Medically speaking, the term denotes a squamous intraepithelial lesion of the<unk> that shows dysplasia with varying degrees of atypia. The epithelial basement membrane is intact and the lesion is thus not invasive but has invasive potential. The terminology of<unk>  evolved over several decades. In 1989 the Committee on Terminology, International Society for the Study of<unk>  Disease (ISSVD) replaced older terminology such as<unk>  dystrophy, Bowen's disease, and Kraurosis<unk>  by a new classification system for Epithelial<unk>  Disease: * Nonneoplastic epithelial disorders of<unk> and mucosa: * Lichen sclerosus * Squamous hyperplasia * Other dermatoses * Mixed neoplastic and nonneoplastic disorders * Intraepithelial neoplasia * Squamous<unk>  <unk> , previously classified as<unk>  1-3: Source Mild dysplasia Moderate dysplasia Severe dysplasia / carcinoma in situ HPV-negative lesion with atypical keratinocytes in the basal cell layer WHO 2003<unk>  <unk>  1<unk>  2<unk>  3<unk>  3 WHO 2014 and ISSVD 2015 Low-grade squamous intraepithelial lesion (LSIL) High-grade squamous intraepithelial lesion (HSIL) Intraepithelial neoplasia, differentiated type * Non-squamous intraepithelial neoplasia * Extramammary Paget's disease * Tumors of melanocytes, noninvasive *Invasive disease<unk>  carcinoma) The ISSVD further revised this classification in 2004, replacing the three-grade system with a single-grade system in which only the high-grade disease is classified as<unk> .<unk>  is subdivided into: (Robbins Pathological Basis of Disease, 9th Ed) Classic vulvular intraepithelial neoplasia: associated with developing into the warty and basaloid type carcinoma. This is associated with carcinogenic genotypes of HPV and/or HPV persistence factors such as cigarette smoking or immunocompromised states. Differentiated<unk>  also known as<unk>  Simplex: is associated with<unk>  dermatoses such as lichen sclerosus. It is associated with atypia of the squamous epithelium.
Vulvar intraepithelial neoplasia
Vaginal intraepithelial neoplasia
Anal dysplasia
Vulvar cancer
Vulvar myiasis
Squamous intraepithelial lesion
Human papillomavirus infection
Cervical polyp