<unk>  is an<unk>  disease in which the immune system of the patient attacks a protein of the nervous system called glial fibrillary acidic protein <unk> . It was described in 2016 by researchers of the Mayo Clinic in the United States.<unk>  is an intermediate filament (IF) protein that is expressed by numerous cell types of the central nervous system (CNS) including astrocytes. The destruction of astrocytes can lead to the development of a glial scar. There are multiple disorders associated with improper<unk>  regulation and glial scarring is a consequence of several neurodegenerative conditions. The scar is formed by astrocytes interacting with fibrous tissue to re-establish the glial margins around the central injury core and is partially caused by up-regulation of<unk> .
Autoimmune GFAP astrocytopathy
Anti-NMDA receptor encephalitis
Pantothenate kinase-associated neurodegeneration
Anti-Hu associated encephalitis
Anti-neurofascin demyelinating diseases
Glial tumor
Anti-VGKC-complex encephalitis
Hereditary CNS demyelinating disease