“Absorption of<unk>  is rapid following single doses of 200 mg, 400 mg and 800 mg. At the respective doses, mean peak serum and plasma concentrations of 0.8, 1.5 and 2.4 μg/mL are attained approximately one hour after dosing. The effective half-life of<unk>  in serum and plasma is 3–4 hours. Steady-state concentrations of<unk>  will be attained within two days of dosing. Renal excretion occurs by both glomerular filtration and tubular secretion as evidenced by the high rate of renal clearance (approximately 275 mL/min). Within 24 hours of drug administration, 26 to 32% of the administered dose is recovered in the urine as<unk>  with an additional 5-8% being recovered in the urine as six active metabolites of lesser antimicrobial potency. Only a small percentage (less than 1%) of the dose is recovered thereafter. Fecal recovery accounts for another 30% of the administered dose. Two to three hours after a single 400-mg dose, urinary concentrations of 200 μg/mL or more are attained in the urine. In healthy volunteers, mean urinary concentrations of<unk>  remain above 30 μg/mL for at least 12 hours following a 400-mg dose. The urinary pH may affect the solubility of<unk> .<unk>  is least soluble at urinary pH of 7.5 with greater solubility occurring at pHs above and below this value. The serum protein binding of<unk>  is between 10 and 15%.” Quoting from the 2009 package insert for Noroxin. Biotransformation is via the liver and kidneys, with a half-life of 3–4 hours.
Norfloxacin
Ofloxacin
Sparfloxacin
Enrofloxacin
Ciprofloxacin
Meropenem
Metronidazole
Cethromycin