The main side effects of<unk>  are androgenic and antiestrogenic in nature. In one study of 2.5 mg oral<unk>  twice per week in women, it caused seborrhea in 71%, acne in 65%, breast hypoplasia in 29%, hirsutism in 9%, and scalp hair loss in 9%. In another study, the rate of androgenic side effects was similarly 50%. Other androgenic side effects that have been reported include oily skin and hair, weight gain, voice deepening, and clitoral enlargement, the latter two of which as well as hirsutism may be irreversible.<unk>  also inhibits gonadotropin secretion and causes amenorrhea or oligomenorrhea in a high percentage of women. Similarly, circulating estradiol levels have been found to be reduced by 50%, which may result in estrogen deficiency and associated symptoms. Studies of 2.5 mg oral<unk>  twice per week have found a rate of amenorrhea of 50 to 58%, while a study of 5 mg oral<unk>  per day found a rate of amenorrhea of 100%. It has been found that vaginal<unk>  shows fewer androgenic side effects and weight gain than oral<unk>  with equivalent effectiveness in endometriosis.<unk>  appears to show similar effectiveness to danazol in the treatment of endometriosis but with fewer side effects, in particular androgenic side effects.
Gestrinone
Gestodene
Mestanolone
Goserelin
Anastrozole
Oxandrolone
Allenestrol
Hexestrol