Properties of<unk> <unk> lar mass 285.338 g/mol Acidity (pKa) Step 1: 8.21 at 25 °C Step 2: 9.85 at 20 °C Solubility 0.15 g/L at 20 °C Melting point 255 °C Boiling point 190 °C sublimes A large overdose can cause asphyxia and death by respiratory depression if the person does not receive medical attention immediately. Overdose treatment includes the administration of naloxone. The latter completely reverses<unk> 's effects, but may result in immediate onset of withdrawal in opiate-addicted subjects.<unk> ltiple doses may be needed as the duration of action of<unk>  is longer than that of naloxone. The LD50 for humans of<unk>  sulphate and other preparations is not known with certainty. One poor quality study on<unk>  overdoses among soldiers reported that the fatal dose was 0.78 mcg/ml in males (~71 mg for an average 90 kg adult man) and 0.98mcg/ml in females (~74 mg for an average 75 kg female). It was not specified whether the dose was oral, parenteral or IV. Laboratory animal studies are usually cited in the literature. In serious drug dependency (high tolerance), 2000–3000 mg per day can be tolerated.
Morphine
Codeine
Nalorphine
Methadone
Isomethadone
Normethadone
Butorphanol
Fentanyl