The two enantiomers of the<unk>  molecule, levofloxacin or S-ofloxacin (top) and dextrofloxacin or R-ofloxacin (bottom). Only levofloxacin is biologically active, and is thus solely responsible for the effects of the drug. The bioavailability of<unk>  in the tablet form is roughly 98% following oral administration, reaching maximum serum concentrations within one to two hours. Between 65% and 80% of an administered oral dose of<unk>  is excreted unchanged via the kidneys within 48 hours of dosing. Therefore, elimination is mainly by renal excretion. However, 4-8% of an<unk>  dose is excreted in the feces. This would indicate a small degree of biliary excretion, as well. Plasma elimination half-life is around 4 to 5 hours in patients and 6.4 to 7.4 hours in elderly patients.<unk>  is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin. "After multiple-dose administration of 200 mg and 300 mg doses, peak serum levels of 2.2 and 3.6 μg/ml, respectively, are predicted at steady-state. In vitro, approximately 32% of the drug in plasma is protein bound. Floxin is widely distributed to body tissues.<unk>  has been detected in blister fluid, cervix, lung tissue, ovary, prostatic fluid, prostatic tissue, skin, and sputum. Pyridobenzoxazine ring appears to decrease the extent of parent compound metabolism. Less than 5% is eliminated by the kidneys as desmethyl or N-oxide metabolites; 4% to 8% by feces." A number of the endogenous compounds have been reported to be affected by<unk>  as inhibitors, alteraters, and depletors. See the latest package insert for<unk>  for additional details.
Ofloxacin
Norfloxacin
Sparfloxacin
Enrofloxacin
Ciprofloxacin
Delafloxacin
Alatrofloxacin
Merafloxacin