Published studies on the survival of<unk> 's<unk>  patients are limited in varied respects, perhaps owing to the relatively small sample sizes, and the fact that secondary<unk> 's<unk>  is associated with other autoimmune diseases. Results from a number of studies indicate that, compared to other autoimmune diseases,<unk> 's<unk>  is associated with a notably high incidence of malignant non-Hodgkin lymphoma, a cancer of white blood cells. About 5% of patients with SS develop some form of lymphoid malignancy. Patients with severe cases are much more likely to develop lymphomas than patients with mild or moderate cases. The most common lymphomas are salivary extranodal marginal zone B cell lymphomas (MALT lymphomas in the salivary glands) and diffuse large B-cell lymphoma. Lymphomagenesis in primary<unk> 's<unk>  patients is considered as a multistep process, with the first step being chronic stimulation of autoimmune B cells, especially B cells that produce rheumatoid factor at sites targeted by the disease. This increases the frequency of oncogenic mutation, leading to any dysfunction at checkpoints of autoimmune B-cell activation to transform into malignancy. A study's finding has concluded the continuous stimulation of autoimmune B cells, leading to subtle germinal abnormalities in genes having specific consequences in B cells, which underlies the susceptibility to lymphoma. Apart from this notably higher incidence of malignant NHL,<unk> 's patients show only modest or clinically insignificant deterioration in specific organ-related function, which explains the only slight increases in mortality rates of<unk> 's patients in comparison with the remainder of the population.<unk> 's<unk>  is associated with a high burden of illness, and has been shown to markedly reduce quality of life (QoL), with a significant impact on ability to work resulting from increased rates of disability. The reduction in QoL is similar to that seen in other chronic conditions such as rheumatoid arthritis, lupus and fibromyalgia.
Sjögren syndrome
Sjögren–Larsson syndrome
CREST syndrome
Auto-brewery syndrome
Neuro-Behçet's disease
Chilaiditi syndrome
Juvenile dermatomyositis
Tumid lupus erythematosus