The bullae are formed by an immune reaction, initiated by the formation of IgG autoantibodies targeting dystonin, also called<unk>  antigen 1, and/or type XVII collagen, also called<unk>  antigen 2, which is a component of hemidesmosomes. A different form of dystonin is associated with neuropathy. Following antibody targeting, a cascade of immunomodulators results in a variable surge of immune cells, including neutrophils, lymphocytes and eosinophils coming to the affected area. Unclear events subsequently result in a separation along the dermoepidermal junction and eventually stretch bullae.
Bullous pemphigoid
Epidermolysis bullosa
Mucous membrane pemphigoid
Vesicular pemphigoid
IgA pemphigus
Paraneoplastic pemphigus
Pemphigoid nodularis
Giant cell lichenoid dermatitis