<unk>  is a rare disorder that sometimes occurs in patients in about 15-25% of patients who have had both adrenal glands removed to treat Cushing's disease. In patients with pre-existing adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas, loss of adrenal feedback following bilateral adrenalectomy can trigger the rapid growth of the tumor, leading to visual symptoms (e.g. bitemporal hemianopsia) and hyperpigmentation. The severity of the disease is dependent upon the effect of ACTH release on the skin, pituitary hormone loss from mass compression, as well as invasion into surrounding structures around the pituitary gland. The first case of<unk>  was reported in 1958 by Dr. Don<unk> . Within the past ten to twenty years, improvements have been made with identification and care for patients with Cushing's disease. Techniques such as pituitary radiation therapy, ACTH assay, transsphenoidal pituitary surgery, higher resolution MRIs, and sampling of the inferior petrosal sinus have allowed physicians to pursue routes for Cushing's syndrome therapy prior to consideration of bilateral adrenalectomy.<unk>  is also referred to as post adrenalectomy syndrome, a possible result of adrenalectomy performed for Cushing's disease.
Nelson's syndrome
Mendelson's syndrome
Fowler's syndrome
Schwartz–Matsuo syndrome
Coffin–Lowry syndrome
Young–Simpson syndrome
Grisel's syndrome
Renpenning's syndrome