<unk>  is a group of mild to severe X-linked recessive disorders that share a common genetic basis. The spectrum of<unk>  disorders includes X-linked complicated corpus callosum agenesis, spastic paraplegia type 1, MASA syndrome, and X-linked hydrocephalus with stenosis of the aqueduct of Sylvius (HSAS). It is also called<unk> CAM syndrome (for the disorder's causative gene) and CRASH syndrome, an acronym for its primary clinical features: corpus callosum hypoplasia, retardation (intellectual disability), adducted thumbs, spasticity, and hydrocephalus.<unk>  can be caused by different variants in<unk> CAM, the gene that provides the information that allows the body to produce<unk>  cell adhesion molecule (sometimes called the<unk>  protein). The<unk>  cell adhesion molecule is a surface protein found on the surface of all neurons. It allows neurons to bind to one another and create synapses (connections where information is passed on from the axons of one neuron to the dendrites and cell body of another). As a result,<unk>  cell adhesion molecule is essential for the structural development of the brain and contributes to the ability to think, move, and develop memories. The type and severity of<unk> CAM variant causing<unk>  in a particular person is directly related to the severity of symptoms and functional impairment that they experience. There is no cure for<unk> , and prognosis is often poor. Life expectancy for people with<unk>  can vary dramatically depending on the severity of the condition, with some dying shortly after birth and others reaching adulthood. Treatment for people with<unk>  is supportive and aims to improve quality of life and minimize functional impairment.
L1 syndrome
TAR syndrome
ATR-16 syndrome
Kufor–Rakeb syndrome
Irlen syndrome
Andersen–Tawil syndrome
MEDNIK syndrome
CAMFAK syndrome