In many cases, there is pain and discomfort in a joint which increases over time. While it can affect any bone, about half of cases show multiple sites of damage.<unk>  most commonly affects the ends of long bones such as the femur. Other common sites include the humerus, knees, shoulders, ankles and the jaw.
Avascular necrosis
Legg–Calvé–Perthes disease
Acral necrosis
Osteopetrosis
Dysbaric osteonecrosis
Rheumatoid arthritis
Osteoradionecrosis
Sickle cell disease