Most patients with<unk>  show psychomotor retardation (i.e., delayed development of movement and coordination), corneal opacity, retinal degeneration and other ophthalmological abnormalities. Other symptoms include agenesis of the corpus callosum, iron deficiency resulting from an absence of acid secretion in the stomach, achlorhydria. Achlorhydria in these patients results in an increase in blood gastrin levels. These symptoms typically manifest early in life (within the first year). After disease onset there occurs a period of stability, typically lasting two to three decades during which very little disease progression occurs.
Mucolipidosis type IV
GM2-gangliosidosis, AB variant
GM1 gangliosidoses
Mucopolysaccharidosis type I
GM2 gangliosidoses
Glycogen storage disease type VI
Glycogen storage disease type V
Sphingolipidoses