Paroxysmal nocturnal hemoglobinuria Because<unk>  is a GPI-anchored protein, its expression is reduced in persons with mutations that reduce GPI levels such as those with paroxysmal nocturnal hemoglobinuria (PNH). In PNH disorder, red blood cells with very low levels of<unk>  and CD59 undergo complement-mediated hemolysis. Symptoms include low red blood cell count (anemia), fatigue, and episodes of dark colored urine and other complications. Infectious diseases<unk>  is used as a receptor by some coxsackieviruses and other enteroviruses. Recombinant soluble<unk> -Fc has been tested in mice as an anti-enterovirus therapy for heart damage; however, the human enterovirus that was tested binds much more strongly to human<unk>  than to mouse or rat<unk> . Echoviruses and coxsackie B viruses that use human<unk>  <unk>  as a receptor do not bind the rodent analogues of<unk> . and<unk> -Fc has yet to be tested in humans. Binding of<unk>  to human HIV-1 when the virons are budding from the surface of infected cells may protect HIV-1 from complement mediated lysis.
Decay-accelerating factor
Lupus anticoagulant
Therapeutic interfering particle
Precipitin
Fragment crystallizable region
Serpin
Haptocorrin
Autoantibody