<unk>  is a form of paraproteinemia and plasma cell dyscrasia that involves the proliferation of cells producing immunoglobulin<unk><unk> s. This<unk>  is characterized by an excessive production of<unk><unk> s that are short and truncated. These<unk>  proteins have various deletions, mainly in their amino-terminal part, which causes the<unk><unk> s to lose the ability to form disulfide bonds with the light<unk> s. The defect in the immunoglobulins presumably arises during somatic hypermutation. Deletion of the N-terminal part of the<unk>  protein leads to aggregation and signaling of the B cell receptor, presumably due to the loss of the anti-aggregating properties of the light<unk> .
Heavy chain disease
AL amyloidosis
Light chain deposition disease
AA amyloidosis
Monoclonal gammopathy
Familial renal amyloidosis
Monoclonal gammopathy of undetermined significance
Haemodialysis-associated amyloidosis