<unk>  is over-expressed in a number of cancers, and forced over-expression of<unk>  in human cancer cells lines accelerates proliferation and protects cells against apoptosis. HETEs and EETs derived from<unk>  have also been shown to contribute to the proper functioning of the cardiovascular system and the regulation of the renal and pulmonary systems in humans.<unk>  is readily expressed in the cardiac myocytes and endothelial cells of the coronary artery where various EETs are produced. The presence of EETs relaxes vascular smooth muscle cells by hyperpolarizing the cell membrane, thus highlighting the protective anti-inflammatory function of<unk>  in the circulatory system. There is still conflict in studies on the effects of EETs in relation to the cardiovascular system. P450 enzymes have shown both positive and negative effects in the heart, and the production of EETs has been shown to produce vascular protective and vascular depressive mechanisms. The over-expression of<unk>  enhances the activation of mitoKATP, and is believed to confer a physiological benefit by altering the production of reactive oxygen species.
CYP2J2
CYP1A2
CYP2C19
CYP2D6
CYP3A5
CYP2C8
CYP3A4
CYP2C9