A<unk>  <unk>  (also known as tumour-associated<unk> ; carcinogenic-<unk><unk> ; activated<unk>  is a cell type within the tumor microenvironment that promotes tumorigenic features by initiating the remodelling of the extracellular matrix or by secreting cytokines.<unk> s are a complex and abundant cell type within the tumour microenvironment; the number cannot decrease, as they are unable to undergo apoptosis.<unk> s have been found to be abundant in a tumour stroma. Myofibroblasts and<unk> s make up<unk> s. The functions of these<unk> s have been known to stimulate angiogenesis, supporting the formation of tumours and thus proliferation of<unk>  cell and metastasis.<unk>  cells are usually also drug resistant, which is contributed by<unk> s. As such, this interaction is being studied for potential anti-cancer therapy. Normal<unk> s aid in the production of components of the extracellular matrix such as collagens, fibres, glycosaminoglycans and glycoproteins and are therefore vital in tissue repair in wound healing.<unk> s however, are derived from either normal<unk> s, pericytes, smooth muscle cells, fibrocytes or mesenchymal stem cells These<unk> s then go on to support tumour growth by secreting growth factors such as Vascular Endothelial Growth Factor (VEGF), Platelet Derived Growth Factor (PDGF) and<unk>  Growth Factor (FGF) and other chemokines to stimulate angiogenesis and thus the growth of a tumour.
Cancer-associated fibroblast
Cancer stem cell
Progenitor cell
Nonspecific immune cell
Sentinel cell
Nevus cell
Tumor-infiltrating lymphocytes
Keratinocyte