<unk>  in the human body has a half-life of 18 days and is quickly exhausted, particularly when metabolic demands exceed intake. A derivative of<unk> ,<unk>  pyrophosphate (TPP), is a cofactor involved in the citric acid cycle, as well as connecting the breakdown of sugars with the citric acid cycle. The citric acid cycle is a central metabolic pathway involved in the regulation of carbohydrate, lipid, and amino acid metabolism, and its disruption due to<unk>  inhibits the production of many molecules including the neurotransmitters glutamic acid and GABA. Additionally,<unk>  may also be directly involved in neuromodulation.
Thiamine deficiency
Fluorine deficiency
Boron deficiency 
Selenium deficiency
Biotin deficiency
Chromium deficiency
Copper deficiency
Magnesium deficiency