Freckles are clusters of concentrated melaninized cells which are most easily visible on people with a fair complexion. Freckles do not have an increased number of the melanin-producing cells, or melanocytes, but instead have melanocytes that overproduce melanin granules (melanosomes) changing the coloration of the outer skin cells (keratinocytes). As such, freckles are different from lentigines and moles, which are caused by accumulation of melanocytes in a small area. Freckles can appear on all types of skin tones. Of the six Fitzpatrick skin types, they are most common on skin tones 1 and 2, which usually belong to North Europeans. However, it can be found in all ethnicities.
symptom of Xeroderma pigmentosum
symptom of Japanese encephalitis
symptom of Chilaiditi syndrome
symptom of Dermatomyositis
symptom of Maroteaux–Lamy syndrome
symptom of Stevens–Johnson syndrome
symptom of Rotor syndrome
symptom of Bannayan–Riley–Ruvalcaba syndrome