<unk>  was found to bind to Htt in an N-terminal dependent manner, and co-localise with Htt in the CNS although the nature of this interaction with respect to was not identified. It has since been found that the CAG expansion seen with results in decreased binding affinity for<unk> , thus causing disruption of<unk> ’s usual function, and also an increase in free<unk> . It is likely that this decreased affinity plays a role in mediating HD pathogenesis, due to loss of cytoskeletal integrity and induction of apoptosis.<unk> ’s pro apoptotic effect may involve activation of caspase-8 and a novel<unk>  protein interactor HIPPI.<unk> ’s non-pathological activity includes clathrin assembly via interaction with clathrin light chains.<unk>  is the human homologue of Sla2p, a membrane protein in the periphery. Sla2p is an actin-binding protein involved in endocytosis, thus indicating<unk>  in this role. Further details suggesting an important role for<unk>  in endocytosis comes from binding studies looking at<unk>  binding to actin. Actin binding by<unk>  is altered depending on whether clathrin is also bound to<unk> .
Huntingtin-interacting protein 1
MSin3 interaction domain
Mothers against decapentaplegic homolog 4
Retinoblastoma protein
Zinc transporter 8
Mir-3180 microRNA precursor family
Mir-618 microRNA precursor family
Tetraspanin