Like oxcarbazepine,<unk>  can reduce plasma levels of drugs that are metabolized by the liver enzymes CYP3A4 (verified in studies for simvastatin and the oral contraceptive levonorgestrel/ethinylestradiol) and UDP-glucuronosyltransferase, and increase plasma levels of drugs metabolized by CYP2C19. Interaction studies have been conducted with a number of common anticonvulsants. Carbamazepine reduces blood plasma concentrations of<unk> , probably because it induces glucuronidation. This drug combination also increased the risk for diplopia, impaired coordination and dizziness in a clinical study. Phenytoin also reduces<unk>  plasma concentrations, which may be due to increased glucuronidation of<unk> ; and concomitant administration results in an increase in phenytoin serum concentrations, which is probably due to inhibition of CYP2C19. Combinations with lamotrigine, topiramate, valproic acid or levetiracetam showed no significant interactions in studies, although<unk>  has been shown to cause a minor reduction in lamotrigine levels.
Eslicarbazepine acetate
Propazepine
Carbamazepine
Oxcarbazepine
Nitroxazepine
Capsazepine
Zonisamide
Lamotrigine