Pharmacodynamics<unk>  acts as a serotonin reuptake inhibitor (IC50 = 2.1 nM; Ki = 0.1 nM) and 5-HT1A receptor partial agonist (IC50 = 0.2 nM; IA = ~60–70%). It has negligible affinity for other serotonin receptors such as 5-HT1D, 5-HT2A, and 5-HT2C. It also exhibits clinically unimportant inhibitory activity at the norepinephrine and dopamine transporters (Ki = 56 nM for NET and 37 nM for DAT). A small clinical study found occupancy of the 5-HT1A receptor with<unk> , whereas occupancy of the SERT by<unk>  in humans does not seem to have been studied. Pharmacokinetics<unk>  is best absorbed with food and has a bioavailability of 72% under fed conditions. The Cmax increased between 147 to 160% and the AUC increased between 64 to 85% of<unk>  when it was administered with either a fatty or light meal.
Vilazodone
Hydrocodone
Nefazodone
Trazodone
Tapentadol
Naltrexone
Tramadol
Norhydrocodone