The<unk>  <unk>  is a gene<unk>  comprising over fifty genes encoding proteins involved in the terminal<unk>  and cornification of keratinocytes, the primary cell type of the epidermis. In humans, the<unk>  is located on a 1.9 Mbp stretch within chromosome 1q21. The proteins encoded by<unk>  genes are closely related in terms of function, and evolutionarily they belong to three distinct gene families: the cornified envelope precursor family, the S100 protein family and the S100 fused type protein (SFTP) family. It has been hypothesized that the clustering of<unk>  genes occurred due to duplication events which were evolutionarily favored during the adaptation to terrestrial environments.<unk>  proteins have been involved in a variety of skin disorders including ichthyosis vulgaris, atopic dermatitis and psoriasis.
Epidermal differentiation complex
Dermoepidermal junction
Neuromatrix
Growth cone
Germinal matrix
Chemosensory clusters
Inner enamel epithelium
Microkeratome