Acute symptoms of<unk>  poisoning by ingestion include vomiting, hematemesis (vomiting of blood), hypotension (low blood pressure), melena (black "tarry" feces), coma, jaundice (yellowish pigmentation of the skin), and gastrointestinal distress. Individuals with glucose-6-phosphate dehydrogenase deficiency may be at increased risk of hematologic effects of<unk> . Hemolytic anemia resulting from the treatment of burns with<unk>  compounds is infrequent. Chronic (long-term)<unk>  exposure can damage the liver and kidneys. Mammals have efficient mechanisms to regulate<unk>  stores such that they are generally protected from excess dietary<unk>  levels. Those same protection mechanisms can cause milder symptoms, which are often misdiagnosed as psychiatric disorders. There is a lot of research on the function of the Cu/Zn ratio in neurological, endocrinological, and psychological conditions. Many of the substances that protect us from excess<unk>  perform important functions in our neurological and endocrine systems, leading to diagnostic difficulties. When they are used to bind<unk>  in the plasma, to prevent it from being absorbed in the tissues, their own function may go unfulfilled. Such symptoms often include mood swings, irritability, depression, fatigue, excitation, difficulty focusing, and feeling out of control. To further complicate diagnosis, some symptoms of excess<unk>  are similar to those of a<unk>  deficit. The U.S. Environmental Protection Agency's Maximum Contaminant Level (MCL) in drinking water is 1.3 milligrams per liter. The MCL for<unk>  is based on the expectation that a lifetime of consuming<unk>  in water at this level is without adverse effect (gastrointestinal). The US EPA lists<unk>  as a micronutrient and a toxin. Toxicity in mammals includes a wide range of animals and effects such as liver cirrhosis, necrosis in kidneys and the brain, gastrointestinal distress, lesions, low blood pressure, and fetal mortality. The Occupational Safety and Health Administration (OSHA) has set a limit of 0.1 mg/m3 for<unk>  fumes (vapor generated from heating<unk>  and 1 mg/m3 for<unk>  dusts (fine metallic<unk>  particles) and mists (aerosol of soluble<unk>  in workroom air during an eight-hour work shift, 40-hour work week. Toxicity to other species of plants and animals is noted to varying levels. Toxicity<unk>  in the blood and blood stream exists in two forms: bound to ceruloplasmin (85–95%), and the rest "free", loosely bound to albumin and small molecules. Nutritionally, there is a distinct difference between organic and inorganic<unk> , according to whether the<unk>  ion is bound to an organic ligand. EPA cancer data The EPA lists no evidence for human cancer incidence connected with<unk> , and lists animal evidence linking<unk>  to cancer as "inadequate". Two studies in mice have shown no increased incidence of cancer. One of these used regular injections of<unk>  compounds, including cupric oxide. One study of two strains of mice fed<unk>  compounds found a varying increased incidence of reticulum cell sarcoma in males of one strain, but not the other (there was a slightly increased incidence in females of both strains). These results have not been repeated.
Copper toxicity
Zinc toxicity
Fluoride toxicity
Lead poisoning
Chromium toxicity
Boron deficiency 
Mercury poisoning
Metal toxicity