The<unk>  protein mediates the adhesion of lymphocytes, monocytes, eosinophils, and basophils to vascular endothelium. It also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development of atherosclerosis and rheumatoid arthritis. Upregulation of<unk>  in endothelial cells by cytokines occurs as a result of increased gene transcription (e.g., in response to Tumor necrosis factor-alpha (TNF-α) and Interleukin-1 (IL-1)) and through stabilization of Messenger RNA (mRNA) (e.g., Interleukin-4 (IL-4)). The promoter region of the<unk>  gene contains functional tandem NF-κB (nuclear factor-kappa B) sites. The sustained expression of<unk>  lasts over 24 hours. Primarily, the<unk>  protein is an endothelial ligand for VLA-4 (Very Late Antigen-4 or integrin α4β1) of the β1 subfamily of integrins.<unk>  expression has also been observed in other cell types (e.g., smooth muscle cells). It has also been shown to interact with EZR and Moesin.<unk>  is also up regulate if vWF (Von Willebrand Factor) is given in Knock out ADMATS13 mice but not on mice withouth KO. CD106 also exists on the surface of some subpopulations of mesenchymal stem cells(MSC).
VCAM-1
Basigin
Thromboxane receptor
Collectin
NLRP3
Cll1
Cll2
Fibroblast growth factor receptor 3