Possible causes include: * Neoplasm * Carbohydrate malabsorption * Pancreatic cancer * Polycystic ovary syndrome (PCOS) * Trans fats Link to obesity Since<unk>  and obesity are so closely linked it is hard to determine whether<unk>  causes obesity or obesity causes<unk> , or both. Obesity is characterized by an excess of adipose tissue – insulin increases the synthesis of fatty acids from glucose, facilitates the entry of glucose into adipocytes and inhibits breakdown of fat in adipocytes. On the other hand, adipose tissue is known to secrete various metabolites, hormones and cytokines that may play a role in causing<unk> . Specifically cytokines secreted by adipose tissue directly affect the insulin signalling cascade, and thus insulin secretion. Adiponectins are cytokines that are inversely related to percent body fat; that is people with a low body fat will have higher concentrations of adiponectins where as people with high body fat will have lower concentrations of adiponectins. In 2011, it was reported that<unk>  is strongly associated with low adiponectin concentrations in obese people, though whether low adiponectin has a causal role in<unk>  remains to be established. * May lead to hypoglycemia or diabetes * Increased risk of PCOS * Increased synthesis of VLDL (hypertriglyceridemia) * Hypertension (insulin increases sodium retention by the renal tubules) * Coronary Artery Disease (increased insulin damages endothelial cells) * Increased risk of cardiovascular disease * Weight gain and lethargy (possibly connected to an underactive thyroid) * Obesity and<unk>  have some links with some types of cancer
Hyperinsulinemia
Hyperproinsulinemia
Oxyhyperglycemia
Hypoglycemia
Hyperinsulinism
Glycemia
Hyperprolactinaemia
Hyperinsulinemic hypoglycemia