α6β4 integrin is a transmembrane protein found in hemidesmosomes. As a heterodimer molecule containing two polypeptide chains its extracellular domain enters the basal lamina and interacts with type IV collagen suprastructure containing laminins (laminin-5), entactin/nidongen or the perlecan. on the extracellular surface of the hemidesmosome, laminin-5 molecules form threadlike anchoring filaments that extend from the integrin molecules to the structure of the basement membrane of epithelial adhesion. Mutation of the genes encoding laminin-5 chains results in<unk>
Junctional epidermolysis bullosa 
Epidermolysis bullosa acquisita
Epidermolysis bullosa
Epidermolysis bullosa simplex
Dyskeratosis congenita
Linitis plastica
Epidermolysis bullosa dystrophica
Epidermodysplasia verruciformis