In most ethnic groups, the prevalence of<unk>  is between 1:100,000 and 1:250,000. In Slovakia and the Dominican Republic, the disease is much more common, with prevalence estimated at 1:19,000 people. As for Slovakia, this is not the result of a single mutation, but due to a group of 12 mutations in specific "hot spots" of the HGD gene. The Slovakian clustering probably arose in a small area in the northwest of the country and spread after the 1950s due to migration.
Alkaptonuria
Hawkinsinuria
Orotic aciduria
Cystathioninuria
Aspartylglucosaminuria
Homocystinuria
Urocanic aciduria
Glycosuria