<unk> , also known as<unk> -site amyloid precursor protein cleaving enzyme 1,<unk> -site APP cleaving enzyme 1 <unk> 1), membrane-associated aspartic protease 2, memapsin-2, aspartyl protease 2, and ASP2, is an enzyme that in humans is encoded by the<unk> 1 gene. Expression of<unk> 1 is observed mainly in neurons.<unk> 1 is an aspartic acid protease important in the formation of myelin sheaths in peripheral nerve cells: in mice the expression of<unk> 1 is high in the postnatal stages, when myelination occurs. The transmembrane protein contains two active site aspartate residues in its extracellular protein domain and may function as a dimer, its cytoplasmic tail is required for the correct maturation and an efficient intracellular trafficking, but doesn't affect the activity. It is produced as a pro-enzyme, the endoproteolitc removal occurs after<unk>  leaves Endoplasmic reticulum, in the Golgi apparatus. In addition the pro-peptide receives additional sugars to increase the molecular mass. and the tail became a palmitoylated. The<unk> 1 expression is influenced by the inflammatory state: during AD the cytokines reduce the PPAR1 an inhibitor of<unk> 1 mRNA).
Beta-secretase 1
Zinc transporter 8
Fibroblast growth factor receptor 3
Prostaglandin-endoperoxide synthase 2
Angiotensin-converting enzyme 2
Signal peptide peptidase
Thiamine transporter 1
Phosphorylase kinase, alpha 1