Perinatal and infantile<unk>  are inherited as autosomal recessive traits with homozygosity or compound heterozygosity for two defective TNSALP alleles. The mode of inheritance for childhood, adult, and odonto forms of<unk>  can be either autosomal dominant or recessive. Autosomal transmission accounts for the fact that the disease affects males and females with equal frequency. Genetic counseling is complicated by the disease’s variable inheritance pattern, and by incomplete penetration of the trait.<unk>  is a rare disease that has been reported worldwide and appears to affect individuals of all ethnicities. The prevalence of severe<unk>  is estimated to be 1:100,000 in a population of largely Anglo-Saxon origin. The frequency of mild<unk>  is more challenging to assess because the symptoms may escape notice or be misdiagnosed. The highest incidence of<unk>  has been reported in the Mennonite population in Manitoba, Canada where one in every 25 individuals are considered carriers and one in every 2,500 newborns exhibits severe disease.<unk>  is considered particularly rare in people of African ancestry in the U.S.
Hypophosphatasia
Hypoprolactinemia
Hypervalinemia
Osteomalacia
Hyperphosphatasia with mental retardation syndrome
Hyperprolinemia
Methaemalbuminaemia
Hypophosphatemia