Purpura fulminans lesions, once established, often progress within 24 to 48 hours to full-thickness skin necrosis or soft-tissue necrosis. Once purpura fulminans lesions progress to full-thickness skin necrosis, healing takes between 4–8 weeks and leaves large scars. Without treatment, necrotic soft tissue may become gangrenous, leading to loss of limbs. Purpura fulminans is often accompanied by micro-vascular thrombosis and haemorrhagic infarction in other tissues, such as the lungs, kidneys, central nervous system and adrenal glands, leading to multiple organ failure, and causes initial high mortality and long-term morbidity in survivors. Purpura fulminans may also lead to severe large vessel venous thrombosis if untreated in its early stages. Purpura fulminans secondary to severe infection is self-limiting. In cases of homozygous protein C deficiency, episodes of purpura fulminans and other thrombotic events are recurrent. Moreover, infant survival due to maintenance replacement therapy is often associated with mental retardation and/or visual impairment. For post-infection purpura fulminans, new lesions will occur while neutralising autoantibodies are present (1–2 weeks after presentation). A multi-disciplinary care team is usually required for rehabilitation after purpura fulminans.
symptom of Protein S deficiency
symptom of Vitamin K deficiency
symptom of Haemophilia
medical cause of Protein S deficiency
symptom of HELLP syndrome
symptom of Disseminated intravascular coagulation
symptom of Atransferrinemia
symptom of Babesiosis