<unk>  consists of insoluble glass microspheres where yttrium-90 is an integral constituent of the glass. Each milligram contains between 22,000 and 73,000 microspheres. Yttrium-90 is a pure beta emitter (physical half-life of 64.2 hours or 2.67 days) and decays to stable zirconium-90. The average energy of the beta emissions from yttrium-90 is 0.9367 MeV. The<unk>  package insert contains a Black Box warning concerning 5 Pre-treatment high risk factors associated with serious adverse events resulting in 11/12 deaths. Following embolization of the yttrium-90 glass microspheres in tumorous liver tissue, the beta radiation emitted provides a therapeutic effect. The microspheres are delivered into the liver tumor through a catheter placed into the hepatic artery that supplies blood to the tumor. This is usually performed in a hospital's radiology suite and patients remain conscious throughout the procedure. The microspheres are unable to pass through the vasculature of the liver due to arteriolar capillary blockade and are trapped in the tumor. There they exert a local radiotherapeutic effect with some damage to surrounding normal liver tissue.<unk>  was issued a Class 2 Device Recall from the FDA in October 2016.
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