The exact mechanism of<unk>  is unknown. It causes a decrease in the speed of action potentials in the central nervous system (CNS). Heat may increase the time when voltage-gated sodium channels are inactivated, which delays further action potentials. This is worsened by the demyelination caused by MS. Other theories have considered the role of heat shock proteins and changes to blood flow. Peripheral nerve studies have shown that even a 0.5 °C increase in body temperature can slow or block the conduction of nerve impulses in demyelinated nerves. With greater levels of demyelination, a smaller increase in temperature is needed to slow down the nerve impulse conduction. Exercising and normal daily activities can cause a significant increase in body temperature in individuals with MS, especially if their mechanical efficiency is poor due to the use of mobility aids, ataxia, weakness, and spasticity. However, exercise has been shown to be helpful in managing MS symptoms, reducing the risk of comorbidities, and promoting overall wellness.
Uhthoff's phenomenon
Lucio's phenomenon
Bell's phenomenon
Renbök phenomenon
Kohnstamm's phenomenon
Jod-Basedow phenomenon
Tullio phenomenon
Waddell's signs