Substances that strongly inhibit the liver enzyme CYP3A4, such as ketoconazole, itraconazole or clarithromycin, increase<unk>  concentrations in the body. In a study, ketoconazole increased its AUC by 75%. Conversely, substances that strongly induce CYP3A4 lower<unk>  concentrations. For example, rifampicin reduced the AUC by 60% in a study.<unk>  seems to be a weak inducer of CYP3A4, as it lowers concentrations of other substrates of this enzyme (such as the midazolam AUC by 26%). It has no effect on substrates of CYP1A2, CYP2B6, CYP2C9, CYP2C19 or CYP2D6.
Upadacitinib
Abrocitinib
Selpercatinib
Baricitinib
Erdafitinib
Oclacitinib
Dacomitinib
Axitinib