In well-resourced settings, where the disease can be detected and treated early, the risk of death is 10%. In resource-poor settings, the risk of death from the disease is more than 40%. For those with incomplete treatment, reappearance of symptoms after a period of disease remission ("recrudescence") can occur. Then, hospital admission is needed for intravenous antibiotics. For those who have completed treatment successfully, recurrence can also occur due to recrudescence or new<unk>  infection. With better therapies, the recrudescence rate has reduced from 10 to 5%. The new infection is now more common than recrudescence. Risk factors of recrudescence include the severity of disease (patients with positive blood cultures or multifocal disease have a higher risk of relapse), choice of antibiotic for eradication therapy (doxycycline monotherapy and fluoroquinolone therapy are not as effective), poor compliance with eradication therapy and duration of eradication therapy less than 8 weeks. Underlying medical conditions such as diabetes mellitus, chronic kidney disease, and cancer can worsen the long-term survival and disability of those who recover from infection. The most severe complication of<unk>  is encephalomyelitis. It can cause quadriparesis (muscle weakness in all the limbs), partial flaccid paraparesis (muscle weakness of both legs), or foot drop. For those with previous<unk> -associated bone and joint infections, complications such as sinus infection, bone and joint deformities with limited range of motion can occur.
Melioidosis
Sarcoidosis
Tuberculosis
Gamasoidosis
Amyloidosis
Miliary tuberculosis
Chronic pulmonary aspergillosis
Extrapulmonary tuberculosis