The long-term forecast for the condition is poor. There is generally a slow progression of neuromuscular and bone changes over decades. Behavioural problems, or psychiatric disorders may also be present. The life expectancy in<unk>  is highly variable. Individuals with early onset severe disease often do not survive beyond childhood, whereas those with milder disorders may survive well into adult life. Independent living will be difficult, and patients with<unk>  may become socially isolated, and during the late stages of the disease, they may become wheelchair bound, as they can no longer walk unaided. This is likely to have a negative impact upon the quality of life of caregivers and family members.
Alpha-mannosidosis
Beta-mannosidosis
Galactosialidosis
Aspartylglucosaminuria
Essential fructosuria
Alkaptonuria
Hawkinsinuria
Glycosuria