LCC is, in effect, a "diagnosis of exclusion", in that the tumor cells lack light microscopic characteristics that would classify the neoplasm as a small-cell carcinoma, squamous-cell carcinoma, adenocarcinoma, or other more specific histologic type of lung cancer. LCC is differentiated from small-cell lung carcinoma (SCLC) primarily by the<unk> r size of the anaplastic cells, a higher cytoplasmic-to-nuclear size ratio, and a lack of "salt-and-pepper" chromatin. Classification The newest revisions of the World Health Organization (WHO) "Histological Typing of Lung Cancer schema" include several variants of LCC, including: * Giant-cell carcinoma of the lung * Basaloid<unk>  cell carcinoma of the lung * Clear cell carcinoma of the lung * Lymphoepithelioma-like carcinoma of the lung *<unk>  with rhabdoid phenotype *<unk>  cell neuroendocrine carcinoma of the lung<unk> -cell neuroendocrine carcinoma (LCNEC) One clinically significant subtype is<unk> -cell neuroendocrine carcinoma" (LCNEC), which is believed to derive from neuroendocrine cells. In addition, a "subvariant", called "combined<unk> -cell neuroendocrine carcinoma" (or c-LCNEC), is recognized under the new system. To be designated a c-LCNEC, the tumor must contain at least 10% LCNEC cells, in combination with at least 10% of other forms of NSCLC. Pathology images File:Large cell carcinoma of the lung.jpg File:Large cell carcinoma of the lung .jpg
Large-cell lung carcinoma
Giant-cell carcinoma of the lung
Epithelial-myoepithelial carcinoma of the lung
Sarcomatoid carcinoma of the lung
Non-small-cell lung carcinoma
Mesothelioma
Adenosquamous lung carcinoma
Adenocarcinoma of the lung