<unk><unk>  hormone (FSH)<unk> , or ovarian<unk>  to FSH in females, also referable to as ovarian<unk>  hypoplasia or granulosa cell hypoplasia in females, is a rare autosomal recessive genetic and endocrine syndrome affecting both females and males, with the former presenting with much greater severity of symptomatology. It is characterized by a resistance or complete<unk>  to the effects of<unk><unk>  hormone (FSH), a gonadotropin which is normally responsible for the stimulation of estrogen production by the ovaries in females and maintenance of fertility in both sexes. The condition manifests itself as hypergonadotropic hypogonadism (decreased or lack of production of sex steroids by the gonads despite high circulating levels of gonadotropins), reduced or absent puberty (lack of development of secondary sexual characteristics, resulting in sexual infantilism if left untreated), amenorrhea (lack of menstruation), and infertility in females, whereas males present merely with varying degrees of infertility and associated symptoms (e.g., decreased sperm production). A related condition is luteinizing hormone (LH)<unk>  (termed Leydig cell hypoplasia when it occurs in males), which presents with similar symptoms to those of FSH<unk>  but with the symptoms in the respective sexes reversed (i.e., hypogonadism and sexual infantilism in males and merely problems with fertility in females); however, males also present with feminized or ambiguous genitalia (also known as pseudohermaphroditism), whereas ambiguous genitalia does not occur in females with FSH<unk> . Despite their similar causes, LH<unk>  is considerably more common in comparison to FSH<unk> .
Follicle-stimulating hormone insensitivity
Thyroid hormone resistance
Gonadotropin-releasing hormone insensitivity
Congenital adrenal hyperplasia
Lipoid congenital adrenal hyperplasia
Hypergonadotropic hypergonadism
Isolated growth hormone deficiency
Familial male-limited precocious puberty