PT-DBCL is by far the most common form of<unk>  cancer in men >60 years of age. It usually develops in this age group (median age ~65 years old, range 10–96 years) and presents as a painless<unk>  mass or swelling in one testis or, in ~6% of cases, both testes: PT-DLBCL is the most common<unk>  cancer to present with disease in both testicles. About 30-40% of afflicted individuals present concurrently with hydrocele testis, i.e. an enlarged testis due to the accumulation of clear fluid. The tumors commonly increase in size at a rapid pace, may advance locally to involve the epididymis, spermatic cord, scrotal skin, and/or regional lymph nodes, and may cause sharp scrotal pain. About 10% to 33% of individuals have B symptoms such as fever, night sweats, and weight loss. Initial laboratory studies show increases in serum lactate dehydrogenase levels in a third of cases. Some 80% of individuals present with either localized Ann Arbor stage I or locally advanced Ann Arbor stage II disease. The remaining ~20% of cases have disseminated Ann Arbor stage III or IV disease that has spread to the abdominal lymph nodes, Waldeyr's ring of lymphoid tissue that surrounds the nasopharynx and oropharynx, contralateral testis, skin, lung, and, most seriously, the parenchyma of and/or the leptomembranes surrounding either the brain or spinal cord.
Primary testicular diffuse large B-cell lymphoma
Testicular sarcoidosis
Transitional cell carcinoma of the ovary
Renal medullary fibroma
Renal anaplastic sarcoma
Metanephric adenoma
Multilocular cystic renal cell carcinoma
Renal cell carcinoma with t