<unk>  <unk>  is an extremely rare genetic disorder, and is one of the RASopathies. It was first described in 1986. It is characterized by the following: *Distinctive facial appearance *Unusually sparse, brittle, curly scalp hair *A range of skin abnormalities from dermatitis to thick, scaly skin over the entire body (generalized ichthyosis) *Heart malformations in over 75% of patients (congenital or appearing later), especially an obstruction of the normal flow of blood from the lower right ventricle of the heart to the lungs (valvar pulmonary stenosis) *Growth delays *Feeding problems associated with severe gastroesophageal reflux disease (GERD) *Foot abnormalities (extra toe or fusion of two or more toes) *Intellectual disability *Failure to thrive
Cardiofaciocutaneous syndrome
Oculofaciocardiodental syndrome
Oto-palato-digital syndrome
Oculocerebrocutaneous syndrome
Pork–cat syndrome
Tooth and nail syndrome
Zechi-Ceide syndrome
Progeroid syndromes