<unk>  affects an estimated 2.5–15% of the American population. A minority (around 2.7% of the population) experience daily or severe symptoms.<unk>  is twice as common in women as in men, and Caucasians are more prone to<unk>  than people of African descent.<unk>  occurs in 3% of individuals from the Mediterranean or Middle Eastern regions, and in 1–5% of those from East Asia, indicating that different genetic or environmental factors, including diet, may play a role in the prevalence of this<unk> .<unk>  diagnosed at an older age runs a more severe course.<unk>  is even more common in individuals with iron deficiency, pregnancy, or end-stage kidney disease. The National Sleep Foundation's 1998 Sleep in America poll showed that up to 25 percent of pregnant women developed<unk>  during the third trimester. Poor general health is also linked. There are several risk factors for<unk> , including old age, family history, and uremia. The prevalence of<unk>  tends to increase with age, as well as its severity and longer duration of symptoms. People with uremia receiving renal dialysis have a prevalence from 20% to 57%, while those having kidney transplant improve compared to those treated with dialysis.<unk>  can occur at all ages, although it typically begins in the third or fourth decade. Genome‐wide association studies have now identified 19 risk loci associated with<unk> . Neurological conditions linked to<unk>  include Parkinson's disease, spinal cerebellar atrophy, spinal stenosis, lumbosacral radiculopathy and Charcot–Marie–Tooth disease type 2.
Restless legs syndrome
Akathisia
Parkinsonism
Insomnia
Cancer-related fatigue
Gigantism
Bruxism
Lonomia