One of the unique toxicities of<unk>  is cerebellar toxicity when given in high doses, which may lead to ataxia.<unk>  may cause granulocytopenia and other impaired body defenses, which may lead to infection, and thrombocytopenia, which may lead to hemorrhage. Toxicity: pancreatitis, leukopenia, thrombocytopenia, anemia, GI disturbances, stomatitis, conjunctivitis, pneumonitis, fever, and dermatitis, palmar-plantar erythrodysesthesia. Rarely, myelopathy has been reported after high dose or frequent intrathecal<unk>  administration. When used in protocols designated as high dose,<unk>  can cause cerebral and cerebellar dysfunction, ocular toxicity, pulmonary toxicity, severe GI ulceration and peripheral neuropathy (rare). To prevent the side effects and improve the therapeutic efficiency, various derivatives of these drugs (including amino acid, peptide, fatty acid and phosphates) have been evaluated, as well as different delivery systems.
Cytarabine
Fludarabine
Clofarabine
Cladribine
Nelarabine
Vincristine
Ifosfamide
Cyclophosphamide