<unk>  has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as V(D)J recombination. This protein is also found to control the accessibility of a region of the genome that contains the T-cell receptor gamma gene, by STAT5 and histone acetylation . Knockout studies in mice suggest that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. Functional defects in this protein may be associated with the pathogenesis of severe combined immunodeficiency (SCID).
Interleukin-7 receptor
Interleukin-3 receptor
IL-2 receptor
Interferon-induced transmembrane protein 5
Type I cytokine receptor
Type II cytokine receptor
Fc receptor-like molecule
Fc receptor