Currently laboratory testing is not as reliable as observation when it comes to defining the parameters of<unk> . Careful evaluation of possible thrombosis in other organ systems is pertinent in expediting treatment to prevent fatality. Preliminary diagnosis consists of evidence documented with proper imaging studies such as CT scan, MRI, or echocardiography, which demonstrate a thromboembolic occlusion in the veins and/or arteries. Vascular occlusions mentioned must include at least two of the clinic events: * Deep venous thrombosis affecting one (or more) limbs and/or pulmonary embolism. * Cerebral vein thrombosis. * Portal vein thrombosis, hepatic vein, or other intra-abdominal thrombotic events. * Jugular vein thrombosis in the absence of ipsilateral arm vein thrombosis and in the absence of ipsilateral central venous access. * Peripheral arterial occlusions, in the absence of underlying atherosclerotic vascular disease, * resulting in extremity ischemia and/or infarction. * Myocardial infarction, in the absence of severe coronary artery disease * Stroke and/or transient ischemic attack, in the absence of severe atherosclerotic disease and at an age less than 60 years. * Central retinal vein and/or central retinal arterial thrombosis. * Small vessel thrombosis affecting one or more organs, systems, or tissue; must be documented by histopathology. In addition to the previously noted vascular occlusions, development of different thromboembolic manifestations simultaneously or within one or two weeks must occur and the patient must have an underlying inherited or acquired hypercoagulable state (other than Antiphospholipid syndrome) Hypercoagulable states Congenital Acquired Protein C deficiency CAPS Protein S deficiency Autoimmune Disorder i.e. APS Factor V Leiden Illness that causes or promote tissue necrosis Prothrombin Mutation Malignancy Antithrombin Deficiency Pregnancy Immobility Surgery Trauma Thrombocytopenic Purpura
Thrombotic storm
Post-thrombotic syndrome
Fibrinolysis syndrome
Septic embolism
Cerebral hyperperfusion syndrome
Coronary thrombosis
Deep vein thrombosis
Tumor lysis syndrome