The symptoms of<unk>  vary from case to case. Major symptoms of<unk>  include abnormalities of the teeth and nails, such as dental dysplasia, and deformities of the head and face, which include a coarse prematurely-aged facial appearance with a prominent jaw. A skin abnormality known as acanthosis nigricans, which involves a discoloration (hyperpigmentation) and “velvety” thickening (hyperkeratosis) of the skin around skin fold regions of the neck, groin and under arms is also a common symptom. Symptoms will negatively impact the daily life of the patient, and will persist until treated. Minor symptoms may include an enlargement of the genitalia and precocious puberty and a deficiency or absence of fat tissue. Because individuals with<unk>  fail to use insulin properly, they may experience abnormally high blood sugar levels (hyperglycemia) after eating a meal, and abnormally low blood sugar levels (hypoglycemia) when not eating.
Rabson–Mendenhall syndrome
Wilson–Turner syndrome
Weismann-Netter–Stuhl syndrome
Rothmund–Thomson syndrome
Beckwith–Wiedemann syndrome
Schinzel–Giedion syndrome
Smith–Lemli–Opitz syndrome
Li–Fraumeni syndrome