The cause of POIS is unknown. Some doctors hypothesize that POIS is caused by an auto-immune reaction. Other doctors suspect a hormone imbalance as the cause. While other causes have been proposed as well, none of the proposed causes seem to fully explain the disease. Allergy hypothesis According to one hypothesis, "POIS is caused by Type-I and Type-IV allergy to the males' own semen". POIS could also be caused by an auto-immune reaction not to semen itself, but to another substance that is released during ejaculation, such as to cytokines. The allergy hypothesis has been disputed. According to one study, "IgE-mediated semen allergy in men may not be the potential mechanism of POIS". Hormone hypothesis According to another hypothesis, POIS is caused by a hormone imbalance, such as low progesterone, low cortisol, low testosterone, elevated prolactin, hypothyroidism, or low DHEA. POIS could be caused by a defect in neurosteroid precursor synthesis. In this case, the same treatment may not be effective for different sufferers. Different sufferers may have different missing precursors, ultimately leading to a deficiency of the same particular neurosteroid, causing similar symptoms. Withdrawal hypothesis It may be noted that the majority of POIS symptoms, including : flu-like symptoms, fatigue, muscle pains, sweating, mood disturbances, irritability, poor concentration and others are similarly caused during withdrawal from different drug classes and natural reinforcers. It's actually unknown if there could be a relationship between hypersexuality, pornography addiction, compulsive sexual behavior and POIS. Some evidence claims that POIS patients have a history of excessive masturbation in the early stage and it implicitly suggests that POIS could be a consequence of sex addiction. There is anecdotal evidence on porn addiction internet fora, that many men experience POIS like symptoms after ejaculation. Other possibilities POIS could also be caused by hyperglycemia or by chemical imbalances in the brain. Sexual activity for the first time may set the stage for an associated asthma attack or may aggravate pre-existing asthma. Intense emotional stimuli during sexual intercourse can lead to autonomic imbalance with parasympathetic over reactivity, thereby causing release of mast cell mediators that can provoke postcoital asthma and / or rhinitis in these patients. It is also possible that, in different individuals, the causes of POIS are different. POIS could represent "a spectrum of<unk> s of differing" causes. None of the currently proposed causes for POIS fully explain the connection between POIS and lifelong premature ejaculation.
Postorgasmic illness syndrome
Syndrome of subjective doubles
Functional somatic syndrome
Nociplastic pain
Feline hyperesthesia syndrome
Marasmus
Micturition syncope
Anorgasmia