*Only qualified, chemotherapy-certified nurses who have been trained in venipuncture and administration of medications with vesicant and irritant potential should be allowed to administer vesicants. *Choose a large, intact vein with good blood flow for the venipuncture and placement of the cannula. Do not choose inadvertently "dislodgeable" veins (e.g. dorsum of hand or vicinity of joints) if an alternative vein is available. *The digits, hands, and wrists should be avoided as intravenous sites for vesicant administration because of the close network of tendons and nerves that would be destroyed if an<unk> occurred. *Place the smallest gauge and shortest length catheter to accommodate the infusion. *Monitor the venipuncture site closely for evidence of infiltration and instructing patients to report any pain, discomfort, or tightness at the site. *The IV infusion should be freely flowing. The arm with the infusion should not begin to swell (oedema), "get red" (erythema), "get hot" (local temperature increase), and the patient should not notice any irritation or pain on the arm. If this occurs,<unk> management should be initiated. *The infusion should consist of a suitable carrier solution with an appropriately diluted medicinal/chemotherapy drug inside. *After the IV infusion has finished, flush the cannula with the appropriate fluid. *Finally, depending on clinical circumstances, central line access may be most appropriate for patients who require repeated administrations of vesicants and irritants.
Extravasation 
Intravasation
Lymphangiogenesis
Vasculogenesis
Vascular permeability
Vascular recruitment
Thromboregulation
Neovascularization