If elevated lactate is present in acute illness, supporting the oxygen supply and blood flow are key initial steps. Some vasopressors (drugs that augment the blood pressure) are less effective when lactate levels are high, and some agents that stimulate the beta-2 adrenergic receptor can elevate the lactate further. Direct removal of lactate from the body (e.g. with hemofiltration or dialysis) is difficult, with limited evidence for benefit; it may not be possible to keep up with the lactate production. Limited evidence supports the use of sodium bicarbonate solutions to improve the pH (which is associated with increased carbon dioxide generation and may reduce the calcium levels). Lactic acidosis caused by inherited mitochondrial disorders (type B3) may be treated with a ketogenic diet and possibly with dichloroacetate (DCA), although this may be complicated by peripheral neuropathy and has a weak evidence base.
symptom of Pyruvate carboxylase deficiency
symptom of Glucose-6-phosphate dehydrogenase deficiency
symptom of Adenylosuccinate lyase deficiency
symptom of Phenylketonuria
symptom of Glycogen storage disease type III
symptom of Dubin–Johnson syndrome
symptom of Beta-mannosidosis
complications of Pyruvate carboxylase deficiency