Pharmacodynamics +<unk>  Site Ki (nM) Species Ref (MK-801) 486–906 Rat σ1 118–481 Rat σ2 11,325–15,582 Rat 420>1,000 RatHuman 34,700 Rat 5,950 Rat 401–484 Rat ≥340 Rat >1,000 Rat 5-HT1A >1,000 Rat 5-HT1B/1D 54% at 1 μM Rat 5-HT2A >1,000 Rat α1 >1,000 Rat α2 >1,000 Rat β 35% at 1 μM Rat D2 >1,000 Rat H1 95% at 1 μM Rat 100% at 1 μM Rat 1,300–29,600(IC50) Rat Values are Ki (nM), unless otherwise noted. The smaller the value, the more strongly the drug binds to the site. The pharmacology of<unk>  is similar to that of dextromethorphan (DXM). However,<unk>  is much more potent as an NMDA receptor antagonist as well much less active as a serotonin reuptake inhibitor, but retains DXM's activity as a norepinephrine reuptake inhibitor. Pharmacokinetics<unk>  has a notably longer elimination half-life than its parent compound, and therefore has a tendency to accumulate in the blood after repeated administration of normally dosed dextromethorphan formulations. It is further converted to 3-HM or glucuronidated.
Dextrorphan
Procaine
Tetracaine
Dextromethorphan
Articaine
Proxymetacaine
Ropivacaine
Levobupivacaine