<unk>  is a potentially dangerous natural compound; the US Food and Drug Administration had received over 18,000 reports of adverse effects in people using it. Adverse drug reactions (ADRs) are more common with systemic administration (e.g. injection or oral administration) compared to topical administration (e.g. nasal instillations). ADRs associated with<unk>  therapy include: *Cardiovascular: tachycardia, cardiac arrhythmias, angina pectoris, vasoconstriction with hypertension *Dermatological: flushing, sweating, acne vulgaris *Gastrointestinal: nausea *Genitourinary: decreased urination due to vasoconstriction of renal arteries, difficulty urinating is not uncommon, as alpha-agonists such as<unk>  constrict the internal urethral sphincter, mimicking the effects of sympathetic nervous system stimulation *Nervous system: restlessness, confusion, insomnia, mild euphoria, mania/hallucinations (rare except in previously existing psychiatric conditions), delusions, formication (may be possible, but lacks documented evidence) paranoia, hostility, panic, agitation *Respiratory: dyspnea, pulmonary edema *Miscellaneous: dizziness, headache, tremor, hyperglycemic reactions, dry mouth The neurotoxicity of l-ephedrine is disputed.
Ephedrine
Pseudoephedrine
Tesofensine
Eptazocine
Dezocine
Naloxone
Butalbital
Bremazocine