Skin, vaginal, mouth, and esophageal Candida infections usually respond well to treatment with<unk> . Infections of nails or hyperkeratinized skin do not respond well. It is available in many forms. When given parenterally, its activity is reduced due to presence of plasma. Oral<unk>  is often used as a preventive treatment in people who are at risk for fungal infections, such as AIDS patients with a low CD4+ count and people receiving chemotherapy. It has been investigated for use in patients after liver transplantation, but fluconazole was found to be much more effective for preventing colonization, invasive infection, and death. It is effective in treating oral candidiasis in elderly people who wear dentures. It is also used in very low birth-weight (less than 1500 g or 3 lb 5oz o) infants to prevent invasive fungal infections, although fluconazole is the preferred treatment. It has been found to reduce the rate of invasive fungal infections and also reduce deaths when used in these babies. Liposomal<unk>  is not commercially available, but investigational use has shown greater in vitro activity than colloidal formulations of amphotericin B, and demonstrated effectiveness against some amphotericin B-resistant forms of fungi. It offers an intriguing possibility for difficult-to-treat systemic infections, such as invasive aspergillosis, or infections that demonstrate resistance to amphotericin B. Cryptococcus is also sensitive to<unk> . Additionally, liposomal<unk>  appears to cause fewer cases of and less severe nephrotoxicity than observed with amphotericin B. In the UK, its license for treating neonatal oral thrush is restricted to those over the age of one month. It is prescribed in 'units', with doses varying from 100,000 units (for oral infections) to 1 million (for intestinal ones). As it is not absorbed from the gut, it is fairly safe for oral use and does not have problems of drug interactions. On occasion, serum levels of the drug can be identified from oral, vaginal, or cutaneous administration, and lead to toxicity.
Nystatin
Terbinafine
Itraconazole
Sertaconazole
Ketoconazole
Posaconazole
Urodilatin
Miconazole