<unk>  works by selectively inhibiting the synthesis of microtubules via binding to the colchicine binding site of β-tubulin, thereby blocking polymerisation of tubulin dimers in intestinal cells of parasites. Disruption of cytoplasmic microtubules leads to blocking the uptake of glucose and other nutrients, resulting in the gradual immobilization and eventual death of the helminths. Poor absorption in the digestive tract makes<unk>  an efficient drug for treating intestinal parasitic infections with limited adverse effects. However<unk>  has an impact on mammalian cells, mostly by inhibiting polymeration of tubulin dimers, thereby disrupting essential microtubule structures such as mitotic spindle. Disassembly of the mitotic spindle then leads to apoptosis mediated via dephosphorylation of Bcl-2 which allows pro-apoptotic protein Bax to dimerize and initiate programmed cell death.
Mebendazole
Flubendazole
Albendazole
Tiabendazole
Triclabendazole
Praziquantel
Pyrantel
Artemether