<unk>  (MNS), also known as<unk><unk>  osteodysplasty, is an extremely rare congenital disorder that affects primarily bone development. Patients with<unk>  have typical faces (exophthalmos, full cheeks, micrognathia and malalignment of teeth), flaring of the metaphyses of long bones, s-like curvature of bones of legs, irregular constrictions in the ribs, and sclerosis of base of skull. In males, the disorder is nearly always lethal in infancy. Lifespan of female patients might not be affected.<unk>  is associated with mutations in the FLNA gene and is inherited in an X-linked dominant manner. As with many genetic disorders, there is no known cure to MNS. The disorder was first described by John C.<unk>  and Carl F.<unk>  in 1966 in two multi-generational families.
Melnick–Needles syndrome
Multiple epiphyseal dysplasia
Bogart–Bacall syndrome
Young–Simpson syndrome
Michels Caskey syndrome
Senior–Løken syndrome
Rapunzel syndrome
Fryns-Aftimos syndrome