Chemistry and mechanism of action Contrast CT of a patient with brain metastases from breast cancer, before (left) and after (right) injection of an iodine-containing contrast agent<unk>  is an iodine-containing, water-soluble radiocontrast agent. The iodine atoms readily absorb X-rays, resulting in a higher contrast of X-ray images. It has a low osmolality, meaning that the solution has a relatively low concentration of molecules; this is usually associated with fewer adverse effects than high-osmolality contrast agents. A phase III clinical trial concluded that<unk>  produces images of a similarly high quality as iohexol, and that it is equally well tolerated by patients. Pharmacokinetics After intravenous injection,<unk>  is distributed in the extracellular space. Its binding to plasma proteins is very low. The substance is not metabolized, but excreted in unchanged form via the kidneys, exclusively by glomerular filtration. Only 2% are excreted in the faeces. The biological half-life is two hours.
Iopentol
Methohexital
Metharbital
Etomidate
Fenpentadiol
Dextromoramide
Dianethole
Perineurium