* Relief of heartburn * Short-term and maintenance therapy of gastric and duodenal ulcers * With nonsteroidal anti-inflammatory drugs (NSAIDs) to reduce the risk of ulceration Proton-pump inhibitors (PPIs) are more effective for the prevention of NSAID-induced ulcers. * Pathologic gastrointestinal (GI) hypersecretory conditions such as Zollinger–Ellison syndrome * Gastroesophageal reflux disease (GORD or GERD) * Erosive esophagitis * Part of a multidrug regimen for H. pylori eradication to minimise the risk of duodenal ulcer recurrence * Recurrent postoperative ulcer * Upper GI bleeding * For prevention of acid-aspiration pneumonitis during surgery, it can be administered preoperatively. The drug increases gastric pH, but generally has no effect on gastric volume. In a 2009 meta-analysis comparing the net benefit of PPIs and<unk>  to reduce the risk of aspiration before anaesthesia,<unk>  was found to be more effective than PPIs in reducing the volume of gastric secretions.<unk>  may have an anti-emetic effect when administered preoperatively. * Prevention of stress-induced ulcers in critically ill patients * Used together with diphenhydramine as secondary treatment for anaphylaxis; after first-line epinephrine. Dosing For ulcer treatment, a night-time dose is especially important, as the increase in gastric and duodenal pH promotes healing overnight, when the stomach and duodenum are empty. Conversely, for treating acid reflux, smaller and more frequent doses are more effective.<unk>  was originally administered long-term for acid-reflux treatment, sometimes indefinitely. For some, though, proton pump inhibitors (PPIs) have taken over this role. In addition, in children, a fairly rapid tachyphylaxis can develop within six weeks of initiation of treatment, further limiting its potential for long-term use. People with Zollinger–Ellison syndrome have been given very high doses without any harm.
Ranitidine
Azacitidine
Cimetidine
Lansoprazole
Dexlansoprazole
Pantoprazole
Sucralfate
Rabeprazole