Two theories exist to explain the molecular mechanism of action of<unk>  with DNA: *Aquation, or the like-cisplatin hypothesis. *Activation, or the unlike-cisplatin hypothesis. The former is more accepted owing to the similarity of the leaving groups with its predecessor cisplatin, while the latter hypothesis envisages a biological activation mechanism to release the active Pt2+ species.
Carboplatin
Ifosfamide
Lipoplatin
Vincristine
Etoposide
Doxorubicin
Lomustine
Epirubicin