Adverse effect incidence Very common (>10% incidence) adverse effects include: * Somnolence Common (1-10% incidence) adverse effects include: * Weight gain * Increased appetite * Extrapyramidal side effects (EPS; such as dystonia, akathisia, dyskinesia, muscle rigidity, parkinsonism) * Sedation * Dizziness * Dysgeusia * Oral hypoaesthesia * Increased alanine aminotransferase * Fatigue Uncommon (0.1-1% incidence) adverse effects include: * Hyperglycaemia — elevated blood glucose (sugar) * Syncope * Seizure * Dysarthria * sinus bradycardia * Bundle branch block * QTc interval prolongation (has a relatively low risk for causing QTc interval prolongation.) * sinus tachycardia * Orthostatic hypotension * Hypotension * Swollen tongue * Dysphagia (difficulty swallowing) * Glossodynia * Oral paraesthesia Rare (0.01-0.1% incidence) adverse effects include: * Neuroleptic malignant syndrome (Combination of fever, muscle stiffness, faster breathing, sweating, reduced consciousness, and sudden change in blood pressure and heart rate) * Tardive dyskinesia * Speech disturbance * Rhabdomyolysis * Angioedema * Blood dyscrasias such as agranulocytosis, leukopenia and neutropenia * Accommodation disorder * Pulmonary embolism * Gynaecomastia * Galactorrhoea Unknown incidence adverse effects * Allergic reaction * Restless legs syndrome * Nausea * Oral mucosal lesions (ulcerations, blistering and inflammation) * Salivary hypersecretion * Hyperprolactinaemia<unk>  seems to have a relatively low weight gain liability for an atypical antipsychotic (which are notorious for their metabolic side effects) and a 2013 meta-analysis found significantly less weight gain (SMD standard mean difference in weight gained in those on placebo vs. active drug: 0.23; 95% CI: 0.07-0.39) than, paliperidone (SMD: 0.38; 95% CI: 0.27-0.48), risperidone (SMD: 0.42; 95% CI: 0.33-0.50), quetiapine (SMD: 0.43; 95% CI: 0.34-0.53), sertindole (SMD: 0.53; 95% CI: 0.38-0.68), chlorpromazine (SMD: 0.55; 95% CI: 0.34-0.76), iloperidone (SMD: 0.62; 95% CI: 0.49-0.74), clozapine (SMD: 0.65; 95% CI: 0.31-0.99), zotepine (SMD: 0.71; 95% CI: 0.47-0.96) and olanzapine (SMD: 0.74; 95% CI: 0.67-0.81) and approximately (that is, no statistically significant difference at the p=0.05 level) as much as weight gain as aripiprazole (SMD: 0.17; 95% CI: 0.05-0.28), lurasidone (SMD: 0.10; 95% CI: –0.02-0.21), amisulpride (SMD: 0.20; 95% CI: 0.05-0.35), haloperidol (SMD: 0.09; 95% CI: 0.00-0.17) and ziprasidone (SMD: 0.10; 95% CI: –0.02-0.22). Its potential for elevating plasma prolactin levels seems relatively limited too according to this meta-analysis. This meta-analysis also found that<unk>  has approximately the same odds ratio (3.28; 95% CI: 1.37-6.69) for causing sedation compared to placebo-treated patients as olanzapine (3.34; 95% CI: 2.46-4.50) and haloperidol (2.76; 95% CI: 2.04-3.66) and a higher odds ratio (although not significantly) for sedation than aripiprazole (1.84; 95% CI: 1.05-3.05), paliperidone (1.40; 95% CI: 0.85-2.19) and amisulpride (1.42; 95% CI: 0.72 to 2.51) to name a few and is hence a mild-moderately sedating antipsychotic. The same meta-analysis suggested that<unk>  had a relatively high risk of extrapyramidal symptoms compared to other atypical antipsychotics but a lower risk than first-generation or typical antipsychotics. Discontinuation For all antipsychotics, the British National Formulary recommends a gradual dose reduction when discontinuing to avoid acute withdrawal syndrome or rapid relapse. Symptoms of withdrawal commonly include nausea, vomiting, and loss of appetite. Other symptoms may include restlessness, increased sweating, and trouble sleeping. Less commonly there may be a feeling of the world spinning, numbness, or muscle pains. Symptoms generally resolve after a short period of time. There is tentative evidence that discontinuation of antipsychotics can result in psychosis. It may also result in recurrence of the condition that is being treated. Rarely tardive dyskinesia can occur when the medication is stopped.
Asenapine
Sertraline
Aripiprazole
Mirtazapine
Loxapine
Amoxapine
Perlapine
Trimipramine