<unk>  <unk> , is a highly aggressive form of cancer that develops from mesenchymal cells that have failed to fully differentiate into myocytes of skeletal muscle. Cells of the tumor are identified as rhabdomyoblasts. There are four subtypes – embryonal<unk> , alveolar<unk> , pleomorphic<unk> , and spindle cell/sclerosing<unk> . Embryonal, and alveolar are the main groups, and these types are the most common soft tissue sarcomas of childhood and adolescence. The pleomorphic type is usually found in adults. It is generally considered to be a disease of childhood, as the vast majority of cases occur in those below the age of 18. It is commonly described as one of the small-blue-round-cell tumors of childhood due to its appearance on an H&E stain. Despite being relatively rare, it accounts for approximately 40% of all recorded soft tissue sarcomas.<unk>  can occur in any soft tissue site in the body, but is primarily found in the head, neck, orbit, genitourinary tract, genitals, and extremities. There are no clear risk factors, but the disease has been associated with some congenital abnormalities. Signs and symptoms vary according to tumor site, and prognosis is closely tied to the location of the primary tumor. Common sites of metastasis include the lungs, bone marrow, and bones. There are many classification systems for<unk>  and a variety of defined histological types. Embryonal<unk>  is the most common type and comprises about 60% of cases. Outcomes vary considerably, with 5 years survival rates between 35% and 95% depending on the type of<unk>  involved, so clear diagnosis is critical for effective treatment and management. Accurate and quick diagnosis is often difficult due to the heterogeneity of<unk>  tumors and a lack of strong genetic markers of the disease. Treatment usually involves a combination of surgery, chemotherapy, and radiation. Sixty percent to 70% of newly diagnosed patients with nonmetastatic disease can be cured using this combined approach to therapy. Despite aggressive multimodality treatment, less than 20% of patients with metastatic<unk>  are able to be cured of their disease.
Rhabdomyosarcoma
Myosarcoma
Pyomyoma
Rhabdomyoma
Hemangiosarcoma
Liposarcoma
Angiosarcoma
Fibrosarcoma