<unk> , sold under the brand name Elavil among others, is a tricyclic antidepressant primarily used to treat major depressive disorder and a variety of pain syndromes from neuropathic pain to fibromyalgia to migraine and tension headaches. Due to the frequency and prominence of side effects,<unk>  is generally considered a second-line therapy for these indications. The most common side effects are dry mouth, drowsiness, dizziness, constipation, and weight gain. Of note is sexual dysfunction, observed primarily in males. Glaucoma, liver toxicity and abnormal heart rhythms are rare but serious side effects. Blood levels of<unk>  vary significantly from one person to another, and<unk>  interacts with many other medications potentially aggravating its side effects.<unk>  was discovered in the late 1950s by scientists at Merck and approved by the US Food and Drug Administration (FDA) in 1961. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. In 2019, it was the 94th most commonly prescribed medication in the United States, with more than 8million prescriptions.
Amitriptyline
Nortriptyline
Venlafaxine
Trazodone
Guanfacine
Nabilone
Citalopram
Atomoxetine