Complex of α, β tubulin subunits and<unk> .<unk>  is shown as yellow stick.<unk>  is one of several cytoskeletal drugs that target tubulin.<unk> -treated cells have defects in mitotic spindle assembly, chromosome segregation, and cell division. Unlike other tubulin-targeting drugs, such as colchicine, that inhibit microtubule assembly,<unk>  stabilizes the microtubule polymer and protects it from disassembly. Chromosomes are thus unable to achieve a metaphase spindle configuration. This blocks the progression of mitosis and prolonged activation of the mitotic checkpoint triggers apoptosis or reversion to the G0-phase of the cell cycle without cell division. The ability of<unk>  to inhibit spindle function is generally attributed to its suppression of microtubule dynamics, but other studies have demonstrated that suppression of dynamics occurs at concentrations lower than those needed to block mitosis. At the higher therapeutic concentrations,<unk>  appears to suppress microtubule detachment from centrosomes, a process normally activated during mitosis.<unk>  binds to the beta-tubulin subunits of microtubules.
Paclitaxel
Doxorubicin
Ifosfamide
Docetaxel
Lipoplatin
Bendamustine
Epirubicin
Vincristine