<unk>  <unk>  is a membrane protein and chloride channel in vertebrates that is encoded by the<unk>  gene. The<unk>  gene codes for an ABC transporter-class ion channel protein that conducts chloride ions across epithelial cell membranes. Mutations of the<unk>  gene affecting chloride ion channel function lead to dysregulation of epithelial fluid transport in the lung, pancreas and other organs, resulting in<unk><unk> . Complications include thickened mucus in the lungs with frequent respiratory infections, and pancreatic insufficiency giving rise to malnutrition and diabetes. These conditions lead to chronic disability and reduced life expectancy. In male patients, the progressive obstruction and destruction of the developing vas deferens (spermatic cord) and epididymis appear to result from abnormal intraluminal secretions, causing congenital absence of the vas deferens and male infertility.
Cystic fibrosis transmembrane conductance regulator
Growth hormone secretagogue receptor
Band 3 anion transport protein
Heart-type fatty acid binding protein
Zinc transporter 8
Low-density lipoprotein receptor gene family
LDL receptor
Xenobiotic-sensing receptor