MDA is a substituted methylenedioxylated phenethylamine and amphetamine derivative. In relation to other phenethylamines and amphetamines, it is the<unk> ,4-methylenedioxy, α-methyl derivative of β-phenylethylamine, the<unk> ,4-methylenedioxy derivative of amphetamine, and the N-desmethyl derivative of MDMA. Synonyms In addition to<unk> , MDA is also known by other chemical synonyms such as the following: * α-Methyl-3,4-methylenedioxy-β-phenylethylamine * 1-<unk> ,4-Methylenedioxyphenyl)-2-propanamine * 1-(1,3-Benzodioxol-5-yl)-2-propanamine Synthesis MDA is typically synthesized from essential oils such as safrole or piperonal. Common approaches from these precursors include: * Reaction of safrole's alkene functional group with a halogen containing mineral acid followed by amine alkylation. Synthesis of MDA and related analogs from safrole * Wacker oxidation of safrole to yield<unk> ,4-methylenedioxyphenylpropan-2-one (MDP2P) followed by reductive amination or via reduction of its oxime. * Henry reaction of piperonal with nitroethane followed by nitro compound reduction. *Darzens reaction on heliotropin was also done by J. Elks, et al. This gives MDP2P, which was then subjected to a Leuckart reaction. Detection in body fluids MDA may be quantitated in blood, plasma or urine to monitor for use, confirm a diagnosis of poisoning or assist in the forensic investigation of a traffic or other criminal violation or a sudden death. Some drug abuse screening programs rely on hair, saliva, or sweat as specimens. Most commercial amphetamine immunoassay screening tests cross-react significantly with MDA and major metabolites of MDMA, but chromatographic techniques can easily distinguish and separately measure each of these substances. The concentrations of MDA in the blood or urine of a person who has taken only MDMA are, in general, less than 10% those of the parent drug.enedioxymethamphetamine after controlled oral administration to young adults. Ther. Drug Monit.<unk> 0:<unk> 20–332, 2008. Derivatives MDA constitutes part of the core structure of the β-adrenergic receptor agonist protokylol.
3,4-Methylenedioxyamphetamine
3,4-Methylenedioxy-N-ethylamphetamine
Methamphetamine
Cannabis
Cannabis 
Benzphetamine
Benzyl alcohol
Amphetamine