Heparan sulfate is one of the GAGs that builds up in the lysosomes of people with<unk>  The IDUA gene is responsible for encoding an enzyme called alpha-L-iduronidase. Through hydrolysis, alpha-L-iduronidase is responsible for breaking down a molecule called unsulfated alpha-L-iduronic acid. This is a uronic acid found in the GAGs dermatan sulfate and heparan sulfate. The alpha-L-iduronidase enzyme is located in lysosomes. Without sufficient enzymatic function, these GAGs cannot be digested properly.
Hurler syndrome
Hunter syndrome
Kindler syndrome
Mucopolysaccharidosis
Birk-Barel syndrome
Hurler–Scheie syndrome
Pelger–Huët anomaly
Scheie syndrome