The condition results from infection, injury (accident, surgery), hypoperfusion and hypermetabolism. The primary cause triggers an uncontrolled inflammatory response. Sepsis is the most common cause of<unk>  and may result in septic shock. In the absence of infection, a sepsis-like disorder is termed systemic inflammatory response syndrome (SIRS). Both SIRS and sepsis could ultimately progress to<unk> . However, in one-third of the patients no primary focus can be found.<unk>  is well established as the final stage of a continuum: SIRS + infection File:U+2192.svg sepsis File:U+2192.svg severe sepsis File:U+2192.svg<unk> . Currently, investigators are looking into genetic targets for possible gene therapy to prevent the progression to<unk> . Some authors have conjectured that the inactivation of the transcription factors NF-κB and AP-1 would be appropriate targets in preventing sepsis and SIRS. These two genes are pro-inflammatory. However, they are essential components of a normal healthy immune response, so there is risk of increasing vulnerability to infection, which can also cause clinical deterioration.
Multiple organ dysfunction syndrome
Cytokine release syndrome
Tumor lysis syndrome
Systemic inflammatory response syndrome
Macrophage activation syndrome
Decompression sickness
Pulmonary-renal syndrome
Culture-bound syndrome