Surgical removal and/or radiotherapy is given for localized disease. Radiation using multiple radiation fields is given if the disease has wider extent with grouped lesions. For the less common situation of more extensive disease (still confined to skin), rituximab without chemotherapy is used. Intralesional interferon alpha (IFN-α) and intralesional rituximab have been used. Approximately one-third of PCFCL relapse, usually in the skin; treatment is similar to initial management and overall survival remains excellent.
Primary cutaneous follicle center lymphoma
Primary cutaneous immunocytoma
Cutaneous T cell lymphoma
Primary cutaneous marginal zone lymphoma
Cutaneous B-cell lymphoma
Generalized eruptive histiocytoma
Subcutaneous T-cell lymphoma
Cutaneous lymphoma