Whenever possible, the first-choice treatment of AMSF tumors is surgical resection with wide margins in order to remove all neoplastic tissue. This treatment can be curative particularly when all tumor is removed but recurrences have developed at the sites of their surgical removals in 22% to 67% of all cases. Repeated recurrences at a site are commonly treated with repeated surgical resections with some patients treated with several resections at a site. Amputations of an extremity may be considered when wide resection fails to preserve a functional lower extremity or when multiple resections are consistently followed by recurrences. Preoperative or postoperative radiation therapy may have a role in treating these tumors, especially in cases were surgical removal leaves tumor tissue behind. In a minority of cases (i.e. 1-2%), AMSF tumors metastasize to distant tissues. Radiation and chemotherapy either alone or in combination have been used to treat metastatic disease. While radiation therapy has been associated with improved local control, its overall efficacy has not been fully studied and remains unclear. The role of chemotherapy in the treatment of local and metastatic disease is also unclear.
Acral myxoinflammatory fibroblastic sarcoma
Superficial acral fibromyxoma
Peripheral ossifying fibroma
Juvenile hyaline fibromatosis
Aggressive infantile fibromatosis
Aggressive fibromatosis
Diffuse infantile fibromatosis
Juvenile active ossifying fibroma