Copper deposition on corneal Descemet's membrane The<unk> s, which consist of copper deposits where the cornea meets the sclera, in Descemet's membrane, first appear as a crescent at the top of the cornea. Eventually, a second crescent forms below, at the "six o'clock position", and ultimately completely encircles the cornea. Associations<unk> s are a sign of Wilson's disease, which involves abnormal copper handling by the liver resulting in copper accumulation in the body and is characterised by abnormalities of the basal ganglia of the brain, liver cirrhosis, splenomegaly, involuntary movements, muscle rigidity, psychiatric disturbances, dystonia and dysphagia. The combination of neurological symptoms, a low blood ceruloplasmin level and KF<unk> s is diagnostic of Wilson's disease. Other causes of KF<unk> s are cholestasis (obstruction of the bile ducts), primary biliary cirrhosis and "cryptogenic" cirrhosis (cirrhosis in which no cause can be identified).
Kayser–Fleischer ring
Rey–Osterrieth complex figure
Sorsby's fundus dystrophy
Forchheimer spots
Hutchinson's pupil
Nagayama's spots
Koplik's spots
Bitot's spots