<unk>  is produced naturally in the human body, but the long-term effects of its use are largely unknown. In the short term, several studies have noted few adverse effects. In a study by Chang et al.,<unk>  was administered at a dose of 200 mg/day for 24 weeks with slight androgenic effects noted. Another study utilized a dose up to 400 mg/day for 8 weeks with few adverse events reported. A longer-term study followed patients dosed with 50 mg of<unk>  for 12 months with the number and severity of side effects reported to be small. Another study delivered a dose of 50 mg of<unk>  for 10 months with no serious adverse events reported. As a hormone precursor, there have been reports of side effects possibly caused by the hormone metabolites of<unk> . It is not known whether<unk>  is safe for long-term use. Some researchers believe<unk>  supplements might actually raise the risk of breast cancer, prostate cancer, heart disease, diabetes, and stroke.<unk>  may stimulate tumor growth in types of cancer that are sensitive to hormones, such as some types of breast, uterine, and prostate cancer.<unk>  may increase prostate swelling in men with benign prostatic hyperplasia (BPH), an enlarged prostate gland.<unk>  is a steroid hormone. High doses may cause aggressiveness, irritability, trouble sleeping, and the growth of body or facial hair on women. It also may stop menstruation and lower the levels of HDL ("good" cholesterol), which could raise the risk of heart disease. Other reported side effects include acne, heart rhythm problems, liver problems, hair loss (from the scalp), and oily skin. It may also alter the body's regulation of blood sugar.<unk>  may promote tamoxifen resistance in breast cancer. It may also increase the risk of uterine and prostate cancers due to metabolism into estrogens and androgens, respectively. Patients on hormone replacement therapy may have more estrogen-related side effects when taking<unk> . This supplement may also interfere with other medicines, and potential interactions between it and drugs and herbs are possible.<unk>  is possibly unsafe for individuals experiencing pregnancy, breastfeeding, hormone sensitive conditions, liver problems, diabetes, depression or mood disorders, polycystic ovarian syndrome (PCOS), or cholesterol problems.<unk>  has been reported to possess few or no side effects even at very high dosages (e.g., 50 times the recommended over-the-counter supplement dosage). However, it may cause masculinization and other androgenic side effects in women and gynecomastia and other estrogenic side effects in men.
Prasterone
Chlordecone
Enoximone
Dipipanone
Azacyclonol
Methasterone
Iomeprol
Crotamiton