<unk>  dysplasia is a mosaic disease resulting from post-zygotic activating mutations of the GNAS locus at 20q13.2-q13.3, which codes for the α subunit of the Gs G protein-coupled receptor. In bone, constitutive Gsα signaling results in impaired differentiation and proliferation of bone marrow stromal cells. Proliferation of these cells causes replacement of normal bone and marrow with<unk>  tissue. The bony trabeculae are abnormally thin and irregular, and often likened to Chinese characters (bony spicules on biopsy).<unk>  dysplasia is not hereditary, and there has never been a case of genetic inheritance from parent to child.
Fibrous dysplasia of bone
Fibrodysplasia ossificans progressiva
Osteofibrous dysplasia
Giant-cell tumor of bone
Osteoma cutis
Myositis ossificans
Diffuse idiopathic skeletal hyperostosis
Osteitis fibrosa cystica