<unk>  refers to the necrosis of the<unk>  tissue of the hepatic lobule. The<unk>  zone of the lobule is most prone to metabolic toxins such as those generated in alcoholic hepatitis. In acetaminophen overdose, glutathione depletion occurs and the highly reactive NAPQI will bind to the liver cells causing<unk> .
Centrilobular necrosis
Piecemeal necrosis
Collagenous spherulosis
Liquefactive necrosis
Caseous necrosis
Toxic vacuolation
Feathery degeneration
Fat necrosis