Genetic testing is necessary to identify the syndrome. The DNA test is necessary sometimes, because symptoms may not be sufficient to definitely diagnose this condition. Differential diagnosis The symptoms of<unk>  and NF-1 are very similar; An important difference between<unk>  and NF-1 is the absence of tumor growths Lisch nodules and neurofibromas which are common in NF-1. A genetic test is often the only way to make sure a person has LS and not NF-1; the similarity of symptoms stem from the fact that the different genes affected in the two syndromes code for proteins that carry out a similar task in the same reaction pathway.
Legius syndrome
Neurofibromatosis type I
Shone's syndrome
Duane-radial ray syndrome
Alien hand syndrome
Bowen–Conradi syndrome
Burnside–Butler syndrome
Hunan hand syndrome