Instead of binding to consensus sequences of target gene promoters, like conventional transcription factors,<unk>  engages in coordinated sequences that are performed by its multimolecular complexes. The first<unk>  partner that was identified is the CREB-binding protein (CBP) that is localized in nuclear bodies and is a co-activator of many transcription factors. Other<unk>  partners include positive transcription elongation factor b (P-TEFb) and DNA activated protein kinase (DNA-PK). DNA-PK phosphorylates<unk>  in vitro at Thr68 and Ser156. Another partner is DNA-topoisomerase (DNA-TOP) IIα. This isomerase enzyme works on DNA topology and removes positive and negative DNA supercoils by causing transient DNA breaks. In turn, this causes relaxation of local chromatin and helps the initiation and post-initiation events of gene transcription. By performing double-stranded DNA breaks, DNA-TOPIIα recruits DNA-PK and poly-(ADP-ribose) polymerase (PARP1) which are involved in DNA break and repair through non-homologous end joining.
Autoimmune regulator
Inflammatory cytokine
Lymphokine
Tumor antigen
Cytokine
Bacterial adhesin
Autoantibody
Microantibody