Genetic, environmental, and psychological factors seem to be important in the development of<unk> . Studies have shown that<unk>  has a genetic component even though there is a predominant influence of environmental factors. There is evidence that abnormalities occur in the gut flora of individuals who have<unk> , such as reduced diversity, a decrease in bacteria belonging to the phylum Bacteroidota, and an increase in those belonging to the phylum Bacillota. The changes in gut flora are most profound in individuals who have diarrhoea predominant<unk> . Antibodies against common components (namely flagellin) of the commensal gut flora are a common occurrence in<unk>  affected individuals. Chronic low-grade inflammation commonly occurs in<unk>  affected individuals with abnormalities found including increased enterochromaffin cells, intraepithelial lymphocytes, and mast cells resulting in chronic immune-mediated inflammation of the gut mucosa.<unk>  has been reported in greater quantities in multigenerational families with<unk>  than in the regular population. It is believed that psychological stress can induce increased inflammation and thereby cause<unk>  to develop in predisposed individuals.
Irritable bowel syndrome
Bile acid malabsorption
Crohn's disease
Colorectal cancer
Ulcerative colitis
Non-celiac gluten sensitivity
IBS
Inflammatory bowel disease