Patients with<unk>  typically have moderate to severe intellectual disability. Speech is delayed and once acquired is limited to single words. Behavioral problems such as hyperactivity, aggression and autistic features can occur. As of 2017 three patients with<unk>  have been reported, all of whom have been dependent on assistance in all aspects of daily living. Hypotonia occurs in infancy and in most cases later progresses to mild spasticity in all four limbs. Walking is delayed and in all cases is unsteady. Joint hyperlaxity may occur.
Alwadei syndrome
MELAS syndrome
Schwartz–Matsuo syndrome
Witteveen–Kolk syndrome
RAPADILINO syndrome
Pashayan syndrome
HAIR-AN syndrome
STAR syndrome