Some signs and pathological changes in liver histology include: * Mallory's hyaline body – a condition where pre-keratin filaments accumulate in hepatocytes. This sign is not limited to<unk>  liver disease, but is often characteristic. * Ballooning degeneration – hepatocytes in the setting of<unk>  change often swell up with excess fat, water and protein; normally these proteins are exported into the bloodstream. Accompanied with ballooning, there is necrotic damage. The swelling is capable of blocking nearby biliary ducts, leading to diffuse cholestasis. * Inflammation – neutrophilic invasion is triggered by the necrotic changes and presence of cellular debris within the lobules. Ordinarily the amount of debris is removed by Kupffer cells, although in the setting of inflammation they become overloaded, allowing other white cells to spill into the parenchyma. These cells are particularly attracted to hepatocytes with Mallory bodies. If chronic liver disease is also present: * Fibrosis * Cirrhosis – a progressive and permanent type of fibrotic degeneration of liver tissue. Pathogenesis<unk>  liver injury Alcohol related liver disease
Alcoholic hepatitis
Viral hepatitis
Ischemic hepatitis
Autoimmune hepatitis
Alcoholic liver disease
Fatty liver disease
Non-alcoholic fatty liver disease
Idiopathic granulomatous hepatitis