The several different causes of lactic acidosis include: * Genetic conditions * Biotinidase deficiency, multiple<unk>  deficiency, or nongenetic deficiencies of biotin * Diabetes mellitus and deafness * Fructose 1,6-bisphosphatase deficiency * Glucose-6-phosphatase deficiency * GRACILE syndrome * Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes * Pyruvate dehydrogenase deficiency * Pyruvate<unk>  deficiency * Leigh syndrome * Drugs *Linezolid * Paracetamol/acetaminophen poisoning *Metformin: this risk is low (less than 10 cases for 100,000 patient years), but the risk of metformin-induced lactic acidosis (MALA) increases in certain situations where both the plasma levels of metformin are increased and lactate clearance is impaired. The older related and now withdrawn drug phenformin carried a much higher risk of lactic acidosis. *Isoniazid toxicity *Propofol *Epinephrine *Propylene glycol (D-lactic acidosis) *Nucleoside reverse-transcriptase inhibitors *Abacavir/dolutegravir/lamivudine *Emtricitabine/tenofovir *Potassium cyanide (cyanide poisoning) *Fialuridine * Other * Thiamine deficiency (especially during TPN) * Impaired delivery of oxygen to cells in the tissues (e.g., from impaired blood flow (hypoperfusion)) * Bleeding * Polymyositis * Ethanol toxicity * Sepsis * Shock * Advanced liver disease * Diabetic ketoacidosis * Excessive exercise (overtraining) * Regional hypoperfusion (e.g., bowel ischemia or marked cellulitis) * Cancers such as Non-Hodgkin's and Burkitt lymphomas * Pheochromocytoma * Tumor lysis syndrome * D-lactic acidosis due to intestinal bacterial flora production in short gut syndrome
symptom of Pyruvate carboxylase deficiency
symptom of Glucose-6-phosphate dehydrogenase deficiency
symptom of Adenylosuccinate lyase deficiency
symptom of Phenylketonuria
symptom of Glycogen storage disease type III
symptom of Dubin–Johnson syndrome
symptom of Beta-mannosidosis
complications of Pyruvate carboxylase deficiency