Immune complexes are thought to cause blood vessel damage, attracting neutrophils into the skin and synovium in BADAS. These antigen-antibody complexes are thought to be caused by excessive exposure to bacterial antigens (especially peptidoglycans). Bacterial overgrowth appears to be a frequent underlying condition. These antibodies possibly stimulate migration of neutrophils into the affected joints and skin. The effect of antibacterial therapy supports a role for bacteria in the disease mechanism (pathogenesis).
Bowel-associated dermatosis–arthritis syndrome
Mouth and genital ulcers with inflamed cartilage syndrome
Papular purpuric gloves and socks syndrome
Stevens–Johnson syndrome
Levamisole induced necrosis syndrome
Neuro-Behçet's disease
Acute cutaneous lupus erythematosus
Adult-onset Still's disease