The rate of omeprazole absorption is decreased by concomitant food intake. In addition, the absorption of lansoprazole and esomeprazole is decreased and delayed by food. It has been reported, however, that these pharmacokinetic effects have no significant impact on efficacy. PPIs have a half-life in human blood plasma of only 60–90 minutes, but because they covalently bind to the pump, the half-life of their inhibition of gastric acid secretion lasts an estimated 24 hours. Dissociation of the inhibitory complex is probably due to the effect of the endogenous antioxidant glutathione which leads to the release of omeprazole sulfide and reactivation of the enzyme.
medication of Gastroesophageal reflux disease
medication of Peptic ulcer disease
treatment of Gastritis
medication of Helicobacter pylori
medication of Gastrointestinal bleeding
medication of Hiatal hernia
treatment of Cardiovascular disease
symptom of Gastroesophageal reflux disease