If there is a<unk>  in the septum, it is possible for blood to travel from the left side of the heart to the right side of the heart, or the other way around. Since the right side of the heart contains venous blood with a low oxygen content, and the left side of the heart contains arterial blood with a high oxygen content, it is beneficial to prevent any communication between the two sides of the heart and prevent the blood from the two sides of the heart from mixing with each other. 190px Genetic Relationship TBX2 is a T-box transcription factor and is usually expressed during various areas of embryogenesis. One notable expression is when it is shown in the development of the outflow system and<unk>  canal of the developing heart. In a study, they used targeted mutagenesis in mice to delete Tbx2 locus in some specimen. The results showed that mice who were homozygous and heterozygous null (+/+ & +/-) for Tbx2 resulted in the development of a healthier heart, while those who were homozygous null (-/-) for Tbx2 died early because of the inability of the heart to supply the body. It showed that there was insufficient formation of the endocardial cushion. There was a clear abnormality not only in the<unk>  canal but also in the left ventricle. This study supports the fact that Tbx2 expression is important in the development of proper chamber differentiation, and in turn cannot have a direct relation to the development of<unk>  canal<unk> .
Atrioventricular septal defect
Atrial septal defect
Ventricular septal defect
Double inlet left ventricle
Persistent truncus arteriosus
Heart septal defect
Sinus venosus atrial septal defect
Tricuspid atresia