<unk> , sold under the brand name Adakveo & Ryverna both by Novartis, is a monoclonal antibody medication that binds to P-selectin. It is a drug used to reduce the frequency of vaso-occlusive crisis in people aged 16 years and older who have sickle cell anemia. Vaso-occlusive crisis is a common and painful complication of sickle cell disease that occurs when blood circulation is obstructed by sickled red blood cells (red cells are usually round and flexible, but sometimes many red cells in a person with sickle cell anemia will become rigid and crescent-shaped due to polymerization of hemoglobin). The result of the Phase II SUSTAIN clinical trial was published in December 2016, and in November 2019,<unk> -tmca was approved in the United States. The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication.
Crizanlizumab
Brolucizumab
Tildrakizumab
Risankizumab
Reslizumab
Mogamulizumab
Inebilizumab
Etaracizumab