Common constitutional signs and symptoms of the<unk>  include fever, nausea, vomiting, feeling tired, generalized discomfort, loss of appetite, and irritability in infants and toddlers. Skin lesions frequently develop in the form of a rash of flat discolored spots and bumps which may be followed by vesicular sores with blisters on palms of the<unk> s, soles of the feet, buttocks, and sometimes on the lips. The rash is rarely itchy for children, but can be extremely itchy for adults. Painful facial ulcers, blisters, or lesions may also develop in or around the nose or<unk> .<unk>  usually resolves on its own after 7–10 days. Most cases of the<unk>  are relatively harmless, but complications including encephalitis, meningitis, and paralysis that mimics the neurological symptoms of polio can occur. Image:Characteristic rash of<unk> , on human<unk> s.Rash on palms of the<unk> s. File:Hand<unk><unk><unk>  Adult 36Years.Rash on<unk>  and feet of a 36-year-old man File:Hand<unk>  and<unk><unk>  on child feet.Rash on the soles of a child's feet
Hand, foot, and mouth disease
Cowpox
Progressive vaccinia
Chickenpox
Smallpox
Shingles
Sealpox
Mumps