The<unk> s <unk> , also known as second generation<unk> s (SGAs) and serotonin–dopamine antagonists (SDAs), are a group of<unk>  drugs<unk>  drugs in general are also known as major tranquilizers and neuroleptics, although the latter is usually reserved for the<unk> s) largely introduced after the 1970s and used to treat psychiatric conditions. Some<unk> s have received regulatory approval (e.g. by the FDA of the US, the TGA of Australia, the MHRA of the UK) for schizophrenia, bipolar disorder, irritability in autism, and as an adjunct in major depressive disorder. Both generations of medication tend to block receptors in the brain's dopamine pathways.<unk> s are less likely than haloperidol — the most widely used<unk>  — to cause extrapyramidal motor control disabilities in patients such as unsteady Parkinson's disease-type movements, body rigidity, and involuntary tremors. However, only a few of the<unk> s have been demonstrated to be superior to lesser-used, low-potency first-generation<unk> s in this regard. As experience with these agents has grown, several studies have questioned the utility of broadly characterizing<unk>  drugs as<unk> /second generation" as opposed to "first generation," noting that each agent has its own efficacy and side-effect profile. It has been argued that a more nuanced view in which the needs of individual patients are matched to the properties of individual drugs is more appropriate. Although<unk> s are thought to be safer than<unk> s, they still have severe side effects, including tardive dyskinesia (a serious movement disorder), neuroleptic malignant syndrome, and increased risk of stroke, sudden cardiac death, blood clots, and diabetes. Significant weight gain may occur. Critics have argued that "the time has come to abandon the terms first-generation and second-generation<unk> s, as they do not merit this distinction."
Atypical antipsychotic
Atypical antidepressant
Tricyclic antidepressant
Tetracyclic antidepressant
Heterocyclic antidepressant
Typical antipsychotic
Second-generation antidepressant
Antipsychotic