This begins as infection is recognized by the body and macrophages begin walling off the microorganisms or pathogens. As macrophages release chemicals that digest cells, the cells begin to die. As the cells die they disintegrate but are not completely digested and the debris of the disintegrated cells clump together creating soft granular mass that has the appearance of cheese. As cell death begins, the granuloma forms and cell death continues the inflammatory response is mediated by a type IV hypersensitivity reaction. Some data suggests that the epithelioid morphology and associated barrier function of host macrophages associated with granulomas may prevent effective immune clearance of mycobacteria.
Caseous necrosis
Fat necrosis
Liquefactive necrosis
Coagulative necrosis
Xanthogranulomatous inflammation
Infibulation
Fibrosis
Feathery degeneration