APS-1 is due to problems with immune tolerance. APS-1 causes considerable reactions with both interferon omega and interferon alpha. There may also be a reaction against interleukin 22. This leads to damage to endocrine organs. Common problems include hypercalcaemia and nephrocalcinosis (due to a lack of calcitonin from the thyroid), and pituitary problems (such as growth hormone deficiency). Antibodies against NLRP5 may lead to hypoparathyroidism.
types of Autoimmune polyendocrine syndrome
symptoms of Autoimmune polyendocrine syndrome type 1
symptom of Autoimmune polyendocrine syndrome type 1
medical cause of Zollinger–Ellison syndrome
complications of Hashimoto's thyroiditis
symptom of Maroteaux–Lamy syndrome
complications of Graves' disease
medical cause of Hyperthyroidism