Opiate<unk>  symptoms and signs can be referred to as the<unk>  triad": decreased level of consciousness, pinpoint pupils and respiratory depression. Other symptoms include seizures and muscle spasms. Sometimes an opiate<unk>  can lead to such a decreased level of consciousness such that the person will not wake up. Because of their effect on the part of the brain that regulates breathing,<unk> s can cause very slow or stopped breathing, during<unk> s, leading to hypoxia or death if left untreated. Hypoxia is typically caused by respiratory depression. The brain uses oxygen to regulate the homeostasis of the body. In animal studies, it was found that<unk> s act on specific regions of the central nervous system associated with respiratory regulation, including the medulla and pons. During cerebral hypoxia, there is a lack of sufficient oxygen supply to the brain. Prolonged lack of oxygenation from respiratory depression can lead to detrimental damage to the brain and spinal cord and can leave the person unable to walk or function normally, even if treatment with naloxone is given. Alcohol also causes respiratory depression and therefore when taken with<unk> s can increase the risk of respiratory depression and death. In young children,<unk>  may not be apparent right away. This is due to absorption, distribution, and metabolism differences between young children and adults, and the higher amount of<unk>  ingestion per kilogram of body weight.
Opioid overdose
Stroke
Nicotine withdrawal
Alcohol intoxication
Benzodiazepine overdose
Hypoglycemia
Carbamate poisoning
Head injury