Nearly all people with the condition have<unk> -Hu<unk> bodies in their serum. The<unk> body is produced by the body as an immune system response to<unk>  proteins, which are naturally clustered within the nuclei of neurons in the central and peripheral nervous system. The condition can involve a number of neural structures including the brainstem, cerebellum, spinal cord, dorsal roots, peripheral nerves, and the limbic system of the brain. There is a debate about whether the<unk> body is a cause of, rather than an effect of, the disease process. Older studies suggested the<unk> bodies caused the disease, pointing to the discovery of<unk> body deposition in the brain tissue of patients at autopsy. However, the injection of the<unk> bodies into mice did not produce any disease, and the deposition of<unk> body was often not at the places where brain damage was greatest. Newer studies suggest the<unk> bodies are an effect, not a cause, of the condition, with a consensus that a patient's own T cells are playing a major role in the disease process. These T cells may be activated by the<unk>  proteins. In people with cancer, the cancer has a likely role in the cause of the encephalitis. In a paraneoplastic syndrome, a cancer cell can create proteins that are normally only found as naturally-occurring proteins in other cell types in other parts of the body. In patients with small cell carcinoma of the lung, cancer cells in the lung can produce<unk>  proteins that are usually only found inside of the body's own neurons. It is hypothesized that through these cancer-produced<unk>  proteins, the body creates an immune system response. This reaction includes T cells, which then attack nervous tissue. The cancer-produced<unk>  proteins are found in nearly all small-cell lung carcinomas, 70 percent of neuroblastomas, and a small percentage of other tumors.
Anti-Hu associated encephalitis
Anti-NMDA receptor encephalitis
Anti-VGKC-complex encephalitis
Powassan encephalitis
Post viral cerebellar ataxia
Anti-neurofascin demyelinating diseases
Viliuisk encephalomyelitis
Limbic-predominant age-related TDP-43 encephalopathy