Findings indicate that β2 stimulants, especially in parenteral administration such as inhalation or injection, can induce adverse effects: * Tachycardia secondary to peripheral vasodilation and cardiac stimulation (Such tachycardia may be accompanied by palpitations.) * Tremor, excessive sweating, anxiety, insomnia, and agitation *More severe effects include paradoxical bronchospasm, hypokalemia, and in rare cases a myocardial infarction. (More severe effects, such as pulmonary edema, myocardial ischemia, and cardiac arrhythmia, are exceptional.) Asthma aggravation has been observed in patients using large doses of β2 agonists, but if it results from spontaneous course of the disease or adverse effect of the drugs is not known. The excipients, in particular sulfite, could contribute to the adverse effects. The possible loss of the bronchodilator activity of β2 mimetics could be attenuated by inhaled corticosteroid intake.
Beta2-adrenergic agonist
Beta-adrenergic agonist
Alpha-adrenergic agonist
Muscarinic antagonist
Norepinephrine–dopamine disinhibitor
Dopamine agonist
Adrenergic release inhibitor
Adenosine receptor antagonist