PPAR Although used clinically since the 1930s, if not earlier, the mechanism of action of<unk> s remained unelucidated until, in the 1990s, it was discovered that<unk> s activate PPAR (peroxisome proliferator-activated receptors), especially PPARα. The PPARs are a class of intracellular receptors that modulate carbohydrate and fat metabolism and adipose tissue differentiation. Activating PPARs induces the transcription of a number of genes that facilitate lipid metabolism.<unk> s are structurally and pharmacologically related to the thiazolidinediones, a novel class of anti-diabetic drugs that also act on PPARs (more specifically PPARγ)<unk> s are a substrate of (metabolized by) CYP3A4.<unk> s have been shown to extend lifespan in the roundworm C. elegans.
Fibrate
Clofibrate
Fish oil
Fish oil 
Macrogol
Fruit salt
Empty calories
Iodised salt