Various<unk>  pills The most common adverse effects of short-term use include headache (reported by 7% of people in clinical trials), drowsiness (2%), dizziness (1%), and diarrhea (1%); the most common side effects of long-term use included drowsiness (8%), dizziness (5%), allergy (4%), sinusitis (4%), back pain (3%), diarrhea (3%), drugged feeling (3%), dry mouth (3%), lethargy (3%), sore throat (3%), abdominal pain (2%), constipation (2%), heart palpitations (2%), lightheadedness (2%), rash (2%), abnormal dreams (1%), amnesia (1%), chest pain (1%), depression (1%), flu-like symptoms (1%), and sleep disorder (1%).<unk>  increases risk of depression, falls and bone fracture, poor driving, suppressed respiration, and has been associated with an increased risk of death. Upper and lower respiratory infections are also common (experienced by between 1 and 10% of people). Residual 'hangover' effects, such as sleepiness and impaired psychomotor and cognitive function, may persist into the day following nighttime administration. Such effects may impair the ability of users to drive safely and increase risks of falls and hip fractures. Around 3% of people taking<unk>  are likely to break a bone as a result of a fall due to impaired coordination caused by the drug. Some users have reported unexplained sleepwalking while using<unk> , as well as sleep driving, night eating syndrome while asleep, and performing other daily tasks while sleeping. Research by Australia's National Prescribing Service found these events occur mostly after the first dose taken, or within a few days of starting therapy. In February 2008, the Australian Therapeutic Goods Administration attached a boxed warning concerning this adverse effect. Tolerance, dependence and withdrawal Ambien tablets As<unk>  is associated with drug tolerance and substance dependence, its prescription guidelines are only for severe insomnia and short periods of use at the lowest effective dose. Tolerance to the effects of<unk>  can develop in some people in just a few weeks. Abrupt withdrawal may cause delirium, seizures, or other adverse effects, especially if used for prolonged periods and at high doses. When drug tolerance and physical dependence to<unk>  develop, treatment usually entails a gradual dose reduction over a period of months to minimize withdrawal symptoms, which can resemble those seen during benzodiazepine withdrawal. Failing that, an alternative method may be necessary for some people, such as a switch to a benzodiazepine equivalent dose of a longer-acting benzodiazepine drug, as for diazepam or chlordiazepoxide, followed by a gradual reduction in dose of the long-acting benzodiazepine. In people who are difficult to treat, an inpatient flumazenil administration allows for rapid competitive binding of flumazenil to GABAA–receptor as an antagonist, thus stopping (and effectively detoxifying)<unk>  from being able to bind as an agonist on GABAA–receptor; slowly drug dependence or addiction to<unk>  will wane. Alcohol has cross tolerance with GABAA receptor positive allosteric modulators, such as the benzodiazepines and the nonbenzodiazepine drugs. For this reason, alcoholics or recovering alcoholics may be at increased risk of physical dependency or abuse of<unk> . It is not typically prescribed in people with a history of alcoholism, recreational drug use, physical dependency, or psychological dependency on sedative-hypnotic drugs. A 2014 review found evidence of drug-seeking behavior, with prescriptions for<unk>  making up 20% of falsified or forged prescriptions. Rodent studies of the tolerance-inducing properties have shown that<unk>  has less tolerance-producing potential than benzodiazepines, but in primates, the tolerance-producing potential of<unk>  was the same as seen with benzodiazepines. Overdose Overdose can lead to coma or death. When overdose occurs, there are often other drugs in the person's system.<unk>  overdose can be treated with the GABAA receptor antagonist flumazenil, which displaces<unk>  from its binding site on the GABAA receptor to rapidly reverse the effects of the<unk> . It is unknown if dialysis is helpful. Detection in body fluids<unk>  may be quantitated in blood or plasma to confirm a diagnosis of poisoning in people who are hospitalized, to provide evidence in an impaired driving arrest, or to assist in a medicolegal death investigation. Blood or plasma<unk>  concentrations are usually in a range of 30–300μg/l in persons receiving the drug therapeutically, 100–700μg/l in those arrested for impaired driving, and 1000–7000μg/l in victims of acute overdosage. Analytical techniques, in general, involve gas or liquid chromatography.
Zolpidem
Medazepam
Halazepam
Cinolazepam
Oxazepam
Nimetazepam
Dimethazan
Premazepam