<unk>  (HSAN I) or hereditary sensory neuropathy type I (HSN I) is a group of autosomal dominant inherited neurological diseases that affect the peripheral nervous system particularly on the sensory and<unk>  functions. The hallmark of the disease is the marked loss of pain and temperature sensation in the distal parts of the lower limbs. The<unk>  disturbances, if present, manifest as sweating abnormalities. The beginning of the disease varies between adolescence and adulthood. Since affected individuals cannot feel pain, minor wounds or blisters in the painless area may not be immediately recognized and can develop into extensive and deep foot ulcerations. Once infection occurs, the complications such as inflammation and progressive destruction of the underlying bones may follow and may require amputation of the surrounding area. HSAN I is the most common type among the five types of HSAN. As a heterogeneous group of diseases, HSAN I can be divided into five subtypes HSAN IA-E. Most of the genes associated with the diseases have been identified. However, the molecular pathways leading to the manifestation of the diseases are not fully understood. Therefore, the potential targets for therapeutic interventions are not known. Moreover, gene-based therapies for patients with the diseases are not available to date, hence supportive care is the only treatment available for the patients.
Hereditary sensory and autonomic neuropathy type I
Distal hereditary motor neuropathy type V
Familial amyloid neuropathy
Congenital myasthenic syndrome
Familial amyloid polyneuropathy
Hereditary motor and sensory neuropathy
Lambert–Eaton myasthenic syndrome
MGUS polyneuropathy