<unk>  has been given orally to ~2700 patients with chronic constipation in controlled clinical trials. The most frequently reported side effects are headache and gastrointestinal symptoms (abdominal pain, nausea or diarrhea). Such reactions occur predominantly at the start of therapy and usually disappear within a few days with continued treatment.
Prucalopride
Bromopride
Itopride
Cinitapride
Tasimelteon
Lorcaserin
Sibutramine
Palonosetron