<unk>  (PEM) is one of the main symptoms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). PEM is "a delayed and significant exacerbation of ME/CFS symptoms that always follows physical activity and often follows cognitive activity". PEM is considered a cardinal symptom by a number of the different diagnostic criteria for ME/CFS, including the International Consensus Criteria (ICC). The Canadian Consensus Criteria (CCC) does not consider PEM compulsory, rather it requires "post<unk><unk>  and/or post<unk>  fatigue". The National Academy of Medicine's (NAM) Systemic Exertion Intolerance Disease (SEID) criteria (also called IOM 2015 Diagnostic Criteria) requires PEM. The Centers for Disease Control and Prevention (CDC) use the SEID/IOM 2015 Diagnostic Criteria on its website's ME/CFS page and list PEM as a primary symptom.
Post-exertional malaise
Alcohol flush reaction
Exercise-associated muscle cramps
Cholinergic crisis
Post-acute-withdrawal syndrome
Exercise-induced nausea
Masked depression
Vasoplegic syndrome