Affects males 50% of the time if mother is a carrier for the gene. Children are generally asymptomatic until 6–9 months of age when maternal IgG decreases. Present with recurrent infections with Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, hepatitis virus, and enterovirus CNS infections. Examination shows lymphoid hypoplasia (tonsils and adenoids, no splenomegaly or lymphadenopathy). There is significant decrease in all immunoglobulins.
X-linked agammaglobulinemia
Severe combined immunodeficiency
X-linked severe combined immunodeficiency
Common variable immunodeficiency
Combined immunodeficiencies
Primary immunodeficiency
Selective immunoglobulin A deficiency
Transient hypogammaglobulinemia of infancy