<unk>  belongs to the B7 family of the immunoglobulin superfamily. It is a 70 kDa glycoprotein made up of 329 amino acids. Both CD80 and<unk>  share a conserved amino acid motif that forms their ligand binding domain.<unk>  consists of Ig-like extracellular domains (one variable and one constant), a transmembrane region and a short cytoplasmic domain that is longer than that of CD80. costimulatory ligands CD80 and<unk>  can be found on professional antigen presenting cells such as monocytes, dendritic cells, and even activated B-cells. They can also be induced on other cell types, for example T cells.<unk>  expression is more abundant compared to CD80, and upon its activation is<unk>  increased faster than CD80. At the protein level,<unk>  shares 25% identity with CD80 and both are coded on human chromosome 3q13.33q21.
CD86
CD80
CD74
CD23
CD137
CD4
CD22
CD44