MPFD is very rare. Incidence is estimated to be around 0.028%, or around 1 in 3,500 pregnancies. It may account for 12% of pregnancies where foetal growth is restricted. It shares symptoms with maternal floor infarction. In mothers who have already experienced it, there is a high risk of recurrence. Recurrence may be around 18%, although in cases where miscarriage occur in the first trimester, it may be as high as 50%.
Massive perivillous fibrin deposition
Collagenous spherulosis
Nodular vasculitis
Cerebroretinal microangiopathy with calcifications and cysts
Reactive perforating collagenosis
Platelet-rich fibrin matrix
Granulovacuolar degeneration
Palisaded neutrophilic and granulomatous dermatitis