Physical Features<unk>  is recognized as being part of a spectrum of conditions that affect the Hypothalamic–pituitary–somatotropic axis and cause significant derangements in human growth, development, and metabolism. Along this spectrum of conditions, individuals with<unk>  and growth hormone deficiency display short stature, while individuals with acromegaly and gigantism result in the opposite phenotype of tall stature. In addition to short stature, other characteristic physical symptoms of<unk>  include: prominent forehead, depressed nasal bridge, underdevelopment of mandible, truncal obesity, and micropenis in males. Left untreated, the average height attained by individuals with<unk>  are approximately 4-4.5 feet in women/men respectively. Additional physical features include delayed bone age, hypogonadism, blue sclera, high-pitched voice, acrohypoplasia, sparse hair growth, and crowded teeth. The breasts of females reach normal size, and in some are large in relation to body size. It has been suggested that hyperprolactinemia may contribute to the enlarged breast size. Seizures are frequently seen secondary to hypoglycemia. Some genetic variations decrease intellectual capacity.<unk>  patients also do not develop acne, except temporarily during treatment with IGF-1 (if performed).
Laron syndrome
Hypopituitarism
Jervell and Lange-Nielsen syndrome
STAT5B
Aagenaes syndrome
Cowden syndrome
Dennie–Marfan syndrome
Prader–Willi syndrome