<unk>  is a genetic disease but since it is a rare disease the chances of inheriting the disease are not high. Since this is an autosomal recessive disease, two copies of the gene that contain the mutation must be present for one to show signs and symptoms of the disease. In order for one to be affected with the disease, both parents must contain the affected gene and pass it to their child. Even if a person is not affected by the disease, it is possible for them to be heterozygous, and still carry the affected gene and be able to pass it to their children; there would be a 25% chance that the child would actually be affected if both parents were carriers of the disease but did not actually display symptoms of the disease. Genetic MDM is most common on the Dalmatian island of Mljet (or<unk> , thought to be because of a founder effect. It is of autosomal recessive inheritance. It may be caused by a mutation on the SLURP1 gene, located on chromosome 8. The SLURP1 gene makes a protein called SLURP-1, and this protein is located in cells of the skin. The protein SLURP-1 helps with cell death regulation and help mediate inflammation that is occurring, this protein is important in keeping the skin cells at a level of homeostasis. A gene mutation would be caused by the chromosome 8qter, which codes for the SLURP1 gene, to be cut, thus causing a mutation in that gene, which would disrupt the way it controls the skin cells.
Meleda disease
Borna disease
Pogosta disease
Camisa disease
Minamata disease
Degos disease
Ontario Minamata disease
Haff disease