Symptoms for<unk>  generally appear during infancy with great variability in age. Some of the symptoms include: * Heart failure (dilated cardiomyopathy) in over 60% of cases, usually within the first few weeks after birth, but sometimes the onset is in adolescence or adulthood. * Light sensitivity and vision problems (cone-rod dystrophy) in all cases, usually within 15 months of birth and progressively worsening until about 20 years of age * Delays in early, developmental milestones in 50% of cases, learning disabilities in about 30% of cases * Obesity in 100% of cases, apparent by 5 years of age but often apparent in infancy<unk>  infants usually have normal birth weights, and by adolescence, weights tend to be in the high-normal to normal range.) * Nystagmus (usually affects the children), one of the first symptoms to occur which causes involuntary rapid eye movement. * Mild to moderate bilateral sensorineural hearing loss. * Type 2 diabetes usually occurs in early childhood. * Hyperinsulinemia/insulin resistance—development of high level of insulin in blood. * Hypertriglyceridemia * Steatosis (fatty liver) and elevated transaminases (liver enzymes) often develop in childhood and can progress in some patients to cirrhosis and liver failure. * Endocrine dysfunctions may occur where the patient may experience an under or over active thyroid gland, weak growth hormone, increased androgen in females and low testosterone in males. * Slowly progressive kidney failure can occur in the second to fourth decade of life.
Alström syndrome
McCune–Albright syndrome
Rabson–Mendenhall syndrome
Parry–Romberg syndrome
Wilson–Turner syndrome
Lightwood–Albright syndrome
Leigh syndrome
Wolcott–Rallison syndrome