<unk>  is a cyclosporin A analog, similar to cyclosporin A with modifications on an amino acid within one region that allows the drug to bind to Calcineurin.<unk>  inhibits calcineurin, which then blocks the production of IL-2 and T-cell mediated immune responses. As a result of the calcineurin inhibition, podocytes (cells within the kidneys) are stabilized while inflammation is reduced. Reduction of inflammation within the kidneys prevents further renal damage.
Voclosporin
Dapsone
Ciclosporin
Caspofungin
Cortistatin 
Ketoconazole
Miconazole
Itraconazole