<unk> in the context of chemotherapy is an acronym for one of the chemotherapy regimens, used in salvage treatment of relapsed or refractory non-Hodgkin's lymphoma and Hodgkin lymphoma. In case of CD20-positive B cell lymphoid malignancies the<unk> regimen is often combined today with rituximab. This regimen is then called<unk> R or R-ICE or RICE. R-ICE regimen consists of: # Rituximab - an anti-CD20 monoclonal antibody, which is able to kill both normal and malignant CD20-bearing B cells; # Ifosfamide - an alkylating antineoplastic agent of the oxazafosforine group; # Carboplatin - a platinum-based antineoplastic drug, also an alkylating antineoplastic agent; # Etoposide - a topoisomerase inhibitor.
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