An<unk>  is a drug which suppresses the activity and/or downstream effects of one or both of the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH). This results in an inhibition of the hypothalamic-pituitary-gonadal (HPG) axis, and thus a decrease in the levels of the androgen, estrogen, and progestogen sex steroids in the body.<unk> s also inhibit ovulation in women and spermatogenesis in men. They are used for a variety of purposes, including for the hormonal birth control, treatment of hormonally-sensitive cancers, to delay precocious puberty and puberty in transgender youth, as a form of chemical castration to reduce the sex drives of individuals with hypersexuality or pedophilia, and to treat estrogen-associated conditions in women such as menorrhagia and endometriosis, among others. High-dose<unk>  therapy has been referred to as medical castration. The best-known and widely used<unk> s are the gonadotropin-releasing hormone (GnRH) analogues (both agonists and antagonists). However, many other drugs have<unk>  properties as well, including compounds acting on sex steroid hormone receptors such as progestogens, androgens, and estrogens (due to negative feedback on the HPG axis), as well as steroid synthesis inhibitors such as danazol and gestrinone. Some<unk> s have a multimodal action, such as cyproterone acetate, which exerts its effects via acting as an antiandrogen, progestin, and steroid synthesis inhibitor. Since progestins have relatively little effect on sexual differentiation compared to the other sex steroids, potent ones such as medroxyprogesterone acetate and chlormadinone acetate are often used at high doses specifically for their<unk>  effects. Danazol, gestrinone, and paroxypropione have all been classified specifically as<unk> s.
Antigonadotropin
Menotropin
Progonadotropin
Gonadotropin
Luteinizing hormone
Anticorticotropin
Gonadorelin
Prolene