<unk>  has been reported as a substrate for OATP1B1 and OATP1B3. Interaction of<unk>  with OATP1B1 and OATP1B3 may alter its hepatic disposition and can lead to transporter mediated drug-drug interactions.<unk>  is an inhibitor of OATP-1B1 transporter but not for OATP-1B3. It is a substrate for CYP3A4 and hence grapefruit juice and other CYP3A4 inhibitors will increase its action and inducers like St. John's wort will decrease it. Patients report that pomegranates and starfruit may also interfere. Food should not be eaten two hours before or one hour afterwards because it unpredictably increases its bioavailability, approximately doubling it.
Nilotinib
Icotinib
Crizotinib
Tepotinib
Afatinib
Erlotinib
Axitinib
Imatinib