Insect studies Extensive studies in the honeybee showed that<unk>  LD50 is 7.1 µg with a 95% confidence interval of 4.57-11.2 µg/bee. In comparison, the LD50 of imidacloprid is 17,9 ng per bee. The difference in these comparable substances may be explained by a slightly weaker affinity of<unk>  for nAChr when compared with imidacloprid. Neonicotinoids with a nitroguanidine group, such as imidacloprid, are most toxic to honey bees.<unk>  has an acyclic group instead of a second heterocyclic ring and is therefore much less toxic to honey bees than nitro-substituted compounds. Humans As of now, two human case-studies have been described with acute poisoning by ingestion of an insecticide mixture containing<unk>  whilst trying to commit suicide. Both patients were transported to an emergency room within two hours, and were instantly experiencing nausea, muscle weakness, convulsions and low body temperature (33.7 °C and 34.3 °C respectively). Symptoms such as muscle weakness seem to be similar to organophosphate insecticide exposure. Hypothermia and convulsions can be directly explained by the active<unk>  compound which react with acetylcholine- and nicotinic receptors. Although mammalian toxicity is recorded as low, high doses of<unk>  are recorded to be toxic to humans.
Acetamiprid
Degmacyte
Ramelteon
Drupanol
Lorcaserin
Melitracen
Tasimelteon
Tolcapone