The symptoms of<unk>  develop over time. The onset of symptoms and how quickly they progress vary from person to person. The most common symptoms include: * Bumps under the skin located at pressure points and joints, also called subcutaneous nodules, lipogranulomas, or granulomas * Swollen, painful joints with progressive limitation of range of motion resulting in contracture * Hoarse voice/cry Other symptoms observed in some individuals with<unk>  include: * Respiratory disease, e.g. lung infections, labored breathing, respiratory distress * Central nervous system disease, e.g. developmental delay, muscle weakness, seizures * Systemic inflammation * Failure to thrive * Bone disease, e.g. erosion of bone near joints, osteoporosis, peripheral osteolysis * Enlarged liver (hepatomegaly) * Eye disease, e.g. cherry-red spot, corneal opacities
Farber disease
Keshan disease
Akureyri disease
Batten disease
Borna disease
Menkes disease
Bosch-Boonstra-Schaaf optic atrophy syndrome
Karak syndrome