<unk>  patients show moderate T-cell lymphopenia, hypogammaglobulinemia, and elevated double negative CD4/CD8 T cells (DNTs). More studies are required to understand the discrepancy associated with many laboratory manifestations, including an impaired Th17 differentiation among patients.
STAT3 GOF
HL23V
Philadelphia chromosome
Tbx18 transduction
T790M
ABL 
Fusion gene
GcMAF