Occasionally, the anemia is so severe that support with transfusion is required. These patients usually do not respond to erythropoietin therapy. Some cases have been reported that the anemia is reversed or heme level is improved through use of moderate to high doses of pyridoxine (vitamin B6). In severe cases of SBA, bone marrow transplant is also an option with limited information about the success rate. Some cases are listed on MedLine and various other medical sites. In the case of isoniazid-induced<unk> , the addition of B6 is sufficient to correct the anemia. Deferoxamine, a chelating agent, is used to treat iron overload from transfusions. Therapeutic phlebotomy can be used to manage iron overload.
Sideroblastic anemia
Refractory anemia with ring sideroblasts
Myelophthisic anemia
Myomatous erythrocytosis syndrome
Refractory anemia with excess of blasts
Congenital hypoplastic anemia
Hereditary spherocytosis
Thiamine responsive megaloblastic anemia syndrome