<unk>  <unk> , or diffuse parenchymal<unk>  disease (DPLD), is a group of respiratory diseases affecting the interstitium (the tissue and space around the alveoli (air sacs)) of the<unk> s. It concerns alveolar epithelium, pulmonary capillary endothelium, basement membrane, and perivascular and perilymphatic tissues. It may occur when an injury to the<unk> s triggers an abnormal healing response. Ordinarily, the body generates just the right amount of tissue to repair damage, but in<unk> , the repair process is disrupted, and the tissue around the air sacs (alveoli) becomes scarred and thickened. This makes it more difficult for oxygen to pass into the bloodstream. The disease presents itself with the following symptoms: shortness of breath, nonproductive coughing, fatigue, and weight loss, which tend to develop slowly, over several months. The average rate of survival for someone with this disease is between three and five years. The term<unk>  is used to distinguish these diseases from obstructive airways diseases. There are specific types in children, known as children's<unk> s. The acronym ChILD is sometimes used for this group of diseases. Prolonged<unk>  may result in pulmonary fibrosis, but this is not always the case. Idiopathic pulmonary fibrosis is<unk>  for which no obvious cause can be identified (idiopathic) and is associated with typical findings both radiographic (basal and pleural-based fibrosis with honeycombing) and pathologic (temporally and spatially heterogeneous fibrosis, histopathologic honeycombing, and fibroblastic foci). In 2015,<unk> , together with pulmonary sarcoidosis, affected 1.9 million people. They resulted in 122,000 deaths.
Interstitial lung disease
Idiopathic pulmonary fibrosis
Alveolar lung disease
Alcoholic lung disease
Pulmonary interstitial emphysema
Pulmonary alveolar proteinosis
Pulmonary fibrosis
Emphysema