A<unk>  is caused by the progressive loss of structure or function of neurons, in the process known as neurodegeneration. Such neuronal damage may ultimately involve cell death.<unk> s include amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Alzheimer's disease, Huntington's disease, multiple system atrophy, and prion diseases. Neurodegeneration can be found in the brain at many different levels of neuronal circuitry, ranging from molecular to systemic. Because there is no known way to reverse the progressive degeneration of neurons, these diseases are considered to be incurable; however research has shown that the two major contributing factors to neurodegeneration are oxidative stress and inflammation. Biomedical research has revealed many similarities between these diseases at the subcellular level, including atypical protein assemblies (like proteinopathy) and induced cell death. These similarities suggest that therapeutic advances against one<unk>  might ameliorate other diseases as well. It is estimated that 50 million people worldwide suffer from<unk> s, and that by 2050 this figure will increase to 115 million people.
Neurodegenerative disease
Basal ganglia disease
Demyelinating disease
Degenerative disease
Neurocristopathy
Spinal disease
Psychogenic disease
Neurolathyrism