Evidence for benefit of<unk>  is mixed, with some evidence for use in certain conditions and against use in other conditions. It has been investigated for chronic tendinitis, osteoarthritis, in oral surgery, and in plastic surgery. A 2019 review found it not to be useful in rotator cuff disease. While an older review found that it may be useful. Tentative evidence supports its use in osteoarthritis (OA) of the knee. A 2019 meta-analysis found that<unk>  might be more effective in reducing pain and improving function than hyaluronic acid in knee OA. A 2009 review found few randomized controlled trials that adequately evaluated the safety and efficacy of<unk>  treatments and concluded that<unk>  was "a promising, but not proven, treatment option for joint, tendon, ligament, and muscle injuries". As compared to other conservative treatments for non-surgical orthopedic illnesses (e.g. steroid injection for plantar fasciitis), evidence does no support the use of<unk>  as a conservative treatment. A 2018 review found that evidence was lacking for Achilles tendinopathy. A 2019 meta-analysis found that, for most outcomes in Achilles tendinopathy,<unk>  treatment did not differ from placebo treatment. A 2010 Cochrane review of use in sinus lifts during dental implant placement found no evidence of benefit. A 2013 review stated more evidence was needed to determine effectiveness for hair regrowth. A 2014 Cochrane review of<unk>  in musculoskeletal injuries found very weak evidence for a decrease in pain in the short term, and no difference in function in the short, medium or long term. There was weak evidence that suggested that harm occurred at comparable, low rates in treated and untreated people. Similarly, another 2017 review for treating pain on skin graft donor sites found the evidence for benefit was poor. It has not been shown to be useful for bone healing. A 2016 review of<unk>  use to augment bone graft found only one study reporting a difference in bone augmentation, while four studies found no difference. Besides the use in clinical practice<unk>  has been utilized for various tissue engineering applications in the context of bone, cartilage, skin, and soft tissue repair. It has been reviewed to serve as a source for the "delivery of growth factors and/or cells within tissue-engineered constructs, often in combination with biomaterials".
Platelet-rich plasma
Recombinant factor VIIa
Prothrombin complex concentrate
Protamine
Cryoprecipitate
Protamine sulfate
Fresh frozen plasma
Aminocaproic acid