<unk>  <unk>  is used by itself as a progestogen-only birth control pill, in combination with the estrogens ethinylestradiol (EE) or estetrol (E4), with or without supplemental folic acid (vitamin B9), as a combined birth control pill, and in combination with the estrogen estradiol (E2) for use in menopausal hormone therapy. A birth control pill with low-dose ethinylestradiol is also indicated for the treatment of moderate acne, premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), and dysmenorrhea (painful menstruation). For use in menopausal hormone therapy, E2/DRSP is specifically approved to treat moderate to severe vasomotor symptoms (hot flashes), vaginal atrophy, and postmenopausal osteoporosis. The<unk>  component in this formulation is included specifically to prevent estrogen-induced endometrial hyperplasia.<unk>  has also been used in combination with an estrogen as a component of hormone therapy for transgender women. Studies have found that EE/DRSP is superior to placebo in reducing premenstrual emotional and physical symptoms while also improving quality of life. E2/DRSP has been found to increase bone mineral density and to reduce the occurrence of bone fractures in postmenopausal women. In addition, E2/DRSP has a favorable influence on cholesterol and triglyceride levels and decreases blood pressure in women with high blood pressure. Due to its antimineralocorticoid activity,<unk>  opposes estrogen-induced salt and water retention and maintains or slightly reduces body weight. Available forms<unk>  is available in the following formulations, brand names, and indications: *<unk>  4 mg (Slynd) – progestogen-only birth control pill *<unk>  3 mg and estetrol 14.2 mg (Nextstellis (US)) – combined birth control pill * Ethinylestradiol 30 μg and<unk>  3 mg (Ocella, Syeda, Yasmin, Zarah, Zumandimine) – combined birth control pill * Ethinylestradiol 20 μg and<unk>  3 mg (Gianvi, Jasmiel, Loryna, Lo-Zumandimine, Nikki, Vestura, Yaz) – combined birth control pill, acne, PMS, PMDD, dysmenorrhea * Ethinylestradiol 30 μg,<unk>  3 mg, and levomefolate calcium 0.451 mg (Beyaz, Tydemy) – combined birth control pill with vitamin B9 supplementation, acne, PMS * Estetrol 15 mg and<unk>  3 mg (Nextstellis (CA)) – combined birth control pill * Estradiol 0.5 or 1 mg and<unk>  0.25 or 0.5 mg (Angeliq) – menopausal hormone therapy (menopausal syndrome, postmenopausal osteoporosis)
Drospirenone
Metergoline
Phenylephrine
Acebutolol
Prazosin
Clonidine
Orphenadrine
Cabergoline