<unk>  is an inherited metabolic disorder in which the body is unable to use the vitamin biotin effectively. This disorder is classified as a multiple carboxylase deficiency, a group of disorders characterized by impaired activity of certain enzymes that depend on biotin. Symptoms are very similar to biotinidase deficiency and treatment – large doses of biotin – is also the same.
Holocarboxylase synthetase deficiency
Malonyl-CoA decarboxylase deficiency
Guanidinoacetate methyltransferase deficiency
Carbamoyl phosphate synthetase I deficiency
2,4 Dienoyl-CoA reductase deficiency
Pyruvate kinase deficiency
Ornithine translocase deficiency
Aminoacylase 1 deficiency