In 1980, the American College of Rheumatology agreed on diagnostic criteria for<unk> . Diagnosis is by clinical suspicion, presence of autoantibodies (specifically anticentromere and anti-scl70/antitopoisomerase antibodies), and occasionally by biopsy. Of the antibodies, 90% have a detectable antinuclear antibody. Anticentromere antibody is more common in the limited form (80–90%) than in the diffuse form (10%), and anti-scl70 is more common in the diffuse form (30–40%) and in African-American patients (who are more susceptible to the<unk>  form). Other conditions may mimic<unk>  sclerosis by causing hardening of the skin. Diagnostic hints that another disorder is responsible include the absence of Raynaud's phenomenon, a lack of abnormalities in the skin on the hands, a lack of internal organ involvement, and a normal antinuclear antibodies test result.
Systemic scleroderma
Scleroderma
Chilblain lupus erythematosus
Discoid lupus erythematosus
Tumid lupus erythematosus
Mixed connective tissue disease
Lupus erythematosus
Sjögren syndrome