Leukemic<unk> s are invariably present in samples of peripheral blood to a variable extent. Pancytopenia (anemia, neutropenia, thrombocytopenia) is commonly seen as well. Peripheral blood The leukemic<unk> s have a diameter mildly greater than a large granular lymphocyte (LGL) and have azurophilic granules and nucleoli of varying prominence. Nuclei may be irregular and hyperchromatic. Bone marrow Bone marrow involvement runs the spectrum between an inconspicuous infiltrate to extensive marrow replacement by leukemic<unk> s. Reactive histiocytes displaying hemophagocytosis can be seen interspersed in the neoplastic infiltrate. Other organs Leukemic involvement of organs is typically destructive on tissue sections with necrosis and possibly angioinvasion, and the monotonous infiltrate may be diffuse or patchy. Immunophenotype The immunophenotype of this disease is the same as extranodal<unk> /T-cell lymphoma, nasal type and is shown in the table below. CD11b and CD16 show variable expression. Status Antigens Positive CD2, CD3ε, CD56, perforin, granzyme B, TIA-1, CCR5 Negative CD57 Genetic findings Due to the<unk>  lineage, clonal rearrangements of lymphoid (T<unk>  receptor; B<unk>  receptor) genes are not seen. The genome of the Epstein Barr virus (EBV) is detected in many cases, along with a variety of chromosomal abnormalities.
Aggressive NK-cell leukemia
Precursor T-lymphoblastic lymphoma
Blastic plasmacytoid dendritic cell neoplasm
Angioimmunoblastic T-cell lymphoma
Peripheral T-cell lymphoma
B-cell prolymphocytic leukemia
T-cell prolymphocytic leukemia
Precursor B-cell lymphoblastic leukemia