Radiographically,<unk> s have a rounded cyst-like radiolucent area with a well-defined margin with 53% showing scalloped margins. They can have a multilocular (honeycomb or soap bubble) appearance. Histologically similar to brown tumour found in hyperparathyroidism. Biochemical investigation through serum calcium, to exclude hyperparathyroidism. Histology Unknown pathogenesis. Histology of<unk>  shows a lobulated mass composed of vascular connective tissue and multinucleated giant cells (osteoclasts). The giant cells may be diffusely located throughout the lesion or focally aggregate in the lesion, often clustered around hemorrhagic areas hemosiderin deposits. Lobules of the lesion can be separated by fibrous tissue or even thin layer of bone or osteoid that can be seen radiographically. Giant cells are thought to form in response to signals produced by fibroblasts and blood vessels or as a response to cytokines. Differential diagnosis *Odontogenic keratocyst *Ameloblastoma *Odontogenic myxoma *Hemangioma<unk>  odontogenic fibroma *Brown tumour of hyperparathyrodism *Cherubism *Aneurysmal bone cysts
Central giant-cell granuloma
Peripheral giant-cell granuloma
Annular elastolytic giant-cell granuloma
Plasma cell granuloma
Patch-type granuloma annulare
Fibrin ring granuloma
Eosinophilic granuloma
Necrobiotic xanthogranuloma