Patients with<unk> es are diagnosed through a physical evaluation that looks for muscle atrophy, weakness, and sensory responses. In addition to this, electromyography and<unk>  nerve conduction tests can help clinicians decide what type of<unk>  and sensory<unk>  it is and how severe the disease is. Final confirmation can come through genetic testing. Classification Charcot–Marie–Tooth disease was first described in 1886 by Jean-Martin Charcot, Pierre Marie, and independently Howard Henry Tooth. In the 1950s, further classification occurred and separated patients into two distinct groups. Group one was characterized by slow nerve conduction velocities and demyelinating<unk> . Group two was characterized by mostly normal nerve conduction velocities and degeneration of axons. In 1968,<unk>  were classified again into seven groups: + Type Other names Diseases Database OMIM<unk> 1 Charcot–Marie–Tooth disease type 1A and 1B (multiple) Hypertrophic demyelinating type: affected individuals experience weakness and atrophy in the lower legs in adolescence, and later develop weakness in the hands. This is the most common type of CMT.<unk> 2 Charcot–Marie–Tooth disease type 2 (multiple) Neuronal type: symptoms similar to type1, onset in adolescence.<unk> 3 Dejerine–Sottas disease (Charcot–Marie–Tooth type 3) Onset in infancy and results in delayed<unk>  skills, much more severe than types 1 & 2.<unk> 4 Refsum disease Spinal type: Muscle weakness and atrophy as in other types of CMT, but set apart by being autosomal recessive inheritance.<unk> 5 Charcot–Marie–Tooth with pyramidal features — Pyramidal type: onset between ages 5–12. Lower legs are affected first by muscle weakness and atrophy followed by the upper extremities. Type 5 is also associated with visual and hearing loss.<unk> 6 Charcot–Marie–Tooth type 6 Early onset muscular weakness and atrophy followed by optic atrophy resulting in vision loss and possibly blindness.<unk> 7<unk> +retinitis pigmentosa — Later onset with muscular weakness and atrophy mostly in the lower extremities.
Hereditary motor and sensory neuropathy
Hereditary sensory and autonomic neuropathy
Chronic inflammatory demyelinating polyneuropathy
Tropical neuropathy
Diabetic neuropathy
Peripheral mononeuropathy
Critical illness polyneuropathy
Vasculitic neuropathy