Common * Nauseas * Change in taste * Vomiting * Diarrhea * Rashes * Sun sensitivity * Itchiness Rare * Can cause thrombocytopenia (low levels of platelets) by lowering folic acid levels; this may also cause megaloblastic anemia. *<unk>  antagonizes the epithelial sodium channel in the distal tubule, thus acting like amiloride. This can cause increased potassium levels in the body (hyperkalemia). * Can compete with creatinine for secretion into the renal tubule. This can cause an artificial rise in the serum creatinine. * Use in EHEC infections may lead to an increase in expression of Shiga toxin. Contraindications * Known hypersensitivity to<unk>  * History of megaloblastic anemia due to folate deficiency Pregnancy Based on the studies that show that<unk>  crosses the placenta and can affect folate metabolism, there has been growing evidence of the risk of structural birth defects associated with<unk> , especially during the first trimester of pregnancy. It may be involved in a reaction similar to disulfiram when alcohol is consumed after it is used, in particular when used in combination with sulfamethoxazole. The trophoblasts in the early fetus are sensitive to changes in the folate cycle. A recent study has found a doubling in the risk of miscarriage in women exposed to<unk>  in the early pregnancy.
Trimethoprim
Sulfamethoxazole
Moxifloxacin
Enrofloxacin
Phenoxymethylpenicillin
Doxycycline
Tetracycline
Minocycline