Mitochondrial inheritance The cause of<unk>  disorder is due to mutations in the mitochondrial genome. This means that it is a pathological variant in mtDNA (mitochondrial DNA) and is transmitted by maternal inheritance. Four point mutations in the genome can be identified that are associated with<unk> : m.A8344G, m.T8356C, m.G8361A, and m.G8363A. The point mutation m.A8344G is most commonly associated with<unk> , in a study published by Paul Jose Lorenzoni from the Department of neurology at University of Panama stated that 80% of the patients with<unk>  disease exhibited this point mutation. This point mutation disrupts the mitochondrial gene for tRNA-Lys. This disrupts the synthesis of proteins. The remaining mutations only account for 10% of cases, and the remaining 10% of the patients with<unk>  did not have an identifiable mutation in the mitochondrial DNA. Many genes are involved. These genes include: * MT-TK * MT-TL1 * MT-TH * MT-TS1 * MT-TS2 * MT-TF It involves the following characteristics: * progressive myoclonic epilepsy * "Ragged Red Fibers" - clumps of diseased mitochondria accumulate in the subsarcolemmal region of the muscle fiber and appear as "Ragged Red Fibers" when muscle is stained with modified Gömöri trichrome stain. There is currently no cure for<unk> .
MERRF syndrome
Hagemoser–Weinstein–Bresnick syndrome
VEXAS syndrome
Hughes–Stovin syndrome
Smith–Fineman–Myers syndrome
Crome syndrome
RIDDLE syndrome
3-M syndrome