<unk>  is inherited in an autosomal recessive manner. This means the defective gene responsible for the disorder is located on an autosome, and two copies of the defective gene (one inherited from each parent) are required in order to be born with the disorder. This gene is called PSMB8 and is located on chromosome 6 at 6p21.32. This gene codes for a subunit called immunoproteasomes that are found immune system cells. These cells are crucial for identifying viral proteins. It has been noted that malfunctions in PSMB8 cause the destruction of proteins which leads to muscle degradation and fat loss. The parents of an individual with an autosomal recessive disorder both carry one copy of the defective gene, but usually do not experience any signs or symptoms of the disorder. Although variations in severity has little clinical support, onset of<unk>  can vary from ages 1-18.
Nakajo syndrome
DeSanto-Shinawi syndrome
Currarino syndrome
Mungan syndrome
Rotor syndrome
Baggio–Yoshinari syndrome
Ardalan–Shoja–Kiuru syndrome
Okamoto syndrome