Pharmacodynamics +<unk>  Site Ki (nM) Species Ref >10,000 (IC50) Rat ' 220 (IC50) Rat >10,000 (IC50) Rat 5-HT1A 5-HT2A 5-HT2C α1 α2 24.3 (IC50) Rat H1 Values are Ki (nM), unless otherwise noted. The smaller the value, the more strongly the drug binds to the site.<unk>  acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2 subtypes, as well as an H1 receptor inverse agonist/antihistamine.
Setiptiline
Verapamil
Tocainide
Procainamide
Ivabradine
Veratridine
Flecainide
Lofexidine