Hypothesized treatment options include the use of antioxidants, cognitive behavioral therapy, erythropoietin and stimulant drugs such as methylphenidate, though as the mechanism of PCCI is not well understood the potential treatment options are equally theoretical. Modafinil, approved for narcolepsy, has been used off-label in trials with people with symptoms of PCCI. Modafinil is a wakefulness-promoting agent that can improve alertness and concentration, and studies have shown it to be effective at least among women treated for breast cancer. While estrogen hormone supplementation may reverse the symptoms of PCCI in women treated for breast cancer, this carries health risks, including possibly promoting the proliferation of estrogen-responsive breast cancer cells.
Post-chemotherapy cognitive impairment
Paraneoplastic syndrome
Postmenopausal confusion
Postoperative cognitive dysfunction
AIDS fatigue
Sleeping disorders following traumatic brain injury
Autoimmune disease in women
Chemotherapy-induced peripheral neuropathy