+ Examples of<unk> s 150pxsumatriptan 150pxrizatriptan 150pxnaratriptan 150pxeletriptan 150pxdonitriptan 150pxalmotriptan 150pxfrovatriptan 150pxavitriptan 150pxzolmitriptan 150pxLY-334370 150pxL-694247 Migraine<unk> s are used for the treatment of severe migraine attacks or those that do not respond to NSAIDs or other over-the-counter drugs.<unk> s are a mid-line treatment suitable for many migraineurs with typical attacks. They may not work for atypical or unusually severe migraine attacks, transformed migraine, or status migrainosus (continuous migraine).<unk> s are highly effective, reducing the symptoms or aborting the attack within 30 to 90 minutes in 70–80% of patients. A test measuring a person's skin sensitivity during a migraine may indicate whether the individual will respond to treatment with<unk> s.<unk> s are most effective in those with no skin sensitivity; with skin sensitivity, it is best to take<unk> s within twenty minutes of the headache's onset. Oral rizatriptan and nasal zolmitriptan are the most used<unk> s for migraines in children. Correct timing of intake<unk> s should be taken as soon as possible after the onset of pain. In case of migraine with aura they are to be taken after the aura and with the onset of pain. If taken too early, they may not have the full effect on symptom reduction, and in case of an aura, they can worsen the aura. It is assumed that blood vessels are constricted during the aura phase and dilated during the pain phase, so a constrictive medication like a<unk>  is not recommended during the aura. Cluster headache<unk> s are effective for the treatment of cluster headache. This has been demonstrated for subcutaneous sumatriptan and intranasal zolmitriptan, the former of which is more effective according to a 2013 Cochrane review. Tablets were not considered appropriate in this review. Altitude sickness A single randomized controlled trial found that sumatriptan may be able to prevent altitude sickness. Available forms All marketed<unk> s are available in oral form; some in form of sublingual tablets. Sumatriptan and zolmitriptan are also available as nasal sprays. For sumatriptan, a number of other application forms are marketed: suppositories, a subcutaneous injection, an iontophoretic transdermal patch, which uses low voltage controlled by a pre-programmed microchip to deliver a single dose of sumatriptan through the skin within 30 minutes; a drug-device combination containing sumatriptan powder that is "breath powered" allowing the user to blow sumatriptan powder in to their nostrils; as well as a needle-free injection system that works with air pressure. +Formulations Tablet Oral disintegrating tablets Nasal spray Subcutaneous injection Rectal suppository all<unk> s rizatriptan sumatriptan sumatriptan sumatriptan zolmitriptan zolmitriptan
Triptan
Sumatriptan
Frovatriptan
Rizatriptan
Eletriptan
Almotriptan
Zolmitriptan
Naratriptan