<unk>  <unk> P) is a disorder of heme biosynthesis, classified as an acute hepatic porphyria.<unk> P is caused by a deficiency of the enzyme<unk> ogen oxidase, coded for by the CPOX gene, and is inherited in an autosomal dominant fashion, although homozygous individuals have been identified. Unlike acute intermittent porphyria, individuals with<unk> P can present with cutaneous findings similar to those found in porphyria cutanea tarda in addition to the acute attacks of abdominal pain, vomiting and neurological dysfunction characteristic of acute porphyrias. Like other porphyrias, attacks of<unk> P can be induced by certain drugs, environmental stressors or diet changes. Biochemical and molecular testing can be used to narrow down the diagnosis of a porphyria and identify the specific genetic defect. Overall, porphyrias are rare diseases. The combined incidence for all forms of the disease has been estimated at 1:20,000. The exact incidence of<unk> P is difficult to determine, due to its reduced penetrance.
Hereditary coproporphyria
Hartnup disease
Acromesomelic dysplasia
Van Gogh syndrome
Schnitzler syndrome
Imperforate anus
Wildervanck syndrome
Ackerman syndrome