Also like cyclosporin, it has a wide range of interactions.<unk>  is primarily metabolised by the cytochrome P450 system of liver enzymes, and there are many substances that interact with this system and induce or inhibit the system's metabolic activity. Interactions include that with grapefruit which increases<unk>  plasma concentrations. As infections are a major cause of morbidity and mortality in the post-transplant patient, the most commonly reported interactions include interactions with anti-microbial drugs.<unk> lide antibiotics including erythromycin and clarithromycin, as well as several of the newer classes of antifungals, especially of the azole class (fluconazole, voriconazole), increase<unk>  levels by competing for cytochrome enzymes.
Tacrolimus
Sirolimus
Temsirolimus
Pimecrolimus
Ruxolitinib
Rituximab
Tofacitinib
Ropeginterferon alfa-2b