<unk>  is inherited in an autosomal dominant pattern.<unk>  is inherited in an autosomal dominant pattern. In some cases, an affected person inherits the mutation from one affected parent. If a patient is shown to have<unk> , they have a 50/50 chance of passing it on to their children. Not all cases of<unk>  however is obvious. Other cases may result from new mutations in the gene. These cases occur in people with no history of the disorder in their family. A single mutation in the FGFR3 gene cause this syndrome. The FGFR3 gene provides instructions for making a protein that is involved in the development and maintenance of bone and brain tissue. This mutation causes the FGFR3 protein to be overly active, which interferes with normal bone growth and allows the bones of the skull to fuse before they should. As stated by researchers at the University of Washington,<unk>  is inherited in an autosomal dominant manner with incomplete penetrance and variable expressivity.” Prenatal diagnosis for pregnancies at increased risk is possible if the defining mutation has been identified in the family (Agochukwu et.al. 2006). According to the article Craniosynostosis: Molecular Genetics, penetrance is higher in females (87%) than in males (76%).<unk>  is estimated to account for 25%-30% of all genetic causes of craniosynostosis according to the Journal of Anatomy.
Muenke syndrome
Leschke syndrome
Zunich–Kaye syndrome
Eiken syndrome
Foster Kennedy syndrome
Cohen-Gibson syndrome
Baggio–Yoshinari syndrome
Scheie syndrome