Formula structure of cholesterol<unk>  is typically due to a combination of environmental and genetic factors. Environmental factors include weight, diet, and stress. Loneliness is also a risk factor. Diet Diet has an effect on blood cholesterol, but the size of this effect varies between individuals. A diet high in sugar or saturated fats increases total cholesterol and LDL. Trans fats have been shown to reduce levels of HDL while increasing levels of LDL. A 2016 review found tentative evidence that dietary cholesterol is associated with higher blood cholesterol. As of 2018 there appears to be a modest positive, dose-related relationship between cholesterol intake and LDL cholesterol. Medical conditions and treatments A number of other conditions can also increase cholesterol levels including diabetes mellitus type 2, obesity, alcohol use, monoclonal gammopathy, dialysis therapy, nephrotic syndrome, hypothyroidism, Cushing’s syndrome and anorexia nervosa. Several medications and classes of medications may interfere with lipid metabolism: thiazide diuretics, ciclosporin, glucocorticoids, beta blockers, retinoic acid, antipsychotics), certain anticonvulsants and medications for HIV as well as interferons. Genetics Genetic contributions are usually due to the additive effects of multiple genes ("polygenic"), though occasionally may be due to a single gene defect such as in the case of familial<unk> . In familial<unk> , mutations may be present in the APOB gene (autosomal dominant), the autosomal recessive LDLRAP1 gene, autosomal dominant familial<unk>  <unk> HOLA3) variant of the PCSK9 gene, or the LDL receptor gene. Familial<unk>  affects about one in 250 individuals.
Hypercholesterolemia
Hyperlipidemia
Dyslipidemia
Hypertriglyceridemia
Hypolipoproteinemia
Prehypertension
Hypocholesterolemia
Dysglycemia