High doses over a long period of time are associated with fibrosing colonopathy. Due to this association a maximum dose of 10,000 IU of lipase per kilogram per day is recommended. Though never reported there is a theoretical risk of a viral infection as they are from pigs.
Pancreatic enzymes 
Bile acid
Alpha-amylase
Lipoprotein
Acute-phase protein
AST/ALT ratio
Lumirubin
Gastrointestinal hormone