<unk> -Bücklers corneal<unk> , is a rare, corneal<unk>  of unknown cause, in which the Bowman's layer of the cornea undergoes disintegration. The disorder is inherited in an autosomal dominant fashion, and is associated with mutations in the gene TGFB1.<unk> -Bücklers<unk>  causes a cloudiness in the corneas of both eyes, which may occur as early as 1 year of age, but usually develops by 4 to 5 years of age. It is usually evident within the first decade of life. This cloudiness, or opacity, causes the corneal epithelium to become elevated, which leads to corneal opacities. The corneal erosions may prompt attacks of redness and swelling in the eye (ocular hyperemia), eye pain, and photophobia. Significant vision loss may occur.<unk> -Bücklers<unk>  is diagnosed by clinical history physical examination of the eye. Labs and imaging studies are not necessary. Treatment may include a complete or partial corneal transplant, or photorefractive keratectomy.
Reis–Bucklers corneal dystrophy
Lisch epithelial corneal dystrophy
Meesmann corneal dystrophy
Fleck corneal dystrophy
Schnyder crystalline corneal dystrophy
Blount's disease
Thygeson's superficial punctate keratopathy
Peyronie's disease