<unk>  is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome. At least 174 disease-causing mutations in this gene have been discovered.<unk>  has a strong sequence homology with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. A splice variant of this gene has been described.
Iduronate-2-sulfatase
Glucuronosyltransferase
Galactosylceramidase
Aromatic L-amino acid decarboxylase
Pegaspargase
Galactose-1-phosphate uridylyltransferase
Phenylalanine hydroxylase
Alpha-galactosidase