Holoprosencephaly is typically diagnosed during fetal development when there are abnormalities found on fetal brain imaging, however it can also be diagnosed after birth. The Protocol for<unk>  includes neuroimaging (Ultrasound or fetal MRI prior to birth or Ultrasound, MRI or CT post birth), syndrome evaluation, cytogenetics, molecular testing, and genetic counseling. There are four classifications of holoprosencephaly as well as a “microform". These classifications can be distinguished by their anatomical differences. * Alobar holoprosencephaly * Small single forebrain ventricle * No interhemispheric division * Absence of olfactory bulbs and tracts * Absence of corpus callosum * Non separation of deep gray nuclei * Semilobar holoprosencephaly * Rudimentary cerebral lobes * Incomplete interhemispheric division * Absence or hypoplasia of olfactory bulbs and tracts * Absence of corpus callosum * Varying non separation of deep gray nuclei * Lobar holoprosencephaly * Fully-developed cerebral lobes * Distinct interhemispheric division * Midline continuous frontal neocortex * Absent, hypoplasic or normal corpus callosum * Separation of deep gray nuclei * Syntelencephaly, or middle interhemispheric variant of holoprosencephaly (MIHV) * Failure of separation of the posterior frontal and parietal lobes * Callosal genu and splenium normally formed * Absence of corpus callosum * Hypothalamus and lentiform nuclei normally separated * Heterotopic gray matter * Microform * Subtle defects of corpus callosum * Subtle midline brain defects
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