<unk>  <unk> , also known as hemicholine, is a drug which blocks the reuptake of choline by the high-affinity choline transporter (ChT; encoded in humans by the gene SLC5A7) at the presynapse. The reuptake of choline is the rate-limiting step in the synthesis of acetylcholine; hence,<unk>  decreases the synthesis of acetylcholine. It is therefore classified as an indirect acetylcholine antagonist. Acetylcholine is synthesized from choline and a donated acetyl group from acetyl-CoA, by the action of choline acetyltransferase (ChAT). Thus, decreasing the amount of choline available to a neuron will decrease the amount of acetylcholine produced. Neurons affected by<unk>  must rely on the transport of choline from the soma (cell body), rather than relying on reuptake of choline from the synaptic cleft.
Hemicholinium-3
Methitural
Gantacurium chloride
Mivacurium chloride
Dianethole
Phenylsilatrane
Malaoxon
Selenium disulfide