Although generally well tolerated, the most common adverse reactions associated with<unk>  are changes in white blood cell counts, local reactions at site of administration, rash, and diarrhea. Incidence of adverse effects greater than 1%: * Eosinophilia (6%) * Thrombocytosis (5.1%) * Elevations in liver enzymes (3.1–3.3%) * Diarrhea (2.7%) * Leukopenia (2.1%) * Elevation in BUN (1.2%) * Local reactions: pain, tenderness, irritation (1%) * Rash (1.7%) Some less frequently reported adverse events (incidence < 1%) include phlebitis, itchiness, fever, chills, nausea, vomiting, elevations of bilirubin, elevations in creatinine, headache and dizziness.<unk>  may precipitate in bile, causing biliary sludge, biliary pseudolithiasis, and gallstones, especially in children. Hypoprothrombinaemia and bleeding are specific side effects. Haemolysis is reported. It has also been reported to cause post kidney failure in children. Like other antibiotics,<unk>  use can result in Clostridium difficile-associated diarrhea ranging from mild diarrhea to fatal colitis. Contraindications<unk>  should not be used in those with an allergy to<unk>  or any component of the formulation. Although there is negligible<unk> ss-reactivity between penicillins and third-generation cephalosporins, caution should still be used when using<unk>  in penicillin-sensitive patients. Caution should be used in people who have had previous severe penicillin allergies. It should not be used in hyperbilirubinemic neonates, particularly those who are premature because<unk>  is reported to displace bilirubin from albumin binding sites, potentially causing bilirubin encephalopathy. Concomitant use with intravenous calcium-containing solutions/products in neonates (≤28 days) is contraindicated even if administered through different infusion lines due to rare fatal cases of calcium-ceftriaxone precipitations in neonatal lungs and kidneys.
Ceftriaxone
Meropenem
Levofloxacin
Cefotaxime
Azithromycin
Cefepime
Vancomycin
Ampicillin