Prodrome<unk>  ultimately results in extensive skin involvement with redness, necrosis, and detachment of the top<unk>  layer of the skin and mucosa. Before these severe findings develop, people often have a flu-like prodrome, with a cough, runny nose, fever, decreased appetite and malaise. A history of drug exposure exists on average 14 days (ranging from 1–4 weeks) prior to the onset of symptoms, but may result as early as 48 hours if it is a reexposure. Skin findings Initial skin findings include red-purple, dusky, flat spots known as macules that start on the trunk and spread out from there. These skin lesions then transform into large blisters. The affected skin can then become necrotic or sag from the body and peel off in great swaths. File:Necrolysis<unk> is<unk> a 02.Toxic<unk><unk>  on legs File:Early stage blisters on the back<unk> S patient.alt=The emerging blisters on day 4 of an instance of<unk> s File:TENS patient on day 10.alt=The back of a<unk> s patient on day 10, at the peak of the condition Mucosal findings Nearly all people with<unk>  have oral, eye and genital involvement as well. Painful crusts and erosions may develop on any mucosal surface. The mouth becomes blistered and eroded, making eating difficult and sometimes necessitating feeding through a nasogastric tube through the nose or a gastric tube directly into the stomach. The eyes can become swollen, crusted, and ulcerated, leading to potential blindness. The most common problem with the eyes is severe conjunctivitis. Complications Those who survive the acute phase of<unk>  often suffer long-term complications affecting the skin and eyes. Skin manifestations can include scarring, eruptive melanocytic nevi, vulvovaginal stenosis, and dyspareunia. The epithelium of the trachea, bronchi, or gastrointestinal tract may be involved in SJS and<unk> . Ocular symptoms are the most common complication in<unk> , experienced by 20–79% of those with<unk> , even by those who do not experience immediate ocular manifestations. These can include dry eyes, photophobia, symblepharon, corneal scarring or xerosis, subconjunctival fibrosis, trichiasis, decreased visual acuity, and blindness.
Toxic epidermal necrolysis
Staphylococcal scalded skin syndrome
Poikiloderma vasculare atrophicans
Chickenpox
Streptococcal intertrigo
Skin condition
Cutaneous lupus mucinosis
Staphylococcal infection