Many drug-drug interactions with<unk>  are possible. QT prolongation<unk>  prolongs the QT interval, which can result in a severe interaction (torsade de pointes) when combined with other drugs that also prolong the QT interval. Patient-specific characteristics that increase the risk for a clinically-significant drug-drug interaction include: *increasing age *female sex *cardiac disease *electrolyte disturbances (low blood potassium) As a result, there are many QT-prolonging drugs that may interact with<unk> . These include medications such as methadone, amiodarone, citalopram, and fluconazole. Other medications may increase the risk for a low level of potassium in the blood, thereby indirectly increasing the risk for QT prolongation. For example, dexamethasone, hydrochlorothiazide, and theophylline can lower the level of potassium in the blood. CNS depression<unk>  can depress the central nervous system (CNS), which, in combination with other CNS depressants, may reduce a person's ability to perform tasks that require skills and attention. For example, clobazam, gabapentin, and levetiracetam all can depress the CNS. Hypotension The risk of hypotension (low blood pressure) is increased when<unk>  is combined with other drugs that lower blood pressure. These may include losartan, metoprolol, and pramipexole.
Lofexidine
Setiptiline
Pramocaine
Veratridine
Tocainide
Ivabradine
Nefopam
Procainamide