Klebsiella pneumoniae, the bacterium in which<unk>  was first identified.<unk>  is an enzyme that makes bacteria resistant to a broad range of<unk> -lactam antibiotics. These include the antibiotics of the carbapenem family, which are a mainstay for the treatment of antibiotic-resistant bacterial infections. The gene for<unk>  is one member of a large gene family that encodes<unk><unk>  enzymes called carbapenemases. Bacteria that produce carbapenemases are often referred to in the<unk> s media as "superbugs" because infections caused by them are difficult to treat. Such bacteria are usually sensitive only to polymyxins and tigecycline.<unk>  was first detected in a Klebsiella pneumoniae isolate from a Swedish patient of Indian origin in 2008. It was later detected in bacteria in India, Pakistan, the United Kingdom, the United States, Canada, Japan, and Egypt. The most common bacteria that make this enzyme are gram-negative such as Escherichia coli and Klebsiella pneumoniae, but the gene for<unk>  can spread from one strain of bacteria to another by horizontal gene transfer.
New Delhi metallo-beta-lactamase 1
Penicillin-binding proteins
Staphylococcus aureus delta toxin
Vancomycin-resistant Enterococcus
Fluorescein-labeled proaerolysin
Toxic shock syndrome toxin
BeKm-1 toxin
Vancomycin-resistant Staphylococcus aureus