In the absence of pharmacological treatment, people with<unk>  tend to deteriorate over time. Recently, survival has increased in severe<unk>  patients with aggressive and proactive supportive respiratory and nutritional support. If left untreated, the majority of children diagnosed with<unk>  type 0 and 1 do not reach the age of 4, recurrent respiratory problems being the primary cause of death. With proper care, milder<unk>  type I cases (which account for approx. 10% of all<unk> 1 cases) live into adulthood. Long-term survival in<unk>  type I is not sufficiently evidenced; however, as of 2007 advances in respiratory support seem to have brought down mortality. In untreated<unk>  type II, the course of the disease is slower to progress and life expectancy is less than the healthy population. Death before the age of 20 is frequent, although many people with<unk>  live to become parents and grandparents.<unk>  type III has normal or near-normal life expectancy if standards of care are followed. Type IV, adult-onset<unk>  usually means only mobility impairment and does not affect life expectancy.
Spinal muscular atrophy
Prader–Willi syndrome
Spinal and bulbar muscular atrophy
Duchenne muscular dystrophy
Madras motor neuron disease
Congenital muscular dystrophy
Muscular dystrophy
Distal spinal muscular atrophy type 1