Natural<unk>  was previously prescribed as gonadorelin hydrochloride (Factrel) and gonadorelin diacetate tetrahydrate (Cystorelin) for use in treating human diseases. Modifications of the decapeptide structure of<unk>  to increase half life have led to<unk> 1 analog medications that either stimulate <unk> 1 agonists) or suppress <unk>  antagonists) the gonadotropins. These synthetic analogs have replaced the natural hormone in clinical use. Its analogue leuprorelin is used for continuous infusion, to treat breast cancer, endometriosis, prostate cancer, and following research in the 1980s by researchers, including Dr. Florence Comite of Yale University, it was used to treat precocious puberty. A Cochrane Review is available which investigates whether<unk>  analogues, given before or alongside chemotherapy, could prevent damage to women's ovaries caused by chemotherapy.<unk>  agonists appear to be effective in protecting the ovaries during chemotherapy, in terms of menstruation recovery or maintenance, premature ovarian failure and ovulation.
Gonadotropin-releasing hormone
Menotropin
Counterregulatory hormone
Antigonadotropin
Prolactin-releasing peptide
Luteinizing hormone
Growth hormone–releasing hormone
Progonadotropin