Red blood cells can be released prematurely by a number of mechanisms. Premature release of red blood cells is usually caused due to damage of the bone marrow due to underlying causes as well as in response to the stimulation of hormones in strong association with anemia. Erythropoetin, a hormone made by the kidneys, controls the production of red blood cells as well as the rate at which they are released from the bone marrow. When these levels of erythropoetin rise, they signal the release of immature red blood cells into the bloodstream and is linked to anemia. Damaged bone marrow can also lead to<unk> . The most common cause of bone marrow damage is penetration by cancer cells, either from the bone marrow itself or as a consequence of metastasis from another part of the body. Iron deficiency anemia blood film Association with anemia Normocytic anemia is the most commonly seen type of anemia. This type of anemia is usually caused by the underproduction of blood cells as well as hemolysis. Anemia can be caused by either overproduction or underproduction of red blood cells as well as the production of defective blood cells. Because there are more red blood cells needed in the body at that moment, they are released prematurely, leading to<unk> . Association with reticulocytosis There is a slight correlation between<unk>  and reticulocytosis. It is much easier to test for<unk>  in blood cells than to perform special staining for reticulocytosis. If<unk>  is found in the blood cells, the reticulocyte count is taken to detect further disease or stress. If a low count of reticulocytes is found, it usually indicates bone marrow stress. If a high reticulocyte count is found, it is usually linked to hemolysis, but a Coombs test may be performed in this case to rule out immune-mediated hemolysis.<unk>  can also be seen in blood smears when there is a normal reticulocyte count. This can be caused by infiltration of the bone marrow due to tumors as well as fibrosis, or scarring, of the marrow.
Polychromasia
Dyschromia
Monochromacy
Dyskaryosis
Spherocytosis
Pyknocytosis
Binucleated cells
Zoobiquity