<unk> is a medication used to treat and prevent bleeding in people with hemophilia A and other causes of low<unk>  Certain preparations may also be used in those with von Willebrand's disease. It is given by slow injection into a vein. Side effects include skin flushing, shortness of breath, fever, and red blood cell breakdown. Allergic reactions including anaphylaxis may occur. It is unclear if use during pregnancy is safe for the baby. A purified<unk> concentrate is made from human blood plasma. A recombinant version is also available. People may develop antibodies to<unk> such that this medication becomes less effective.<unk> was first identified in the 1940s and became available as a medication in the 1960s. Recombinant<unk> was first made in 1984 and approved for medical use in the United States in 1992. It is on the World Health Organization's List of Essential Medicines.
Factor VIII 
Factor IX
Factor XI
Thrombin
Prothrombinase
Von Willebrand factor
Fibrinogen
Platelet-activating factor