Perinuclear<unk>  of epidermal keratinocytes (one indicated by arrows), in this case an insignificant incidental finding. alt=Ameloblastoma;Subnuclear<unk>  in palisading cell - vacuoles at the basement membrane aspect, resembling a brighter stripe in the periphery of palisades.<unk>  is the formation of vacuoles or vacuole-like structures, within or adjacent to cells. Perinuclear<unk>  of epidermal keratinocytes is most likely inconsequential when not observed in combination with other pathologic findings. In dermatopathology<unk> " often refers specifically to vacuoles in the basal cell-basement membrane zone area, where it is an unspecific sign of disease. It may be a sign of for example vacuolar interface dermatitis, which in turn has many causes. It is one of the components of koilocytosis, which may be present in potentially pre-cancerous cervical, oral and anal lesions.
Vacuolization
Comedo extraction
Helmet removal 
Maggot therapy
Cauterization
Laser coagulation
Global distillation
Mucosectomy