<unk>  <unk>  is a brain<unk>  in which scattered lesions occur over a widespread area in white matter tracts as well as grey matter.<unk>  is one of the most common and devastating types of traumatic brain<unk>  and is a major cause of unconsciousness and persistent vegetative state after severe head trauma. It occurs in about half of all cases of severe head trauma and may be the primary damage that occurs in concussion. The outcome is frequently coma, with over 90% of patients with severe<unk>  never regaining consciousness. Those who do wake up often remain significantly impaired.<unk>  can occur across the spectrum of traumatic brain<unk>  (TBI) severity, wherein the burden of<unk>  increases from mild to severe. Concussion may be a milder type of<unk> .
Diffuse axonal injury
Wallerian degeneration
Central chromatolysis
Synaptopathy
Hemorrhagic infarct
Acute motor axonal neuropathy
Posterior circulation infarct
Subacute combined degeneration of spinal cord