The disease is an uncontrolled proliferation of B cell lymphocytes latently infected with Epstein–Barr virus (EBV). Production of an interleukin-10, an endogenous, pro-regulatory cytokine, has also been implicated. In immunocompetent patients, Epstein-Barr virus can cause infectious mononucleosis in adolescents, which is otherwise asymptomatic in children during their childhood. However, in immunosuppressed<unk>  patients, the lack of T-cell immunosurveillance can lead to the proliferation of these EBV-infected B-lymphocytes. However, calcineurin inhibitors (tacrolimus and ciclosporin), used as immunosuppressants in organ<unk> ation inhibit T cell function, and can prevent the control of the B cell proliferation. Depletion of T cells by use of anti-T cell antibodies in the prevention or treatment of<unk>  rejection further increases the risk of developing<unk> . Such antibodies include ATG, ALG and OKT3 (muromonab-CD3). Polyclonal<unk>  may form tumor masses and present with symptoms due to a mass effect, e.g. symptoms of bowel obstruction. Monoclonal forms of<unk>  tend to form a disseminated malignant lymphoma.
Post-transplant lymphoproliferative disorder
AIDS-related lymphoma
Transfusion-associated graft-versus-host disease
Thymoma-associated multiorgan autoimmunity
Splenic marginal zone lymphoma
Graft-versus-host disease
Diffuse infiltrative lymphocytosis syndrome
Immune reconstitution inflammatory syndrome