<unk>  is a portion of human parathyroid hormone (PTH), amino acid sequence 1 through 34, of the complete molecule (containing 84 amino acids). Endogenous PTH is the primary regulator of calcium and phosphate metabolism in bone and kidney. PTH increases serum calcium, partially accomplishing this by increasing bone resorption. Thus, chronically elevated PTH will deplete bone stores. However, intermittent exposure to PTH will activate osteoblasts more than osteoclasts. Thus, once-daily injections of<unk>  have a net effect of stimulating new bone formation leading to increased bone mineral density.<unk>  is the first FDA approved agent for the treatment of osteoporosis that stimulates new bone formation.
Teriparatide
Denosumab
Bolazine capronate
Zoledronic acid
Medronic acid
Alendronic acid
Risedronic acid
Ibandronic acid