<unk> <unk>  is produced in the gonads, pituitary gland, placenta, and other organs: * In the ovarian follicle,<unk>  increases FSH binding and FSH-induced aromatization. It participates in androgen synthesis enhancing LH action in the ovary and testis. In the male,<unk>  enhances spermatogenesis. *<unk>  is strongly expressed in wounded skin, and overexpression of<unk>  in epidermis of transgenic mice improves wound healing and enhances scar formation. Its action in wound repair and skin morphogenesis is through stimulation of keratinocytes and stromal cells in a dose-dependent manner. *<unk>  also regulates the morphogenesis of branching organs such as the prostate, lung, and especially kidney.<unk>  A increased the expression level of type-I collagen suggesting that<unk>  A acts as a potent activator of fibroblasts. * Lack of<unk>  during development results in neural developmental defects. *Upregulation of<unk>  A drives pluripotent stem cells into a mesoendodermal fate, and thus provides a useful tool for stem cell differentiation and organoid formation.<unk>  In both females and males,<unk> <unk> s FSH production.<unk>  does not<unk>  the secretion of GnRH from the hypothalamus. However, the overall mechanism differs between the sexes: In females<unk>  is produced in the gonads, pituitary gland, placenta, corpus luteum and other organs. FSH stimulates the secretion of<unk>  from the granulosa cells of the ovarian follicles in the ovaries. In turn,<unk>  suppresses FSH. *<unk>  B reaches a peak in the early- to mid-follicular phase, and a second peak at ovulation. *<unk>  A reaches its peak in the mid-luteal phase.<unk>  secretion is diminished by GnRH, and enhanced by insulin-like growth factor-1 (IGF-1). In males It is secreted from the Sertoli cells, located in the seminiferous tubules inside the testes. Androgens stimulate<unk>  production; this protein may also help to locally regulate spermatogenesis.
Activin and inhibin
Estrone/progesterone/testosterone
Estradiol/progesterone
Estrone/progesterone
SUSPUP and SUSPPUP
Estradiol/estrone/estriol
UPMC Central Pa
IPP-SHR