<unk>  is caused by one important factor: mutations in the LEMD3 gene (12q14), located on chromosome 12. Among the important aspects of<unk>  condition, genetically speaking are: Bone Cells :::::::::* LEMD3 (protein) referred also as MAN1, is an important protein in inner nuclear membrane. :::::::::* LEMD3 gene gives instructions for producing protein that controls signaling for transforming growth factor-beta. :::::::::* LEMD3 gene helps in the bone morphogenic protein pathway :::::::::* Both of the above pathways help grow new bone cells :::::::::* BMP and TGF-β pathways controls SMADs proteins, which then bind to DNA :::::::::* LEMD3 once mutated, causes a reduction of the protein, which in turn causes excess of the above two pathways.
Buschke–Ollendorff syndrome
Satoyoshi syndrome
Dejerine–Sottas disease
Nakajo syndrome
McGillivray syndrome
Nicolau–Balus syndrome
Currarino syndrome
Baggio–Yoshinari syndrome