In individuals with<unk><unk><unk>  disease who receive supplemental<unk> , carbon dioxide accumulation may occur through two main mechanisms: * Ventilation/perfusion matching: under-ventilated lung usually has a low<unk>  content which leads to localized vasoconstriction limiting blood flow to that lung tissue. Supplemental<unk>  abolishes this constriction, leading to poor ventilation/perfusion matching. This redistribution of blood to areas of the lung with poor ventilation reduces the amount of carbon dioxide eliminated from the system. * The Haldane effect: most carbon dioxide is carried by the blood as bicarbonate, and deoxygenated hemoglobin promotes the production of bicarbonate. Increasing the amount of<unk>  in the blood by administering supplemental<unk>  reduces the amount of deoxygenated hemoglobin, and thus reduces the capacity of blood to carry carbon dioxide.
Effect of oxygen on chronic obstructive pulmonary disease
Effects of high altitude on humans
Airway resistance
Central neurogenic hyperventilation
Pathophysiology of asthma
Pathophysiology of acute respiratory distress syndrome
Intermittent hypoxic training
Aspirin exacerbated respiratory disease