<unk>  mediates the endocytosis of cholesterol-rich<unk>  and thus maintains the plasma level of<unk> . This occurs in all nucleated cells, but mainly in the liver which removes ~70% of<unk>  from the circulation.<unk> s are clustered in clathrin-coated pits, and coated pits pinch off from the surface to form coated endocytic vesicles that carry<unk>  into the cell. After internalization, the receptors dissociate from their ligands when they are exposed to lower pH in endosomes. After dissociation, the receptor folds back on itself to obtain a closed conformation and recycles to the cell surface. The rapid recycling of<unk> s provides an efficient mechanism for delivery of cholesterol to cells. It was also reported that by association with lipoprotein in the blood, viruses such as hepatitis C virus, Flaviviridae viruses and bovine viral diarrheal virus could enter cells indirectly via<unk> R-mediated endocytosis.<unk> R has been identified as the primary mode of entry for the Vesicular stomatitis virus in mice and humans. In addition,<unk> R modulation is associated with early atherosclerosis-related lymphatic dysfunction. Synthesis of receptors in the cell is regulated by the level of free intracellular cholesterol; if it is in excess for the needs of the cell then the transcription of the receptor gene will be inhibited.<unk> s are translated by ribosomes on the endoplasmic reticulum and are modified by the Golgi apparatus before travelling in vesicles to the cell surface.
LDL receptor
Low-density lipoprotein receptor gene family
Heart-type fatty acid binding protein
Apolipoprotein
Lipoprotein lipase
Tumor-associated glycoprotein 72
Platelet membrane glycoprotein
Cystic fibrosis transmembrane conductance regulator