Symptoms vary widely between sources of<unk> ity, dosage, length of time patient was exposed to the<unk>  substance, patient history, and patient genetics. Especially in the case of leukoencephalopathy developing due to substance use or environmental<unk> s, symptoms typically do not develop until several days to months after exposure to the pharmacological agent. Clinical features range from inattention, forgetfulness, and changes in personality to dementia, coma, and even death. Obvious signs of the condition are difficulty with cognitive function and equilibrioception. Common initial symptoms include confusion, somnolence, generalized seizures, headaches, and vision impairment. Young acute lymphoblastic leukemia patients with methotrexate-induced leukoencephalopathy appear asymptomatic. However,<unk>  induced by substance use or environmental<unk> s have had more damaging side effects. Heroin-induced leukoencephalopathy has had three stages described. The first stage features soft (pseudobulbar) speech, cerebellar ataxia, motor restlessness, and apathy/bradyphrenia. The intermediate stage includes pyramidal tract and pseudobulbar signs, spastic paresis, myoclonic jerks, and choreoathetoid movements. The final or terminal stage is characterized by stretching spasms, akinetic mutism, hypotonic paresis, central pyrexia, and death. Similarly, leukoencephalopathy induced by orally administered methotrexate for arthritis patients presents similar symptoms including ataxia, dysarthria, and seizures; however, long-term cognitive effects remain unknown. Symptoms of leukoencephalopathy caused by overdose of metronidazole medication include dysarthria, gait disturbance, weakness of extremities, and mental confusion. Despite the pharmacological agent or source of<unk> ity, some patients completely recover from<unk> . Related disorders Posterior reversible encephalopathy syndrome (PRES) can also result from medication<unk> ity. Symptoms similar to those of leukoencephalopathy patients have been seen in PRES patients. However, the prognosis of<unk>  is typically slightly worse than that of PRES because<unk>  is more likely to lead to ataxia, dementia, or coma. Hypoglycemic encephalopathy is often seen in diabetics as a result to accidental overdose with the long-acting sulfonylurea drug group. Brain regions affected by<unk>  have been seen to be affected by this disease as well; however, hypoglycaemic encephalopathy has been known to involve both white and grey matter abnormalities.
Toxic leukoencephalopathy
Powassan encephalitis
Progressive multifocal leukoencephalopathy
Viral encephalitis
Herpesviral encephalitis
Autoimmune encephalitis
Tuberculous meningitis
Polioencephalitis