Although it is only partly understood, pathophysiology of<unk>  may involve dopamine and iron system anomalies. There is also a commonly acknowledged circadian rhythm explanatory mechanism associated with it, clinically shown simply by biomarkers of circadian rhythm, such as body temperature. The interactions between impaired neuronal iron uptake and the functions of the neuromelanin-containing and dopamine-producing cells have roles in<unk>  development, indicating that iron deficiency might affect the brain dopaminergic transmissions in different ways. Medial thalamic nuclei may also have a role in<unk>  as part as the limbic system modulated by the dopaminergic system which may affect pain perception. Improvement of<unk>  symptoms occurs in people receiving low-dose dopamine agonists.
Restless legs syndrome
Akathisia
Parkinsonism
Insomnia
Cancer-related fatigue
Gigantism
Bruxism
Lonomia