<unk>  <unk>  is a type of dementia characterized by changes in sleep, behavior, cognition, movement, and regulation of automatic bodily functions. Memory loss is not always an early symptom. The disease worsens over time and is usually diagnosed when cognitive impairment interferes with normal daily functioning. Together with Parkinson's disease dementia,<unk>  is one of the two Lewy body dementias. It is a common form of dementia, but the prevalence is not known accurately and many diagnoses are missed. The disease was first described by Kenji Kosaka in 1976. REM sleep behavior disorder (RBD)—in which people lose the muscle paralysis (atonia) that normally occurs during REM sleep and act out their dreams—is a core feature. RBD may appear years or decades before other symptoms. Other core features are visual hallucinations, marked fluctuations in attention or alertness, and parkinsonism (slowness of movement, trouble walking, or rigidity). A presumptive diagnosis can be made if several disease features are present, such as symptoms or certain results of blood tests, neuropsychological tests, imaging, and sleep studies. A definitive diagnosis usually requires an autopsy. Most people with<unk>  do not have affected family members, although occasionally<unk>  runs in a family. The exact cause is unknown but involves formation of abnormal clumps of protein in neurons throughout the brain. Manifesting as Lewy<unk>  (discovered in 1912 by Frederic Lewy) and Lewy neurites, these clumps affect both the central and the autonomic nervous systems. Heart function and every level of gastrointestinal function—from chewing to defecation—can be affected, constipation being one of the most common symptoms. Low blood pressure upon standing can also occur.<unk>  commonly causes psychiatric symptoms, such as altered behavior, depression, or apathy.<unk>  typically begins after the age of fifty, and people with the disease have a life expectancy of about four years after diagnosis. There is no cure or medication to stop the disease from progressing, and people in the latter stages of<unk>  may be unable to care for themselves. Treatments aim to relieve some of the symptoms and reduce the burden on caregivers. Medicines such as donepezil and rivastigmine can temporarily improve cognition and overall functioning, and melatonin can be used for sleep-related symptoms. Antipsychotics are usually avoided, even for hallucinations, because severe reactions occur in almost half of people with<unk> , and their use can result in death. Management of the many different symptoms is challenging, as it involves multiple specialties and education of caregivers.
Dementia with Lewy bodies
Parkinson's disease
Multiple system atrophy
Lewy body dementias
Subcortical dementia
Parkinson's disease dementia
Frontotemporal dementia
Vascular dementia