There is a very high risk of life-threatening infections and death at an early age. The quality of life and survival greatly improves with G-CSF treatment, which is practiced since the late 1980s. Unlike severe congenital<unk> , individuals with<unk>  have a better response to G-CSF and do not have a risk of developing myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). However, in long-term observation of over 300 patients with CyN, there has been one case of developing chronic myelogenous leukemia (CML) and one of AML, indicating it is also a pre-leukemic condition, but the risk is "very low" (1%), and the risk is "correlated with disease severity rather than with occurrence of an ELANE mutation". According to Donadieu et al. (2011), "the cumulative risk of experiencing at least one serious (potentially life-threatening) infection by age 20 years is similar in patients with permanent and<unk> , although the former patients tend to have earlier manifestations".
Cyclic neutropenia
Febrile neutropenia
Agranulocytosis
Cytopenia
Autoimmune neutropenia
Lymphocytopenia
Leukopenia
Dyserythropoiesis