Mechanism of action<unk>  blocks the actions of angiotensin II, which include constricting blood vessels and activating aldosterone, to reduce blood pressure. The drug binds to angiotensin type I receptors (AT1), working as an antagonist. This mechanism of action is different than that of the ACE inhibitor drugs, which block the conversion of angiotensin I to angiotensin II. As<unk>  acts at the receptor, it can provide more complete angiotensin II antagonism since angiotensin II is generated by other enzymes as well as ACE. Also,<unk>  does not affect the metabolism of bradykinin like ACE inhibitors do. Pharmacodynamics Pharmacokinetics AUC and Cmax<unk> ues of<unk>  are observed to be approximately linearly dose-dependent over therapeutic dosing range. Owing to its relatively short elimination half life attribution,<unk>  concentration in plasma doesn't accumulate in response to repeated dosing.
Valsartan
Olmesartan
Losartan
Azilsartan
Telmisartan
Irbesartan
Candesartan
Cyclothiazide