A blood bag for blood<unk> <unk>  is a form of anemia characterized by the need for continuous blood<unk> . It is a condition that results from various diseases, and is associated with decreased survival rates. Regular<unk>  is required to reduce the symptoms of anemia by increasing functional red blood cells and hemoglobin count. Symptoms may vary based on the severity of the condition and the most common symptom is fatigue. Various diseases can lead to<unk> , most notably Myelodysplastic syndromes (MDS) and thalassemia. Due to the number of diseases that can cause<unk> , diagnosing it is more complicated.<unk> <unk> e occurs when an average of more than 2 units of blood transfused every 28 days is required over a period of at least 3 months. Myelodysplastic syndromes is often only diagnosed when patients become anemic, and<unk><unk>  thalassemia is diagnosed based on gene mutations. Screening for heterozygosity in the thalassemia gene is an option for early detection. The<unk> s itself alleviates the symptoms of anemia, and are used to treat the disease that causes<unk> <unk> e. The recommended restrictive threshold for blood<unk>  is a hemoglobin level of 7 to 8 g/dL, while a more liberal threshold is set at 9 to 10 g/dL. However, more evidence may be required to establish a consensus on the threshold and a personalized approach may be more useful. The main complication of<unk> <unk> e is iron overloading, which can damage the liver, heart, bone tissue and endocrine glands. Iron chelation therapy is used to treat iron overload and common iron chelators used are deferoxamine, deferiprone and deferasirox. Due to the complications of<unk> s<unk> y, it may be more ideal to directly treat the cause of anemia if possible. However this might not be suitable for all patients, and some may still rely on frequent blood<unk> s for survival. While<unk>  has a poor prognosis, advancement in iron chelation therapy may help increase survival rates.
Transfusion-dependent anemia
Post-transfusion purpura
Acute hemolytic transfusion reaction
Acquired hemolytic anemia
Delayed hemolytic transfusion reaction
Acute posthemorrhagic anemia
Mixed autoimmune hemolytic anemia
Mechanical hemolytic anemia