As a medical term,<unk>  is a feeling of general discomfort, uneasiness, or pain, and often the first sign of an infection or other disease. The word has existed in French since at least the 12th century. The term is often used figuratively in other contexts, in addition to its meaning as a general state of angst or melancholy.
Malaise
Anxiety
Scrapie
Pain
Scabies
Depression (mood)
Cat bite
Death rattle