Grade 1 hypertension The<unk> , also known as ALLHAT, was a randomized, double-blind, active-controlled study comparing at the same time, four different classes of<unk>  drugs with the rate of coronary<unk>  disease (CHD) events in ‘high-risk’ people with hypertension. Participants were initially randomised to chlorthalidone (diuretic) versus doxazosin (alpha-adrenergic blocker), lisinopril (ACE-inhibitor), and amlodipine (calcium channel blocker). The doxazosin arm was discontinued early on in the<unk>  because of a higher rate of combined cardiovascular events and admissions for<unk>  failure compared with chlorthalidone. The study concluded that major CHD events did not differ between initial use of chlorthalidone versus lisinopril or amlodipine. As a result, the Joint National Committee (7) guidelines of 2003, recommended the cheaper but equally effective diuretics as a first line treatment for hypertension. The study also confirmed the previously held views that ACE inhibitors were less effective in blood pressure control and stroke<unk> ion in men of African and Caribbean descent.
Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial
HDL-Atherosclerosis Treatment Study
Estrogen in Venous Thromboembolism Trial
Comparison of international blood pressure guidelines
Atherosclerosis Risk in Communities
West of Scotland Coronary Prevention Study
Bypass surgery
Totally endoscopic coronary artery bypass surgery