Mechanism of action<unk>  prevents bacteria from growing by interfering with their protein synthesis. It binds to the 50S subunit of the bacterial ribosome, thus inhibiting translation of mRNA. Nucleic acid synthesis is not affected. Pharmacokinetics<unk>  is an acid-stable antibiotic, so it can be taken orally with no need of protection from gastric acids. It is readily absorbed, but absorption is greater on an empty stomach. Time to peak concentration (Tmax) in adults is 2.1 to 3.2 hours for oral dosage forms. Due to its high concentration in phagocytes,<unk>  is actively transported to the site of infection. During active phagocytosis, large concentrations are released. The concentration of<unk>  in the tissues can be over 50 times higher than in plasma due to ion trapping and its high lipid solubility.<unk> 's half-life allows a large single dose to be administered and yet maintain bacteriostatic levels in the infected tissue for several days. Following a single dose of 500 mg, the apparent terminal elimination half-life of<unk>  is 68 hours. Biliary excretion of<unk> , predominantly unchanged, is a major route of elimination. Over the course of a week, about 6% of the administered dose appears as an unchanged drug in urine.
Azithromycin
Dirithromycin
Telithromycin
Roxithromycin
Levofloxacin
Moxifloxacin
Amoxicillin
Gemifloxacin