<unk>  <unk> , sold under the brand names Belara, Gynorelle, Lutéran, and Prostal among others, is a progestin and antiandrogen medication which is used in birth control pills to prevent pregnancy, as a component of menopausal hormone therapy, in the treatment of gynecological disorders, and in the treatment of androgen-dependent conditions like enlarged prostate and prostate cancer in men and acne and hirsutism in women. It is available both at a low dose in combination with an estrogen in birth control pills and, in a few countries like France and Japan, at low, moderate, and high doses alone for various indications. It is taken by mouth. Side effects of the combination of an estrogen and<unk>  include menstrual irregularities, headaches, nausea, breast tenderness, vaginal discharge, and others. At high dosages,<unk>  can cause sexual dysfunction, demasculinization, adrenal insufficiency, and changes in carbohydrate metabolism among other adverse effects. The drug is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It is also an antiandrogen, and hence is an antagonist of the androgen receptor, the biological target of androgens like testosterone and dihydrotestosterone. Due to its progestogenic activity,<unk>  has antigonadotropic effects. The medication has weak glucocorticoid activity and no other important hormonal activity.<unk>  was discovered in 1959 and was introduced for medical use in 1965. It may be considered a "first-generation" progestin. The medication was withdrawn in some countries in 1970 due to concerns about mammary toxicity observed in dogs, but this turned out not to apply to humans.<unk>  is available widely throughout the world in birth control pills, but is notably not marketed in any predominantly English-speaking countries. It is available alone in only a few countries, including France, Mexico, Japan, and South Korea.
Chlormadinone acetate
Methenmadinone acetate
Chlormethenmadinone acetate
Bolandiol dipropionate
Hydroxyprogesterone heptanoate
Ethinylestradiol sulfate
Ethinylestradiol sulfonate
Androstenediol dipropionate