<unk>  is characterized by both: # At least a single sebaceous gland tumor (either an adenoma, an epithelioma, or a carcinoma) # A minimum of one internal malignancy The Amsterdam criteria are frequently used to diagnose Lynch syndrome and<unk> . They include the following: * 3 or more relatives with an HNPCC-associated cancer (i.e., colorectal, cancer of the endometrium, small bowel, ureter, or renal pelvis) * 2 or more successive generations affected by cancer * 1 or more persons with cancer is a first-degree relative of the other 2, at least 1 case of colorectal cancer younger than age 50 years, a diagnosis of familial adenomatous polyposis has been excluded, tumors are verified by histologic examination<unk>  is a genetic condition. Mutations in MLH1 and MSH2 are linked with the disease. These genes code for DNA mismatch repair genes, and mutations increase the risk of developing cancerous qualities. Many patients who have sebaceous neoplasms with mutations in MSH2 and MLH1 do not in fact have<unk> . The Mayo<unk><unk>  risk score was devised to improve the positive predictive value of immunohistochemistry and reduce the false positive rate. The Mayo<unk><unk>  Risk score assigns points based several characteristics. A score of 2 or greater has a high positive predictive value of<unk> . A score of 1 or lower is less likely to be<unk> . Age of onset of first sebaceous neoplasm: 2 = 2 points. Personal history of Lynch related cancers: No = 0 points, Yes = 1 point Family history of Lynch-related cancer: No = 0 points, Yes = 1 point The most common internal malignancies associated with<unk>  are: Colorectal (56%), Urogenital (22%), Small Intestine (4%), and Breast (4%). A variety of other internal malignancies have been reported.
Muir–Torre syndrome
Galloway Mowat syndrome
Binder's syndrome
Gómez–López-Hernández syndrome
Zieve's syndrome
Mungan syndrome
Rosselli–Gulienetti syndrome
Löffler's syndrome