left A pathological specimen showing toxic megacolon The pathological process involves inflammation and damage to the colonic wall with unknown toxins breaking down the protective mucosal barrier and exposing the muscularis propria. There is relative destruction of the ganglion cells and swelling of the nerve fibers in the myenteric plexus, with concomitant damage to the colonic musculature. This results in almost complete paralysis of the diseased segment of the colon with loss of smooth muscle substance, tone and motility. This can lead to further complications as pressure builds up in the colon due to relative fecal stasis including sepsis, intestinal hemorrhage or free perforation and spontaneous decompression.
complications of Campylobacteriosis
complications of Shigellosis
complications of Cholera
complications of Lemierre's syndrome
complications of Typhus
complications of Amoebiasis
complications of Gonorrhea
complications of Helicobacter pylori