The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta-2 microglobulin (beta2M). It is thought that this protein functions to regulate circulating iron uptake by regulating the interaction of the transferrin receptor with transferrin. The<unk> gene contains 7 exons spanning 12 kb. The full-length transcript represents 6 exons.<unk> protein is composed of 343 amino acids. There are several components, in sequence: a signal peptide (initial part of the protein), an extracellular transferrin receptor-binding region (α1 and α2), a portion that resembles immunoglobulin molecules (α3), a transmembrane region that anchors the protein in the cell membrane, and a short cytoplasmic tail.<unk> expression is subjected to alternative splicing. The predominant<unk> full-length transcript has ~4.2 kb. Alternative<unk> splicing variants may serve as iron regulatory mechanisms in specific cells or tissues.<unk> is prominent in small intestinal absorptive cells, gastric epithelial cells, tissue macrophages, and blood monocytes and granulocytes, and the syncytiotrophoblast, an iron transport tissue in the placenta.
HFE 
NLM
CMF 
MOPP 
E-med
CAPOX
POMP
FCM 