The general cause of<unk>  is the misfolding of a specific protein precursor depending on the<unk>  type. Protein precursors include immunoglobulin-derived light chains and transthyretin mutations. The misfolding of the protein causes it to have insoluble beta-pleated sheets, creating an amyloid. Amyloid, the aggregation, or clumping, of proteins, is resistant to degradation by the body. Amyloids are mostly fibrils, while also containing a P component, apolipoprotein, collagen, fibronectin, and laminin. The P component, a pentameric protein, stabilizes the fibrils of the amyloid, which reduces their clearance from the body. Deposits of the amyloids can occur throughout the body, including the heart, liver, kidneys, spleen, adrenal glands, and bones. Deposits in the extracellular<unk>  space can stiffen the heart, resulting in restriction of the ventricles. This restriction in ventricular motion results in a decreased ability for the heart to pump efficiently, leading to the various symptoms associated with<unk> .
Cardiac amyloidosis
Amyloid cardiomyopathy
Viral cardiomyopathy
Diabetic cardiomyopathy
HIV associated cardiomyopathy
Alcoholic cardiomyopathy
Coxsackievirus-induced cardiomyopathy
Dilated cardiomyopathy