<unk>  is a veterinary drug whose prime purpose is to reverse the effects of the sedative dexmedetomidine (as well as its racemic mixture, medetomidine). It can also be used to reverse the related sedative xylazine. While it reverses both the sedative and analgesic (pain-relieving) effects of dexmedetomidine,<unk>  may not entirely reverse the cardiovascular depression that dexmedetomidine causes.<unk>  is licensed in the United States for intramuscular injection (IM) in dogs; it is, however, used off-label in cats, rabbits, and farm animals such as horses and cows, as well as in zoo medicine for reptiles (including tortoises, turtles, and alligators), armadillos, hippopotamuses, giraffes, okapi, and others. It has been given intravenously (IV), subcutaneously, intraperitoneally and, in red-eared sliders, intranasally. IV administration is recommended in emergencies.<unk>  has also been used as an antidote for various toxicities in dogs. For example, the anti-tick medication amitraz is commonly ingested by dogs who eat their anti-tick collars. Amitraz works by the same mechanism as dexmedetomidine and is thus easily reversed by<unk> .<unk>  also reverses the hypotension caused by tizanidine (a muscle relaxant) toxicity, and relieves toxicity from decongestants such as ephedrine and pseudoephedrine. Available forms<unk>  is sold at 5 mg/mL for ease of use: 5 times as much<unk>  as medetomidine is needed for full reversal, and because medetomidine is sold as 1 mg/mL, 1 mL of<unk>  reverses 1 mL of medetomidine. When the enantiomerically pure version of medetomidine (dexmedetomidine) was released, it was sold at 0.5 mg/mL, because it was twice as strong as medetomidine. As such, 1 mL of<unk>  also reverses 1 mL of dexmedetomidine. Specific populations<unk>  is not recommended for animals that are pregnant, lactating, or slated for breeding.
Atipamezole
Fabomotizole
Letrozole
Bisoctrizole
Dienogest
Protollin
Lapisteride
Ingenol mebutate