HAE is caused by a mutation of the C1-inhibitor gene. Defective or missing C1-inhibitor permits activation of kallikrein, a protease that is responsible for liberating bradykinin from its precursor kininogen. An excess of bradykinin leads to fluid leakage from blood vessels, causing swelling of tissues typical of HAE.<unk>  suppresses this pathogenetic mechanism by selectively and reversibly inhibiting the activity of plasma kallikrein.<unk> 's inhibitory constant (Ki) for kallikrein is 25 picoMolar, indicating high affinity.
Ecallantide
Ciclopirox
Crofelemer
Chlordecone
Argyrol
Cafaminol
Tisagenlecleucel
Clinatec