The various symptoms of EA are caused by dysfunction of differing areas.<unk> , the most common symptom, is due to misfiring of Purkinje cells in the cerebellum. This is either due to direct malfunction of these cells, such as in EA2, or improper regulation of these cells, such as in EA1. Seizures are likely due to altered firing of hippocampal neurons (KCNA1 null mice have seizures for this reason).
Episodic ataxia
Myopathic gait
Holmes tremor
Parkinsonian gait
Pseudoathetosis
Periodic paralysis
Paroniria
Chorea 