It is an autosomal recessive disorder in which mild clinical manifestations contrast with radiological appearances of gross<unk>  undermodeling. Most patients present with mild genu valgum. The elbows are unable to extend fully. There may be widening of the lower femora and clavicles. Bones can sometimes be fragile, but fracturing is usually not common. Patients may present with dental caries, mandibular prognathism, spinal alignment, and disproportionate limb lengthening. Mental development, physical development, and height are usually normal. Most patients with Pyle's diseases will have symptoms that vary from person to person. Symptoms are: 5%–29% of people have * Delated eruption of teeth Other people may have * Abnormality of thorax * Absent paranasal sinuses * Arthralgia * Carious teeth * Genu valgum * Hypoplastic frontal sinuses * Limited elbow extension * Mandibular prognathia *<unk>  widening *<unk>  * Muscle weakness * Platyspondyly * Reduced bone mineral density * Scoliosis * Thickened calvaria
Metaphyseal dysplasia
Multiple epiphyseal dysplasia
Achondroplasia
Otospondylomegaepiphyseal dysplasia
Craniodiaphyseal dysplasia
Cemento-osseous dysplasia
Spondylo-meta-epiphyseal dysplasia
Craniometaphyseal dysplasia