<unk>  type 2 is often congenital (present at birth), as low birth weight is one of the first symptoms. Individuals with the condition have various bone abnormalities that affect the skeleton, head, and eyes. Most affected individuals also exhibit dwarfism, as the adult height often ranges from 48 to 59 inches. However, contrary to<unk> 1, individuals with<unk> 2 have normal intelligence levels. Various bones are affected by<unk> 2, as affected individuals often have thickened outer layers of long bones, and abnormally thin marrow cavities (medullary stenosis). Some individuals also exhibit the hardening of some bones (osteosclerosis). Additionally, individuals also have an abnormally large head circumference (macrocephaly) with a prominent forehead due to an abnormally large anterior fontanelle that closes late. Affected individuals may have unusually small eyes (microphthalmia), swelling of the optic disk due to leakage of cerebrospinal fluid (papilledema), and farsightedness. Hypocalcemia (low levels of calcium in the blood) is also common, usually occurring within two to three months after birth. This is due to the improper regulation of the parathyroid hormone (PTH) along with vitamin D and the hormone calcitonin, which regulates the calcium levels in the blood. The lack of PTH may be due to the improper function or absence of the parathyroid glands in individuals with<unk> 2. Symptoms often include weakness, muscle cramps, excessive nervousness, loss of memory, headaches, and abnormal sensations such as tingling and numbness of the hands. People affected by<unk> 1 have most of the above-mentioned abnormalities and symptoms. They may also exhibit liver disease during the first month of life, abnormally low levels of white blood cells, improper function of T-cells, intellectual disabilities, and/or underdeveloped, malformed nails.
Kenny-Caffey syndrome
Cohen syndrome
Cohen-Gibson syndrome
Gleich's syndrome
De Barsy syndrome
Foster Kennedy syndrome
Leschke syndrome
Fox–Fordyce disease