<unk>  (HCA2), also known as niacin receptor 1 (NIACR1) and GPR109A, is a protein which in humans is encoded by the HCAR2 gene. HCA2, like the other<unk> <unk>  receptors HCA1 and HCA3, is a Gi/o-coupled G protein-coupled receptor (GPCR). The primary endogenous agonists of HCA2 are -β-hydroxybutyric<unk>  and butyric<unk>  (and their conjugate bases, β-hydroxybutyrate and butyrate). HCA2 is also a high-affinity biomolecular target for niacin (aka nicotinic<unk> . HCA2 activation inhibits lipolytic and atherogenic activity (i.e., it inhibits the breakdown of fats and the development of atherosclerosis), induces vasodilation (i.e., the dilation of blood vessels), and is responsible for mediating niacin-induced flushing.
Hydroxycarboxylic acid receptor 2
Growth hormone secretagogue receptor
Norepinephrine transporter
Prolactin-releasing peptide receptor
G protein-coupled receptor kinase 3
Thiamine transporter 1
Tropomyosin receptor kinase A
Prostaglandin-endoperoxide synthase 2