<unk>  is a prodrug that<unk> ibits the formation of the mycobacterial cell wall.<unk>  must be activated by KatG, a bacterial catalase-peroxidase enzyme in Mycobacterium tuberculosis. KatG catalyzes the formation of the<unk> nicotinic acyl radical, which spontaneously couples with NADH to form the nicotinoyl-NAD adduct. This complex binds tightly to the enoyl-acyl carrier protein reductase<unk> A, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This process<unk> ibits the synthesis of mycolic acids, which are required components of the mycobacterial cell wall. A range of radicals are produced by KatG activation of<unk> , including nitric oxide, which has also been shown to be important in the action of another antimycobacterial prodrug pretomanid. 500px<unk>  is bactericidal to rapidly dividing mycobacteria, but is bacteriostatic if the mycobacteria are slow-growing. It<unk> ibits the cytochrome P450 system and hence acts as a source of free radicals.<unk>  is a mild monoamine oxidase<unk> ibitor(MAO-I).
Isoniazid
Ethambutol
Pyrazinamide
Safinamide
Ipriflavone
Pingyangmycin
Oxepanoprolinamide
Miproxifene