Most people with<unk>  experience nothing more than mild skin lesions that can be treated effectively with topical therapies.<unk>  is known to hurt the quality of life of both the affected person and the individual's family members. Depending on the severity and location of outbreaks, individuals may experience significant physical discomfort and some disability. Itching and pain can interfere with basic functions, such as self-care and sleep. Participation in sporting activities, certain occupations, and caring for family members can become difficult activities for those with plaques located on their hands and feet. Plaques on the scalp can be particularly embarrassing, as flaky plaque in the hair can be mistaken for dandruff. Individuals with<unk>  may feel self-conscious about their appearance and have a poor self-image that stems from fear of public rejection and psychosexual concerns.<unk>  has been associated with low self-esteem and depression is more common among those with the condition. People with<unk>  often feel prejudiced against due to the commonly held incorrect belief that<unk>  is contagious. Psychological distress can lead to significant depression and social isolation; a high rate of thoughts about suicide has been associated with<unk> . Many tools exist to measure the quality of life of people with<unk>  and other dermatological disorders. Clinical research has indicated individuals often experience a diminished quality of life. Children with<unk>  may encounter bullying. Several conditions are associated with<unk> . These occur more frequently in older people. Nearly half of individuals with<unk>  over the age of 65 have at least three comorbidities (concurrent conditions), and two-thirds have at least two comorbidities. Cardiovascular disease<unk>  has been associated with obesity and several other cardiovascular and metabolic disturbances. The number of new cases per year of diabetes is 27% higher in people affected by<unk>  than in those without the condition. Severe<unk>  may be even more strongly associated with the development of diabetes than mild<unk> . Younger people with<unk>  may also be at increased risk for developing diabetes. Individuals with<unk>  or psoriatic arthritis have a slightly higher risk of heart disease and heart attacks when compared to the general population. Cardiovascular disease risk appeared to be correlated with the severity of<unk>  and its duration. There is no strong evidence to suggest that<unk>  is associated with an increased risk of death from cardiovascular events. Methotrexate may provide a degree of protection for the heart. The odds of having hypertension are 1.58 times higher in people with<unk>  than those without the condition; these odds are even higher with severe cases of<unk> . A similar association was noted in people who have psoriatic arthritis—the odds of having hypertension were found to be 2.07 times greater when compared to odds of the general population. The link between<unk>  and hypertension is not currently understood. Mechanisms hypothesized to be involved in this relationship include the following: dysregulation of the renin–angiotensin system, elevated levels of endothelin 1 in the blood, and increased oxidative stress. The number of new cases of the heart rhythm abnormality atrial fibrillation is 1.31 times higher in people with mild<unk>  and 1.63 times higher in people with severe<unk> . There may be a slightly increased risk of stroke associated with<unk> , especially in severe cases. Treating high levels of cholesterol with statins has been associated with decreased<unk>  severity, as measured by PASI score, and has also been associated with improvements in other cardiovascular disease risk factors such as markers of inflammation. These cardioprotective effects are attributed to ability of statins to improve blood lipid profile and because of their anti-inflammatory effects. Statin use in those with<unk>  and hyperlipidemia was associated with decreased levels of high-sensitivity C-reactive protein and TNFα as well as decreased activity of the immune protein LFA-1. Compared to individuals without<unk> , those affected by<unk>  are more likely to satisfy the criteria for metabolic syndrome. Other diseases The rates of Crohn disease and ulcerative colitis are increased when compared with the general population, by a factor of 3.8 and 7.5 respectively. People with<unk>  also have a higher risk of celiac disease. Few studies have evaluated the association of multiple sclerosis with<unk> , and the relationship has been questioned.<unk>  has been associated with a 16% increase in overall relative risk for non-skin cancer, thought to be attributed to systemic therapy, particularly methotrexate. People treated with long term systemic therapy for<unk>  have a 52% increased risk cancers of the lung and bronchus, a 205% increase in the risk of developing cancers of the upper gastrointestinal tract, a 31% increase in the risk of developing cancers of the urinary tract, a 90% increase in the risk of developing liver cancer, and a 46% increase in the risk of developing pancreatic cancer. The risk for development of non-melanoma skin cancers is also increased.<unk>  increases the risk of developing squamous cell carcinoma of the skin by 431% and increases the risk of basal cell carcinoma by 100%. There is no increased risk of melanoma associated with<unk> . People with<unk>  have a higher risk of developing cancer.
Psoriasis
Onychomycosis
Parapsoriasis
Basal-cell carcinoma
Lupus vulgaris
Dermatitis
Vitiligo
Dandruff