There are three basic categories of drug<unk>  that can be used when a medication course is found to be ineffective. One option is to switch the patient to a different medication. Another option is to add a medication to the patient’s current<unk> . This can include combination therapy: the combination of two different types of antidepressants, or augmentation therapy: the addition of a non-antidepressant medication that may increase the effectiveness of the antidepressant. Medication Antidepressants Dose increase Increasing the dosage of an antidepressant is a common strategy to treat depression that does not respond after adequate<unk>  duration. Practitioners who use this strategy will usually increase the dose until the person reports intolerable side effects, symptoms are eliminated, or the dose is increased to the limit of what is considered safe. Switching antidepressants Studies have shown a wide variability in the effectiveness of switching antidepressants, with anywhere from 25–70% of people responding to a different antidepressant. There is support for the effectiveness of switching people to a different SSRI; 50% of people that were non-responsive after taking one SSRI were responsive after taking a second type. Switching people with<unk>  to a different class of antidepressants may also be effective. People who are non-responsive after taking an SSRI may respond to moclobemide or tricyclic antidepressants, bupropion or an MAOI. However, the more antidepressants an individual had already tried, the less likely they were to benefit from a new antidepressant trial. Some off label antidepressants are low dose ketamine and highly serotonergic catecholamines (including very controlled use of MDMA in the<unk>  of PTSD and crippling depression/anxiety). For lethargic syndromes, dysthymia, or caffeine-resistant amotivation, a dopaminergic stimulant such as methlyphenidate, or even dextroamphetamine or methamphetamine can be helpful. Primarily dopaminergic or norepinephrine releasing stimulants, in low doses, have been used especially in the past, or in conjunction with a multidisciplinary therapy approach, although more targeted and "mild" agents, including modafinil and atomoxetine are considered first line for both childhood and adult lethargy and inattention disorders, due to their virtually nonexistent abuse potential (limited to one or two cases per 10 000), and higher selectivity, safety, and thus slightly broader therapeutic index. When depression is related or co-morbid to an inattention disorder, often ADHD, then both can be carefully managed with the same first line stimulant medication, typically both methylphenidate and lisdexamfetamine. Other medications Medications that have been shown to be effective in people with<unk>  include lithium, triiodothyronine, benzodiazepines, atypical antipsychotics, and stimulants. Adding lithium may be effective for people taking some types of antidepressants; it does not appear to be effective in patients taking SSRIs. Triiodothyroxine (T3) is a type of thyroid hormone and has been associated with improvement in mood and depression symptoms. Benzodiazepines may improve<unk>  by decreasing the adverse side effects caused by some antidepressants and therefore increasing patient compliance. Since the entry of olanzapine into psychopharmacology, many psychiatrists have been adding low dose olanzapine to antidepressants and other atypical antipsychotics such as aripiprazole and quetiapine. Eli Lilly, the company that sells both olanzapine and fluoxetine individually, has also released a combination formulation which contains olanzapine and fluoxetine in a single capsule. Some low to moderate quality evidence points to success in the short term (8–12 weeks) using mianserin (or antipsychotics cariprazine, olanzapine, quetiapine or ziprasidone) to augment antidepressant medications. These have shown promise in treating refractory depression but come with serious side effects. Stimulants such as amphetamines and methylphenidate have also been tested with positive results but have potential for abuse. However, stimulants have been shown to be effective for the unyielding depressed combined lacking addictive personality traits or heart problems. Ketamine has been tested as a rapid-acting antidepressant for<unk>  in bipolar disorder, and major depressive disorder. Research A 2016 placebo randomized controlled trial evaluated the rapid antidepressant effects of the psychedelic ayahuasca in<unk>  with positive outcome. Physical psychiatric<unk> s Electroconvulsive therapy Electroconvulsive therapy is generally only considered as a<unk>  option in severe cases of<unk> . It is used when medication has repeatedly failed to improve symptoms, and usually when the patient’s symptoms are so severe that they have been hospitalized. Electroconvulsive therapy has been found to reduce thoughts of suicide and relieve depressive symptoms. It is associated with an increase in glial cell line derived neurotrophic factor. rTMS rTMS (repetitive transcranial magnetic stimulation) is gradually becoming recognised as a valuable therapeutic option in<unk> . A number of randomised placebo-controlled trials have compared real versus sham rTMS. These trials have consistently demonstrated the efficacy of this<unk>  against major depression. There have also been a number of meta-analyses of RCTs confirming the efficacy of rTMS in<unk><unk>  major depression, as well as naturalistic studies showing its effectiveness in "real world" clinical settings. dTMS dTMS (deep transcranial magnetic stimulation) is a continuation of the same idea as rTMS, but with the hope that deeper stimulation of subcortical areas of the brain leads to increased effect. A 2015 systematic review and health technology assessment found lacking evidence in order to recommend the method over either ECT or rTMS because so few studies had been published. Psychotherapy There is sparse evidence on the effectiveness of psychotherapy in cases of<unk> . However, a review of the literature suggests that it may be an effective<unk>  option. Psychotherapy may be effective in people with<unk>  because it can help relieve stress that may contribute to depressive symptoms. A Cochrane systematic review has shown that psychological therapies (including cognitive behavioural therapy, dialectal behavioural therapy, interpersonal therapy and intensive short-term dynamic psychotherapy) added to usual care (with antidepressants) can be beneficial for depressive symptoms and for response and remission rates over the short term (up to six months) for patients with<unk> . Medium‐ (7–12 months) and long‐term (longer than 12 months) effects seem similarly beneficial. Psychological therapies added to usual care (antidepressants) seem as acceptable as usual care alone.
Treatment-resistant depression
Long-term depression
Recurrent brief depression
Outline of bipolar disorder
Chronic hallucinatory psychosis
Double depression
Mass psychogenic illness
Late life depression