Viral<unk> 's<unk>  may be caused by a slow virus infection (i.e., paramyxoviridae) present for many years before symptoms appear. Associated viral infections include respiratory syncytial virus, canine distemper virus, and the measles virus. However, recent evidence has cast some doubt upon the measles association. Laboratory contamination may have played a role in past studies linking paramyxovirus (e.g. measles) to<unk> 's<unk> . Genetic There is a hereditary factor in the development of<unk> . Two genes, SQSTM1 and RANK, and specific regions of chromosome 5 and 6 are associated with<unk> . Genetic causes may or may not involve a family history of<unk> 's<unk> . About 40–50% of people with the inherited version of<unk> 's<unk>  have a mutation in the gene SQSTM1, which encodes a protein, called p62, that is involved in regulating the function of osteoclasts (bone cells). However, about 10-15 percent of people that develop the<unk>  without any family history also have a mutation in the SQSTM1 gene.<unk>  is associated with mutations in RANK. Receptor Activator of Nuclear Factor κ B (RANK), which is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. Additional genetic associations include: Name OMIM Locus Gene<unk> 1 6p ?<unk> 2 18q22.1 RANK<unk> 3 5q35 SQSTM1<unk> 4 5q31 ?
Paget's disease of bone
Diffuse idiopathic skeletal hyperostosis
Albright's hereditary osteodystrophy
Giant-cell tumor of bone
Fibrous dysplasia of bone
Tumoral calcinosis
Metabolic bone disease
Oncogenic osteomalacia