Family and homology<unk>  belongs to the α-KTx family. This peptide has not shown a high percentage of sequence similarity with other toxins selective for the same family of K+ channels α-KTx and may be classified in a new group among the related Kv blocker. Structure<unk>  complete sequence has a mass of 6,763 kDa and is constituted by 60 amino acids. The mature toxin, which misses the signal peptide of 22 amino acids, has a mass of 4,33 kDa and is constituted by 38 amino acids residues. The peptide folds in three secondary structures: one α-helix at N-terminus, three anti-parallel β-sheets at C-terminus. The α-helix contains acidic residues, whereas β-sheets contain basic ones. Additionally, three disulphide bridges form the tertiary structure. These structures patterns suggest that<unk>  may be a potential Kv channel blocker for its similarity with Kv channel blocker family. Although, its amino acid sequence is not very similar, the predicted folded protein was reasonably similar to most Kv channel blockers. The typical aromatic ring with a lysine, found for alpha-KTX-family is present. Amino acid sequence: MSNFSVFLIA LLFCSVFILS EAQIYTSKEC NGSSECYSHC EGITGKRSGK CINKKCYCYR
ImKTx88
AVN-211
CISEPO
SimThyr
D-DIA
Co-codaprin
Adamantyl-THPINACA
TYROBP