Sources for incidence lists: ;Very common (>10% incidence) adverse effects * Dry mouth * Dizziness * Headache * Somnolence (drowsiness; of 15 antipsychotics<unk>  causes the 5th most sedation. Extended release (XR) formulations tend to produce less sedation, dose-by-dose, than the immediate release formulations.) ;Common (1–10% incidence) adverse effects * High blood pressure * Orthostatic hypotension * High pulse rate * High blood cholesterol * Elevated serum triglycerides * Abdominal pain * Constipation * Increased appetite * Vomiting * Increased liver enzymes * Backache * Asthenia * Insomnia * Lethargy * Tremor * Agitation * Nasal congestion * Pharyngitis * Fatigue * Pain * Dyspepsia (Indigestion) * Peripheral oedema * Dysphagia * Extrapyramidal disease:<unk>  and clozapine are noted for their relative lack of extrapyramidal side effects. * Weight gain: SMD 0.43 kg when compared to placebo. Produces roughly as much weight gain as risperidone, less weight gain than clozapine, olanzapine and zotepine and more weight gain than ziprasidone, lurasidone, aripiprazole and asenapine. As with many other atypical antipsychotics, this action is likely due to its actions at the H1 histamine receptor and 5-HT2C receptor. ;Rare (<1% incidence) adverse effects * Prolonged QT interval (had an odds ratio for prolonging the QT interval over placebo of 0.17) * Sudden cardiac death * Syncope * Diabetic ketoacidosis * Restless legs syndrome * Hyponatraemia, low blood sodium. * Jaundice, yellowing of the eyes, skin and mucous membranes due to an impaired ability of the body to clear bilirubin, a by product of haem breakdown. * Pancreatitis, pancreas swelling. * Agranulocytosis, a potentially fatal drop in white blood cell count. * Leukopenia, a drop in white blood cell count, not as severe as agranulocytosis. * Neutropenia, a drop in neutrophils, the cell of the immune cells that defends the body against bacterial infections. * Eosinophilia * Anaphylaxis, a potentially fatal allergic reaction. * Seizure * Hypothyroidism, underactive thyroid gland. * Myocarditis, swelling of the myocardium. * Cardiomyopathy * Hepatitis, swelling of the liver. * Suicidal ideation * Priapism. A prolonged and painful erection. * Stevens–Johnson syndrome. A potentially fatal skin reaction. * Neuroleptic malignant syndrome a rare and potentially fatal complication of antipsychotic drug treatment. It is characterised by the following symptoms: tremor, rigidity, hyperthermia, tachycardia, mental status changes (e.g. confusion), etc. * Tardive dyskinesia. A rare and often irreversible neurological condition characterised by involuntary movements of the face, tongue, lips and rest of the body. Most commonly occurs after prolonged treatment with antipsychotics. It is believed to be particularly uncommon with atypical antipsychotics, especially<unk>  and clozapine Both typical and atypical antipsychotics can cause tardive dyskinesia. According to one study, rates are lower with the atypicals at 3.9% as opposed to the typicals at 5.5%. Although<unk>  and clozapine are atypical antipsychotics, switching to these atypicals is an option to minimize symptoms of tardive dyskinesia caused by other atypicals. Weight gain can be a problem for some, with<unk>  causing more weight gain than fluphenazine, haloperidol, loxapine, molindone, olanzapine, pimozide, risperidone, thioridazine, thiothixene, trifluoperazine, and ziprasidone, but less than chlorpromazine, clozapine, perphenazine, and sertindole. As with some other anti-psychotics,<unk>  may lower the seizure threshold, and should be taken with caution in combination with drugs such as bupropion. Discontinuation The British National Formulary recommends a gradual withdrawal when discontinuing antipsychotics to avoid acute withdrawal syndrome or rapid relapse. Symptoms of withdrawal commonly include nausea, vomiting, and loss of appetite. Other symptoms may include restlessness, increased sweating, and trouble sleeping. Less commonly there may be a feeling of the world spinning, numbness, or muscle pains. Symptoms generally resolve after a short period of time. There is tentative evidence that discontinuation of antipsychotics can result in psychosis. It may also result in reoccurrence of the condition that is being treated. Rarely tardive dyskinesia can occur when the medication is stopped. Pregnancy and lactation Placental exposure is least for<unk>  compared to other atypical antipsychotics. The evidence is insufficient to rule out any risk to the foetus but available data suggests it is unlikely to result in any major foetal malformations. It is secreted in breast milk and hence<unk> -treated mothers are advised not to breastfeed. Abuse potential In contrast to most other antipsychotic drugs, which tend to be somewhat aversive and often show problems with patient compliance with prescribed medication regimes,<unk>  is sometimes associated with drug misuse and abuse potential, for its hypnotic and sedative effects. It has a limited potential for misuse, usually only in individuals with a history of polysubstance abuse and/or mental illness, and especially in those incarcerated in prisons or secure psychiatric facilities where access to alternative intoxicants is more limited. To a significantly greater extent than other atypical antipsychotic drugs,<unk>  was found to be associated with drug-seeking behaviors, and to have standardised street prices and slang terms associated with it, either by itself or in combination with other drugs (such as "Q-ball" for the intravenous injection of<unk>  mixed with cocaine). The pharmacological basis for this distinction from other second generation antipsychotic drugs is unclear, though it has been suggested that<unk> 's comparatively lower dopamine receptor affinity and strong antihistamine activity might mean it could be regarded as more similar to sedating antihistamines in this context. While these issues have not been regarded as sufficient cause for placing<unk>  under increased legal controls, prescribers have been urged to show caution when prescribing<unk>  to individuals with characteristics that might place them at increased risk for drug misuse.
Quetiapine
Sertraline
Mirtazapine
Fluparoxan
Asenapine
Aripiprazole
Citalopram
Loxapine