The condition is characterised by an increased proportion of lymphocytes in the epithelium of the duodenum, usually when this is greater than 20-25 per 100 enterocytes. Intra-epithelial lymphocyte (IEL) are normally present in intestine and numbers are normally greater in the crypts and in the jejunum; these are distinct from those found in the lamina propria of the intestinal mucosa. IELs are mostly T cells. Increased numbers of IELs are reported in around 3% of in<unk>  biopsies, depending on case mix, but may be increasingly being found, in up to 7%.
Duodenal lymphocytosis
Anti-gliadin antibodies
Generalized lymphadenopathy
Wandering spleen
Aberrant crypt foci
Black stomach
Pancreatic acinar metaplasia
Tonsil stones