The histiocytosis of Destombes–Rosai–Dorfman disease can occur in lymph nodes, causing lymphadenopathy, or can occur outside lymph nodes in extranodal disease. Lymphadenopathy Lymphadenopathy can occur in one or more groups of lymph nodes. Among 358 cases of Destombes–Rosai–Dorfman disease that<unk>  collected in a disease registry for which the location of lymphadenopathy was specified, 87.3% had cervical lymphadenopathy. Axillary, inguinal, and mediastinal lymphadenopathy are also found in Destombes–Rosai–Dorfman disease. Extranodal disease Accumulation of histiocytes may occur outside of lymph nodes. The most common sites of extranodal disease in<unk> 's registry were skin, nasal cavity/paranasal sinuses, soft tissue, eyelid/orbit, bone, salivary glands, central nervous system, and heart. The symptoms of this disease vary with the site of accumulation similar to other regional tumors. For instance, accumulation in closed spaces such as the cranium can lead to poor outcomes compared to growth in the dermis of an extremity where surgical excision is possible.
Rosai–Dorfman disease
Mowat–Wilson syndrome
Akureyri disease
Wilson–Mikity syndrome
Wilson's disease
BENTA disease
Batten disease
Keshan disease