<unk>  refers to a group of disorders that involve the formation of blisters following trivial trauma. Over 300 mutations have been identified in this condition. They have been classified into the following types:<unk>  simplex<unk>  simplex <unk> S) is a form of<unk>  that causes blisters at the site of rubbing. It typically affects the hands and feet, and is typically inherited in an autosomal dominant manner, affecting the keratin genes KRT5 and KRT14. Therefore, there is a failure in keratinisation, which affects the integrity and the ability of the skin to resist mechanical stresses. Junctional<unk>  Junctional<unk>  (JEB) is an inherited disease affecting laminin and collagen. This disease is characterised by blister formation within the lamina lucida of the basement membrane zone and is inherited in an autosomal recessive manner. It also presents with blisters at the site of friction, especially on the hands and feet, and has variants that can occur in children and adults. Less than one person per million people is estimated to have this form of<unk> . Dystrophic<unk>  Dystrophic<unk>  (DEB) is an inherited variant affecting the skin and other organs. DEB is caused by genetic defects (or mutations) within the human COL7A1 gene encoding the protein type VII collagen (collagen VII). DEB-causing mutations can be either autosomal dominant or autosomal recessive. Epidermis bullosa pruriginosa and albopapuloid<unk>  (Pasini's disease) are rare subtypes of this disease. Other genetic OMIM Name Locus Gene<unk> , lethal acantholytic 6p24 DSP<unk>  acquisita Acral peeling
Epidermolysis bullosa
Pemphigus vulgaris
Tinea imbricata
Bullous pemphigoid
Linitis plastica
Diabetic bulla
Ichthyosis bullosa of Siemens
Lichen myxedematosus