Diagnosis of<unk>  is made by an ophthalmologist in the clinic. Fundus autofluorescence and optical coherence tomography angiography are imaging modalities that can be used in the diagnosis. While fundus autofluorescence is the standard modality for viewing<unk> , optical coherence tomography can offer unique benefits. Optical coherence tomography angiography can help the physician see if there is any subretinal fluid in the eye. This is useful because it could indicate that the patient may be developing wet AMD. Since patients with<unk>  are at higher risk for developing advanced wet AMD (neovascular AMD), this could be especially useful in the monitoring of patients with geography atrophy. If signs of neovascular AMD found, the physician can initiate treatment of wet age-related macular degeneration. Quantification of<unk>  progression Traditionally,<unk>  progression is quantified in terms of the area of retinal pigment epithelium atrophy. Multiple imaging methods can be applied to quantify this area of retinal pigment epithelium atrophy including short-wavelength (blue) fundus autofluorescence imaging, green fundus autofluorescence imaging, and en face optical coherence tomography imaging. However, more recent data suggest that photoreceptor degeneration is not limited to the area of retinal pigment epithelium atrophy, but extends beyond this area. These more subtle changes can be quantified by volumetric analyses of optical coherence tomography data.
Geographic atrophy
Posterior cortical atrophy
Neurofibrillary tangle
Hippocampal sclerosis
Central chromatolysis
Amyloid plaques
Pellucid marginal degeneration
Superficial siderosis