Microphotograph of a macrophage that has phagocytized a lymphocyte<unk> . May Grünwald Giemsa stain. An<unk>  (Lupus Erythematosus cell), also known as Hargraves cell, is a neutrophil or macrophage that has phagocytized (engulfed) the denatured nuclear material of another cell. The denatured material is an absorbed hematoxylin body (also called an<unk>  body). They are a characteristic of lupus erythematosus, but also found in similar connective tissue disorders or some autoimmune diseases like in severe rheumatoid arthritis.<unk> s can be observed in drug-induced lupus, for example, following treatment with methyldopa. The<unk>  was discovered in bone marrow in 1948 by Malcolm McCallum Hargraves (1903–1982), a Physician and Practicing Histologist at the Mayo Clinic. Hargraves may have gained priority by suppressing a publication draft of John R. Haserick, who credits Dr. Dorothy Sundberg, chief hematologist at the University of Minnesota Hospitals, with first identifying<unk> s. Classically, the<unk>  is analyzed microscopically, but it is also possible to investigate this phenomenon by flow cytometry.<unk> s shouldn't be confused with Tart cells which have engulfed nuclear material, but with a visible chromatin rather than homogeneous appearance.
LE cell
Nurse cell
Clue cell
Echinocyte
Complex cell
Elliptocyte
Trophoblast
G cell