<unk> otic leg wound caused by a brown recluse spider bite<unk>  may occur due to external or internal factors. External factors External factors may involve mechanical trauma (physical damage to the body which causes cellular breakdown), damage to blood vessels (which may disrupt blood supply to associated tissue), and ischemia. Thermal effects (extremely high or low temperature) can result in<unk>  due to the disruption of cells. In frostbite, crystals form, increasing the pressure of remaining tissue and fluid causing the cells to burst. Under extreme conditions tissues and cells die through an unregulated process of destruction of membranes and cytosol. Internal factors Internal factors causing<unk>  include: trophoneurotic disorders (diseases that occur due to defective nerve action in a part of an organ which results in failure of nutrition); injury and paralysis of nerve cells. Pancreatic enzymes (lipases) are the major cause of fat<unk> .<unk>  can be activated by components of the immune system, such as the complement system; bacterial toxins; activated natural killer cells; and peritoneal macrophages. Pathogen-induced<unk>  programs in cells with immunological barriers (intestinal mucosa) may alleviate invasion of pathogens through surfaces affected by inflammation. Toxins and pathogens may cause<unk> ; toxins such as snake venoms may inhibit enzymes and cause cell death.<unk> otic wounds have also resulted from the stings of Vespa mandarinia. Pathological conditions are characterized by inadequate secretion of cytokines. Nitric oxide (NO) and reactive oxygen species (ROS) are also accompanied by intense<unk> otic death of cells. A classic example of a<unk> otic condition is ischemia which leads to a drastic depletion of oxygen, glucose, and other trophic factors and induces massive<unk> otic death of endothelial cells and non-proliferating cells of surrounding tissues (neurons, cardiomyocytes, renal cells, etc.). Recent cytological data indicates that<unk> otic death occurs not only during pathological events but it is also a component of some physiological process. Activation-induced death of primary T lymphocytes and other important constituents of the immune response are caspase-independent and<unk> otic by morphology; hence, current researchers have demonstrated that<unk> otic cell death can occur not only during pathological processes, but also during normal processes such as tissue renewal, embryogenesis, and immune response.
Necrosis
Demineralization 
Desquamation
Degeneration 
Tissue expansion
Remyelination
Granulation
Cell death