<unk>  is a vinca alkaloid and a chemical analogue of vincristine. It binds tubulin, thereby inhibiting the assembly of microtubules.<unk>  treatment causes M phase specific cell cycle arrest by disrupting microtubule assembly and proper formation of the mitotic spindle and the kinetochore, each of which are necessary for the separation of chromosomes during anaphase of mitosis. Toxicities include bone marrow suppression (which is dose-limiting), gastrointestinal toxicity, potent vesicant (blister-forming) activity, and extravasation injury (forms deep ulcers).<unk>  paracrystals may be composed of tightly packed unpolymerized tubulin or microtubules.<unk>  is reported to be an effective component of certain chemotherapy regimens, particularly when used with bleomycin, and methotrexate in<unk> M chemotherapy for Stage IA or IIA Hodgkin lymphomas. The inclusion of<unk>  allows for lower doses of bleomycin and reduced overall toxicity with larger resting periods between chemotherapy cycles.
Vinblastine
Epirubicin
Valrubicin
Doxorubicin
Daunorubicin
Bleomycin
Vincristine
Normustine