A sample<unk>  <unk> ; an average of 10 single<unk> s) is shown at the top, and sample miniature<unk> s (mEPPs) are shown at the bottom. Note the differences in the scales on the X- and Y-axes. Both are taken from recordings at the mouse neuromuscular junction.<unk> s <unk> s) are the voltages which cause depolarization of skeletal muscle fibers caused by neurotransmitters binding to the postsynaptic membrane in the neuromuscular junction. They are called "end<unk> s" because the postsynaptic terminals of muscle fibers have a large, saucer-like appearance. When an action potential reaches the axon terminal of a motor neuron, vesicles carrying neurotransmitters (mostly acetylcholine) are exocytosed and the contents are released into the neuromuscular junction. These neurotransmitters bind to receptors on the postsynaptic membrane and lead to its depolarization. In the absence of an action potential, acetylcholine vesicles spontaneously leak into the neuromuscular junction and cause very small depolarizations in the postsynaptic membrane. This small response (~0.4mV) is called a miniature<unk>  (MEPP) and is generated by one acetylcholine-containing vesicle. It represents the smallest possible depolarization which can be induced in a muscle.
End-plate potential
Threshold potential
Cardiac action potential
Dark adaptation threshold
Compound muscle action potential
Intermuscular coherence
Seizure threshold
Evoked potential