A<unk>  (SPRM) is an agent that acts on the<unk>  receptor (PR), the biological target of progestogens like<unk> . A characteristic that distinguishes such substances from full receptor agonists (e.g.,<unk> , progestins) and full antagonists (e.g., aglepristone) is that their action differs in different tissues, i.e. agonist in some tissues while antagonist in others. This mixed profile of action leads to stimulation or inhibition in tissue-specific manner, which further raises the possibility of dissociating undesirable adverse effects from the development of synthetic PR-modulator drug candidates.
Selective progesterone receptor modulator
Selective estrogen receptor modulator
Selective androgen receptor modulator
N-Terminal domain antiandrogen
Selective estrogen receptor degrader
Steroidal aromatase inhibitor
Antiprogestogen
Antiestrogen