Organophosphorus pesticides like<unk>  inhibit esterase enzyme activity like choline esterase. These types of pesticides can also directly interact with the biochemical receptors of acetylcholine. Organophosphates in general poisons mammals and insects by phosphorylating the acetylcholinesterase enzyme at nerve endings resulting in loss of function of the enzyme. This allows the accumulation of the neurotransmitter acetylcholine in cholinergic neuroeffector junctions, skeletal myoneural junctions, and autonomic ganglia. This refers to the type of receptors of acetylcholine, the muscarinic and nicotinic effects respectively. Thus organophosphates also impairs nerve impulse transmission.<unk>  can be absorbed via ingestion, inhalation or penetration of the skin as it can be rapidly absorbed via mucous membranes. When<unk>  is absorbed, it will be distributed via the blood circulation and undergo hydrolytic degradation. This mainly happens in the liver or kidneys but in other tissues as well.<unk>  is excreted in different metabolites via the urine.
Disulfoton
Cyclopentolate
Pralatrexate
Afamelanotide
Romiplostim
Trimetrexate
Efgartigimod alfa
Donanemab