Pathogenesis of IgA Deficiency ‘In IgA-deficient patients, the common finding is a maturation defect in B cells to produce IgA’. ‘In IgA deficiency, B cells express IgA; however, they are of immature phenotype with the coexpression of IgM and IgD, and they cannot fully develop into IgA-secreting plasma cells’. There is an inherited inability to produce<unk>  A (IgA), a part of the body's defenses against infection at the body's surfaces (mainly the surfaces of the respiratory and digestive systems). As a result, bacteria at these locations are somewhat more able to cause disease. Types include: Type OMIM Gene Locus IGAD1 Unknown; MSH5 suggested 6p21 IGAD2 TNFRSF13B 17p11
Selective immunoglobulin A deficiency
Isolated primary immunoglobulin M deficiency
Primary immunodeficiency
IgG deficiency
X-linked agammaglobulinemia
Transient hypogammaglobulinemia of infancy
Chronic granulomatous disease
Combined immunodeficiencies