Congenital * Congenital<unk>  is rare. There are two distinct types of genetic disorders: heterotaxy syndrome and isolated congenital<unk> . * polysplenia Acquired Acquired<unk>  occurs for several reasons: * Following splenectomy due to splenic rupture from trauma or because of tumor * After splenectomy with the goal of interfering with splenic function, as a treatment for diseases (e.g. idiopathic thrombocytopenic purpura, thalassemia, spherocytosis), in which the spleen's usual activity exacerbates the disease * After splenectomy with the goal of arresting the progression of cancers (Chronic lymphocytic leukemia, Hodgkin's disease (starting in the 1970s), non-Hodgkin lymphoma) * Due to underlying diseases that destroy the spleen (autosplenectomy), e.g. sickle-cell disease. * Celiac disease: unknown physiopathology. In a 1970 study, it was the second most common cause of abnormalities of red blood cells linked to hyposplenism, after surgical splenectomy.
Asplenia
Polysplenia
Hepatosplenomegaly
Pica 
Splenomegaly
Neutrophilia
Nipple pigmentation
Bisalbuminemia