A diagram showing the cells affected by<unk>  Most people are diagnosed as having<unk>  based on the result of a routine blood test that shows a high white blood cell count, specifically a large increase in the number of circulating lymphocytes. These people generally have no symptoms. Less commonly,<unk>  may present with enlarged lymph nodes. If enlarged lymph nodes are caused by infiltrating<unk> -type cells, a diagnosis of small<unk>  lymphoma (SLL) is made. Less commonly the disease comes to light only after the cancerous cells overwhelm the bone marrow resulting in low red blood cells, neutrophils, or platelets. Or there is fever, night sweats, weight loss, and the person feels tired.<unk>  can be grouped with small<unk>  lymphoma (SLL) as one disease with two clinical presentations. Wherein, with<unk> , diseased cells propagate from within the bone marrow, in SLL they propagate from within the lymphatic tissue.<unk> s are, in virtually all cases, preceded by a particular subtype of monoclonal B-cell lymphocytosis (MBL). This subtype, termed<unk> -type MBL <unk> -type MBL) is an asymptomatic, indolent, and chronic disorder in which people exhibit a mild increase in the number of circulating B-cell lymphocytes. These B-cells are abnormal: they are monoclonal, i.e. produced by a single ancestral B-cell, and have some of the same cell marker proteins, chromosome abnormalities, and gene mutations found in<unk> .<unk> /SLL MBL consist of two groups: low-count<unk> /SLL MBL has monoclonal B-cell blood counts of 9 cells/liter (i.e. 0.5x9/L) while high-count<unk> /SLL MBL has blood monoclonal B-cell counts ≥0.5x9/L but 9/L. Individuals with blood counts of these monoclonal B-cells >5x9/L are diagnosed as having<unk> . Low-count<unk> /SLL MBL rarely if ever progresses to<unk>  while high-count<unk> /SLL MBL does so at a rate of 1-2% per year. Thus,<unk>  may present in individuals with a long history of having high-count<unk> /SLL MBL. There is no established treatment for these individuals except monitoring for development of the disorder's various complications (see treatment of MBL complications) and for their progression to<unk> . Complications Complications include a low level of antibodies in the bloodstream (hypogammaglobulinemia) leading to recurrent infection, warm autoimmune hemolytic anemia in 10–15% of patients, and bone marrow failure.<unk>  may also transform into Richter's syndrome, the development of fast-growing diffuse large B cell lymphoma, prolymphocytic<unk> , Hodgkin's lymphoma, or acute<unk>  in some patients. Its incidence is estimated to be around 5% in people with<unk> . Gastrointestinal (GI) involvement can rarely occur with<unk> . Some of the reported manifestations include intussusception, small intestinal bacterial contamination, colitis, and others. Usually, GI complications with<unk>  occur after Richter transformation. Two cases to date have been reported of GI involvement in<unk>  without Richter's transformation.
Chronic lymphocytic leukemia
Hairy cell leukemia
Chronic neutrophilic leukemia
Infectious mononucleosis
AIDS-related lymphoma
Acute lymphoblastic leukemia
Prolymphocytic leukemia
Persistent polyclonal B-cell lymphocytosis