<unk> , sold under the brand names Wellbutrin and Zyban among others, is an atypical antidepressant primarily used to treat major depressive disorder and to support smoking cessation.<unk>  is an effective antidepressant on its own, but it is also popular as an add-on medication in the cases of incomplete response to the first-line selective serotonin reuptake inhibitor (SSRI) antidepressant.<unk>  has several features that distinguish it from other antidepressants: it does not usually cause sexual dysfunction; it is not associated with weight gain and sleepiness, and it is more effective than SSRIs at improving symptoms of hypersomnia and fatigue.<unk>  does, however, carry a much higher risk of seizure than many other antidepressants and extreme caution must be taken in patients with a history of seizure disorder. Common adverse effects of<unk>  with the greatest difference from placebo are dry mouth, nausea, constipation, insomnia, anxiety, tremor, and excessive sweating. Raised blood pressure is notable. Rare but serious side effects include seizure, liver toxicity, psychosis, and risk of overdose.<unk>  use during pregnancy may be associated with increased odds of congenital heart defects.<unk>  acts as a norepinephrine–dopamine reuptake inhibitor and a nicotinic receptor antagonist. Chemically, it is an aminoketone that belongs to the class of substituted cathinones and more generally that of substituted amphetamines and substituted phenethylamines.<unk>  was invented by Nariman Mehta, who worked at Burroughs Wellcome, in 1969. It was first approved for medical use in the United States in 1985.<unk>  was originally called by the generic name amfebutamone, before being renamed in 2000. In 2019, it was the 22nd most commonly prescribed medication in the United States, with more than 25million prescriptions. It is on the World Health Organization's List of Essential Medicines.
Bupropion
Atomoxetine
Hydroxybupropion
Entropion
Citalopram
Duloxetine
Dapoxetine
Fluoxetine