There are two types of SGBS, each found on a different gene: Type OMIM Gene Locus SGBS1 GPC3 Xq26 SGBS2 OFD1 Xp22 SGBS is also considered to be an overgrowth syndrome (OGS). OGS is characterized by a 2-3 standard deviation increase in weight, height, or head circumference above the average for sex and age. One of the most noted features of OGS is the increased risk of neoplasms in certain OGSs. SGBS in particular has been found to have a 10% tumor predisposition frequency with 94% of cases occurring in the abdominal region, most being malignant. It is common for tumors to be embryonal in type and appear before the age of 10. There are five different types of tumors that patients with SGBS might develop, all intra-abdominal: Wilms tumor, Hepatoblastoma, Hepatocarcinoma, Gonadoblastoma, and Neuroblastoma. The most common types of tumors developed in patients are the Wilms tumor and hepatoblastoma.
Simpson–Golabi–Behmel syndrome
Li–Fraumeni syndrome
Weismann-Netter–Stuhl syndrome
Maroteaux–Lamy syndrome
Kufor–Rakeb syndrome
Daentl Townsend Siegel syndrome
Dennie–Marfan syndrome
Smith–Lemli–Opitz syndrome