<unk>  is caused by a genetic mutation that prevents the formation of nerve cells which are responsible for transmitting signals of<unk> , heat, and cold to the brain. The disorder is inherited in an autosomal recessive fashion.<unk>  is caused by a mutation in NTRK1, a gene encoding the neurotrophic tyrosine kinase receptor. NTRK1 is a receptor for nerve growth factor (NGF). This protein induces outgrowth of axons and dendrites and promotes the survival of embryonic sensory and sympathetic neurons. The mutation in NTRK1 does not allow NGF to bind properly, causing defects in the development and function of nociceptive reception. Mitochondrial abnormalities in muscle cells have been found in people with<unk> . Skin biopsies show a lack of innervation of the eccrine glands and nerve biopsies show a lack of small myelinated and unmyelinated fibers.
Congenital insensitivity to pain with anhidrosis
Monomelic amyotrophy
Stiff skin syndrome
Dorian Gray syndrome
Cramp fasciculation syndrome
Locked-in syndrome
Hunan hand syndrome
Benign fasciculation syndrome