<unk>  diagnosis usually begins due to a history of recurrent infections, mostly in the respiratory tract, through childhood. This is due to humoral immunodeficiency. The diagnosis is probable when blood tests show the complete lack of circulating B cells (determined by the B cell marker CD19 and/or CD20), as well as low levels of all antibody classes, including IgG, IgA, IgM, IgE and IgD. When<unk>  is suspected, it is possible to do a Western Blot test to determine whether the Btk protein is being expressed. Results of a genetic blood test confirm the diagnosis and will identify the specific Btk mutation, however its cost prohibits its use in routine screening for all pregnancies. Women with an<unk>  patient in their family should seek genetic counseling before pregnancy. Although the symptoms of a<unk>  and other primary immune diseases (PID) include repeated and often severe infections, the average time for a diagnosis of a PID can be up to 10 years.
X-linked agammaglobulinemia
Severe combined immunodeficiency
X-linked severe combined immunodeficiency
Common variable immunodeficiency
Combined immunodeficiencies
Primary immunodeficiency
Selective immunoglobulin A deficiency
Transient hypogammaglobulinemia of infancy