<unk>  is a common, age-related medical condition characterized by an accumulation of bone marrow plasma cells derived from a single abnormal clone. Patients may be diagnosed with<unk>  if they fulfill the following four criteria: # A monoclonal paraprotein band less than 30 g/l (< 3g/dl); # Plasma cells less than 10% on bone marrow examination; # No evidence of bone lesions, anemia, hypercalcemia, or chronic kidney disease related to the paraprotein, and # No evidence of another B-cell proliferative disorder. Differential diagnosis Several other illnesses can present with a monoclonal gammopathy, and the monoclonal protein may be the first discovery before a formal diagnosis is made: * Multiple myeloma * Smouldering multiple myeloma * AIDS * Chronic lymphocytic leukemia * Non-Hodgkin lymphoma, particularly Splenic marginal zone lymphoma and Lymphoplasmocytic lymphoma * Hepatitis C * Connective tissue disease such as lupus * Immunosuppression following organ transplantation * Waldenström macroglobulinemia * Guillain–Barré syndrome * Tempi syndrome * POEMS
Monoclonal gammopathy of undetermined significance
Monoclonal gammopathy of renal significance
AL amyloidosis
Secondary systemic amyloidosis
Familial renal amyloidosis
Waldenström macroglobulinemia
AA amyloidosis
Multiple myeloma