MS can be classified based on the type of ion to which they are permeable. Cation Selective MSCs: As the name suggests, they exhibit a selective permeability for positive ions with the most selective<unk>  being those for K+. The most common eukaryotic MSCs are cation selective passing Na+, K+ and Ca2+ but not Mg2+. They have a single<unk> conductance range (25-35 pS) and they are blocked by trivalent ion Gadolinium. The K+ selective MSCs such as TREK-1 are not blocked by Gd3+. Anion<unk> : they exhibit a significant permeability for negative ions, and are not predominant as cation MS. They have a large conductance range (> 300pS). Non Selective ion<unk> : As the name indicates, they do not differentiate between positive and negative<unk>  those are more common to Archaea and Bacteria, but rarely found in Eukarya. Broadly, most MS can be classified as lipid-gated<unk>
Mechanosensitive channels
Cyclic nucleotide–gated ion channel
Glutamate transporter
SK channel
Norepinephrine transporter
Voltage-gated ion channel
Neurotransmitter transporter
G protein-gated ion channel