Micrograph showing<unk>  in a punch biopsy.<unk>  is diagnosed by a skin biopsy, demonstrating superficial and deep perivascular and interstitial mixed inflammatory cell infiltrate (including lymphocytes, plasma cells, mononucleated and multinucleated histiocytes, and eosinophils) in the dermis and subcutis, as well as necrotising vasculitis with adjacent<unk>  and necrosis of adnexal structures. Areas of<unk>  are often more extensive and less well defined than in granuloma annulare. Presence of lipid in necrobiotic areas may be demonstrated by Sudan stains. Cholesterol clefts, fibrin, and mucin may also be present in areas of<unk> . Depending on the severity of the<unk> , certain cell types may be more predominant. When a lesion is in its early stages, neutrophils may be present, whereas in later stages of development lymphocytes and histiocytes may be more predominant.
Necrobiosis lipoidica
Cutaneous lupus mucinosis
Acne necrotica
Tuberculosis verrucosa cutis
Granuloma annulare
Vesiculobullous disease
Ichthyosis bullosa of Siemens
Cutaneous amoebiasis