Pharmacodynamics<unk>  elicits its effects by binding to and activating the μ-opioid receptor (MOR) and, to a much lesser extent, the δ-opioid receptor (DOR) and κ-opioid receptor (KOR). Its activity at the DOR may augment its action at the MOR.<unk>  is 10 times more potent than morphine. The calculation of relative potency indicated that 1 mg of<unk>  hydrochloride equaled 9.85 mg of morphine sulfate, or 1.02 mg of<unk>  hydrochloride was equivalent to 10 mg of morphine sulfate. +<unk>  at opioid receptors Affinities () Ratio MOR:DOR:KOR 0.78 nM 50 nM 137 nM 1:64:176 + Equianalgesic doses Compound Route Dose Codeine 200 mg Hydrocodone 20–30 mg Hydromorphone 7.5 mg Hydromorphone 1.5 mg Morphine 30 mg Oxycodone 20 mg Morphine 10 mg Oxycodone 20 mg<unk>  7–10 mg<unk>  1 mg Pharmacokinetics
Oxymorphone
Hydromorphone
Oxymorphol
Butorphanol
Morphine
Noroxycodone
Nalorphine
Oxycodone