The signs and symptoms that are present vary with each individual as some may have all symptoms while some may only have some listed below. However, the progression of this disease is different with each individual which reflects how the symptoms change over time. Further, the damage that we see to the myelin and axons is thought to contribute to many of the neurological signs and symptoms that are shown in this condition. The most frequent symptoms are categorized into psychiatric, psychotic and neurologic. +Predominant Symptoms Based on Category Category Symptoms Psychiatric Depression, Anxiety, Alcohol use disorder, Irritability, and Aggressiveness Psychotic Confusion, Delusions, and Hallucinations Neurologic Dementia, Seizures, Impaired Balance, Retropulsion, Gait Apraxia, Spasticity, Ataxia, and Urinary Incontinence General Symptoms * Personality Changes * Loss of social inhibitions * Depression * Memory Loss * Loss of Executive Function * The ability to plan and use problem-solving skills inhibits normal life skills such as impulse control and appropriately paying attention in general * Seizures * Severe decline in thinking and reasoning abilities (dementia ). * Motor Skills become affected, many may have difficulty walking * Patterns of movement abnormalities can occur as well such as: * Parkinsonism : * Generally will see bradykinesia , tremors, and muscle rigidity. While these vary among individuals as mentioned, over time, almost all patients with this condition will be unable to walk, speak and care for themselves.
Leukoencephalopathy with neuroaxonal spheroids
Leukoencephalopathy with vanishing white matter
Megalencephalic leukoencephalopathy with subcortical cysts
Neurodegeneration with brain iron accumulation
Camel spongiform encephalopathy
Neurofibrillary tangle
Limbic-predominant age-related TDP-43 encephalopathy
Variably protease-sensitive prionopathy