<unk>  is the spontaneous detachment (amputation) of an appendage or organ from the body. This is not to be confused with self-amputation. It is usually due to destruction of the blood vessels feeding an extremity such as the finger tips. Once the vessels are destroyed, the tissue is starved of oxygen and dies, which is often followed by gangrene.<unk>  is a feature of ainhum, cryoglobulinemia and thromboangiitis obliterans. In 1881, Thornton made the case of<unk> .<unk>  could be the result of severe cases of certain chronic wounds, such as frostbite. These chronic wounds might be due to some vascular and pathogenic conditions like Buerger disease or Reynaud's phenomenon. Also, uncontrolled diabetes can predispose one to<unk> . However,<unk>  has been described as spontaneous.<unk>  has often been associated with fingers and toes but other parts of the body can suffer this condition as well. There have been reported cases of ovarian<unk>  in a newborn and also in a mature ovary of adults.<unk>  has been reported to affect the tip of fingers. Though<unk>  is often regarded as an acquired ailment, it could also be congenital. Chronic torsion or a delay in the diagnosis of acute adnextal torsion has been attributed as causes of acquired<unk>
Autoamputation
Somatic hypermutation
Osseoincorporation
Paramutation
Chromosomal translocation
Cross-tolerance
Self-enucleation
Antigenic escape