<unk>  is the second most common metabolic<unk>  disorder, after osteoporosis. The overall prevalence and severity of<unk> 's disease are decreasing; the cause for these changes is unclear.<unk> 's disease is rare in people less than 55 years of age, and the prevalence increases with age. Evidence from studies of autopsy results have demonstrated<unk> 's disease in about 3 percent of people older than 40 years of age.<unk> 's disease is more common in males than females. Rates of<unk> 's disease are about 50 percent higher in men than in women. About 15 percent of people with<unk> 's disease also have a family member with the disease. In cases where the disease is familial, it is inherited in an autosomal dominant fashion, although not all people that inherit the affected version of the genes will express the disease (incomplete penetrance). The incidence of<unk> 's disease varies considerably with geographic location.<unk> 's predominantly affects people of European descent, whereas people of African, Asian, or Indian descent are less commonly affected.<unk> 's disease is less common in Switzerland and Scandinavia than in the rest of Western Europe.<unk> 's disease is uncommon in the native populations of North and South America, Africa, Asia, and the Middle East. When an individual from these regions does develop<unk> 's disease, there is typically some European ancestry present.
Paget's disease of bone
Diffuse idiopathic skeletal hyperostosis
Albright's hereditary osteodystrophy
Giant-cell tumor of bone
Fibrous dysplasia of bone
Tumoral calcinosis
Metabolic bone disease
Oncogenic osteomalacia