<unk>  has four different subtypes,<unk>  Type I,<unk>  Type II,<unk>  Type III, and<unk>  Type IV.<unk>  type II <unk>  II) is the most frequent type of<unk> s. Type Symptoms Bone marrow morphology OMIM Gene Locus Type I<unk> N1) Moderate to severe macrocytic anemia (commonly in neonates as intrauterine growth retardation). Erythroid precursors with incompletely divided erythroid cells held together with thin chromatin bridges. Ia<unk> N1 15q15 Ib C15ORF41 15q14 Type II<unk> N2) Moderate anemia, splenomegaly, and hepatomegaly. Binucleate and rare multinucleate polychromatic erythroblasts. SEC23B 20p11.2 Type III<unk> N3) Mild anemia and retinal degeneration. Giant multinucleated erythroblasts. KIF23 15q21 Type IV<unk> N4) Severe anemia at birth. KLF1 19p13.13-p13.12
Congenital dyserythropoietic anemia
Congenital hypoplastic anemia
Hereditary elliptocytosis
Congenital hemolytic anemia
Hereditary spherocytosis
Paroxysmal nocturnal hemoglobinuria
Diamond–Blackfan anemia
Twin anemia-polycythemia sequence