<unk> , or Mucopolysaccharidosis Type VI (MPS-VI), is an inherited disease caused by a deficiency in the enzyme arylsulfatase B (ARSB). ASRB is responsible for the breakdown of large sugar molecules called glycosaminoglycans (GAGs, also known as mucopolysaccharides). In particular, ARSB breaks down dermatan sulfate and chondroitin sulfate. Because people with MPS-VI lack the ability to break down these GAGs, these chemicals build up in the lysosomes of cells. MPS-VI is therefore a type of lysosomal storage disease.
Maroteaux–Lamy syndrome
Mucopolysaccharidosis
Coffin–Siris syndrome
Griscelli syndrome type 2
Dunnigan familial partial lipodystrophy
Wilson–Mikity syndrome
Marfanoid–progeroid–lipodystrophy syndrome
Gianotti–Crosti syndrome