Drug Induced<unk>  overgrowth: * Fibrotic type: * Elevated CTGF (a.k.a. CCN2) which is a matricellular protein known to be reliable for fibrosis. * TGF-β increases drives CTGF/CCN2 (current molecular mechanisms unknown), but supports TGF-β as a therapeutic target. * CTGF is not down regulated in presence of inflammatory mediators (such as PGE2), unlike other tissues' fibroblasts (such as kidney) which have their CTGF levels down regulated by the same PGE2. * Inflammatory Type
Gingival enlargement
Periorbital hyperpigmentation
Oral pigmentation
Anismus
Photophthalmia
Breast atrophy
Anophthalmia
Clitoromegaly