Disruption of normal microbiome There are an estimated 38 trillion microorganisms that colonize the human body. As a side-effect of therapy, antibiotics can change the body's normal microbial content by attacking indiscriminately both the pathological and naturally occurring, beneficial or harmless bacteria found in the intestines, lungs and bladder. The destruction of the body's normal bacterial flora is thought to disrupt immunity, nutrition, and lead to a relative overgrowth in some bacteria or fungi. An overgrowth of drug-resistant microorganisms can lead to a secondary infection such as Clostridioides difficile ("C. diff") or candidiasis ("thrush"). This side-effect is more likely with the use of<unk> s, given their greater potential to disrupt a larger variety of normal human flora. The use of doxycycline in acne vulgaris has been associated with increased risk of Crohn's disease. Likewise, the use of minocycline in acne vulgaris has been associated with skin and gut dysbiosis.
Broad-spectrum antibiotic
Antibiotic
Steroid
Beta-lactam antibiotics
Combination antibiotic
Antimicrobial
Neuromuscular blocking agents
Antiseptic