The<unk>  involves many related topics including: * the choice of an estimand (measure of effect size) of interest that is closely linked to the objectives of the trial, * the choice and definition of analysis sets, * the choice of an appropriate statistical model for the type of data being studied, * appropriate accounting for the treatment assignment process, * handling of missing data, * handling of multiple comparisons or endpoints, * accounting for interim analyses and trial adaptations, * and appropriate data presentation. One basic guidance document on this topic is the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use guidance E9.
Analysis of clinical trials
In silico clinical trials
Platform trial
Significant event audit
Diagnosis-related group
Cost-effectiveness analysis
Solidarity trial
Clinical peer review