The technique initially incubates a small amount of abnormal prion with an excess of normal<unk> , so that some conversion takes place. The growing chain of misfolded<unk>  is then blasted with ultrasound, breaking it down into smaller chains and so rapidly increasing the amount of abnormal<unk>  available to cause conversions. By repeating the cycle, the mass of normal<unk>  is rapidly changed into the prion being tested for.
Protein misfolding cyclic amplification
Molecular mimicry
Protein aggregation
Antigenic variation
Microbial synergy
Viral interference
Trinucleotide repeat expansion
Genetically modified virus