<unk>  is recommended for use in focal seizures and neuropathic pain.<unk>  is widely prescribed off-label in the US and UK, for example, for the treatment of non-neuropathic pain, anxiety disorders and bipolar disorder. Seizures<unk>  is approved for the treatment of focal seizures; however, it is not effective for generalized epilepsy. Neuropathic pain<unk>  is recommended as a first-line treatment for chronic neuropathic pain by various medical authorities. This is a general recommendation applicable to all neuropathic pain syndromes except for trigeminal neuralgia. In regard to the specific diagnoses, the best evidence exists for<unk>  treatment of postherpetic neuralgia and diabetic neuropathy.<unk>  is approved for the former indication in the US. In addition to these two neuropathies, European Federation of Neurological Societies guideline notes<unk>  effectiveness for central pain. A combination of<unk>  with an opioid or nortriptyline may work better than either drug alone. Overall,<unk>  shows moderate effectiveness for neuropathic pain. Only a minority of patients obtain meaningful relief. Out of 10 persons treated with<unk> , three to four benefit substantially as compared to one to two persons treated with placebo. Evidence finds little or no benefit and significant risk in those with chronic low back pain or sciatica.<unk>  is not effective in HIV-associated sensory neuropathy and neuropathic pain due to cancer. Anxiety There is a scarcity of research on the use of<unk>  for the treatment of anxiety disorders. In a controlled trial of breast cancer survivors with anxiety, and in a trial for social phobia,<unk>  significantly reduced anxiety levels. For panic disorder,<unk>  is ineffective. Conversely, some psychiatric textbooks see "a possible role for<unk>  in anxiety disorders, particularly social phobia and panic disorder" based on "case reports and double-blind studies" or state that controlled studies have not shown<unk>  to be very effective for psychiatric indications; "however, clinically it is effective". Sleep<unk>  is effective in treating sleep disorders such as insomnia and restless legs syndrome.<unk>  enhances slow-wave sleep in patients with primary insomnia. It also improves sleep quality by elevating sleep efficiency and decreasing spontaneous arousal. The results suggest that<unk>  may be beneficial in the treatment of primary insomnia. Drug dependence<unk>  is moderately effective in reducing the symptoms of alcohol withdrawal and associated craving. The evidence in favor of<unk>  is weak in the treatment of alcoholism: it does not contribute to the achievement of abstinence, and the data on the relapse of heavy drinking and percent of days abstinent do not robustly favor<unk> ; it only decreases the percent days of heavy drinking.<unk>  is ineffective in cocaine dependence and methamphetamine use, and it does not increase the rate of smoking cessation.<unk>  does not significantly reduce the symptoms of opiate withdrawal. There is insufficient evidence for its use in cannabis dependence. Other<unk>  is recommended as a first-line treatment of the acquired pendular nystagmus, torsional nystagmus, and infantile nystagmus; however, it does not work in periodic alternating nystagmus.<unk>  decreases the frequency of hot flashes in both menopausal women and patients with breast cancer. However, antidepressants have similar efficacy, and the treatment with estrogen more effectively prevents hot flashes.<unk>  reduces spasticity in multiple sclerosis and is prescribed as one of the first-line options. It is an established treatment of restless legs syndrome.<unk>  alleviates itching in kidney failure (uremic pruritus) and itching of other causes. It may be an option in essential or orthostatic tremor. Although the efficacy of<unk>  for insomnia has not been established, it does alleviate sleep disorder in patients with medical illness.<unk>  does not appear to provide benefit for bipolar disorder, complex regional pain syndrome, post-surgical pain, or tinnitus, or prevent episodic migraine in adults.
Gabapentin
Pregabalin
Ibuprofen
Imagabalin
Naproxen
Meclofenamic acid
Oxcarbazepine
Paracetamol