Pharmacodynamics<unk>  is a nonsteroidal anti-inflammatory drug (NSAID), acting specifically as a relatively selective cyclooxygenase-2 inhibitor. However, the pharmacological profile of<unk>  is peculiar, and additional, unknown/yet-to-be-identified mechanisms appear to also be involved. One pathway that has been implicated in its actions is the ecto-5'-nucleotidase (e-5′NT/CD73)/adenosine A2A receptor pathway. Pharmacokinetics<unk>  is absorbed rapidly following oral administration.<unk>  undergoes extensive biotransformation, mainly to 4-hydroxynimesulide (which also appears to be biologically active). Food, gender, and advanced age have negligible effects on<unk>  pharmacokinetics. Moderate chronic kidney disease does not necessitate dosage adjustment, while in patients with severe chronic kidney disease or liver disease,<unk>  is contraindicated.<unk>  has a relatively rapid onset of action, with meaningful reductions in pain and inflammation observed within 15 minutes from drug intake. The therapeutic effects of<unk>  are the result of its complex mode of action, which targets a number of key mediators of the inflammatory process such as: COX-2 mediated prostaglandins, free radicals, proteolytic enzymes, and histamine. Clinical evidence is available to support a particularly good profile in terms of gastrointestinal tolerability.
Nimesulide
Hefutoxin
Ricin
Psalmotoxin
Ioxaglic acid
Toxin
Eoxin
Kaliotoxin