<unk>  is characterized by early onset of an abnormal gait, speech articulation difficulties, anxiety, and<unk> . The clinical spectrum of symptoms resulting from BHC is vast, manifesting as thyroid agenesis to dysarthria to distress syndrome. As a result, genetic testing is the only way to confirm the syndrome. BHC is caused by a single-nucleotide substitution mutation in TITF1, which encodes thyroid transcription factor 1 (TTF-1) and is inherited in an autosomal dominant pattern. This gene is also known as NK2 homeobox 1 (NKX2-1) The single-nucleotide substitution mutation then ultimately has drastic effects on the maturation processes of TITF-1 In some cases, additional developmental abnormalities of lung and thyroid tissue are found in BHC, leading to the suggested alternative name brain-lung-thyroid syndrome.
Benign hereditary chorea
Non-progressive congenital ataxia
Sydenham's chorea
X-linked dystonia parkinsonism
Autosomal recessive cerebellar ataxia
Autosomal recessive cerebellar ataxia type 1
Spinocerebellar ataxia
Huntington's disease-like syndrome