No one knows what causes FAVA, though recent research revealed mutations in a gene called PIK3CA in some — but not all — cases. PIK3CA is a gene in the receptor tyrosine kinase phosphatidylinositol 3-kinase (PI3)-AKT growth-signaling pathway. The PIK3CA gene is located on the long (q) arm of chromosome 3. There has been no evidence to suggest that FAVA is inherited or passed along in families.
Fibro-adipose vascular anomaly
Connective tissue neoplasm
Gonadal tissue neoplasm
Iatrogenesis
Endocrine gland neoplasm
Vascular ring
Surgical stress
Vascular anomaly