<unk> -induced skin<unk>  is a condition in which skin and subcutaneous tissue<unk>  (tissue death) occurs due to acquired protein C deficiency following treatment with anti-vitamin K anticoagulants (4-hydroxycoumarins, such as<unk> .<unk>  is a rare but severe complication of treatment with<unk>  or related anticoagulants. The typical patient appears to be an obese, middle aged woman (median age 54 years, male to female ratio 1:3). This drug eruption usually occurs between the third and tenth days of therapy with<unk>  derivatives. The first symptoms are pain and redness in the affected area. As they progress, lesions develop a sharp border and become petechial, then hard and purpuric. They may then resolve or progress to form large, irregular, bloody bullae with eventual<unk>  and slow-healing eschar formation. Favored sites are breasts, thighs, buttocks and penis, all areas with subcutaneous fat. In rare cases, the fascia and muscle are involved. Development of the syndrome is associated with the use of large loading doses at the start of treatment.
Warfarin necrosis
Fibrinolysis syndrome
Anemic infarct
Reperfusion injury
Coronary steal
Post-thrombotic syndrome
Gas gangrene
Ischemia