Bleeding<unk>  can increase the risk of bleeding which may be serious and potentially fatal. Concurrent use with other medications that affect blood clotting can further increase this risk. This includes medications such as other anticoagulants, heparin, aspirin, antiplatelet medications, selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, and nonsteroidal anti-inflammatory drugs (NSAIDs). Andexanet alfa is a Food and Drug Administration (FDA) approved antidote for<unk>  in people with uncontrolled and life-threatening bleeding events. Spinal puncture Following spinal anesthesia or puncture, people who are being treated with anti-thrombotic agents are at higher risk for developing a hematoma, which can cause long-term or permanent paralysis. The risk of this may be increased by using epidural or intrathecal catheters after a surgical operation or from the concurrent use of medicinal agents that affect hemostasis.
Apixaban
Enoxaparin sodium
Dabigatran
Rivaroxaban
Palladin
Ticlopidine
Eptifibatide
Ticagrelor