CNS depressants may enhance the depressant effects of<unk> , such as other opioids, anesthetics, sedatives, hypnotics, barbiturates, benzodiazepines, phenothiazines, chloral hydrate, dimenhydrinate, and glutethimide. The depressant effect of<unk>  also may be enhanced by monoamine oxidase inhibitors (MAO inhibitors), first-generation antihistamines (brompheniramine, promethazine, diphenhydramine, chlorphenamine), beta blockers, and alcohol. When combined therapy is contemplated, the dose of one or both agents should be reduced.
Hydromorphone
Oxymorphone
Morphine
Nalorphine
Ropivacaine
Butorphanol
Oxymorphol
Sufentanil