<unk> 's disease displaying typical trichilemmomas on the bilateral dorsal hands As<unk> 's disease is a multi-system disorder, the physical manifestations are broken down by organ system: Skin Adolescent patients affected with<unk>  develop characteristic lesions called trichilemmomas, which typically develop on the face, and verrucous papules around the mouth and on the ears. Oral papillomas are also common. Furthermore, shiny palmar keratoses with central dells are also present. At birth or in childhood, classic features of<unk> 's include pigmented genital lesions, lipomas, epidermal nevi, and cafe-au-lait spots. Squamous cell carcinomas of the skin may also occur. Thyroid Two thirds of patients suffer from thyroid disorders, and these typically include benign follicular adenomas or multinodular goiter of the thyroid. Additionally,<unk> 's patients are more susceptible to developing thyroid cancer than the general population. It is estimated that less than 10 percent of individuals with<unk>  may develop follicular thyroid cancer. Cases of papillary thyroid cancer have been reported as well. Female and Male Genitourinary Females have an elevated risk of developing endometrial cancers, which is highest for those under the age of 50. Currently, it is not clear whether uterine leiomyomata (fibroids) or congenital genitourinary abnormalities occur at an increased rate in<unk>  patients as compared to the general population. The occurrence of multiple testicular lipomas, or testicular lipomatosis, is a characteristic finding in male patients with<unk> . Gastrointestinal Polyps are extremely common as they are found in about 95% of<unk>  patients undergoing a colonoscopy. They are numerous ranging from a few to hundreds, usually of the hamartomatous subtype, and distributed across the colon as well as other areas within the gastrointestinal tract. Other types of polyps that may be encountered less frequently include ganglioneuromatous, adenomatous, and lymphoid polyps. Diffuse glycogenic acanthosis of the esophagus is another gastrointestinal manifestation associated with<unk> . Breast Females are at an increased risk of developing breast cancer, which is the most common malignancy observed in<unk> 's patients. Although some cases have been reported, there is not enough evidence to indicate an association between<unk>  and the development of male breast cancer. Up to 75% demonstrate benign breast conditions such as intraductal papillomatosis, fibroadenomas, and fibrocystic changes. However, there is currently not enough evidence to determine if benign breast disease occurs more frequently in<unk> 's patients as compared to individuals without a hereditary cancer syndrome. Central Nervous System Macrocephaly is observed in 84% of patients with<unk> . It typically occurs due to an abnormally enlarged brain, or megalencephaly. Patients may also exhibit dolichocephaly. Varying degrees of autism spectrum disorder and intellectual disability have been reported as well. Lhermitte-Duclos disease is a benign cerebellar tumor that typically does not manifest until adulthood in patients with<unk> .
Cowden syndrome
Juvenile polyp
Laron syndrome
Fox–Fordyce disease
Jervell and Lange-Nielsen syndrome
Danon disease
Pott disease
Scott syndrome