<unk>  is an oral analogue of lidocaine. It is a class IB antiarrhythmic which shorten the refractory period and action potential duration (APD). Decrease in APD more than that of ERP so there is increase ERP/APD ratio. The drug has a bioavailability of 90%, and peak plasma concentrations are seen after 2–4 hours. The mean drug half-life is approximately 11 hours.<unk>  is predominantly metabolised by the liver. The pharmacokinetics of<unk>  are preserved with even moderate to severe renal impairment, but dose adjustment may be required when creatinine clearance falls below 10 mL/minute.
Mexiletine
Verapamil
Metandienone
Tocainide
Riociguat
Amrinone
Ranolazine
Propranolol