<unk>  also known as the BB or BBDP<unk>  is an inbred laboratory<unk>  strain that spontaneously develops autoimmune Type 1 Diabetes. Like the NOD mice,<unk> s are used as an animal model for Type 1 diabetes. The strain re-capitulates many of the features of human type 1 diabetes, and has contributed greatly to the research of T1D pathogenesis. Two T1D susceptibility genes have been identified in the<unk> . The susceptible MHC class II RT1u haplotype on chromosome 20 and a null mutation in the GIMAP5 gene on chromosome 4. The Gimap5 mutation results in severe T cell lymphopenia in the<unk>  and is thought to contribute to T1D pathogenesis through impaired development and function and regulatory T cells. Recently, 8 additional loci on<unk>  chromosomes 1,2,3,6 (2 loci), 12 and 14 have been shown to be linked to Type 1 Diabetes in the<unk> .
Biobreeding rat
Florida shuffle
Nude mouse
Litter 
Cold turkey
Louse-feeder
Charley horse
Harvey mannequin