Typical saddle nose damage due to<unk> . Initial signs are highly variable, and diagnosis can be severely delayed due to the nonspecific nature of the symptoms. In general, irritation and inflammation of the nose is the first sign in most people. Involvement of the upper respiratory tract, such as the nose and sinuses, is seen in nearly all people with<unk> . Typical signs and symptoms of nose or sinus involvement include crusting around the nose, stuffiness, nosebleeds, runny nose, and saddle-nose deformity due to a hole in the septum of the nose. Inflammation of the outer layers of the eye (scleritis and episcleritis) and conjunctivitis are the most common signs of<unk>  in the eye; involvement of the eyes is common and occurs in slightly more than half of people with the disease. * Kidney: rapidly progressive glomerulonephritis (75%), leading to chronic kidney disease * Upper airway, eye and ear disease: * Ears: conductive hearing loss due to auditory tube dysfunction, sensorineural hearing loss (unclear mechanism) * Oral cavity: strawberry gingivitis, underlying bone destruction with loosening of teeth, non-specific ulcerations throughout the lining of the mouth * Trachea: subglottal stenosis * Lungs: pulmonary nodules (referred to as "coin lesions"), infiltrates (often interpreted as pneumonia), cavitary lesions, bleeding in the lungs causing a person to cough up blood, and rarely bronchial stenosis. * Arthritis: Pain or swelling (60%), often initially diagnosed as rheumatoid arthritis * Skin: subcutaneous nodules (granulomas) on the elbow, purpura, various others (see cutaneous vasculitis) * Nervous system: occasionally sensory neuropathy (10%) and rarely mononeuritis multiplex * Heart, gastrointestinal tract, brain, other organs: rarely affected.
Granulomatosis with polyangiitis
Microscopic polyangiitis
Polyarteritis nodosa
Thromboangiitis obliterans
Eosinophilic granulomatosis with polyangiitis
Lupus vasculitis
Nephrogenic systemic fibrosis
Transplant glomerulopathy