The first synthesis of<unk>  was disclosed in a patent filed by Emory University in 2018. In the first step, acetone is used as a protecting group to render two of the three hydroxy groups of uridine unreactive to treatment with the acid anhydride of isobutyric acid, which converts the third hydroxy group to its ester. Treatment with 1,2,4-triazole and phosphoryl chloride produces a reactive intermediate in which the triazole portion can be replaced with hydroxylamine. Finally, removal of the protecting group using formic acid converts the material to<unk> . :650px Alternative patented routes to<unk>  have been reviewed.
Molnupiravir
Balapiravir
Odalasvir
Saquinavir
Remdesivir
Coronavir
Favipiravir
Maribavir