Mechanism of action Thrombin is an enzyme that splits<unk> ogen into<unk>  monomers in 10 to 60 seconds, which aggregate to form a three-dimensional gel-like structure. Thrombin also activates factor XIII from the human body to factor XIIIa, which then cross-links the<unk>  monomers to form a stable clot. Both these processes need calcium to work. As the wound heals, the clot is slowly degraded by the enzyme plasmin. Pharmacokinetics In rabbit studies, only 1 to 2% of the applied thrombin dose reached the bloodstream. It reached highest blood plasma concentrations after 6 to 8 hours.
Fibrin glue
Polymer sponge
Angiozyme
Surgicel
Celadrin 
Tissue plasminogen activator
Surgibox
Gauze sponge