<unk>  is believed to reduce swelling of the blood vessels surrounding the brain. This swelling is associated with the head pain of a migraine attack.<unk>  blocks the release of substances from nerve endings that cause more pain and other symptoms like nausea, and sensitivity to light and sound. It is thought that these actions contribute to relief of symptoms by<unk> .<unk>  is a serotonin receptor agonist, specifically an agonist of certain 5-HT1 family receptors.<unk>  binds with high affinity to the 5-5-HT1B, 1D, 1F receptors. It has a modest affinity to the 5-5-HT1A, 1E, 2B, 7 receptors, and little to no affinity at the 5-5-HT2A, 2C, 3, 4, 5A, 6 receptors.<unk>  has no significant affinity or pharmacological activity at adrenergic α1, α2, or β; dopaminergic D1 or D2; muscarinic; or opioid receptors.<unk>  could be efficiently co-administrated with nitric oxide synthase (NOS's) inhibitors for the treatment of NOS-dependent diseases (US patent US 2007/0254940). Two theories have been proposed to explain the efficacy of 5-HT1 receptor agonists in migraine. One theory suggests that activation of 5-HT1 receptors located on intracranial blood vessels, including those on the arteriovenous anastomoses, leads to vasoconstriction, which is correlated with the relief of migraine headache. The other hypothesis suggests that activation of 5-HT1 receptors on sensory nerve endings in the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
Eletriptan
Sumatriptan
Rizatriptan
Frovatriptan
Almotriptan
Naratriptan
Zolmitriptan
Triptan