This chemogenetic technique can be used for remote manipulation of cells, in particular excitable cells like neurons, both in vitro and in vivo with the administration of specific<unk> s. Similar techniques in this field include thermogenetics and optogenetics, the control of neurons with temperature or light, respectively. Viral expression of DREADD proteins, both in-vivo enhancers and inhibitors of neuronal function, have been used to bidirectionally control behaviors in mice (e.g odor discrimination). Due to their ability to modulate neuronal activity, DREADDs are used as a tool to evaluate both the neuronal pathways and behaviors associated with drug-cues and drug addiction.
Receptor activated solely by a synthetic ligand
GABAA receptor negative allosteric modulator
Protein kinase inhibitor
Cysteine-rich secretory protein
TP53-inducible glycolysis and apoptosis regulator
GABAA receptor positive allosteric modulator
Tumor M2-PK
CCR5 receptor antagonist