Common adverse drug reactions (ADRs) associated with the use of<unk>  include: hyperkalaemia, hypotension, dizziness, and reduced renal clearance.<unk>  may have a lower incidence than spironolactone of sexual side effects such as feminization, gynecomastia, impotence, low sex drive and reduction of size of male genitalia. This is because other antimineralocorticoids have structural elements of the progesterone molecule, causing progestogenic and antiandrogenic outcomes. When considering taking these medicines, it is important to note the variations in their ability to offset the nongenomic effects of aldosterone. Currently, there is not enough evidence available from the randomized controlled trials on side effects of<unk>  to do a benefit versus risk assessment in people with primary hypertension. Interactions<unk>  is primarily metabolized by the cytochrome P450 enzyme CYP3A4. Thus the potential exists for adverse drug interactions with other drugs that induce or inhibit CYP3A4. Specifically, the concomitant use of the CYP3A4 potent inhibitors ketoconazole and itraconazole is contraindicated. Other CYP3A4 inhibitors including erythromycin, saquinavir, and verapamil should be used with caution. Other drugs that increase potassium concentrations may increase the risk of hyperkalemia associated with<unk>  therapy, including salt substitutes, potassium supplements and other potassium-sparing diuretics.
Eplerenone
Cyclothiazide
Chlorothiazide
Canrenone
Spirorenone
Spironolactone
Hydrochlorothiazide
Amiloride