<unk> , commonly known and marketed under the brand name Primacor, is a pulmonary vasodilator used in patients who have heart failure. It is a phosphodiesterase 3 inhibitor that works to increase the heart's contractility and decrease pulmonary vascular resistance.<unk>  also works to vasodilate which helps alleviate increased pressures (afterload) on the heart, thus improving its pumping action. While it has been used in people with heart failure for many years, studies suggest that<unk>  may exhibit some negative side effects that have caused some debate about its use clinically. Overall,<unk>  supports ventricular functioning of the heart by decreasing the degradation of cyclic adenosine monophosphate (cAMP) and thus increasing phosphorylation levels of many components in the heart that contribute to contractility and heart rate.<unk>  is used as a drug that causes positive ionotrophy and it will lead to an increased force of contraction.<unk>  use following cardiac surgery has been under some debate because of the potential increase risk of postoperative atrial arrhythmias. However, in the short term<unk>  has been deemed beneficial to those experiencing heart failure and an effective therapy to maintain heart function following cardiac surgeries. There is no evidence of any long term beneficial effects on survival. In critically ill patients with evidence of cardiac dysfunction there is limited good quality evidence to recommend its use.<unk>  is administered IV only and eliminated unchanged in the urine. Dose adjustment is required for patients with renal impairment.
Milrinone
Dobutamine
Adenosine
Esmolol
Digoxin
Captopril
Digitoxin
Miltefosine