The detection of tumours specific to<unk><unk>  is important in the<unk> 's diagnosis. In individuals with a family history of<unk><unk> , one hemangioblastoma, pheochromocytoma or renal cell carcinoma may be sufficient to make a diagnosis. As all the tumours associated with<unk><unk>  can be found sporadically, at least two tumours must be identified to diagnose<unk><unk>  in a person without a family history. Genetic diagnosis is also useful in<unk><unk>  diagnosis. In hereditary<unk><unk> , techniques such as the Southern blot and gene sequencing can be used to analyse DNA and identify mutations. These tests can be used to screen family members of those afflicted with<unk><unk> ; de novo cases that produce genetic mosaicism are more difficult to detect because mutations are not found in the white blood cells that are used for genetic analysis. Classification<unk><unk>  can be subdivided according to the clinical manifestations, although these groups often correlate with certain types of mutations present in the<unk>  gene.
Von Hippel–Lindau disease
Mowat–Wilson syndrome
Neurofibromatosis type 4
Hurler–Scheie syndrome
Lesch–Nyhan syndrome
Neurofibromatosis type II
Neurofibromatosis type I
Stratton Parker syndrome