A Cochrane review in 2020 found that the combination of<unk>  plus<unk>  was better than placebo for relieving acute migraine attacks in adults. When the starting headache intensity was mild, 5 in 10 (50%) of people treated with the combination were pain-free at two hours compared with about 2 in 10 (18%) with placebo. Almost 6 in 10 (58%) people with moderate or severe pain who were treated with the combination had pain reduced to mild or none at two hours, compared with 3 in 10 (27%) with placebo. The combination was also better than the same dose of either drug given alone in these people. Results were 5 in 10 (52%) people with<unk>  alone or about 4 in 10 (44%) with<unk>  alone.
Sumatriptan/naproxen sodium
Naproxen/diphenhydramine
Phenylephrine/ketorolac
Hydrocodone/aspirin
Celecoxib/tramadol
Butalbital/acetaminophen
Amlodipine/celecoxib
Ibuprofen/paracetamol