<unk>  refers to a class of complex DNA rearrangement observed in the genomes of cancer cells. This phenomenon was first identified in prostate cancer by whole genome sequencing of prostate tumors.<unk>  causes genetic material from one or more chromosomes to become scrambled as multiple strands of DNA are broken and ligated to each other in a new configuration. In prostate cancer,<unk>  may cause multiple oncogenic events within a single cell cycle, providing a proliferative advantage to a (pre-)cancerous cell. Several oncogenic mutations in prostate cancer occur through<unk> , such as disruption of the tumor suppressor gene PTEN or creation of the TMPRSS2-ERG fusion gene.<unk>  was originally inferred by statistically analyzing the location of DNA breaks across the genome. Its prevalence across cancers is not known, because only a few types of tumors have been analyzed for<unk>  in the published literature. However, it was detected in the majority of 57 prostate tumors analyze and has been reported in non-small cell lung cancers, melanoma and head and neck squamous cell cancers. It has also been reported to generate the canonical gene fusion, EWSR1-FLI1 and EWSR1-ERG, in Ewing sarcoma. Along with chromothripsis, and break-fusion-bridge cycles,<unk>  is an example of chromoanagenesis, a catch-all term for events that generate complex structural chromosomal abnormalities.
Chromoplexy
Xanthochromia
Thrifty phenotype
Polychromasia
Anisochromia
Microphthalmia
Aniridia
Defocus aberration