Etiologies of<unk>  RTA may be divided into primary, isolated causes and secondary causes, or those related to another disease. Primary causes are frequently single gene hereditary disorders. Secondary disorders can be divided into familial disorders, acquired disorders, and those related to other clinical entities. Primary Disorders * Autosomal dominant * Autosomal Recessive with Ocular Abnormalities (caused by SLC4A4 mutation) * Sporadic of Infancy (possibly related to immaturity of NHE-3) Secondary Disorders Familial disorders * Cystinosis * Galactosemia * Glycogen storage disease (type I) * Hereditary fructose intolerance * Lowe syndrome * Tyrosinemia * Wilson's disease Acquired disorders * Amyloidosis * Multiple myeloma * Paroxysmal nocturnal hemoglobinuria * Toxins, such as HAART, ifosfamide, lead, and cadmium
Proximal renal tubular acidosis
Distal renal tubular acidosis
Renal tubular acidosis
Inborn errors of renal tubular transport
Isotonic hyponatremia
Cystinuria
Hypotonic hyponatremia
Primary hyperoxaluria