The syndrome is thought to arise from a mutation of several collagen genes during fetal development. It is a sex independent autosomal dominant trait meaning a person with the syndrome has a 50% chance of passing it on to each child. There are three variants of<unk>  identified, each associated with a collagen biosynthesis gene. A metabolic defect concerning the hyaluronic acid and the collagen of the 2-d type is assumed to be the cause of this syndrome.
Stickler syndrome
White Sutton syndrome
Hurler syndrome
Avellis syndrome
Sugarman syndrome
Setleis syndrome
Leschke syndrome
Noonan syndrome