<unk>  is a hereditary syndrome, inherited in an X-linked recessive manner. The AR gene, located in the X chromosome, contains a tract of CAG repeats within the region coding for the N-terminal domain. The number of repeats varies among individuals. Healthy males carry up to 34 repeats. From 35 to around 46 repeats, penetrance (the possibility that the individual manifests the disease) gradually increases, approaching a maximum value (full penetrance). Therefore, males bearing 35 to 46 CAG repeats are at intermediate but increasing risk for developing<unk> . Males bearing 47 or more repeats have nearly 100% risk of developing<unk> . Other, still unidentified genetic factors may also play a role in disease manifestation and symptoms’ severity. Genetic founder effects are likely to be responsible for the higher prevalence of<unk>  observed in certain geographic regions.
Spinal and bulbar muscular atrophy
Infantile progressive bulbar palsy
Ataxic cerebral palsy
Madras motor neuron disease
Multiple system atrophy
Spinal muscular atrophy
Spinal muscular atrophy with lower extremity predominance 1
Babinski–Nageotte syndrome