<unk>  (code name BW 306U), or 6-hydroxybupropion, is the major active metabolite of the antidepressant and smoking cessation drug bupropion. It is formed from bupropion by the liver enzyme CYP2B6 during first-pass metabolism. With oral bupropion treatment,<unk>  is present in plasma at area under the curve concentrations that are as many as 16–20 times greater than those of bupropion itself, demonstrating extensive conversion of bupropion into<unk>  in humans. As such,<unk>  is likely to play a very important role in the effects of oral bupropion, which could accurately be thought of as functioning largely as a prodrug to<unk> .
Hydroxybupropion
Entropion
Bupropion
Atomoxetine
Citalopram
Ectropion
Vortioxetine
Fluoxetine