The<unk>  peptide homes and penetrates tumors through a 3-step process: First, the RGD sequence motif mediates binding to αVβ3 and αVβ5 integrins that are expressed on tumor endothelial cells. Second, upon αV binding, a protease cleavage event is activated, revealing the c-terminal CendR motif (R/KXXR/K) of the peptide. Third, the CendR motif is now able to bind to neuropilin-1, activating an endocytotic/exocytotic transport pathway. The pathway triggered by<unk>  can be used for the enhanced transport of coupled and coadministered anti-cancer drugs into tumors.
IRGD
PANDAS
CoWIN
OHVIRA
MCN
HeRAMS
SCALPEL
TFM-4AS-1