<unk> . <unk>  () is an enzyme that catalyzes the hydroxylation of the aromatic side-chain of<unk> enylalanine to generate tyrosine.<unk>  is one of three members of the biopterin-dependent aromatic amino acid<unk> s, a class of monooxygenase that uses tetrahydrobiopterin (BH4, a pteridine cofactor) and a non-heme iron for catalysis. During the reaction, molecular oxygen is heterolytically cleaved with sequential incorporation of one oxygen atom into BH4 and<unk> enylalanine substrate. In humans, mutations in its encoding gene,<unk> , can lead to the metabolic disorder<unk> enylketonuria. Reaction catalyzed by<unk>
Phenylalanine hydroxylase
Aromatic L-amino acid decarboxylase
Catechol-O-methyltransferase
Tyrosine hydroxylase
Dopamine beta-hydroxylase
Glutamate dehydrogenase
Monoamine oxidase B
Monoamine oxidase