<unk> , or SLONM, is a very rare disease, one of the<unk>  myopathies, causing loss of muscle bulk and weakness in the legs but sparing the cranial nerves, and beginning its clinical course after age 40. It was first identified in 1966 at the Mayo Clinic, by A.G. Engel, and that same year W.K. Engel and J.S. Resnick noted another case that they elaborated in 1975. The diagnosis of the disease rests on subacutely evolving weakness after age 40, normal to low CK level, a myopathic EMG with fibrillations, and often a monoclonal gammopathy. The diagnosis is confirmed by visualizing rods in cryosections on light and electron microscopy. The associated monoclonal gammopathy has an unfavorable prognosis.
Sporadic late-onset nemaline myopathy
Hereditary motor and sensory neuropathy with proximal dominance
Acquired non-inflammatory myopathy
Desmin-related myofibrillar myopathy
Myopathy, X-linked, with excessive autophagy
Statin-associated autoimmune myopathy
Lethal arthrogryposis with anterior horn cell disease
Thyrotoxic myopathy