<unk> , sold under the brand name Gocovri among others, is a medication used to treat dyskinesia associated with parkinsonism and influenza caused by type A influenzavirus, though its use for the latter is no longer recommended due to widespread drug resistance. It acts as a nicotinic antagonist, dopamine agonist, and noncompetitive NMDA antagonist. The antiviral mechanism of action is antagonism of the influenzavirus A M2 proton channel, which prevents endosomal escape (i.e. the release of viral genetic material into the host cytoplasm).<unk>  was first used for the treatment of influenza A. After antiviral properties were initially reported in 1963,<unk>  received approval for prophylaxis against the influenza virus A in 1976. However,<unk> -resistant influenza viruses were first reported during the 1980 influenza A epidemic and resistance frequency continued to rise into the early 2000s. Currently,<unk>  is no longer recommended for the treatment of influenza A due to a high level of<unk>  resistance among circulating influenza A viruses. In 1973, the Food and Drug Administration (FDA) approved<unk>  for use in the treatment of Parkinson's disease. In 2017, the extended release formulation was approved for use in the treatment of levodopa-induced dyskinesia. Off-label uses include improvement of fatigue in multiple sclerosis and accelerating the rate of functional recovery and arousal following a brain injury.<unk>  has a mild side effect profile. Common neurological side effects include drowsiness, light headedness, dizziness, and confusion. Due to its effects on the central nervous system, it should not be combined with additional CNS stimulants or anticholinergic drugs.<unk>  is contraindicated in persons with end stage kidney disease, given that the drug is cleared by the kidneys. It should also be taken with caution in those with enlarged prostates or glaucoma, due to its anticholinergic effects. Live attenuated vaccines are contraindicated while taking<unk> , as it may limit the efficacy of the administered vaccine.
Amantadine
Rimantadine
Quifenadine
Alcaftadine
Umifenovir
Tecovirimat
Rupatadine
Inadine