After translation, the<unk>  P1 structure is immediately phosphorylated at all three of the above-mentioned domains. Another round of phosphorylation occurs when the sperm enters the egg, but the function of these phosphorylations is uncertain. The exact secondary and tertiary structure of<unk>  is not known with certainty, but several proposals have been published since the 1970s. The broad consensus is that<unk>  forms beta strand structures that then crosslink through disulphide bonds (and potentially dityrosine and cysteine-tyrosine bonds). When<unk>  P1 binds to DNA, cysteine from the amino terminal of one<unk>  P1 forms disulfide bonds with the cysteine from the carboxy-terminal of another<unk>  P1. By neutralizing the backbone charge<unk>  enables the DNA to more tightly coil. The disulfide bonds function to prevent the dissociation of<unk>  P1 from DNA until the bonds are reduced when the sperm enters the egg. These long<unk>  polymers may then wrap around the DNA within the major groove.
Protamine
Platelet-rich plasma
Fresh frozen plasma
Aminocaproic acid
Pentoxyverine
Cryoprecipitate
Plasminogen 
Prothrombin complex concentrate