<unk>  forming along thumb The skin lesions evolve through characteristic stages: # blistering (from birth to about four months of age), # a wart-like rash (for several months), # swirling macular hyperpigmentation (from about six months of age into adulthood), followed by # linear hypopigmentation. Alopecia, dental anomalies, and dystrophic nails are observed. Some patients have retinal vascular abnormalities predisposing to retinal detachment in early childhood. Cognitive delays or intellectual disability are occasionally seen. The discolored skin is caused by excessive deposits of melanin (normal skin<unk> . Most newborns with<unk>  will develop discolored skin within the first two weeks. The<unk> tion involves the trunk and extremities, is slate-grey, blue or brown, and is distributed in irregular marbled or wavy lines. The discoloration sometimes fades with age. Neurological problems can include cerebral atrophy, the formation of small cavities in the central white matter of the brain, and the loss of neurons in the cerebellar cortex. About 20% of children with<unk>  will have slow motor development, muscle weakness in one or both sides of the body, intellectual disability, and seizures. They are also likely to have visual problems, which can include: crossed eyes, cataracts, retinal detachment, and severe visual loss. Dental problems are also common, and can include hypodontia, abnormally shaped teeth, and delayed tooth eruption. Breast anomalies can occur in 1% of patients and can include hypoplasia or supernumerary nipples. Skeletal and structural anomalies can occur in approximately 14% of patients, including: * Somatic asymmetry * Hemivertebrae * Scoliosis * Spina bifida * Syndactyly * Acheiria (congenital absence of the hands - note: other limbs may be affected) * Ear anomalies * Extra ribs * Skull deformities
Incontinentia pigmenti
Dementia praecox
Camel spongiform encephalopathy
Autistica
Multiple evanescent white dot syndrome
Keshan disease
Familial Danish dementia
Semantic dementia