<unk>  is a third-generation antibiotic from the cephalosporin family of antibiotics. It is within the β-lactam family of antibiotics.<unk>  selectively and irreversibly inhibits bacterial cell wall synthesis by binding to transpeptidases, also called transamidases, which are penicillin-binding proteins (PBPs) that catalyze the<unk> ss-linking of the peptidoglycan polymers forming the bacterial cell wall. The peptidoglycan cell wall is made up of pentapeptide units attached to a polysaccharide backbone with alternating units of N-acetylglucosamine and N-acetylmuramic acid. PBPs act on a terminal D-alanyl-D-alanine moiety on a pentapeptide unit and catalyze the formation of a peptide bond between the penultimate D-alanine and a glycine unit on an adjacent peptidoglycan strand, releasing the terminal D-alanine unit in the process. The structure of<unk>  mimics the D-alanyl-D-alanine moiety, and the PBP attacks the beta-lactam ring in<unk>  as if it were its normal D-alanyl-D-alanine substrate. The peptidoglycan<unk> ss-linking activity of PBPs is a construction and repair mechanism that normally helps to maintain bacterial cell wall integrity, so the inhibition of PBPs leads to damage and destruction of the cell wall and eventually to cell lysis.
Ceftriaxone
Meropenem
Levofloxacin
Cefotaxime
Azithromycin
Cefepime
Vancomycin
Ampicillin