<unk>  causes a fatty yellow pigment (lipofuscin) to build up in cells underlying the macula. The retinal pigment epithelium also degenerates. Over time, the abnormal accumulation of this substance can damage the cells that are critical for clear central vision. As a result, people with this disorder often lose their central vision and may experience blurry or distorted vision, and loss is rarely symmetric. Scotomata appear, first with red light and then for green; finally, relative (or in more serious cases, absolute) scotomata occur with white light.<unk>  does not affect side (peripheral) vision or the ability to see at night. Researchers have described two forms of<unk>  with similar features. The early-onset form (known as Best disease) usually appears in childhood. The disease received its name from a German ophthalmologist Friedrich Best who defined a pedigree living with various stages of the disease in 1905. The onset of symptoms and the severity of vision loss vary widely. The adult-onset form begins later, usually in middle age, and tends to cause relatively mild vision loss. The two forms of<unk>  each have characteristic changes in the macula that can be detected during an eye examination. In the Best disease, the paraclinic evaluations such as fundus fluorescein angiography or indocyanine green angiography, along with baseline and final electrooculography (EOG) results, may shed the light on the progression of disease.
Vitelliform macular dystrophy
Occult macular dystrophy
Meesmann corneal dystrophy
Macular corneal dystrophy
Granular corneal dystrophy
Fleck corneal dystrophy
Infiltrative ophthalmopathy
Subepithelial mucinous corneal dystrophy