The clinical definition of ordinary<unk>  is an illness with acute onset of fever equal to or greater than followed by a rash characterized by firm, deep-seated vesicles or pustules in the same stage of development without other apparent cause. When a clinical case was observed,<unk>  was confirmed using laboratory tests. Microscopically, poxviruses produce characteristic cytoplasmic inclusion bodies, the most important of which are known as Guarnieri bodies, and are the sites of viral replication. Guarnieri bodies are readily identified in skin biopsies stained with hematoxylin and eosin, and appear as pink blobs. They are found in virtually all poxvirus infections but the absence of Guarnieri bodies could not be used to rule out<unk> . The diagnosis of an orthopoxvirus infection can also be made rapidly by electron microscopic examination of pustular fluid or scabs. All orthopoxviruses exhibit identical brick-shaped virions by electron microscopy. If particles with the characteristic morphology of herpesviruses are seen this will eliminate<unk>  and other orthopoxvirus infections. Definitive laboratory identification of Variola virus involved growing the virus on chorioallantoic membrane (part of a chicken embryo) and examining the resulting pock lesions under defined temperature conditions. Strains were characterized by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Serologic tests and enzyme linked immunosorbent assays (ELISA), which measured Variola virus-specific immunoglobulin and antigen were also developed to assist in the diagnosis of infection. Chickenpox was commonly confused with<unk>  in the immediate post-eradication era. Chickenpox and<unk>  could be distinguished by several methods. Unlike<unk> , chickenpox does not usually affect the palms and soles. Additionally, chickenpox pustules are of varying size due to variations in the timing of pustule eruption:<unk>  pustules are all very nearly the same size since the viral effect progresses more uniformly. A variety of laboratory methods were available for detecting chickenpox in the evaluation of suspected<unk>  cases. File:Smallpox CAM.Smallpox virus lesions on the chorioallantoic membrane of a developing chick. File:Smallpox versus chickenpox english plain.In contrast to the rash in<unk> , the rash in chickenpox occurs mostly on the torso, spreading less to the limbs. File:Female<unk>  patient -- late-stage confluent maculopapular scarring.An Italian female<unk>  patient whose skin displayed the characteristics of late-stage confluent maculopapular scarring, 1965.
Smallpox
Monkeypox
Cowpox
Impetigo
Chickenpox
Sealpox
Molluscum contagiosum
Mumps