CHAPLE syndrome is characterized by complement-mediated autoimmune hemolysis and paroxysmal nocturnal hemoglobinuria. The protein<unk>  (also called decay-accelerating factor) helps to regulate the complement cascade, part of the innate immune system, by regulating the amplification phase. When<unk>  is absent, the complement system attacks red blood cells and causes them to be destroyed (hemolysis).
CD55 deficiency
CD25 deficiency
MBL deficiency
Complement 2 deficiency
Complement 3 deficiency
Leukocyte adhesion molecule deficiency
Caspase-8 deficiency
CDKL5 deficiency disorder