The<unk>  are the spots between the inner and outer red circles.<unk>  are small, white or greyish/brown spots on the periphery of the iris in the human eye due to aggregation of connective tissue, a normal constituent of the iris stroma. The spots are named after the physician Thomas<unk> , who first described them in his 1924 M.D. thesis.<unk>  are a characteristic feature of the chromosomal disorder Down syndrome or trisomy 21. They occur in 35–78% of newborn infants with Down syndrome.<unk>  tend to be obscured by pigmentation of the anterior border layer of the iris in patients with darker irides. Hence, they are much more likely to occur in children with lightly pigmented eyes.<unk>  are more commonly found in Down syndrome patients of European descent than similarly affected children of Asian heritage.<unk>  comprise focal areas of iris stromal hyperplasia, surrounded by relative hypoplasia. Similar spots described by Krückmann and Wolfflin are found in individuals without Down syndrome. Termed Krückmann-Wolfflin bodies, these spots typically are less well defined, fewer in number and more peripherally located than the<unk>  of trisomy 21.
Brushfield spots
Elschnig spots
Forchheimer spots
Bier spots
Koplik's spots
Fordyce spots
Bitot's spots
Cotton wool spots