The mechanism in which hyperleukocytosis or<unk>  manifests and disrupts homeostasis is greatly associated with leukemia's but multiple other factors may cause leukocytosis. Major types of leukocytosis and their mechanisms depend on the types of leukemia that cause them. White blood cell levels either rise in distinct white blood levels or in unison with others, a patient may be suffering from neutrophilia, lymphocytosis, monocytosis, eosinophilia, basophilia or a rise in immature blast cells. Acute myeloid leukemia - 10 to 20 percent of patients newly diagnosed with this type leukemia have hyperleukocytosis. Acute lymphoblastic leukemia - 20 to 30 percent of patients newly diagnosed with this type of leukemia have hyperleukocytosis. Chronic lymphocytic leukemia - Exact percentage of people diagnosed with chronic lymphocytic leukemia is unknown but a significant number also suffer from hyperleukocytosis. Chronic myeloid leukemia - The majority of patients suffering from chronic myeloid leukemia usually suffer from hyperleukocytosis. The primary pathophysiology of<unk>  is not completely understood, but there are two possible theories. Theory 1 Increased blood viscosity due to large leukemic blast populations which are less deformable than mature leukocytes may lead to<unk> . The accumulation of less malleable blast products in the bloodstream accumulate within the microcirculation causing an accumulation of blockages leading to<unk> . Theory 2 Hypoxic events in body regions may increase the high metabolic activity of dividing blast cells and lead to an increase in cytokine production. The increasing levels of cytokines within tissues may result in endothelial damage and subsequent hemorrhage. Therefore, hypoxia, in addition to various cytokine accumulations, act in unison to further damage tissue and attract leukemic blast cells to form a triad of damage. The combination of these theories, in addition to other events, may lead to hyperleukocytosis.
Leukostasis
Vasospasm
Leukocytosis
Thrombocytopenia
Allostasis
Cytotoxicity
Cytopenia
Lipotoxicity