Pharmacodynamics Binding profile Protein cis-flupentixol trans-flupentixol 5-HT1A 8028 — 5-HT2A 87.5 (HFC) — 5-HT2C 102.2 (RC) — mAChRs Neg. Neg. D1 3.5 474 (MB) D2 0.35 120 D3 1.75 162.5 D4 66.3 >1000 H1 0.86 5.73 Acronyms used: HFC – Human frontal cortex receptor MB – Mouse brain receptor RC – Cloned rat receptor Its antipsychotic effects are likely caused by D2 and/or 5-HT2A antagonism, whereas its antidepressant effects at lower doses may be mediated by preferential D2/D3 autoreceptor blockade, resulting in increased postsynaptic activation. Pharmacokinetics
Flupentixol
Tiotropium bromide
Clenbuterol
Sofpironium bromide
Levosalbutamol
Formoterol
Arformoterol
Fluticasone