Like most cancers, mutations in the DNA begin<unk>  development and lead to loss of function of white blood<unk> s. Different subtypes of leukemia have similarities in their causes, which are a combination of genetics, epigenetic changes, and environmental factors. However, because there are few<unk>  cases in comparison to other subtypes of leukemia, there is currently no clear cause of<unk> .<unk>  is not contagious nor inherited but specific genetic mutations, commonly including NOTCH1 and CDKN2A, may be passed along which increases susceptibility of<unk> . Causes of<unk>  Genetic conditions Some patients may have familial histories with leukemia predispositions which increases risk of developing<unk> . Li-Fraumeni syndrome is an inherited condition that leads to mutation of TP53, a tumor suppressor gene, which then increases risk of<unk> . Mutation in gene SPRED1 is also associated with development of<unk> . Patients with immature thymocytes in the thymus begins<unk>  development. Furthermore, hereditary conditions such as Down syndrome, neurofibromatosis type 1, ataxia telangiectasia, and Noonan syndrome are associated with higher risk of developing<unk> . Radiation exposure Human T-Lymphotropic Virus Those who have had pervious chemotherapy and exposure to radiation may have increased risks of developing<unk> . CDKN2A is an inherited polymorphism variant that is seen to be associated with development of<unk> . SR-90 emission from nuclear reactor accidents is also believed to increase risk of developing<unk> . Chemical exposure Benzene, a chemical classified as being carcinogenic to humans, is associated with increased risk of<unk> , as well as other forms of leukemia. Viruses Human T-Lymphotropic virus (HTLV-1) is a retroviral infection that affect white blood<unk> s (T<unk> s), which may later develop into<unk>  and other subtypes of leukemia.
T-Cell Acute Lymphoblastic Leukemia
T-lymphoblastic leukemia/lymphoma
Adult T-cell leukemia/lymphoma
Atypical chronic myeloid leukemia
T-cell acute lymphoblastic leukemia
Aggressive NK-cell leukemia
T-cell prolymphocytic leukemia
B-cell prolymphocytic leukemia