Wyeth<unk>  20 mg The mechanism of action of<unk>  is to inhibit the final step in gastric acid production. In the gastric parietal cell of the stomach,<unk>  covalently binds to the H+/K+ ATP pump to inhibit gastric acid and basal acid secretion. The covalent binding prevents acid secretion for up to 24 hours and longer.<unk>  is metabolized in the liver by the cytochrome P450 system. Metabolism mainly consists of demethylation by CYP2C19 followed by sulfation. Another metabolic pathway is oxidation by CYP3A4.<unk>  metabolites are not thought to have any pharmacological significance. It is usually given with a prokinetic drug because of inactivity in the acidic environment of the stomach.<unk>  binds irreversibly to H+K+ATPase (proton pumps) to suppress the secretion of acid. Due to irreversible binding of the pumps, new pumps have to be made before acid production can be resumed. The drug's plasma half-life is about two hours. In veterinary medicine,<unk>  appears to be safe to use in several large animal species. The pharmacokinetics of<unk>  have been explored in several veterinary species, including calves, alpacas and foals with half lives reported as 2.81, 0.47, and 1.43 hours, respectively.<unk>  appears to be eliminated more quickly in goats when compared to calves, with goats having an elimination half-life of less than one hour.
Pantoprazole
Lansoprazole
Dexlansoprazole
Tenatoprazole
Rabeprazole
Omeprazole
Esomeprazole
Ranitidine