<unk>  belongs to the thiazide class of diuretics. It reduces blood volume by acting on the kidneys to reduce sodium (Na+) reabsorption in the distal convoluted tubule. The major site of action in the nephron appears on an electroneutral NaCl co-transporter by competing for the chloride site on the transporter. By impairing Na+ transport in the distal convoluted tubule,<unk>  induces a natriuresis and concomitant water loss. Thiazides increase the reabsorption of calcium in this segment in a manner unrelated to sodium transport. Additionally, by other mechanisms,<unk> CTZ is believed to lower peripheral vascular resistance.
Hydrochlorothiazide
Chlorothiazide
Cyclothiazide
Spironolactone
Amiloride
Furosemide
Azaperone
Torasemide