<unk>  is used to treat locally advanced or metastatic non-small-cell lung cancer (NSCLC), if the cancer cells are positive for the T790M mutation in the gene coding for EGFR or for activating EGFR mutations. The T790M mutation may be de novo or acquired following first-line treatment with other tyrosine kinase inhibitors (TKIs), such as gefitinib and afatinib. In the US, EGFR exon 19 deletions, exon 21 L858R mutations or the T790M status of the patient prior to treatment with<unk>  must be detected by a federally approved companion diagnostic test. The Food and Drug Administration (FDA) has approved FoundationOne CDx as one available companion diagnostic test for this purpose. In Europe and elsewhere, activating EGFR mutations or T790M mutations may be determined by a validated test. In people treated with<unk> , resistance usually develops within approximately 10 months. Resistance mediated by an exon 20 C797S mutation accounts for the majority of resistance cases. It can cause fetal harm, so should not be used in women who are pregnant, and women who take it should avoid becoming pregnant. Caution should be taken in people with a history of interstitial lung disease (ILD), as they were excluded from clinical trials, since the drug can cause severe ILD or pneumonitis. Caution should also be taken in people with a predisposition to long QT syndrome as the drug can provoke this.
Osimertinib
Mobocertinib
Lestaurtinib
Upadacitinib
Abrocitinib
Axitinib
Selpercatinib
Icotinib