This<unk>  does not only impact humans, but other animals such as monkeys, mice, and dogs have been observed to develop<unk>  as well. While certain gene deletions are more frequent than others, novel mutations resulting in<unk>  have been discovered worldwide. Most commonly, the underlying cause of the<unk>  is a deletion of a GALC gene, which causes a deficiency in the GALC enzyme. This is the circumstance in 80% of patients who have European and Mexican origins. The mortality rate of early infantile<unk>  is 90% before the age of two. Later onset of symptoms is associated with longer life expectancy, with older children generally surviving two to seven years after the initial diagnosis.<unk>  occurs in about one in 100,000 births. Because the<unk>  is genetic, incidence rates vary widely from population to population. The incidence rate is extremely low in Japan, with between 5 and 10 cases per 1,000,000 live births. In the United States,<unk>  occurs in approximately 1 out of every 100,000 live births. Scandinavian countries report incidence rates of one in 50,000 births. In certain communities<unk>  is much more frequent, such as the Druze community in Israel, which has an incidence rate of 6 out of every 1,000 live births. This higher rate is thought to be due in part to a high frequency of consanguineous marriages. Almost 35% of all Druze marriages were found to be between first-cousin familial relations. There have been no reported cases of<unk>  among the Jewish community. Time of onset also varies in frequency by location. Early infantile<unk>  is the most common form of the<unk>  overall, but Nordic communities tend to have even higher rates of early infantile onset<unk> , while Southern European countries have higher incidences of late-onset cases. It is difficult to estimate the incidence of adult-onset<unk> , due to discrepancies in classifying cases late-onset versus adult-onset.
Krabbe disease
Foster Kennedy syndrome
Batten disease
Sandhoff disease
Stratton Parker syndrome
Warburg Micro syndrome
Fukuyama congenital muscular dystrophy
Dejerine–Sottas disease