The diagnosis is clinically made on the basis of the history of typical attacks, especially in patients from the ethnic groups in which<unk>  is more highly prevalent. An acute phase response is present during attacks, with high C-reactive protein levels, an elevated white blood cell count and other markers of inflammation. In patients with a long history of attacks, monitoring the kidney function is of importance in predicting chronic kidney failure. A genetic test is also available to detect mutations in the<unk> V gene. Sequencing of exons 2, 3, 5, and 10 of this gene detects an estimated 97% of all known mutations. A specific and highly sensitive test for<unk>  is the "metaraminol provocative test (MPT)", whereby a single 10 mg infusion of metaraminol is administered to the patient. A positive diagnosis is made if the patient presents with a typical, albeit milder,<unk>  attack within 48 hours. As MPT is more specific than sensitive, it does not identify all cases of<unk> , although a positive MPT can be very useful.
Familial Mediterranean fever
Chilaiditi syndrome
Scleroderma
Hereditary angioedema
Kawasaki disease
Sjögren syndrome
Chilblain lupus erythematosus
Periodic fever syndrome