There exist numerous treatments for nail psoriasis but there is little information concerning their effectiveness and safety. Treatments include topical, intralesional, radiation, systemic, and combination therapies. * Tacalcitol ointment obtains a significant improvement in all nail parameters, both of the matrix and of the bed. * Clobetasol nail lacquer and tacalcitol ointment * 5-fluorouracil. A reported side-effect is yellow nails * Calcipotriol * Calcipotriol plus betamethasone dipropionate ointment. * Efalizumab * Infliximab * Golimumab * Low dose methotrexate * Intralesional corticosteroid injection Relative effectiveness of treatments Available studies lack sufficient power to extrapolate a standardized therapeutic regimen. As of April 2009, an assessment of the evidence for the efficacy and safety of the treatments for nail psoriasis is in progress. * Infliximab appears to be the most effective treatment for nail psoriasis to date. * Results from low-dose acitretin therapy show NAPSI score reductions comparable with those studies evaluating biologic drugs for nail psoriasis and suggest that low-dose systemic acitretin should be considered in the treatment of nail psoriasis. A 2013 meta-analysis showed improvement of nail psoriasis with infliximab, golimumab, superficial radiotherapy, electron beam, and grenz rays compared to placebo. Although systemic therapies have been shown to be beneficial, they may have serious adverse effects. Topical treatments have not been well studied but may be beneficial.
Psoriatic onychodystrophy
Onychomycosis
Onychogryphosis
Median nail dystrophy
Dysplastic nail
Onychophosis
Hypertrichosis cubiti
Exudative hyponychial dermatitis