The cause is a genetic mutation in the MAPKinase pathway that occurs during early development. The origin is a dendritic<unk> , although previously thought to be a histiocyte, a term still used. The mutations causes white blood<unk> s (lymphocytes, macrophages, and eosinophils) to move towards dendritic<unk> s, resulting in damage in any organ except the heart and kidneys. The disease was once thought to be a lipid storage disease as the lesions have a high cholesterol content, but the blood cholesterol is usually normal. Some sources such as the National Cancer Institute describe it as a type of cancer, while other sources specifically state it is not a type of cancer.
Chronic multifocal Langerhans cell histiocytosis
Progressive nodular histiocytoma
Progressive nodular histiocytosis
Thymoma-associated multiorgan autoimmunity
Skin manifestations of sarcoidosis
Acrokeratoelastoidosis of Costa
AIDS-related lymphoma
Inflammatory myofibroblastic tumour