<unk>  is a synthetic, non-peptide inhibitor of the interaction of fibrinogen with the integrin glycoprotein IIb/IIIa on human platelets. The Merck chemistry team of George Hartman, Melissa Egbertson and Wasyl Halczenko developed<unk>  from a lead compound discovered in focused screening of small molecule replacements of the key arginine-glycine-aspartic acid (Arg-Gly-Asp) subunit of fibrinogen. Computation of the distance between the charged Arg and Asp sites in fibrinogen provided guidance leading to directed screening success.<unk>  constitutes an antithrombotic, specifically an inhibitor of platelet aggregation.<unk>  is a modified version of a molecule found in the venom of the saw-scaled viper Echis carinatus.
Tirofiban
Tafamidis
Clopidogrel
Ticagrelor
Ticlopidine
Eptifibatide
Clofibride
Cetrorelix