<unk>  works, in part, as an alkylating agent and methylates guanine at the O-6 position (much like dacarbazine also does). Guanine is one of the four nucleotides that makes up DNA. The methylated DNA is prone to breakage, and RNA and protein synthesis is inhibited. Proliferating cancer cells need to replicate their DNA and undergo programmed cell death (apoptosis) in response to DNA strand breaks. Normal or non-proliferating cells are more apt to repair the DNA damage, but still some of the healthy cells will be damaged.<unk>  is metabolized in the liver to an azo-derivative and then further metabolized by the cytochrome P-450 system to an active azoxy-derivative.
Procarbazine
Hydroxycarbamide
Dacarbazine
Mesocarb
Mercaptopurine
Indolocarbazole
Busulfan
Ifosfamide