Current standard for<unk> g multiple sclerosis (MS) is based in the 2018 revision of McDonald criteria. They rely in MRI detection (or clinical demonstration) of demyelinating lesions in the CNS, which are distributed in space (DIS) and in time (DIT). It is also a requirement that any possible known disease that produces demyelinating lesions is ruled out before applying McDonald's criteria. This last requirement makes MS an ill-defined entity, whose borders change every time that a new disease is set apart. Some previous cases considered MS are now considered apart, like Neuromyelitis optica or antiMOG associated encephalomyelitis. Besides, because of the requirement of distributed lesions, a single lesion (RIS) is not considered MS. For the same reason, the prodromal stage of MS (the unknown condition that causes the lesions) would not be considered as MS if it could be found. Sometimes the<unk>  must be retrospective, relying on gradual worsening of neurological signs/symptoms, due to the lack of understanding of the pathogenicity driving disease progression. However, the only definite<unk>  of MS is post-mortem autopsy, where lesions typical of MS can be detected through histopathological techniques.
Multiple sclerosis diagnosis
Multiple sclerosis signs and symptoms
symptom of Brain tumor
Cancer cluster
symptom of Meningioma
Multiple sclerosis biomarkers
symptom of Tuberculous meningitis
symptom of Glioblastoma