Pharmacodynamics +<unk>  Site Ki (nM) Species Ref 890 Human 20,000 Human 52,000 Human 5-HT1A 85 Human 5-HT2A 36 Human 5-HT2C ? ? ? α1 38 Human α2 570 Human D2 2,300 Human H1 3,100 Human >35,000 Human Values are Ki (nM). The smaller the value, the more strongly the drug binds to the site.<unk>  is as an antagonist of several receptors in the following order of potency: 5-HT2A receptor (36 nM) > α1-adrenergic receptor (38 nM) > 5-HT1A receptor (85 nM) (may be a partial agonist) > α2-adrenergic receptor (570 nM); it has only very weak or negligible affinity for blocking the following receptors: D2 receptor (2,300 nM) > H1 receptor (3,100 nM) > mACh receptors (>35,000 nM). In addition to its receptor blockade,<unk>  also has weak affinity for the monoamine transporters as well: serotonin transporter (890 nM) > norepinephrine transporter (20,000 nM) > dopamine transporter (52,000 nM). Pharmacokinetics<unk>  is metabolized in part to meta-chlorophenylpiperazine (mCPP), which likely accounts for its serotonergic effects.
Etoperidone
Cinitapride
Iloperidone
Prucalopride
Bromopride
Domperidone
Pipotiazine
Palonosetron