A goitre can present as a palpable or visible enlargement of the thyroid gland at the base of the neck. A goitre, if associated with hypothyroidism or hyperthyroidism, may be present with symptoms of the underlying disorder. For hyperthyroidism, the most common symptoms are associated with adrenergic stimulation: tachycardia (increased heart rate), palpitations, nervousness, tremor, increased blood pressure and heat intolerance. Clinical manifestations are often related to hypermetabolism, (increased metabolism), excessive thyroid hormone, an increase in oxygen consumption, metabolic changes in protein metabolism, immunologic stimulation of diffuse goitre, and ocular changes (exophthalmos). Hypothyroid people commonly have poor appetite, cold intolerance, constipation, lethargy and may undergo weight gain. However, these symptoms are often non-specific and make diagnosis difficult. According to the WHO classification of goitre by palpation, the severity of goitre is currently graded as grade 0, grade 1, grade 2. File:Struma 001.Goitre Class I File:Kone med stor struma.Goitre Class II File:Goiter Kocher 1874.Goitre Class III
symptom of Hashimoto's thyroiditis
symptom of Graves' disease
symptom of Non-Hodgkin lymphoma
symptom of T-cell lymphoma
symptom of Type 1 diabetes
symptom of Hypothyroidism
symptom of Autoimmune disease
symptom of Herpes labialis