Despite its name (ending in -omycin)<unk>  is not a macrolide, but a member of a novel class of phosphonic antibiotics.<unk>  is bactericidal and inhibits bacterial cell wall biogenesis by inactivating the enzyme UDP-N-acetylglucosamine-3-enolpyruvyltransferase, also known as MurA. This enzyme catalyzes the committed step in peptidoglycan biosynthesis, namely the ligation of phosphoenolpyruvate (PEP) to the 3'-hydroxyl group of UDP-N-acetylglucosamine. This pyruvate moiety provides the linker that bridges the glycan and peptide portion of peptidoglycan.<unk>  is a PEP analog that inhibits MurA by alkylating an active site cysteine residue (Cys 115 in the Escherichia coli enzyme).<unk>  enters the bacterial cell through the glycerophosphate transporter.
Fosfomycin
Meropenem
Colistin
Ertapenem
Vancomycin
Resistin
Imipenem
Linezolid