The followings are the common contraindications adopted from the British National Formulary. Antimuscarinic agents Drooping of eyelid in myasthenia gravis For all antimuscarinics, * Angle-closure glaucoma * Bladder outlet obstruction (BOO) * Myasthenia gravis * Gastro-intestinal obstruction * Toxic megacolon * Urinary retention * Paralytic ileus * Intestinal atony (paralysis of muscles) * Severe ulcerative colitis * Hypertension, especially M2 receptor antagonists Antinicotinic agents For anticholinergics, such as * Trimethoprim: * Blood dyscrasias * Suxamethonium: * Hyperkalemia * Low plasma-cholinesterase activity e.g. severe liver disease * Major trauma * Personal or family history of congenital myotonic disease * Personal or family history of malignant hyperthermia * Prolonged immobilisation * Severe burns * Skeletal muscle myopathies e.g. Duchenne muscular dystrophy
Cholinergic blocking drugs
Neuromuscular blocking agents
Antiprion drug
Neuromuscular-blocking drug
Chiral drugs
Muscle relaxant
Antimanic drugs
Antihypertensive drug