<unk>  are a major clinical concern that can cause severe pain,<unk>  fractures, spinal cord compression, hypercalcaemia, anemia, spinal instability, decreased mobility, and rapid degradation in the quality of life for patients. Patients have described the pain as a dull ache that grows worse over time, with intermittent periods of sharp, jagged pain. Even under controlled pain management, these periods of breakthrough pain can occur rapidly, without warning, several times a day. Pain may be worse at night and partially relieved by activity.<unk>  to weightbearing<unk> s may become symptomatic early in the course of disease as compared to<unk>  to the flat<unk> s of the rib or sternum. ; Effects of<unk>  Major complications secondary to<unk>  are termed Skeletal-Related Events (SREs). * Occurrence of pathological long<unk>  and vertebral fractures * Development of spinal cord compression * Need for radiation for pain relief or to treat or prevent pathological fractures or spinal cord compression * Requirement for surgery to<unk>  * Episodes of hypercalcaemia of malignancy Other symptoms include: *Spinal Instability *Compression of the Cauda Equina *Cranial Nerve Palsies * Suppression of<unk>  marrow function (i.e anemia) * Decreased mobility 240x240px
Bone metastasis
Bone tumor
Bone sarcoma
Osteomyelitis
Osteoma
Osteopetrosis
Bone cyst
Tumoral calcinosis