Due to its non-selective inhibition of cytochrome P450 enzymes,<unk>  has numerous drug interactions. Examples of specific interactions include the following: *<unk>  affects the metabolism of methadone, sometimes resulting in higher blood levels and a higher incidence of side effects, and may interact with the antimalarial medication hydroxychloroquine. *<unk>  can also interact with a number of psychoactive medications, including tricyclic antidepressants and selective serotonin reuptake inhibitors, causing increased blood levels of these drugs and the potential of subsequent toxicity. * Following administration of<unk> , the elimination half-life and area-under-curve of zolmitriptan and its active metabolites were roughly doubled. *<unk>  is a potent inhibitor of tubular creatinine secretion. Creatinine is a metabolic byproduct of creatine breakdown. Accumulation of creatinine is associated with uremia, but the symptoms of creatinine accumulation are unknown, as they are hard to separate from other nitrogenous waste buildups. * Like several other medications (e.g. erythromycin),<unk>  interferes with the body's metabolization of sildenafil, causing its strength and duration to increase (therefore also its side effects to be more likely and prominent). * Clinically significant drug interactions with the CYP1A2 substrate theophylline, the CYP2C9 substrate tolbutamide, the CYP2D6 substrate desipramine, and the CYP3A4 substrate triazolam have all been demonstrated with<unk> , and interactions with other substrates of these enzymes are likely as well. *<unk>  has been shown clinically to reduce the clearance of mirtazapine, imipramine, timolol, nebivolol, sparteine, loratadine, nortriptyline, gabapentin, and desipramine in humans. *<unk>  inhibits the renal excretion of metformin and procainamide, resulting in increased circulating levels of these drugs. * Interactions of potential clinical importance with<unk>  include warfarin, theophylline, phenytoin, carbamazepine, pethidine and other opioid analgesics, tricyclic antidepressants, lidocaine, terfenadine, amiodarone, flecainide, quinidine, fluorouracil, and benzodiazepines. *<unk>  may decrease the effects of CYP2D6 substrates that are prodrugs, such as codeine, tramadol, and tamoxifen. *<unk>  reduces the absorption of ketoconazole and itraconazole (which require a low pH). *<unk>  has a theoretical but unproven benefit in paracetamol toxicity. This is because N-acetyl-p-benzoquinone imine (NAPQI), a metabolite of paracetamol (acetaminophen) that is responsible for its hepatotoxicity, is formed from it by the cytochrome P450 system (specifically, CYP1A2, CYP2E1, and CYP3A4). * Used in cancer metastasis research as a blocker of E-selectin. * Numerous other drug interactions.
Cimetidine
Azacitidine
Ranitidine
Sucralfate
Dexlansoprazole
Lansoprazole
Rabeprazole
Pantoprazole