Though the cause is not well understood, the disease is thought to be due to immune system dysfunction, and particularly improper functioning of neutrophils. In support of an immune cause, a variety of immune mediators such as interleukin (IL)-8, IL-1β, IL-6, interferon (IFN)-γ, granulocyte colony-stimulating factor, tumor necrosis factor alpha, matrix metalloproteinase (MMP)-9, MMP10, and elafin have all been reported to be elevated in patients with<unk> . Also in support of an immune cause is the finding that at least half of all<unk>  patients suffer from immune-mediated diseases. For instance, ulcerative colitis, rheumatoid arthritis, and multiple myeloma (MM) have all been associated with<unk> . It can also be part of a syndromes such as PAPA syndrome. One hallmark of<unk>  is pathergy, which is the appearance of new lesions at sites of trauma, including surgical wounds.
Pyoderma gangrenosum
Ecthyma gangrenosum
Pseudomonal pyoderma
Helicobacter cellulitis
Streptococcal intertrigo
Epidermolysis bullosa
Tuberculous cellulitis
Hospital furunculosis