Prognosis is favourable in comparison with classic HL despite a tendency for disease recurrence requiring long term followup. Relapse can occur at a comparatively late stage in comparison to classic HL. There is limited information regarding the outcome for patients with advanced-stage progression. Ethnicity One study in the United States has suggested improved overall survival in response to chemotherapy for African Americans. Histological Transformation Histologic transformation to diffuse large B-cell<unk>  (DLBCL) can occur in up to 12% of cases. After transformation, neoplastic cells carry monoclonal immunoglobulin gene rearrangements. Histological transformation may lead to poor prognosis and therefore repeat biopsy is required at relapse. One study found a transformation rate of 7.6%, and suggested that prior exposure to chemotherapy and a presentation with splenic involvement were associated with increased risks of transformation.
Nodular lymphocyte predominant Hodgkin lymphoma
Indolent lymphoma
Pediatric-type follicular lymphoma
Epstein–Barr virus positive diffuse large B-cell lymphoma, not otherwise specified
Duodenal-type follicular lymphoma
Gray zone lymphoma
Aggressive lymphoma
Extranodal NK/T-cell lymphoma, nasal type