SS can be classified based upon the clinical setting in which it occurs: classical or idiopathic SS, malignancy-associated SS, and drug-induced SS. Systemic diseases SS is a reactive phenomenon and should be considered a cutaneous marker of systemic disease. Careful systemic evaluation is indicated, especially when cutaneous lesions are severe or hematologic values are abnormal. Approximately 20% of cases are associated with malignancy, predominantly hematological, especially acute myelogenous leukemia (AML). An underlying condition (streptococcal infection, inflammatory bowel disease, nonlymphocytic leukemia and other hematologic malignancies, solid tumors, pregnancy) is found in up to 50% of cases. Attacks of SS may precede the hematologic diagnosis by 3 months to 6 years, so that close evaluation of patients in the “idiopathic” group is required. There is now good evidence that treatment with hematopoietic growth factors—including granulocyte colony-stimulating factor (G-CSF), which is used to treat AML, and granulocyte-macrophage colony-stimulating factor—can cause SS. Lesions typically occur when the patient has leukocytosis and<unk>  but not when the patient is neutropenic. However, G-CSF may cause SS in neutropenic patients because of the induction of stem cell proliferation, the differentiation of neutrophils, and the prolongation of neutrophil survival. Associations Although it may occur in the absence of other known disease, SS is often associated with hematologic disease (including leukemia), and immunologic disease (rheumatoid arthritis, inflammatory bowel disease, Behçet's syndrome). Pregnancy associated Sweet syndrome typically present in first or second trimester. It may recur with subsequent pregnancy, but there seems to be no risk to the fetus. A genetic association has been suggested, but no specific genetic link has been identified.
Febrile neutrophilic dermatosis
Behçet's disease
Streptococcal intertrigo
Drug eruption
Poikiloderma vasculare atrophicans
Toxic epidermal necrolysis
Restrictive dermopathy
Cutaneous lupus mucinosis