In the human body,<unk>  is metabolized extracellularly by the enzyme diamine oxidase (DAO), and intracellularly by<unk>  N-methyltransferase (HNMT) and aldehyde oxidases (AOX1). In<unk> , the activity of DAO is limited, and<unk>  taken up by the diet and formed in the body is only partially metabolized. The consumption of<unk> -containing food (e.g., red wine or hard cheese) leads to a pseudoallergic reaction. It is unclear how<unk>  passes through the intestinal wall during absorption and enters the blood without coming into contact with the aldehyde oxidases expressed in intestinal cells and<unk>  N-methyltransferases.
Histamine intolerance
Pseudoallergy
Type I hypersensitivity
Allergy
Cholinergic urticaria
Type II hypersensitivity
Type IV hypersensitivity
NSAID hypersensitivity reactions