After oral administration, maximum plasma concentrations of<unk>  are attained within 3-5 hours and the terminal elimination half-life (t1/2) is about 5 hours in healthy adult subjects. the exposure to<unk>  after intervenous and oral administration is about 2-fold greater in adult patients with pulmonary arterial hypertension than in healthy adult subjects. Absolute bioavailability of<unk>  is about 50% in healthy subjects. Peak plasma concentration of<unk>  with the dispersable tablets for oral suspension is 14% less on average compared to peak concentration of the oral tablets.<unk>  is a substrate of CYP3A4 and CYP2C9. CYP2C19 may also play a role in its metabolism. It is also a substrate of the hepatic uptake transporter organic anion-transporting polypeptides (OATPs) OATP1B1, OATP1B3, and OATP2B1. Elimination of<unk>  is mostly hepatic, with minimal contribution from renal and fecal excretion. Use of<unk>  with cyclosporine is contraindicated because cyclosporine A has been shown to markedly increase serum concentration of<unk> .
Bosentan
Macitentan
Ambrisentan
Sitaxentan
Darusentan
Vericiguat
Nitroxinil
Sildenafil