Physical symptoms of CMRD involving development and function of the gastrointestinal tract and nervous system typically manifest between infancy and adolescence. The symptoms of CmRD are similar to the physical symptoms of malnutrition, as the<unk>  arises due to the poor absorption of lipids and fat-soluble nutrients such as vitamin E. For this reason, the<unk>  is likely to be under-diagnosed by physicians . Fat-soluble nutrients are essential for growth, development, and normal bodily function. Vitamin E deficiency is especially serious, as the vitamin is necessary for proper neurological function and development. Without Vitamin E, neurons cannot operate correctly and signals from the brain are weakened. This leads to reduced muscle development and reduced muscle contraction. Symptoms that manifest in the GI tract are likely to be a consequence of both reduced absorption of fats and physiological stress imposed on enterocytes that can not shuttle fats into circulation . Additional symptoms that occur throughout the body can be attributed to the lack of sufficient lipid sources. *Chronic Malabsorptive Diarrhea- Diarrhea that results from the poor absorption of fats *Steatorrhea- Abnormal stools, often foul smelling, due to the increased presence of undigested fats *Vomiting *Vitamin E Deficiency- Low levels of Vitamin E due to the malabsorption of fats in the diet, causes poor brain, muscle, and eye development. *Cardiomyopathy- A class of<unk>  that affects heart muscle, causing shortness of breath, tiredness, and swelling of the legs * Slowed Growth *Failure to Thrive- Insufficient weight gain, or drastic levels of weight loss in children *Hypocholesterolemia- Low blood cholesterol levels *Hepatic Steatosis (Fatty Liver)- Excessive fat buildup in the liver, a result of the abnormal lipid panels of CMRD patients *Hyporeflexia- Absent or low levels of muscle reflexes *Amyotrophy- Muscle tissue “wasting,” the loss of muscle tissue
Chylomicron retention disease
Lysinuric protein intolerance
Inborn errors of carbohydrate metabolism
Acid lipase disease
Hereditary fructose intolerance
Glucose-galactose malabsorption
Glycogen storage disease type 0
Congenital chloride diarrhea