In humans<unk>  was originally made available for use in humans for the treatment of rheumatoid arthritis and gout in 1949. However, it is no longer approved, and therefore not marketed, for any human use in the United States. In the UK it is used to treat ankylosing spondylitis, but only when other therapies are unsuitable. In horses<unk>  is the most commonly used NSAID for horses in the United States. It is used for the following purposes: * Analgesia: It is used for pain relief from infections and musculoskeletal disorders, including sprains, overuse injuries, tendinitis, arthralgias, arthritis, and laminitis. Like other NSAIDs, it acts directly on musculoskeletal tissue to control inflammation, thereby reducing secondary inflammatory damage, alleviating pain, and restoring range of motion. It does not cure musculoskeletal ailments or work well on colic pain. * Antipyresis: It is used for reduction of fevers. Its antipyretic qualities may mask other symptoms. History of<unk>  in racing In the 1968 Kentucky Derby, Dancer's Image, the winner of the race, was disqualified after traces of<unk>  were allegedly discovered in a post-race urinalysis. Owned by prominent Massachusetts businessman Peter D. Fuller and ridden by jockey Bobby Ussery, Dancer's Image was the first horse to win the Kentucky Derby and then be disqualified.<unk>  was legal on most tracks around the United States in 1968, but had not yet been approved by Churchill Downs. Controversy and speculation still surround the incident. In the weeks prior to the race, Fuller had given previous winnings to Coretta Scott King, the widow of slain civil rights activist Martin Luther King Jr., which brought both praise and criticism. The previous year, King held a sit-in against housing discrimination which disrupted Derby week. Forty years later, Fuller still believed Dancer's Image was disqualified due to these events. Although Forward Pass had been named the winner, after many appeals the Kentucky Derby official website lists both Dancer's Image and Forward Pass as the winner. The website's race video commentary states that on the winner's plaque at Churchill Downs, both Dancer's Image and Forward Pass are listed as the 1968 winner of the Kentucky Derby. In dogs<unk>  is occasionally used in dogs for the longer-term management of chronic pain, particularly due to osteoarthritis. About 20% of adult dogs are affected with osteoarthritis, which makes the management of musculoskeletal pain a major component of companion animal practice. The margin of safety for all NSAIDs is narrow in the dog, and other NSAIDs are more commonly used (etodolac, and carprofen). Gastrointestinal-protectant drugs, such as misoprostol, cimetidine, omeprazole, ranitidine, or sucralfate, are frequently included as a part of treatment with any NSAID. Dogs receiving chronic<unk>  therapy should be followed with regular blood work and renal monitoring. Side effects of<unk>  in dogs include gastrointestinal (GI) ulceration, bone marrow depression, rashes, malaise, blood dyscrasias, and diminished renal blood flow.
Phenylbutazone
Metolazone
Flonicamid
Butylone
Tolbutamide
Bromfenac
Acebutolol
Iodixanol