Dutcher and Russell bodies (H&E stain, 100×, oil)<unk> s are large lymphocytes with abundant cytoplasm and a characteristic appearance on light microscopy. They have basophilic cytoplasm and an eccentric nucleus with heterochromatin in a characteristic cartwheel or clock face arrangement. Their cytoplasm also contains a pale zone that on electron microscopy contains an extensive Golgi apparatus and centrioles ( EM picture). Abundant rough endoplasmic reticulum combined with a well-developed Golgi apparatus makes<unk> s well-suited for secreting immunoglobulins. Other organelles in a<unk>  include ribosomes, lysosomes, mitochondria, and the<unk> sma membrane. Surface antigens Terminally differentiated<unk> s express relatively few surface antigens, and do not express common pan-B<unk>  markers, such as CD19 and CD20. Instead,<unk> s are identified through flow cytometry by their additional expression of CD138, CD78, and the Interleukin-6 receptor. In humans, CD27 is a good marker for<unk> s; naïve B<unk> s are CD27−, memory B-cells are CD27+ and<unk> s are CD27++. The surface antigen CD138 (syndecan-1) is expressed at high levels. Another important surface antigen is CD319 (SLAMF7). This antigen is expressed at high levels on normal human<unk> s. It is also expressed on malignant<unk> s in multiple myeloma. Compared with CD138, which disappears rapidly ex vivo, the expression of CD319 is considerably more stable.
Plasma cell
Prolymphocyte
Monocyte
Reactive lymphocyte
Thymocyte
Podocyte
Dendritic cell
Koilocyte