Although over 100 genes mutations have been identified in<unk>  patients, only NOTCH1 and CDKN2A mutations are considered to be common. In over 50% of pediatric<unk>  cases, mutations in epigenetic regulators have been identified. This activates mutations of NOTCH1 and gene FBXW7 causes the tumor-suppressing gene to lose its functions, leading to<unk> . Near-telomeric location may sometimes generate subtle exchanges in DNA material at the loci involved in oncogenic rearrangements of<unk> . This causes cryptic translocation and therefore deletes the putative tumor suppressor gene CDKN2A (INK4A). At the same time, TLX1 and NOTCH1 may also be activated at higher frequency than usual. The multistep prognosis of<unk>  has hence been said to intensify and rapidly progress due to accumulation of effects resulting from dysregulation of multiple signaling pathways.
T-Cell Acute Lymphoblastic Leukemia
T-lymphoblastic leukemia/lymphoma
Adult T-cell leukemia/lymphoma
Atypical chronic myeloid leukemia
T-cell acute lymphoblastic leukemia
Aggressive NK-cell leukemia
T-cell prolymphocytic leukemia
B-cell prolymphocytic leukemia