Classification There are at least three types of<unk> , which are distinguished by the severity of their signs and symptoms. Type A Type A, which has been identified mostly in people from North America, has moderately severe symptoms that begin in infancy. Characteristic features include developmental delay and a buildup of lactic acid in the blood (lactic acidosis). Increased acidity in the blood can lead to vomiting, abdominal pain, extreme tiredness (fatigue), muscle weakness, and difficulty breathing. In some cases, episodes of lactic acidosis are triggered by an illness or periods without food. Children with<unk>  type A typically survive only into early childhood. Type B<unk>  type B has life-threatening signs and symptoms that become apparent shortly after birth. This form of the condition has been reported mostly in Europe, particularly France. Affected infants have severe lactic acidosis, a build-up of ammonia in the blood (hyperammonemia), and liver failure. They experience neurological problems including weak muscle tone (hypotonia), abnormal movements, seizures, and coma. Infants with this form of the condition usually survive for less than 3 months after birth. Type C This type is characterised by its late onset and is associated with isolated mild intellectual delay.
Pyruvate carboxylase deficiency
Pyruvate kinase deficiency
Glutaminase deficiency
3-Methylcrotonyl-CoA carboxylase deficiency
Malonyl-CoA decarboxylase deficiency
Multiple carboxylase deficiency
Enolase deficiency
Hexokinase deficiency