A one gram ampoule of<unk> <unk>  is frequently used following major trauma.<unk>  is used to prevent and treat blood loss in a variety of situations, such as dental procedures, heavy menstrual bleeding, and surgeries with high risk of blood loss. Trauma<unk>  has been found to decrease the risk of death in people who have significant bleeding due to trauma. Its main benefit is if<unk> ken within the first three hours. It has been shown to reduce death due to any cause and death due to bleeding. Further studies are assessing the effect of<unk>  in isolated brain injury. Given within three hours of a head injury it also decreases the risk of death. Menstrual bleeding<unk>  is sometimes used to treat heavy menstrual bleeding. When<unk> ken by mouth it both safely and effectively treats regularly occurring heavy menstrual bleeding and improves quality of life. Another study demonstrated that the dose does not need to be adjusted in females who are between ages 12 and 16. Childbirth<unk>  is sometimes used (often in conjunction with oxytocin) to reduce bleeding after childbirth. Death due to postpartum bleeding was reduced in women receiving<unk> . Surgery *<unk>  is sometimes used in orthopedic surgery to reduce blood loss, to the extent of reducing or altogether abolishing the need for perioperative blood transfusion. It is of proven value in clearing the field of surgery and reducing blood loss when given before or after surgery. Drain and number of transfusions are reduced. * In surgical corrections of craniosynostosis in children it reduces the need for blood transfusions. * In spinal surgery (e.g., scoliosis), correction with posterior spinal fusion using instrumentation, to prevent excessive blood loss. * In cardiac surgery, both with and without cardiopulmonary bypass (e.g., coronary artery bypass surgery), it is used to prevent excessive blood loss. Dentistry In the United States,<unk>  is FDA approved for short-term use in people with severe bleeding disorders who are about to have dental surgery.<unk>  is used for a short period of time before and after the surgery to prevent major blood loss and decrease the need for blood transfusions.<unk>  is used in dentistry in the form of a 5% mouth rinse after extractions or surgery in patients with prolonged bleeding time; e.g., from acquired or inherited disorders. Hematology There is not enough evidence to support the routine use of<unk>  to prevent bleeding in people with blood cancers. However, there are several trials that are currently assessing this use of<unk> . For people with inherited bleeding disorders (e.g. von Willebrand's disease),<unk>  is often given. It has also been recommended for people with acquired bleeding disorders (e.g., directly acting oral anticoagulants (DOACs)) to treat serious bleeding. Nosebleeds The use of<unk> , applied directly to the area that is bleeding or<unk> ken by mouth, appears useful to treat nose bleeding compared to packing the nose with cotton pledgets alone. It decreases the risk of rebleeding within 10 days. Other uses * Tentative evidence supports the use of<unk>  in hemoptysis. * In hereditary angioedema * In hereditary hemorrhagic telangiectasia -<unk>  has been shown to reduce frequency of epistaxis in patients suffering severe and frequent nosebleed episodes from hereditary hemorrhagic telangiectasia. * In melasma -<unk>  is sometimes used in skin whitening as a topical agent, injected into a lesion, or<unk> ken by mouth, both alone and as an adjunct to laser therapy; as of 2017 its safety seemed reasonable but its efficacy for this purpose was uncertain because there had been no large scale randomized controlled studies nor long term follow-up studies. * In hyphema -<unk>  has been shown to be effective in reducing risk of secondary hemorrhage outcomes in people with traumatic hyphema. Experimental uses<unk>  might alleviate neuroinflammation in some experimental settings.<unk>  can be used in case of postpartum hemorrhage; it can decrease the risk of death due to bleeding by one third according to the WHO.
Tranexamic acid
Platelet-rich plasma
Flufenamic acid
Heparin
Hirudin
Palladin
Celadrin 
Tinzaparin sodium