<unk> , sold under the brand name Acupan among others, is a centrally acting, non-opioid painkilling medication, that is primarily used to treat moderate to severe pain.<unk>  acts in the brain and spinal cord to relieve pain via novel mechanisms: antinociceptive effects from triple monoamine reuptake inhibition, and antihyperalgesic activity through modulation of glutamatergic transmission.
Nefopam
Setiptiline
Lofexidine
Ivabradine
Fenoldopam
Verapamil
Alvimopan
Iofetamine 