H. capsulatum is found throughout the world. It is endemic in certain areas of the United States, particularly in states bordering the Ohio River valley and the lower Mississippi River. The humidity and acidity patterns of soil are associated with endemicity. Bird and bat droppings in soil promote the growth of Histoplasma. Contact with such soil aerosolizes the microconidia, which can infect humans. It is also common in caves in Southern and East Africa. Positive Histoplasmin skin tests occur in as many as 90% of the people living in areas where H. capsulatum is common, such as the eastern and central United States. In Canada, the St. Lawrence River Valley is the site of the most frequent infections, with 20–30% of the population testing positive. A review of reported cases in 2018 showed disease presence throughout Southeast Asia, In India, the Gangetic West Bengal is the site of most frequent infections, with 9.4% of the population testing positive. H. c. capsulatum was isolated from the local soil proving endemicity of<unk>  in West Bengal.
Histoplasmosis
Tuberculosis
Toxoplasmosis
Talaromycosis
African histoplasmosis
Emmonsiosis
Lobomycosis
Zygomycosis