Therapeutic (green) and side effect dose response curves (red) illustrating a typical starting and progressively increasing titrated doses (arrows).<unk>  is the process of adjusting the dose of a medication for the maximum benefit without adverse effects. When a<unk>  has a narrow therapeutic index,<unk>  is especially important, because the range between the dose at which a<unk>  is effective and the dose at which side effects occur is small. Some examples of the types of<unk> s commonly requiring<unk>  include insulin, anticonvulsants, blood thinners, anti-depressants, and sedatives.<unk> g off of a medication instead of stopping abruptly is recommended in some situations. Glucocorticoids should be tapered after extended use to avoid adrenal insufficiency.<unk>  is also used in phase I of clinical trials. The experimental<unk>  is given in increasing dosages until side effects become intolerable. A clinical trial in which a suitable dose is found is called a dose-ranging study.
Drug titration
Early goal-directed therapy
Antipsychotic switching
Breakthrough therapy
Target controlled infusion
Directed therapy
Medicines reconciliation
Stimulant maintenance