UCD commonly presents without symptoms; however, people with the disease may experience enlarged lymph nodes in a single lymph node region or report symptoms related to compression of neighboring structures by enlarged lymph nodes, such as difficulty breathing and pain or pressure in the abdomen or chest. Systemic symptoms (fever, night sweats, weight loss, fatigue), extravascular fluid accumulation (peripheral edema, ascites, pleural effusions), and enlargement of the liver and/or spleen, all of which are commonly seen in HHV-8-associated MCD and iMCD, are uncommon in UCD. Associated diseases UCD is associated with increased risk of paraneoplastic pemphigus.
Unicentric Castleman disease
Idiopathic multicentric Castleman disease
Follicular lymphoma
Follicular dendritic cell sarcoma
Progressive nodular histiocytoma
Thymic carcinoma
Marginal zone B-cell lymphoma
Progressive nodular histiocytosis