There are no specific tests for<unk> , but non-specific laboratory tests are used to rule out other causes such as vitamin deficiencies. Five symptoms are used to confirm the diagnosis: * A strong urge to move the limbs, usually associated with unpleasant or uncomfortable sensations. * It starts or worsens during inactivity or rest. * It improves or disappears (at least temporarily) with activity. * It worsens in the evening or night. * These symptoms are not caused by any medical or behavioral condition. These symptoms are not essential, like the ones above, but occur commonly in<unk>  patients: * genetic component or family history with<unk>  * good response to dopaminergic therapy * periodic leg movements during day or sleep * most strongly affected are people who are middle-aged or older * other sleep disturbances are experienced * decreased iron stores can be a risk factor and should be assessed According to the International Classification of Sleep Disorders (ICSD-3), the main symptoms have to be associated with a sleep disturbance or impairment in order to support<unk>  diagnosis. As stated by this classification,<unk>  symptoms should begin or worsen when being inactive, be relieved when moving, should happen exclusively or mostly in the evening and at night, not be triggered by other medical or behavioral conditions, and should impair one's quality of life. Generally, both<unk>  are affected, but in some cases there is an asymmetry. Differential diagnosis The most common conditions that should be differentiated with<unk>  include leg cramps, positional discomfort, local leg injury, arthritis, leg edema, venous stasis, peripheral neuropathy, radiculopathy, habitual foot tapping/leg rocking, anxiety, myalgia, and drug-induced akathisia. Peripheral artery disease and arthritis can also cause leg pain but this usually gets worse with movement. There are less common differential diagnostic conditions included myelopathy, myopathy, vascular or neurogenic claudication, hypotensive akathisia, orthostatic tremor, painful<unk> , and moving toes.
Restless legs syndrome
Akathisia
Parkinsonism
Insomnia
Cancer-related fatigue
Gigantism
Bruxism
Lonomia