Uterine fibroids can be treated with the same methods like sporadic uterine fibroids including antihormonal treatment, surgery or embolisation. Substantially elevated risk of progression to or independent development of uterine leiomyosarcoma has been reported which may influence treatment methods. The predisposition to renal cell cancer calls for screening and, if necessary, urological management. The skin lesions may be difficult to treat as they tend to recur after excision or destructive treatment. Drugs which affect smooth muscle contraction, such as doxazosin, nitroglycerine, nifedipine and phenoxybenzamine, may provide pain relief. Topical lidocaine patches have been reported to decrease in severity and frequency of pain cutaneous leiomyomas.
Hereditary leiomyomatosis and renal cell cancer syndrome
Menke-Hennekam syndrome
Hereditary leiomyomatosis and renal cell carcinoma
Fryns syndrome
Heerfordt syndrome
Serrated polyposis syndrome
Hereditary breast–ovarian cancer syndrome
Ehlers–Danlos syndromes