<unk>  (type IV<unk>  dyslipidemia) is a genetic disorder characterized by the liver overproducing very-low-density lipoproteins (VLDL). As a result, an afflicted individual will have an excessive number of VLDL and triglycerides on a lipid profile. This genetic disorder usually follows an autosomal dominant inheritance pattern. The disorder presents clinically in patients with mild to moderate elevations in triglyceride levels.<unk>  is typically associated with other co-morbid conditions such as hypertension, obesity, and hyperglycemia. Individuals with the disorder are mostly heterozygous in an inactivating mutation of the gene encoding for lipoprotein lipase (LPL). This sole mutation can markedly elevate serum triglyceride levels. However, when combined with other medications or pathologies it can further elevate serum triglyceride levels to pathologic levels. Substantial increases in serum triglyceride levels can lead to certain clinical signs and the development of acute pancreatitis.<unk>  falls in the Fredrickson-Levy and Lee’s (FLL) phenotypes. The phenotypes include types I, IIa, IIb, III, IV, and V dyslipidemias.<unk>  is considered a type IV<unk>  dyslipidemia it is distinguished from other dyslipidemias based on the individual’s lipid profile.<unk>  separates itself from other dyslipidemias with significantly high triglycerides and low HDL levels. It is important to recognize that co-morbid conditions that often concomitantly exist with the disorder can further alter the lipid panel.
Familial hypertriglyceridemia
Familial hypercholesterolemia
Combined hyperlipidemia
Lipoatrophic diabetes
Familial dysbetalipoproteinemia
Abetalipoproteinemia
Citrullinemia type I
HIDEA syndrome