Children are born with this condition and their symptoms can be seen immediately. In the early stages these can appear quite mild; weak muscle tone (often extreme hypotonia), lack of neonatal reflexes, seizures and abnormal (dysmorphic) facial features such as widely spaced eyes, a low nasal bridge, low set ears and an abnormally large forehead. Due to the nature of the disease, in the build-up of VLCFAs, symptoms worsen progressively over time. Children can often reach the stage at which they begin to walk and talk, before experiencing a rapid decline in motor skills due to demyelination and subsequent nerve damage. A hearing deficit may develop, eyesight and response to visual and physical stimuli begins to diminish and eventually becomes non-existent. The life expectancy of an individual with ACOX1<unk>  is 5 years.
Acyl-CoA oxidase deficiency
2,4 Dienoyl-CoA reductase deficiency
3-Methylcrotonyl-CoA carboxylase deficiency
2-Methylbutyryl-CoA dehydrogenase deficiency
Multiple carboxylase deficiency
Carnitine-acylcarnitine translocase deficiency
Pyruvate kinase deficiency
Malonyl-CoA decarboxylase deficiency