<unk>  blocks cyclooxygenase (COX), the enzyme responsible for converting arachidonic acid into prostaglandin H2—the first step in the synthesis of prostaglandins, which are mediators of inflammation.<unk>  has been shown, especially at low therapeutic doses, to selectively inhibit COX-2 over COX-1.<unk>  concentrations in synovial fluid range from 40% to 50% of those in plasma. The free fraction in synovial fluid is 2.5 times higher than in plasma, due to the lower albumin content in synovial fluid as compared to plasma. The significance of this penetration is unknown, but it may account for the fact that it performs exceptionally well in treatment of arthritis in animal models.
Meloxicam
Ketoprofen
Lornoxicam
Aceclofenac
Loxoprofen
Fenoprofen
Celecoxib
Ibuprofen