The signs and symptoms of<unk>  range from mild to severe, and can vary amongst patients depending on the age of the individual when symptoms begin as well as the specific subtype of disease each person has. Symptoms can also vary amongst individuals within the same subtype, but it is known that the earlier a person shows symptoms, the more severe the disease tends to progress over time. Individuals who are diagnosed with early infantile<unk>  have symptoms which present just before or after birth and tend to be most severe. The most common symptoms include abnormal fluid build up, hepatosplenomegaly, enlarged heart, abnormal bone development, kidney disease that progressively worsens, coarse facial features, and a cherry red spot on the back of the eye. Those who are diagnosed with late infantile subtype have symptoms which are similar to early infantile, except that they present around 6 months of age and tend to be less severe. Additional symptoms in this subtype can include growth problems, hearing or vision problems, and seizures. Juvenile/adult subtype symptoms include impaired balance or coordination, dark red spots on the skin or angiokeratomas, vision loss, seizures, and muscle jerks or myoclonus. The symptoms of this subtype tend to be less severe than the first two subtypes, and typically start in adolescence, with the average age being 16 years of age. Molecular structure of the enzyme Cathepsin A. Molecular structure of the enzyme neuraminidase-1 (NEU1).
Galactosialidosis
Beta-mannosidosis
Alpha-mannosidosis
Hereditary fructose intolerance
Gangliosidosis
Sialidosis
Aspartylglucosaminuria
Essential fructosuria