Taking erythromycin or ketoconazole while taking<unk>  does increase the plasma levels of<unk> , but this increase does not influence the QT interval. The reason for this effect is likely due to transport-related effects, specifically involving p-glycoprotein (p-gp). Both erythromycin and ketoconazole are inhibitors of p-gp, a transporter protein involved in preventing the intestinal absorption of<unk> . When p-gp is inhibited,<unk>  may be better absorbed by the body, increasing its plasma concentration by more than intended.<unk>  is not to be taken with apple, orange, or grapefruit juice because they could decrease absorption of the drug. Therefore, it should be taken with water. Grapefruit juice can significantly reduce the plasma concentration of<unk> . Antacids containing aluminum or magnesium should not be taken within 15 minutes of<unk> , as they reduce its absorption by almost 50%. This is not thought to be due to a change in pH (in fact, absorption can actually increase under increasingly alkaline pH), but rather due to the formation of metal complexes with charged/polar moieties on<unk> . As suggested by Shehnaza et al (2014), various sites of the molecule are thought to be responsible for this interaction, including the piperidine nitrogen, the carboxylic acid (-COOH) group, and both hydroxyl (-OH) groups.
Fexofenadine
Ecallantide
Cetirizine
Terfenadine
Anakinra
Budesonide
Mibolerone
Ciclopirox