Symptoms of JPLS begin in early childhood and progress over a period of 15 to 20 years. Early symptoms include clumsiness, muscle spasms, weakness and stiffness in the legs, and difficulty with balance. As symptoms progress, they become more serious and include weakness and stiffness in the arms and hands, slurred speech, drooling, difficulty swallowing, and an inability to walk.
Juvenile primary lateral sclerosis
Primary lateral sclerosis
Amyotrophic lateral sclerosis
Tumefactive multiple sclerosis
CMV polyradiculomyelopathy
Paraneoplastic cerebellar degeneration
Viliuisk encephalomyelitis
Bickerstaff brainstem encephalitis