Due to an insufficient capacity of subcutaneous adipose tissue to store fat, fat is deposited in non-adipose tissue (lipotoxicity), leading to insulin resistance. Patients display hypertriglyceridemia, severe fatty liver disease and little or no adipose tissue. Average patient lifespan is approximately 30 years before death, with liver failure being the usual cause of death. In contrast to the high levels seen in non-alcoholic fatty liver disease associated with obesity, leptin levels are very low in lipodystropy.
symptom of Cushing's syndrome
symptom of Klinefelter syndrome
symptom of Graves' disease
symptom of Hashimoto's thyroiditis
symptom of Hypothyroidism
symptom of Kallmann syndrome
symptom of Type 1 diabetes
symptom of Pheochromocytoma