An ivory vertebra due to probable<unk>  diseaseThe first clinical manifestation of<unk> 's disease is usually an elevated alkaline phosphatase in the blood.<unk> 's disease of right innominate bone. Man of 80 years age.<unk> 's disease may be diagnosed using one or more of the following tests: *<unk> ic bone has a characteristic appearance on X-rays. A skeletal survey is therefore indicated. * An elevated level of alkaline phosphatase in the blood in combination with normal calcium, phosphate, and aminotransferase levels in an elderly patient are suggestive of<unk> 's disease. * Markers of bone turnover in urine eg. Pyridinoline * Elevated levels of serum and urinary hydroxyproline are also found. * Bone scans are useful in determining the extent and activity of the condition. If a bone scan suggests<unk> 's disease, the affected bone(s) should be X-rayed to confirm the diagnosis. Differential diagnosis
Paget's disease of bone
Diffuse idiopathic skeletal hyperostosis
Albright's hereditary osteodystrophy
Giant-cell tumor of bone
Fibrous dysplasia of bone
Tumoral calcinosis
Metabolic bone disease
Oncogenic osteomalacia