Mitral valve prolapse is a genetically heterogeneous autosomal dominant trait, which can be passed down from one parent to child, who will have a 50% chance to inherit the mutated gene. An association with primary cilia defects has been reported. The mutations were found in the Zinc finger protein DZIP1 gene which regulates ciliogenesis; the same problem was found in mice who also developed MVP with this gene. It was found that primary cilia loss during development results in progressive myxomatous degeneration and profound mitral valve pathology. Myxomatous degeneration of mitral valve is a genetic abnormality mapped to gene Xq28. Other genes associated with MVP are: * 13.q31.3-q32.1 * 16p12.1-p11.2 * Ch16p11.2-p12.1 * 11p15.4 * DCHS1
complications of Marfan syndrome
medical diagnosis of Marfan syndrome
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complications of Noonan syndrome
complications of Long QT syndrome
complications of Treacher Collins syndrome
complications of Hypertrophic cardiomyopathy
picture of Marfan syndrome