The best "treatment" of<unk> is prevention. Depending on the medication that has extravasated, there are potential management options and treatments that aim to minimize damage, although the effectiveness of many of these treatments has not been well studied. In cases of tissue necrosis, surgical debridement and reconstruction may be necessary. The following steps are typically involved in managing<unk>  *Stop infusion immediately. Put on sterile gloves. *Replace infusion lead with a disposable syringe. While doing this, do not exert pressure on the<unk> area. *Slowly aspirate back blood back from the arm, preferably with as much of the infusion solution as possible. *Remove the original cannula or other IV access carefully from the arm (removal of the original cannula is not advised by all healthcare institutions, as access to the original cannula by surgeons can be used to help clean extravasated tissue). *Elevate arm and rest in elevated position. If there are blisters on the arm, aspirate content of blisters with a new thin needle. Warm compresses should be placed initially on the site to help diffuse the contrast medium, and cold compresses are used later to help reduce the swelling. *If, for the extravasated medication, substance-specific measures apply, carry them out (e.g. topical cooling, DMSO, hyaluronidase or dexrazoxane may be appropriate). * Recent clinical trials have shown that Totect (USA) or Savene (Europe) (dexrazoxane for<unk>  is effective in preventing the progression of anthracycline<unk> into progressive tissue necrosis. In two open-label, single arm, phase II multicenter clinical trials, necrosis was prevented in 98% of the patients. Dexrazoxane for<unk> is the only registered antidote for<unk> of anthracyclines (daunorubicin, doxorubicin, epirubicin, idarubicin, etc.). *The only FDA approved treatment for vasopressor<unk> is phentolamine Pain management and other measures *Pain management and local supportive care is important, as it can help to minimize the additional risk of infection and superinfection.
Extravasation 
Intravasation
Lymphangiogenesis
Vasculogenesis
Vascular permeability
Vascular recruitment
Thromboregulation
Neovascularization