In pharmacokinetics, the<unk>  (or dosing<unk>  refers not just to the<unk>  at which a drug is administered, but the desired<unk>  at which a drug should be administered to achieve a steady state of a fixed dose which has been demonstrated to be therapeutically effective. Abbreviations include Kin, K0, or R0. It can be calculated as the steady-state concentration in the plasma multiplied by the clearance:
Rate of infusion
Route of administration
Renal threshold
Position 
Cardiac output
Biological half-life
Minimum alveolar concentration
Seizure threshold