Mutation in the gene CAPN3, which encodes the protein calpain-3 (CAPN3), is the cause of<unk> . As of 2019, more than 480 CAPN3 mutations have been reported, some of which can be associated with severe or benign disease course. Usually, the disease follows an autosomal recessive inheritance pattern, requiring both CAPN3 alleles to be mutated for disease to occur. However, there can be CAPN3 mutations that follow an autosomal dominant inheritance pattern.
Calpainopathy
Complex regional pain syndrome
Median nerve palsy
Enthesopathy
Ulnar neuropathy
Sciatica
Carpal tunnel syndrome
Nerve compression syndrome