<unk>  typically results in death or development of life-threatening conditions by the age of ten, though life expectancy is variable, and is highly dependent on specific circumstances. On the other hand, the milder variants of the disorder seem not to have any effect on lifespan.
Canavan disease
Menkes disease
Akureyri disease
CADASIL
White dot syndromes
Keshan disease
Farber disease
Familial British dementia