The main pharmacological effects of<unk>  are the enhancement of GABA, an inhibitory neurotransmitter, at various GABA receptors. While 80% of<unk>  that is taken orally is absorbed, bioavailability in suppository form is closer to 50%.<unk>  has a long half-life of 18–26 hours, which means that<unk> 's effects after nighttime administration persist throughout the next day. This is due to the production of active metabolites. These metabolites further increase the duration of drug action compared to benzodiazepines that produce nonactive metabolites.<unk>  is lipophilic and is metabolised by the liver via oxidative pathways. The enzyme CYP3A4 is the main enzyme in its phase 1 metabolism in human liver microsomes.
Flunitrazepam
Flutoprazepam
Halazepam
Triazolam
Medazepam
Remimazolam
Amfepramone
Estazolam