<unk>  <unk> , being a primary<unk> , is caused by neoplastic proliferation and maturation of erythroid, megakaryocytic and granulocytic elements to produce what is referred to as panmyelosis. In contrast to secondary<unk> s,<unk>  is associated with a low serum level of the hormone erythropoietin (EPO). Instead,<unk>  cells often carry activating mutation in the tyrosine kinase (JAK2) gene, which acts in signaling pathways of the EPO-receptor, making those cells proliferate independent from EPO.
Polycythemia vera
Capillary leak syndrome
Essential thrombocythemia
Aplastic anemia
Primary myelofibrosis
Myomatous erythrocytosis syndrome
Immune thrombocytopenic purpura
Chronic myelogenous leukemia