<unk>  may present with local and whole-body symptoms: * Necrotic cutaneous<unk>  is the medical term for the skin only reaction of<unk> . It is characterized by a localized necrotic wound at the site of bite. The majority of Loxosceles bites result in minor skin irritation that heals in one week. Other lesions often need 6 to 8 weeks to heal, and can leave lasting scars. * Viscerocutaneous<unk>  refers to the combination of skin and other organ manifestations. This occurs infrequently after Loxosceles bites. Symptoms include low energy, nausea and vomiting, and fever. Destruction of blood cells (hemolytic anemia) may require transfusion and injure the kidney. Consumption of clotting factors (so-called disseminated intravascular coagulation "DIC") and destruction of platelets (thrombocytopenia) is reported most often in children. DIC may lead to dangerous bleeding. Occasionally, acute kidney failure may develop from myonecrosis and rhabdomyolysis, leading to coma. Loxosceles toxins Loxosceles venom has several toxins; the most important for necrotic arachnidism is the enzyme sphingomyelinase D. It is present in all recluse species to varying degrees and not all are equivalent. This toxin is present in only one other known spider genus (Sicarius). The toxin dissolves the structural components of the cell membrane generating ring forms that perhaps act as a trigger for cellular self-destruction. The area of destruction is limited to the presence of the enzyme which cannot reproduce.
Loxoscelism
Adiposogenital dystrophy
Phocomelia
Dolichostenomelia
Micrognathism
Rhizomelia
Sirenomelia
Microorchidism