<unk>  (SADDAN), is a very rare genetic disorder. This disorder is one that affects bone growth and is characterized by skeletal, brain, and skin abnormalities. Those affected by the disorder are<unk> ly short in height and commonly possess shorter arms and legs. In addition, the bones of the legs are often bowed and the affected have smaller chests with shorter rib bones, along with curved collarbones. Other symptoms of the disorder include broad fingers and extra folds of skin on the arms and legs.<unk> ly, many individuals who suffer from the disorder show a higher level in<unk> s and disability. Seizures are also common due to structural abnormalities of the brain. Those affected may also suffer with apnea, the slowing or loss of breath for short periods of time. Many of the features of SADDAN are similar to those seen in other skeletal disorders, specifically<unk>  and thanatophoric dysplasia.<unk>  is a form of short-limbed dwarfism. This type of dwarfism is caused by the inability of the cartilage of the skeleton to ossify and turn to bone.<unk><unk>  is a skin condition in which areas of the skin is of a dark and velvety discoloration, often seen in the body folds and creases such as the armpits, groin, and neck. Within those affected by SADDAN,<unk><unk>  develops early on, usually in infancy or early childhood.
Severe achondroplasia with developmental delay and acanthosis nigricans
Hand and foot deformity with flat facies
Hypertension and brachydactyly syndrome
Mental retardation and microcephaly with pontine and cerebellar hypoplasia
Microphthalmia–dermal aplasia–sclerocornea syndrome
Abdominal musculature absent with microphthalmia and joint laxity
Terminal osseous dysplasia with pigmentary defects
Vesiculopustular eruption and leukemoid reaction in Down syndrome