There is reason for caution with prescribing the ingestion of high doses of<unk>  and iodate, as their unnecessary use can cause conditions such as the Jod-Basedow phenomena, trigger and/or worsen hyperthyroidism and hypothyroidism, and then cause temporary or even permanent thyroid conditions. It can also cause sialadenitis (an inflammation of the salivary gland), gastrointestinal disturbances, and rashes.<unk>  is also not recommended for people with dermatitis herpetiformis and hypocomplementemic vasculitis – conditions that are linked to a risk of<unk>  sensitivity. There have been some reports of<unk>  treatment causing swelling of the parotid gland (one of the three glands that secrete saliva), due to its stimulatory effects on saliva production. A saturated solution of<unk>  (SSKI) is typically given orally in adult doses several times a day (5 drops of SSKI assumed to be mL) for thyroid blockade (to prevent the thyroid from excreting thyroid hormone) and occasionally this dose is also used, when<unk>  is used as an expectorant (the total dose is about one gram<unk>  per day for an adult). The anti-radioiodine doses used for uptake blockade are lower, and range downward from 100 mg a day for an adult, to less than this for children (see table). All of these doses should be compared with the far lower dose of<unk>  needed in normal nutrition, which is only 150 μg per day (150 micrograms, not milligrams). At maximal doses, and sometimes at much lower doses, side effects of<unk>  used for medical reasons, in doses of 1000 times the normal nutritional need, may include: acne, loss of appetite, or upset stomach (especially during the first several days, as the body adjusts to the medication). More severe side effects that require notification of a physician are: fever, weakness, unusual tiredness, swelling in the neck or throat, mouth sores, skin rash, nausea, vomiting, stomach pains, irregular heartbeat, numbness or tingling of the hands or feet, or a metallic taste in the mouth. In the event of a radioiodine release the ingestion of prophylaxis<unk> , if available, or even iodate, would rightly take precedence over perchlorate administration, and would be the first line of defence in protecting the population from a radioiodine release. However, in the event of a radioiodine release too massive and widespread to be controlled by the limited stock of<unk>  and iodate prophylaxis drugs, then the addition of perchlorate ions to the water supply, or distribution of perchlorate tablets would serve as a cheap, efficacious, second line of defense against carcinogenic radioiodine bioaccumulation. The ingestion of goitrogen drugs is, much like<unk>  also not without its dangers, such as hypothyroidism. In all these cases however, despite the risks, the prophylaxis benefits of intervention with<unk> , iodate or perchlorate outweigh the serious cancer risk from radioiodine bioaccumulation in regions where radioiodine has sufficiently contaminated the environment.<unk>  in its raw form is a mild irritant and should be handled with gloves. Chronic overexposure can have adverse effects on the thyroid.<unk>  is a possible teratogen.
Potassium iodide
Sodium fluoride
Potassium fluoride
Lugol's iodine
Sodium benzoate
Amine fluoride
Silver diammine fluoride
Perchloryl fluoride