<unk>  is a genus of viruses in the order Picornavirales, in the family Picornaviridae. Pig and maybe also cow serve as natural hosts. There is only one species in this genus:<unk>  A.<unk>  is a replication-competent oncolytic picornavirus. It has selective tropism for cancers with neuroendocrine features including small cell lung cancer (SCLC) and several pediatric solid tumors including retinoblastoma, neuroblastoma, and medulloblastoma. A Phase I clinical trial of<unk>  in adults with neuroendocrine tumors showed that<unk>  is apparently safe to administer at doses up to 1E11 vp/kg. It has potential antineoplastic activity.
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