<unk>  is converted into isavuconazole inside the body, and isavuconazole is a substrate for CYP3A4 or CYP3A5. Many other medications inhibit or induce those two enzymes, and<unk>  should not be administered with them. Inducers result in levels of isavuconazole that are too low and won't work, and inhibitors can cause high levels of isavuconazole which will in turn cause increased adverse events and toxicity. Likewise<unk>  can interfere with appropriate dosing of other drugs that are substrates for those enzymes. In addition, isavuconazole induces CYP2B6 and can decrease the amount of drugs that are metabolized by the enzyme. Isavuconazole inhibits P-glycoprotein (P-gp), BCRP, SLC22A2, and uridine diphosphate-glucuronosyltransferases, each of which remove drugs from circulation;<unk>  will increase the amount of drugs that are affected by those proteins and may increase their toxicities.
Isavuconazonium
Lisocabtagene maraleucel
Suxamethonium chloride
Amylmetacresol
Cyfluthrin
Meconium
Pivhydrazine
Fomepizole