Mechanism of action +Binding profile Site Ki (nM) SERT 0.8-1.1 NET 7,800 DAT 27,400 5-HT1A >1,000 5-HT2A >1,000 5-HT2C 2,500 α1 3,900 α2 >1,000 D2 >1,000 H1 2,000 mACh 1,240 hERG 2,600 (IC50)<unk>  increases intrasynaptic levels of the neurotransmitter serotonin by blocking the reuptake of the neurotransmitter into the presynaptic neuron. Of the SSRIs currently available,<unk>  has the highest selectivity for the serotonin transporter (SERT) compared to the norepinephrine transporter (NET), making the side-effect profile relatively mild in comparison to less-selective SSRIs.<unk>  is a substrate of P-glycoprotein and hence P-glycoprotein inhibitors such as verapamil and quinidine may improve its blood brain barrier penetrability. In a preclinical study in rats combining<unk>  with a P-glycoprotein inhibitor, its antidepressant-like effects were enhanced.
Escitalopram
Citalopram
Atomoxetine
Sertraline
Bupropion
Dapoxetine
Fluoxetine
Duloxetine