In October 2020, the U.S. Food and Drug Administration (FDA) required the drug label to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in unborn babies that result in low amniotic fluid. They recommend avoiding NSAIDs in pregnant women at 20 weeks or later in pregnancy. Gastrointestinal The inhibition of prostaglandins has the effect of decreasing the protection given to the stomach from its own acid. Like all NSAIDS, this leads to an increased risk of stomach ulcers, and their complications, with long-term use. Elderly users of<unk>  are at greater risk for serious GI events. *Increased risk of GI events including bleeding, ulceration, and stomach or intestine perforation. *Abdominal pain or cramps *Constipation *Gas *Diarrhea *Nausea and vomiting *Dyspepsia Cardiovascular *Irregular heart beat *Possible increased risk of serious and potentially fatal cardiovascular thrombotic events, MI, and stroke *Risks may increase with duration of use and for cardiovascular disease history Ear, nose, throat, and eye *Ringing in the ears *Yellowing of eyes Central nervous system *Drowsiness *Dizziness *Headache *Insomnia *Fatigue *Somnolence *Nervousness Skin *Swelling of the feet, ankles, lower legs, and hands *Yellowing of skin *Rash *Ecchymosis
Diflunisal
Chloropicrin
Tralomethrin
Diflorasone diacetate
Flumetasone
Budesonide
Zopiclone
Terfenadine