<unk>  does not appear to affect life expectancy, although the latest study on the topic is from 1985. The main impact is on quality of life; many people with<unk>  have disabling symptoms such as pain, poor sleep, and breathing symptoms. These generally start in the fourth decade. The typical age at requiring joint replacement surgery is 50–55 years.
Alkaptonuria
Hawkinsinuria
Orotic aciduria
Cystathioninuria
Aspartylglucosaminuria
Homocystinuria
Urocanic aciduria
Glycosuria