<unk>  is characterised by<unk>  cells.<unk>  cells are large cells with clear cytoplasm (clear halo) and eccentric, hyperchromic nuclei found throughout the epidermis. There is some controversy as to whether these cells arise from the ductal system of the breast, or whether these cells are a result of in situ malignant transformation. According to the migratory theory, ductal carcinoma in situ cells migrate into the lactiferous sinuses and the nipple skin. Cancer cells disrupt the normal epithelial barrier and extracellular fluid accumulates on the surface of the skin, resulting in the crusting of the areola skin.
Paget's disease of the breast
Hereditary lobular breast cancer
Breast eczema
Adenomyoepithelioma of the breast
Medullary breast carcinoma
Mucinous carcinoma of the breast
Duct ectasia of breast
Papillomatosis of breasts