Sleeping pills, including<unk> , have been associated with an increased risk of death. Hypersensitivity to<unk>  is a contra-indication to its use. Some side effects are more common than others. Recommendations around use of<unk>  may be altered by other health conditions. These conditions or circumstances may occur in people that have lowered metabolism and other conditions. The presence of liver impairment, lactation and activities requiring mental alertness (e.g., driving) may be considered when determining frequency and dosage. * unpleasant taste * headache * peripheral edema * chest pain * abnormal thinking * behavior changes * depression * hallucinations * sleep driving and sleepwalking * dry mouth * rash * altered sleep patterns * impaired coordination * dizziness * daytime drowsiness * itching * painful or frequent urination * back pain * aggressive behavior * confusion * agitation * suicidal thoughts * depersonalisation * amnesia A 2009 meta-analysis found a 44% higher rate of mild infections, such as pharyngitis or sinusitis, in people taking<unk>  or other hypnotic drugs compared to those taking a placebo. Dependence In the United States<unk>  is a schedule IV controlled substance under the Controlled Substances Act. Use of<unk>  may lead to physical and psychological dependence. The risk of non-medical use and dependence increases with the dose and duration of usage and concomitant use of other psychoactive substances. The risk is also greater in patients with a history of alcohol use disorder or other substance use disorder or history of psychiatric disorders. Tolerance may develop after repeated use of benzodiazepines and benzodiazepine-like drugs for a few weeks. A study funded and carried out by Sepracor, the manufacturer of<unk> , found no signs of tolerance or dependence in a group of patients followed for up to six months. Non-medical use A study of non-medical use potential of<unk>  found that in persons with a known history of non-medical benzodiazepine use,<unk>  at doses of 6 and 12 mg produced effects similar to those of diazepam 20 mg. The study found that at these doses which are two or more times greater than the maximum recommended doses, a dose-related increase in reports of amnesia, sedation, sleepiness, and hallucinations was observed for both<unk>  (Lunesta) as well as for diazepam (Valium). Overdose According to the U.S. Prescribing Information, overdoses of<unk>  up to 90 times the recommended dose have been reported in which the patient fully recovered. According to the May 2014 edition of the official U.S. Prescribing Information, fatalities have been reported only in cases in which<unk>  was combined with other drugs or alcohol. Poison control centers reported that between 2005 and 2006 there were 525 total<unk>  overdoses recorded in the state of Texas, the majority of which were intentional suicide attempts. If consumed within the last hour,<unk>  overdose can be treated with the administration of activated charcoal or via gastric lavage. Interactions There is an increased risk of central nervous system depression when<unk>  is taken together with other CNS depressant agents, including antipsychotics, sedative hypnotics (like barbiturates or benzodiazepines), antihistamines, opioids, phenothiazines, and some antidepressants. There is also increased risk of central nervous system depression with other medications that inhibit the metabolic activities of the CYP3A4 enzyme system of the liver. Medications that inhibit this enzyme system include nelfinavir, ritonavir, ketoconazole, itraconazole and clarithromycin. Alcohol also has an additive effect when used concurrently with<unk> .<unk>  is most effective if it is not taken after a heavy meal with high fat content.
Eszopiclone
Zopiclone
Chloropicrin
Eliglustat
Hydrastine
Mometasone
Flumetasone
Clobetasone