Facial features (A), left hand and feet showing broad thumb and big toes (B, C) and X-ray of both hands showing short broad thumbs (D). (Limb Malformations & Skeletal Dysplasia)<unk>  presents itself from birth, and is usually hallmarked by delayed physical and cognitive growth. Typical features of the disorder include: * Broad thumbs and broad first toes and clinodactyly of the 5th finger * Mental disability * Small height, low bone growth, small head * Cryptorchidism in males * Unusual facies involving the eyes, nose, and palate * Anesthesia may be dangerous in these patients: "According to the medical literature, in some cases, individuals with<unk>  may have complications (e.g., respiratory distress and/or irregular heart beats cardiac arrythmias) associated with a certain muscle relaxant (succinylcholine) and certain anesthesia. Any situations requiring the administration of anesthesia or succinylcholine (e.g., surgical procedures) should be closely monitored by skilled professionals (Anesthesiologists)." Primary literature suggests the children may have a higher rate of cardiac physical and conduction abnormalities which may cause unexpected results with cardioactive medications. A further editorial reply in the British Journal of Anaesthesia discusses changes in the face and airway structure making it more difficult to secure the airway under anaesthesia, however, complications appeared in a minority of cases, and routine methods of airway control in the operating room appears to be successful. They recommended close individual evaluation of<unk><unk>  patients for anaesthetic plans. A 2009 study found that children with RTS were more likely to be overweight and to have a short attention span, motor stereotypies, and poor coordination. The study hypothesized that the identified CREBBP gene impaired motor skills learning. Other research has shown a link with long-term memory (LTM) deficit. It is diagnosed when a heterozygous pathogenic variant of the CREBBP gene is identified in the individual. It exhibits an autosomal dominant inheritance pattern, but some documented cases show heterozygous individuals exhibiting germline mosaicism. This condition affects men and women equally, and is often misdiagnosed with other diseases or disabilities that result in delayed mental development.
Rubinstein–Taybi syndrome
Dubin–Johnson syndrome
Vanishing bile duct syndrome
Crigler–Najjar syndrome
Wilson–Mikity syndrome
Frank–Ter Haar syndrome
Shwachman–Diamond syndrome
Gaucher's disease