Mortality, though it has lessened to a limited degree, at least in developed countries with timely access to initial and tertiary care, varies where the chance of survival is diminished as the number of<unk> s involved increases. Mortality in<unk>  from septic shock (which itself has a high mortality of 25-50%), and from<unk>  traumas, especially if not rapidly treated, appear to be especially severe. If more than one<unk>  system is affected, the mortality rate is still higher, and this is especially the case when five or more systems or<unk> s are affected. Old age is a risk factor in and of itself, and immunocompromised patients, such as with cancer or AIDS or a transplant, are at risk. Prognosis must take into account any co-morbidities the patient may have, their past and current health status, any genetic or environmental vulnerabilities they have, the nature and type of the illness or injury (as an example, data from COVID-19 is still being analyzed, whereas other cases from long-existing illnesses are much better understood), and any resistance to drugs used to treat microbial infections<unk> y hospital-acquired co-infection. Earlier and aggressive treatment, the use of experimental treatments, or at least modern tools such as ventilators, ECMO, dialysis, bypass, and transplantation, especially at a trauma center, may improve outcomes in certain cases, but this depends in part on speedy and affordable access to high-quality care, which many areas lack. Measurements of lactate, cytokines, albumin and other proteins, urea, blood oxygen and carbon dioxide levels, insulin, and blood sugar, adequate hydration, constant monitoring of vital signs, good communication within and between facilities and staff, and adequate staffing, training, and charting are important in<unk> , as in any serious illness. In patients with sepsis, septic shock, or<unk>  that is due to major trauma, the rs1800625 polymorphism is a functional single nucleotide polymorphism, a part of the receptor for advanced glycation end products (RAGE) transmembrane receptor gene (of the immunoglobulin superfamily) and confers host susceptibility to sepsis and<unk>  in these patients.
Multiple organ dysfunction syndrome
Cytokine release syndrome
Tumor lysis syndrome
Systemic inflammatory response syndrome
Macrophage activation syndrome
Decompression sickness
Pulmonary-renal syndrome
Culture-bound syndrome