<unk>  is metabolized by the liver enzyme CYP2D6, so CYP2D6 inhibitors will prolong the elimination half-life of<unk> .<unk>  also interacts with monoamine oxidase inhibitors (MAOIs), since both MAOIs and<unk>  increase plasma catecholamines; therefore, concurrent use of both is dangerous.<unk>  may decrease the effects of sedatives and depressants and increase the effects of antidepressants and other stimulants as well.<unk>  may counteract the effects of antihypertensives and antipsychotics due to its effects on the cardiovascular system and cognition respectively. The pH of gastrointestinal content and urine affects the absorption and excretion of<unk> . Specifically, acidic substances will reduce the absorption of<unk>  and increase urinary excretion, while alkaline substances do the opposite. Due to the effect pH has on absorption, proton pump inhibitors, which reduce gastric acid, are known to interact with<unk> .
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Cannabis
Cannabis 
Nicotine