<unk>  often increases serum potassium levels and can cause hyperkalemia, a very serious condition. Therefore, it is recommended that people using this medication avoid potassium supplements and salt substitutes containing potassium. Physicians must be careful to monitor potassium levels in both males and females who are taking<unk>  as a diuretic, especially during the first twelve months of use and whenever the dosage is increased. Doctors may also recommend that some patients may be advised to limit dietary consumption of potassium-rich foods. However, recent data suggests that both potassium monitoring and dietary restriction of potassium intake is unnecessary in healthy young women taking<unk>  for acne.<unk>  together with trimethoprim/sulfamethoxazole increases the likelihood of hyperkalemia, especially in the elderly. The trimethoprim portion acts to prevent potassium excretion in the distal tubule of the nephron.<unk>  has been reported to induce the enzymes CYP3A4 and certain UDP-glucuronosyltransferases (UGTs), which can result in interactions with various medications. However, it has also been reported that metabolites of<unk>  irreversibly inhibit CYP3A4. In any case,<unk>  has been found to reduce the bioavailability of oral estradiol, which could be due to induction of estradiol metabolism via CYP3A4.<unk>  has also been found to inhibit UGT2B7.<unk>  can also have numerous other interactions, most commonly with other cardiac and blood pressure medications, for instance digoxin. Licorice, which has indirect mineralocorticoid activity by inhibiting mineralocorticoid metabolism, has been found to inhibit the antimineralocorticoid effects of<unk> . Moreover, the addition of licorice to<unk>  has been found to reduce the antimineralocorticoid side effects of<unk>  in women treated with it for hyperandrogenism, and licorice hence may be used to reduce these side effects in women treated with<unk>  as an antiandrogen who are bothered by them. On the opposite end of the<unk> ectrum,<unk>  is useful in reversing licorice-induced hypokalemia. Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) have been found to attenuate the diuresis and natriuresis induced by<unk> , but, not to affect its antihypertensive effect. Some research has suggested that<unk>  might be able to interfere with the effectiveness of antidepressant treatment. As the medication acts as an antimineralocorticoid, it is thought that it might be able to reduce the effectiveness of certain antidepressants by interfering with normalization of the hypothalamic–pituitary–adrenal axis and by increasing levels of glucocorticoids such as cortisol. However, other research contradicts this hypothesis and has suggested that<unk>  might actually produce antidepressant effects, for instance studies showing antidepressant-like effects of<unk>  in animals.
Spironolactone
Chlorothiazide
Cyclothiazide
Amiloride
Hydrochlorothiazide
Furosemide
Torasemide
Bumetanide