<unk> , a first in class dihydro-benzofuran-carboxamide, is a selective, high affinity serotonin (5-HT4) receptor agonist with enterokinetic activities.<unk>  alters colonic motility patterns via serotonin 5-HT4 receptor stimulation: it stimulates colonic mass movements, which provide the main propulsive force for defecation. The observed effects are exerted via highly selective action on 5-HT4 receptors:<unk>  has >150-fold higher affinity for 5-HT4 receptors than for other receptors.<unk>  differs from other 5-HT4 agonists such as tegaserod and cisapride, which at therapeutic concentrations also interact with other receptors (5-HT1B/D and the cardiac human ether-a-go-go K+ or hERG channel respectively) and this may account for the adverse cardiovascular events that have resulted in the restricted availability of these drugs. Clinical trials evaluating the effect of<unk>  on QT interval and related adverse events have not demonstrated significant differences compared with placebo.
Prucalopride
Bromopride
Itopride
Cinitapride
Tasimelteon
Lorcaserin
Sibutramine
Palonosetron