There is not a specific theory behind the etiology of the<unk> , however, according to many researchers and doctors, there is a commonly known theory hypothesized by Jonathan Cohen in 1970. Cohen studied interstitial fluid in six children undergoing treatment for<unk> s. He believed that the chemical composition of the fluid found in the bone cyst was similar to the chemical make-up in serum. Cohen theorized that the<unk>  occurs when interstitial fluids in cancellous bones quickly accumulate in one region from blockage. One of the other theories is that the cysts result from a disorder of the growth plate. Another is that the cysts result from problems with circulation that are caused by a developmental anomaly in the veins of the affected bone. The role trauma plays in the development of these cysts is unknown. Some speculate that repeated trauma puts the bone at risk for developing a bone cyst. This, however, has not been proven. Recently, some of these tumors have been found to contain cells that express the FUS-NFATC2 or EWSR1-NFATC2 fusion gene. (Fusion genes are formed from two previously independent genes that become united due to a chromosome translocation, deletion of some genetic material in a chromosome, or chromosomal inversion. These two fusion genes are described in FET gene family.) A recent study reported that the neoplastic cells in these cysts expressed a FUS-NFATC2 fusion gene in four and a EWSR1-NFATC2 fusion gene in two of nine test cases. It is suggested that the presence of these fusion genes indicates that SEC is a true neoplasm.
Unicameral bone cyst
Bone cyst
Peripheral ossifying fibroma
Aneurysmal bone cyst
Osteoid osteoma
Leri pleonosteosis
Osteoma cutis
Osteochondroma