The<unk><unk><unk>  (TNF)<unk>  is a protein<unk>  of type II transmembrane proteins containing TNF homology domain and forming trimers. Members of this<unk>  can be released from the cell membrane by extracellular proteolytic cleavage and function as a cytokine. These proteins are expressed predominantly by immune cells and they regulate diverse cell functions, including immune response and inflammation, but also proliferation, differentiation, apoptosis and embryogenesis. The<unk>  contains 19 members that bind to 29 members of TNF receptor<unk> . An occurrence of orthologs in invertebrates hints at ancient origin of this<unk>  in evolution. The PROSITE pattern of this<unk>  is located in a beta sheet in the central section of the protein that is conserved across all members.
Tumor necrosis factor superfamily
Thromboxane receptor
Fc receptor-like molecule
Type I cytokine receptor
Type II cytokine receptor
Fc receptor
Interleukin-7 receptor
Complement receptor 1