<unk> , similarly to other SSRIs, inhibits CYP2D6 and hence may increase plasma levels of a number of CYP2D6 substrates such as aripiprazole, risperidone, tramadol, codeine, etc. As<unk>  is only a weak inhibitor of CYP2D6, analgesia from tramadol may not be affected.<unk>  should be taken with caution when using St. John's wort. Exposure to<unk>  is increased moderately, by about 50%, when it is taken with omeprazole. The authors of this study suggested that this increase is unlikely to be of clinical concern. Caution should be used when taking cough medicine containing dextromethorphan (DXM) as serotonin syndrome has been reported. Bupropion has been found to significantly increase citalopram plasma concentration and systemic exposure; the interaction with<unk>  had not been studied, but some monographs warned of the potential interaction.<unk>  can also prolong the QT interval and hence it is not recommended in patients that are concurrently on other medications that also have the ability to prolong the QT interval. These drugs include antiarrhythmics, antipsychotics, tricyclic antidepressants, some antihistamines (astemizole, mizolastine) and some antiretrovirals (ritonavir, saquinavir, lopinavir). As an SSRI,<unk>  should generally not be given concurrently with MAOIs.
Escitalopram
Citalopram
Atomoxetine
Sertraline
Bupropion
Dapoxetine
Fluoxetine
Duloxetine