<unk> , also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene.<unk>  is a member of the inhibitor of apoptosis (IAP) family. The<unk>  protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. This has been shown by disruption of<unk>  induction pathways leading to increase in apoptosis and decrease in tumour growth. The<unk>  protein is expressed highly in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells. These data suggest<unk>  might provide a new target for cancer therapy that would discriminate between transformed and normal cells.<unk>  expression is also highly regulated by the cell cycle and is only expressed in the G2-M phase. It is known that<unk>  localizes to the mitotic spindle by interaction with tubulin during mitosis and may play a contributing role in regulating mitosis. The molecular mechanisms of<unk>  regulation are still not well understood, but regulation of<unk>  seems to be linked to the p53 protein. It also is a direct target gene of the Wnt pathway and is upregulated by beta-catenin.
Survivin
Tetherin
Perospirone
Adhyperforin
Diamphotoxin
Lectin
Suramin
Visine