<unk>  does not require treatment. In<unk> , breast hypertrophy will usually stop completely and patients will experience regression of the breast tissue over 3 to 60 months. Less commonly, patients may remain with residual breast tissue or continue through cycles of breast hypertrophy and regression until puberty. Diagnostics are utilised in individuals with<unk> , especially at the presentation of other secondary sex characteristics. Diagnostics aim to ensure<unk>  patients are not suffering from CPP. Pelvic Ultrasounds Pelvic ultrasounds are important in diagnosing CPP. Patients with CPP have an increased ovary and uterus size. The ovary and uterus volume of CPP patients is similar to that of females undergoing puberty. The pelvis ultrasound is problematic as a diagnostic, as there is not a specific cut-off for the uterine and ovary volumes that indicate the patient has CPP. Patients with<unk>  should have a uterine and ovarian volume within the normal range for their age. Pelvic ultrasounds are a desirable diagnostic as they are non-invasive and easy to continually review. The pelvic ultrasound should be paired with biochemical tests to determine the presence of CPP. Biochemical tests Biochemical tests study the hormone levels in patients. CPP patients have elevated LH levels and peak LH:FSH ratios when compared to<unk>  patients. It is hard to use LH as a diagnostic for CPP, as the LH assay has varying sensitivity and specificity. The GnRH stimulation test is the main diagnostic biochemical test used to distinguish<unk>  from CPP. The GnRH test demonstrates the pituitary responsiveness to GnRH. GnRH stimulates the release of LH and FSH from the anterior pituitary. The peak LH:FSH ratio in CPP patients is similar to the ratio of pubertal females. Females with<unk>  demonstrated a LH:FSH ratio lower than pubertal females. The disadvantages of the GnRH stimulation test is it takes a long time to perform and requires multiple collections from the patient, making the process time consuming and inconvenient. The test is highly specific but has low sensitivity as the LH hormone response is usually observed in later stages of CPP. There are also overlaps in the expected value in the GnRH test results of individuals with CPP and<unk> . Combined diagnostic approach The diagnostic inconsistency in CPP means that a combination of all of pelvic ultrasounds and biochemical tests should be paired with observation, to ensure<unk>  doesn’t progress to CPP.
Premature thelarche
Panner disease
Prepubertal hypertrichosis
Microorchidism
Uncombable hair syndrome
Tricho–dento–osseous syndrome
Sexual maturation disorder
Adiposogenital dystrophy