Gut<unk>  has been linked to the “pathogenesis of both intestinal and extra-intestinal disorders." Intestinal disorders include IBD, IBS, and coeliac disease, and extra-intestinal conditions include allergies, asthma, metabolic syndrome, cardiovascular disease, and obesity.<unk>  has played a role in autoimmune diseases, allergies, and metabolic disorders. Gut<unk>  can also be a factor in neurodegenerative and cerebrovascular diseases due to the link between age-related<unk>  and neurological decline by inflammation being the common factor for a wide variety of age-related pathologies. By correcting the<unk>  in elderly patients, it may be possible to prevent the development of neurodegenerative diseases.<unk>  may contribute to the cause or development of neurological conditions, including “autism, pain, depression, anxiety, and stroke.”<unk>  contributing to neurological conditions is due to interactions with the gut-brain axis allowing the gut microbiome to influence neural development, cognition, and behavior. There has also been evidence that the gut microbiota composition can be altered due to changes in behavior, and changing the microbiome can also cause depressive-like behaviors. When this balance is disturbed, these colonies exhibit a decreased ability to check each other's growth, which can then lead to overgrowth of one or more of the disturbed colonies which may further damage some of the other smaller beneficial ones in a vicious cycle. As more beneficial colonies are damaged, making the imbalance more pronounced, more overgrowth issues occur because the damaged colonies are less able to check the growth of the overgrowing ones. If this goes unchecked long enough, a pervasive and chronic imbalance between colonies will set in, which ultimately minimizes the beneficial nature of these colonies as a whole. Microbial colonies also excrete many different types of waste byproducts. Using different waste removal mechanisms, under normal circumstances the body effectively manages these byproducts with little or no trouble. Unfortunately, oversized and inappropriately large colonies, due to their increased numbers, excrete increased amounts of these byproducts. As the amount of microbial byproducts increases, the higher waste byproducts levels can overburden the body's waste removal mechanisms. It is the combination of these two negative outcomes that causes many of the negative health symptoms observed when<unk>  is present. A human’s microbiome can change because of inflammatory processes, such as cell-mediated inflammation and host-mediated inflammation, or a ‘driver’ bacteria causing/aggravating inflammation. This change allows the microbial community to become more susceptible to pathogens. Once the pathogens are established successfully, they contribute to<unk>  and produce genotoxins and other potential cancer-causing microbial metabolites. The evolution of pathogens is another possible effect of<unk> , contributing to a potential increase in cancer risk. Gut<unk>  can affect the cardiovascular system “via signaling molecules and bioactive metabolites. This could cause diseases through neuro-entero-endocrine hormones that can lead to heart failure and other conditions such as chronic kidney disease, hypertension, obesity, and diabetes.
Dysbiosis
Steatosis
Degranulation
Flatulence
Necrobiosis
Virulence
Scalding
Acid erosion