When a person appears to have a<unk> , the main components of a workup (for determining the appropriate therapy and the person's prognosis) are: * Establishing the precise subtype: Initially, an incisional or excisional biopsy is preferred. A core needle biopsy is discouraged except in case a lymph node is not easily accessible. Fine-needle aspiration is only acceptable in selected circumstances, in combination with immunohistochemistry and flow cytometry. * Determining the extent of the disease (localized or advanced; nodal or extranodal) * The person's general health status. + Main immunohistochemistry markers in common types of<unk> . Follicular<unk>  Marginal zone<unk>  (MZL) or mucosa-associated lymphatic tissue (MALT)<unk>  Small lymphocytic<unk>  (SLL) / chronic lymphocytic leukemia (CLL) Mantle<unk><unk>  (MCL) CD5 - - + + CD10 + - - - CD23 - - + - Cyclin D1 - - - +
B-cell lymphoma
Non-Hodgkin lymphoma
Hodgkin lymphoma
T-cell lymphoma
Aggressive lymphoma
Mixed-cell lymphoma
AIDS-related lymphoma
Burkitt lymphoma