A<unk>  is a pharmaceutical drug that suppresses the physiologic response to tumor necrosis factor <unk> , which is part of the inflammatory response.<unk>  is involved in autoimmune and immune-mediated disorders such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, psoriasis, hidradenitis suppurativa and refractory asthma, so<unk> s may be used in their treatment. The important side effects of<unk> s include lymphomas, infections (especially reactivation of latent tuberculosis), congestive heart failure, demyelinating disease, a lupus-like syndrome, induction of auto-antibodies, injection site reactions, and systemic side effects. The global market for<unk> s in 2008 was $13.5 billion and $22 billion in 2009.
TNF inhibitor
CXCR4 antagonist
Tissue factor pathway inhibitor
COX-2 inhibitor
CDK inhibitor
Anticorticosteroid
Growth factor receptor inhibitor
RET inhibitor