Patients with perforated<unk>  usually present with a sudden onset of severe, sharp abdominal pain in the right lower quadrant (RLQ), that is similar to acute appendicitis. Most patients describe generalized pain; a few present with severe epigastric pain, located in the upper abdominal area. As even slight movement can tremendously worsen their pain, these patients assume a fetal position. These patients may also demonstrate signs and symptoms of septic shock, such as tachycardia (increased heart rate), hypotension (low blood pressure), and anuria (when no urine is produced from the kidneys). Not surprisingly, these indicators of shock may be absent in elderly, immunocompromised patients or in those with diabetes. Patients also experience nausea, vomiting, decreased appetite, and sweating.
Valentino's syndrome
Temple–Baraitser syndrome
Catel–Manzke syndrome
Seaver Cassidy syndrome
Bertolotti's syndrome
Nance–Horan syndrome
Neu–Laxova syndrome
Grinspan's syndrome