<unk> can intensify the sedation caused by other central nervous system depressants such as barbiturates, benzodiazepines, opioids, nonbenzodiazepines/Z-drugs (such as zolpidem and zopiclone), antipsychotics, sedative antihistamines, and certain antidepressants. It interacts with cocaine in vivo to produce cocaethylene, another psychoactive substance. Ethanol enhances the bioavailability of methylphenidate (elevated plasma dexmethylphenidate). In combination with cannabis, ethanol increases plasma tetrahydrocannabinol levels, which suggests that ethanol may increase the absorption of tetrahydrocannabinol. Disulfiram-like drugs Disulfiram Disulfiram inhibits the enzyme acetaldehyde dehydrogenase, which in turn results in buildup of acetaldehyde, a toxic metabolite of ethanol with unpleasant effects. The medication or drug is commonly used to treat<unk> use disorder, and results in immediate hangover-like symptoms upon consumption of<unk>  this effect is widely known as disulfiram effect. Metronidazole One of the most important drug/food interactions is between<unk> and metronidazole. Metronidazole is an antibacterial agent that kills bacteria by damaging cellular DNA and hence cellular function. Metronidazole is usually given to people who have diarrhea caused by Clostridium difficile bacteria. C. difficile is one of the most common microorganisms that cause diarrhea and can lead to complications such as colon inflammation and even more severely, death. Patients who are taking metronidazole are sometimes advised to avoid<unk>  even after 1 hour following the last dose. Although older data suggested a possible disulfiram-like effect of metronidazole, newer data has challenged this and suggests it does not actually have this effect. Methanol and ethylene glycol The rate-limiting steps for the elimination of ethanol are in common with certain other substances. As a result, the blood<unk> concentration can be used to modify the rate of metabolism of methanol and ethylene glycol. Methanol itself is not highly toxic, but its metabolites formaldehyde and formic acid are; therefore, to reduce the rate of production and concentration of these harmful metabolites, ethanol can be ingested. Ethylene glycol poisoning can be treated in the same way.
Alcohol 
Toxic alcohol
Benzyl alcohol
Tobacco
Cannabis
Cannabis 
Smokeless tobacco
Polychlorinated biphenyl