The diagnosis is based on involvement of less than 10% of the skin. It is known as TEN when more than 30% of the skin is involved and an intermediate form with 10 to 30% involvement. A positive Nikolsky's sign is helpful in the diagnosis of<unk>  and TEN. A skin biopsy is helpful, but not required, to establish a diagnosis of<unk>  and TEN. Pathology Micrograph showing full-thickness epidermal necrosis with a basket weave-like stratum corneum and separation of the dermis and epidermis, skin biopsy, H&E stain<unk> , like TEN and erythema multiforme, is characterized by confluent epidermal necrosis with minimal associated inflammation. The acuity is apparent from the (normal) basket weave-like pattern of the stratum corneum. Classification<unk>  <unk>  is a milder form of toxic epidermal necrolysis (TEN). These conditions were first recognised in 1922. A classification first published in 1993, that has been adopted as a consensus definition, identifies<unk> , toxic epidermal necrolysis, and<unk> /TEN overlap. All three are part of a spectrum of severe cutaneous reactions (SCAR) which affect skin and mucous membranes. The distinction between<unk> ,<unk> /TEN overlap, and TEN is based on the type of lesions and the amount of the body surface area with blisters and erosions. It is agreed that the most reliable method to classify EM,<unk> , and TEN is based on lesion morphology and extent of epidermal detachment. Blisters and erosions cover between 3% and 10% of the body in<unk> , 11–30% in<unk> /TEN overlap, and over 30% in TEN. The skin pattern most commonly associated with<unk>  is widespread, often joined or touching (confluent), papuric spots (macules) or flat small blisters or large blisters which may also join. These occur primarily on the torso.<unk> , TEN, and<unk> /TEN overlap can be mistaken for erythema multiforme. Erythema multiforme, which is also within the SCAR spectrum, differs in clinical pattern and etiology.
Stevens–Johnson syndrome
Staphylococcal scalded skin syndrome
Chickenpox
Streptococcal intertrigo
Skin condition
Johnson–Munson syndrome
Staphylococcal infection
Acute cutaneous lupus erythematosus