<unk>  is a drug for the treatment of hepatitis C that was developed by Gilead Sciences. After completing Phase III clinical trials, on February 10, 2014, Gilead filed for U.S. approval of a<unk> /sofosbuvir fixed-dose combination tablet for genotype 1 hepatitis C. The<unk> /sofosbuvir combination is a direct-acting antiviral agent that interferes with HCV replication and can be used to treat patients with genotypes 1a or 1b without PEG-interferon or ribavirin.<unk>  is an inhibitor of NS5A, a hepatitis C virus protein. Data presented at the 20th Conference on Retroviruses and Opportunistic Infections in March 2013 showed that a triple regimen of the nucleotide analog inhibitor sofosbuvir,<unk> , and ribavirin produced a 12-week post-treatment sustained virological response (SVR12) rate of 100% for both treatment-naive patients and prior non-responders with HCV genotype 1. The sofosbuvir/ledipasvir coformulation is being tested with and without ribavirin. In February 2014 Gilead filed for United States Food and Drug Administration (FDA) approval of<unk> /sofosbuvir oral treatment, without interferon and ribavirin. On 10 October 2014 the FDA approved the combination product<unk> /sofosbuvir called Harvoni.
Ledipasvir
Telaprevir
Odalasvir
Ombitasvir
Glecaprevir
Paritaprevir
Saquinavir
Enfuvirtide