Early<unk>  lesions look similar to traumatic skin bleeds or<unk> c rashes, such as immune thrombocytopenic<unk>  or thrombotic thrombocytopenic<unk> ; however,<unk>  will rapidly progress to necrosis whereas other<unk> c rashes do not. In most cases, differential diagnoses may be distinguished from<unk>  by other clinical and laboratory findings. The initial appearance of<unk>  lesions is of well-demarcated erythaamatous lesions which progress rapidly to develop irregular central areas of blue-black haemorrhagic necrosis. Advancing areas of necrosis are often surrounded by a thin border of erythaema that fades into adjacent unaffected skin. Haemorrhage into the necrotic skin causes<unk>  lesions to become painful, dark and raised, sometimes with vesicle or blister (bulla) formation. The distribution of<unk>  lesions may be different according to the underlying pathogenesis.<unk>  in severe sepsis typically develops in the distal extremities and progresses proximally or appears as a generalised or diffuse rash affecting the whole body surface. In cases of severe inheritable protein C deficiency,<unk>  with disseminated intravascular coagulation manifests within a few hours or days after birth. Laboratory investigations=== The cardinal features of<unk>  investigations are the same as those of disseminated intravascular coagulation: prolonged plasma clotting times, thrombocytopenia, reduced plasma fibrinogen concentration, increased plasma fibrin-degradation products and occasionally microangiopathic haemolysis.
Purpura fulminans
Acne fulminans
Pyoderma gangrenosum
Leukemia cutis
Visceral larva migrans
Dandruff
Erythema multiforme minor
Ecthyma gangrenosum