Enlarged spleen due to<unk> ; CT scan coronal section, spleen in red, left kidney in green Signs and symptoms are nonspecific and generally related to the blood cytopenias: * Anemia (low RBC count or reduced hemoglobin) – chronic tiredness, shortness of breath, chilled sensation, sometimes chest pain * Neutropenia (low neutrophil count) – increased susceptibility to infection * Thrombocytopenia (low platelet count) – increased susceptibility to bleeding and ecchymosis (bruising), as well as subcutaneous hemorrhaging resulting in purpura or petechiae Many individuals are asymptomatic, and blood cytopenia or other problems are identified as a part of a routine blood count: * Neutropenia, anemia, and thrombocytopenia * Splenomegaly or rarely hepatomegaly * Abnormal granules in cells, abnormal nuclear shape and size * Chromosome abnormality, including chromosomal translocations and abnormal chromosome number Although some risk exists for developing acute myelogenous leukemia, about 50% of deaths occur as a result of bleeding or infection. However, leukemia that occurs as a result of myelodysplasia is notoriously resistant to treatment. Anemia dominates the early course. Most symptomatic patients complain of the gradual onset of fatigue and weakness, dyspnea, and pallor, but at least half the patients are asymptomatic and their<unk>  is discovered only incidentally on routine blood counts. Previous chemotherapy or radiation exposure is an important factor in the person's medical history. Fever, weight loss and splenomegaly should point to a<unk> /myeloproliferative neoplasm <unk> /MPN) rather than pure<unk>  process.
Myelodysplastic syndrome
Primary myelofibrosis
Acute myeloid leukemia
Myeloid leukemia
Autoimmune neutropenia
Mixed-phenotype acute leukemia
Childhood leukemia
B-cell leukemia