<unk>  usually refers to<unk>  occurring in major<unk> s fed by the circulatory system (heart, kidneys, brain, eyes) which can sustain<unk>  due to uncontrolled hypertension, hypotension, or hypovolemia.
End organ damage
Organ dysfunction
Bone marrow suppression
Liver injury
Cytokine storm
Neurotoxicity
Acute liver failure
Toxicity