<unk> , a phenothiazine derivative, is structurally different from the neuroleptic phenothiazines, with similar but different effects. It acts primarily as a strong antagonist of the H1 receptor (antihistamine) and a moderate mACh receptor antagonist (anticholinergic), and also has weak to moderate affinity for the 5-HT2A, 5-HT2C, D2,and α1-adrenergic receptors, where it acts as an antagonist at all sites, as well. New studies have shown that<unk>  acts as a strong non-competetive selective NMDA receptor antagonist; which might promote sedation in addition with the strong antihistaminergic effects of the H1 receptor, but also as a weaker analgesic. It does not however affect the AMPA receptors. Another notable use of<unk>  is as a local anesthetic, by blockade of sodium channels. Chemistry Solid<unk>  hydrochloride is a white to faint-yellow, practically odorless, crystalline powder. Slow oxidation may occur upon prolonged exposure to air, usually causing blue discoloration. Its hydrochloride salt is freely soluble in water and somewhat soluble in alcohol.<unk>  is a chiral compound, occurring as a mixture of enantiomers.
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