PRSS1 The mechanism of<unk>  viewed from a genetic standpoint indicates early onset of severe epigastric pain beginning in childhood. It is an autosomal dominant disease,<unk>  disease is identified in the cationic trypsinogen gene PRSS1, and mutation, R122H. R122H is the most common mutation for hereditary<unk>  with replacement of arginine with histidine at amino acid position 122 of the trypsinogen protein. There are, of course, other mechanisms – alcohol, malnutrition, smoking – each exhibiting its own effect on the pancreas.
Chronic pancreatitis
Hereditary pancreatitis
Autoimmune pancreatitis
Periampullary cancer
Pancreatic abscess
Acute pancreatitis
Biliary pseudolithiasis
Gallstone ileus