The management of<unk>  centers on the early detection and prevention of cancer types that are known to occur as part of this syndrome. Specific screening guidelines for<unk>  patients have been published by the National Comprehensive Cancer Network (NCCN). Surveillance focuses on the early detection of breast, endometrial, thyroid, colorectal, renal, and skin cancer. See below for a complete list of recommendations from the NCCN: + Screening guidelines for patients with<unk>  (adapted from the NCCN) Women Men and Women Breast awareness starting at age 18 years of age Annual comprehensive physical exam starting at 18 years of age or 5 years before the youngest age of diagnosis of a component cancer in the family (whichever comes first), with particular attention to breast and thyroid exam Clinical breast exam, every 6–12 month, starting at age 25 y or 5–10 y before the earliest known breast cancer in the family Annual thyroid starting at age 18 y or 5–10 y before the earliest known thyroid cancer in the family, whichever is earlier Annual mammography and breast MRI screening starting at age 30–35 y or individualized based on earliest age of onset in family Colonoscopy, starting at age 35 y, then every 5 y or more frequently if patient is symptomatic or polyps found For endometrial cancer screening, encourage patient education and prompt response to symptoms and participation in a clinical trial to determine the effectiveness or necessity of screening modalities Consider renal ultrasound starting at age 40 y, then every 1–2 y Discuss risk-reducing mastectomy and hysterectomy and counsel regarding degree of protection, extent of cancer risk and reconstruction options Dermatological management may be indicated for some patients Address psychosocial, social, and quality-of-life aspects of undergoing risk-reducing mastectomy and/or hysterectomy Consider psychomotor assessment in children at diagnosis and brain MRI if there are symptoms Education regarding the signs and symptoms of cancer
Cowden syndrome
Juvenile polyp
Laron syndrome
Fox–Fordyce disease
Jervell and Lange-Nielsen syndrome
Danon disease
Pott disease
Scott syndrome