<unk>  is a very rare autosomal dominant leukodystrophy, which are neurological conditions caused by anomalies in the myelin which protects nerve fibers in the brain. The most common type is the infantile form that usually begins during the first 2 years of life. Symptoms include mental and physical developmental delays, followed by the loss of developmental milestones, an abnormal increase in head size and seizures. The juvenile form of<unk>  has an onset between the ages of 2 and 13 years. These children may have excessive vomiting, difficulty swallowing and speaking, poor coordination, and loss of motor control. Adult-onset forms of<unk>  are less common. The symptoms sometimes mimic those of Parkinson’s<unk>  or multiple sclerosis, or may present primarily as a psychiatric disorder. According to the National Institute of Neurological Disorders and Stroke, the destruction of white matter is accompanied by the formation of Rosenthal fibers—abnormal clumps of protein that accumulate in astrocytes in the brain. The<unk>  occurs in both males and females, and no ethnic, racial, geographic or cultural/economic differences are seen in its distribution.<unk>  is a progressive and often fatal<unk> .
Alexander disease
Leber's hereditary optic neuropathy
Kjer's optic neuropathy
Corneal-cerebellar syndrome
Graves' ophthalmopathy
Neuromyelitis optica spectrum disorder
Ocular myasthenia
Bosch-Boonstra-Schaaf optic atrophy syndrome