<unk>  (INN); abbreviated as<unk> ; original brand name CeeNU, now marketed as Gleostine) is an alkylating nitrosourea compound used in chemotherapy. It is closely related to semustine and is in the same family as streptozotocin. It is a highly lipid-soluble drug, thus it crosses the blood-brain barrier. This property makes it ideal for treating brain tumors, which is its primary use, although it is also used to treat Hodgkin lymphoma as a second-line option.<unk>  has a long time to nadir (the time when white blood cells reach their lowest number). Unlike carmustine,<unk>  is administered orally. It is a bifunctional alkylating agent, alkylates both DNA and RNA, has the ability to created interstrand cross-links (ICLs) in DNA. As with other nitrosoureas, it may also inhibit several key enzymatic processes by carbamoylation of amino acids in proteins.<unk>  is cell-cycle nonspecific. It has also been used in veterinary practice as a treatment for mast cell tumors in dogs.
Lomustine
Bendamustine
Carmustine
Ifosfamide
Mannomustine
Vincristine
Normustine
Busulfan