Mechanism of action<unk>  inhibits the fungal enzyme 14α-sterol demethylase, resulting in a reduced production of ergosterol. In addition to its antifungal actions,<unk> , similarly to ketoconazole, is known to act as an antagonist of the glucocorticoid receptor. Pharmacokinetics After application to the skin,<unk>  can be measured in the skin for up to four days, but less than 1% is absorbed into the bloodstream. When applied to the oral mucosa (and possibly also for vaginal use), it is significantly absorbed. In the bloodstream, 88.2% are bound to plasma proteins and 10.6% to blood cells. The substance is partly metabolized via the liver enzyme CYP3A4 and mainly eliminated via the faeces.
Miconazole
Itraconazole
Terbinafine
Ketoconazole
Sertaconazole
Posaconazole
Efinaconazole
Nystatin