Symptoms in asymptomatic infantile-onset (<12 months after birth) and later-onset<unk>  present themselves differently. Of individuals with infantile-onset<unk> , 85–90% display progressive neurologic deterioration in infancy and death before the age of two. Symptoms include irritability, fevers, limb stiffness, seizures, feeding difficulties (like GERD), vomiting, staring episodes, and slowing of mental and motor development. In the first stages of the disease, doctors often mistake the symptoms for those of cerebral palsy. Other symptoms include muscle weakness, spasticity, deafness, optic atrophy, optic nerve enlargement, blindness, paralysis, and difficulty when swallowing. Prolonged weight loss may also occur. 10–15% of individuals with later-onset<unk>  have a much slower disease progression. These individuals may also display symptoms such as esotropia, slurred speech, and slow development or loss of motor milestones.
Krabbe disease
Foster Kennedy syndrome
Batten disease
Sandhoff disease
Stratton Parker syndrome
Warburg Micro syndrome
Fukuyama congenital muscular dystrophy
Dejerine–Sottas disease