Pharmacokinetic analysis of plasma samples showed a rapid formation of<unk> ; concentrations generally exceeded those of<unk>  during ongoing infusion.<unk>  rapidly disappeared from plasma after infusion, while<unk>  typically peaked a few minutes after the end of infusion. This suggests that<unk>  is rapidly and widely distributed to extravasal tissues, in which<unk>  is formed and thereafter redistributed to plasma. This rapid disappearance from plasma is likely due to hydrolytic enzymes. The Zn(2+) dependent ectopeptidase (also known as alanine aminopeptidase), degrades proteins and peptides with a N-terminal neutral amino acid. Aminopeptidase N is frequently overexpressed in tumors and has been associated with the growth of different human cancers suggesting it as a suitable target for anti-cancerous therapy.
Melphalan flufenamide
Normustine
Ifosfamide
Fluorouracil
Carmustine
GemOx
Topotecan
Etoposide