Treatment and survival is determined, to a great extent, by whether or not a cancer remains localized or spreads to other locations in the body. If the cancer<unk> es to other tissues or organs it usually dramatically increases a patient's likelihood of death. Some cancers—such as some forms of leukemia, a cancer of the blood, or malignancies in the brain—can kill without spreading at all. Once a cancer has<unk> ed it may still be treated with radiosurgery, chemotherapy, radiation therapy, biological therapy, hormone therapy, surgery, or a combination of these interventions ("multimodal therapy"). The choice of treatment depends on many factors, including the type of primary cancer, the size and location of the<unk> , the patient's age and general health, and the types of treatments used previously. In patients diagnosed with CUP it is often still possible to treat the disease even when the primary tumor cannot be located. Current treatments are rarely able to cure<unk> astatic cancer though some tumors, such as testicular cancer and thyroid cancer, are usually curable. Palliative care, care aimed at improving the quality of life of people with major illness, has been recommended as part of management programs for<unk> . Results from a systematic review of the literature on radiation therapy for brain<unk>  found that there is little evidence to inform comparative effectiveness and patient-centered outcomes on quality of life, functional status, and cognitive effects.
Metastasis
Diastasis 
Gliosis
Mixed tumor
Stoma 
Lymphatogenous metastasis
Vascular tumor
Tumor progression