Histpathologically, hemotoxin and eosin dye-stained and otherwise properly prepared LPF-NT tissues consist of mildly to moderately atypical spindle-shaped cells that variably infiltrate into subcutaneous adipose (i.e. fat) tissues. The spindle-shaped cells commonly have indistinct nucleoli borders (nucleoli are the largest structures in a cell's nucleus), hyperchromasia (i.e. nuclei that are denser than normal), pale to slightly eosinophilic (i.e. taking up more eosin dye than normal) cytoplasm, and a low rate of cell division as determined by mitotic index analysis. Cases showing tissue necrosis (i.e. foci of dead or dying cells) are rare. The spindle-shaped cells espress S100 and CD34 marker proteins in a variable proportion of cases. One study found that the cells in five of five LDF-NTs overexpress, i.e. contain increased numbers of, one or more of the three Trk receptors (i.e. TrkA, TrkB, and TrkC) as judged using a pan-TRK immunohistochemistry assay. This assay uses a Pan-Trk antibody, i.e. an antibody that binds with and thereby enables the enumeration of all three Trk proteins. Other studies have found that this finding in LPF-NTs is due to overexpression of the TrkA receptor.<unk>  tissues that have a histopathology compatible with LPF-NT plus spindle-shaped cells that express D34 and S100 but not SOX10 marker proteins are almost certainly LPF-NTs.
Lipofibromatosis-like neural tumor
Neural fibrolipoma
Eccrine angiomatous hamartoma
Embryonal tumour with multilayered rosettes
Folliculosebaceous cystic hamartoma
Intranodal palisaded myofibroblastoma
Perivascular epithelioid cell tumour
Aggressive angiomyxoma