<unk>  results from mutations in the<unk>  gene, which codes for the protein gigaxonin. This alters the shape of the protein, changing how it interacts with other proteins when organizing the structure of the neuron. Neurons affected by the altered protein accumulate excess neurofilaments in the axon, the long extension from the nerve cell that transmits its signal to other nerve cells and to muscles. These enlarged or<unk> ' axons cannot transmit signals properly, and eventually deteriorate, resulting in the range of neurological anomalies associated with the disorder. This disease is an autosomal recessive disorder, which means the defective gene is located on an autosome, and both parents must have one copy of the defective gene in order to have a child born with the disorder. The parents of a child with an autosomal recessive disorder are carriers, but are usually not affected by the disorder.
Giant axonal neuropathy
Polyneuropathy
Tropical neuropathy
Small fiber peripheral neuropathy
Chronic inflammatory demyelinating polyneuropathy
Peripheral mononeuropathy
Diabetic neuropathy
Vasculitic neuropathy