The main function of protein C is its anticoagulant property as an inhibitor of coagulation factors V and VIII. A deficiency results in a loss of the normal cleaving of Factors Va and VIIIa. There are two main types of protein C mutations that lead to<unk> : * Type I: Quantitative defects of protein C (low production or short protein half life) * Type II: Qualitative defects, in which interaction with other molecules is abnormal. Defects in interaction with thrombomodulin, phospholipids, factors V/VIII and others have been described. The majority of people with<unk>  lack only one copy of the functioning genes, and are therefore heterozygous. Before 1999, only sixteen cases of homozygous<unk>  had been described (two abnormal copies of the gene, leading to absence of functioning protein C in the bloodstream). This may manifest itself as purpura fulminans in newborn babies.
Protein C deficiency
Activated protein C resistance
Factor VII deficiency
Protein S deficiency
COAT platelet defect
Factor XIII deficiency
Factor XII deficiency
Antithrombin III deficiency