* Natural decline of<unk><unk>  due to age. * Idiopathic. * Genetic factors, such as fragile x syndrome. Approximately 20–28% of women with an FMR1 premutation (55–200 CGG repeats) experience fragile x primary<unk>  insufficiency (POI) and another 23% experience early menopause (i.e., menopause before the age of forty five). * Autoimmune disorders. * Adrenal gland impairment. * Iatrogenic, e.g., due to radiation, chemotherapy or surgery, such as laserization of the surface of the ovary to treat endometriosis. Excessive laparoscopic<unk>  drilling has been reported to cause premature<unk>  failure. (The primordial follicles are located in the thin outer one-millimeter layer of the ovary.)
Poor ovarian reserve
Male pregnancy
Pregnancy
Lactational amenorrhea
Anovulation
Estrogen-dependent condition
Androgen-dependent condition
Antiestrogen withdrawal response