<unk>  is a 10-23 DNAzyme that targets c-Jun, a transcription factor found in diseased blood vessels, eyes, lungs and joints. The treatment works by the DNA-based enzyme binding to and catalytically destroying its target messenger RNA, thereby inhibiting c-Jun expression in cells.<unk>  has underpinned the development of a library of programmable DNAzymes operable in a cellular environment. The potential of<unk>  as a therapeutic agent derives from the fact that inactivation of c-Jun can have an effect on downstream genes such as MMP-2, MMP-9, VEGF and FGF-2.<unk>  also inhibits the expression of pro-inflammatory cytokines such as TNF-alpha, interferon gamma and IL-6.<unk>  has been used with carriers such as cationic polymers for improved cellular delivery and efficacy.<unk>  in such polymers inhibits tumor cell proliferation and migration by suppressing levels of c-Jun and MMPs, reduces H1N1 and H7N2 viral replication and increases survival of mice infected with influenza A and suppresses c-Jun and solid tumor growth in biomimetic nanoballs.<unk>  has also been used in dermal drug delivery systems for enhanced skin penetration of DNAzyme. It has been reported off-target effects of<unk> , not related to the inactivation of c-Jun
Dz13
Lq2
COVAX-19
ZF2001
P14arf
AP-7 
YK-11
Ty21a