<unk>  in oral, injectable, and suppository form<unk>  is a thymidine analogue.<unk>  works by selectively inhibiting HIV's reverse transcriptase, the enzyme that the virus uses to make a DNA copy of its RNA. Reverse transcription is necessary for production of HIV's double-stranded DNA, which would be subsequently integrated into the genetic material of the infected cell (where it is called a provirus). Cellular enzymes convert<unk>  into the effective 5'-triphosphate form. Studies have shown that the termination of HIV's forming DNA chains is the specific factor in the inhibitory effect. At very high doses,<unk> 's triphosphate form may also inhibit DNA polymerase used by human cells to undergo cell division, but regardless of dosage<unk>  has an approximately 100-fold greater affinity for HIV's reverse transcriptase. The selectivity has been suggested to be due to the cell's ability to quickly repair its own DNA chain if it is disrupted by<unk>  during its formation, whereas the HIV virus lacks that ability. Thus<unk>  inhibits HIV replication without affecting the function of uninfected cells. At sufficiently high dosages,<unk>  begins to inhibit the cellular DNA polymerase used by mitochondria to replicate, accounting for its potentially toxic but reversible effects on cardiac and skeletal muscles, causing myositis.
Zidovudine
Saquinavir
Fosamprenavir
Entecavir
Lamivudine
Indinavir
Coronavir
Abacavir