<unk>  is widely regarded as chronic, as opposed to acute, inflammation of the central nervous system. Acute inflammation usually follows injury to the central nervous system immediately, and is characterized by inflammatory molecules, endothelial cell activation, platelet deposition, and tissue edema. Chronic inflammation is the sustained activation of glial cells and recruitment of other immune cells into the brain. It is chronic inflammation that is typically associated with neurodegenerative diseases. Common causes of chronic<unk>  include: * Toxic metabolites * Autoimmunity * Aging * Microbes * Viruses * Traumatic brain injury * Spinal cord injury * Air pollution * Passive smoke The initiation of<unk>  in the body. (Created with BioRender.com) Viruses, bacteria, and other infectious agents activate the body’s defense systems and cause immune cells to protect the designed area from the damage. Some of these foreign pathogens can trigger a strong inflammatory response that can compromise the integrity of the blood-brain barrier and thus change the flow of inflammation in nearby tissue. The location along with the type of infection can determine what type of inflammatory response is activated and whether specific cytokines or immune cells will act.
Neuroinflammation
Neurogenic inflammation
Cerebral softening
Neuroregeneration
Central nervous system fatigue
Excitotoxicity
Transflammation
Drug delivery to the brain