<unk>  is a benzodiazepine. It is a white, crystalline substance, very slightly soluble in water, and sparingly soluble in alcohol. Synthesis Pharmacologically active metabolite of diazepam, q.v. Prepn: S. C. Bell, (1965 to Am. Home. Prod.). See also: E. Reeder et al., and (1967, 1968, both to Hoffmann-La Roche). N-oxides are prone to undergo the Polonovski rearrangement when treated with acetic anhydride, and this was illustrated by the synthesis of oxazepam. It is not surprising that the N-methyl analogue (1) also undergoes this process, and hydrolysis of the resulting acetate gives<unk>  (2). Care must be exacted with the conditions, or the inactive rearrangement product (3) results.
Temazepam
Oxazepam
Medazepam
Diclazepam
Halazepam
Camazepam
Cinolazepam
Quazepam