The<unk> es are developmental syndromes caused by germline mutations (or in rare cases by somatic mosaicism) in genes that alter the Ras subfamily and mitogen-activated protein kinases that control signal transduction, including: * Capillary malformation-AV malformation syndrome * Autoimmune lymphoproliferative syndrome * Cardiofaciocutaneous syndrome * Hereditary gingival fibromatosis type 1 * Neurofibromatosis type 1 * Noonan syndrome * Costello syndrome, Noonan-like * Legius syndrome, Noonan-like * Noonan syndrome with multiple lentigines, formerly called LEOPARD syndrome, Noonan-like * SYNGAP1-related intellectual disability
RASopathy
Angiolathyrism
Atherosclerosis
Papillary stenosis
Arterial stiffness
MURCS association
Microcalcification
Hyper-CVAD