<unk>  yields profound antitumoral activity by acting on several immunological levels synergistically.<unk>  stimulates the innate immune system by activating toll-like receptor 7 (TLR7), commonly involved in pathogen recognition. Cells activated by<unk>  via TLR-7 secrete cytokines (primarily interferon-α (IFN-α), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)). There is evidence that<unk> , when applied to skin, can lead to the activation of Langerhans cells, which subsequently migrate to local lymph nodes to activate the adaptive immune system. Other cell types activated by<unk>  include natural killer cells, macrophages and B-lymphocytes.<unk>  exerts its effect by increasing levels of the opioid growth factor receptor (OGFr). In experiments, blocking OGFr function with siRNA technology resulted in loss of any antiproliferative effect of<unk> .
Imiquimod
Clobetasol propionate
Clobetasol
Tretinoin
Cryotherapy
Isotretinoin
Alitretinoin
Elastix 