Arsenite impairs nucleotide excision repair, and it may also affect gene expression by increasing or decreasing DNA methylation. The high affinity of arsenic for sulfhydryl groups makes keratin-rich cells (e.g., epidermal keratinocytes) a sensitive target for arsenic-induced toxicity. Arsenic has been shown to alter epidermal keratinocyte differentiation processes, induce overexpression of growth factors, and enhance proliferation of human keratinocytes.
Arsenical keratosis
Reactional keratosis
Hydrocarbon keratosis
PUVA keratosis
Smokeless tobacco keratosis
Actinic keratosis
Waxy keratosis of childhood
Seborrheic keratosis