The molecular mechanisms underlying JS are unknown. Broadly, PP2A dysfunction is known to be associated with other pathologies such as Alzheimer's disease, Parkinson's disease, and cancer. Studies of specific JS-causing variants such as E420K have implicated PI3K/AKT/mTOR pathway dysregulation in JS pathogenesis.
Jordan's Syndrome
Cervicitis
Acute prostatitis
Appendicitis
Hidradenitis
Otitis externa
Urethral syndrome
Sacroiliitis