<unk>  (DRESS), also termed<unk> -induced hypersensitivity syndrome (DIHS), is a rare<unk>  to certain medications. It involves primarily a widespread skin rash, fever, swollen lymph nodes, and characteristic blood abnormalities such as an abnormally high level of eosinophils, low number of platelets, and increased number of atypical white blood cells (lymphocytes). However, DRESS is often complicated by potentially life-threatening inflammation of internal organs and the syndrome has about a 10% mortality rate. Treatment consists of stopping the offending medication and providing supportive care.<unk>  corticosteroids are commonly used as well but no controlled clinical trials have assessed the efficacy of this treatment. DRESS is classified as one form of severe cutaneous adverse<unk> s (SCARs). In addition to DRESS, SCARs includes four other<unk> -induced skin<unk> s, the Stevens–Johnson syndrome (SJS); Toxic epidermal necrolysis (TEN), Stevens–Johnson/toxic epidermal necrolysis overlap syndrome (SJS/TEN); and Acute generalized exanthematous pustulosis (AGEP). The SCARs disorders have similar disease mechanisms. New strategies are in use or development to screen individuals at risk for DRESS to aid them in avoiding medications that increase the risk of DRESS. Alternative medications are used in all individuals testing positive for these predispositions. Prior to 1996, there were numerous reports on individuals presenting with a medication-induced disorder now recognized as the DRESS syndrome. For example, anticonvulsants in the 1930s, phenytoin in 1950, and other medications in the ensuing years were reported to do so. The reports often named the disorder based on the medication evoking it, e.g. the anticonvulsant hypersensitivity syndrome, allopurinol hypersensitivity syndrome, and dapsone hypersensitivity syndrome. In 1996, however, the term DRESS syndrome was coined in a report attempting to simplify the terminology and consolidate these various clearly related syndromes into a single underlying disorder.
Drug reaction with eosinophilia and systemic symptoms
Mast cell activation syndrome
Hypotrichosis–lymphedema–telangiectasia syndrome
Tropical eosinophilia
Leukotriene receptor antagonist-associated Churg–Strauss syndrome
Bare lymphocyte syndrome type II
Pitt–Hopkins syndrome
Papular purpuric gloves and socks syndrome