Genetically,<unk>  has been associated with a few unusual genetic characteristics. Among them, it is associated with a particular genetic variant of the human leukocyte antigen called HLA-DR7. This variant is normally present in 26% in the Caucasian population. Chromosome analysis has detected an isochromosome +i(3q), with or without premature chromosome condensation. Also, a t(14;18)(q22;21) bcl-2/IgH rearrangement has been described, as usually seen in follicular lymphoma. Immunologically, peripheral B-cells show more functional IgD+ positive CD27 cells than usual.
Persistent polyclonal B-cell lymphocytosis
Chronic active EBV infection
Monoclonal B-cell lymphocytosis
Persistent generalized lymphadenopathy
Lymphoid neoplasms with plasmablastic differentiation
Thymoma-associated multiorgan autoimmunity
Progressive transformation of germinal centres
Immunodeficiency with hyperimmunoglobulin M