According to some experts,<unk>  <unk>  may be caused due to alteration in the brain triggered during early stages of Alzheimer's disease or other forms of dementia. However, exact causes of<unk>  are still unknown. Risk factors of both dementia and<unk>  are considered to be the same. They are aging, genetic (heredity) cause of Alzheimer's or other dementia, and risk of cardiovascular disease. Individuals with<unk>  have increased oxidative damage in their nuclear and mitochondrial brain DNA. A widely studied biomarker of DNA damage, 8-hydroxyguanine was found to be elevated in nuclear DNA of the frontal and temporal lobe of individuals with<unk>  and in mitochondrial DNA of the temporal lobe compared with age matched control subjects. Other oxidized DNA bases were also increased in the brains of individuals with<unk> . These findings suggested that oxidative damage to DNA occurs in the earliest detectable phase of Alzheimer's disease and thus may play a significant role in the pathogenesis of this disease.
Mild cognitive impairment
Severe cognitive impairment
Dyssomnia
Extrapyramidal symptoms
Irregular sleep–wake rhythm
Orthosomnia
Parasomnia
Hypersomnia