Its occurrence is very rare. The infantile form occurs from birth to 2 years of age. The average duration of the infantile form is usually about 3 years. Onset of the juvenile form presents between 2 and 12 years of age. Duration of this form is in most cases about 6 years. The adult form occurs after 12 years. In younger patients, seizures, megalencephaly, developmental delay, and spasticity are usually present. Neonatal onset is also reported. Onset in adults is least frequent. In older patients, bulbar or pseudobulbar symptoms and spasticity predominate. Symptoms of the adult form may also resemble multiple sclerosis. No more than 500 cases have been reported.
Alexander disease
Leber's hereditary optic neuropathy
Kjer's optic neuropathy
Corneal-cerebellar syndrome
Graves' ophthalmopathy
Neuromyelitis optica spectrum disorder
Ocular myasthenia
Bosch-Boonstra-Schaaf optic atrophy syndrome