<unk>  has the following binding profile: Biologic Protein Binding affinity (KinM) Binding affinity of Mesoridazine (Ki nM) Binding affinity of Sulforidazine (Ki nM) Notes SERT 1259 ND ND NET 842 ND ND DAT 1684 ND ND 5-HT1A 144.35 500 (HB) ND 5-HT1B 109 ND ND 5-HT1D 579 ND ND 5-HT1E 194 ND ND 5-HT2A 27.67 4.76 (HB) ND The ratio of 5-HT2A to D2 receptor binding is believed to dictate whether or not most antipsychotics are atypical or typical. In<unk> 's case its ratio of 5-HT2A to D2 receptor binding is below the level that's believed to be required for atypicality despite its relatively low extrapyramidal side effect liability in practice. 5-HT2C 53 157 ND Believed to play a role in the weight gain-promoting effects of antipsychotics. 5-HT3 >10000 ND ND 5-HT5A 364 ND ND 5-HT6 57.05 380 ND 5-HT7 99 73 (RC) ND α1A 3.15 2 (HB) ND Likely the receptor responsible for the orthostatic hypotension known to occur in individuals on<unk> . α1B 2.4 ND ND α2A 134.15 1612.9 (HB) ND α2B 341.65 ND ND α2C 74.9 ND ND β1 >10000 ND ND β2 >10000 ND ND M1 12.8 10 ND This receptor is believed to be the chief receptor responsible for the anticholinergic side effects of<unk>  (e.g. dry mouth, constipation, blurred vision, etc.). Likely plays a role in<unk> 's low extrapyramidal side effect liability as anticholinergic drugs such as benzatropine are routinely given to treat extrapyramidal side effects resulting from antipsychotic treatment. M2 286.33 15 ND M3 29 90 ND M4 310.33 19 ND M5 12.67 60 ND D1 94.5 ND ND D2 0.4 4.3 0.25 Believed to be the receptor responsible for the therapeutic effects of antipsychotics. D3 1.5 2.6 0.7 D4 1.5 9.1 ND D5 258 ND ND hERG 191 ND ND Likely involved in<unk> 's cardiac effects. H1 16.5 1.81 (HB) ND Likely responsible for the sedating effects of<unk> . H2 136 ND ND Regulates the release of hydrochloric acid into the stomach. H4 2400 ND ND Note: The Binding affinities given are towards cloned human receptors unless otherwise specified Acronyms used HB – Human brain receptor RC – Cloned rat receptor ND – No data
Thioridazine
Domperidone
Chlortalidone
Primidone
Rimonabant
Mepiprazole
Lorpiprazole
Roluperidone