<unk> <unk> s been FDA-approved to treat osteoarthritis of the knee via intra-articular injection. A 2012 review showed that the quality of studies supporting this use was mostly poor, with a general absence of significant benefits, and that intra-articular injection of<unk>  could possibly cause adverse effects. A 2020 meta-analysis found that intra-articular injection of high molecular weight<unk>  improved both pain and function in people with knee osteoarthritis.<unk> <unk> s been used in various formulations to create artificial tears to treat dry eye.<unk>  is a common ingredient in skin care products.<unk>  is used as a dermal filler in cosmetic surgery. It is typically injected using either a classic sharp hypodermic needle or a micro-cannula. Some studies<unk> ve suggested that the use of micro-cannulas can significantly reduce vessel embolisms during injections. Currently,<unk>  is used frequently as a soft tissue filler due to its bio-compatibility and reversibility. Complications include the severing of nerves and microvessels, pain, and bruising. Some side effects can also appear by way of erythema, itching, and vascular occlusion; vascular occlusion is the most worrisome side effect due to the possibility of skin necrosis, or even blindness in a patient. In some cases,<unk>  fillers can result in a granulomatous foreign body reaction.
Hyaluronic acid
Polysulfated glycosaminoglycan
Cerebroside
Glucuronic acid
Lecithin
Hippulin
Pentosan polysulfate
Chaperone 