<unk> , sold under the brand names Roxicodone and OxyContin (which is the extended release form) among others, is a semi-synthetic opioid medication used for treatment of moderate to severe pain. It is highly addictive and a common drug of abuse. It is usually taken by mouth, and is available in immediate-release and controlled-release formulations. Onset of pain relief typically begins within fifteen minutes and lasts for up to six hours with the immediate-release formulation. In the United Kingdom, it is available by injection. Combination products are also available with paracetamol (acetaminophen), ibuprofen, naloxone, naltrexone, and aspirin. Common side effects include euphoria, constipation, nausea, vomiting, loss of appetite, drowsiness, dizziness, itching, dry mouth, and sweating. Severe side effects may include addiction and dependence, substance abuse, irritability, depression or mania, delirium, hallucinations, hypoventilation, gastroparesis, bradycardia, and hypotension. Those allergic to codeine may also be allergic to<unk> . Use of<unk>  in early pregnancy appears relatively safe. Opioid withdrawal may occur if rapidly stopped.<unk>  acts by activating the μ-opioid receptor. When taken by mouth, it has roughly 1.5 times the effect of the equivalent amount of morphine.<unk>  was first made in Germany in 1916 from thebaine. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. In 2019, it was the 49th most commonly prescribed medication in the United States, with more than 14million prescriptions. A number of abuse-deterrent formulations are available, such as in combination with naloxone or naltrexone.
Oxycodone
Hydrocodone
Codeine
Morphine
Noroxycodone
Norhydrocodone
Tramadol
Piperoxan