<unk> , also known as unfractionated<unk>  (UFH), is a medication and naturally occurring glycosaminoglycan. Since<unk> s depend on the activity of antithrombin, they are considered anticoagulants. Specifically it is also used in the treatment of heart attacks and unstable angina. It is given by injection into a vein or under the skin. Other uses include inside test tubes and kidney dialysis machines. Common side effects include bleeding, pain at the injection site, and low blood platelets. Serious side effects include<unk> -induced thrombocytopenia. Greater care is needed in those with poor kidney function.<unk>  is contraindicated for suspected cases of vaccine-induced pro-thrombotic immune thrombocytopenia (VIPIT) secondary to SARS-CoV-2 vaccination, as<unk>  may further increase the risk of bleeding in an anti-PF4/heparin complex autoimmune manner, in favor of alternative anticoagulant medications (such as argatroban or danaparoid).<unk>  appears to be relatively safe for use during pregnancy and breastfeeding.<unk>  is produced by basophils and mast cells in all mammals. The discovery of<unk>  was announced in 1916. It is on the World Health Organization's List of Essential Medicines. A fractionated version of<unk> , known as low molecular weight<unk> , is also available.
Heparin
Prokarin
Ticlopidine
Palladin
Argatroban
Lepirudin
Hirudin
Tissue plasminogen activator