Malignant cells often evolve due to a combination of reasons rather than one definitive reason. Reasons which can explain their development include genetics and family history, triggers such as infectious diseases, and exposure to risk factors. Triggers Infectious diseases play a role in the development of<unk> , with agents of infectious disease being able to produce a multitude of malignant cells. These include bacterial causes, fungal and parasitic causes and, viral causes. Bacteria, fungi and similar pathogens have the ability to form an environment within states of chronic inflammation which gives rise to oncogenic potential. Viral agents are able to assist the formation of malignant tumours due to a mechanism of cell transformation. This cell transformation can occur through either "DNA integration or cellular-DNA alteration of growth regulator genes". Inflammation can also play a role in triggering<unk>  as it can promote stages of tumour formation. The main purpose of inflammation is to repair tissue, defend the body against pathogens and regenerate cells. At the same time, inflammatory cells can also interact with malignant cells to form an inflammatory tumour microenvironment. This environment increases the likelihood of forming malignant cells through blockage of anti-tumour immunity. Once this occurs, the inflammatory tumour microenvironment begins to send out tumour-promoting signals to epithelial cells, triggering the formation of malignant cells. Risk factors Traditional risk factors of developing<unk>  include smoking, sun exposure and, having a history of cancer in the family. Other risk factors include developing post-transplant<unk>  which occurs subsequent to solid organ transplantations. Post-transplant<unk>  Individuals who undergo organ transplant surgery have an increased risk of developing<unk>  in comparison to the general population. The most common form of<unk>  being "nonmelanoma skin cancer and, posttransplant lymphoproliferative disorders". The different types of<unk>  developed post-transplant depend on which organ was transplanted. This is linked to recipients being at a higher risk when exposed to traditional risk factors as well as, the type and intensity of the operation, the duration of their immunosuppression post-operation and, the risk of developing oncogenic viral infections.
Malignancy
Degenerative disease
Mineral deficiency
Bone disease
Endocrine bone disease
Osteolysis
Neurodegenerative disease
Bone tumor