<unk>  form as a natural part of the body’s healing process after surgery in a similar way that a scar forms. The term<unk> " is applied when the scar extends from within one tissue across to another, usually across a virtual space such as the peritoneal cavity.<unk> formation post-surgery typically occurs when two injured surfaces are close to one another. According to the "classical paradigm" of<unk> formation, the pathogenesis starts with inflammation and activation of the coagulation system which causes fibrin deposits onto the damaged tissues. The fibrin then connects the two adjacent structures where damage of the tissues occurred. The fibrin acts like a glue to seal the injury and builds the fledgling<unk>  said at this point to be "fibrinous." In body cavities such as the peritoneal, pericardial, and synovial cavities, a family of fibrinolytic enzymes may act to limit the extent of the initial fibrinous<unk>  and may even dissolve it. In many cases, the production or activity of these enzymes are compromised because of inflammation following injury or infection, however, and the fibrinous<unk> persists. A more recent study suggested that the formation of "fibrinous"<unk>  is preceded by the aggregation of cavity macrophages, that can act like extravascular platelets in the abdominal cavity. If this is allowed to happen, tissue repair cells such as macrophages, fibroblasts, and blood vessel cells penetrate into the fibrinous<unk> and lay down collagen and other matrix substances to form a permanent fibrous<unk>  In 2002, Giuseppe Martucciello's research group showed a possible role could be played by microscopic foreign bodies (FB) inadvertently contaminating the operative field during surgery. These data suggested that two different stimuli are necessary for<unk> formation: a direct lesion of the mesothelial layers and a solid substrate foreign body (FB). While some<unk>  do not cause problems, others may prevent muscle and other tissues and organs from moving freely, sometimes causing organs to become twisted or pulled from their normal positions.
Adhesion 
Subluxation
Disarticulation
Degranulation
UroVysion
Organ gifting
Friction
Effacement 