The Notch-signaling pathway is involved in multiple processes during<unk>  development, along with Wnt signaling. Cardiomyocyte differentiation, patterning of the different cardiac regions, valve development, ventricular trabeculation, and outflow tract development have all been shown to depend on the activity of specific Notch-signaling elements. The importance of Notch signaling in human disease is evident from the discovery that many mutations in components of this pathway are inherited in several genetic and acquired disorders, though one cannot acquire<unk> . Some of the mutations are thought to be on chromosome 2. Other deletions are thought to be chromosomal arms 9q34 and 20p12, which contain NOTCH1 and JAG1 and deletion of band q22 or q24. Wnt signaling also plays a role along with Notch 1,2 and JAG in the formation of cardiac tissues and<unk>  development. When there are mutations in the Notch and Wnt pathways, Notch and Wnt are either not signaled or inhibited. These pathways have to signal proteins and other pathways, like Tbx2, 3 and 20, Bmp2, 10, and Hey1 and 2 which play a major role in different parts of the<unk>  developing. When these proteins and other pathways are not signaled or are inhibited abnormalities form.
Hypoplastic right heart syndrome
Hypoplastic left heart syndrome
Asphyxiating thoracic dysplasia
Pulmonary atresia
Pulmonary hypoplasia
Congenital diaphragmatic hernia
Absent pulmonary valve syndrome
Double aortic arch