<unk> , also called<unk>  syndrome or Gypsy type facial<unk>  syndrome, is a rare congenital syndrome. It is characterized by facial<unk>  (any type of cleft in the bones and tissues of the face, including a cleft lip and palate), a caudal appendage (a "human tail"), growth deficiency, intellectual and developmental disability, and abnormalities of the renal system (kidneys) and the male genitalia. Abnormalities of the heart, and other skeletal malformations may also be present. The syndrome was initially described by Georges<unk>  and associates in 1983. It is thought to be genetically related to Juberg-Hayward syndrome.<unk>  syndrome has also been considered as part of a spectrum of congenital genetic disorders associated with similar facial, urogenital and skeletal anomalies. Termed "3MC syndrome", this proposed spectrum includes<unk> , Michels and Mingarelli-Carnevale (OSA) syndromes. Mutations in the COLLEC11 and MASP1 genes are believed to be a cause of these syndromes. The incidence of<unk>  syndrome is unknown. The pattern of inheritance is autosomal recessive, which means a defective (mutated) gene associated with the syndrome is located on an autosome, and the syndrome occurs when two copies of this defective gene are inherited.
Malpuech facial clefting syndrome
Nager acrofacial dysostosis
Branchio-oculo-facial syndrome
Otofacial syndrome
Liber pantegni
Cleft Lip and Palate Association
Ablepharon macrostomia syndrome
Urofacial syndrome