<unk>  (NSML) which is part of a group called Ras/MAPK pathway syndromes, is a rare autosomal dominant, multisystem disease caused by a mutation in the protein tyrosine phosphatase, non-receptor type 11 gene (PTPN11). The disease is a complex of features, mostly involving the skin, skeletal and cardiovascular systems, which may or may not be present in all patients. The nature of how the mutation causes each of the condition's symptoms is not well known; however, research is ongoing. It is a RASopathy.<unk>  is caused by a different missense mutation of the same gene.<unk>  syndrome is fairly common (1:1,000 to 1:2,500 live births), and neurofibromatosis 1 (which was once thought to be related to NSML) is also common (1:3500); however, no epidemiological data exists for NSML.
Noonan syndrome with multiple lentigines
Multiple hamartoma syndrome
Hemihyperplasia–multiple lipomatosis syndrome
Sabinas brittle hair syndrome
Tuber cinereum hamartoma
Acorea, microphthalmia and cataract syndrome
Pure hair-nail type ectodermal dysplasia
Lenz microphthalmia syndrome