Pharmacodynamics<unk>  is a μ-opioid receptor biased agonist developed by Trevena. In cell-based (in vitro) research,<unk>  elicits robust G protein signaling, with potency and efficacy similar to that of morphine, but with less β-arrestin 2 recruitment and receptor internalization. However, recent reports highlight that this might be due to its low intrinsic efficacy, rather than functional selectivity or 'G protein bias' as initially reported. In vivo, it may have fewer adverse effects (including respiratory depression and constipation) compared with morphine. In general, in vitro potency does not guarantee any clinical relevance in humans.
Oliceridine
Methitural
Pethidine
Aceclidine
Articaine
Lysergic acid diethylamide
Carctol
Eoxin