The<unk><unk>  17D vaccine is considered safe, with over 500 million doses given and very few documented cases of vaccine associated illness (62 confirmed cases and 35 deaths as of January 2019). In no case of vaccine-related illness has there been evidence of the virus<unk> ting to a virulent phenotype. The majority of adverse reactions to the 17D vaccine result from allergic reaction to the eggs in which the vaccine is grown. Persons with known egg allergy should discuss this with their physician prior to vaccination. In addition, there is a small risk of neurologic disease and encephalitis, particularly in individuals with compromised immune systems and very young children. The 17D vaccine is contraindicated in (among others) infants between zero and six months or adults over 59 years of age, people with thymus disorders associated with abnormal immune cell function, people with primary immunodeficiencies, and anyone with a diminished immune capacity including those taking immunosuppressant drugs. There is a small risk of more<unk> e<unk><unk> -like disease associated with the vaccine. This reaction, known as<unk> -associated acute viscerotropic disease (YEL-AVD), causes a fairly<unk> e disease closely resembling<unk><unk>  caused by virulent strains of the virus. The risk factors for YEL-AVD are not known, although it has been suggested that it may be genetic. The 2'-5'-oligoadenylate synthase (OAS) component of the innate immune response has been shown to be particularly important in protection from Flavivirus infection. Another reaction to the<unk>  is known as<unk> -associated acute neurotropic disease (YEL-AND). The Canadian Medical Association published a 2001 CMAJ article entitled<unk><unk>  vaccination: be sure the patient needs it". The article begins by stating that of the seven people who developed system failure within two to five days of the vaccine in 1996–2001, six died "including 2 who were vaccinated even though they were planning to travel to countries where<unk><unk>  has<unk>  been reported." The article cites that "3 demonstrated histopatholic changes consistent with wild<unk><unk>  virus." The author recommends vaccination for only non-contraindicated travelers (see the articles list) and those travelers going where<unk><unk>  activity is reported or in the endemic zone which can be found mapped at the CDC website cited below. In addition, the 2010 online edition of the Center for Disease Control Traveler's Health<unk>  Book states that between 1970 and 2002 only "nine cases of<unk><unk>  were reported in unvaccinated travelers from the United States and Europe who traveled" to West Africa and South America, and 8 of the 9 died. However, it goes on to cite "only 1 documented case of<unk><unk>  in a vaccinated traveler. This nonfatal case occurred in a traveler from Spain who visited<unk> al West African countries in 1988".
Yellow fever vaccine
Rabies vaccine
Ebola vaccine
Malaria vaccine
Dengue vaccine
Typhus vaccine
Measles vaccine
Hantavirus vaccine