<unk>  is an estrogen ester, specifically, an ester of<unk> , and acts as a prodrug of<unk>  in the body. It is described as a weak estrogen in comparison to estradiol valerate.<unk>  is used medically via oral and vaginal routes similarly. In<unk> , two of the hydroxyl groups of<unk> , those at the C16α and C17β positions, are esterified with succinic acid. As such, when adjusted for differences in molecular weight, a dose of 2 mg<unk>  is equivalent to 1.18 mg unconjugated<unk> . Unlike other estrogen esters, such as estradiol valerate,<unk>  is hydrolyzed almost not at all in the intestinal mucosa when taken orally, and in relation to this, is absorbed more slowly than is<unk> . Consequently, oral<unk>  is a longer-acting form of<unk>  than oral<unk> . Instead of in the gastrointestinal tract, oral<unk>  is cleaved into<unk>  mainly in the liver. After a single 8 mg oral dose of<unk> , maximum levels of circulating<unk>  of 40 pg/mL are attained within 12 hours, and this increases up to 80 pg/mL with continued daily administration.
Estriol succinate
Estradiol undecylate
Estradiol dienantate
Estradiol furoate
Estradiol valerate
Estriol tripropionate
Estradiol dipropionate
Estradiol enantate