Mechanism of action Pharmacokinetics Neither<unk>  etabonate nor its inactive metabolites Δ1-cortienic acid and Δ1-cortienic acid etabonate are detectable in the bloodstream, even after oral administration. A study with patients receiving<unk>  eye drops over 42 days showed no adrenal suppression, which would be a sign of the drug reaching the bloodstream to a clinically relevant extent. Steroid receptor affinity was 4.3 times that of dexamethasone in animal studies. Retrometabolic drug design<unk>  etabonate was developed using retrometabolic drug design. It is a so-called soft drug, meaning its structure was designed so that it is predictably metabolised to inactive substances. These metabolites, Δ1-cortienic acid and its etabonate, are derivatives of cortienic acid, itself an inactive metabolite of hydrocortisone. File:Cortisol2.Cortisol, a naturally occurring corticosteroid, known as hydrocortisone when used as a drug File:Delta1-cortienic acid skeletal.Δ1-Cortienic acid, inactive metabolite of<unk>  File:Cortienic acid skeletal.Cortienic acid, inactive metabolite of hydrocortisone
Loteprednol
Avacopan
Agomelatine
Bocasan
Stiripentol
Atogepant
Tropisetron
Fenproporex