A deficiency of<unk>  causes accumulation of unesterified<unk>  in certain body tissues.<unk>  effluxes from cells as free<unk>  and is transported in HDL as esterified<unk> .<unk>  is the enzyme that esterifies the free<unk>  on HDL to<unk>  ester and allows the maturation of HDL.<unk>  deficiency does not allow for HDL maturation resulting in its rapid catabolism of circulating apolipoprotein A1 and apolipoprotein A2. The remaining form of HDL resembles nascent HDL. The<unk>  glycoprotein produces lysophosphatidylcholine and<unk>  ester and binds to lipoproteins after being secreted by the liver. Usually the enzyme produced is responsible for<unk>  ester formation and high density lipoprotein (HDL) metabolism, but in fish-eye disease the enzyme cannot esterify, or make the acid into an alkyl,<unk>  in HDL particles. However, there is only a partial deficiency because the enzyme remains active on the<unk>  particles in very low density lipoproteins (VLDL) and low density lipoproteins (LDL). The opaqueness of the eye is caused by the deposit of lipids onto the cornea.
Lecithin cholesterol acyltransferase deficiency
Lipoprotein lipase deficiency
2,4 Dienoyl-CoA reductase deficiency
Acyl-CoA oxidase deficiency
Carnitine-acylcarnitine translocase deficiency
Holocarboxylase synthetase deficiency
3-Hydroxy-3-methylglutaryl-CoA lyase deficiency
Mevalonate kinase deficiency