<unk>  can be classified into three types: mild, moderate and severe. * Mild<unk>  usually results in the destruction of red blood cells (hemolytic anemia). Rarely, affected people also excrete large amounts of a compound called 5-oxoproline (also called pyroglutamic acid, or pyroglutamate) in their urine (5-oxoprolinuria). This compound builds up when<unk>  is not processed correctly in cells. * Individuals with moderate<unk>  may experience symptoms beginning shortly after birth including hemolytic anemia, 5-oxoprolinuria, and elevated acidity in the blood and tissues (metabolic acidosis). * In addition to the features present in moderate<unk> , individuals affected by the severe form of this disorder may experience neurological symptoms. These problems may include seizures; a generalized slowing down of physical reactions, movements, and speech (psychomotor retardation); intellectual disability; and a loss of coordination (ataxia). Some people with severe<unk>  also develop recurrent bacterial infections.
Glutathione synthetase deficiency
Mitochondrial complex II deficiency
N-Acetylglutamate synthase deficiency
Holocarboxylase synthetase deficiency
Mitochondrial trifunctional protein deficiency
Purine nucleoside phosphorylase deficiency
Glutaminase deficiency
Carbamoyl phosphate synthetase I deficiency