One study found a correlation between the deletion of genes in a specific genetic region and the development of<unk>  in a group of Japanese patients. The region in question includes the SHC2 gene which, in mice and rats, appears to have some function in the nervous<unk> . The authors of this study hypothesized that there may be a link between the deletion of the SHC2 and the development of<unk> . A follow-up study was unable to replicate this finding in American<unk>  patients. The authors of the U.S. study concluded that "Our results indicate that SHC2 gene deletions underlie few, if any, cases of well-characterized<unk>  in the US population. This is in contrast to the Japanese experience reported by Sasaki et al., likely reflecting heterogeneity of the disease in different genetic backgrounds." Another study investigated the frequency of RFC1 intronic repeat expansions, a phenomenon implicated in CANVAS; a disease with a diagnostic overlap with<unk> . The study concluded that these repeats were absent in pathologically confirmed<unk> , suggesting an alternative genetic cause.
Multiple system atrophy
Pure autonomic failure
Progressive supranuclear palsy
Tropical ataxic neuropathy
Low pressure hydrocephalus
Spinal and bulbar muscular atrophy
Lewy body dementias
Amyotrophic lateral sclerosis