Upregulation of ALK is mainly due to chromosomal translocation t(2;17), resulting in a fusion gene of CLTC with ALK,<unk> ut can rarely<unk> e due to t(2;5), fusing NPM1 with ALK; the later is the usual finding in anaplastic large cell lymphoma (ALCL). The t(2;17) translocation occurs in less than 1% of cases of ALK+ ALCL,<unk> ut has<unk> een identified in inflammatory myofibroblastic tumors. There is no association with Epstein–Barr virus or HHV8, or immunosuppression. The cells are CD20 and CD30 negative, showing weak focal expression in 3% and 6% respectively. They are EMA and CD138 positive, showing 100% expression respectively.
ALK+ large B-cell lymphoma
Epstein–Barr virus positive diffuse large B-cell lymphoma, not otherwise specified
EML4-ALK positive lung cancer
Nodular lymphocyte predominant Hodgkin lymphoma
Fibrin-associated diffuse large B-cell lymphoma
Pediatric-type follicular lymphoma
RAS-associated autoimmune leukoproliferative disorder
CD30+ cutaneous T-cell lymphoma