Pharmacodynamics<unk>  has approximately 302% and 234% of the affinity of estradiol for the estrogen receptors (ERs) ERα and ERβ, respectively. The affinity of<unk>  for the ERs is said to be similar to or slightly higher than that of estradiol. Along with diethylstilbestrol,<unk>  has been said to be one of the most potent estrogens known. The total endometrial proliferation dose per cycle of different forms of<unk>  are 70 to 100 mg for oral<unk> , 45 mg for sublingual<unk>  diacetate, and 25 mg for<unk>  dipropionate by intramuscular injection. These doses are fairly similar to those of estradiol and its esters.<unk>  induces mammary gland development in rodents similarly to other estrogens. Pharmacokinetics Distribution of<unk>  radioactivity in blood and tissues after a subcutaneous injection of a physiological dose of tritium-labeled<unk>  in oil solution in five juvenile female goats. Points are one animal each. With the exception of skeletal muscle, tissues with a radioactivity concentration of less than 15% of that of the endometrium are not shown.<unk>  is concentrated in target tissues such as the uterus and vagina due to binding to estrogen receptors. The pharmacokinetics and distribution of<unk>  have been studied with intravenous injection of aqueous solution in women and with subcutaneous injection of oil solution in female goats and sheep.
Hexestrol
Gestodene
Fosfestrol
Moxestrol
Dimestrol
Benzestrol
Dienestrol
Allenestrol