<unk>  is officially indicated for the treatment of various types of bacterial infections. It is used as an antibiotic in the treatment of Lyme disease, acne, and bronchitis. Resistance, though, is gradually becoming more common, and<unk>  is now rarely used for treatment of infections. It is widely used (though off-label in many countries including the United States) in the treatment of hyponatremia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) when fluid restriction alone has been ineffective. Physiologically, this works by reducing the responsiveness of the collecting tubule cells to ADH. The use in SIADH actually relies on a side effect;<unk>  induces nephrogenic diabetes insipidus (dehydration due to the inability to concentrate urine). The use of<unk>  in SIADH was first reported in 1975, and, in 1978, a larger study found it to be more effective and better tolerated than lithium carbonate, the only available treatment at the time.<unk>  used to be the drug of choice for treating SIADH. Meanwhile it might be superseded, now that vasopressin receptor antagonists, such as tolvaptan, became available.
Demeclocycline
Diprobase
Tibolone
Meclofenamic acid
Ciclesonide
Aceclofenac
Gadoteric acid
Allopurinol