Diagnosis of<unk>  is made by having 2 major criteria or 1 major and 2 minor criteria. The major criteria consist of the following: # more than 2<unk>  or 1 BCC in a person younger than 20 years; # odontogenic keratocysts of the jaw # 3 or more palmar or plantar pits # ectopic calcification or early (<20 years) calcification of the falx cerebri # bifid, fused, or splayed ribs # first-degree relative with<unk> . The minor criteria include the following: # macrocephaly. # congenital malformations, such as cleft lip or palate, frontal bossing, eye anomaly (cataract, coloboma, microphthalmia, nystagmus). # other skeletal abnormalities, such as Sprengel deformity, pectus deformity, polydactyly, syndactyly or hypertelorism. # radiologic abnormalities, such as bridging of the sella turcica, vertebral anomalies, modeling defects or flame-shaped lucencies of hands and feet. # ovarian and cardio fibroma or medulloblastoma (the latter is generally found in children below the age of two). People with<unk>  need education about the syndrome, and may need counseling and support, as coping with the multiple<unk>  and multiple surgeries is often difficult. They should reduce UV light exposure, to minimize the risk of<unk> . They should also be advised that receiving Radiation therapy for their skin cancers may be contraindicated. They should look for symptoms referable to other potentially involved systems: the CNS, the genitourinary system, the cardiovascular system, and dentition. Genetic counseling is advised for prospective parents, since one parent with<unk>  causes a 50% chance that their child will also be affected.
Nevoid basal-cell carcinoma syndrome
Neurofibromatosis
Familial multiple lipomatosis
Hereditary multiple exostoses
Genodermatosis
Frontonasal dysplasia
Neurofibromatosis type I
Multiple hamartoma syndrome