<unk>  is an epigenetic modification to the DNA packaging protein Histone H3. It is a mark that indicates the acetylation at the 56th lysine residue of the histone H3 protein. It is a covalent modification known as a mark of newly replicated chromatin as well as replication-independent histone replacement.<unk>  is important for chromatin remodeling and serves as a marker of new nucleosomes during DNA replication but its role in the cell cycle is debated. Lysine 56 is located at the amino-terminal αN-helix and close to the site where the DNA enters and exits the nucleosome. The studies on yeast might not apply to the mammals. Mammalian cells do not express HATs with high specificity to K56. Sirtuins can catalyze the removal of the acetyl group from K56<unk>  levels are elevated in cancer and pluripotent cells.TRIM66 reads unmodified H3R2K4 and<unk>  to respond to DNA damage.
H3K56ac
H4K8ac
H3K14ac
H3K9ac
H3K23ac
H4K12ac
H4K91ac
H4K5ac