<unk>  is an antibiotic used to treat skin infections, external ear infections, infections of leg ulcers, diabetic foot infections, and infection of bone. Skin<unk>  is used for both staphylococcal and streptococcal skin infections. These include folliculitis, carbuncles, impetigo, ecthyma, cellulitis, erysipelas, necrotising fasciitis, and infections of skin conditions such as eczema, scabies, ulcers and acne. Due to the widespread belief that dual-therapy is needed to cover both Staphylococcus and Streptococcus in cellulitis,<unk>  is sometimes given with the addition of benzylpenicillin for more severe cellulitis. However, support for this practice has lessened since findings in a study published in the Emergency Medicine Journal in 2005 did not show this combination to give additional clinical benefit. In the UK, using<unk>  alone is the first choice for treating cellulitis. Some other countries vary. File:Impetigo2020.Impetigo File:Facial erysipelas.Erysipelas File:Folliculitis2.Folliculitis File:Cellulitis1.Cellulitis File:Carbuncle.Carbuncle Wounds Infections of leg ulcers can be treated with<unk> . With diabetic foot infections the dose is adjusted according to whether the infection appears mild, moderate or severe. Bone Despite having a lower than optimum drug penetration into bone ratio of 10-20%,<unk>  appears effective in treating osteomyelitis. Depending on local guidance it may be used in the treatment of infection of joints while waiting for culture results. Other It may be used in combination with other antibiotics to treat pneumonia and can be used to prevent infection before surgery, particularly heart, lung, or bone surgery. When used to treat endocarditis, in combination with other antibiotics or alone, the dose of<unk>  may need to exceed the usual dose. Resistance Despite<unk>  being insensitive to beta-lactamases, some organisms have developed resistance to it and other narrow-spectrum β-lactam antibiotics including methicillin. Such organisms include methicillin-resistant Staphylococcus aureus, which has developed resistance to<unk>  and other penicillins by having an altered penicillin-binding protein.
Flucloxacillin
Piperacillin
Cloxacillin
Dicloxacillin
Resistin
Vancomycin
Cefazolin
Spiramycin