<unk>  describes the ingestion of one of the drugs in the<unk>  class in quantities greater than are recommended or generally practiced. The most common symptoms of overdose include central nervous system (CNS) depression, impaired balance, ataxia, and slurred speech. Severe symptoms include coma and respiratory depression. Supportive care is the mainstay of treatment of<unk> . There is an antidote, flumazenil, but its use is controversial. Deaths from single-drug<unk> s occur infrequently, particularly after the point of hospital admission. However, combinations of high doses of<unk> s with alcohol, barbiturates, opioids or tricyclic antidepressants are particularly dangerous, and may lead to severe complications such as coma or death. In 2013,<unk> s were involved in 31% of the estimated 22,767 deaths from prescription drug overdose in the United States. The US Food and Drug Administration (FDA) has subsequently issued a black box warning regarding concurrent use of<unk> s and opioids.<unk> s are one of the most highly prescribed classes of drugs, and they are commonly used in self-poisoning. Over 10 years in the United Kingdom, 1512 fatal poisonings have been attributed to<unk> s with or without alcohol. Temazepam was shown to be more toxic than the majority of<unk> s. An Australian (1995) study found oxazepam less toxic and less sedative, and temazepam more toxic and more sedative, than most<unk> s in overdose.
Benzodiazepine overdose
Opioid overdose
Tricyclic antidepressant overdose
Cocaine intoxication
Nicotine withdrawal
Carbamate poisoning
Benzodiazepine withdrawal syndrome
Drug withdrawal