Second generation cephalosporins are more effective in treating Gram-negative bacilli compared to first generation cephalosporins, which have a greater coverage for Gram-positive cocci. Also, it has been reported that<unk>  is resistant to hydrolysis by β-lactamases produced by Gram-negative bacteria. Some medical uses are: * Upper respiratory tract infections. * Lower respiratory tract infections. * Urinary tract infections. * Skin and soft tissue infections. * Gonorrhoea. * Early Lyme disease. Bacterial susceptibility<unk>  treats infections against methicillin, oxacillin and penicillin-sensitive bacterial strains.<unk>  does not work against enterococci. Gram-positive aerobic microorganisms * Staphylococcus aureus (Methicillin-sensitive only) * Staphylococcus epidermis * Streptococcus pneumoniae (Penicillin-sensitive only) Gram-negative aerobic microorganisms * Haemophilus influenzae * Moraxella catarrhalis * Neisseria gonorrhoeae * Escherichia coli * Proteus mirabilis * Klebsiella pneumoniae (variable activity)
Cefuroxime axetil
Imipenem/cilastatin
Imipenem/cilastatin/relebactam
Amoxicillin/clavulanic acid
Ceftazidime/avibactam
Avibactam
Ceftolozane/tazobactam
Azithromycin