<unk>  (THRLBCL) is a malignancy of B-cells. B-cells are lymphocytes that normally function in the humoral immunity component of the adaptive immune system by secreting antibodies that, for example, bind to and neutralize invasive pathogens. Among the various forms of B-cell<unk> s, THRLBCL is a rarely occurring subtype of the diffuse large B-cell<unk> s (DLBCL). DLBCL are a large group of<unk> s that account for ~25% of all non-Hodgkin<unk> s worldwide. THRLBCL is distinguished from the other DLBCL subtypes by the predominance of non-malignant T-cell lymphocytes and<unk> s over malignant B-cells in its tumors and tissue infiltrates. THRLBCL commonly afflicts middle-aged individuals but has been diagnosed in rare pediatric cases. The disease usually presents with lymphadenopathy, i.e. bulky enlargements of lymph nodes in the neck, arm pit, or groin. However, most cases are at an advanced stage at diagnoses: further examinations frequently reveal that the disease has spread to multiple internal organs and tissues. The course of the disease is usually characterized as being poorly responsive to treatment: the disease's survival rates in past studies have been only ~46%. However, recent studies suggest that novel treatments can improve these survival rates. Many studies have found that THRLBCL can overlap with the variant form of nodular lymphocyte predominant Hodgkin<unk>  (NLPHL). That is, some cases of variant NLPHL, which is a relatively indolent malignancy, share with THRLBCL similar disease presentations, histologies (i.e. microscopic appearances), genetic abnormalities, and apparent etiologies. Indeed, NLPHL can, in rare cases, progress into THRLBCL. Comapared to THRLBCL, however, these variant NLPHL cases are less aggressive, are more responsive to treatment, and have a better prognosis. Thus, THRLBCL and NLPHL may be biologically related diseases that represent opposite ends of a severity spectrum.
T cell/histiocyte-rich large B-cell lymphoma
Diffuse large B-cell lymphoma associated with chronic inflammation
Germinal center B-cell like diffuse large B-cell lymphoma
Extranodal NK/T-cell lymphoma, nasal type
Fibrin-associated diffuse large B-cell lymphoma
Pediatric-type follicular lymphoma
Nodal marginal zone B cell lymphoma
Marginal zone B-cell lymphoma