Part of the<unk> ' doctrine, from EPA Guidelines for the Health Risk Assessment of Chemical Mixtures<unk>  is a 20th-century para-legal concept used in the chemical industry for toxicological studies. The term was first employed in a restricted sense to assess surrogacy of chemical mixtures by the EPA, and has descended from there into the scientific argot. The concept is somewhat nebulous, and statistics are involved. A group of America researchers in 2018 posed themselves the question how similar must a product be in order to be well-represented by the tested reference sample? Because the concept was derived from the EPA, chemical<unk>  and biological<unk>  are equally important. The concept is employed "so that safety data from the tested reference can be applied to untested materials," because "when toxicity data are not available for a chemical mixture of concern, US EPA guidelines allow risk assessment to be based on data for a surrogate mixture considered<unk> ly similar” in terms of chemical composition and component proportions."
Sufficient similarity
Acute to chronic ratio
Concept creep
Cryptocurrency
Orgastic potency
Tissue selectivity
Specific dynamic action
Form constant