<unk>  is a prodrug which is activated by the enzyme ethA, a mono-oxygenase in Mycobacterium tuberculosis, and then binds NAD+ to form an adduct which inhibits InhA in the same way as isoniazid. The mechanism of action is thought to be through disruption of mycolic acid. Expression of the ethA gene is controlled by ethR, a transcriptional repressor. It is thought that improving ethA expression will increase the efficacy of<unk>  and prompting interest by drug developers in EthR inhibitors as a co-drug.
Ethionamide
Dimethyllysergamide
Triparanol
Phenoxyethanol
Chloroxylenol
Iodixanol
Flonicamid
Phenethylamine