<unk>  <unk>  is a<unk>  cell dyscrasia, i.e. a disease involving the malignant degeneration of a subtype of white blood cells called<unk>  cells. It is the terminal stage and most aggressive form of these dyscrasias, constituting 2% to 4% of all cases of<unk>  cell malignancies.<unk>  may present as primary<unk> , i.e. in patients without prior history of a<unk>  cell dyscrasia or as secondary<unk>  cell dyscrasia, i.e. in patients previously diagnosed with a history of its predecessor dyscrasia, multiple myeloma. The two forms of<unk>  appear to be at least partially distinct from each other. In all cases, however,<unk>  is an extremely serious, life-threatening, and therapeutically challenging disease.
Plasma cell leukemia
Waldenström macroglobulinemia
Multiple myeloma
Diffuse large B-cell lymphoma
Macroglobulinemia
Plasmablastic lymphoma
Monoclonal gammopathy of undetermined significance
Primary myelofibrosis