A<unk> . A<unk>  <unk> s) is a type of<unk>  predominantly found in germinal centers, containing many phagocytized, apoptotic cells in various states of degradation, referred to as<unk>  bodies<unk>  meaning stainable).<unk> s contain condensed chromatin fragments.<unk> s are licensed (empowered) for phagocytosis by follicular dendritic cells (FDCs). FDCs provide<unk> s with Milk fat globule-EGF factor 8 protein (Mfge8), which is a phosphatidylserine-binding "eat me" signal for removal of apoptotic germinal center B cells. It is thought that they may play a role in downregulating the germinal center reaction by the release of prostaglandins and hence a reduced B-cell induction of IL-2.<unk> s that contain debris from ingested lymphocytes are characteristic of a reactive follicular center in benign reactive lymphadenitis. Other accompanying signs of a benign follicular hyperplasia are well developed germinal centers with dark and light zones, in addition to numerous mitotic figures.
Tingible body macrophage
Reactive lymphocyte
Touton giant cell
Respirocyte
Intraepithelial lymphocyte
Langhans giant cell
Passenger leukocyte
Decoy cells