The elucidation that the gene defect in<unk>  involves the CARD15/NOD2 gene has stimulated many investigators, to define how this gene operates as part of the innate immune system, that responds to bacterial polysaccharides, such as muramyl dipeptide, to induce signaling pathways that induce cytokine responses, and protect the organism. In<unk>  the genetic defect seems to lead to over expression, and poor control of the inflammatory response leading to widespread granulomatous, inflammation and tissue damage.
Blau syndrome
Robinow syndrome
Cantú syndrome
Pallister–Hall syndrome
Poland syndrome
Gleich's syndrome
Cohen syndrome
Kenny-Caffey syndrome