<unk>  is a member of the azapirone chemical class, and consists of azaspirodecanedione and pyrimidinylpiperazine components linked together by a butyl chain. Analogues Structural analogues of<unk>  include other azapirones like gepirone, ipsapirone, perospirone, and tandospirone. Synthesis<unk>  synthesis: Alkylation of 1-(2-pyrimidyl)piperazine (1) with 3-chloro-1-cyanopropane (2, 4-chlorobutyronitrile) gives 3, which is reduced either by hydrogenation over Raney nickel catalyst, or with LAH. The resulting 1° amine (4) from the previous step is then reacted with 3,3-tetramethyleneglutaric anhydride (5, 8-Oxaspiro4.5decane-7,9-dione) in order to yield<unk>  (6).
Buspirone
Nabilone
Dapoxetine
Medazepam
Atomoxetine
Citalopram
Sulpiride
Phenazepam