It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of myeloid (CD11c+) dendritic cells.<unk>  has also been shown to activate the maturation of a specific subset of dendritic cells located within the epidermis, called Langerhans cells. Within the thymus<unk>  activation of both myeloid and plasmacytoid (CD123+) dendritic cells results in the production of regulatory T cells. Signaling<unk>  signals through a heterodimeric receptor complex composed of the<unk>  receptor CRLF2 and the IL-7R alpha chain. After binding STAT5 phosphorylation is induced, resulting in the expression of downstream transcription factors.
Thymic stromal lymphopoietin
Macrophage colony-stimulating factor
Leukemia inhibitory factor
Hemopoietic growth factor
Granulocyte-macrophage colony-stimulating factor
Major basic protein
Granulocyte colony-stimulating factor
Macrophage-activating factor