<unk>  is a direct stimulator of soluble guanylate cyclase enzyme, an important enzyme in vascular smooth muscle cells. Specifically,<unk>  will bind to the beta-subunit of the target site on the soluble guanylate cyclase enzyme. Soluble guanylate cyclase enzymes catalyzes the formation of cyclic GMP upon interaction with nitric oxide to activate a number of downstream signaling cascade which can compensate for defects in this pathway and resulting losses in regulatory myocardial and vascular cellular processes due to cardiovascular complications.
Vericiguat
Riociguat
Bosentan
Ambrisentan
Sitaxentan
Colestilan
Darusentan
Macitentan