Mechanism of action<unk>  inhibits bacterial cell-wall synthesis by binding to penicillin-binding proteins;<unk>  prevents renal metabolism of<unk> . Bioavailability Intramuscular injection: *<unk> : 60–75% *<unk> : 95–100% Distribution The drug is distributed rapidly and widely to most tissues and fluids, including sputum, pleural fluid, peritoneal fluid, interstitial fluid, bile, aqueous humor, reproductive organs, and bone; highest concentrations occur in pleural fluid, interstitial fluid, peritoneal fluid, and reproductive organs; low concentrations occur in CSF; it crosses the placenta, and enters breast milk Protein binding *<unk> : 13–21% *<unk> , 40% Metabolism<unk>  is metabolized in the kidney by dehydropeptidase 1; activity is blocked by<unk> . Elimination Half-life (both drugs): 60 min; prolonged with renal impairment. Excretion (both drugs): Urine (~70% as unchanged drug)
Imipenem/cilastatin
Fosfomycin/tobramycin
Ceftolozane/tazobactam
Ceftazidime/avibactam
Meropenem/vaborbactam
Colistin
Ampicillin/sulbactam
Resistin