<unk> s available for use as therapeutic agents are produced by recombinant DNA technology in cell culture, and include<unk> ogen/Procrit <unk> oetin alfa) and Aranesp (darbepoetin alfa); they are used in treating anemia resulting from chronic kidney disease, chemotherapy induced anemia in patients with cancer, inflammatory bowel disease (Crohn's disease and ulcerative colitis) and myelodysplasia from the treatment of cancer (chemotherapy and radiation). The package inserts include boxed warnings of increased risk of death, myocardial infarction, stroke, venous thromboembolism, and tumor recurrence, particularly when used to increase the hemoglobin levels to more than 11 g/dL to 12 g/dL.
Erythropoietin
Granulocyte colony-stimulating factor
Thyroglobulin
Granulocyte-macrophage colony-stimulating factor
Hemopoietic growth factor
Growth hormone
Parathyroid hormone
Colony-stimulating factor