The onset of the disease is usually before age 2, but patients have been diagnosed with<unk>  even into adolescence. Of the three entities,<unk> -1 usually presents earliest. Patients usually present in early childhood with cholestasis, jaundice, and failure to thrive. Intense pruritus is characteristic; in patients who present in adolescence, it has been linked with suicide. Patients may have fat malabsorption, leading to fat soluble vitamin deficiency, and complications, including osteopenia.
Progressive familial intrahepatic cholestasis
Vanishing bile duct syndrome
Autoimmune hepatitis
Congenital hepatic fibrosis
Intrahepatic cholestasis of pregnancy
Familial cirrhosis
Alcoholic hepatitis
Neonatal cholestasis