<unk>  (also known medically by several other names) is a feeling that originates in<unk> , and is caused by damaging stimuli. It occurs as a result of a wide range of diseases or physical conditions or both, and may severely impair the quality of life.<unk>  belongs to the class of deep somatic<unk> , often experienced as a dull<unk>  that cannot be localized accurately by the patient. This is in contrast with the<unk>  which is mediated by superficial receptors in, e.g., the skin.<unk>  can have several possible causes ranging from extensive physical stress to serious diseases such as cancer. For many years it has been known that<unk> s are innervated with sensory neurons. Yet their exact anatomy remained obscure due to the contrasting physical properties of<unk>  and neural tissue. More recently, it is becoming clear what types of nerves innervated which sections of<unk> . The periosteal layer of<unk>  tissue is highly<unk> -sensitive and an important cause of<unk>  in several disease conditions causing<unk> , like fractures, osteoarthritis, etc. However, in certain diseases the endosteal and haversian nerve supply seems to play an important role, e.g. in osteomalacia, osteonecrosis, and other<unk>  diseases. Thus, there are several types of<unk> , each with many potential sources or origins of cause.
Bone pain
Weather pains
Breast hypertrophy
Myalgia
Breast atrophy
Joint stiffness
Osteopathy
Dark skin