<unk>  overdose is usually treated with the opioid antagonist, naloxone. This reverses the effects of<unk>  and causes an immediate return of consciousness but may result in withdrawal symptoms. The<unk> alf-life of naloxone is shorter than some opioids, such that it may need to be given multiple times until the opioid<unk> as been metabolized by the body. Between 2012 and 2015,<unk>  was the leading cause of drug related deaths in the United States. Since then fentanyl<unk> as been a more common cause of drug related deaths. Depending on drug interactions and numerous other factors, death from overdose can take anywhere from several minutes to several<unk> ours. Death usually occurs due to lack of oxygen resulting from the lack of breathing caused by the opioid.<unk>  overdoses can occur because of an unexpected increase in the dose or purity or because of diminished opioid tolerance.<unk> owever, many fatalities reported as overdoses are probably caused by interactions with other depressant drugs such as alcohol or benzodiazepines. Since<unk>  can cause nausea and vomiting, a significant number of deaths attributed to<unk>  overdose are caused by aspiration of vomit by an unconscious person. Some sources quote the median lethal dose (for an average 75 kg opiate-naive individual) as being between 75 and 600 mg. Illicit<unk>  is of widely varying and unpredictable purity. This means that the user may prepare what they consider to be a moderate dose while actually taking far more than intended. Also, tolerance typically decreases after a period of abstinence. If this occurs and the user takes a dose comparable to their previous use, the user may experience drug effects that are much greater than expected, potentially resulting in an overdose. It<unk> as been speculated that an unknown portion of<unk> -related deaths are the result of an overdose or allergic reaction to quinine, which may sometimes be used as a cutting agent. File:US timeline. Drugs involved in overdose deaths.Drug overdoses killed more than 70,200 in the US in 2017, with<unk>  involved in 15,482 of those deaths. File:US timeline.<unk>  deaths.US yearly overdose deaths involving<unk> . File:US timeline. Opioid deaths.US yearly deaths from all opioid drugs. Included in this number are opioid analgesics, along with<unk>  and illicit synthetic opioids.
Heroin
Cannabis
Cannabis 
Cocaine
Cocaine 
Nicotine
Phencyclidine
Opioid