Most patients with classic<unk>  carry bialletic loss-of-function mutations of transmembrane channel-like protein 6 (TMC6; also called<unk>  protein 1,<unk> ER1), TMC8 (also called<unk> ER2), or calcium- and integrin-binding protein 1 (CIB1). The<unk> ER1 or<unk> ER2 genes are located adjacent to one another on chromosome 17. These genes play a role in regulating the distribution of zinc in the cell nuclei. Zinc is a necessary cofactor for many viral proteins, and the activity of<unk> ER1/EVER2 complex appears to restrict the access of viral proteins to cellular zinc stores, limiting their growth. Other genes have also rarely been associated with this condition. These include the ras homolog gene family member H.
Epidermodysplasia verruciformis
Keratosis pilaris
Dermatosis neglecta
Nevus depigmentosus
Erythrokeratodermia variabilis
Nevus lipomatosus superficialis
Linitis plastica
Tinea imbricata