<unk>  is associated with sepsis, particularly when accompanied by<unk>  granulation. The finding is also associated with bacterial infection, alcohol<unk> ity, liver failure, and treatment with granulocyte colony-stimulating factor, a cytokine drug used to increase the absolute neutrophil count in patients with neutropenia. The formation of<unk>  vacuoles represents increased phagocytic activity, which is stimulated by the release of cytokines in response to inflammation or tissue injury.<unk>  frequently occurs in conjunction with<unk>  granulation and Döhle bodies in inflammatory states, and these findings are collectively referred to as<unk>  changes. Neutrophilia and left shift (the presence of immature neutrophil precursors such as band neutrophils and metamyelocytes in the peripheral blood) often accompany<unk>  changes, as these phenomena also occur in response to inflammation. It has been suggested that neutrophil vacuoles not be labelled<unk>  vacuoles" unless they are accompanied by other<unk>  changes, as<unk>  can occur in other conditions.
Toxic vacuolation
Granulovacuolar degeneration
Feathery degeneration
Ballooning degeneration
Piecemeal necrosis
Necrobiosis
Collagenous spherulosis
Fasciolosis