<unk> <unk>  sequestrants are the main agents used to treat<unk> . Cholestyramine and colestipol, both in powder form, have been used for many years. Unfortunately, many patients find them difficult to tolerate; although the diarrhea may improve, other symptoms such as abdominal pain and bloating may worsen. Colesevelam is a tablet and some patients tolerate this more easily. A proof of concept study of the farnesoid X receptor agonist obeticholic<unk>  has shown clinical and biochemical benefit. As of March 15, 2016, Novartis Pharmaceuticals is conducting a phase II clinical study involving a farnesoid X receptor agonist named LJN452.
Bile acid malabsorption
Irritable bowel syndrome
Fructose malabsorption
Microscopic colitis
Glucose-galactose malabsorption
Exocrine pancreatic insufficiency
Sucrose intolerance
Lactose intolerance