Location of the gallbladder Most people with gallstones do not have symptoms. However, when a gallstone temporarily lodges in the cystic duct, they experience biliary colic. Biliary colic is abdominal pain in the right upper quadrant or epigastric region. It is episodic, occurring after eating greasy or fatty foods, and leads to nausea and/or vomiting. People who suffer from<unk>  most commonly have symptoms of biliary colic before developing<unk> . The pain becomes severe and constant in<unk> . Nausea is common and vomiting occurs in 75% of people with<unk> . In addition to abdominal pain, right shoulder pain can be present. On physical examination, an inflamed gallbladder is almost always tender to the touch and palpable (~25-50% of cases) in the midclavicular right lower rib margin. Additionally, a fever is common. A gallbladder with<unk>  is almost always tender to touch. Because of the inflammation, its size can be felt from the outside of the body in 25–50% of people with<unk> . Pain with deep inspiration leading to termination of the breath while pressing on the right upper quadrant of the abdomen usually causes severe pain (Murphy's sign). Yellowing of the skin (jaundice) may occur but is often mild. Severe jaundice suggests another cause of symptoms such as choledocholithiasis. People who are old, have diabetes, chronic illness, or who are immunocompromised may have vague symptoms that may not include fever or localized tenderness. Complications A number of complications may occur from<unk>  if not detected early or properly treated. Signs of complications include high fever, shock and jaundice. Complications include the following: * Gangrene * Gallbladder rupture * Empyema * Fistula formation and gallstone ileus * Rokitansky-Aschoff sinuses Gangrene and gallbladder rupture<unk>  causes the gallbladder to become distended and firm. Distension can lead to decreased blood flow to the gallbladder, causing tissue death and eventually gangrene. Once tissue has died, the gallbladder is at greatly increased risk of rupture (perforation), which can cause sharp pain. Rupture can also occur in cases of chronic<unk> . Rupture is a rare but serious complication that leads to abscess formation or peritonitis. Massive rupture of the gallbladder has a mortality rate of 30%. Empyema Untreated<unk>  can lead to worsened inflammation and infected bile that can lead to a collection of pus inside the gallbladder, also known as empyema. The symptoms of empyema are similar to uncomplicated<unk>  but greater severity: high fever, severe abdominal pain, more severely elevated white blood count. Fistula formation and gallstone ileus The inflammation of<unk>  can lead to adhesions between the gallbladder and other parts of the gastrointestinal tract, most commonly the duodenum. These adhesions can lead to the formation of direct connections between the gallbladder and gastrointestinal tract, called fistulas. With these direct connections, gallstones can pass from the gallbladder to the intestines. Gallstones can get trapped in the gastrointestinal tract, most commonly at the connection between the small and large intestines (ileocecal valve). When a gallstone gets trapped, it can lead to an intestinal obstruction, called gallstone ileus, leading to abdominal pain, vomiting, constipation, and abdominal distension.
Cholecystitis
Hepatitis
Cholangitis 
Angina
Biliary colic
Peptic ulcer disease
Pancreatitis
Pneumonia