<unk>  (also called<unk>  carcinomatosis,<unk>  disease (LMD),<unk>  metastasis, neoplastic meningitis, meningeal metastasis and meningeal carcinomatosis) is a rare complication of<unk>  in which the disease spreads from the original tumor site to the meninges surrounding the brain and spinal cord. This leads to an inflammatory response, hence the alternative names neoplastic meningitis (NM), malignant meningitis, or carcinomatous meningitis. The term<unk>  (from the Greek lepto, meaning 'fine' or 'slight') describes the thin meninges, the arachnoid and the pia mater, between which the cerebrospinal fluid is located. The disorder was originally reported by Eberth in 1870. It occurs with<unk> s that are most likely to spread to the central nervous system. The most common<unk> s to include the leptomeninges are breast<unk> , lung<unk> , and melanomas because they can metastasize to the subarachnoid space in the brain which offers a hospitable environment for the growth of metastatic tumor cells. Individuals whose<unk>  has spread to an area of the brain known as the posterior fossa have a greater risk of developing a<unk> . The condition can also arise from primary brain tumor like medulloblastoma.<unk>  disease is becoming more evident because<unk>  patients are living longer and many chemotherapies cannot reach sufficient concentrations in the spinal fluid to kill the tumor cells.
Leptomeningeal cancer
Brain metastasis
Brain abscess
Amoebic brain abscess
Lymphocytic meningoradiculitis
Primary central nervous system lymphoma
Malignant multiple sclerosis
Central nervous system cavernous hemangioma