Cannabis contains more than 400 different chemicals, of which about 60 are cannabinoids. The chemical composition of cannabis may vary between cannabis products, making it difficult to identify the specific chemical(s) responsible for the<unk> . The pathophysiology of<unk>  is complicated by the complex action of these chemicals throughout the body, both in the central nervous system and in the gastrointestinal system. Cannabis-related factors, such as the amount of THC in the cannabis, the amount of use, and the duration of use likely play a role, but are not yet well understood. Other factors, such as chronic stress, genetics, and emotional factors, may influence the risk for<unk> . Various pathogenic mechanistic theories attempting to explain symptoms have been put forward: *dose dependent buildup of cannabinoids and related effects of cannabinoid toxicity *the functionality of cannabinoid receptors in the brain and particularly in the hypothalamus (which regulates body temperature and the digestive system) *direct stimulation of cannabinoid receptors in the gut Cannabinoid buildup theory Tetrahydrocannabinol (THC) is a fat-soluble cannabinoid that can be deposited into a person's fat stores, accounting for the long elimination half-life of THC. During periods of stress or food deprivation, a person's fat stores can be mobilized (lipolysis) for energy consumption, releasing the previously stored THC back into the blood. The mechanism can be characterized as a "reintoxication effect." Another cannabinoid called cannabigerol acts as an antagonist at cannabinoid(CB1) and serotonin(5HT1A) receptors, antagonizing the anti-emetic effects of cannabidiol that occurs through its effects on serotonin.
Cannabinoid hyperemesis syndrome
Serotonin syndrome
Caffeinism
Nicotine poisoning
Alcohol flush reaction
Theobromine poisoning
Clinical endocannabinoid deficiency syndrome
Nicotine withdrawal