A diagnosis is usually confirmed by monitoring absolute neutrophil (ANC) count three times per week for at least six weeks. The confirmation can be assisted with Lomb periodogram. During the condition, which lasts for three to six days and tends to occur approximately every three weeks (but can range from 14 to 36 days), the absolute neutrophil count (ANC) is less than 200-500 cells/microL (9/L), with increase of monocyte counts, and mild oscillations of other cells, including a mild anemia. Between cycles the neutrophil count mostly peaks at subnormal or normal values. Genetic testing is advised for mutations in the ELANE and other<unk>  related genes (like HAX1, G6PC3, GFI1 etc.) to differentiate it from other secondary causes and forms of<unk> . In some cases intervals and oscillations can be lower, making the ANC analysis insufficient, and since both disorders can have the same mutation variants in ELANE it is preferable to have both ANC and genetic analysis to confirm in the diagnosis whether it is severe congenital or<unk> .
Cyclic neutropenia
Febrile neutropenia
Agranulocytosis
Cytopenia
Autoimmune neutropenia
Lymphocytopenia
Leukopenia
Dyserythropoiesis