The cause of<unk>  is unknown. It usually begins shortly after recovery from a viral infection, such as influenza or chickenpox. About 90% of cases in children are associated with aspirin (salicylate) use. Inborn errors of metabolism are also a risk factor. The association with aspirin has been shown through epidemiological studies. The diagnosis of<unk> " greatly decreased in the 1980s, when genetic testing for inborn errors of metabolism was becoming available in developed countries. A retrospective study of 49 survivors of cases diagnosed as "Reye's Syndrome" showed that the majority of the surviving patients had various metabolic disorders, particularly a fatty-acid oxidation disorder medium-chain acyl-CoA dehydrogenase deficiency. Aspirin There is an association between taking aspirin for viral illnesses and the development of<unk> , but no animal model of<unk>  has been developed in which aspirin causes the condition. The serious symptoms of<unk>  appear to result from damage to cellular mitochondria, at least in the liver, and there is a number of ways that aspirin could cause or exacerbate mitochondrial damage. A potential increased risk of developing<unk>  is one of the main reasons that aspirin has not been recommended for use in children and teenagers, the age group for which the risk of lasting serious effects is highest. In some countries, oral mouthcare product Bonjela (not the form specifically designed for teething) has labeling cautioning against its use in children, given its salicylate content. There have been no cases of<unk>  following its use, and the measure is a precaution. Other medications containing salicylates are often similarly labeled as a precaution. The Centers for Disease Control and Prevention (CDC), the U.S. Surgeon General, the American Academy of Pediatrics (AAP) and the Food and Drug Administration (FDA) recommend that aspirin and combination products containing aspirin not be given to children under 19 years of age during episodes of fever-causing illnesses. Hence, in the United States, it is advised that the opinion of a doctor or pharmacist should be obtained before anyone under 19 years of age is given any medication containing aspirin (also known on some medicine labels as acetylsalicylate, salicylate, acetylsalicylic acid, ASA, or salicylic acid). Current advice in the United Kingdom by the Committee on Safety of Medicines is that aspirin should not be given to those under the age of 16 years, unless specifically indicated in Kawasaki disease or in the prevention of blood clot formation.
Reye syndrome
Zaki syndrome
Kenny-Caffey syndrome
Mungan syndrome
Karak syndrome
Akureyri disease
Sotos syndrome
Eiken syndrome