<unk>  is an extremely rare condition involving thickening of the skin in the palms of the hands and the soles of the feet (hyperkeratosis). This familial disease is associated with a high lifetime risk of esophageal cancer. For this reason, it is sometimes known as tylosis with oesophageal cancer (TOC). The condition is inherited in an autosomal dominant manner, and it has been linked to a mutation in the RHBDF2 gene. It was first described in 1958.
Howel–Evans syndrome
Michels Caskey syndrome
Jackson–Weiss syndrome
Löffler's syndrome
Gómez–López-Hernández syndrome
Fitz-Hugh–Curtis syndrome
Rowell's syndrome
Wissler's syndrome