In stage III disease, as classified by the Hurley's staging system, fistulae left undiscovered, undiagnosed, or untreated, can rarely lead to the development of squamous cell carcinoma in the anus or other affected areas. Other stage III chronic sequelae may also include anemia, multilocalized infections, amyloidosis, and arthropathy. Stage III complications have been known to lead to sepsis, but clinical data are still uncertain. Potential complications * Contractures and reduced mobility of the lower limbs and axillae due to fibrosis and scarring occur. Severe lymphedema may develop in the lower limbs. * Local and systemic infections (meningitis, bronchitis, pneumonia, etc.), are seen, which may even progress to sepsis. * Interstitial keratitis * Anal, rectal, or urethral fistulae * Normochromic or hypochromic anemia * People with<unk>  may be at increased risk for autoimmune disorders including ankylosing spondylitis, rheumatoid arthritis, and psoriatic arthritis. * Squamous cell carcinoma has been found on rare occasions in chronic<unk>  of the anogenital region. The mean time to the onset of this type of lesion is 10 years or more and the tumors are usually highly aggressive. * Tumors of the lung and oral cavity, and liver cancer * Hypoproteinemia and amyloidosis, which can lead to kidney failure and death * Seronegative and usually asymmetric arthropathy: pauciarticular arthritis, polyarthritis/polyarthralgia syndrome
Hidradenitis suppurativa
Acne
Folliculitis decalvans
Pilonidal disease
Streptococcal intertrigo
Acne conglobata
Helicobacter cellulitis
Keratolysis exfoliativa