This disease is known for an indolent clinical course and incidental discovery. The most common physical finding is moderate splenomegaly. B symptoms are seen in a third of cases, and recurrent infections due to anaemia and/or neutropenia are seen in almost half of cases. Rheumatoid arthritis is commonly observed in people with T-LGLL, leading to a clinical presentation similar to Felty's syndrome. Signs and symptoms of anemia are commonly found, due to the association between T-LGLL and erythroid hypoplasia. Sites of involvement The leukemic cells of T-LGLL can be found in peripheral blood, bone marrow, spleen, and liver. Nodal involvement is rare.
Large granular lymphocytic leukemia
Hemophagocytic lymphohistiocytosis
Aggressive NK-cell leukemia
Mixed-phenotype acute leukemia
T-lymphoblastic leukemia/lymphoma
Atypical chronic myeloid leukemia
Diffuse infiltrative lymphocytosis syndrome
Adult T-cell leukemia/lymphoma