Some tests allow patients to be classified into one of two categories, “aqueous-deficient” or “hyperevaporative.” Diagnostic guidelines were published in 2007 by the<unk> <unk>  Workshop. A slit lamp examination can be performed to diagnose<unk> <unk> s and to document any damage to the<unk> . When realizing this test, the practitioner is testing the<unk> lid margin. A Schirmer's test can measure the amount of moisture bathing the<unk> . This test is useful for determining the severity of the condition. A five-minute Schirmer's test with and without anesthesia using a Whatman #41 filter paper 5 mm wide by 35 mm long is performed. For this test, wetting under 5 mm with or without anesthesia is considered diagnostic for<unk> <unk> s. If the results for the Schirmer's test are abnormal, a Schirmer II test can be performed to measure reflex secretion. In this test, the nasal mucosa is irritated with a cotton-tipped applicator, after which tear production is measured with a Whatman #41 filter paper. For this test, wetting under 15 mm after five minutes is considered abnormal. A tear breakup time (TBUT) test measures the time it takes for tears to break up in the<unk> . The tear breakup time can be determined after placing a drop of fluorescein in the cul-de-sac. A tear protein analysis test measures the lysozyme contained within tears. In tears, lysozyme accounts for approximately 20 to 40 percent of total protein content. A lactoferrin analysis test provides good correlation with other tests. The presence of the recently<unk> cribed molecule Ap4A, naturally occurring in tears, is abnormally high in different states of ocular<unk> ness. This molecule can be quantified biochemically simply by taking a tear sample with a plain Schirmer test. Utilizing this technique it is possible to determine the concentrations of Ap4A in the tears of patients and in such way diagnose objectively if the samples are indicative of<unk> <unk> . The tear osmolarity test has been proposed as a test for<unk> <unk>  disease. Tear osmolarity may be a more sensitive method of diagnosing and grading the severity of<unk> <unk>  compared to corneal and conjunctival staining, tear break-up time, Schirmer test, and meibomian gland grading. Others have recently questioned the utility of tear osmolarity in monitoring<unk> <unk>  treatment.
Dry eye syndrome
Cat eye syndrome
Ocular ischemic syndrome
Phacolytic glaucoma
Motion-induced blindness
Iridocorneal endothelial syndrome
Ghost cell glaucoma
Infiltrative ophthalmopathy