Diagnosis is made based on the combination of clinical features, characteristic morphologic and immunophenotypic changes of malignant cells. As clinical features and prognosis can be diverse, the disease is subtype-classified into four categories according to the Shimoyama classification: acute, lymphoma, chronic, smoldering. Normally, identification of at least 5 percent of tumor cells in peripheral blood and confirmation of human T-lymphotropic virus type-1 are sufficient for diagnosis of acute, chronic, and smoldering types. For the lymphoma type, histopathologic examination by biopsy of lymph nodes may be needed.
wiki page disambiguates of T-cell leukemia
symptom of Biphenotypic acute leukaemia
symptoms of Biphenotypic acute leukaemia
types of Acute lymphoblastic leukemia
symptom of Acute myeloid leukemia
medical cause of Neutropenia
symptom of Chronic lymphocytic leukemia
symptom of Chronic multifocal Langerhans cell histiocytosis