A<unk>  is one that occurs in the first 28 days of life, though a late presentation is not uncommon (as contrasted with perinatal<unk> , which occurs from 28 weeks gestation through the first 7 days of life). 80% of<unk> s are ischemic, and their presentation is varied, making diagnosis very difficult. The most common manifestation of<unk> s are seizures, but other manifestations include lethargy, hypotonia, apnoea, and hemiparesis. Seizures can be focal or generalized in nature.<unk>  accounts for about 10% of seizures in term neonates. + Disorders that Increase Risk of<unk>  Type of Disorder Disorder Maternal: *Autoimmune disorders *Coagulation disorders *Prenatal cocaine exposure *Congenital heart disease *Diabetes *Trauma Placental: *Placental thrombosis *Placental abruption *Placental infection *Chorioamnionitis Blood, Homocysteine, and Lipid: *Polycythemia *Disseminated intravascular coagulopathy *Prothrombin mutation *Lipoprotein (a) deficiency *Factor VIII deficiency *Factor V Leiden mutation Other Infectious: *Central nervous system (CNS) infection *Systemic infection
Neonatal stroke
Neonatal meningitis
Neonatal encephalopathy
Neonatal seizure
Shaken baby syndrome
Pediatric stroke
Intraventricular hemorrhage
Neonatal diabetes