* Clinical symptoms of the disease: * Seborrhoeic areas * This is defined as areas where excess oil and sebum is released. * Overall greasy or scaly skin either in the central chest and back or in the folds of the skin. * Fragile or poorly formed fingernails * Nail disease leading to V-shaped nicks at the edge of the nail. * Rash that covers many areas of the body * The rash is often associated with a strong unpleasant odor * The rash can be aggravated by heat, humidity, and exposure to sunlight. * Mucosal manifestation * White cobblestone pattern of small papules * Overgrowth of gums * Usually affects the mouth, esophagus, rectum, vulva, vagina * Oral symptoms can be diagnosed by a routine dental examination * Other symptoms and their overall prevalence in the affected population: * In 80 to 90% of patients * Acrokeratosis verruciformis * Acrokeratosis is characterized by several small wart-like and flat-topped bumps that line the skin on typically the hand and feet. * Hypermelanotic macule * Patches on the skin that contain excess pigment, they often appear as dark patches in the skin. * Pruritus * Itching * Subungual hyperkeratotic fragments * Thickened skin that is often discolored, under nails, on either hands or feet. * Palmar pits * Usually red in color, they are pits or depressions in the palms or soles of the hands and feet. * In 30 to 79% of patients * Abnormal hair morphology * Acne conglobata * Typically described as cystic acne
Darier's disease
Bright's disease
Dent's disease
Minor's disease
Texier's disease
Chandler's disease
Tornwaldt's disease
Gorham's disease