Features that may result from a high level of GH or expanding tumor include: * Headaches – often severe and prolonged * Soft tissue swelling visibly resulting in enlargement of the hands, feet, nose, lips, and ears, and a general thickening of the skin * Soft tissue swelling of internal organs, notably the heart with the attendant weakening of its muscularity, and the kidneys, also the vocal cords resulting in a characteristic thick, deep voice and slowing of speech * Generalized expansion of the skull at the fontanelle * Pronounced brow protrusion, often with ocular distension (frontal bossing) * Pronounced lower jaw protrusion (prognathism) with attendant macroglossia (enlargement of the tongue) and teeth spacing * Hypertrichosis, hyperpigmentation and hyperhidrosis may occur in these people. * Skin tags * Carpal tunnel syndrome Complications * Problems with bones and joints, including osteoarthritis, nerve compression syndrome due to bony overgrowth, and carpal tunnel syndrome * Hypertension * Diabetes mellitus * Cardiomyopathy, potentially leading to heart failure * Colorectal cancer * Sleep Apnea * Thyroid nodules and thyroid cancer * Hypogonadism * Compression of the optic chiasm by the growth of pituitary adenoma leading to visual problems
Acromegaly
Pachydermoperiostosis
Micromegaly
Hyperaldosteronism
Cinchonism
Pheochromocytoma
Hypoaldosteronism
Primary polydipsia