<unk>  often occurs during chronic inflammation. Diseases that produce such a chronic inflammatory state: * Infections: tuberculosis, brucellosis, listeriosis, subacute bacterial endocarditis, syphilis, and other viral infections and many protozoal and rickettsial infections (e.g. kala azar, malaria, Rocky Mountain spotted fever). * Blood and immune causes: chronic neutropenia and myeloproliferative disorders. * Autoimmune diseases and vasculitis: systemic lupus erythematosus, rheumatoid arthritis and inflammatory bowel disease. * Malignancies: Hodgkin's disease and certain leukaemias, such as chronic myelomonocytic leukaemia (CMML) and monocytic leukemia. * Recovery phase of neutropenia or an acute infection. * Obesity (cf. Nagareddy et al. (2014), Cell Metabolism, Vol. 19, pp 821–835) * Miscellaneous causes: sarcoidosis and lipid storage disease. During these stages of extreme inflammation,<unk>  can damage tissues because it increases the activation of the immune response and prevents the inflammation from subsiding which is seen in cases where sepsis occurs.
Monocytosis
Neutropenia
Mastocytosis
Macrocytosis
Anisocytosis
Poikilocytosis
Plasmacytosis
Binucleated cells