Pitting edema of the lower extremities commonly seen in conditions associated<unk> . Patients with<unk>  are more likely to present with it as a sign of an underlying disease process than as a primary disease process. By itself,<unk>  decreases the total protein concentration in blood plasma, also known as the colloid osmotic pressure, which causes fluid to exit the blood vessels into tissues to equalize the concentrations. This leads to fluid-induced swelling of the extremities known as edema, build-up of fluid in the abdomen known as ascites, and fluid surrounding internal organs known as effusions. Patients also present with nonspecific findings such as fatigue and excessive weakness. Muehrcke's lines are a strong indicator of<unk> .<unk>  by itself may present without any symptoms, as the congenital and complete loss of albumin seen in analbuminemia can be asymptomatic. Alternatively, it can present with death in utero prior to birth or as a disease of adults characterized by edema, fatigue, and hyperlipidemia. The reason for this heterogeneity of presentation is not well understood. Complications By itself,<unk>  can cause hypovolemia and circulatory collapse secondary to decreased oncotic pressure within the vascular system. Due to its metal-binding properties,<unk>  may lead to nutritional deficits including zinc deficiency.<unk>  associated with the nephrotic syndrome can lead to the development of hyperlipidemia, although this is usually in the absence of atherosclerosis. Further, in patients on dialysis,<unk>  is associated with more advanced fluid overload.
Hypoalbuminemia
Bisalbuminemia
Albuminuria
Proteinuria
Proteinopathy
Bilirubinuria
Renal glycosuria
Lipiduria