<unk> , also known as<unk>  syndrome, G syndrome or<unk>  syndrome, is a rare genetic disorder that will affect physical structures along the midline of the body. The letters G and<unk>  represent the last names of the families that were first diagnosed with the disorder, while<unk>  is the last name of the doctor that first described the signs and symptoms of the disease. There are two different forms of Optiz G/BBB syndrome: x-linked (recessive) syndrome (Type I; XLOS; OSX) and dominant autosomal syndrome (Type II; ADOS). However, both result in common physical deformities, although their pattern of inheritance may differ. Several other names for the disease(s) are no longer used. These include hypospadias-dysphagia syndrome,<unk> -Frias syndrome, telecanthus with associated abnormalities, and hypertelorism-hypospadias syndrome. One out of every 50,000 to 100,000 males is born with X-linked type II Optiz G/BBB syndrome, but professionals believe that condition is under diagnosed and there are actually many more cases. It is unknown as to how many autosomal dominant cases exist. However, the autosomal dominant cases are also categorized under a more commonly diagnosed group called 22q11.2 deletion syndrome. This group includes several other diseases that all result because of a small deletion of chromosome 22 at the q11.2 location.
Opitz G/BBB syndrome
Lown–Ganong–Levine syndrome
Long QT syndrome
Buschke–Ollendorff syndrome
Carney's triad
Short QT syndrome
Pacak–Zhuang syndrome
Pascual-Castroviejo syndrome type 1