<unk>  can be diagnosed by prenatal MRI. MRI is better than ultrasound when it comes to detecting<unk>  or MSGP prenatally. The ideal time for proper prenatal diagnosis is between the 34th and 35th gestational week which is the time when the secondary gyration normally terminates. In<unk>  cases, the primary sulci would be unusually wide and flat while secondary sulci would be missing. At birth, lissencephaly with a head circumference of less than minus three standard deviations ( 3 mm) and is usually associated with other congenital anomalies. Microcephaly with a simplified gyral pattern has too few sulci and normal cortical thickness (3 mm) and is usually an isolated anomaly. +<unk>  and microcephaly with simplified gyral pattern<unk>  MSGP Mode of inheritance (if genetic) Autosomal recessive Cortical thickness thickened (>3 mm) normal (3 mm) Cortical surface smooth too few sulci Severity Severe form Mild form Associated anomalies? usually present not present (MSGP is usually isolated)
Microlissencephaly
Microhydranencephaly
Schizencephaly
Hemihydranencephaly
Lissencephaly
Holoprosencephaly
Hydranencephaly
Megalencephaly