Symptoms of CARASIL may include spondylosis deformans, lumbago (lower back pain) due to herniated disks, alopecia, spasticity in the limbs leading to gait disturbances, dysarthria, urinary incontinence, pseudobulbular signs, arteriosclerosis of cerebral arteries, mood changes, stroke, and dementia. Individuals with CARASIL may experience spondylosis and alopecia beginning in their teens, although alopecia is not seen in all patients. Other signs of the disease, particularly neurological abnormalities, may present from ages 20-40 with symptoms worsening over time. About 50% of affected patients present with stroke, and most strokes experienced by patients are lacunar<unk> . Many patients experience some form of mood changes, personality disorders, and/or dementia over time.
Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy
Hereditary cystatin C amyloid angiopathy
Walker–Warburg syndrome
Hereditary diffuse leukoencephalopathy with spheroids
Cerebral amyloid angiopathy
Familial British dementia
Moyamoya disease
Subacute sclerosing panencephalitis