Treatment consists of immunoglobulin replacement therapy, which replenishes Ig subtypes that the person lacks. This treatment is given at frequent intervals for life, and is thought to help reduce bacterial infections and boost immune function. Before therapy begins, plasma donations are tested for known blood-borne pathogens, then pooled and processed to obtain concentrated IgG samples. Infusions can be administered in three different forms: intravenously (IVIg), subcutaneously (SCIg), and intramuscularly (IMIg). The administration of intravenous immunoglobulins requires the insertion of a cannula or needle in a vein, usually in the arms or hands. Because highly concentrated product is used, IVIg infusions take place every 3 to 4 weeks. Subcutaneous infusions slowly release the Ig serum underneath the skin, again through a needle, and takes place every week. Intramuscular infusions are no longer widely used, as they can be painful and are more likely to cause reactions. People often experience adverse side effects to immunoglobulin infusions, including: * swelling at the insertion site<unk>  in SCIG) * chills * headache * nausea<unk>  in IVIG) * fatigue<unk>  in IVIG) * muscle aches and pain, or joint pain * fever<unk>  in IVIG and rare in SCIG) * hives (rare) * thrombotic events (rare) * aseptic meningitis (rare, more<unk>  in people with SLE) * anaphylactic shock (very rare) In addition to Ig replacement therapy, treatment may also involve immune suppressants, to control autoimmune symptoms of the disease, and high dose steroids like corticosteroids. In some cases, antibiotics are used to fight chronic lung disease resulting from<unk> . The outlook for people varies greatly depending on their level of lung and other organ damage prior to diagnosis and treatment.
Common variable immunodeficiency
Severe combined immunodeficiency
X-linked severe combined immunodeficiency
X-linked agammaglobulinemia
Chronic granulomatous disease
Primary immunodeficiency
Wiskott–Aldrich syndrome
Combined immunodeficiencies