These adverse effects for<unk>  have been reported as events in clinical trials: Central nervous system Rare reports have been made of<unk>  causing malaise, dizziness, somnolence, insomnia, and vertigo. In severely ill, elderly patients, cases of reversible mental confusion, agitation, depression, and hallucinations have been reported.<unk>  causes fewer central nervous system adverse reactions and drug interactions compared with cimetidine. Cardiovascular Arrhythmias such as tachycardia, bradycardia, atrioventricular block, and premature ventricular beats have also been reported. Gastrointestinal All drugs in the H2 receptor blocker class of medicines have the potential to cause vitamin B12 deficiency, secondary to a reduction in food-bound vitamin B12 absorption. Elderly patients taking H2 receptor antagonists are more likely to require B12 supplementation than those not taking such drugs. H2 blockers may also reduce the absorption of drugs (azole antifungals, calcium carbonate) that require an acidic stomach. In addition, multiple studies suggest the use of H2 receptor antagonists such as<unk>  may increase the risk of infectious diarrhoea, including traveller's diarrhoea and salmonellosis. A 2005 study found that by suppressing acid-mediated breakdown of proteins,<unk>  may lead to an elevated risk of developing food or drug allergies, due to undigested proteins then passing into the GI tract, where sensitisation occurs. Patients who take these agents develop higher levels of immunoglobulin E against food, whether they had prior antibodies or not. Even months after discontinuation, an elevated level of IgE in 6% of patients was still found in the study. Liver Cholestatic hepatitis, liver failure, hepatitis, and jaundice have been noted, and require immediate discontinuation of the drug. Blood tests can reveal an increase in liver enzymes or eosinophilia, although in rare instances, severe cases of hepatotoxicity may require a liver biopsy. Lungs<unk>  and other histamine H2 receptor antagonists may increase the risk of pneumonia in hospitalised patients. They may also increase the risk of community-acquired pneumonia in adults and children. Blood Thrombocytopenia is a rare but known side effect. Drug-induced thrombocytopenia usually takes weeks or months to appear, but may appear within 12 hours of drug intake in a sensitised individual. Typically, the platelet count falls to 80% of normal, and thrombocytopenia may be associated with neutropenia and anemia. Skin Rash, including rare cases of erythema multiforme, and rare cases of hair loss and vasculitis have been seen.
Ranitidine
Azacitidine
Cimetidine
Lansoprazole
Dexlansoprazole
Pantoprazole
Sucralfate
Rabeprazole