An early warning sign (prodrome) of the possibility of developing<unk> , especially in a chronic<unk> , would be weight loss because this usually signifies a nutritional deficiency that can lead to the development of the disease.<unk>  usually has a gradual onset over months or even years, although axonal degeneration often begins before an individual experiences any symptoms. The disease typically involves sensory issues and motor loss, as well as painful physical perceptions, though all sensory modalities may be involved. Symptoms that affect the sensory and motor systems seem to develop symmetrically. For example, if the right foot is affected, the left foot is affected simultaneously or soon becomes affected. In most cases, the legs are affected first, followed by the arms. The hands usually become involved when the symptoms reach above the ankle. This is called a stocking-and-glove pattern of sensory disturbances. Sensory Common manifestations of sensory issues include numbness or painful sensations in the arms and legs, abnormal sensations like “pins and needles,” and heat intolerance. Pain experienced by individuals depends on the severity of the polyneuropathy. It may be dull and constant in some individuals while being sharp and lancinating in others. In many subjects, tenderness is seen upon the palpitation of muscles in the feet and legs. Certain people may also feel cramping sensations in the muscles affected and others say there is a burning sensation in their feet and calves. Motor Sensory symptoms are gradually followed by motor symptoms. Motor symptoms may include muscle cramps and weakness, erectile dysfunction in men, problems urinating, constipation, and diarrhea. Individuals also may experience muscle wasting and decreased or absent deep tendon reflexes. Some people may experience frequent falls and gait unsteadiness due to ataxia. This ataxia may be caused by cerebellar degeneration, sensory ataxia, or distal muscle weakness. Over time,<unk>  may also cause difficulty swallowing (dysphagia), speech impairment (disarthria), muscle spasms, and muscle atrophy. In addition to<unk> , the individual may also show other related disorders such as Wernicke–Korsakoff syndrome and cerebellar degeneration that result from<unk> m-related nutritional disorders. Severity Polyneuropathy spans a large range of severity. Some cases are seemingly asymptomatic and may only be recognized on careful examination. The most severe cases may cause profound physical disability.
Alcoholic polyneuropathy
Tropical neuropathy
Diabetic neuropathy
Critical illness polyneuropathy
Chronic inflammatory demyelinating polyneuropathy
Paraneoplastic cerebellar degeneration
Vasculitic neuropathy
Polyneuropathy