It is characterized by recurrent "cold" staphylococcal infections (due to impaired recruitment of neutrophils), unusual eczema-like skin rashes, severe lung infections that result in pneumatoceles (balloon-like lesions that may be filled with air or pus or scar tissue) and very high (> 2000 IU/mL or 4800 mcg/L) concentrations of the serum antibody IgE. Inheritance can be autosomal dominant or autosomal recessive. Many patients with autosomal dominant STAT3<unk>  have characteristic facial and dental abnormalities, fail to lose their primary teeth, and have two sets of teeth simultaneously.
Hyperimmunoglobulin E syndrome
Anti-IgLON5 disease
Wiskott–Aldrich syndrome
MOG antibody disease
Hyper-IgM syndrome type 3
Hyper-IgM syndrome type 5
TNF receptor associated periodic syndrome
Hyper-IgM syndrome type 4