By mouth In its by mouth or oral form, it is used: * to treat high blood pressure * to prevent heart attacks * to prevent migraine headaches The combination of<unk>  and the alpha-1 blocker prazosin has sedative effects. Eye drops In its eye drop form it is used to treat open-angle and, occasionally, secondary glaucoma. The mechanism of action of<unk>  is probably the reduction of the formation of aqueous humor in the ciliary body in the eye. It was the first beta blocker approved for topical use in treatment of glaucoma in the United States (1978). When used by itself, it depresses intraocular pressure (IOP) 18–34% below baseline within first few treatments. However, there are short-term escape and long-term drift effects in some people. That is, tolerance develops. It may reduce the extent of the diurnal IOP curve up to 50%. The IOP is higher during sleep. Efficacy of<unk>  in lowering IOP during the sleep period may be limited. It is a 5–10× more potent β-blocker than propranolol.<unk>  is light-sensitive; it is usually preserved with 0.01% benzalkonium chloride (BAC), but also comes BAC-free. It can also be used in combination with pilocarpine, carbonic anhydrase inhibitors or prostaglandin analogs. A Cochrane review compared the effect of<unk>  versus brimonidine in slowing the progression of open angle glaucoma in adults but found insufficient evidence to come to conclusions. On the skin In its gel form it is used on the skin to treat infantile hemangiomas.
Timolol
Latanoprost
Pilocarpine
Travoprost
Carboprost
Tropicamide
Ibotenic acid
Dorzolamide