<unk>  is a quinazoline derivative that competitively inhibits the ATP binding site of the EGFR receptor protein. EGFR drives malignant growth of cells when mutations occur within the tyrosine kinase domain of this protein. Such mutations cause unchecked cell proliferation, which inappropriately activates the anti-apoptotic Ras signaling pathway. By blocking the binding of ATP to EGFR,<unk>  prevents activity of the signal transduction cascade that initiates mitosis.
Icotinib
Tepotinib
Crizotinib
Nilotinib
Afatinib
Imatinib
Neratinib
Acalabrutinib