<unk>  <unk>  is a synthetic derivative of guanine. It is an antineoplastic agent. It exerts its effect by acting as a suicide inhibitor of the enzyme<unk> -alkylguanine-DNA alkyltransferase which leads to interruption of DNA repair.<unk>  was used clinically in combination with the alkylating agent temozolomide for glioblastoma, however the combination was found to be overly toxic without adding significant benefit.<unk>  is also used as a biochemical tool in the study of DNA repair mechanisms.
O6-Benzylguanine
Hemichrome
Methylphosphonyl difluoride
CccDNA
Stromagen
Corynanthine
Deoxygedunin
Fosdenopterin