<unk>  differs from other phenothiazine neuroleptics in that aside from the usual profile of dopamine, α1-adrenergic, H1, and mACh receptor antagonism, it additionally produces potent blockade of several serotonin receptors, including 5-HT2A, 5-HT2C, and 5-HT7. These actions have been implicated in<unk> 's anxiolytic effects (5-HT2C) and lack of extrapyramidal side effects (5-HT2A), and despite being classified as a typical antipsychotic, it actually behaves like an atypical antipsychotic. Site Ki (nM) Species Ref H1 9.3 Guinea pig H2 351 Guinea pig H3 >10,000 Rat M1 13 Human M2 42 Human M3 32 Human M4 12 Human M5 35 Human 5-HT1A 517 Human 5-HT2A 1.5 Human 5-HT2C 12 Human 5-HT3 2,943 Human 5-HT7 22 Human D1 3.8 Human D2 5.8 Human D3 2.5 Human D4 5.3 Human α1 2.3 Rat α2 1320 Rat GABAA >10,000 Rat GABAB >10,000 Rat Values are Ki (nM). The smaller the value, the more strongly the drug binds to the site.
Cyamemazine
Indeloxazine
Rufinamide
Diethylcarbamazine
Viloxazine
Carbofuran
Ridinilazole
Hydrazoic acid