Classification<unk>  can be divided into three distinct forms: infantile, juvenile, and adult. Out of all of these the infantile form is the most clinically relevant because it leads to developmental delay and adrenal insufficiency. * The infantile form is referred to as complex<unk>  because the defect in the gene for the<unk>  kinase enzyme is interconnected with defects in one or both of its affected genes that are responsible for Duchenne muscular dystrophy and adrenal hypoplasia congenita. The cause of this form is deletion of the Xp21 gene on the X chromosome. Patients have increased levels of serum creatine phosphokinase, which leads to myopathic changes in muscle biopsies resembling Duchenne muscular dystrophy. *The juvenile form does not show myopathy and patients have normal adrenal function. The main cause leading to this form of<unk>  is isolated enzyme deficiency. *The adult form is also caused by an isolated enzyme deficiency. Patients having this form of the disorder are clinically normal.
Glycerol kinase deficiency
2,4 Dienoyl-CoA reductase deficiency
Holocarboxylase synthetase deficiency
Dolichol kinase deficiency
Mevalonate kinase deficiency
Enolase deficiency
Malonyl-CoA decarboxylase deficiency
Acyl-CoA oxidase deficiency