<unk>  is a rare, hereditary, neurological disease that is inherited in an autosomal dominant fashion. The syndrome involves defects in the nervous, auditory, skeletal, visual, and endocrine systems and encompasses numerous symptoms, bearing striking similarity to other known syndromes of neuroectodermal nature such as: Werner syndrome, Cockayne syndrome and Refsum syndrome. The onset of<unk>  typically occurs between ten and twenty years of age, however, the earliest case was diagnosed at age seven. As the syndrome progresses, initial symptoms tend to intensify and new symptoms become apparent. Unlike related syndromes and despite the intensity of symptoms in the disease progression,<unk>  does not appear to shorten life expectancy. The disease is characterized by early-onset dementia, ataxia, muscle wasting, skin atrophy, and eye abnormalities. In addition, patients have the potential of developing a number of other related symptoms such as: cataracts, retinitis pigmentosa, myopia (nearsightedness), dental caries, peripheral neuropathy (peripheral nerve damage), deafness, and cystic bone changes. This syndrome was first discovered in the early 1950s by American neurologists P.<unk>  and Robert B.<unk>  who analyzed one family lineage inheritance pattern of this disease.
Flynn–Aird syndrome
Dennie–Marfan syndrome
McKittrick-Wheelock syndrome
Koolen–De Vries syndrome
Kearns–Sayre syndrome
Fox–Fordyce disease
McLeod syndrome
GRACILE syndrome