Hypersensitivity reactions occur in 1.4% of persons treated with<unk> , and can be fatal in medical settings with low resources. It is a form of severe cutaneous adverse reactions (SCARs) in which a SCARs disorder, primarily the DRESS syndrome or a DRESS syndrome-like reaction occurs. Blood Hemolysis is the most prominent side-effect, occurring in about 20 % of patients treated with<unk> , although it is dose-related. It may lead to hemolytic anemia and methemoglobinemia. The side-effect is more common and severe in those with glucose-6-phosphate dehydrogenase deficiency, leading to the<unk> -containing antimalarial combination Lapdap being withdrawn from clinical use. A case of hemolysis in a neonate from<unk>  in breast milk has been reported. Agranulocytosis occurs rarely when<unk>  is used alone but more frequently in combination regimens for malaria prophylaxis. Abnormalities in white blood cell formation, including aplastic anemia, are rare, yet are the cause of the majority of deaths attributable to<unk>  therapy. Methemoglobinemia occurs in about 15 % of patients treated with long-term<unk>  at standard doses (100 mg/day). Only special multi-wawelength oximeters (CO-oximeters) can detect methemoglobinemia directly. When there is a "saturation gap" between a low ordinary pulse oximeter reading and a high arterial blood gas analysis result, methemoglobinemia may be suspected. Liver Toxic hepatitis and cholestatic jaundice have been reported by the manufacturer. These toxic reactions may also occur as part of the<unk>  hypersensitivity syndrome (a form of SCARs-see above) or<unk>  syndrome (see below).<unk>  is metabolized by the Cytochrome P450 system, specifically isozymes CYP2D6, CYP2B6, CYP3A4, and CYP2C19.<unk>  metabolites produced by the cytochrome P450 2C19 isozyme are associated with the methemoglobinemia side effect of the drug. Skin When used topically,<unk>  can cause mild skin irritation, redness, dry skin, burning, and itching. When used together with benzoyl peroxide products, temporary yellow or orange skin discolorations can occur.<unk>  hypersensitivity syndrome Hypersensitivity reactions occur in some patients. This reaction may be more frequent in patients receiving multiple-drug therapy. The reaction always involves a rash, may also include fever, jaundice, and eosinophilia, and is likely to be one manifestation of the SCARs reaction viz., the DRESS syndrome (see above). In general, these symptoms will occur within the first six weeks of therapy or not at all, and may be ameliorated by corticosteroid therapy. Other adverse effects Other adverse effects include nausea, headache, and rash (which are common), and insomnia, psychosis, and peripheral neuropathy. Effects on the lung occur rarely and may be serious, though are generally reversible.
Dapsone
Terbinafine
Urodilatin
Fosravuconazole
Ketoconazole
Itraconazole
Cortistatin 
Miconazole