An individual who has consumed too much<unk>  typically displays one or more of these symptoms in a period of approximately four hours immediately following a suspected overdose: * Drowsiness * Mental confusion * Hypotension * Impaired motor functions * Impaired reflexes * Impaired coordination * Impaired balance * Dizziness * Coma Although not usually fatal when taken alone, a<unk>  overdose is considered a medical emergency and generally requires the immediate attention of medical personnel. The antidote for an overdose of<unk>  (or any other benzodiazepine) is flumazenil (Anexate). This drug is only used in cases with severe respiratory depression or cardiovascular complications. Because flumazenil is a short-acting drug, and the effects of<unk>  can last for days, several doses of flumazenil may be necessary. Artificial respiration and stabilization of cardiovascular functions may also be necessary. Though not routinely indicated, activated charcoal can be used for decontamination of the stomach following a<unk>  overdose. Emesis is contraindicated. Dialysis is minimally effective. Hypotension may be treated with levarterenol or metaraminol. The oral (lethal dose in 50% of the population) of<unk>  is 720 mg/kg in mice and 1240 mg/kg in rats. D. J. Greenblatt and colleagues reported in 1978 on two patients who had taken 500 and 2000 mg of<unk> , respectively, went into moderately deep comas, and were discharged within 48 hours without having experienced any important complications, in spite of having high concentrations of<unk>  and its metabolites desmethyldiazepam, oxazepam, and temazepam, according to samples taken in the hospital and as follow-up. Overdoses of<unk>  with alcohol, opiates or other depressants may be fatal.
Diazepam
Adinazolam
Ketazolam
Halazepam
Midazolam
Triazolam
Thiazepine
Quazepam