<unk> , sold under the brand name Zoloft among others, is an antidepressant of the selective<unk> otonin reuptake inhibitor (SSRI) class. The efficacy of<unk>  for depression is similar to that of other antidepressants, and the differences are mostly confined to side effects.<unk>  is better tolerated than the older tricyclic antidepressants, and it may work better than fluoxetine for some subtypes of depression.<unk>  is effective for panic disorder, social anxiety disorder, generalized anxiety disorder, and obsessive–compulsive disorder (OCD). However, for OCD, cognitive behavioral therapy, particularly in combination with<unk> , is a better treatment. Although approved for post-traumatic stress disorder,<unk>  leads to only modest improvement in this condition.<unk>  also alleviates the symptoms of premenstrual dysphoric disorder and can be used in sub-therapeutic doses or intermittently for its treatment.<unk>  shares the common side effects and contraindications of other SSRIs, with high rates of nausea, diarrhea, insomnia, and sexual side effects, but it appears not to lead to much weight gain, and its effects on cognitive performance are mild. Similar to other antidepressants, the use of<unk>  for depression may be associated with a higher rate of suicidal thoughts and behavior in people under the age of 25. It should not be used together with MAO inhibitor medication: this combination causes<unk> otonin syndrome.<unk>  taken during pregnancy is associated with a significant increase in congenital heart defects in newborns.<unk>  was invented and developed by scientists at Pfizer and approved for medical use in the United States in 1991. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. In 2016,<unk>  was the most commonly prescribed psychiatric medication in the United States and in 2019, it was the twelfth most commonly prescribed medication in the United States, with over 37 million prescriptions.
Sertraline
Citalopram
Escitalopram
Clomipramine
Trimipramine
Mirtazapine
Asenapine
Quetiapine