Eighty to ninety percent of those with<unk>  are unable to produce and keep fat tissue and have multiple lipomas. Other types of growths, including jaw tumours, may also occur. Approximately two thirds of individuals with<unk>  have intracranial and/or intraspinal lipomas. They also have an increased risk of developing a form of brain cancer known as a glioma. Other neurological issues that can occur include seizures, spasticity and variable intellectual disability. However, approximately one third of effected individuals have typical intelligence. The most common ocular abnormality in<unk>  is a form of benign growth called a choristoma which can occur in one or both eyes. These may effect vision. Other ocular symptoms include abnormally small eyes, small pupils, iris hypoplasia, sclerocornea, hypertrophic conjunctivae, an absent macular reflex and anterior chamber anomalies. There may be eyelid colobomas and short or abnormal palpebral fissures. Skin tags often grow around the eyelids.
Encephalocraniocutaneous lipomatosis
Acrocephalosyndactylia
Thanatophoric dysplasia
Pachydermoperiostosis
Acrofrontofacionasal dysostosis
Cleidocranial dysostosis
Trichodysplasia spinulosa
Sirenomelia