Oscillations of<unk>  mRNA levels. Runt-related transcription factor 2<unk>  also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that in humans is encoded by the<unk>  gene.<unk>  is a key transcription factor associated with osteoblast differentiation. It has also been suggested that<unk>  plays a cell proliferation regulatory role in cell cycle entry and exit in osteoblasts, as well as endothelial cells.<unk>  suppresses pre-osteoblast proliferation by affecting cell cycle progression in the G1 phase. In osteoblasts, the levels of<unk>  is highest in G1 phase and is lowest in S, G2, and M. The comprehensive cell cycle regulatory mechanisms that<unk>  may play are still unknown, although it is generally accepted that the varying activity and levels of<unk>  throughout the cell cycle contribute to cell cycle entry and exit, as well as cell cycle progression. These functions are especially important when discussing bone cancer, particularly osteosarcoma development, that can be attributed to aberrant cell proliferation control.
RUNX2
SOX2
BMPR1A
CDK13
SPATA16
KRAS
WRAP53
Kras