<unk><unk>  was observed to occur in 14 of 50 families (28%) and in 14 of 152 individuals (9.2%) with Lynch<unk> , also known as HNPCC. The 2 major MMR proteins involved are hMLH1 and hMSH2. Approximately 70% of tumors associated with the MTS have microsatellite instability. While germline disruption of hMLH1 and hMSH2 is evenly distributed in HNPCC, disruption of hMSH2 is seen in greater than 90% of MTS patients. Gastrointestinal and genitourinary cancers are the most common internal malignancies. Colorectal cancer is the most common visceral neoplasm in<unk>  patients.
Muir–Torre syndrome
Galloway Mowat syndrome
Binder's syndrome
Gómez–López-Hernández syndrome
Zieve's syndrome
Mungan syndrome
Rosselli–Gulienetti syndrome
Löffler's syndrome