Similar to doxorubicin,<unk>  interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription.<unk>  stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication. On binding to DNA,<unk> nomycin intercalates, with its<unk> nosamine residue directed toward the minor groove. It has the highest preference for two adjacent G/C base pairs flanked on the 5' side by an A/T base pair. Crystallography shows that<unk> nomycin induces a local unwinding angle of 8°, and other conformational disturbances of adjacent and second-neighbour base pairs. It can also induce histone eviction from chromatin upon intercalation.
Daunorubicin
Epirubicin
Valrubicin
Ifosfamide
Vincristine
Doxorubicin
Mitoxantrone
Etoposide