<unk> , also known as all-trans retinoic acid (ATRA), is a medication used for the treatment of acne and acute promyelocytic leukemia. For acne, it is applied to the skin as a cream, gel or ointment. For leukemia, it is taken by mouth for up to three months. Topical<unk>  is also the most extensively investigated retinoid therapy for photoaging. Common side effects when used as a cream are limited to the skin and include skin redness, peeling, and sun sensitivity. When used by mouth, side effects include shortness of breath, headache, numbness, depression, skin dryness, itchiness, hair loss, vomiting, muscle pains, and vision changes. Other severe side effects include high white blood cell counts and blood clots. Use during pregnancy is contraindicated due to the risk of birth defects. It is in the retinoid family of medications.<unk>  was patented in 1957, and approved for medical use in 1962. It is on the World Health Organization's List of Essential Medicines.<unk>  is available as a generic medication. In 2019, it was the 244th most commonly prescribed medication in the United States, with more than 1million prescriptions.
Tretinoin
Alitretinoin
Isotretinoin
Clobetasol
Clobetasol propionate
Ulobetasol propionate
Urodilatin
Bexarotene