The half-life varies in around 8 hours at normal doses. Excretion is 65% through urine, mostly in unmetabolized form, and 28% via feces. Clearance is reduced in people with severe kidney disease.<unk>  is more active (lower MIC90) than other quinolones against Gram-positive bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). In contrast to most approved fluoroquinolones, which are zwitterionic,<unk>  has an anionic character, which results in a 10-fold increase in<unk>  accumulation in both bacteria and cells at acidic pH. This property is believed to confer to<unk>  an advantage for the eradication of Staphylococcus aureus in acidic environments, including intracellular infections and biofilms.
Delafloxacin
Merafloxacin
Azithromycin
Gemifloxacin
Pefloxacin
Telithromycin
Dirithromycin
Roxithromycin