<unk>  is a ‘search-and-replace’ genome editing technology in molecular biology by which the genome of living organisms may be modified. The technology directly writes new genetic information into a targeted DNA site. It uses a fusion protein, consisting of a catalytically impaired Cas9 endonuclease fused to an engineered reverse transcriptase enzyme, and a<unk>  guide RNA (pegRNA), capable of identifying the target site and providing the new genetic information to replace the target DNA nucleotides. It mediates targeted insertions, deletions, and base-to-base conversions without the need for double strand breaks (DSBs) or donor DNA templates. The technology is an early-stage, experimental genome editing method that has received mainstream press attention due to its potential uses in medical genetics. It utilizes similar methodologies to precursor genome editing technologies, including CRISPR/Cas9 and base editors.<unk>  has been used to treat some animal models of genetic disease.
Prime editing
Hair cloning
Genome editing
Nucleotide salvage
Osseoincorporation
Somatic hypermutation
Mutanome
Exon shuffling