<unk>  blocks the proton pump for ATP synthase of mycobacteria. It is the first member of a new class of drugs called the diarylquinolines.<unk>  is bactericidal. ATP production is required for cellular energy production and its loss leads inhibition of mycobacterial growth within hours of the addition of<unk> . The onset of<unk> -induced mycobacterial cell death does not occur until several days after treatment, but nonetheless kills consistently thereafter. Resistance The specific part of ATP synthase affected by<unk>  is subunit c which is encoded by the gene atpE. Mutations in atpE can lead to resistance. Mutations in drug efflux pumps have also been linked to resistance. Ongoing research In vitro experiments have indicated that<unk>  may also target the mitochondrial ATP synthase of malignant mammalian cells and reduce the rate of metastasis.
Bedaquiline
Selegiline
Rasagiline
Perhexiline
Tetrabenazine
Deutetrabenazine
Butriptyline
3-Quinuclidinyl benzilate