Mechanism of action<unk>  is a synthetic pentasaccharide factor Xa inhibitor.<unk>  binds antithrombin and accelerates its inhibition of factor Xa. Apart from the O-methyl group at the reducing end of the molecule, the identity and sequence of the five monomeric sugar units contained in<unk>  is identical to a sequence of five monomeric sugar units that can be isolated after either chemical or enzymatic cleavage of the polymeric glycosaminoglycans heparin and heparan sulfate (HS). Within heparin and heparan sulfate this monomeric sequence is thought to form the high-affinity binding site for the anti-coagulant factor antithrombin (AT). Binding of heparin or HS to AT has been shown to increase the anti-coagulant activity of antithrombin 1000 fold. In contrast to heparin,<unk>  does not inhibit thrombin.
Fondaparinux
Palladin
Apixaban
Tinzaparin sodium
Enoxaparin sodium
Argatroban
Avatrombopag
Bivalirudin