Mechanism of action<unk>  medoxomil lowers blood pressure by blocking the action of angiotensin II at the AT1 receptor, a hormone that contracts blood vessels and reduces water excretion through the kidneys. Pharmacokinetics<unk>  medoxomil is quickly absorbed from the gut, independently of food intake. Maximal blood plasma concentrations are reached after one to three hours. The liver enzyme CYP2C9 is involved in the formation of the two main metabolites, which are pharmacologically inactive; they are the O-deethylation and decarboxylation products of<unk> . Elimination half life is about 11 hours. 55% are excreted via the feces, and 42% via the urine, of which 15% are present as<unk>  and the rest in form of the metabolites.
Azilsartan
Olmesartan
Valsartan
Losartan
Irbesartan
Telmisartan
Cyclothiazide
Chlorothiazide