alt=Torso of a young man with overlaid text of main side-effects of caffeine overdose. In moderate doses, caffeine is used to reduce physical fatigue, to prevent drowsiness and sleep, and to maintain and restore mental alertness and wakefulness. However, at higher doses, these stimulatory effects can become excessive and lead to a wide range of unpleasant symptoms including a dysphoric physical and mental state that is labeled<unk>  and is also known colloquially as "coffee nerves" or "caffeine jitters." These symptoms including nervousness, irritability, restlessness, insomnia, headaches, and palpitations after caffeine use.<unk>  usually occurs when consumption of caffeine reaches per day. For reference, a brewed 8oz (227ml) cup of coffee contains ~95 mg of caffeine (per USDA). According to the Diagnostic and Statistical Manual of Mental Disorders, caffeine overdose can result in a state of excessive stimulation of the central nervous system and the essential feature of Caffeine Intoxication is the recent consumption of caffeine. This diagnosis requires the presence of at least five signs or symptoms, from a list of 12, that develop during or shortly after caffeine use. This syndrome regularly happens when a person ingested large amounts of caffeine from any source (e.g., more than 400–500 mg at a time). The signs and symptoms are divided into one group that can appear after an intake of as little as 100 mg of caffeine (roughly the amount contained in a cup of brewed coffee) and another group of symptoms that appear at higher levels of intake (more than 1 g per day). Low-dose symptoms include #restlessness, #nervousness, #excitement, #insomnia, #flushed face, #diuresis (increased urination), and #gastrointestinal disturbance. Symptoms associated with high doses of caffeine include #muscle twitching, #rambling flow of thought and speech, #tachycardia and cardiac arrhythmia, #periods of inexhaustibility, and #psychomotor agitation, #anorexia (loss of appetite). The symptoms of caffeine intoxication are comparable to the symptoms of overdoses of other stimulants. In cases of much larger overdoses, mania, depression, lapses in judgment, disorientation, disinhibition, delusions, weight loss, loss of appetite, hallucinations, or psychosis may occur. Death can occur when a person had a caffeine overdose. The LD50 of caffeine in humans is dependent on individual sensitivity, but is estimated to be 150–200 milligrams per kilogram of body mass (75–100 cups of coffee for a 70 kilogram adult). A number of fatalities have been caused by overdoses of readily available powdered caffeine supplements, for which the estimated lethal amount is less than a tablespoon. The lethal dose is lower in individuals whose ability to metabolize caffeine is impaired due to genetics or chronic liver disease A death was reported in a man with liver cirrhosis who overdosed on caffeinated mints.<unk>  can also result in severe injury. In one case, energy drink<unk> , led to a severe brain hemorrhage and massive loss of brain matter.
Caffeinism
Cannabinoid hyperemesis syndrome
Nicotine poisoning
Sweating sickness
Theobromine poisoning
Caffeine dependence
Sleep apnea
Exercise addiction