<unk>  in combination with Coxsackievirus infection can lead to Keshan disease, which is potentially fatal.<unk>  also contributes (along with iodine deficiency) to Kashin-Beck disease. The primary symptom of Keshan disease is myocardial necrosis, leading to weakening of the heart. Kashin-Beck disease results in atrophy, degeneration and necrosis of cartilage tissue. Keshan disease also makes the body more susceptible to illness caused by other nutritional, biochemical, or infectious diseases.<unk>  is also necessary for the conversion of the thyroid hormone thyroxine (T4) into its more active counterpart triiodothyronine (T3), and as such a deficiency can cause symptoms of hypothyroidism, including extreme fatigue, mental slowing, goiter, cretinism, and recurrent miscarriage.
Selenium deficiency
Fluorine deficiency
Chromium deficiency
Boron deficiency 
Biotin deficiency
Copper deficiency
Thiamine deficiency
Zinc deficiency