The primary sign of<unk>  is an increase in the creatinine<unk>  well above that which would be considered normal. Commonly, ARC is defined as a creatinine<unk>  of greater than 130 mL/min, but the effects of increased<unk>  on therapy are not directly correlated to a specific number. For this reason, lower cutoffs such as 120 mL/min are used by some, as well as higher cutoffs in young people who typically have higher kidney function to begin with. Another cutoff used is 10% above the upper limit of normal for a certain population. In patients who do not have their creatinine<unk>  or eGFR measured or calculated frequently,<unk>  may be first seen by the failure of certain medications to produce the expected effect in a patient. As an example, an antibiotic that is being administered at recommended doses in accordance with antibiotic sensitivity testing may not be inducing clinical improvement in a person. This may also be recognized if calculated dosages based on pharmacokinetic monitoring are higher than expected for a patient.
Augmented renal clearance
Enhanced permeability and retention effect
Bioconcentration
Electrolyte exclusion effect
Natriuresis
Renal compensation
Prostatic congestion
Adrenal fatigue