The main pathological cause of<unk>  is the absence or insufficient amount of the inner root sheath in the<unk>  staged hairs. This creates a gap in the linking between the inner root sheath and the hair cuticles. Both of these hair features stimulate hair growth but with this detachment in the linking,<unk><unk>  hairs are not able to grow to a long length. The abnormalities caused by the inner root sheath creates disruption in the support and anchoring of the<unk>  hairs. Patients with<unk><unk>  hair syndrome have mutations in the protein keratin K6HF, which is located in the middle of the hair shaft and inner root sheath, the companion layer. These mutations account for the phenotypical features of<unk> . In the Huxley cells of the inner root sheath of abnormal<unk>  hairs, there is the formation of vacuoles and the build-up of fluid which is not usually seen. There are also dyskeratotic modifications in the Henle cells, as well as the cuticle cells in both the inner root sheath and hair shaft. The hair shaft has been reported as thin for some cases and normally structured for other<unk>  reports. The inner root sheath of normal<unk>  hairs usually do not have keratin in the Huxley cells, Henle cells and inner root sheath. They are usually organised in an orderly manner and densely compacted. Genetics is one of the causing factors of<unk> . It has been studied that this hair condition is autosomal dominantly inherited.
Loose anagen syndrome
Ortner's syndrome
Meige's syndrome
FG syndrome
Sugarman syndrome
Omenn syndrome
Gardner's syndrome
Angelman syndrome