The<unk>  belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other<unk> s <unk> -hydroxytryptamine, or serotonin) receptors which are G protein-coupled receptors. This ion channel is cation-selective and mediates neuronal depolarization and excitation within the central and peripheral nervous systems. As with other ligand gated ion channels, the<unk>  consists of five subunits arranged around a central ion conducting pore, which is permeable to sodium (Na), potassium (K), and calcium (Ca) ions. Binding of the neurotransmitter<unk> -hydroxytryptamine (serotonin) to the<unk>  opens the channel, which, in turn, leads to an excitatory response in neurons. The rapidly activating, desensitizing, inward current is predominantly carried by sodium and potassium ions.<unk> s have a negligible permeability to anions. They are most closely related by homology to the nicotinic acetylcholine receptor.
5-HT3 receptor
Muscarinic acetylcholine receptor M4
Baroreceptor
Trace amine-associated receptor
Prolactin-releasing peptide receptor
SK channel
Hydroxycarboxylic acid receptor 2
Norepinephrine transporter