The condition results from infection, injury (accident, surgery), hypoperfusion and hypermetabolism. The primary cause triggers an uncontrolled inflammatory response.<unk>  is the most common cause of multiple organ dysfunction syndrome and may result in septic shock. In the absence of infection, a<unk> -like disorder is termed systemic inflammatory response syndrome (SIRS). Both SIRS and<unk>  could ultimately progress to multiple organ dysfunction syndrome. However, in one-third of the patients no primary focus can be found. Multiple organ dysfunction syndrome is well established as the final stage of a continuum: SIRS + infection File:U+2192.svg<unk>  File:U+2192.svg severe<unk>  File:U+2192.svg Multiple organ dysfunction syndrome. Currently, investigators are looking into genetic targets for possible gene therapy to prevent the progression to multiple organ dysfunction syndrome. Some authors have conjectured that the inactivation of the transcription factors NF-κB and AP-1 would be appropriate targets in preventing<unk>  and SIRS. These two genes are pro-inflammatory. However, they are essential components of a normal healthy immune response, so there is risk of increasing vulnerability to infection, which can also cause clinical deterioration.
complications of Sepsis
complications of Typhus
complications of Fever
medical cause of Multiple organ dysfunction syndrome
medical cause of Cardiogenic shock
complications of Peritonitis
complications of Coma
complications of Lemierre's syndrome