Succinic acid has been studied, and shown effective for both<unk> , and MELAS syndrome. A high-fat, low-carbohydrate diet may be followed if a gene on the X chromosome is implicated in an individual's<unk> . Thiamine (vitamin B1) may be given if pyruvate dehydrogenase deficiency is known or suspected. The symptoms of lactic acidosis are treated by supplementing the diet with sodium bicarbonate (baking soda) or sodium citrate, but these substances do not treat the cause of<unk> . Dichloroacetate may also be effective in treating<unk> -associated lactic acidosis; research is ongoing on this substance. Coenzyme Q10 supplements have been seen to improve symptoms in some cases. Clinical trials of the drug EPI-743 for<unk>  are ongoing. In 2016, John Zhang and his team at New Hope Fertility Center in New York, USA, performed a spindle transfer mitochondrial donation technique on a mother in Mexico who was at risk of producing a baby with<unk>  disease. A healthy boy was born on 6 April 2016. However, it is not yet certain if the technique is completely reliable and safe.
Leigh syndrome
Tay–Sachs disease
Maroteaux–Lamy syndrome
Coffin–Siris syndrome
Ohtahara syndrome
Nathalie syndrome
Laurence–Moon syndrome
Kosaki overgrowth syndrome