Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the<unk>  () gene. Orthologs are common in other vertebrate species, whereas invertebrate genomes may encode a more distantly related gene.<unk>  is a human tumor suppressor gene (also known as a caretaker gene) and is responsible for repairing DNA.<unk>  and<unk>  are unrelated proteins, but both are normally expressed in the cells of breast and other tissue, where they help repair damaged DNA, or destroy cells if DNA cannot be repaired. They are involved in the repair of chromosomal damage with an important role in the error-free repair of DNA double-strand breaks. If<unk>  or<unk>  itself is damaged by a<unk> mutation, damaged DNA is not repaired properly, and this increases the risk for breast cancer.<unk>  and<unk>  have been described as "breast cancer susceptibility genes" and "breast cancer susceptibility proteins". The predominant allele has a normal, tumor suppressive function whereas high penetrance mutations in these genes cause a loss of tumor suppressive function which correlates with an increased risk of breast cancer.<unk>  combines with other tumor suppressors, DNA damage sensors and signal transducers to form a large multi-subunit protein complex known as the<unk> -associated genome surveillance complex (BASC). The<unk>  protein associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. Thus, this protein plays a role in transcription, and DNA repair of double-strand DNA breaks ubiquitination, transcriptional regulation as well as other functions. Methods to test for the likelihood of a patient with mutations in<unk>  and<unk>  developing cancer were covered by patents owned or controlled by Myriad Genetics. Myriad's business model of offering the diagnostic test exclusively led from Myriad being a startup in 1994 to being a publicly traded company with 1200 employees and about $500M in annual revenue in 2012; it also led to controversy over high prices and the inability to obtain second opinions from other diagnostic labs, which in turn led to the landmark Association for Molecular Pathology v. Myriad Genetics lawsuit.
BRCA1
FCER1
ERCC2
INK4
WRAP53
KRAS
CoWIN
BRAF 