About 1:1,000 to 1:4,000 individuals in the United States and Europe and 1:55,000 individuals in Japan experience<unk> . The most common symptom of<unk>  is frequent infections, particularly by the fungus Candida albicans. This symptom is especially frequent in individuals who also experience diabetes mellitus. The majority of<unk> -deficient individuals, however, do not display any significant tendencies towards chronic infections from most bacteria. This is likely due to the fact that the absence of<unk>  leads to increased neutrophil phagocytosis and degranulation as well as increased development of the adaptive immune system. That is, other aspects of the immune system typically compensate for the lack of<unk> , leading to relatively mild symptoms. Nonetheless,<unk> -deficient individuals have been found to experience more chronic inflammatory conditions (such as rheumatoid arthritis, pulmonary/skin inflammation, kidney/heart disease, etc.) than individuals with sufficient<unk> . Researchers hypothesize this may be a result of heightened adaptive immune system activity in individuals with<unk> . There is also some evidence that congenital<unk>  is correlated with higher rates of malignant tumors.
Myeloperoxidase deficiency
MBL deficiency
Leukocyte adhesion deficiency
Adenosine deaminase deficiency
Adenosine deaminase 2 deficiency
Leukocyte adhesion molecule deficiency
Neutrophil-specific granule deficiency
Primary immunodeficiency