<unk>  (apolipoprotein B mRNA editing enzyme, catalytic subunit 3G) is a human enzyme encoded by the<unk>  gene that belongs to the APOBEC superfamily of proteins. This family of proteins has been suggested to play an important role in innate anti-viral immunity.<unk>  belongs to the family of cytidine deaminases that catalyze the deamination of cytidine to uridine in the single stranded DNA substrate. The C-terminal domain of A3G renders catalytic activity, several NMR and crystal structures explain the substrate specificity and catalytic activity.<unk>  exerts innate antiretroviral immune activity against retroviruses, most notably HIV, by interfering with proper replication. However, lentiviruses such as HIV have evolved the Viral infectivity factor (Vif) protein in order to counteract this effect. Vif interacts with<unk>  and triggers the ubiquitination and degradation of<unk>  via the proteasomal pathway. On the other hand, foamy viruses produce an accessory protein Bet () that impairs the cytoplasmic solubility of<unk> . The two ways of inhibition are distinct from each other, but they can replace each other in vivo.
APOBEC3G
GP1BA
GP1BB
PHKA2
PIM2
TOFI
CoWIN
STAR*D