Common side effects of the<unk> agonists and antagonists include symptoms of hypogonadism such as hot flashes, gynecomastia, fatigue, weight gain, fluid retention, erectile dysfunction and decreased libido. Long term therapy can result in metabolic abnormalities, weight gain, worsening of diabetes and osteoporosis. Rare, but potentially serious adverse events include transient worsening of prostate cancer due to surge in testosterone with initial injection of<unk> agonists and pituitary apoplexy in patients with pituitary adenoma. Single instances of clinically apparent liver injury have been reported with some<unk> agonists (histrelin, goserelin), but the reports were not very convincing. There is no evidence to indicate that there is cross sensitivity to liver injury among the various<unk> analogues despite their similarity in structure. There is also a report that<unk> agonists used in the treatment of advanced prostate cancer may increase the risk of heart problems by 30%.
Gonadotropin-releasing hormone agonist
Gonadotropin-releasing hormone antagonist
Gonadotropin-releasing hormone modulator
Prolactin modulator
Antiandrogen
Thyroid blocker
17α-Alkylated anabolic steroid
Steroidal antiandrogen