PTGC is treated by excisional biopsy and follow-up. It may occasionally recur and in a small proportion of patients has been reported to subsequently develop Hodgkin lymphoma (usually nodular lymphocyte predominant Hodgkin lymphoma).
Progressive transformation of germinal centres
Atypical localization of immature precursors
Persistent polyclonal B-cell lymphocytosis
Lymphoid neoplasms with plasmablastic differentiation
Progressive osseous heteroplasia
Chronic active EBV infection
Extramedullary hematopoiesis
In situ lymphoid neoplasia