<unk> es and other nuclear envelopathies have a large variety of clinical symptoms including skeletal and/or cardiac muscular dystrophy, lipodystrophy and diabetes, dysplasia, dermo- or neuropathy, leukodystrophy, and progeria (premature aging). Most of these symptoms develop after birth, typically during childhood or adolescence. Some<unk> es however may lead to an early death, and mutations of lamin B1 (LMNB1 gene) may be lethal before or at birth.
Laminopathy
Myopathy
Myelopathy
Osteopathy
Osteodystrophy
Arthropathy
Lipotoxicity
Osteopenia