Estimates are that in 2018, 18.1 million new<unk> ses of<unk>  and 9.6 million deaths occur globally. About 20% of males and 17% of females will get<unk>  at some point in time while 13% of males and 9% of females will die from it. In 2008, approximately 12.7 million<unk> s were diagnosed (excluding non-melanoma skin<unk> s and other non-invasive<unk> s) and in 2010 nearly 7.98 million people died.<unk> s account for approximately 16% of deaths. The most common are lung<unk>  (1.76 million deaths), colorectal<unk>  (860,000) stomach<unk>  (780,000), liver<unk>  (780,000), and breast<unk>  (620,000). This makes invasive<unk>  the leading<unk> use of death in the developed world and the second leading in the developing world. Over half of<unk> ses occur in the developing world. Deaths from<unk>  were 5.8 million in 1990. Deaths have been increasing primarily due to longer lifespans and lifestyle changes in the developing world. The most significant risk factor for developing<unk>  is age. Although it is possible for<unk>  to strike at any age, most patients with invasive<unk>  are over 65. According to<unk>  researcher Robert A. Weinberg, "If we lived long enough, sooner or later we all would get<unk> ." Some of the association between aging and<unk>  is attributed to immunosenescence, errors accumulated in DNA over a lifetime and age-related changes in the endocrine system. Aging's effect on<unk>  is complicated by factors such as DNA damage and inflammation promoting it and factors such as vascular aging and endocrine changes inhibiting it. Some slow-growing<unk> s are particularly common, but often are not fatal. Autopsy studies in Europe and Asia showed that up to 36% of people have undiagnosed and apparently harmless thyroid<unk>  at the time of their deaths and that 80% of men develop prostate<unk>  by age 80. As these<unk> s do not<unk> use the patient's death, identifying them would have represented overdiagnosis rather than useful medical<unk> re. The three most common childhood<unk> s are leukemia (34%), brain tumors (23%) and lymphomas (12%). In the United States<unk>  affects about 1 in 285 children. Rates of childhood<unk>  increased by 0.6% per year between 1975 and 2002 in the United States and by 1.1% per year between 1978 and 1997 in Europe. Death from childhood<unk>  decreased by half between 1975 and 2010 in the United States.
Cancer
Anorexia nervosa
Disease
Heartburn
Cardiovascular disease
Vaginitis
Skin cancer
Neuropathic pain