<unk>  plays many different roles in the cell depending on which tissue in which it is expressed. ColVI maintains a mechanical function in the cell, which is typical of most types of Collagen, by providing stability and structural support in the ECM. ColVI allows muscle cells to connect with the ECM by interacting with perlecan in the basal lamina. ColVI also functions as a cytoprotective agent: # ColVI plays an important role in cancer by acting as a chemotherapy resistance modulator. #ColVI inhibits oxidative damage and apoptosis. #ColVI regulates cell differentiation and autophagic machinery. # With the assistance of other collagens, proteoglycans, matrilineal, fibronectins, and glycoproteins, ColVI anchors the basement membrane of the skin to the extracellular matrix.
Collagen VI
Type V collagen
Collectin
Basigin
Desmoglein
Apamin
Embelin
Equilin