A<unk>  <unk><unk>  is a type of medication which affects gonadotropins and sex hormones. They are used for a variety of indications including in fertility medicine and to lower sex hormone levels in the treatment of hormone-sensitive cancers such as prostate cancer and breast cancer, certain gynecological disorders like heavy periods and endometriosis, high testosterone levels in women, early puberty in children, as a part of transgender hormone therapy, and to delay puberty in transgender youth among other uses.<unk><unk> s are given by injections into fat, as implants placed into fat, and as nasal sprays. Side effects of<unk><unk> s are related to sex hormone deficiency and include symptoms of low testosterone levels and low estrogen levels such as hot flashes, sexual dysfunction, vaginal atrophy, penile atrophy, osteoporosis, infertility, and diminished sex-specific physical characteristics. They are<unk> s of the<unk> receptor and work by increasing or decreasing the release of gonadotropins and the production of sex hormones by the gonads. When used to suppress gonadotropin release,<unk><unk> s can lower sex hormone levels by 95% in both sexes.<unk> was discovered in 1971, and<unk> analogues were introduced for medical use in the 1980s. Their nonproprietary names usually end in -relin. The most well-known and widely used<unk> analogues are leuprorelin (brand name Lupron) and triptorelin (brand name Decapeptyl).<unk> analogues are available as generic medications. Despite this, they continue to be very expensive.
Gonadotropin-releasing hormone agonist
Gonadotropin-releasing hormone antagonist
Gonadotropin-releasing hormone modulator
Prolactin modulator
Antiandrogen
Thyroid blocker
17α-Alkylated anabolic steroid
Steroidal antiandrogen