<unk> r stroma and extracellular matrix in<unk> <unk>  is the situation where<unk>  cells have been deprived of oxygen. As a<unk>  grows, it rapidly outgrows its blood supply, leaving portions of the<unk>  with regions where the oxygen concentration is significantly lower than in healthy tissues.<unk>  microenvironements in solid<unk> s are a result of available oxygen being consumed within 70 to 150 μm of<unk> r vasculature by rapidly proliferating<unk>  cells thus limiting the amount of oxygen available to diffuse further into the<unk>  tissue. In order to support continuous growth and proliferation in challenging<unk>  environments, cancer cells are found to alter their metabolism. Furthermore,<unk>  is known to change cell behavior and is associated with extracellular matrix remodeling and increased migratory and metastatic behavior.
Tumor hypoxia
Hypoxia 
Bone decalcification
Tumor progression
Primary tumor
Angiopathy
Neovascularization
Tissue stress