Individuals with<unk>  may develop chronic obstructive pulmonary disease (emphysema) during their thirties or forties even without a history of smoking, though smoking greatly increases the risk. Symptoms may include shortness of breath (on exertion and later at rest), wheezing, and sputum production. Symptoms may resemble recurrent respiratory infections or asthma.<unk>  may cause several manifestations associated with liver disease, which include impaired liver function and cirrhosis. In newborns,<unk>  can result in early onset jaundice followed by prolonged jaundice. Between 3% and 5% of children with ZZ mutations develop life-threatening liver disease, including liver failure.<unk>  is a leading reason for liver transplantation in newborns. In newborns and children,<unk>  may cause jaundice, poor feeding, poor weight gain, hepatomegaly and splenomegaly. Conditions associated with<unk> , occurring due to paucity of AAT in circulation allowing uninhibited inflammation in lungs, and accumulation of mutated AAT in the liver Apart from COPD and chronic liver disease, α1-antitrypsin<unk>  has been associated with necrotizing panniculitis (a skin condition) and with granulomatosis with polyangiitis in which inflammation of the blood vessels may affect a number of organs but predominantly the lungs and the kidneys.
Alpha-1 antitrypsin deficiency
Asthma
CHILD syndrome
Reactive airway disease
Mineral dust airway disease
Cystic fibrosis
Yokkaichi asthma
Upper airway resistance syndrome