Mechanism of action It is a synthetic prostaglandin analog (or more specifically, an analog of prostaglandin F2α) that works by increasing the outflow of aqueous fluid from the eyes. Like other analogs of prostaglandin F2α such as tafluprost and latanoprost,<unk>  is an ester prodrug of the free acid, which acts as an agonist at the prostaglandin F receptor, increasing outflow of aqueous fluid from the eye and thus lowering intraocular pressure. Pharmacokinetics<unk>  is absorbed through the cornea, where it is hydrolysed to the free<unk>  acid. Highest concentrations of the acid in the eye are reached one to two hours after application, and its half-life in the aqueous fluid is 1.5 hours. Once it reaches the bloodstream, it is quickly metabolised, so that concentrations in the system do not exceed 25 pg/ml (compared to 20 ng/ml in the eye, which is higher by nearly a factor of 1000). Metabolites are formed by beta oxidation of the acidic chain (compare Tafluprost#Pharmacokinetics), oxidation of the OH-group in the other side chain, and reduction of the double bond next to this OH-group.<unk>  acid and its metabolites are mainly excreted via the kidney with a terminal half-life of 45 minutes. Metabolism. From left to right:<unk> ,<unk>  acid (the active metabolite), 1,2-dinortravoprost acid, 1,2,3,4-tetranortravoprost acid. Below: reduction of the 13,14-double bond (red) and oxidation of the 15-hydroxy group (blue)
Travoprost
Latanoprost
Carboprost
Iloprost
Bimatoprost
Latanoprostene bunod
Bifluranol
Bimatoprost/timolol