<unk>  is typically given with a sulfonamide and folinic acid. It is used for the treatment of toxoplasmosis, actinomycosis, and isosporiasis, and for the treatment and prevention of Pneumocystis jirovecii pneumonia. Toxoplasmosis<unk>  is also used in combination with sulfadiazine to treat active toxoplasmosis. The two drugs bind the same enzymatic targets as the drugs trimethoprim and sulfamethoxazole - dihydrofolate reductase and dihydropteroate synthase, respectively.<unk>  has also been used in several trials to treat retinochoroiditis. Pregnancy consideration<unk>  is labeled as pregnancy category C in the United States. To date, not enough evidence on its risks in pregnancy or its effects on the fetus is available. Malaria It is primarily active against Plasmodium falciparum, but also against Plasmodium vivax. Due to the emergence of<unk> -resistant strains of P. falciparum,<unk>  alone is seldom used now. In combination with a long-acting sulfonamide such as sulfadiazine, it was widely used, such as in Fansidar, though resistance to this combination is increasing.
Pyrimethamine
Quinine
Artemether
Phenpromethamine
Primaquine
Chloroquine
Mefloquine
Dimetacrine