Around 1850, three authors, Carl Wedl, Franciscus Donders, and Heinrich Müller, gave<unk>  different labels.<unk> , the hallmark of AMD, were first described in 1854 by Wedl. Wedl named them colloid bodies of the choroid and thought that they were incompletely developed cells. Franciscus Donders called them "Colloidkugeln" (colloid spheres). Later, Heinrich Müller named them by the German word for geode, based on their glittering appearance. He was convinced that<unk>  originated from the nuclei of the pigment cells, which he believed to belong to the choroid. In view of their location between the retinal pigment epithelium (RPE) and its vascular supply, the choriocapillaris, it is possible that<unk>  deprive the RPE and photoreceptor cells of oxygen and nutrients. In some cases,<unk>  develop above the so-called pillars of the choriocapillaris that is the area between two micro vessels; although important variations are observed between different subtypes of AMD.<unk>  in Optical Coherence Tomography. The source of the proteins and lipids in<unk>  is also not clear, with potential contributions by both the RPE and the choroid. Several trace elements are present in<unk> , probably the most concentrated being zinc. The protein composition of<unk>  includes apolipoproteins and oxidized proteins, likely originating from blood, RPE, and photoreceptors.<unk>  composition also includes members of the complement system. Zinc in<unk>  has been suggested to play a role in<unk>  formation by precipitating and inhibiting the elements of the complement cascade, especially complement factor H. The presence of molecules that regulate inflammation in<unk>  has led some investigators to conclude that these deposits are product of the immune system.
Drusen
Crusaid
Aneugen
Keldur
Lipotuck
Splinter
Otenaproxesul
Earwax