<unk><unk>  usually is noticeable in infants, causing hypotonia and declining muscle tone with age. Seizures can occur in childhood, and children are especially susceptible to broken bones. During early childhood, SRS causes mild to profound intellectual disability; speech difficulties; problems with walking; osteoporosis; marfanoid habitus; and scoliosis, kyphosis, or both (kyphoscoliosis). Distinctive facial features include a cleft palate, facial asymmetry, and a prominent lower lip. Kidney problems may also occur, such as nephrocalcinosis and renal cysts.
Snyder–Robinson syndrome
Cerebral palsy
Nance–Horan syndrome
Prader–Willi syndrome
Shapiro syndrome
Rett syndrome
Zadik–Barak–Levin syndrome
Urban–Rogers–Meyer syndrome