The exact mechanism of<unk>  is not clear. Inappropriate response of stem cells in the bone against the injury or inflammation causes inappropriate differentiation of fibroblasts into osteogenic cells. When a skeletal muscle is injured, inflammatory cytokines (Bone<unk> rphogenetic protein 2, Bone<unk> rphogenetic protein 4, and Transforming growth factor) are released. These cytokines stimulate the endothelial cells of the blood vessels to transform into mesenchymal stem cells. These mesenchymal stem cells then differentiate into chondrocytes, and osteoblasts, resulting in bone formation in soft tissues. The process of<unk>  can be divided into three stages: early, intermediate, and mature. The early phase occurs in the first four weeks of injury with inflammatory phase of bone formation. This is followed by intermediate phase of bone formation (four to eight weeks following injury) where calcification started to occur and is visible on X-rays. During the maturation phase, mature bone started to form. As the maturation continues, the bone will consolidate in the coming<unk> nths and subsequently bone regression occurs.
Myositis ossificans
Osteoma cutis
Fibrodysplasia ossificans progressiva
Leri pleonosteosis
Osteitis fibrosa cystica
Osteochondritis dissecans
Enchondromatosis
Osteofibrous dysplasia