<unk>  describes different mutations in the same gene that can sometimes give rise to strikingly different phenotypes. E.g., certain loss-of-function mutations in the RET gene, which encodes a receptor tyrosine kinase, can cause dominantly inherited failure of development of colonic ganglia, leading to defective colonic motility and severe chronic constipation (Hirschsprung disease).
Phenotypic heterogeneity
Genetic heterogeneity
Allelic heterogeneity
Dynamic mutation
Antineoplastic resistance
Neurodiversity
Heteroplasmy
Genetic exceptionalism