Pathway of tetrahydrofolate and antimetabolites<unk>  is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting three enzymes used in purine and pyrimidine synthesis—thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). By inhibiting the formation of precursor purine and pyrimidine nucleotides,<unk>  prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.
Pemetrexed
Nilotinib
Vincristine
Normustine
Gemcitabine
Epirubicin
Ifosfamide
Vinorelbine