The<unk>  is the statistical relationship between the father's<unk>  at conception and biological effects on the child. Such effects can relate to birthweight, congenital disorders, life expectancy and psychological outcomes. A 2017 review found that while severe health effects are associated with higher<unk> <unk> , the total increase in problems caused by<unk> <unk>  is low. While<unk> <unk>  has increased since 1960–1970, this is not seen as a major public health concern. The genetic quality of sperm, as well as its volume and motility, all may decrease with<unk> , leading the population geneticist James F. Crow to claim that the "greatest mutational health hazard to the human genome is fertile older males". The<unk>  was first proposed implicitly by German physician Wilhelm Weinberg in 1912 and explicitly by British psychiatrist Lionel Penrose in 1955. DNA-based research started more recently, in 1998, in the context of paternity testing.
Paternal age effect
Fetal programming
Maternal effect
Replication error phenotype
Germline mosaicism
Human genetic enhancement
Germline mutation
Structural inheritance