<unk> , sold under the brand names Prozac and Sarafem among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used for the treatment of major depressive disorder, obsessive–compulsive disorder (OCD), bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. It is also approved for treatment of major depressive disorder in adolescents and children 8 years of age and over. It has also been used to treat premature ejaculation.<unk>  is taken by mouth. Common side effects include indigestion, trouble sleeping, sexual dysfunction, loss of appetite, dry mouth, and rash. Serious side effects include serotonin syndrome, mania, seizures, an increased risk of suicidal behavior in people under 25 years old, and an increased risk of bleeding. Antidepressant discontinuation syndrome is less likely to occur with<unk>  than with other antidepressants, but it still happens in many cases.<unk>  taken during pregnancy is associated with significant increase in congenital heart defects in the newborns. It has been suggested that<unk>  therapy may be continued during breastfeeding if it was used during pregnancy or if other antidepressants were ineffective.<unk>  was discovered by Eli Lilly and Company in 1972, and entered medical use in 1986. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. In 2019, it was the 20th most commonly prescribed medication in the United States, with more than 27million prescriptions. Lilly also markets<unk>  in a fixed-dose combination with olanzapine as olanzapine/fluoxetine (Symbyax).
Fluoxetine
Atomoxetine
Duloxetine
Dapoxetine
Edivoxetine
Vortioxetine
Bupropion
Citalopram