<unk>  (sometimes known by the abbreviation CPX) is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. It is most useful against tinea versicolor. It is sold under many brand names worldwide. Medical uses==<unk>  is indicated for the treatment of tinea pedis and tinea corporis due to Trichophyton rubrum, Trichophyton mentagrophytes and Epidermophyton floccosum, as well as seborrheic dermatitis. It is not to be used in the eyes or vagina, and nursing women should consult their doctors before use, since it is not known whether<unk>  passes into human milk. A burning sensation may be felt when first applying<unk>  on the skin. Nail infections=== In addition to other formulations,<unk>  is used in lacquers for topical treatment of onychomycosis (fungal infections of the nails). A meta-analysis of the six trials of nail infections available in 2009 concluded that they provided evidence that topical<unk>  had poor cure rates and that amorolfine might be substantially more effective, but more research was required. "Combining data from 2 trials of<unk> olamine versus placebo found treatments failure rates of 61% and 64% for<unk> olamine. These outcomes followed long treatment times (48 weeks) and this makes<unk> olamine a poor choice for nail infections. Better results were observed with the use of amorolfine lacquer; 6% treatment failure rates were found after 1 month of treatment but these data were collected on a very small sample of people and these high rates of success might be unreliable." Pharmacology== Pharmacodynamics In contrast to the azoles and other antimycotic drugs, the mechanism of action of<unk>  is poorly understood. However, loss of function of certain catalase and peroxidase enzymes has been implicated as the mechanism of action, as well as various other components of cellular metabolism. In a study conducted to further elucidate<unk> 's mechanism, several Saccharomyces cerevisiae mutants were screened and tested. Results from interpretation of the effects of both the drug treatment and mutation suggested that<unk>  may exert its effect by disrupting DNA repair, cell division signals and structures (mitotic spindles) as well as some elements of intracellular transport. It is currently being investigated as an alternative treatment to ketoconazole for seborrhoeic dermatitis as it suppresses growth of the yeast Malassezia furfur. Initial results show similar efficacy to ketoconazole with a relative increase in subjective symptom relief due to its inherent anti-inflammatory properties.
Ciclopirox
Ecallantide
Vilanterol
Roxadustat
Apremilast
Tisagenlecleucel
Ioxaglic acid
Miproxifene