A<unk> <unk> , also termed<unk>  diffuse large B-cell<unk>  of the central<unk><unk> , is a<unk>  intracranial tumor appearing mostly in patients with severe immunodeficiency (typically patients with AIDS). It is a subtype and one of the most aggressive of the diffuse large B-cell<unk> s.<unk> s represent around 20% of all cases of<unk> s in HIV infections. (Other types are Burkitt's<unk> s and immunoblastic<unk> s).<unk>  is highly associated with Epstein-Barr virus (EBV) infection (> 90%) in immunodeficient patients (such as those with AIDS and those immunosuppressed), and does not have a predilection for any particular age group. Mean CD4+ count at time of diagnosis is ~50/uL. In immunocompromised patients, prognosis is usually poor. In immunocompetent patients (that is, patients who do not have AIDS or some other immunodeficiency), there is rarely an association with EBV infection or other DNA viruses. In the immunocompetent population,<unk> s typically appear in older patients in their 50s and 60s. Importantly, the incidence of<unk>  in the immunocompetent population has been reported to have increased more than 10-fold from 2.5 cases to 30 cases per 10 million population. The cause for the increase in incidence of this disease in the immunocompetent population is unknown.
Primary central nervous system lymphoma
Malignant multiple sclerosis
Lymphocytic meningoradiculitis
Leptomeningeal cancer
Brainstem glioma
Brain metastasis
Central nervous system cavernous hemangioma
Autoimmune encephalitis