A number of diseases can cause<unk> , including the following: *Endocrine, such as hyperparathyroidism, osteoporosis, kidney failure. *Gastrointestinal or systemic, such as celiac disease and non-celiac gluten sensitivity (both often occur without obvious digestive symptoms), inflammatory bowel disease (including Crohn's disease and ulcerative colitis). *Hematologic, such as Cushing's syndrome, histiocytosis, multiple myeloma and sickle cell anaemia. *Infectious, such as Lyme disease and osteomyelitis. *Neurological, such as spinal cord injury and vertebral degeneration. *Oncologic, such as<unk>  metastasis and leukemia. *Rheumatic, such as ankylosing spondylitis, rheumatoid arthritis, gout. *Others, such as fractures, osteoarthritis, Paget's disease of<unk>  (also termed osteitis deformans or just Paget's disease). Causes in children *Acute leukemia. *Acute rheumatic fever, a very dangerous disease that can cause permanent cardiac damage. *Untreated celiac disease, which can present without gastrointestinal symptoms. *Fibromyalgia, which affects people of all ages. *Growing pains. *Hypermobility syndrome can present with knee or ankle pain. *Lupus. *Henoch–Schönlein purpura. *Fibrous dysplasia of<unk> . *Infection. *Injury such as a fracture. *Inflammatory bowel disease. *Juvenile idiopathic arthritis. *Legg–Calvé–Perthes disease. *Lyme disease, which is transmitted by ticks and is characterized by debilitating polyarthritis, neurologic symptoms, and erythema migrans. *Lymphoma. *Osteomalacia/rickets in adolescents. *Osteopetrosis. *Osteosarcoma. *Rickets. *Septic arthritis, a severe infection of the joint that can lead to permanent joint damage. *Spondyloarthropathies. *Viral diseases, including the measles, influenza, mononucleosis, chickenpox, and mumps. Common causes of<unk>  and joint pain in adults, such as osteoarthritis and gouty arthritis are rare in children, as these diseases are a sequelae of chronic wear and tear for several years. Cancer Pain caused by cancer within<unk> s is one of the most severe forms of pain. Because of its severity and uniqueness with respect to other forms of pain, it is extensively researched. According to studies of<unk>  cancer in mouse femur models, it has been determined that<unk>  related to cancer occurs as a result of destruction of<unk>  tissue. Chemical changes that occur within the spinal cord as a result of<unk>  destruction give further insight into the mechanism of<unk> . Metastatic cancer cells often establish themselves within the skeleton. When the cancer cells have metastasized, the mechanical dynamics of the<unk>  matrix become weaker as skeletal strength decreases. This leads to several other complications throughout the body, including pain, thus decreasing the patient's quality of life.<unk>  tumors are composed of a conglomeration of cell types, including cancer and immune system cells. Often, tumor cells secrete growth factors that activate receptors close to primary afferent neurons. Activation of these neural receptors is a contributing factor to pain sensation. Additionally, inflammatory lipids called prostaglandins, which are produced at high rates by cancer cells within tumors, activate nociceptors when they bind together.
Bone pain
Weather pains
Breast hypertrophy
Myalgia
Breast atrophy
Joint stiffness
Osteopathy
Dark skin