H&E stain of<unk><unk>  polyp showing shortening of the gastric pits with cystic dilatation The development of polyps depends on the underlying disorder. In sporadic cases of FGPs, more than 90% of patients have activating mutations in the β-catenin gene, so that they may be considered "neoplastic" polyps. In familial adenomatous<unk> , the abnormality is a mutation in the APC gene, resulting in its inactivity. Attenuated FAP can occur from other mutations in the APC gene, and causes a phenotype wherein colonic polyps may be few in number. Both the β-catenin gene and the APC gene are involved in the same cell growth signalling pathway, but the APC gene is known to have a significantly higher association with the development of colorectal tumors.
Fundic gland polyposis
Macular corneal dystrophy
Congenital cataract
Corneal dystrophy
Ocular melanosis
Otosclerosis
Subepithelial mucinous corneal dystrophy
Vitreous bulge