<unk>  (often abbreviated as<unk>  in literature) is a rare autosomal recessive genetic disorder characterized by short stature, predisposition to the development of cancer, and genomic instability.<unk>  is caused by mutations in the BLM gene which is a member of the RecQ DNA helicase family. Mutations in other members of this family, namely WRN and RECQL4, are associated with the clinical entities Werner syndrome and Rothmund–Thomson syndrome, respectively. More broadly,<unk>  is a member of a class of clinical entities that are characterized by chromosomal instability, genomic instability, or both and by cancer predisposition. Cells from a person with<unk>  exhibit a striking genomic instability that includes excessive crossovers between homologous chromosomes and sister chromatid exchanges (SCEs). The condition was discovered and first described by New York dermatologist Dr. David<unk>  in 1954.<unk>  has also appeared in the older literature as<unk> –Torre–Machacek syndrome.
Bloom syndrome
Plummer–Vinson syndrome
Schnitzler syndrome
Secretan's syndrome
Galloway Mowat syndrome
Mucus fishing syndrome
Naegeli–Franceschetti–Jadassohn syndrome
König's syndrome