Most often a type of dystrophic<unk> , the initial stage of<unk>  may begin with microscopic tissue damage to the endothelial cells of the annulus fibrosis, prompting changes that result in the atherosclerosis-like deposition of lipids and ultimately<unk>  of these areas. This explains why<unk>  is commonly seen in individuals of advanced age or those having an underlying genetic or inflammatory condition that predisposes to tissue damage (see associated causes below). It is also associated with conditions that cause Left Ventricular Hypertrophy, likely because the resulting mechanical stress on the cardiac tissues also predisposes to annulus damage from increasingly turbulent blood flow.
Mitral annular calcification
Bicuspid aortic valve
Quadricuspid aortic valve
Supravalvular aortic stenosis
Flutter valve
Mitral annular disjunction
Accessory auricle
Overriding aorta