<unk> <unk> , also called<unk><unk><unk>  polyneuropathy <unk> , is a<unk>  caused by killing of neurons in the central nervous system, especially in the spinal cord, as a result of acute or chronic<unk>  poisoning. A striking example of<unk>  occurred during the 1930s Prohibition Era when thousands of men in the American South and Midwest developed arm and leg weakness and pain after drinking a "medicinal" alcohol substitute. The drink, called "Ginger Jake," contained an adulterated Jamaican ginger extract containing tri-ortho-cresyl phosphate (TOCP) which resulted in partially reversible neurologic damage. The damage resulted in the limping called "jake paralysis" – and also "jake leg" or "jake walk", which were terms frequently used in the blues music of the period. Europe and Morocco both experienced outbreaks of TOCP poisoning from contaminated abortifacients and cooking oil, respectively. The disorder may contribute to the chronic multisymptom illnesses of the Gulf War veterans as well as aerotoxic syndrome (especially tricresyl phosphate poisoning) The exact cause of the syndrome is unknown, although it has been associated with inhibition of patatin-like phospholipase domain-containing protein 6 (PNPLA6, aka<unk>  target esterase). There is no specific treatment, and recovery is usually incomplete, affecting only sensory nervous system, while motor<unk>  persists.
Organophosphate-induced delayed neuropathy
Calcium channel blocker toxicity
Thyrotoxic myopathy
Acute beryllium poisoning
Secondary poisoning
Organophosphate poisoning
Anticonvulsant hypersensitivity syndrome
Neurotoxic shellfish poisoning