The condition is typically diagnosed after noticing facial changes. The extent of disease may be seen using medical imaging such as CT scanning of the nose and sinus. Diagnosis can be confirmed by biopsy, microscopy, and culture. Histology reveals wide but thin-walled fungal filaments with branching at right-angles. There are only a few septae. The fungus is fragile and hence rarely isolated. An immunoallergic reaction might be observed, where a local antigen–antibody reaction causes eosinophils and hyaline material to surround the organism. Molecular methods may also be used to identify the fungus. Differential diagnosis Differential diagnosis includes soft tissue tumors. Other conditions that may appear similar include mucormycosis, cellulitis, rhinoscleroma and lymphoma.
Conidiobolomycosis
Soft-tissue sarcoma
Chromoblastomycosis
Basidiobolomycosis
Lobomycosis
Phycomycosis
Paracoccidioidomycosis
Actinomycosis