Mutations in the cathepsin C gene (CTSC), located at human chromosome 11q14.1-q14.3, are the cause of PLS. The disorder is inherited in an autosomal recessive manner. This means the defective gene responsible for the disorder is located on an autosome (chromosome 11 is an autosome), and two copies of the defective gene (one inherited from each parent) are required in order to be born with the disorder. The parents of an individual with an autosomal recessive disorder both carry one copy of the defective gene, but usually do not experience any signs or symptoms of the disorder.
Papillon–Lefèvre syndrome
Bogart–Bacall syndrome
Michels Caskey syndrome
Bonnet–Dechaume–Blanc syndrome
Jeavons syndrome
Peters-plus syndrome
Bowen–Conradi syndrome
Burnside–Butler syndrome