As defined by microscopic histopathology analyses, GCF tumors consist of a few spindle- and/or stellate-shaped<unk> s in a sclerotic (i.e. collagen fiber-rich) background with distinctive dilated blood vessel-like spaces lined by floret-shaped (i.e. small flower-shaped) multinuclear<unk> <unk> s. The<unk> <unk> s vary in size and shape with their nuclei often lined-up in wreath-like or lobular formations. The tumors may infiltrate into and through nearby subcutaneous fat tissue, commonly have intralesional hemorrhages and distinctive perivascular onionskin-like lymphocytes, and occasionally contain nodules of smooth muscle-like<unk> s. Some GCF tumors have hybrid characteristics with areas resembling DFSP (e.g. immature-appearing spindle- and/or stellate-shaped<unk> s with abnormally dark nuclei arranged in a monotonous cartwheel or whorled pattern). These hybrid lesions typical have pure GCF-like areas, pure DFSP-like areas, and mixed areas with a gradual or abrupt transition from one to the other. Surgically removed GCF may recur as a DFSP (and vice versa). (DFSP-FS tumors consist of rapidly growing bundles of spindle- and/or stellate-shaped<unk> s with vesicle-containing, abnormally shaped nuclei.) Immunohistochemistry analyses indicate that the tumor<unk> s in GCF express CD34 and vimentin proteins but not epithelial membrane antigen (also termed MUC1), ACTA2 (also termed α-SMA), desmin, HMB-45, keratin, S100, or MLANA (also termed Melan-A) proteins.
Giant-cell fibroblastoma
Spindle cell lipoma
Littoral cell angioma
Angiomyofibroblastoma
Sclerosing epithelioid fibrosarcoma
Cellular angiofibroma
Ameloblastic fibroma
Mammary-type myofibroblastoma