CDC A<unk>  is a vaccine against<unk>  (also known as bilharzia, bilharziosis or snail fever), a parasitic disease caused by several species of fluke of the genus Schistosoma. No effective vaccine for the disease exists yet.<unk>  affects over 200 million people worldwide, mainly in rural agricultural and peri-urban areas of developing countries, and approximately 10% suffer severe health complications from the infection. While chemotherapeutic drugs, such as praziquantel, oxamniquine and metrifonate both no longer on the market, are currently considered safe and effective for the treatment of<unk> , reinfection occurs frequently following drug treatment, thus a vaccine is sought to provide long-term treatment. Additionally, experimental vaccination efforts have been successful in animal models of<unk> . Paramyosin has been proposed as a vaccine candidate. At present Sm-p80 (calpain) is the sole schistosome vaccine candidate that has been tested for its prophylactic and antifecundity efficacy in different vaccine formulations and approaches (e.g., DNA alone, recombinant protein and prime boost) in two very different experimental animal models (mouse and baboon) of infection and disease. Sm-p80-based vaccine have four effects: Reduction in adult worm numbers; Reduction in egg production (complete elimination of egg induced pathology both in baboons and mice); Protection against acute<unk> ; Therapeutic effect on adult worms. This vaccine is now ready for human clinical trials. Another target is Sm14.
Schistosomiasis vaccine
Trypanosomiasis vaccine
Malaria vaccine
Leishmaniasis vaccine
Hookworm vaccine
Brucellosis vaccine
Cholera vaccine
Edible vaccines