Digital clubbing with cyanotic nail beds in an adult with tetralogy of Fallot Signs and symptoms are related to type and severity of the<unk><unk> . Symptoms frequently present early in life, but it is possible for some<unk> s to go undetected throughout life. Some children have no signs while others may exhibit shortness of breath, cyanosis, fainting,<unk>  murmur, under-development of limbs and muscles, poor feeding or growth, or respiratory infections.<unk> s cause abnormal<unk>  structure resulting in production of certain sounds called<unk>  murmur. These can sometimes be<unk> ed by auscultation; however, not all<unk>  murmurs are caused by<unk> s. Associated conditions<unk> s are associated with an increased incidence of seven other specific medical conditions, together being called the VACTERL association: * V — Vertebral anomalies * A — Anal atresia * C — Cardiovascular anomalies * T — Tracheoesophageal fistula * E — Esophageal atresia * R — Renal (Kidney) and/or radial anomalies * L — Limb<unk> s Ventricular septal<unk>  (VSD), atrial septal<unk> s, and tetralogy of Fallot are the most common<unk> s seen in the VACTERL association. Less common<unk> s in the association are truncus arteriosus and transposition of the great arteries.
Congenital heart defect
Musculoskeletal abnormality
Neuromuscular disease
Vascular anomaly
Genetic disorder
Brain damage
Neuromuscular junction disease
Musculoskeletal injury