<unk>  <unk>  is a rare, inherited metabolic disorder. Its prevalence in the United States population is approximately 1 newborn out of 180,000 live births. However, in populations where there is a higher frequency of consanguinity, such as the Mennonites in Pennsylvania or the Amish, the frequency of<unk>  is significantly higher at 1 newborn out of 176 live births. In Austria, 1 newborn out of 250,000 live births inherits<unk> . It also is believed to have a higher prevalence in certain populations due in part to the founder effect since<unk>  has a much higher prevalence in children of Amish, Mennonite, and Jewish descent.
Maple syrup urine disease
Urocanic aciduria
Alpha-aminoadipic and alpha-ketoadipic aciduria
Hawkinsinuria
3-Methylglutaconic aciduria
Homocystinuria
Alkaptonuria
2-Hydroxyglutaric aciduria