Mutations in the NR0B1 gene located on the<unk>  chromosome <unk> p21.3-p21.2) cause<unk> . The NR0B1 gene provides instructions to make a transcription factor protein called DAX1 that helps control the activity of certain genes. When the NR0B1 gene is deleted or mutated, the activity of certain genes is not properly controlled. This leads to problems with the development of the adrenal glands, two structures in the brain (the hypothalamus and pituitary gland), and reproductive tissues (the ovaries or testes). These tissues are important for the production of many hormones that control various functions in the body. When these hormones are not present in the correct amounts, the signs and symptoms of adrenal insufficiency and hypogonadotropic hypogonadism can result. This condition is inherited in an<unk><unk>  recessive pattern.
X-linked adrenal hypoplasia congenita
Lipoid congenital adrenal hyperplasia
Kallmann syndrome
Congenital adrenal hyperplasia
Thyroid dysgenesis
XYYYY syndrome
Hanhart syndrome
Klinefelter syndrome