<unk>  is an immunoglobulin that binds to phospholipids and proteins associated with the cell membrane. Its name is a partial misnomer, as it is actually a prothrombotic antibody in vivo.<unk>  in living systems causes an increase in clotting time. The name derives from their properties in vitro, as these antibodies increase coagulation times in<unk> boratory tests such as the activated partial thromboplastin time (aPTT). Investigators speculate that the antibodies interfere with phospholipids used to induce in vitro coagulation. In vivo, the antibodies are thought to interact with platelet membrane phospholipids, increasing adhesion and aggregation of platelets, which accounts for the in vivo prothrombotic characteristics. The condition was first described by hematologist C. Lockard Conley in 1952.
Lupus anticoagulant
Β-Thromboglobulin
Von Willebrand factor
Thrombin–antithrombin complex
Thrombin
Fibrin degradation product
Fibrinogen
Factor VIII 