Since<unk>  leads to heavy glycosuria (sometimes up to about 70 grams per day) it can lead to rapid weight loss and tiredness. The glucose acts as an osmotic diuretic (this effect is the cause of polyuria in diabetes) which can lead to dehydration. The increased amount of glucose in the urine can also worsen the infections already associated with diabetes, particularly urinary tract infections and thrush (candidiasis). Rarely, use of an SGLT2 drug, including<unk> , is associated with necrotizing fasciitis of the perineum, also called Fournier gangrene.<unk>  is also associated with hypotensive reactions. There are concerns it may increase the risk of diabetic ketoacidosis.<unk>  can cause dehydration, serious urinary tract infections and genital yeast infections. Elderly people, people with kidney problems, those with low blood pressure, and people on diuretics should be assessed for their volume status and kidney function. People with signs and symptoms of metabolic acidosis or ketoacidosis (acid buildup in the blood) should also be assessed.<unk>  can cause serious cases of necrotizing fasciitis of the perineum (Fournier gangrene) in people with diabetes and low blood sugar when combined with insulin. To lessen the risk of developing ketoacidosis (a serious condition in which the body produces high levels of blood acids called ketones) after surgery, the FDA has approved changes to the prescribing information for SGLT2 inhibitor diabetes medicines to recommend they be stopped temporarily before scheduled surgery. Canagliflozin,<unk> , and empagliflozin should each be stopped at least three days before, and ertugliflozin should be stopped at least four days before scheduled surgery. Symptoms of ketoacidosis include nausea, vomiting, abdominal pain, tiredness, and trouble breathing. Use is not recommended in patients with eGFR 2, though data from 2021 shows the reduction in the kidney failure risks in people with chronic kidney disease using<unk> .
Dapagliflozin
Canagliflozin
Linagliptin
Empagliflozin
Sotagliflozin
Liraglutide
Vildagliptin
Pioglitazone