<unk> (from Greek σκληρός sklērós, "hard") is the stiffening of a tissue or anatomical feature, usually caused by a replacement of the normal organ-specific tissue with connective tissue. The structure may be said to have undergone sclerotic changes or display sclerotic lesions, which refers to the process of<unk>  Common medical conditions whose pathology involves<unk> include: * Amyotrophic lateral<unk> also known as Lou Gehrig's disease or Motor neurone disease—a progressive, incurable, usually fatal disease of motor neurons. * Atherosclerosis, a deposit of fatty materials, such as cholesterol, in the arteries which causes hardening. * Focal segmental glomerulosclerosis is a disease that attacks the kidney's filtering system (glomeruli) causing serious scarring and thus a cause of nephrotic syndrome in children and adolescents, as well as an important cause of kidney failure in adults. * Hippocampal<unk>  a brain damage often seen in individuals with temporal lobe epilepsy. * Lichen<unk> , an autoimmune disease that hardens the connective tissues of the vagina and the penis. * Multiple<unk>  or focal<unk>  is a central nervous system disease which affects coordination. * Osteosclerosis, a condition where the bone density is significantly increased, resulting in decreased lucency on radiographs. * Otosclerosis, a disease of the ears. * Primary lateral<unk>  progressive muscle weakness in the voluntary muscles. * Primary<unk> g cholangitis, a hardening of the bile duct by scarring and repeated inflammation. * Systemic<unk> (progressive systemic scleroderma), a rare, chronic disease which affects the skin, and in some cases also blood vessels and internal organs. * Tuberous<unk>  a rare genetic disease which affects multiple systems.
Sclerosis 
Scalding
Hyperpigmentation
Calcification
Steatosis
Moist desquamation
Granulation
Neovascularization