The table in the multiple endocrine<unk>  article lists the genes involved in the various MEN syndromes. Most cases of<unk>  derive from a variation in the RET proto-oncogene, and are specific for cells of neural crest origin. A database of MEN-implicated RET mutations is maintained by the University of Utah Department of Physiology. The protein produced by the RET gene plays an important role in the TGF-beta (transforming growth factor beta) signaling system. Because the TGF-beta system operates in nervous tissues throughout the body, variations in the RET gene can have effects in nervous tissues throughout the body.<unk>  generally results from a gain-of-function variant of a RET gene. Other diseases, such as Hirschsprung disease, result from loss-of-function variants. OMIM # lists the syndromes associated with the RET gene.
Multiple endocrine neoplasia type 2
Multiple endocrine neoplasia type 1
Autoimmune polyendocrine syndrome type 1
Autoimmune polyendocrine syndrome type 2
Autoimmune polyendocrine syndrome type 3
McCune–Albright syndrome
Lightwood–Albright syndrome
Late onset congenital adrenal hyperplasia