The substance is metabolised by the liver enzyme CYP3A4. In a study, the strong CYP3A4 inhibitor ketoconazole increased the maximal blood plasma concentrations of<unk>  by a factor of eight, and the area under the curve by a factor of 15. In another study, ciclosporin increased<unk>  plasma levels threefold when given at the same time. Other inhibitors of this enzyme, such as itraconazole, erythromycin, and grapefruit juice, are also expected to increase plasma concentrations and thus amplify the antihypertensive effect. Conversely, CYP3A4 inductors such as carbamazepine, rifampicin, and St John's wort probably lower plasma levels and effectiveness of<unk> . By comparison, amlodipine has a lower potential for CYP3A4 mediated interactions.<unk>  increases plasma levels of ciclosporin and digoxin.
Lercanidipine
Lacidipine
Clevidipine
Nimodipine
Stanozolol
Metaraminol
Labetalol
Metandienone