Embryonic<unk>  cells are capable of self-renewing and<unk> g to the desired fate depending on their position in the body.<unk>  cell homeostasis is maintained through epigenetic mechanisms that are highly dynamic in regulating the chromatin structure as well as specific gene transcription programs. Epigenetics has been used to refer to changes in gene expression, which are heritable through modifications not affecting the DNA sequence. The mammalian epigenome undergoes global remodeling during early<unk>  cell development that requires commitment of cells to be restricted to the desired lineage. There has been multiple evidence suggesting that the maintenance of the lineage commitment of<unk>  cells is controlled by epigenetic mechanisms such as DNA methylation, histone modifications and regulation of ATP-dependent remolding of chromatin structure. Based on the histone code hypothesis, distinct covalent histone modifications can lead to functionally distinct chromatin structures that influence the cell's fate. This regulation of chromatin through epigenetic modifications is a molecular mechanism that determines whether the cell continues to differentiate into the desired fate. A research study by Lee et al. examined the effects of epigenetic modifications on the chromatin structure and the modulation of these epigenetic markers during<unk>  cell<unk>  through in vitro<unk>  of murine embryonic<unk>  (ES) cells.
Epigenetics in stem-cell differentiation
Biological effects of radiation on the epigenome
Control of chromosome duplication
Primordial germ cell migration
Pyrimidine metabolism
Stimulus-triggered acquisition of pluripotency
Eutherian fetoembryonic defense system 
Epigenetics of neurodegenerative diseases