The T-Lymphocyte<unk><unk>  Profile<unk> , T4:T8<unk> , CD4:CD8<unk>  is a basic laboratory test in which the percentage of CD3-positive lymphocytes in the blood positive for CD4 (T<unk>  cells) and CD8 (a class of regulatory T cells) are counted and compared. Normal values (95% confidence intervals) are approximately 30-60% CD4 and 10-30% CD8 depending on age<unk>  0.9 to 3.7 in adults). One reason for abnormal results is the loss of CD4-positive cells to the human immunodeficiency virus (HIV) infection. The loss of CD4-positive cells to HIV infection can result in various distortions in the<unk> , as in the initial period, production of HIV specific CD8 positive cells will cause a large fall in the<unk> , but subsequent immunosuppression over time may lead to overall non production of immune cells and inversion of the<unk> . It has been shown that the degree of inversion of this<unk>  in individuals on antiretroviral therapy is indicative of the age of the infection and independently predictive of mortality associated with non HIV events.
Helper/suppressor ratio
Phenotypic response surfaces
Extraction ratio
Lineage markers
Mutational signatures
Fractional kill
Proliferative index
Lutheran antigen system