The condition gradually improves over a period of time which can range from six months to several years in more severe cases. People with longer term and heavier substance use have caused damage to the nervous system, where, after cessation of the primary addictive substance, the opioid receptors may become favorable to any potential agonist. This places people with longer term and heavier substance use at risk of becoming addicted to any other agonist with very little use of the secondary agonist. Abstinence from all agonists, sometimes taking multiple years, is required for full recovery. Flumazenil was found to be more effective than placebo in reducing feelings of hostility and aggression in patients who had been free of benzodiazepines for 4 to 266 weeks. This may suggest a role for flumazenil in treating protracted benzodiazepine withdrawal symptoms. Acamprosate has been found to be effective in alleviating some of the<unk><unk>  withdrawal symptoms of alcohol withdrawal. Carbamazepine or trazodone may also be effective in the treatment of<unk><unk>  withdrawal<unk>  in regards to alcohol use. Cognitive behavioral therapy can also help the<unk><unk>  withdrawal<unk>  especially when cravings are a prominent feature.
Post-acute-withdrawal syndrome
Benzodiazepine withdrawal syndrome
Alcohol withdrawal syndrome
Nicotine withdrawal
Secondary poisoning
Drug withdrawal
Opioid withdrawal
Antidepressant discontinuation syndrome