Disability-adjusted life years lost due to<unk>  per 100,000 inhabitants in 2004.<unk>  has great human and economic costs. It results in a decreased life expectancy of 20 years. This is primarily because of its association with obesity, poor diet, a sedentary lifestyle, and smoking, with an increased rate of suicide playing a lesser role. Side effects of antipsychotics may also increase the risk. These differences in life expectancy increased between the 1970s and 1990s. An Australian study puts the rate of early death at 25 years, and views the main cause to be related to heart disease. Almost 40% of those with<unk>  die from complications of cardiovascular disease which is seen to be increasingly associated. An underlying factor of sudden cardiac death may be Brugada syndrome (BrS) – BrS mutations that overlap with those linked with<unk>  are the calcium channel mutations. BrS may also be drug-induced from certain antipsychotics and antidepressants. Primary polydipsia, or excessive fluid intake, is relatively common in people with chronic<unk> . This may lead to hyponatremia which can be life-threatening. Antipsychotics can lead to a dry mouth, but there are several other factors that may contribute to the disorder; it may reduce life expectancy by 13 per cent. Barriers to improving the mortality rate in<unk>  are poverty, overlooking the symptoms of other illnesses, stress, stigma, and medication side effects.<unk>  is a major cause of disability. In 2016 it was classed as the 12th most disabling condition. Approximately 75% of people with<unk>  have ongoing disability with relapses and 16.7 million people globally are deemed to have moderate or severe disability from the condition. Some people do recover completely and others function well in society. Most people with<unk>  live independently with community support. About 85% are unemployed. In people with a first episode of psychosis in<unk>  a good long-term outcome occurs in 31%, an intermediate outcome in 42% and a poor outcome in 31%. Males are affected more often than females, and have a worse outcome; some reports find there is no difference in prevalence. Outcomes for<unk>  appear better in the developing than the developed world. These conclusions have been questioned. Social problems, such as long-term unemployment, poverty, homelessness, exploitation, stigmatization and victimization are common consequences, and lead to social exclusion. There is a higher than average suicide rate associated with<unk>  estimated at around 5% to 6%, most often occurring in the period following onset or first hospital admission. Several times more (20 to 40%) attempt suicide at least once. There are a variety of risk factors, including male gender, depression, a high IQ, heavy smoking, and substance use. Repeated relapse is linked to an increased risk of suicidal behavior. The use of clozapine can reduce the risk of suicide and aggression. A strong association between<unk>  and tobacco smoking has been shown in worldwide studies. Smoking is especially high in those diagnosed with<unk> , with estimates ranging from 80 to 90% being regular smokers, as compared to 20% of the general population. Those who smoke tend to smoke heavily, and additionally smoke cigarettes with high nicotine content. Some propose that this is in an effort to improve symptoms. Among people with<unk>  use of cannabis is also common.<unk>  leads to an increased risk of dementia. Women with<unk>  are half as likely to attend breast cancer<unk> reening compared to the general population. This is seen as one of the factors leading to shorter life expectancy.
Schizophrenia
Delusional disorder
Disorganized schizophrenia
Schizoaffective disorder
Simple-type schizophrenia
Autism
Schizophreniform disorder
Bipolar disorder