<unk>  causes a depression of the body's systems, mainly the central and peripheral nervous systems. Thus, the main characteristic of<unk>  overdose is a "slowing" of bodily functions, including decreased consciousness (even coma), bradycardia, bradypnea, hypothermia, and hypotension (in massive overdoses). Overdose may also lead to pulmonary edema and acute renal failure as a result of shock, and can result in death. The electroencephalogram (EEG) of a person with<unk>  overdose may show a marked decrease in electrical activity, to the point of mimicking brain death. This is due to profound depression of the central nervous system, and is usually reversible. Treatment of<unk>  overdose is supportive, and mainly consists of the maintenance of airway patency (through endotracheal intubation and mechanical ventilation), correction of bradycardia and hypotension (with intravenous fluids and vasopressors, if necessary), and removal of as much drug as possible from the body. In very large overdoses, multi-dose activated charcoal is a mainstay of treatment as the drug undergoes enterohepatic recirculation. Urine alkalization (achieved with sodium bicarbonate) enhances renal excretion. Hemodialysis is effective in removing<unk>  from the body, and may reduce its half-life by up to 90%. No specific antidote for barbiturate poisoning is available.
Phenobarbital
Methylphenobarbital
Phenytoin
Amobarbital
Heptobarbital
Mephenytoin
Galantamine
Levetiracetam