<unk>  Site Ki (nM) Species Ref 5-HT1A 5,888 Human 5-HT2A 7.24 Human 5-HT2C 123 Human 5-HT3 1349 Human 5-HT6 148 Human 5-HT7 6,760 Human α1 24 Human α2 1700 Human M1 776 Human M2 1413 Human D1 251 Human D2 2.24 Human D3 1.82 Human D4 5.37 Human H1 6.03 Human H3 17,378 Human H4 17783 Human DAT 589 Human NET 600 Rat<unk>  is thought to exert its antipsychotic effects by blocking dopamine receptors.<unk>  is analogous to chlorpromazine; both of these agents antagonize dopaminergic D2 receptors in various pathways of the central nervous system. This D2 blockade results in antipsychotic, antiemetic and other effects. Hyperprolactinemia is a side effect of dopamine antagonists as blockade of D2 receptors within the tuberoinfundibular pathway results in increased plasma levels of prolactin due to increased secretion by lactotrophs in the anterior pituitary. Following intramuscular injection, the antiemetic action is evident within 5 to 10 minutes and lasts for 3 to 4 hours. Rapid action is also noted after buccal treatment. With oral dosing, the start of action is delayed but the duration somewhat longer (approximately 6 hours).
Prochlorperazine
Ethacizine
Misoprostol
Salicylic acid
Ioxaglic acid
Loperamide
Trifluoperazine
Sakacin