Mechanism of action The drug inhibits enzymes called metalloproteinases. In lice, these enzymes play a role in egg development and survival; and consequently, blocking them will disrupt the lice's life cycle. Pharmacokinetics After application to the scalp, part of the substance reaches the bloodstream, where most of it (91.3–92.3%) is bound to plasma proteins. It is metabolized primarily by the liver enzyme CYP1A2 to<unk>  hydroxyl and further to<unk>  carboxyl (see structure drawings).<unk>  carboxyl has a plasma protein binding of 96.0–97.5% and is the predominant of the three substances in the circulation, having a Cmax 30 times and an area under the curve (AUC) 250 times that of<unk>  itself. The elimination half-life of<unk>  is 21 hours. That of<unk>  carboxyl is not well known; it is thought to be 71±40 hours or longer. It is not known whether the drug is eliminated via the urine or the faeces. The drug's metabolites in humans:<unk>  hydroxyl (left) and<unk>  carboxyl (right)
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