<unk>  or maximal androgen<unk>  <unk>  or complete or combined androgen<unk>  (CAB) is a medical treatment involving the combination of both androgen receptor (AR) antagonism and inhibition or suppression of androgen production to attain maximal effectiveness in androgen deprivation therapy (ADT). An example of<unk>  is the combination of bicalutamide, an AR antagonist, with a gonadotropin-releasing hormone (GnRH) analogue such as leuprorelin or cetrorelix.<unk>  was developed for and is employed in the treatment of prostate cancer. Triple androgen<unk>  (TrAB) is a method of ADT in which a 5α-reductase inhibitor such as finasteride or dutasteride is added to CAB.<unk>  has been found to produce higher rates of gynecomastia (7 to 28%) than orchiectomy and GnRH analogues alone (1 to 16%), but lower rates than nonsteroidal antiandrogen monotherapy such as with bicalutamide (30 to 85%).
Maximum androgen blockade
Androgen suppression
Chemical castration
Steroidal aromatase inhibitor
Selective androgen receptor modulator
Antiandrogen
Steroidal antiandrogen
Selective estrogen receptor modulator