Soil microorganisms transform<unk>  by epoxidation, hydrolysis, and reduction. When the compound was incubated with a mixed culture of organisms, chlordene (hexachlorocyclopentadine, its precursor) formed, which was further metabolized to chlordene epoxide. Other metabolites include 1-hydroxychlordene, 1-hydroxy-2,3-epoxychlordene, and<unk>  epoxide. Soil microorganisms hydrolyze<unk>  to give ketochlordene. Rats metabolize<unk>  to the epoxide 1-exo-1-hydroxyheptachlor epoxide and 1,2-dihydrooxydihydrochlordene. When<unk>  epoxide was incubated with microsomal preparations form liver of pigs and from houseflies, the products found were diol and 1-hydroxy-2,3-epoxychlordene. The metabolic scheme in rats shows two pathways with the same metabolite. The first involves following scheme:<unk>  →<unk>  epoxide → dehydrogenated derivative of 1-exo-hydroxy-2,3-exo-epoxychlordene → 1,2-dihydrooxydihydrochlordene. The second involves:<unk>  → 1-exo-hydroxychlordene → 1-exo-hydroxy, 2,3-exo-epoxychlordene → 1,2-dihydrooxydihydrochlordene.
Heptachlor
Vinyl chloride
Triphenylchloroethylene
Methanol
Beta-Hexachlorocyclohexane
Alpha-Hexachlorocyclohexane
Triphenylbromoethylene
Coal tar