<unk>  <unk>  is a rare neurodegenerative disorder characterized by autonomic dysfunction, tremors, slow movement, muscle rigidity, and postural instability (collectively known as parkinsonism) and ataxia. This is caused by progressive degeneration of neurons in several parts of the brain including the basal ganglia, inferior olivary nucleus, and cerebellum. Many people affected by<unk>  experience dysfunction of the autonomic nervous<unk> , which commonly manifests as orthostatic hypotension, impotence, loss of sweating, dry mouth and urinary retention and incontinence. Palsy of the vocal cords is an important and sometimes initial clinical manifestation of the disorder. A modified form of the alpha-synuclein protein within affected neurons may cause<unk> . About 55% of<unk>  cases occur in men, with those affected first showing symptoms at the age of 50–60 years.<unk>  often presents with some of the same symptoms as Parkinson's disease. However, those with<unk>  generally show little response to the dopamine medications used to treat Parkinson's disease and only about 9% of<unk>  patients with tremor exhibit a true parkinsonian pill-rolling tremor.<unk>  is distinct from multisystem proteinopathy, a more common muscle-wasting syndrome.<unk>  is also different from<unk>  organ dysfunction syndrome, sometimes referred to as<unk>  organ failure, and from<unk>  organ<unk>  failures, an often-fatal complication of septic shock and other severe illnesses or injuries.
Multiple system atrophy
Pure autonomic failure
Progressive supranuclear palsy
Tropical ataxic neuropathy
Low pressure hydrocephalus
Spinal and bulbar muscular atrophy
Lewy body dementias
Amyotrophic lateral sclerosis