Gene The human<unk>  gene,<unk> , is located on the long, i.e, "q", arm of chromosome 5 at position q31.1 (notated as 5q31.1). This location is close to several immune modulating genes including interleukins 3, 5, and 9 and granulocyte-macrophage colony stimulating factor.<unk>  is conserved in zebrafish, chicken, rat, mouse, cow. dog, Rhesus monkey, and chimpanzee. Human<unk>  is composed of 4 exons, 3 introns, and ~8,000 base pairs. The gene has numerous single nucleotide variants as well as other variations, two of which (see Pathophysiology section) have been associated with human disease. Human<unk>  has several different transcriptional initiation sights and codes for a mRNA composed of 1,000 to 1,300 ribonucleotides. mRNA for<unk>  is highly expressed in liver tissue and expressed at far lower levels in a wide range of other tssues. Protein === The<unk>  protein consists of 133`amino acids Its structure is similar to that of the M23 family of metalloendopeptidases. Unlike this family of peptidases, however,<unk>  has not been found to possess enzymatic activity and does not appear to share any functions with M23 metalloendopeptidases. It is widely expressed in vascular tissues, smooth muscle cells, adipocytes, cerebral neurons, apical squamous epithelia, parathyroid tissues, the epithelial cells of sweat and sebaceous glands, Hassall bodies, and monocytes. The liver hepatocyte is considered to be the source of the<unk>  circulating in blood. However, its expression in these cells is extremely low or undetectable even though these cells express very high levels of<unk>  mRNA. This implies that hepatocytes secrete<unk>  almost immediately after they make it. Using very sensitive methods,<unk>  protein can also be detected at low levels in the endothelial cells of hepatic arteries and veins including central veins. Several cell types or tissues, e.g. osteoblasts, chondrocytes, cardiac tissue, gastrointestinal smooth muscle cells, and epithelial cells of some tissues normally do not express<unk>  but do so under a variety of disease conditions.
LECT2 amyloidosis
AA amyloidosis
AL amyloidosis
Secondary systemic amyloidosis
Anti-AQP4 disease
Sarcoglycanopathy
Hyaluronidase deficiency
Monoclonal gammopathy