The structural formula of tetrahydrocannabinol. Tetrahydrocannabivarin.<unk> iol.<unk> ol.<unk> arin.<unk> ivarin.<unk> oids and<unk> oid receptors The most prevalent psychoactive substances in<unk>  are<unk> oids, particularly THC. Some varieties, having undergone careful selection and growing techniques, can yield as much as 34% THC. Another psychoactive<unk> oid present in<unk>  sativa is tetrahydrocannabivarin (THCV), but it is only found in small amounts and is a<unk> oid antagonist. There are similar compounds in<unk>  that do not exhibit psychoactive response but are obligatory for functionality:<unk> iol (CBD), an isomer of THC;<unk> arin (CBV), an analog of<unk> ol (CBN) with a different side chain,<unk> ivarin (CBDV), an analog of CBD with a different side chain, and<unk> olic acid. CBD is believed to regulate the metabolism of THC by inactivating cytochrome P450 enzymes that metabolize drugs; one such mechanism is via generation of carbon monoxide (a pharmacologically active neurotransmitter) by upon metabolism of CBD. THC is converted rapidly to 11-hydroxy-THC, which is also pharmacologically active, so the euphoria outlasts measurable THC levels in blood. Biochemical mechanisms in the brain<unk> oids usually contain a 1,1'-di-methyl-pyran ring, a variedly derivatized aromatic ring and a variedly unsaturated cyclohexyl ring and their immediate chemical precursors, constituting a family of about 60 bi-cyclic and tri-cyclic compounds. Like most other neurological processes, the<unk>  on the brain follow the standard protocol of signal transduction, the electrochemical system of sending signals through neurons for a biological response. It is now understood that<unk> oid receptors appear in similar forms in most vertebrates and invertebrates and have a long evolutionary history of 500 million years. The binding of<unk> oids to<unk> oid receptors decrease adenylyl cyclase activity, inhibit calcium N channels, and disinhibit K+A channels. There are at least two types of<unk> oid receptors (CB1 and CB2). Sustainability in the body Most<unk> oids are lipophilic (fat soluble) compounds that are easily stored in fat, thus yielding a long elimination half-life relative to other recreational drugs. The THC molecule, and related compounds, are usually detectable in drug tests from 3 days up to 10 days according to Redwood Laboratories. Long-term users can produce positive tests for two to three months after ceasing<unk>  use (see drug test).
Effects of cannabis
Amphetamine dependence
Drug withdrawal
Opioid withdrawal
Nicotine withdrawal
Benzodiazepine dependence
Psychedelic microdosing
Substance intoxication