In the US,<unk>  is approved for the treatment of opioid induced constipation in adults with chronic non-cancer pain, including those who have chronic pain related to prior cancer or its treatment and do not need frequent opioid dosage escalation. In the European Union,<unk>  is also approved for the treatment of opioid induced constipation in adults, but as a second-line therapy after treatment with a laxative.
Naldemedine
Avacopan
Clopenthixol
Levomepromazine
Acetomepregenol
Dihydroergotamine
Alosetron
Ephedrine