Adverse effects by frequency Note: Potentially serious side effects are in bold. Very common (>10% frequency) * Lymphopenia * Hypophosphataemia * Haemorrhage * Hypertension * Diarrhea * Rash * Alopecia (hair loss; occurs in roughly 30% of patients receiving<unk>  * Hand-foot syndrome * Pruritus (itchiness) * Erythema * Increased amylase * Increased lipase * Fatigue * Pain * Nausea * Vomiting Common (1-10% frequency) * Leucopenia * Neutropoenia * Anaemia * Thrombocytopenia * Anorexia (weight loss) * Hypocalcaemia * Hypokalaemia * Depression * Peripheral sensory neuropathy * Tinnitus * Congestive heart failure * Myocardial infarction * Myocardial ischaemia * Hoarseness * Constipation * Stomatitis * Dyspepsia * Dysphagia * Dry skin * Exfoliative dermatitis * Acne * Skin desquamation * Arthralgia * Myalgia * Kidney failure * Proteinuria * Erectile dysfunction * Asthenia (weakness) * Fever * Influenza-like illness * Transient increase in transaminase Uncommon (0.1-1% frequency) * Folliculitis * Infection * Hypersensitivity reactions * Hypothyroidism * Hyperthyroidism * Hyponatraemia * Dehydration * Reversible posterior leukoencephalopathy * Hypertensive crisis * Rhinorrhoea * Interstitial lung disease-like events * Gastro-oesophageal reflux disease (GORD) * Pancreatitis * Gastritis * Gastrointestinal perforations * Increase in bilirubin leading, potentially, to jaundice * Cholecystitis * Cholangitis * Eczema * Erythema multiforme * Keratoacanthoma * Squamous cell carcinoma * Gynaecomastia (swelling of the breast tissue in men) * Transient increase in blood alkaline phosphatase * INR abnormal * Prothrombin level abnormal * bulbous skin reaction Rare (0.01-0.1% frequency) * QT interval prolongation * Angiooedema * Anaphylactic reaction * Hepatitis * Radiation recall dermatitis * Stevens–Johnson syndrome * Leucocytoclastic vasculitis * Toxic epidermal necrolysis * Nephrotic syndrome * Rhabdomyolysis
Sorafenib
Encorafenib
Regorafenib
Neratinib
Tucatinib
Capmatinib
Lapatinib
Dasatinib