The progression of symptoms varies widely between each case of<unk> ; the onset of symptoms may be gradual, with progression of the disease spanning multiple years or decades. Alternatively, symptoms may progress rapidly.<unk>  has shown strong age-dependent penetrance, afflicting older premutation carriers with greater prevalence. Male carriers, age 50 and above have a 30% chance of developing<unk> , while male carriers, age 75 and above, have a 75% chance of developing the disorder. While initially described as affecting male carriers, female carriers of the FMR1 gene mutation have also been found to develop<unk> . However, due to<unk> -inactivation, female carriers are much less likely to develop dementia or classic<unk>  and<unk> , instead demonstrating symptoms such as fibromyalgia, thyroid disease, hypertension, and seizures.
Fragile X-associated tremor/ataxia syndrome
X-linked dystonia parkinsonism
Huntington's disease-like syndrome
Fragile X syndrome
Rett syndrome
Dravet syndrome
Trichothiodystrophy
Parkinson-plus syndrome