The<unk>  gene encodes the nuclear hormone receptor for<unk>  D. The most potent natural agonist is calcitriol () and the<unk>  D2 homologue ercalcitriol, ) is also a strong activator. Other forms of<unk>  D bind with lower affinity, as does the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows similarity of sequence to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor include many genes involved in mineral metabolism. The receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer.<unk>  variants that bolster<unk> -D action and that are directly correlated with AIDS progression rates and<unk>  association with progression to AIDS follows an additive model. FokI polymorphism is a risk factor for enveloped virus infection as revealed in a meta-analysis. The importance of this gene has also been noted in the natural aging process were 3’UTR haplotypes of the gene showed an association with longevity.
Vitamin D receptor
Androgen-binding protein
Growth hormone secretagogue receptor
Thyroid peroxidase
Androgen prohormone
Calcitonin gene-related peptide
Retinoblastoma protein
Parathyroid hormone-related protein