An overdose of<unk>  can lead to fatigue, hypotension, hypoglycemia, bronchospasms, and bradycardia. Bronchospasms and hypoglycemia occur because at high doses, the drug can be an antagonist for β2 adrenergic receptors located in the lungs and liver. Bronchospasm occurs due to the blockage of β2 receptors in the lungs. Hypoglycemia occurs due to decreased stimulation of glycogenolysis and gluconeogenesis in the liver via β2 receptors. Cautions Beta-blockers should generally be avoided in people with a history of asthma or bronchospasm as they may worsen the disease. A beta 1 selective beta-blocker like<unk>  may be cautiously tried in those with controlled, mild-to-moderate asthma with cardiac comorbidities. A 2014 meta-analysis found that cardioselective beta-blockers may cause detrimental changes in lung function and partially blunts b2-agonist response. However, a 2017 control study found no significant association with asthma exacerbations by dose and exposure duration while a 2020 clinical trial found<unk>  being non-inferior to placebo in bronchodilator response to salbutamol.
Bisoprolol
Metoprolol
Sotalol
Digoxin
Carvedilol
Digitoxin
Amiodarone
Diltiazem