<unk>  is sometimes used as a method of suicide. It has a similar fatality index to that of benzodiazepine drugs, apart from temazepam, which is particularly toxic in overdose. Deaths have occurred from<unk>  overdose, alone or in combination with other drugs. Overdose of<unk>  may present with excessive sedation and depressed respiratory function that may progress to coma and possibly death.<unk>  combined with alcohol, opiates, or other central nervous system depressants may be even more likely to lead to fatal overdoses.<unk>  overdosage can be treated with the GABAA receptor benzodiazepine site antagonist flumazenil, which displaces<unk>  from its binding site, thereby rapidly reversing its effects. Serious effects on the heart may also occur from a<unk>  overdose when combined with piperazine. Death certificates show the number of<unk> -related deaths is on the rise. When taken alone, it usually is not fatal, but when mixed with alcohol or other drugs such as opioids, or in patients with respiratory, or hepatic disorders, the risk of a serious and fatal overdose increases.
Zopiclone
Eszopiclone
Chloropicrin
Flumetasone
Budesonide
Clobetasone
Mibolerone
Fluticasone furoate