<unk>  (also known as<unk>  disease/IPD) is a severe, constant, relentless and debilitating<unk>  that is not curable by any known means and which causes a house-bound or bed-bound state and early death if not adequately treated, usually with opioids and/or interventional procedures. It is not relieved by ordinary medical, surgical, nursing, or pharmaceutical measures. Unlike the more common chronic<unk> , it causes adverse biologic effects on the body's cardiovascular, hormone, and neurologic systems. Patients experience changes in testosterone, estrogen, cortisol, thyroid hormones, and/or pituitary hormones. Both men and women require testosterone, however many doctors neglect to test women for low testosterone. Untreated<unk>  can cause death.
Intractable pain
Chronic pain
Delayed onset muscle soreness
Rectal pain
Functional symptom
Amplified musculoskeletal pain syndromes
Abdominal pain
Asymptomatic