<unk>  does not have acute toxicity. In animal studies, the lowest found was 2.5-4.5 g/kg. In rats, the LD50 is ≥2300 mg/kg, and doses of 500 mg/kg/day over 2 years caused no detectable differences in survival rate, growth, or incidence of tumors. The metabolites of<unk>  also lack toxicity. The breakdown products of<unk>  under various storage conditions may have a lower LD50 than<unk> , but in all cases, the numbers are quite high. In humans, a dose of 500 mg/kg/day repeated over multiple days caused nausea, vomiting, and diarrhea. No evidence shows<unk> , at either pharmacological levels or levels encountered as a food additive, can harm normal intestinal flora, but definitive research may not be available. However, some people are allergic to<unk> . The EFSA has concluded that the use of<unk>  as a food additive has no relevant risk for the development of resistant fungi.
Natamycin
Capreomycin
Meropenem
Anisomycin
Erythromycin
Sideromycin
Clarithromycin
Paromomycin