The cause of PMR is not well understood. The pain and stiffness result from the activity of inflammatory<unk> s and proteins that are normally a part of the body's disease-fighting immune system, and the inflammatory activity seems to be concentrated in tissues surrounding the affected joints. During this disorder, the white blood<unk> s in the body attack the lining of the joints, causing inflammation. Inherited factors also play a role in the probability that an individual will develop PMR. Several theories have included viral stimulation of the immune system in genetically susceptible individuals. Infectious diseases may be a contributing factor. This would be expected with sudden onset of symptoms, for example. In addition, new cases often appear in cycles in the general population, implying a viral connection. Studies are inconclusive, but several somewhat common viruses were identified as possible triggers for PMR. The viruses thought to be involved include the adenovirus, which causes respiratory infections; the human parvovirus B19, an infection that affects children; and the human parainfluenza virus. Some sufferers attribute the onset of PMR to stress. Persons having the HLA-DR4 type of human leucocyte antigen appear to have a higher risk of PMR.
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symptom of Giant cell arteritis
treatment of Giant cell arteritis
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complications of Vertebral artery dissection
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complications of Neuroleptic malignant syndrome