There is no cure for<unk> , but there are a number of medicines to help treat the symptoms: Anti-mediator therapy * Antihistamines block receptors targeted by histamine released from mast cells. Both H1 and H2 blockers may be helpful, often in combination. * Leukotriene antagonists block receptors targeted by leukotrienes released from mast cells. * Mast cell stabilizers help prevent mast cells from releasing their chemical contents. Cromoglicic acid is the only medicine specifically approved by the FDA for the treatment of<unk> . Ketotifen is available in Canada and Europe and more recently in the U.S. It is also available as eyedrops (Zaditor). * Proton-pump inhibitors help reduce production of gastric acid, which is often increased in patients with<unk> . Excess gastric acid can harm the stomach, esophagus, and small intestine. * Epinephrine constricts blood vessels and opens airways to maintain adequate circulation and ventilation when excessive mast cell degranulation has caused anaphylaxis. * Salbutamol and other beta-2 agonists open airways that can constrict in the presence of histamine. * Corticosteroids can be used topically, inhaled, or systemically to reduce inflammation associated with<unk> . * Drugs to prevent/treat osteoporosis include Calcium-Vitamine D, bisphosphonates and in rare cases inhibitors of RANK-L Antidepressants are an important and often overlooked tool in the treatment of<unk> . Depression and other neurological symptoms have been noted in<unk> . Some antidepressants, such as doxepin and mirtazapine, are themselves potent antihistamines and can help relieve physical as well as cognitive symptoms. Cytoreductive therapy In cases of advanced systemic<unk>  or rare cases with indolent systemic<unk>  with very troublesome symptoms, cytoreductive therapy can be indicated. * ɑ-interferon. Given as subcutaneous injections. Side effects include fatigue and influenza-like symptoms * Cladribine (CdA). Chemotherapy which is given as subcutaneous injections. Side effects include immunodeficiency and infections. * Tyrosine kinase inhibitors (TKI) * Midostaurin. TKI acting on many different tyrosine kinases, approved by FDA and EMA for advanced<unk>  * Imatinib. Can have effect in rare cases without mutation in KIT(D816V) * Masitinib. Is being tested in trials. Not approved. * Midostaurin - 60% respond. * Avapritinib in trials; currently being tested but showing promise in reduction of tryptase levels. Allogeneic stem cell transplantation has been used in rare cases with aggressive systemic<unk>  in patients deemed to be fit for the procedure. Other Treatment with ultraviolet light can relieve skin symptoms, but may increase the risk of skin cancer.
Mastocytosis
Monocytosis
Plasmacytosis
Lymphocytosis
Neutropenia
Macrocytosis
Neuroacanthocytosis
Neutrophilia