Chloramphenicol therapy should be stopped immediately if objective or subjective signs of<unk>  are suspected since<unk>  can be fatal for the infant if it is not diagnosed early on as it can lead to anemia, shock, and end-organ damage. After discontinuing the antibiotic, the side effects caused by the toxicity should be treated. This includes treating hypoglycemia to help prevent hemodynamic instability, as well as increasing the temperature of the infant if they have developed hypothermia. Since symptoms of<unk>  are correlated with elevated serum chloramphenicol concentrations, exchange transfusion may be required to remove the drug, charcoal column hemoperfusion is a type of transfusion that has shown significant effects but is associated with numerous side effects. The associated side effects isn't the only reason why this method of treatment is not a first line therapy. According to the American Journal of Kidney Disease, elevated cartridge prices and viable lifespan of the product are deterring factors to consider. Phenobarbital and theophylline are two drugs in particular that have shown significant efficacy with charcoal hemoperfusion, aside from its most significant indication for chronic aluminum toxicity in people with end-stage renal disease (ESRD) traditionally. Sometimes, phenobarbital is used to induce UDP-glucuronyl transferase enzyme function. For hemodynamically unstable neonates, supportive care measures such as resuscitation, oxygenation, and treatment for hypothermia are common practices when cessation of chloramphenicol alone is insufficient. With sepsis being a complication of severe<unk> , usage of broad-spectrum antibiotics such as vancomycin, for example, is a recommended treatment option. Third generation antibiotics have also proven efficacy in treating<unk>  baby-induced sepsis.
Gray baby syndrome
Blue baby syndrome
Michelin tire baby syndrome
Shaken baby syndrome
Neonatal diabetes
Baboon syndrome
Hydrolethalus syndrome
Hemolytic disease of the newborn 