<unk>  is the major metabolite of the opioid analgesic hydrocodone. It is formed from hydrocodone in the liver via N-demethylation predominantly by CYP3A4. Unlike hydromorphone, a minor metabolite of hydrocodone,<unk>  is described as inactive. However,<unk>  is actually an agonist of the μ-opioid receptor with similar potency to hydrocodone, but has been found to produce only minimal analgesia when administered peripherally to animals. This is likely due to poor blood-brain-barrier and thus central nervous system penetration.
Norhydrocodone
Noroxycodone
Hydrocodone
Oxycodone
Nefazodone
Vilazodone
Hydroxynefazodone
Pafolacianine