In terms of the normal mechanism of T<unk>  we find that it is a type of white blood<unk>  that has an important role in immunity, and is made from thymocytes. One sees in the partial disorder of T<unk> s that happen due to<unk>  signaling defects, are usually caused by hypomorphic gene defects. Generally, (micro)deletion of 22Q11.2 is the most often seen. Pathogens of concern The main pathogens of concern in<unk> es are intracellular pathogens, including Herpes simplex virus, Mycobacterium and Listeria. Also, intracellular fungal infections are also more common and severe in<unk> es. Other intracellular pathogens of major concern in<unk>  are:
T cell deficiency
IgG deficiency
Thymic hypoplasia
Humoral immune deficiency
Combined immunodeficiencies
Primary immunodeficiency
Leukocyte adhesion molecule deficiency
Leukocyte adhesion deficiency