Long term use may result in blepharospasms, especially in women. Doses of 4 mg or more may cause anterograde amnesia. In rare cases, erythema annulare centrifugum skin lesions have resulted. Tolerance, dependence and withdrawal Abrupt or rapid discontinuation from<unk> , as with benzodiazepines, may result in the appearance of the benzodiazepine withdrawal syndrome, including rebound insomnia. Neuroleptic malignant syndrome, a rare event in benzodiazepine withdrawal, has been documented in a case of abrupt withdrawal from<unk> . This is particularly relevant given<unk> 's short half life relative to benzodiazepines such as diazepam resulting in a more rapid drug level decrease in blood plasma levels. In a study that compared the effectiveness of<unk> , alprazolam, and bromazepam for the treatment of generalized anxiety disorder, all three drugs retained their effectiveness over 2 weeks, but<unk>  became more effective from 2 weeks to 4 weeks. Administering .5 mg<unk>  twice daily did not induce cognitive deficits over 3 weeks when compared to placebo. When multiple doses of<unk> , or lorazepam, were administered to rat neurons, lorazepam caused downregulation of alpha-1 benzodiazepine binding sites (tolerance/dependence), while<unk>  caused an increase in alpha-2 benzodiazepine binding sites (reverse tolerance to anti-anxiety effects). Tolerance to the anticonvulsant effects of lorazepam was observed, but no significant tolerance to the anticonvulsant effects of<unk>  was observed.<unk>  therefore has a reduced liability to induce tolerance, and dependence, compared with classic benzodiazepines.<unk>  may represent a possible anxiolytic of choice with reduced liability to produce tolerance and dependence after long-term treatment of anxiety and stress syndromes.
Etizolam
Avanafil
Brinzolamide
Dorzolamide
Vardenafil
Brotizolam
Tadalafil
Travoprost