Most cases of<unk>  are transmitted as a mutation on the X chromosome and are thus called an "X-linked trait". The affected gene on the X chromosome codes for the gp91 protein p91-PHOX (91 is the weight of the protein in kDa; the gp means glycoprotein).<unk>  can also be transmitted in an autosomal recessive fashion (via CYBA, NCF1, NCF2 and NCF4) which affect other PHOX proteins. The type of mutation that causes both types of<unk>  are varied and may be deletions, frame-shift, nonsense, and missense. A low level of NADPH, the cofactor required for superoxide synthesis, can lead to<unk> . This has been reported in women who are homozygous for the genetic defect causing glucose-6-phosphate dehydrogenase deficiency (G6PD), which is characterised by reduced NADPH levels.
Chronic granulomatous disease
Common variable immunodeficiency
Wiskott–Aldrich syndrome
Severe combined immunodeficiency
Primary immunodeficiency
X-linked agammaglobulinemia
Selective immunoglobulin A deficiency
SAPHO syndrome