There are various disease comorbidities associated with<unk> , including: Lymphoproliferative disorders and lymphatic malignancies *Lymphoproliferative disorders, such as monoclonal gammopathy of undetermined significance (MGUS) and non-Hodgkin lymphoma are associated with<unk>  angioedema. In cohort studies, MGUS is considered one of the most common disorders associated with AAE. MGUS is a premalignant plasma cell disorder that is associated with bone marrow pathologic changes leading to abnormal production of M protein that can progress to other hematologic diseases. Additionally, through retrospective case studies performed in France, Gobert et al. found that non-Hodgkin lymphoma was associated with 48% of cases in a sample size of 92 cases of<unk>  angioedema. * Multiple myeloma (MM) is a malignant plasma cell disorder that progresses from MGUS. MM is characterized by elevated monoclonal paraprotein in addition to end organ damage, such as kidney failure. * Lymphoplasmacytic lymphoma (also known as Waldenström macroglobulinemia) is a B cell malignancy with hematologic changes that affect the lymphatic system. Some of the clinical manifestations seen in this lymphoma are anemia, hyperviscosity syndrome, and neuropathy. Autoimmune disorders *Autoimmune disorders, such as systemic lupus erythematosus (SLE) are observed with AAE. SLE is an autoimmune disease with variable manifestations from mild symptoms to multiorgan involvement. The autoantibody component involved in SLE has been investigated and is thought to be associated with angioedema manifestations. *Certain vasculitic diseases, such as eosinophilic granulomatosis with polyangiitis (also known as Churg–Strauss syndrome) have been associated with AAE. Eosinophilic granulomatosis with polyangiitis (EGPA) is an inflammatory disease characterized by necrotizing vasculitis that affects small and medium sized vessels of the body. This vasculitis is associated with certain comorbidities including asthma, rhinosinusitis, and eosinophilia (blood cells responsible for activating immune responses and downstream signals in inflammation). Infections * Human immunodeficiency virus (HIV) is a transmissible retrovirus that can predispose individuals carrying the virus to<unk>  immunodeficiency syndrome (AIDS) which leads to opportunistic infections. * Hepatitis B viral infection (HBV) is a transmissible DNA virus that can potentially lead to liver injury. In a series of cases studies with patients reporting symptoms of angioedema, some of these individuals were found to have positive markers of HBV. Metabolic disorders * Xanthomatosis is a systemic metabolic disorder marked by fatty deposits in the presence of hypercholesterolemia, or high cholesterol. Idiopathic causes * Idiopathic etiology is considered when well-understood and known causes are excluded after a thorough medical evaluation.
Acquired C1 esterase inhibitor deficiency
Hereditary angioedema
Terminal complement pathway deficiency
Type IV hypersensitivity
IgG4-related skin disease
Complement 3 deficiency
Type III hypersensitivity
Complement 2 deficiency