<unk>  is an enlargement of the spleen. The spleen usually lies in the left upper quadrant (LUQ) of the human abdomen.<unk>  is one of the four cardinal signs of hypersplenism which include: some reduction in number of circulating blood cells affecting granulocytes, erythrocytes or platelets in any combination; a compensatory proliferative response in the bone marrow; and the potential for correction of these abnormalities by splenectomy.<unk>  is usually associated with increased workload (such as in hemolytic anemias), which suggests that it is a response to hyperfunction. It is therefore not surprising that<unk>  is associated with any disease process that involves abnormal red blood cells being destroyed in the spleen. Other common causes include congestion due to portal hypertension and infiltration by leukemias and lymphomas. Thus, the finding of an enlarged spleen, along with caput medusae, is an important sign of portal hypertension.
Splenomegaly
Hepatosplenomegaly
Lycopenemia
Lymphocytosis
Lymphocytopenia
Plasmacytosis
Neutrophilia
Reticulocytosis