Norepinephrine degradation.<unk>  is shown in green boxes.<unk>  <unk> ; ) is one of several enzymes that degrade<unk> amines (neurotransmitters such as dopamine, epinephrine, and norepinephrine),<unk> estrogens, and various drugs and substances having a<unk>  structure. In humans,<unk>  protein is encoded by the<unk>  gene. Two isoforms of<unk>  are produced: the soluble short form (S-COMT) and the membrane bound long form (MB-COMT). As the regulation of<unk> amines is impaired in a number of medical conditions, several pharmaceutical drugs target<unk>  to alter its activity and therefore the availability of<unk> amines.<unk>  was first discovered by the biochemist Julius Axelrod in 1957.
Catechol-O-methyltransferase
Phenylalanine hydroxylase
Dopamine beta-hydroxylase
Tyrosine hydroxylase
Aromatic L-amino acid decarboxylase
Monoamine oxidase B
Monoamine oxidase
Monoamine oxidase A