The diagnosis of MMPSI is based on seizure types, age of onset, and EEG findings. It is diagnosed when the aforementioned most closely match MMPSI, as opposed to other electroclinical syndromes or epileptic encephalopathies. Electroencephalogram EEG during seizures (ictal EEG) shows focal discharges that migrate. They can either migrate to a contiguous area of the brain, or migrate to a noncontiguous area of the same or opposite side of the brain. EEG between seizures (interictal EEG) shows increasing diffuse slowing of background activity, with a prevalence of slow waves often shifting from one hemisphere to the other. As seizures become more frequent, the interictal phase can no longer be identified.
Malignant migrating partial seizures in infancy
Childhood absence epilepsy
Benign familial neonatal seizures
Benign infantile epilepsy
Benign familial infantile epilepsy
Autosomal dominant nocturnal frontal lobe epilepsy
Generalized epilepsy with febrile seizures plus
Benign neonatal seizures