<unk>  is used to transmit signals between neighboring cells and acts as a hormone, cytokines, and other signaling molecules. The<unk>  signaling system can trigger inflammatory and thrombotic cascades, amplify these cascades when acting with other mediators, and mediate molecular and cellular interactions (cross talk) between inflammation and thrombosis. Unregulated<unk>  signaling can cause pathological inflammation and has been found to be a cause in sepsis, shock, and traumatic injury.<unk>  can be used as a local signaling molecule and travel over very short distances or it can be circulated throughout the body and act via endocrine.<unk>  initiates an inflammatory response in allergic reactions. This has been demonstrated in the skin of humans and in the paws and skin of lab rabbits and rodents. The inflammatory response is enhanced by the use of vasodilators, including prostaglandin E1 (PGE,) and PGE2 and inhibited by vasoconstrictors.<unk>  also induces apoptosis in a different way that is independent of the<unk>  receptor. The pathway to apoptosis can be inhibited by negative feedback from<unk>  acetylhydrolase <unk> -AH), an enzyme that catabolizes<unk> . It is an important mediator of bronchoconstriction. It causes<unk> s to aggregate and blood vessels to dilate. Thus, it is important to the process of hemostasis. At a concentration of 10−12 mol/L,<unk>  causes life-threatening inflammation of the airways to induce asthma like symptoms. Toxins such as fragments of destroyed bacteria induce the synthesis of<unk> , which causes a drop in blood pressure and reduced volume of blood pumped by the heart, which leads to shock and possibly death.
Platelet-activating factor
Thrombin
Von Willebrand factor
Prothrombinase
Factor VIII 
Factor VIII
Kallikrein
Fibrinogen