<unk>  (AKA hereditary<unk>  is a disease caused by an enzyme deficiency resulting in a decreased ability to synthesize pyrimidines. It was the first described enzyme deficiency of the de novo pyrimidine synthesis pathway.<unk>  is characterized by excessive excretion of<unk>  acid in urine because of the inability to convert<unk>  acid to UMP. It causes megaloblastic anemia and may be associated with mental and physical developmental delays.
Orotic aciduria
Lysinuric protein intolerance
Hawkinsinuria
Urocanic aciduria
Xanthinuria
Pentosuria
Alkaptonuria
Glycosuria