<unk>  is a chronic disease, which leads to visual function loss. This often results in difficulties performing daily tasks such as reading, recognizing faces, and driving, and ultimately has severe consequences on independence. Initially, patients often have good visual acuity if the<unk>  lesions are not involved in the central macular, or foveal, region of the retina. As such, a standard vision test may underrepresent the visual deficit experienced by patients who report challenges reading, driving or seeing in low light conditions. Reading speed is often initially unaffected due to foveal sparing, but worsens progressively as the area of<unk>  enlarges. As the disease progresses, vision-related quality-of-life declines markedly. While fluorescein angiography and optical coherence tomography are today well established for diagnosing and tracking progression in<unk>  more complex diagnostic assessments may be required in the context of clinical trials.
Geographic atrophy
Posterior cortical atrophy
Neurofibrillary tangle
Hippocampal sclerosis
Central chromatolysis
Amyloid plaques
Pellucid marginal degeneration
Superficial siderosis