<unk>  is an autosomal dominant trait that has variable expressiveness and incomplete penetrance.<unk>  can be passed through inheritance and presents as either an isolated anomaly or a component manifestation of a genetic syndrome. Many syndromes are associated with<unk> , including those listed below. But the phenotype, by itself, is not a sensitive or specific diagnostic test for these syndromes (it is present in up to 18% of the normal population). * Down syndrome * Turner syndrome * Aarskog syndrome * Carpenter syndrome * Seckel syndrome * Cornelia de Lange syndrome * Orofaciodigital syndrome 1 * 13q deletion syndrome * XXYY syndrome * Silver–Russell syndrome * Andersen-Tawil syndrome * Noonan syndrome * Ehlers–Danlos syndrome When identified prenatally, in conjunction with other features of Down syndrome, for example during obstetric ultrasonography, it may be an indication for intrauterine sampling for fetal chromosome analysis.
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