X-linked severe combined immunodeficiency X-linked severe combined immunodeficiency is caused by mutations in the IL2RG gene. More than 200 different mutations in the IL2RG gene have been identified in people with X-linked severe combined immunodeficiency (SCID). Most of these mutations involve<unk> ges in one or a few nucleotides (DNA building blocks) in the gene. These<unk> ges lead to the production of a nonfunctional version of the<unk>  protein or no production of protein. Without the<unk> , important chemical signals are not relayed to the nucleus and lymphocytes cannot develop normally. A lack of functional mature lymphocytes disrupts the immune system's ability to protect the body from infection. Sufferers have no functional immunity and can die within months after birth without successful bone marrow transplantation or alternatively, isolation from exposure to pathogens. Without important developmental signals from IL-7 and IL-15, T-cell and NK cell populations respectively fail to develop. Experiments in animal models have shown X-SCID to occur similarly in dogs, but not in mice. Schizophrenia Alterations in the immune response are involved in pathogenesis of many neuropsychiatric disorders including schizophrenia. Distinct gene variants of a number of pro-inflammatory and chemotactic cytokines together with their receptors associate with this disorder. IL2RG represents an important signaling<unk> ent of many interleukin receptors and so far, no data on the functional state of this receptor in schizophrenia have been reported. Over-expression of the IL2RG gene may be implicated in altered immune response in schizophrenia and contribute to the pathogenesis of this disorder.
Common gamma chain
Fragment crystallizable region
Duffy antigen system
Major histocompatibility complex, class II, DQ alpha 1
Fc receptor
T independent antigen 
Complement component 4
Complement component 3