The most commonly reported adverse effect of taking a<unk>  by mouth for the prevention of stomach ulcers is diarrhea. In clinical trials, an average 13% of people reported diarrhea, which was dose-related and usually developed early in the course of therapy (after 13 days) and was usually self-limiting (often resolving within 8 days), but sometimes (in 2% of people) required discontinuation of<unk> . The next most commonly reported adverse effects of taking<unk>  by mouth for the prevention of gastric ulcers are: abdominal pain, nausea, flatulence, headache, dyspepsia, vomiting, and constipation, but none of these adverse effects occurred more often than when taking placebos. In practice, fever is almost universal when multiple doses are given every 4 to 6 hours. There are increased side effects with sublingual or oral<unk> , compared to a low dose (400 ug) vaginal<unk> . However, low dose vaginal<unk>  was linked with low complete abortion rate. The study concluded that sublingually administered<unk>  dosed at 600 ug or 400 ug had greater instances of fever and diarrhea due to its quicker onset of action, higher peak concentration and bioavailability in comparison to vaginal or oral<unk> . For the indication of medical abortion, bleeding and cramping is commonly experienced after administration of<unk> . Bleeding and cramping is likely to be greater than that experienced with menses, however, emergency care is advised if bleeding is excessive.<unk>  should not be taken by pregnant women with wanted pregnancies to reduce the risk of NSAID-induced gastric ulcers because it increases uterine tone and contractions in pregnancy, which may cause partial or complete abortions, and because its use in pregnancy has been associated with birth defects. All cervical ripening and induction agents can cause uterine hyperstimulation, which can negatively affect the blood supply to the fetus and increases the risk of complications such as uterine rupture. Concern has been raised that uterine hyperstimulation that occurs during a<unk> -induced labor is more difficult to treat than hyperstimulation during labors induced by other drugs. Because the complications are rare, it is difficult to determine if<unk>  causes a higher risk than do other cervical ripening agents. One estimate is that it would require around 61,000 people enrolled in randomized controlled trials to detect a difference in serious fetal complications and about 155,000 people to detect a difference in serious maternal complications.
Misoprostol
Indometacin farnesil
Chloroxylenol
Transfluthrin
Methylergometrine
Indometacin
Ritodrine
Amixetrine