Biologic protein Binding affinity (KinM) Notes 5-HT1A 280 5-HT1B 60 5-HT1D 96 5-HT1E 430 5-HT1F 360 5-HT2A 0.39 The receptor believed to mediate the atypicality of atypical antipsychotics. 5-HT2C 0.9 Likely responsible for its propensity for causing weight gain. 5-HT6 5.4 5-HT7 28 α1A 1.8 Likely responsible for the orthostatic hypotension seen in patients on<unk> . α2A 640 α2B 450 α2C 450 β1 5000 β2 5000 M1 >10000 M3 2692 D2 2.35 Believed to be responsible for the drug's efficacy against positive symptoms. D3 2.30 D4 4.92 hERG 3 Responsible for the QT interval prolongation and torsade de pointes H1 130 NK1 1000<unk>  is metabolized in the body to dehydrosertindole.
Sertindole
Iprindole
Pirlindole
Butriptyline
Bromocriptine
Influenzanet
Haloperidol
Ropinirole