The<unk>  is an in vivo test to screen for substances that cause human skin sensitisation (i.e. allergens). It was first proposed by Edwin Vernon<unk>  in 1965 and further explained in 1980. It is a non-adjuvant test. In the test, Guinea pigs are exposed to a high dose of the substance. They are then given a challenge dose, which is the highest dose that does not cause irritation. The test has been largely superseded by the murine local lymph node assay.
Buehler test
Lancaster red-green test
Vinegar test
Elek's test
Bourne test
Rinne test
Thompson test
Heaf test