Use in the USA<unk>  was used in about 100 countries around the world to control insects in agricultural, residential, and commercial settings. Its use in residential applications is restricted in multiple countries. According to Dow,<unk>  is registered for use in nearly 100 countries and is annually applied to approximately 8.5 million crop acres. The crops with the most use include cotton, corn, almonds, and fruit trees, including oranges, bananas, and apples.<unk>  was first registered for use in the United States in 1965 for control of foliage and soil-born insects. The chemical became widely used in residential settings, on golf course turf, as a structural termite control agent, and in agriculture. Most residential use of<unk>  has been phased out in the United States; however, agricultural use remains common. EPA estimated that, between 1987 and 1998, about 21 million pounds of<unk>  were used annually in the US. In 2001,<unk>  ranked 15th among pesticides used in the United States, with an estimated 8 to 11 million pounds applied. In 2007, it ranked 14th among pesticide ingredients used in agriculture in the United States. Application<unk>  is normally supplied as a 23.5% or 50% liquid concentrate. The recommended concentration for direct-spray pin point application is 0.5% and for wide area application a 0.03–0.12% mix is recommended (US). Kinetics<unk>  enters the insect through several routes. Simon et al. 1998 report that insects encounter the active ingredient in their food plants and eat it. They also find it to enter through the digestive system, skin and membranes of the respiratory system. Mechanism of action Like other organophosphate pesticides<unk>  acts by acetylcholinesterase inhibition.
Chlorpyrifos
Diiodohydroxyquinoline
Parathion
Triphenylchloroethylene
Desmethylchlorotrianisene
Denatured alcohol
Dibenzofuran
Malathion