<unk>  also interacts with trimipramine and caffeine. Alcohol has an additive effect when combined with<unk> , enhancing the adverse effects including the overdose potential of<unk>  significantly. Due to these risks and the increased risk for dependence, alcohol should be avoided when using<unk> . Erythromycin appears to increase the absorption rate of<unk>  and prolong its elimination half-life, leading to increased plasma levels and more pronounced effects. Itraconazole has a similar effect on<unk>  pharmacokinetics as erythromycin. The elderly may be particularly sensitive to the erythromycin and itraconazole drug interaction with<unk> . Temporary dosage reduction during combined therapy may be required, especially in the elderly. Rifampicin causes a very notable reduction in half-life of<unk>  and peak plasma levels, which results in a large reduction in the hypnotic effect of<unk> . Phenytoin and carbamazepine may also provoke similar interactions. Ketoconazole and sulfaphenazole interfere with the metabolism of<unk> . Nefazodone impairs the metabolism of<unk>  leading to increased<unk>  levels and marked next-day sedation.
Zopiclone
Eszopiclone
Chloropicrin
Flumetasone
Budesonide
Clobetasone
Mibolerone
Fluticasone furoate