Similar to other benzodiazepines<unk>  has anxiolytic, sedative, hypnotic, amnesic, anticonvulsant and muscle relaxant pharmacological properties.<unk>  binds to the benzodiazepine site of the GABAA receptor where it acts as a full agonist; this action results in an enhanced GABA inhibitory effect at the GABAA receptor which results in the pharmacological effects of<unk> .<unk>  has a short elimination half-life and is less prone to accumulation after repeated dosing compared to longer-acting benzodiazepine agents. It is metabolised via oxidation.<unk>  is metabolised to hydroxy-clotiazepam and desmethyl-clotiazepam. After oral ingestion of a single 5 mg dose of<unk>  by three healthy volunteers the drug was rapidly absorbed. The elimination half-life of the drug and its metabolites range from 6.5 hours to 18 hours.<unk>  is 99 percent bound to plasma protein. In elderly men the elimination half-life is longer and in elderly women the volume of distribution is increased. Individuals with liver impairment have a reduced volume of distribution as well as a reduced total clearance of<unk> ; renal impairment does not affect the kinetics of<unk> . The dose equivalent to 10 mg diazepam is thought to be between 5 and 10 mg<unk> .
Clotiazepam
Diclazepam
Clonazepam
Medazepam
Oxazepam
Phenazepam
Halazepam
Cinolazepam