<unk>  is a relatively poorly understood disease, although awareness of it is rising.<unk>  is a chronic, T helper type 2 (Th2)–associated inflammatory disease characterized by predominant and marked eosinophilic inflammation of the esophagus. At a tissue level,<unk>  is characterized by a dense infiltrate with white blood cells of the eosinophil type into the epithelial lining of the esophagus. This is thought to be an allergic reaction against ingested food, based on the important role eosinophils play in allergic reactions. The eosinophils are recruited into the tissue in response to local production of eotaxin-3 by IL-13 stimulated esophageal epithelial cells. Eosinophils are inflammatory cells that release a variety of chemical signals which inflame the surrounding esophageal tissue. This results in the signs and symptoms of pain, visible redness on endoscopy, and a natural history that may include stricturing.
Eosinophilic esophagitis
Gastroesophageal reflux disease
Herpes esophagitis
Coeliac disease
Lymphocytic esophagitis
Crohn's disease
Cytomegalovirus esophagitis
Eosinophilic granulomatosis with polyangiitis