The syndrome can present with variable symptoms, even between members of the same family harboring the same mutation. Typically most or all tissues are resistant to thyroid hormone, so despite raised measures of serum thyroid hormone the individual may appear euthyroid (have no symptoms of over- or underactivity of the thyroid gland). The most common symptoms are goiter and tachycardia. It has also been linked to some cases of attention deficit hyperactivity disorder (ADHD), although the majority of people with that diagnosis have no thyroid problems. An association with depression has been proposed.
Thyroid hormone resistance
Thyroid dyshormonogenesis
Follicle-stimulating hormone insensitivity
Pituitary ACTH hypersecretion
Inborn errors of steroid metabolism
Isolated growth hormone deficiency
Congenital adrenal hyperplasia
Adrenocorticotropic hormone deficiency