<unk> , brand name Idefirix, is a medication for the desensitization of highly sensitized adults needing kidney transplantation, but unlikely to receive a compatible transplant.<unk>  is a cysteine protease derived from the immunoglobulin G (IgG)‑degrading enzyme of Streptococcus pyogenes. It cleaves the heavy chains of all human IgG subclasses (but no other immunoglobulins), eliminating Fc-dependent effector functions, including CDC and antibody-dependent cell-mediated cytotoxicity (ADCC). Thus,<unk>  reduces the level of donor specific antibodies, enabling transplantation. The benefits with<unk>  are its ability to convert a positive crossmatch to a negative one in highly sensitized people to allow renal transplantation. The most common side effects are infections and infusion related reactions.<unk>  was approved for medical use in the European Union in August 2020.
Imlifidase
Amidase
Disaccharidase
Iduronidase
Wobenzym
Biotinidase
Galactosylceramidase
Pegaspargase