Suggestive features Routine laboratory investigations may show: * Low blood sugar (worse in children due to loss of glucocorticoid's glucogenic effects) * Low blood sodium, due to loss of production of the hormone aldosterone, to the kidney's inability to excrete free water in the absence of sufficient cortisol, and also the effect of corticotropin-releasing hormone to stimulate secretion of<unk> H. * High blood potassium, due to loss of production of the hormone aldosterone. * Eosinophilia and lymphocytosis (increased number of eosinophils or lymphocytes, two types of white blood cells) * Metabolic acidosis (increased blood acidity), also is due to loss of the hormone aldosterone because sodium reabsorption in the distal tubule is linked with acid/hydrogen ion (H+) secretion. Absent or insufficient levels of aldosterone stimulation of the renal distal tubule lead to sodium wasting in the urine and H+ retention in the serum. Testing Cortisol Aldosterone In suspected cases of<unk> , demonstration of low<unk> renal hormone levels even after appropriate stimulation (called the ACTH stimulation test or synacthen test) with synthetic pituitary ACTH hormone tetracosactide is needed for the diagnosis. Two tests are performed, the short and the long test. Dexamethasone does not cross-react with the assay and can be<unk> ministered concomitantly during testing. The short test compares blood cortisol levels before and after 250 micrograms of tetracosactide (intramuscular or intravenous) is given. If one hour later, plasma cortisol exceeds 170 nmol/l and has risen by at least 330 nmol/l to at least 690 nmol/l,<unk> renal failure is excluded. If the short test is abnormal, the long test is used to differentiate between primary<unk> renal insufficiency and secondary<unk> renocortical insufficiency. The long test uses 1 mg tetracosactide (intramuscular). Blood is taken 1, 4, 8, and 24 hr later. Normal plasma cortisol level should reach 1000 nmol/l by 4 hr. In primary<unk> , the cortisol level is reduced at all stages, whereas in secondary corticoadrenal insufficiency, a delayed but normal response is seen.Other tests may be performed to distinguish between various causes of hypoadrenalism, including renin and<unk> renocorticotropic hormone levels, as well as medical imaging – usually in the form of ultrasound, computed tomography or magnetic resonance imaging.<unk> renoleukodystrophy, and the milder form,<unk> renomyeloneuropathy, cause<unk> renal insufficiency combined with neurological symptoms. These<unk> s are estimated to be the cause of<unk> renal insufficiency in about 35% of diagnosed males with idiopathic<unk>  and should be considered in the differential diagnosis of any male with<unk> renal insufficiency. Diagnosis is made by a blood test to detect very long-chain fatty acids.
Addison's disease
Sheehan's syndrome
Cushing's disease
Wilson's temperature syndrome
Sneddon's syndrome
complications of Acromegaly
Zieve's syndrome
Young's syndrome