<unk> , also spelled<unk> e and<unk> , is a calcineurin inhibitor, used as an immunosuppressant medication. It is a natural product. It is taken by mouth or by injection into a vein for rheumatoid arthritis, psoriasis, Crohn's disease, nephrotic syndrome, and in organ transplants to prevent rejection. It is also used as eye drops for keratoconjunctivitis sicca (dry eyes). Common side effects include high blood pressure, headache, kidney problems, increased hair growth, and vomiting. Other severe side effects include an increased risk of infection, liver problems, and an increased risk of lymphoma. Blood levels of the medication should be checked to decrease the risk of side effects. Use during pregnancy may result in preterm birth; however,<unk>  does not appear to cause birth defects.<unk>  is believed to work by decreasing the function of lymphocytes. It does this by forming a complex with<unk> clophilin to block the phosphatase activity of calcineurin, which in turn decreases the production of inflammatory<unk> tokines by T-lymphocytes.<unk>  was isolated in 1971 from the fungus Tolypocladium inflatum and came into medical use in 1983. It is on the World Health Organization's List of Essential Medicines. In 2019, it was the 195th most commonly prescribed medication in the United States, with more than 2million prescriptions that year. It is available as a generic medication.
Ciclosporin
Voclosporin
Aminophenazone
Mycophenolic acid
Cyclizine
Prednisolone
Azathioprine
Cephalosporin