<unk> , sold under the brand name Cosopt among others, is a medication used to treat high pressure inside the eye including glaucoma. It is a combination of<unk>  hydrochloride and<unk>  maleate. It may be used when a beta blocker, like<unk> , is not sufficient alone. It is used as an eye drop. Common side effects include eye discomfort, eye redness, taste changes, and blurry vision. Serious side effects may include allergic reactions and heart failure. Use is not recommended in those with asthma, a sulfonamide allergy, or a slow heart rate.<unk>  is a carbonic anhydrase inhibitor and<unk>  is a beta blocker. Both work by decreasing the amount of aqueous humor made by the eye. The combination was approved for medical use in the United States in 1998. It is available as a generic medication. In 2017, it was the 233rd most commonly prescribed medication in the United States, with more than two million prescriptions.
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