An immune-mediated component to FOSMN has been suggested based on the response to treatment but so far this has only been described in a single patient. The specific neuronal subtypes involved in the disease are not clear. Although most features of FOSMN reflect lower motor neuron impairment some findings have suggested upper motor neuron impairment in FOSMN. Involvement of both UMN and LMN might suggest a link between FOSMN and other, better characterised diseases such as amyotrophic lateral sclerosis.
Facial onset sensory and motor neuropathy
Progressive bulbar palsy
Tropical neuropathy
Multifocal motor neuropathy
Diabetic neuropathy
Subacute myelo-optic neuropathy
Recurrent painful ophthalmoplegic neuropathy
Acute motor axonal neuropathy