GRIs may be used in the clinical treatment of seizures, convulsions, or epilepsy as anticonvulsants/antiepileptics, anxiety disorders such as generalized anxiety disorder (GAD), social phobia (SP) also known as social anxiety disorder (SAD), and panic disorder (PD) as anxiolytics, insomnia as hypnotics, muscle tremors or spasms as muscle relaxants, and chronic pain as analgesics. They may also potentially be used as anesthetics in surgery.
GABA reuptake inhibitor
GABA analogue
Acetylcholinesterase inhibitor
Glycine reuptake inhibitor
Dopamine reuptake inhibitor
Norepinephrine reuptake inhibitor
Serotonin–dopamine reuptake inhibitor
Opioid antagonist