The acutely toxic dose of aspirin is generally considered greater than 150 mg per kg of body mass. Moderate toxicity occurs at doses up to 300 mg/kg, severe toxicity occurs between 300 and 500 mg/kg, and a potentially lethal dose is greater than 500 mg/kg. Chronic toxicity may occur following doses of 100 mg/kg per day for two or more days. Monitoring of biochemical parameters such as electrolytes and solutes, liver and kidney function, urinalysis, and complete blood count is undertaken along with frequent checking of<unk>  and blood sugar levels. Arterial blood gas assessments typically find respiratory alkalosis early in the course of the overdose due to hyperstimulation of the respiratory center, and may be the only finding in a mild overdose. An anion-gap metabolic acidosis occurs later in the course of the overdose, especially if it is a moderate to severe overdose, due to the increase in protons (acidic contents) in the blood. The diagnosis of poisoning usually involves measurement of plasma<unk> , the active metabolite of aspirin, by automated spectrophotometric methods. Plasma<unk>  levels generally range from 30–100 mg/l (3–10 mg/dl) after usual therapeutic doses, 50–300 mg/l in patients taking high doses, and 700–1400 mg/l following acute overdose. Patients may undergo repeated testing until their peak plasma<unk>  level can be estimated. Optimally, plasma levels should be assessed four hours after ingestion and then every two hours after that to allow calculation of the maximum level, which can then be used as a guide to the degree of toxicity expected. Patients may also be treated according to their individual symptoms.
Salicylate poisoning
Sepsis
Tin poisoning
Myocardial infarction
Thallium poisoning
Psychomotor agitation
Sulfuric acid poisoning
Diabetic ketoacidosis