<unk> , is a rare form of microlissencephaly caused by a mutation in the RELN gene. A small number of cases have been described. The syndrome was first reported by Margaret Grace<unk>  and M.<unk>  et al. in 1976. Lack of reelin prevents<unk>  layering of the cerebral cortex and disrupts cognitive development. Patients have cerebellar hypoplasia and suffer from congenital lymphedema and hypotonia. The disorder is also associated with myopia, nystagmus and generalized seizures.<unk>  is one of two known disorders caused by a disruption of the reelin-signaling pathway. The other is VLDLR-associated cerebellar hypoplasia, which is caused by a mutation in the gene coding for one of the reelin receptors, VLDLR. Disruption of the RELN gene in human patients is analogous to the malfunctioning RELN gene in the reeler mouse.
Norman–Roberts syndrome
Marden–Walker syndrome
Lethal congenital contracture syndrome
Robinow syndrome
Kandinsky–Clérambault syndrome
Dubowitz syndrome
Anton syndrome
Jordans' anomaly