Mechanism of action This image shows the different receptors and subunits involved in the mechanism of anchorage and fusion of 320px<unk>  belongs to a kind of drugs categorized as antiretroviral, specifically it is an anchoring inhibitor that blocks HIV-1 entry into the host cell. It binds to a concrete hydrophobic fusion peptide called gp41, which is a transmembrane glycoprotein located in the retrovirus HIV-1 envelope. Target cell interacts with the gp41 peptide in order to form a pre-hairpin structure which joins HIV-1 and host cell membranes. Gp41 is exposed with the assistance of another glycoprotein (gp120) also located in the envelope of the retrovirus. The structural reason is based on the fact that two gp41 combine with other gp120 composing a trimer. Firstly, it interacts with the receptor CD4 of a T4 human cell (also called Th or helper lymphocyte). The fusion causes an increase of concentration of HIV-1 on the target cell’s surface, and that promotes a switch which increases the affinity of gp120 for chemokine receptors that are disposed onto the target cell surface. This interaction produces a conformational change in the glycoprotein gp120 that exposes gp41. This process would be active because<unk>  does not interferes in this part of it, but when gp41 is exposed, the developed drug<unk>  would commence its mechanism of action and the inhibition of the fusion would start to take place.<unk>  binding to gp41 inhibits the anchoring of the<unk> us and the membrane fusion, and that means that the genetic controlling material of the retrovirus HIV-1 can not be introduced in the T4 lymphocyte. As a result, infection would not be initiated. 450px Differences from other antiretroviral drugs<unk>  mechanism of action differs from other drugs. Enfuvirtide (also known as T-20), for example, is a fusion inhibitor which binds to a region of the glycoprotein gp41 called HR1 in order to prevent membrane fusion. While enfurtivide inhibits the formation of the hairpin which is able to trigger the membrane fusion,<unk>  directly blocks the insertion inhibiting the anchorage which is the previous stage of the hairpin formation (because to develop the hairpin it is necessary the fusion and<unk>  impedes it.
VIR-576
BGR-34
NFPA 704
GRAd-COV2
C-KAD
COVAX-19
SRD5A3-CDG
CURB-65