The pathophysiology of<unk>  involves an intense<unk>  overload followed by a failure of the body's thermoregulatory mechanisms. More specifically,<unk>  leads to inflammatory and coagulation responses that can damage the vascular endothelium and result in numerous platelet complications, including decreased platelet counts, platelet clumping, and suppressed platelet release from bone marrow. Growing evidence also suggests the existence of a second pathway underlying<unk>  that involves<unk>  and exercise-driven endotoxemia. Although its exact mechanism is not yet fully understood, this model theorizes that extreme exercise and<unk>  disrupt the intestinal barrier by making it more permeable and allowing lipopolysaccharides (LPS) from gram-negative bacteria within the gut to move into the circulatory system. High blood LPS levels can then trigger a systemic inflammatory response and eventually lead to sepsis and related consequences like blood coagulation, multi-organ failure, necrosis, and central nervous system dysfunction.
Heat stroke
Neuroleptic malignant syndrome
Shark attack
Serotonin syndrome  Serotonin syndrome  1
Dry Drowning
Lightning strike
Spinal shock
Drowning