* Positive direct antiglobulin test (DAT) for antibodies developed between 24 hours and 28 days after cessation of transfusion * Positive elution test with alloantibodies present on the transfused red blood cells OR newly identified red blood cell alloantibodies in recipient serum.Antibody elution is the process of removing antibodies from the surface of red blood cells. Techniques include using heat, ultrasound, acids or organic solvents. No single method is best in all situations. In an elution test, the eluted antibodies are subsequently tested against a panel of reagent red blood cells of known phenotype. * Inadequate rise of post-transfusion hemoglobin level OR rapid fall in hemoglobin level back to pre-transfusion levels OR otherwise unexplained appearance of spherocytes. PROBABLE DIAGNOSIS * Newly identified red blood cell alloantibody demonstrated between 24 hours and 28 days after cessation of transfusion BUT incomplete laboratory evidence to meet definitive case definition criteria.
Delayed hemolytic transfusion reaction
Acute hemolytic transfusion reaction
Hypotensive transfusion reaction
Allergic transfusion reaction
Transfusion associated circulatory overload
Transfusion-dependent anemia
Febrile non-hemolytic transfusion reaction
Post-transfusion purpura