Due to the ongoing research involving radiofluorinated molecules and their various uses, the demand for suitable syntheses has increased over the years. In order for synthetic methods to be considered viable, the process must be rapid and efficient as well as compatible with the forms of 18F with are available. In many cases, the synthesis must also be capable of regio- and stereo-specificity. Positron Emission of Fluorine-18. Typically, radiofluorinated products are synthesized using nucleophilic or electrophilic substitution processes. One classical method for<unk>  is the Balz-Schiemann reaction, or a modified Balz-Schiemann reaction with 18F F−. Electrophilic substitution reactions typically make use of 18F F2 as a precursor which can then be added to an array of molecules such as alkenes, aromatic rings, and carbanions 21. However, methods utilizing 18F F2 are at a disadvantage due to the loss 50% of the input activity in the form of 18F F−. To facilitate these procedures the reaction may also be carried out within a microfluidic chamber.
Radiofluorination
Salicylate testing
Sweat test
Transillumination
Gallocyanin stain
Mesomark assay
Suction
Suction 