The complicated role<unk>  plays in immune system regulation presents an opportunity for<unk>  interactions to go rogue in various diseases. The up-regulation of<unk>  has been linked to various autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus and sepsis (which may partly be due to over-active T-cells), and<unk>  has also been shown to help spread of HIV infection in the body.<unk>  is also linked to various cancers, though some experience<unk>  induced tolerance via possible regulatory T-cell interaction. Others experience inhibited growth and metastasis-related to<unk>  up-regulation, further exemplifies the complicated role<unk>  plays. The triggering of Natural Killer cell-mediated death via<unk>  interactions has been explored as possible cancer immunotherapy by inducing<unk>  expression on tumor cells.
CD80
CD74
CD86
CD23
CD137
CD22
CD4
CD44