Pharmacodynamics<unk>  has been<unk> posed to have several mechanisms of action, both through potentiation of GABAA receptor activity and therefore acting as a GABAA receptor positive allosteric modulator, thereby slowing the channel-closing time. At high doses,<unk>  may be able to activate GABAA receptors in the absence of GABA, behaving as a GABAA receptor agonist as well.<unk>  analogs have been shown to also act as sodium channel blockers. Some research has also suggested that the endocannabinoid system may contribute significantly to<unk> 's anesthetic action and to its unique<unk> perties. EEG research upon those undergoing general anesthesia with<unk>  finds that it causes a<unk> minent reduction in the brain's information integration capacity. Pharmacokinetics A 20 ml ampoule of 1%<unk>  emulsion, as sold in Australia by alt=Large vial filled with milky white fluid<unk>  is highly<unk> tein-bound in vivo and is metabolised by conjugation in the liver. The half-life of elimination of<unk>  has been estimated to be between 2 and 24 hours. However, its duration of clinical effect is much shorter, because<unk>  is rapidly distributed into peripheral tissues. When used for IV sedation, a single dose of<unk>  typically wears off within minutes.<unk>  is versatile; the drug can be given for short or<unk> longed sedation, as well as for general anesthesia. Its use is not associated with nausea as is often seen with opioid medications. These characteristics of rapid onset and recovery along with its amnestic effects have led to its widespread use for sedation and anesthesia.
Propofol
Metharbital
Remifentanil
Etomidate
Ketamine
Ketazolam
Fentanyl
Alfentanil