<unk>  (DLCs) are a group of chemical<unk>  that are persistent organic pollutants (POPs) in the environment. They are mostly by-products of burning or various industrial processes - or, in case of dioxin-like PCBs and PBBs, unwanted minor components of intentionally produced mixtures. Some of them are highly toxic, but the toxicity among them varies 30,000-fold. They are grouped together because their mechanism of action is the same. They activate the aryl hydrocarbon receptor (AH receptor), albeit with very different binding affinities, leading to high differences in toxicity and other effects. They include: * Polychlorinated dibenzo-p-dioxins (PCDDs), or simply dioxins. PCDDs are derivatives of dibenzo-p-dioxin. There are 75 PCDD congeners, differing in the number and location of chlorine atoms, and 7 of them are specifically toxic, the most toxic being 2,3,7,8-tetrachlorodibenzodioxin (TCDD). * Polychlorinated dibenzofurans (PCDFs), or furans. PCDFs are derivatives of dibenzofuran. There are 135 isomers; 10 have dioxin-like properties. * Polychlorinated biphenyls (PCBs), derived from biphenyl, of which 12 are "dioxin-like". Under certain conditions PCBs may form dibenzofurans through partial oxidation. * Polybrominated analogs of the above classes may have similar effects. * "Dioxin" can also refer to 1,4-dioxin or p-dioxin, the basic chemical unit of the more complex dioxins. This simple<unk> is not persistent and has no PCDD-like toxicity. File:PCDD general structure.Polychlorinated dibenzo-p-dioxins File:PCDF general structure.Polychlorinated dibenzofurans File:PCB structure general.Polychlorinated biphenyls File:1,4-Dioxin.1,4-dioxin Dioxins have different toxicity depending on the number and position of the chlorine atoms. Because dioxins refer to such a broad class of<unk>  that vary widely in toxicity, the concept of toxic equivalency factor (TEF) has been developed to facilitate risk assessment and regulatory control. TEFs exist for seven congeners of dioxins, ten furans and twelve PCBs. The reference congener is the most toxic dioxin TCDD which per definition has a TEF of one. In essence, multiplying the amount of a particular congener with its TEF produces the amount toxicologically equivalent to TCDD, and after this conversion all dioxin-like congeners can be summed up, and the resulting toxicity equivalent quantity (TEQ) gives an approximation of toxicity of the mixture measured as TCDD. Dioxins are virtually insoluble in water but have a relatively high solubility in lipids. Therefore, they tend to associate with organic matter such as plankton, plant leaves, and animal fat. In addition, they tend to be adsorbed to inorganic particles, such as ash and soil. Dioxins are extremely stable and consequently tend to accumulate in the food chain. They are eliminated very slowly in animals, e.g. TCDD has a half-life of 7 to 9 years in humans. Incidents of contamination with PCBs are often reported as dioxin contamination incidents since these are of most public and regulatory concern.
Dioxins and dioxin-like compounds
Polychlorinated naphthalene
Polychlorinated dibenzodioxins
Organobromine compound
Organochlorine compound
Polycyclic aromatic hydrocarbon
Loline alkaloid
Polychlorinated dibenzofurans