<unk>  is in the substituted methylenedioxyphenethylamine and substituted amphetamine classes of chemicals. As a free base,<unk>  is a colorless oil insoluble in water. The most common salt of<unk>  is the hydrochloride salt; pure<unk>  hydrochloride is water-soluble and appears as a white or off-white powder or crystal. Synthesis There are numerous methods available to synthesize<unk>  via different intermediates. The original<unk>  synthesis described in Merck's patent involves brominating safrole to 1-(3,4-methylenedioxyphenyl)-2-bromopropane and then reacting this adduct with methylamine. Most illicit<unk>  is synthesized using MDP2P (3,4-methylenedioxyphenyl-2-propanone) as a precursor. MDP2P in turn is generally synthesized from piperonal, safrole or isosafrole. One method is to isomerize safrole to isosafrole in the presence of a strong base, and then oxidize isosafrole to MDP2P. Another method uses the Wacker process to oxidize safrole directly to the MDP2P intermediate with a palladium catalyst. Once the MDP2P intermediate has been prepared, a reductive amination leads to racemic<unk>  (an equal parts mixture of (R)-MDMA and (S)-MDMA). Relatively small quantities of essential oil are required to make large amounts of<unk> . The essential oil of Ocotea cymbarum, for example, typically contains between 80 and 94% safrole. This allows 500 ml of the oil to produce between 150 and 340 grams of<unk> . Detection in body fluids<unk>  and MDA may be quantitated in blood, plasma or urine to monitor for use, confirm a diagnosis of poisoning or assist in the forensic investigation of a traffic or other criminal violation or a sudden death. Some drug abuse screening programs rely on hair, saliva, or sweat as specimens. Most commercial amphetamine immunoassay screening tests cross-react significantly with<unk>  or its major metabolites, but chromatographic techniques can easily distinguish and separately measure each of these substances. The concentrations of MDA in the blood or urine of a person who has taken only<unk>  are, in general, less than 10% those of the parent drug.
MDMA
Phencyclidine
Theobromine
Benzocaine
Heroin
Cocaine
Cocaine 
Amphetamine