Relation to other opioids<unk>  has been used in the past as the starting material and prototype of a large class of mainly mild to moderately strong opioids; such as hydrocodone (1920 in Germany), oxycodone (1916 in Germany), dihydrocodeine (1908 in Germany), and its derivatives such as nicocodeine (1956 in Austria). However, these opioids are no longer synthesized from<unk>  and are usually synthesized from other opium alkaloids; specifically thebaine. Other series of<unk>  derivatives include isocodeine and its derivatives, which were developed in Germany starting around 1920. In general, the various classes of morphine derivatives such as ketones, semisynthetics like dihydromorphine, halogeno-morphides, esters, ethers, and others have<unk> , dihydrocodeine, and isocodeine analogues. The<unk>  ester acetylcodeine is a common active impurity in street heroin as some<unk>  tends to dissolve with the morphine when it is extracted from opium in underground heroin and morphine base labs. As an analgesic,<unk>  compares weakly to other opiates. Related to<unk>  in other ways are<unk> oxime, thebacon,<unk> -N-oxide (genocodeine), related to the nitrogen morphine derivatives as is<unk>  methobromide, and heterocodeine, which is a drug six times stronger than morphine and 72 times stronger than<unk>  due to a small re-arrangement of the molecule, viz. moving the methyl group from the 3 to the 6 position on the morphine carbon skeleton. Drugs bearing resemblance to<unk>  in effects due to close structural relationship are variations on the methyl groups at the 3 position including ethylmorphine a.k.a.<unk> ethyline (Dionine) and benzylmorphine (Peronine). While having no narcotic effects of its own, the important opioid precursor thebaine differs from<unk>  only slightly in structure. Pseudocodeine and some other similar alkaloids not currently used in medicine are found in trace amounts in opium as well.
Codeine
Morphine
Nalorphine
Ketazolam
Midazolam
Prilocaine
Benzocaine
Fentanyl