The human<unk> <unk>  coded by the<unk> 1 gene, consists of 305 amino acids and possesses 3 functional domains: the N-terminal domain, the C- terminal domain, and the conserved homeodomain motif. The homeodomain region facilitates DNA binding. The human<unk>  1 gene is located on chromosome 12, and the mRNA contains a 915 bp open reading frame (ORF) with 4 exons and 3 introns. The N-terminal region of human<unk>  is rich in serine, threonine and proline residues, and the C-terminus contains a tryptophan-rich domain. The homeodomain in<unk>  ranges from residues 95 to 155. There are also additional<unk>  genes<unk> 2,<unk>  p8) which potentially affect ESCs' differentiation. Scientists have shown that<unk> 1 is fundamental for self-renewal and pluripotency, and<unk>  p8 is highly expressed in cancer cells.
Homeobox protein NANOG
SOX gene family
Winged-helix transcription factors
Sp1 transcription factor
Mir-590 microRNA precursor family
Testis-determining factor
Mir-3180 microRNA precursor family
Mir-618 microRNA precursor family