Vagus nerve Successful management of seizures plays a key role in improving quality of life. Antiepileptic medications are the main therapies for seizures; however, it appears that seizures in this syndrome do not respond well to drugs. In the cases reported in literature, numerous new and old antiepileptic drugs have been tried, but no one drug appears to be more efficacious than others. Therefore, no recommendations can be made regarding the selection of the most appropriate antiepileptic drug. As not all cases of<unk>  are the same, different individuals may respond to treatment in different ways.Alternates to antiepileptic drug treatment include the ketogenic diet and vagus nerve stimulation but not epilepsy surgery. Ketogenic Diet The ketogenic diet is a high fat, low carbohydrate diet reserved for intractable childhood epilepsies. There are no published reports on the use of the ketogenic diet in patients with<unk> . However, its efficacy and safety are well established in other difficult to control epilepsy syndromes. Epilepsy Surgery Epilepsy surgery investigations are performed to identify a discrete seizure focus. Extensive investigations in<unk>  patients fails to identify a discrete seizure focus and published data supports that that epilepsy in<unk>  is not amenable to resective surgery. VNS Therapy The vagal nerve stimulator is a battery-powered device similar to a pacemaker that is implanted under the skin. It delivers a mild electrical stimulation to the brain via the vagus nerve and has proven to be effective for the treatment of complex partial seizures. There are only a few published reports on the success of this therapy in ring chromosome<unk>  epilepsy syndrome, making it unclear if this is the optimal therapy.
Ring chromosome 20 syndrome
Ring chromosome 14 syndrome
Joubert syndrome
Chromosome 5q deletion syndrome
13q deletion syndrome
Kaufman oculocerebrofacial syndrome
Bardet–Biedl syndrome
2q37 deletion syndrome