Genetics<unk>  is caused by mutations in the SALL4 gene which is a part of a group of genes called the SALL family. This gene plays an important role in embryonic development by providing instructions to make proteins that are involved in the formation of tissues and organs. SALL proteins act as transcription factors in that they attach themselves to certain regions in DNA in order to help control certain gene activities. Due to the mutations in the SALL4 gene, proteins can not be made because one copy of the gene in each cell is stopped from performing its duty. These mutations are heterozygous and can be nonsense, short duplications, or deletions. At this time, there is no clear reason as to why a reduced amount of the SALL4 protein causes the symptoms of<unk>  and similar conditions.<unk>  is inherited through autosomal dominance meaning that a mutation in one copy of the SALL 4 gene is all it takes to cause this syndrome. Those with this condition can have affected parents, but it can also manifest for the first time with no family history which is called de novo. Since<unk>  is an autosomal dominant disorder, there is a 50% chance of passing the mutation on to offspring.
Duane-radial ray syndrome
Legius syndrome
Heel pad syndrome
Cuboid syndrome
Dead arm syndrome
Anterior interosseous syndrome
Immersion foot syndromes
Femur fibula ulna syndrome