<unk>  (or SHM) is a cellular mechanism by which the immune system adapts to the new foreign elements that confront it (e.g. microbes), as seen during class switching. A major component of the process of affinity maturation, SHM diversifies B cell receptors used to recognize foreign elements (antigens) and allows the immune system to adapt its response to new threats during the lifetime of an organism.<unk>  involves a programmed process of mutation affecting the variable regions of immunoglobulin genes. Unlike germline mutation, SHM affects only an organism's individual immune cells, and the mutations are not transmitted to the organism's offspring. Mistargeted<unk>  is a likely mechanism in the development of B-cell lymphomas and many other cancers.
Somatic hypermutation
Hair cloning
Osseoincorporation
Prime editing
Gene duplication
Exon shuffling
Autoamputation
Genome editing