<unk>  is pregnancy category X, or "contraindicated in pregnancy", in the , and pregnancy category D, the second most restricted rating, in Australia. As such, it is contraindicated in women during pregnancy, and women who are sexually active and who can or may become pregnant are strongly recommended to take<unk>  only in combination with adequate contraception. It is unknown whether<unk>  is excreted in breast milk, but many drugs are excreted in breast milk, and for this reason,<unk>  treatment is similarly not recommended while breastfeeding. In individuals with severe, though not mild-to-moderate hepatic impairment, there is evidence that the elimination of<unk>  is slowed, and hence, caution may be warranted in these patients as circulating levels of<unk>  may be increased. In severe hepatic impairment, the elimination half-life of the active (R)-enantiomer of<unk>  is increased by about 1.75-fold (76% increase; elimination half-life of 5.9 and 10.4 days for normal and impaired patients, respectively). The elimination half-life of<unk>  is unchanged in renal impairment.
Bicalutamide
Darolutamide
Topilutamide
Apalutamide
Nilutamide
Acetothiolutamide
Flutamide
Enzalutamide