A patient presenting with hyper<unk>  syndrome may be affected by simple infectious organisms in exposed regions like the respiratory system. Vaccination against pathogenic organisms may not help these individuals, because vaccinating them does not properly stimulate production of antibodies. Symptoms can include: * Fever (recurrent infections) * Low counts of IgA, IgG and IgE antibodies * CD40L not reactive in T cells * Recurrent sinopulmonary and GI infections with pyogenic bacteria and opportunistic organisms, and cutaneous manifestations including pyodermas extensive warts.
Hyper-IgM syndrome type 1
Hyper-IgM syndrome type 5
Hyper-IgM syndrome type 2
Hyper-IgM syndrome type 3
Hyper-IgM syndrome type 4
Hyper IgM syndrome
Anti-IgLON5 disease
Wiskott–Aldrich syndrome