The exact mechanism for<unk>  is not well known, as specific molecular mechanisms which lead to the closing or absence of the<unk> are unclear. There are various pathways that may support or restrict regular<unk>  development. Research has shown that changing factors may also include paracrine and autocrine signals and changes in the basis of developing organs. Specific patterns of genetic transmission have not been identified for this condition. Normal reproductive organ production requires timely coordination of the following systems: external genitalia, internal ductal system, and gonadal structure. The abnormal development of the<unk> results in an incomplete unit (low, mid, high transverse septum), failure of epithelium degeneration (imperforate hymen), and<unk> . According to a number of medical professionals, timely coordination of interdependent systems is required for normal reproductive organ development in both males and females. The description of<unk>  mechanism can be explained in several steps of development of the uterovaginal canal per the information provide by these medical professionals. These interdependent systems are external genitalia, gonadal structures, and internal ductal system. The absence of androgens, Müllerian-inhibiting substance (MIS), and testes causes the continuous differentiation of the Müllerian ducts with reversion of the wolffian ducts in the female embryo. The Müllerian duct will then elongate to reach the urogenital sinus within 9 weeks of gestation; this forms the uterovaginal canal. By 15–26 weeks of gestation, cephalic growth of the sinovaginal bulb is completed. The<unk>  plate is also formed from the fusion of<unk>  cord with the sinovaginal bulb. The formation of the uterovaginal canal is thought to occur from the caudal to the cephalic portion, all while the urogenital sinus is used to create the epithelial lining. Development of the<unk> is completed by the fifth month of gestation. While the mesenchyme that surrounds the structures transitions into musculature of the genital tract, the fallopian tubes are formed via the cephalic remnants of the Müllerian duct. This developmental process attributes to the process of how proper<unk>  development takes place. Failure of the septum to regress between the fused Müllerian ducts results in a septate uterus. The incomplete fusion of the Müllerian ducts attributes to the formation of arcuate, bicornuate, or didelphid uteri. Females who have both Rokitansky-Mayer-Küster-Hauser syndrome and uterovaginal<unk>  are theorized to have a failing caudal development within the Müllerian ducts. Variations of transverse<unk>  septum might be described by the malfunctions at the level of the<unk>  plate. Though the Müllerian and urogenital sinuses play a huge role in the derivation of the<unk>  it is unclear how much of a role each of these play normal<unk>  development.
Vaginal atresia
Persistent cloaca
Omphalocele
Cervical agenesis
Vaginal hypoplasia
Cloacal exstrophy
Umbilical hernia
Umbilical cord prolapse