* Head * Macrocephaly * The disease is characterized by megalencephaly, the enlargement of the brain, which is followed by an increase in the size of the actual head. * Central Nervous System * Megalencephaly * The M in<unk>  stands for “megalencephaly”, the enlargement of the brain * Ataxia * Slow, progressive and early-onset cerebellar ataxia has been noted in many patients * Spasticity * Patients with<unk>  often have muscle spasms * Seizures * Delay in motor development * Mild mental retardation * Diffuse swelling of cerebral white matter * Large<unk><unk>  in frontal and temporal lobes * Patients develop<unk>  on the tips of the temporal and<unk>  area * Diffuse spongiform leukoencephalopathy * Vacuolizing myelinopathy * The protective myelin sheath on neurons pulls away from their cells forming small holes in nerve fibers – in turn affecting coordination and walking ability.
Megalencephalic leukoencephalopathy with subcortical cysts
Leukoencephalopathy with neuroaxonal spheroids
Leukoencephalopathy with vanishing white matter
Camel spongiform encephalopathy
Diffuse intrinsic pontine glioma
Powassan encephalitis
Neurodegeneration with brain iron accumulation
Wernicke encephalopathy