People may be diagnosed after prolonged and/or recurring bleeding episodes. Children and adults may also be diagnosed after profuse bleeding after a trauma or tooth extraction. Ultimately, a laboratory diagnosis is usually required. This would utilize platelet aggregation studies and flow cytometry. Classification<unk> s can be further categorized: * caused by auto-immune disorders, for example Immune thrombocytopenic purpura (ITP), and characterized by low platelet count, but high MPV (mean platelet volume). * Caused by glycoprotein abnormalities: Bernard–Soulier syndrome, velocardiofacial syndrome * Caused by calpain defect: Montreal platelet syndrome * Caused by alpha granules defect: gray platelet syndrome * Characterized by abnormal neutrophil inclusions: May–Hegglin anomaly, Sebastian syndrome * With systemic manifestations: Hereditary macrothrombocytopenia with hearing loss, Epstein syndrome, Fechtner syndrome * With no specific abnormalities: Mediterranean macrothrombocytopenia * Harris platelet syndrome
Giant platelet disorder
Sticky platelet syndrome
Pseudo gray platelet syndrome
Quebec platelet disorder
Gray platelet syndrome
Factor VII deficiency
Congenital hypofibrinogenemia
Von Willebrand disease