Electrolyte abnormalities (e.g. hypercalcaemia and hyperphosphataemia) are common overdose symptoms. Treatment is mostly supportive, with particular attention being paid to correcting electrolyte anomalies and reducing intake of calcium in both the form of supplementation and diet. As it is so heavily bound to plasma proteins haemodialysis is unlikely to be helpful in cases of overdose. Early symptoms of overdose can include: * Weakness * Headache * Somnolence * Nausea * Vomiting * Dry mouth * Constipation * Muscle pain * Bone pain * Metallic taste in the mouth. It is worth noting, however, that may of these symptoms are also indicative of kidney failure and hence may be masked by the patient's condition. Late symptoms of overdose include: * Loss of appetite * Weight loss * Conjunctivitis (calcific) * Pancreatitis * Photophobia * Rhinorrhoea * Pruritus * Hyperthermia * Decreased libido * Elevated BUN * Hypercholesterolaemia * Elevated AST and ALT * Ectopic calcification * Hypertension * Cardiac arrhythmias * Somnolence * Death * Psychosis (rare)
Paricalcitol
Geritol
Miglitol
Mannitol
Lisuride
Tolvaptan
Pulsatile insulin
Dauricine