<unk> ecause water-soluble<unk>  are eliminated in the urine, taking large doses of certain<unk>  usually only produces transient side effects (only exception is pyridoxine). General side effects may include restlessness, nausea and insomnia. These side effects are almost always caused<unk> y dietary supplements and not foodstuffs.<unk> Tolerable Upper Intake Level (UL) Harmful effects<unk> unk> 1 None No known toxicity from oral intake. There are some reports of anaphylaxis caused<unk> y high-dose thiamin injections into the vein or muscle. However, the doses were greater than the quantity humans can physically absorb from oral intake.<unk> unk> 2 None No evidence of toxicity<unk> ased on limited human and animal studies. The only evidence of adverse effects associated with riboflavin comes from in vitro studies showing the production of reactive oxygen species (free radicals) when riboflavin was exposed to intense visible and UV light.<unk> unk> 3 US UL = 35 mg as a dietary supplement Intake of 3000 mg/day of nicotinamide and 1500 mg/day of nicotinic acid are associated with nausea, vomiting, and signs and symptoms of liver toxicity. Other effects may include glucose intolerance, and (reversible) ocular effects. Additionally, the nicotinic acid form may cause vasodilatory effects, also known as flushing, including redness of the skin, often accompanied<unk> y an itching, tingling, or mild<unk> urning sensation, which is also often accompanied<unk> y pruritus, headaches, and increased intracranial<unk> lood flow, and occasionally accompanied<unk> y pain. Medical practitioners prescribe recommended doses up to 2000 mg per day of niacin in either immediate-release or slow-release formats, to lower plasma triglycerides and low-density lipiprotein cholesterol.<unk> unk> 5 None No toxicity known.<unk> unk> 6 US UL = 100 mg/day; EU UL = 25 mg/day See Megavitamin-B6 syndrome for more information.<unk> unk> 7 None No toxicity known.<unk> unk> 9 1 mg/day Masks<unk> 12 deficiency, which can lead to permanent neurological damage.<unk> unk> 12 None established Skin and spinal lesions. Acne-like rash causality is not conclusively established.
B vitamins
Folate
Cholic acid
Omega-3 fatty acid
Zinc
Vitamin
Vitamin C and the Common Cold 
Niacin