<unk>  availability is significantly affected by the CYP3A4 and CYP3A5 enzymes. Medications that inhibit or induce those enzymes change the amount of<unk>  in circulation and thus its efficacy and rate of adverse effects. Because of its impact on the heart, it should be used with caution with other cardioactive drugs. Similar concern is appropriate when it is used with sedating medications.<unk>  is known to lower the user's tolerance for alcohol, heightening its effect, and alcohol use may prolong the effects of the medication.
Guanfacine
Nabilone
Atomoxetine
Naltrexone
Mianserin
Vilazodone
Trazodone
Nortriptyline