Several treatment guidelines recommend pharmaceutical treatments that include either the combination of a second-generation antidepressant and atypical antipsychotic or tricyclic antidepressant monotherapy or electroconvulsive therapy (ECT) as the first-line treatment for unipolar<unk> . There is no evidence for or against the use of mifepristone. Combined antidepressant and antipsychotic medications There is some evidence indicating that combination therapy with an antidepressant plus an antipsychotic is more effective in treating<unk>  than either antidepressant treatment alone or placebo. In the context of<unk> , the following are the most well-studied antidepressant/antipsychotic combinations: First-generation * Amitriptyline/perphenazine * Amitriptyline/haloperidol Second-generation * Venlafaxine/quetiapine * Olanzapine/fluoxetine * Olanzapine/sertraline Antidepressant medications There is insufficient evidence to determine if treatment with an antidepressant alone is effective. Tricyclic antidepressants may be particularly dangerous, because overdosing has the potential to cause fatal cardiac arrhythmias. Antipsychotic medications There is insufficient evidence to determine if treatment with antipsychotic medications alone is effective. Olanzapine may be an effective monotherapy in<unk> , although there is evidence that it is ineffective for depressive symptoms as a monotherapy; and olanzapine/fluoxetine is more effective. Quetiapine monotherapy may be particularly helpful in<unk>  since it has both antidepressant and antipsychotic effects and a reasonable tolerability profile compared to other atypical antipsychotics. The current drug-based treatments of<unk>  are reasonably effective but can cause side effects, such as nausea, headaches, dizziness, and weight gain. Electroconvulsive therapy (ECT) In modern practice of ECT a therapeutic clonic seizure is induced by electric current via electrodes placed on a person under anesthesia who is unconscious. Despite much research the exact mechanism of action of ECT is still not known. ECT carries the risk of temporary cognitive deficits (e.g., confusion, memory problems), in addition to the burden of repeated exposures to general anesthesia.
Psychotic depression
Depression 
Double depression
Collective depression
Retarded depression
Late life depression
Masked depression
Melancholic depression