Research has suggested that a two-step process is necessary for<unk>  binding and neutralizing: recognition of the epitope on gp41 and a hydrophobic interaction with the lipid membrane of the virus by the<unk>  CDR H3 loop. The structure of the antibody is such that it readily binds to a membrane-proximal epitope, unbothered by steric hindrance. It prevents infection by tightly binding to conserved structural regions and blocks membrane fusion by the HIV virus.<unk>  may also be able to activate the complement system and ADCC to kill infected cells.
2F5 antibody
ANA-12
C-ANCA
Anti-nuclear antibody
Anti-LKM antibody
Anti-neutrophil cytoplasmic antibody
Anti–Saccharomyces cerevisiae antibody
Anti–citrullinated protein antibody