Nearly half of people with<unk>  do not have symptoms, and are often incidentally discovered to have<unk>  due to abnormal liver function tests. However a substantial proportion have debilitating signs and symptoms of the disease. Signs and symptoms of<unk>  may include severe itching and nonspecific fatigue. Yellowing of the skin and white portion of the eyes may also be seen. Enlargement of the liver and spleen are seen in roughly 40% of affected individuals. Abdominal pain affects about 20% of people with<unk> . Multiple episodes of life-threatening acute cholangitis (infection within the bile ducts) can be seen due to impaired drainage of the bile ducts, which increases the risk of infection. * Dark urine due to excess conjugated bilirubin, which is water-soluble and excreted by the kidneys (i.e. choluria) * Malabsorption, especially of fat, and steatorrhea (fatty stool), due to an inadequate amount of bile reaching the small intestine, leading to decreased levels of the fat-soluble vitamins, A, D, E, and K. * Portal hypertension, a complication of cirrhosis, which can manifest with esophageal and parastomal varices as well as hepatic encephalopathy (mental status alteration/disturbance caused by liver dysfunction and shunting of blood away from the scarred liver; such that ammonia detoxification is reduced with concomitant encephalopathy) or ascites.
Primary sclerosing cholangitis
Autoimmune hepatitis
Secondary sclerosing cholangitis
Fatty liver disease
Primary biliary cholangitis
Alcoholic hepatitis
Ischemic hepatitis
Progressive familial intrahepatic cholestasis