Up to 20% of people taking<unk>  experience peripheral neuropathy when taking doses of 6 mg/kg of weight daily or higher. Gastrointestinal reactions include nausea and vomiting. Aplastic anemia, thrombocytopenia, and agranulocytosis due to lack of production of red blood cells, platelets, and white blood cells by the bone marrow respectively, can also occur. Hypersensitivity reactions are also common and can present with a maculopapular rash and fever. Gynecomastia may occur. Asymptomatic elevation of serum liver enzyme concentrations occurs in 10% to 20% of people taking<unk> , and liver enzyme concentrations usually return to normal even when treatment is continued.<unk>  has a boxed warning for severe and sometimes fatal hepatitis, which is age-dependent at a rate of 0.3% in people 21 to 35 years old and over 2% in those over age 50. Symptoms suggestive of liver toxicity include nausea, vomiting, abdominal pain, dark urine, right upper quadrant pain, and loss of appetite. Black and Hispanic women are at higher risk for<unk> -induced hepatotoxicity. When it happens,<unk> -induced liver toxicity has been shown to occur in 50% of patients within the first 2 months of therapy. Some recommend that liver function should be monitored carefully in all people receiving it, but others recommend monitoring only in certain populations. Headache, poor concentration, weight gain, poor memory, insomnia, and depression have all been associated with<unk>  use. All patients and healthcare workers should be aware of these serious side effects, especially if suicidal ideation or behavior are suspected.<unk>  is associated with pyridoxine (vitamin B6) deficiency because of its similar structure.<unk>  is also associated with increased excretion of pyridoxine. Pyridoxal phosphate (a derivative of pyridoxine) is required for δ-aminolevulinic acid synthase, the enzyme responsible for the rate-limiting step in heme synthesis. Therefore,<unk> -induced pyridoxine deficiency causes insufficient heme formation in early red blood cells, leading to sideroblastic anemia.<unk>  was found to significantly elevate the in vivo concentration of GABA and homocarnosine in a single subject via magnetic resonance spectroscopy.
Isoniazid
Ethambutol
Pyrazinamide
Safinamide
Ipriflavone
Pingyangmycin
Oxepanoprolinamide
Miproxifene