After oral or intravenous (IV) administration,<unk>  is rapidly hydrolysed by esterases in blood or the gastrointestinal tract to the active form, isavuconazole. Isavuconazole works by inhibition of lanosterol 14α-demethylase, the enzyme responsible for converting lanosterol to ergosterol by demethylation. The resulting depletion of ergosterol and buildup of lanosterol compromise the structure of the fungal cell membrane. Mammalian cells are resistant to demethylation inhibition by azoles, making the drug effects specific to fungi.
Isavuconazonium
Lisocabtagene maraleucel
Suxamethonium chloride
Amylmetacresol
Cyfluthrin
Meconium
Pivhydrazine
Fomepizole