Absolute * Any prior intracranial hemorrhage * Known structural cerebral vascular lesion (e.g., arteriovenous malformation) * Known cancer inside the<unk> ull (primary or metastatic) * Ischemic stroke more than 4.5 hours and less than 3 months ago * Suspected aortic dissection * Active bleeding or bleeding problem other than menstruation * Significant closed-head or facial trauma within 3 months * Intracranial or intraspinal surgery within 2 months * Severe uncontrolled high blood pressure (unresponsive to emergency therapy) * For<unk> , prior treatment within the previous 6 months Relative * History of chronic, severe, poorly controlled hypertension * Significant hypertension on presentation (SBP >180 mm Hg or DBP >110 mm Hg) * History of prior ischemic stroke more than 3 month ago * Dementia * Known intracranial pathology not covered in absolute contraindications * Traumatic or prolonged (>10 min) CPR * Major surgery less than three weeks ago * Recent (within 2 to 4 wk) internal bleeding * Noncompressible vascular punctures * Active peptic ulcer * Oral anticoagulant therapy
Streptokinase
Thrombin
Serpin
Fibrinolysin
Prothrombinase
Angiozyme
Ocriplasmin
Coagulase