There is no curative treatment. The disease remains progressive and fatal. Patients are managed according to what areas of the body are affected at a particular time. Enzymes, amino acids, antioxidants and vitamins have been used. Also the following supplements may help: * CoQ10 has been helpful for some<unk>  patients. Nicotinamide has been used because complex l accepts electrons from NADH and ultimately transfers electrons to CoQ10. * Riboflavin has been reported to improve the function of a patient with complex l deficiency and the 3250T-C mutation. * The administration of L-arginine during the acute and interictal periods may represent a potential new therapy for this syndrome to reduce brain damage due to impairment of vasodilation in intracerebral arteries due to nitric oxide depletion.
MELAS syndrome
Bannayan–Riley–Ruvalcaba syndrome
Pashayan syndrome
Fitzsimmons–Guilbert syndrome
Teunissen–Cremers syndrome
Fryns-Aftimos syndrome
Abruzzo–Erickson syndrome
Berk–Tabatznik syndrome