The histological and ultrastructural features of Ledderhose and Dupuytren's disease are the same, which supports the hypothesis that they have a common cause and pathogenesis. As with Dupuytren's disease, the root cause(s) of Ledderhose's disease are not yet understood. It has been noted that it is an inherited disease and of variable occurrence within families, i.e. the genes necessary for it may remain dormant for a generation or more and then surface in an individual, or be present in multiple individuals in the same generation with varying degree. There are certain identified risk factors. The disease is more commonly associated with - * A family history of the disease * Higher incidence in males * Palmar fibromatosis 10-65% of the time. * Peyronie's disease * Epilepsy patients * Diabetes mellitus There is also a suspected, although unproven, link between incidence and alcoholism, smoking, liver diseases, thyroid problems, and stressful work involving the feet.
Plantar fibromatosis
Morton's neuroma
Infantile digital fibromatosis
Heel pad syndrome
Median rhomboid glossitis
Linguatulosis
Tenosynovitis
Trapeziometacarpal osteoarthritis