First line treatment is immunosuppressive therapy. A weekly dosage of Methotrexate (with or without daily Prednisone) may induce partial or complete response in some patients while others may require Cyclosporine or Cyclophosphamide. Alemtuzumab has been investigated for use in treatment of refractory T-cell<unk> . Experimental data suggests that treatment with calcitrol (the active form of vitamin D) may be useful in treating T-cell LGL due to its ability to decrease pro-inflammatory cytokines.
Large granular lymphocytic leukemia
Hemophagocytic lymphohistiocytosis
Aggressive NK-cell leukemia
Mixed-phenotype acute leukemia
T-lymphoblastic leukemia/lymphoma
Atypical chronic myeloid leukemia
Diffuse infiltrative lymphocytosis syndrome
Adult T-cell leukemia/lymphoma