Mechanism of action<unk>  is a viral terminase inhibitor. It specifically inhibits the CMV viral terminase complex which is encoded by the CMV genes UL56, UL51 and UL89. This inhibition has the effect of preventing cleavage of CMV DNA concatamers, resulting in long uncleaved DNA and noninfectious viral particles.<unk>  is only active against CMV and has no effect on other herpesviruses. Pharmacokinetics<unk>  is quickly absorbed from the gut, reaching its highest concentrations in the blood plasma after 1.5 to 3 hours. Its bioavailability is estimated to be 37%. Ciclosporin increases this bioavailability to about 85%. When in the bloodstream, the substance is almost completely (98.2%) bound to plasma proteins. It is mostly (96.6%) circulating in its original form; only a small proportion is metabolized by the liver enzymes UGT1A1 and UGT1A3, resulting in a glucuronide. The drug is mainly excreted via the faeces (93.3%). Less than 2% is found in the urine. The glucuronide which is the main metabolite of<unk>
Letermovir
Saquinavir
Entecavir
Fostemsavir
Coronavir
Lamivudine
Fosamprenavir
Abacavir