LPF is an infiltrative, poorly circumscribed tumor that on microscopic histopathological analysis consists of oval- or spindle-shaped fibroblast-like cells interspersed with muscle cells (as evidenced by the presence of the easily recognizable myofibril portions of muscle cells). These cells give the appearance of infiltrating fat tissues. This fat tissue is composed of adipocyte-like cells, some of which are distinctly abnormal in that they contain one relative large vacuole, resemble lipoblasts (precursors to mature adipocytes), and show considerable variations in their appearances. The distinctly abnormal lipoblasts have been referred to as "pseudolipoblasts". Overall, fat tissue represents >50% of the LPF tumors. As detected by immunohistochemical analyses, LPF tumor tissues also contain scattered foci of cells that express the tumor marker proteins CD99, SMA (i.e. smooth muscle actin), CD34, and less frequently S100 and/or epithelial membrane antigen.
Lipofibromatosis
Actinic elastosis
Phakomatosis
Fibromatosis
Pyogenic granuloma
Fibrin ring granuloma
Lipoblastomatosis
Universal angiomatosis