alt The<unk>  (S&S) is an<unk>  for predicting the splice sites, exons and genes in animals and plants. This<unk>  has the ability to discover disease-causing mutations in splice junctions in cancerous and non-cancerous diseases that is being used in major research institutions around the world. The S&S<unk>  has been cited in ~3,000 publications in clinical genomics on finding splicing mutations in thousands of diseases including many different forms of cancer and non-cancer diseases. It has been the basis of many leading software tools, such as Human Splicing Finder, Splice-site Analyzer Tool, dbass (Ensembl), Alamut and SROOGLE, which are cited by approx. 1,500 additional citations. The S&S<unk>  has thus significantly impacted the field of medicine, and is increasingly applied in today's disease research, pharmacogenomics, and Precision Medicine, as up to 50% of all diseases and ADRs (Adverse Drug Reactions) are now thought to be caused by RNA splicing mutations. Using the S&S<unk> , scientists have identified mutations and genes that cause numerous cancers, inherited disorders, immune deficiency diseases and neurological disorders. In addition, mutations in various drug metabolizing genes that cause ADRs to different drugs that are used to treat different diseases, including cancer chemotherapeutic drugs, have been identified. S&S is also used in detecting the “cryptic” splice sites that are not authentic sites used in the normal splicing of gene transcripts, and the mutations in which cause numerous diseases. The details are provided in the following sections.
Shapiro–Senapathy algorithm
Hamilton–Norwood scale
Mentzer index
SCORTEN scale
Haller index
ALS Functional Rating Scale - Revised
Eagle score
Glasgow-Blatchford score