Though<unk><unk>  can be a complication of other<unk>  diseases, when it occurs in isolation it is typically caused by a mutation in the pyruvate dehydrogenase complex genes. It has either an autosomal recessive or X-linked mode of inheritance.<unk>  can be caused by mutations on the X chromosome or in mitochondrial DNA.
Congenital lactic acidosis
Pipecolic acidemia
Dicarboxylic aminoaciduria
Phenylketonuria
Glutaric acidemia type 2
Methylmalonic acidemia
D-Glyceric acidemia
Hawkinsinuria