<unk>  <unk>  is a mitochondrially inherited (transmitted from mother to offspring) degeneration of retinal ganglion cells (RGCs) and their axons that leads to an acute or subacute loss of central vision; it predominantly affects young adult males.<unk>  is transmitted only through the mother, as it is primarily due to mutations in the mitochondrial (not nuclear) genome, and only the egg contributes mitochondria to the embryo.<unk>  is usually due to one of three pathogenic mitochondrial DNA (mtDNA) point mutations. These mutations are at nucleotide positions 11778 G to A, 3460 G to A and 14484 T to C, respectively in the ND4, ND1 and ND6 subunit genes of complex I of the oxidative phosphorylation chain in mitochondria. Men cannot pass on the disease to their offspring.
Leber's hereditary optic neuropathy
Kjer's optic neuropathy
Alexander disease
Graves' ophthalmopathy
Bosch-Boonstra-Schaaf optic atrophy syndrome
Sorsby's fundus dystrophy
Neuromyelitis optica spectrum disorder
Akureyri disease