<unk> , also known as Uncharacterized<unk>  C1orf173, is a<unk>  encoded by the ERICH3 gene. ERICH3 was named “chromosome 1 open reading frame 173 (C1orf173)” based on its map location in the human genome. It was subsequently renamed “E-rich<unk> ” as a result of the high content of<unk>  (E) in its encoded amino acid sequence. Single-nucleotide polymorphisms (SNPs) in the ERICH3 gene has been identified as one of the "top" signals in a genome-wide association study (GWAS) for plasma serotonin concentrations which were themselves associated with selective serotonin reuptake inhibitor (SSRI) response in major depressive disorder (MDD) patients. The same ERICH3 SNP was later demonstrated that was significantly associated with SSRI treatment outcomes in three independent MDD trials, including STAR*D, ISPC and PReDICT. ERICH3 is most highly expressed in a variety of regions of the human brain, including the nucleus accumbens (basal ganglia) and frontal cortex based on the GTEx RNA-seq data. The single-cell RNA-seq data for human brain samples revealed that ERICH3 is predominantly expressed in neurons rather than other CNS cell types. ERICH3 was found interacts with<unk> s function in vesicle biogenesis and may play a significant role in vesicular function in serotonergic and other neuronal cell types, which might help explain its association with antidepressant treatment response. ERICH3<unk>  was also found abundant in blood platelets and cilia based on the proteomic studies. Its function in platelet was thought related to plasma serotonin storage because more than 99% of blood serotonin was stored in platelet and ERICH3 SNPs has been associated with plasma serotonin concentration in MDD patients. ERICH3 in primary cilia might regulates cilium formation and the localizations of ciliary transport.
Glutamate-rich protein 3
Neurofilament light polypeptide
Tetraspanin
Peripheral myelin protein 22
Retapamulin
Peripherin
Cerebrolysin
Pedialyte