<unk>  is an unusual reaction seen almost exclusively in patients from the Caribbean and Mexico with diffuse lepromatous leprosy, especially in untreated cases. It is characterised by recurrent crops of large, sharply demarcated, ulcerative lesions, affecting mainly the lower extremities, but may generalise and become fatal as a result of secondary bacterial infection and sepsis.<unk>  was first described by Rafael<unk>  Nájera and Alvarado as a necrotizing skin reaction associated with non-nodular diffuse leprosy in 1852. This reaction was later named by Latapi and Zamora in 1948 as<unk>  after identification of histopathological changes involving multiple, acute and necrotizing cutaneous vasculitis peculiar to pure and primitive diffuse leprosy (PPDL).
Lucio's phenomenon
Bell's phenomenon
Uhthoff's phenomenon
Waddell's signs
Brudziński's sign
Kohnstamm's phenomenon
Borsari's sign
Baastrup's sign