There is a defect in DNA synthesis in the rapidly dividing cells and to a lesser extent, RNA and protein synthesis are also impaired. Therefore, unbalanced cell proliferation and impaired cell division occur as a result of arrested nuclear maturation so the cells show nuclear-cytoplasmic asynchrony. In the bone marrow, most megaloblasts are destroyed prior to entering the peripheral blood (intramedullary hemolysis). Some can escape the bone marrow (macrocytes) to peripheral blood but they are destroyed by the reticulo-endothelial system (extramedullary hemolysis).
complications of Lesch–Nyhan syndrome
complications of Myotonic dystrophy
complications of Botulism
complications of Kallmann syndrome
symptom of Lesch–Nyhan syndrome
complications of Hashimoto's thyroiditis
complications of Fabry disease
symptom of Maroteaux–Lamy syndrome