<unk>  is the translocation of<unk> tic material between the<unk> <unk>  located on the short arm (designated p) of chromosome 12 at position p13.2 (i.e. 12p13.2) and the<unk> <unk>  located on the long arm (designated q) of chromosome 15 at position q25.3 (i.e. 15q25.3) to create the (12;15)(p13;q25)<unk> <unk> ,<unk><unk> . This new<unk>  consists of the 5' end of<unk>  fused to the 3' end of<unk> .<unk><unk>  therefore codes for a chimeric oncoprotein consisting of the helix-loop-helix (HLH) protein dimerization domain of the<unk>  protein fused to the tyrosine kinase (i.e. PTK) domain of the<unk>  protein. The<unk> <unk>  codes for the transcription factor protein,<unk> , which suppresses the expression of, and thereby regulates, various<unk> s that in mice are required for normal hematopoiesis as well as the development and maintenance of the vascular network.<unk>  codes for Tropomyosin receptor kinase C a NT-3 growth factor receptor cell surface protein that when bound to its growth factor ligand, neurotrophin-3, becomes an active tyrosine kinase that phosphorylates tyrosine residues on, and thereby stimulates, signaling proteins that promote the growth, survival, and proliferation of their parent cells. The tyrosine kinase of the<unk><unk><unk>  protein is dysfunctional in that it is continuously active in phosphorylating tyrosine residues on, and thereby continuously stimulating, proteins that promote the growth, survival, and proliferation of their parent cells. In consequence, these cells take on malignant characteristics and are on the pathway of becoming cancerous. Indeed, the<unk><unk><unk> <unk>  appears to be a critical driver of several types of cancers. It was originally identified in congenital fibrosarcoma and subsequently found in secretory breast cancer (also termed juvenile breast cancer), Mammary analogue secretory carcinoma of salivary glands (also termed MASC or MASCSG), congenital fibrosarcoma, congenital mesoblastic nephroma, rare cases of acute myelogenous leukemia, ALK-negative Inflammatory myofibroblastic tumour, cholangiocarcinoma, and radiation-induced papillary thyroid carcinoma.
ETV6-NTRK3 gene fusion
Tbx18 transduction
CDK13-related disorder
RAS-associated autoimmune leukoproliferative disorder
Oncogene addiction
Autoimmune GFAP astrocytopathy
Chromosomal translocation
Janus kinase 3 deficiency