Dimethylaniline monooxygenase N-oxide-forming<unk>  is an enzyme that in humans is encoded by the<unk>  gene. Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in humans resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme,<unk>  found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the<unk> q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in xenobiotics such as pesticides and drugs.
Flavin containing monooxygenase 1
Flavin-containing monooxygenase 3
Flavin-containing monooxygenase
Aldehyde oxidase
Xanthine oxidase
Monoamine oxidase B
Alcohol sulfotransferase
Phenylalanine hydroxylase