<unk>  agglutinin disease may be managed successfully using protective measures (clothing) alone in most cases. Special protective clothing is sometimes necessary in extreme cases. Therapy is directed at serious symptoms and the underlying disorder, if any is found. Keep in mind that the idiopathic variety of<unk>  agglutinin disease is generally a benign disorder with prolonged survival and spontaneous exacerbations and remissions in the course of the disease. Acute post infectious syndromes usually resolve spontaneously. Anemia is generally mild. Only patients who have serious symptoms related to anemia or have a Raynaud type syndrome that constitutes a threat to life or quality of life require active therapy. The presence of an associated malignancy requires specific therapy.<unk>  agglutinin disease is so uncommon in children that no specific recommendations for therapy are available. Intravenous immunoglobulin (IVIG) was used successfully in an infant with IgA-associated autoimmune hemolytic anemia. Splenectomy Splenectomy is usually ineffective for the treatment of<unk>  agglutinin disease because the liver is the predominant site of sequestration. However, if the patient has splenomegaly, then the disease may respond to splenectomy. More importantly, a lymphoma localized to the spleen may only be found after splenectomy. Diet and activity Patients with<unk>  agglutinin disease should include good sources of folic acid, such as fresh fruits and vegetables, in their diet. Activities for these individuals should be less strenuous than those for healthy people, particularly for patients with anemia. Jogging in the<unk>  could be very hazardous because of the added windchill factor. Consultations A hematologist-oncologist working in collaboration with a blood banker is helpful in complicated cases of<unk>  agglutinin disease. Careful planning and coordination with multiple personnel are needed if patients are to undergo a procedure during which their body temperature could fall.
Cold autoimmune hemolytic anemia
Warm antibody autoimmune hemolytic anemia
Acquired hemolytic anemia
Mixed autoimmune hemolytic anemia
Contaminated haemophilia blood products
Donath–Landsteiner hemolytic anemia
Drug-induced autoimmune hemolytic anemia
Drug-induced nonautoimmune hemolytic anemia