<unk>  <unk> , also called somatomedin C, is a hormone similar in molecular structure to<unk>  which plays an important role in childhood growth, and has anabolic effects in adults.<unk>  is a protein that in humans is encoded by the<unk>  gene.<unk>  consists of 70 amino acids in a single chain with three intramolecular disulfide bridges.<unk>  has a molecular weight of 7,649 Daltons. In dogs, an ancient mutation in<unk>  is the primary cause of the toy phenotype.<unk>  is produced primarily by the liver. Production is stimulated by growth hormone (GH). Most of<unk>  is bound to one of 6 binding proteins (IGF-BP). IGFBP-1 is regulated by<unk> .<unk>  is produced throughout life; the highest rates of<unk>  production occur during the pubertal growth spurt. The lowest levels occur in infancy and old age. A synthetic analog of<unk> , mecasermin, is used in children for the treatment of growth failure.
Insulin-like growth factor 1
Keratinocyte growth factor
Calcitonin gene-related peptide
Growth hormone
Bryostatin
Orexin
Neurotrophic factors
Hemopoietic growth factor