Platelet<unk>  can be due to immune causes or non-immune causes. Non-immune causes account for over 80% of cases of platelet<unk> , and sepsis is one of the most common non-immune causes. HLA alloimmunization is the commonest immune cause of platelet<unk> . Non-immune causes Patient-related * Sepsis * Fever * Disseminated intravascular coagulation * Splenomegaly * Treatment of infection, antibiotics (vancomycin), antifungals (amphotericin B) * Graft-versus-host disease * Hepatic veno-occlusive disease * Bleeding Platelet component-related * Age of platelet component * ABO mismatch between platelet component and recipient * Number of platelets within the component if platelet increment (PI) is used to calculate platelet<unk>  * Pathogen-reduced platelet component Immune causes * Alloantibodies to platelet antigens * Human leucocyte antigen (HLA) antibodies * Human platelet antigen (HPA) antibodies * Immune complexes * Other antibodies * Drug-related antibodies
Platelet transfusion refractoriness
Pseudothrombocytopenia
COAT platelet defect
Platelet storage pool deficiency
Mechanical hemolytic anemia
Reticulocytopenia
Febrile non-hemolytic transfusion reaction
Transfusion-dependent anemia