Criteria for the clinically defined diagnosis of<unk>  have not been strictly set forth. Diagnosis must first rule out other causes of eosinophilia and hypereosinophilia, such as those due to allergies, drug reactions, infestations, and autoimmune diseases as well as those associated with eosinophilic leukemia, clonal eosinophilia, systemic mastocytosis, and other malignancies (see causes of eosinophilia). Criteria for the diagnosis include findings of: a) long term hypereosinophila (i.e. eosinophil blood counts >1,500/microliter) plus physical findings and symptoms associated with the disease; b) bone marrow analysis showing abnormally high levels of eosinophils; c) elevated serum levels of Immunoglobulin E, other immunoglobulins, and CCL17; d) eosinophil infiltrates in afflicted tissues; e) increased numbers of blood and/or bone marrow T cells bearing abnormal immunophenotype cluster of differentiation markers as defined by fluorescence-activated cell sorting (see above section on Pathogenesis); f) abnormal T cell receptor arrangements as defined by polymerase chain reaction methods (see above section on Pathogenesis); and g) evidence of excessive IL-5 secretion by<unk> s (see above section on Pathogenesis). In many clinical settings, however, studies on the T cell receptor and IL-5 are not available and therefore not routine parts of the diagnostic work-up or criteria for the disease. The finding of T cells bearing abnormal immunophenotype cluster of differentiation markers is critical to making the diagnosis.
Lymphocyte-variant hypereosinophilia
Tropical eosinophilia
Drug reaction with eosinophilia and systemic symptoms
Clonal hypereosinophilia
Diffuse infiltrative lymphocytosis syndrome
Familial eosinophilia
Hypereosinophilic syndrome
IgA vasculitis