<unk>  The major symptoms of<unk>  include scaling of the skin, particularly on the neck, trunk, and lower extremities. The extensor surfaces are typically the most severely affected areas. The >4 mm diameter scales adhere to the underlying skin and can be dark brown or gray in color. Symptoms may subside during the summer. Associated medical conditions Aside from the skin scaling,<unk>  is not typically associated with other major medical problems. Atrial fibrillation or atrial flutter may affect up to 1 in 10 males with<unk>  Corneal opacities may be present but do not affect vision. Cryptorchidism is reported in some individuals. Individuals affected by<unk>  may be affected by bleeding problems and Dupuytren's contracture more often than unaffected individuals, although these medical conditions are rare. Individuals with<unk>  appear at increased risk of developmental disorders such as autism and Attention Deficit Hyperactivity Disorder and some affected individuals exhibit mood problems Mood problems in<unk>  appear to be most influenced by stigma or bullying associated with the skin condition, and by difficulties with treating the skin condition. Individuals with<unk>  can exhibit intellectual disability, although this is thought to be due to deletions encompassing neighboring genes in addition to STS. Female carriers generally do not experience any of these problems but can have difficulty during childbirth, as the STS expressed in the placenta plays a role in normal labor. Female carriers may also be at slightly increased risk of developing mental health problems following childbirth For these reasons carriers should ensure their obstetrician is aware of the condition.
X-linked ichthyosis
Keratoderma
Poikiloderma
Dyskeratosis congenita
Halogenoderma
Photodermatosis
Chyloderma
Bromoderma