Symptoms can vary from person to person. Someone in early stage<unk>  disease may not feel sick or notice symptoms as they occur. When the<unk> s fail to filter properly, waste accumulates in the blood and the body, a condition called azotemia. Very low levels of azotaemia may produce few, if any, symptoms. If the disease progresses, symptoms become noticeable (if the failure is of sufficient degree to cause symptoms).<unk>  accompanied by noticeable symptoms is termed uraemia. Symptoms of<unk>  include the following: * High levels of urea in the blood, which can result in: * Vomiting or diarrhea (or both) that may lead to dehydration * Nausea * Weight loss * Nocturnal urination (nocturia) * More frequent urination, or in greater amounts than usual, with pale urine * Less frequent urination, or in smaller amounts than usual, with dark coloured urine * Blood in the urine * Pressure, or difficulty urinating * Unusual amounts of urination, usually in large quantities * A buildup of phosphates in the blood that diseased<unk> s cannot filter out may cause: * Itching * Bone damage * Nonunion in broken bones * Muscle cramps (caused by low levels of calcium which can be associated with hyperphosphatemia) * A buildup of potassium in the blood that diseased<unk> s cannot filter out (called hyperkalemia) may cause: * Abnormal heart rhythms * Muscle paralysis * Failure of<unk> s to remove excess fluid may cause: * Swelling of the hands, legs, ankles, feet, or face * Shortness of breath due to extra fluid on the lungs (may also be caused by anemia) * Polycystic<unk>  disease, which causes large, fluid-filled cysts on the<unk> s and sometimes the liver, can cause: * Pain in the back or side * Healthy<unk> s produce the hormone erythropoietin that stimulates the bone marrow to make oxygen-carrying red blood cells. As the<unk> s fail, they produce less erythropoietin, resulting in decreased production of red blood cells to replace the natural breakdown of old red blood cells. As a result, the blood carries less hemoglobin, a condition known as anemia. This can result in: * Feeling tired or weak * Memory problems * Difficulty concentrating * Dizziness * Low blood pressure * Normally proteins are too large to pass through the<unk> s. However they are able to pass through when the glomeruli are damaged. This does not cause symptoms until extensive<unk>  damage has occurred, after which symptoms include: * Foamy or bubbly urine * Swelling in the hands, feet, abdomen, and face * Other symptoms include: * Appetite loss, which may include a bad taste in the mouth * Difficulty sleeping * Darkening of the skin * Excess protein in the blood * With high doses of penicillin, people with<unk>  may experience seizures
Kidney failure
Heart failure
Liver failure
Hypermagnesemia
Pulmonary toxicity
Hepatotoxicity
Acute liver failure
Neurotoxicity