<unk>  has less relative affinity to other steroid hormone receptors than currently available aldosterone antagonists such as eplerenone and spironolactone, which should result in fewer adverse effects like gynaecomastia, impotence, and low libido.<unk>  blocks mineralocorticoid receptors, which makes it a potassium-sparing diuretic. This table compares inhibitory (blocking) concentrations (IC50, unit: nM) of three antimineralocorticoids. Mineralocorticoid receptor inhibition is responsible for the desired action of the drugs, whereas inhibition of the other receptors potentially leads to side effects. Lower values mean stronger inhibition. Spironolactone Eplerenone<unk>  Mineralocorticoid receptor 24 990 18 Glucocorticoid receptor 2400 22,000 >10,000 Androgen receptor 77 21,200 >10,000 Progesterone receptor 740 31,200 >10,000 The above-listed drugs have insignificant affinity for the estrogen receptor.<unk>  acts as an antagonist to mineralocorticoid receptors harboring the S810L mutation, unlike other traditional MR inhibitors such as spironolactone and eplerenone that incidentally act as agonists.
Finerenone
Androstanolone
Lynestrenol
Androstanolone valerate
Allylestrenol
Androstanolone enanthate
Androstanolone propionate
Protollin