<unk>  refers to immune system<unk>  of genetically encoded polymorphisms among the genetically distinguishable members of same species (self-non-self discrimination). Post-transplant<unk>  of<unk> s occurs in secondary lymphoid organs. Donor specific antigens are recognized by recipient’s T lymphocytes and triggers adaptive pro-inflammatory response which consequently leads to rejection of allogenic transplants. Allospecific T lymphocytes may be stimulated by three major pathways: direct<unk> , indirect<unk>  or semidirect<unk> . The pathway involved in specific cases is dictated by intrinsic and extrinsic factors of allograft and directly influence nature and magnitude of T lymphocytes mediated immune response. Furthermore, variant tissues and organs such as skin or cornea or solid organ transplants can be recognized in different pathways and therefore are rejected in different fashion. __TOC__
Alloantigen recognition
Antigen presentation
Fragment antigen-binding
Immunoglobulin class switching
Oocyte selection
Antibody opsonization
Receptor editing
Drug recycling