Biopsy screening although necessary is not mandatory most dentist can visually examine the area and proceed with the proper course of treatment. Treatment includes: *Abstention from chewing areca nut (also known as betel nut) and tobacco *Minimizing consumption of spicy foods, including chiles *Maintaining proper<unk>  hygiene *Supplementing the diet with foods rich in vitamins A, B complex, and C and iron *Forgoing hot fluids like tea, coffee *Forgoing alcohol *Employing a dental surgeon to round off sharp teeth and extract third molars *Interprofessional treatment approach Treatment also includes following: *The prescription of chewable pellets of hydrocortisone (Efcorlin); one pellet to be chewed every three to four hours for three to four weeks *0.5 ml intralesional injection Hyaluronidase 1500 IU mixed in 1 ml of Lignocaine into each buccal mucosa once a week for 4 weeks or more as per condition *0.5 ml intralesional injection of Hyaluronidase 1500 IU and 0.5 ml of injection Hydrocortisone acetate 25 mg/ml in each buccal mucosa once a week alternatively for 4 weeks or more as per condition *Submucosal injections of hydrocortisone 100 mg once or twice daily depending upon the severity of the disease for two to three weeks *Submucosal injections of human chorionic gonadotrophins (Placentrax) 2-3 ml per sitting twice or thrice in a week for three to four weeks *Surgical treatment is recommended in cases of progressive<unk>  when interincisor distance becomes less than . (Multiple release incisions deep to mucosa,<unk> a and fibrotic tissue and suturing the gap or dehiscence so created by mucosal graft obtained from tongue and Z-plasty. In this procedure multiple deep z-shaped incisions are made into fibrotic tissue and then sutured in a straighter fashion.) *Pentoxifylline (Trental), a methylxanthine derivative that has vasodilating properties and increases mucosal vascularity, is also recommended as an adjunct therapy in the routine management of<unk> . * IFN-gamma is antifibrotic cytokine which alters collagen synthesis and helps in<unk> . *Colchicine tablets 0.5 mg twice a day *Lycopene, 16 mg a day helps in improvement of<unk>  The treatment of patients with<unk>  depends on the degree of clinical involvement. If the disease is detected at a very early stage, cessation of the habit is sufficient. Most patients with<unk>  present with moderate-to-severe disease. Severe<unk>  is irreversible. Moderate<unk>  is reversible with cessation of habit and mouth opening exercise. Current modern day medical treatments can make the mouth opening to normal minimum levels of 30 mm mouth opening with proper treatment.
Oral submucous fibrosis
Dyskeratosis congenita
Zenker's degeneration
Van Buchem disease
Degos disease
Bromoderma
Keratomalacia
Kyrle disease