A 1680 painting by Juan Carreño de Miranda of a girl presumed to have Prader-Willi syndrome Like many other medical conditions, obesity is the result of an interplay between environmental and<unk> factors. Studies have identified variants in several genes that may contribute to weight gain and body fat distribution; although, only in a few cases are genes the primary cause of obesity. Polymorphisms in various genes controlling appetite and metabolism predispose to obesity under certain dietary conditions. The percentage of obesity that can be attributed to<unk>  varies widely, depending on the population examined, from 6% to 85%. As of 2006, more than 41 sites on the human genome have been linked to the development of obesity when a favorable environment is present. The involvement of<unk> factors in the development of obesity is estimated to be 40–70%. Some of these obesogenic or leptogenic genes may influence the obese individual's response to weight loss or weight management.
Genetics of obesity
Social determinants of obesity
Epidemiology of obesity
Genetic causes of type 2 diabetes
Classification of obesity
Pathophysiology of obesity
Epidemiology of childhood obesity
Dietary energy supply