<unk>  or<unk>  chemotherapy is a four-drug combination chemotherapy<unk> , used today in the treatment of Hodgkin lymphoma. It was one of the earliest combination chemotherapy<unk> s, originally developed as a treatment for childhood leukemia by a group of researchers at the National Cancer Institute led by Emil Frei and Emil Freireich. The first clinical trial of<unk>  began in 1961. Because it was the first time that four chemotherapeutic agents were used at once, the trial was highly controversial at its time. Although new combination chemotherapy<unk> s have replaced the use of<unk>  in the treatment of childhood leukemia,<unk>  is considered an important precursor to modern treatments, confirming the effectiveness of combination chemotherapy and leading to the use of combination chemotherapy<unk> s to treat other types of cancer. The<unk>  developed by Freireich and Frei was a combination of vincristine, amethopterin, mercaptopurine, and prednisone. Now, other combinations and doses that are referred to as<unk> , including C-VAMP and a<unk>  that replaces the mercaptopurine of the original combination with doxorubicin. All these<unk> s take advantage of the synergistic effects of combining multiple chemotherapy agents.
VAMP regimen
Metronomic therapy
Proton therapy
Stamina therapy
Destination therapy
Breakthrough therapy
Polio eradication
Carboxytherapy