The<unk>  were 17 wild-born macaque<unk>  from the Philippines who were kept in the Institute for Behavioral Research in<unk><unk> , Maryland. From 1981 until 1991, they became what one writer called the most famous lab animals in history, as a result of a battle between animal researchers, animal advocates, politicians, and the courts over whether to use them in research or release them to a sanctuary. Within the scientific community, the<unk>  became known for their use in experiments into neuroplasticity—the ability of the adult primate brain to reorganize itself. The<unk>  had been used as research subjects by Edward Taub, a psychologist, who had cut afferent ganglia that supplied sensation to the brain from their arms, then used arm slings to restrain either the good or deafferented arm to train them to use the limbs they could not feel. In May 1981, Alex Pacheco of the animal-rights group People for the Ethical Treatment of Animals (PETA) began working undercover in the lab, and alerted police to what PETA viewed as unacceptable living conditions for the<unk> . In what was the first police raid in the U.S. against an animal researcher, police entered the Institute and removed the<unk> , charging Taub with 17 counts of animal cruelty and failing to provide adequate veterinary care. He was convicted on six counts; five were overturned during a second trial, and the final conviction was overturned on appeal in 1983, when the court ruled that Maryland's animal cruelty legislation did not apply to federally funded laboratories. The ensuing battle over the<unk> ' custody saw celebrities and politicians campaign for the<unk> ' release, an amendment in 1985 to the Animal Welfare Act, the transformation of PETA from a group of friends into a national movement, the creation of the first North American Animal Liberation Front cell, and the first animal research case to reach the United States Supreme Court. In July 1991, PETA's application to the Supreme Court for custody was rejected. Days later, the last two<unk>  were killed after veterinarians determined they were suffering and should be euthanized. During the subsequent dissection of the<unk> , it was discovered that significant cortical remapping had occurred, suggesting that being forced to use limbs with no sensory input had triggered changes in their brains' organization. This evidence of the brain's plasticity helped overturn the widely held view that the adult brain cannot reorganize itself in response to its environment. After five years of receiving death threats and being unable to find a research position, Taub was offered a grant by the University of Alabama, where he developed a new form of therapy, based on the concept of neuroplasticity, for people disabled as a result of brain damage. Known as constraint-induced movement therapy, it has helped stroke survivors regain the use of limbs paralysed for many years, and has been hailed by the American Stroke Association as being at the forefront of a revolution.
Silver Spring monkeys
Charley horse
Wellbee
Cold turkey
Pest house
Bowl of Hygieia
Nude mouse
White cane