Most patients present with an immunodeficient state and recurrent sinopulmonary infections in their 4th or 5th decade of life. The<unk>  may occur before or after the diagnosis of a<unk> .<unk>  involves both deficient humoral and cellular immunity. Patients have low total serum antibodies. The<unk>  may inhibit the thymus’s normal role in production of self-tolerant T lymphocytes. These T-lymphocytes then attack the B cell precursors in the marrow, preventing maturation and ultimately resulting in hypogammaglobulinemia. Good Syndrome is associated with other autoimmune conditions including pure red cell aplasia and myasthenia gravis.
Thymoma with immunodeficiency
Primary mediastinal B-cell lymphoma
Thymic carcinoma
AIDS-related lymphoma
Diffuse infiltrative lymphocytosis syndrome
Primary effusion lymphoma
Aggressive lymphoma
Hodgkin lymphoma