<unk>  (GCCL) is a rare histological form of large-cell lung carcinoma, a subtype of undifferentiated lung cancer, traditionally classified within the non-small-cell lung carcinomas (NSCLC). The characteristic feature of this highly lethal malignancy is the distinctive light microscopic appearance of its extremely large<unk> s, which are bizarre and highly pleomorphic, and which often contain more than one huge, misshapen, pleomorphic nucleus ("syncytia"), which result from<unk>  fusion. Although it is common in the lung cancer literature to refer to histologically mixed tumors containing significant numbers of malignant<unk> <unk> s as<unk> -cell carcinomas", technically a diagnosis of<unk> -cell carcinoma" should be limited strictly to neoplasms containing only malignant<unk> <unk> s (i.e. "pure"<unk> -cell carcinoma). Aside from the great heterogeneity seen in lung cancers (especially those occurring among tobacco smokers), the considerable variability in diagnostic and sampling techniques used in medical practice, the high relative proportion of individuals with suspected GCCL who do not undergo complete surgical resection, and the near-universal lack of complete sectioning and pathological examination of resected tumor specimens prevent high levels of quantitative accuracy.
Giant-cell carcinoma of the lung
Mucinous cystadenocarcinoma of the lung
Sarcomatoid carcinoma of the lung
Epithelial-myoepithelial carcinoma of the lung
Pulmonary sclerosing pneumocytoma
Adenocarcinoma of the lung
Salivary gland–like carcinoma of the lung
Mesothelioma