The<unk> s were first defined in 2008 and have not yet been determined to have any roles in human physiology or pathology. However, their production is stimulated in human<unk> ophils by physiological agonists such as prostaglandin D2, leukotriene C4, and interleukin 5. Furthermore,<unk> s stimulate vascular permeability in an ex vivo human vascular endothelial model system, and in a small study of 32 volunteers EXC4 production by<unk> ophils isolated from severe and aspirin-intolerant asthmatics was greater than that from healthy volunteers and mild asthmatic patients. These findings have led to suggestions that<unk> s have pro-inflammatory actions and are involved in severe asthma, aspirin-induced asthma attacks, and perhaps other allergic reactions. A subsequent study found that<unk>  levels in the exhaled breath of aspirin-sensitive and aspirin-intolerant asthmatic individuals did not rise after aspirin challenge and did not correlate with disease severity. The production of<unk> s by Reed-Sternburg cells has also led to suggestion that they are involve in the lymphoma of Hodgkins disease and, possibly, prostate cancer, colon cancer, and other cancer types.
Eoxin
Toxin
Toxicophore
Chlorotoxin
Allergen
Aeroallergen
Agitoxin
Aflatoxin