<unk>  overdose may result in stereotypical symptoms of benzodiazepine overdose including intoxication, impaired balance and slurred speech. In cases of severe overdose this may progress to a comatose state with the possibility of death. The risk of<unk>  overdose is increased significantly if<unk>  is abused in conjunction with opioids, as was highlighted in a review of deaths of users of the opioid buprenorphine. Nitrobenzodiazepines such as<unk>  can result in a severe neurological effects.<unk>  taken in overdose is associated with a high level of congenital abnormalities (30 percent of births). Most of the congentital abnormalities were mild deformities. Severe<unk>  overdose resulting in coma causes the central somatosensory conduction time (CCT) after median nerve stimulation to be prolonged and the N20 to be dispersed. Brain-stem auditory evoked potentials demonstrate delayed interpeak latencies (IPLs) I-III, III-V and I-V. Toxic overdoses therefore of<unk>  cause prolonged CCT and IPLs. An alpha pattern coma can be a feature of<unk>  overdose with alpha patterns being most prominent in the frontal and central regions of the brain. Benzodiazepines were implicated in 39% of suicides by drug poisoning in Sweden, with<unk>  and flunitrazepam accounting for 90% of benzodiazepine implicated suicides, in the elderly over a period of 2 decades. In three quarters of cases death was due to drowning, typically in the bath. Benzodiazepines were the predominant drug class in suicides in this review of Swedish death certificates. In 72% of the cases benzodiazepines were the only drug consumed. Benzodiazepines and in particular<unk>  and flunitrazepam should therefore be prescribed with caution in the elderly. In a brain sample of a fatal<unk>  poisoning high concentrations of<unk>  and its metabolite were found in the brain of the deceased person. In a retrospective study of deaths, when benzodiazepines were implicated in the deaths, the benzodiazepines<unk>  and flunitrazepam were the most common benzodiazepines involved. Benzodiazepines were a factor in all deaths related to drug addiction in this study of causes of deaths.<unk>  and flunitrazepam were significantly more commonly implicated in suicide related deaths than natural deaths. In four of the cases benzodiazepines alone were the only cause of death. In Australia,<unk>  and temazepam were the benzodiazepines most commonly detected in overdose drug related deaths. In a third of cases benzodiazepines were the sole cause of death. Individuals with chronic illnesses are much more vulnerable to lethal overdose with<unk> , as fatal overdoses can occur at relatively low doses in these individuals.
Nitrazepam
Avacopan
Atogepant
Bupranolol
Beclamide
Clonidine
Brimonidine
Tofisopam