The contraindications of<unk>  are largely the same as those of estradiol and include: * Hypersensitivity to<unk> , mepivacaine, or other ingredients * Known, previous, or suspected breast cancer or other estrogen-dependent malignant tumors (e.g., endometrial cancer) * Vaginal bleeding of unknown cause or untreated endometrial hyperplasia * Thrombosis and related, including active thrombophlebitis, former or current venous thromboembolism (deep vein thrombosis, pulmonary embolism), active or recent arterial thromboembolism (e.g., angina, myocardial infarction), or known thrombophilia (e.g., protein C deficiency, protein S deficiency, antithrombin deficiency) * Severe arrhythmia, hypotension, hypertension, or lipid metabolism disorders * Cerebrovascular events (i.e., stroke) * Acute liver disease or previously confirmed liver disease, with abnormal liver function tests or jaundice (e.g., Dubin–Johnson syndrome, Rotor syndrome) * Severe hepatic dysfunction * Others including porphyria, sickle cell anemia, otosclerosis, or myasthenia gravis * Pregnancy, lactation, and breastfeeding
Polyestradiol phosphate
Polyestriol phosphate
Progestogen ester
Androgen ester
Progestogen 
Progestogen
Estradiol sulfate
Estrogen ester