An<unk> , or<unk> , is a drug which opposes the actions of corticotropin-releasing hormone (CRH) and/or adrenocorticotropic hormone (ACTH) in relation to their stimulatory effects on the adrenal glands, or which otherwise suppresses steroid hormone production in the adrenal glands. They can be said to have<unk>  (or anticorticotrophic) effects, and are used to treat Cushing's syndrome, prostate cancer, hyperandrogenism, and other conditions. Some examples of<unk> s include the following: * Corticosteroids, including glucocorticoids and mineralocorticoids, which exert negative feedback on the hypothalamic–pituitary–adrenal axis to maintain homeostasis * High-dose estrogens and antiandrogens, which can partially suppress adrenal androgen production * Certain progestins such as megestrol acetate, medroxyprogesterone acetate, and cyproterone acetate, which likely work via their weak glucocorticoid activity Conversely, drugs that stimulate CRH and/or ACTH secretion and/or activate adrenal steroidogenesis, such as antiglucocorticoids like mifepristone, antimineralocorticoids like spironolactone, and adrenal steroidogenesis inhibitors like ketoconazole, metyrapone, mitotane, and aminoglutethimide, have corticotropic or procorticotropic effects.<unk> s are analogous to antigonadotropins and procorticotropins are analogous to progonadotropins.
Anticorticotropin
Orexin
Antigonadotropin
Menotropin
Xenohormone
Gonadotropin
Counterregulatory hormone
Testosterone