Death toll Beyond the estimations done by Motolinia and others for New Spain, most of the death toll figures cited for the outbreak of 1545–1548 are concerned with Aztec populations. Around 800,000 died in the Valley of Mexico, which led to the widespread abandonment of many indigenous sites in the area during, or, shortly after this four-year period. Estimates for the entire number of human lives lost during this<unk> have ranged from 5 to 15 million people, making it one of the most deadly disease outbreaks of all time. Other The effects of the outbreak extended beyond just a loss in terms of population. The lack of indigenous labor led to a sizeable food shortage, which affected both the natives and Spanish. The death of many Aztecs due to the plague led to a void in land ownership, with Spanish colonists of all backgrounds looking to exploit these now vacant lands. Coincidentally, the Spanish Emperor, Charles V, had been seeking a way to disempower the encomendero class, and establish a more efficient and "ethical" settlement system. Starting around the end of the outbreak in 1549, the encomederos, crippled by the loss in profits resulting and unable to meet the demands of New Spain, were forced to comply with the new tasaciones (regulations). The new ordinances, known as Leyes Nuevas aimed to limit the amount of tribute encomenderos could personally extract, while also prohibiting them from exercising absolute control over the labor force. Simultaneously, non-encomenderos began claiming lands lost by the encomenderos, as well as, the labor provided by the indigenous. This developed in to the implementation of the repartimiento system, which sought to institute a higher level of oversight within the Spanish colonies and maximize the overall tribute extracted for public and crown use. Rules regarding tribute itself were also changed in response to the<unk> of 1545, as fears over future food shortages ran rampant among the Spanish. By 1577, after years of debate and a second major outbreak of<unk> , maize and money were designated as the only two forms of acceptable tribute.
Cocoliztli epidemics
Tanganyika laughter epidemic
Native American disease and epidemics
Virgin soil epidemic
Death rattle
symptoms of Yellow fever
Asclepiades of Bithynia
Flavescence dorée