Some studies have suggested that<unk>  is related to bipolar disorder, hypomania, and schizophrenia. Although creative ability was observed in the patients of these studies, signs of creativity were observed, not<unk>  specifically. Therefore, it is difficult to say with absolute certainty that<unk>  is a symptom of these psychiatric illnesses because creativity in patients with bipolar disorder, hypomania, or schizophrenia may manifest into something aside from writing. However, other studies have shown significant accounts between<unk>  and temporal lobe epilepsy and chemical causes. Temporal lobe epilepsy Image of the temporal lobe<unk>  is a symptom of temporal lobe epilepsy, a condition of reoccurring seizures caused by excessive neuronal activity, but it is not a common symptom among patients. Less than 10 percent of patients with temporal lobe epilepsy exhibit characteristics of<unk> . Temporal lobe epilepsy patients may exhibit irritability, discomfort, or an increasing feeling of dread if their writing activity is disrupted. To elicit such responses when interrupting their writing suggests that<unk>  is a compulsive condition, resulting in an obsessive motivation to write. A temporal lobe epilepsy may influence frontotemporal connections in such a way that the drive to write is increased in the frontal lobe, beginning with the prefrontal and premotor cortex planning out what to write, and then leading to the motor cortex (located next to the central fissure) executing the physical movement of writing. Most temporal lobe epilepsy patients who suffer from<unk>  can write words, but not all may have the capacity to write complete sentences that have meaning. Chemical Certain drugs have been known to induce<unk>  including donepezil. In one case study, a patient taking donepezil reported an elevation in mood and energy levels which led to<unk>  and other excessive forms of speech (such as singing). Six other cases of patients taking donepezil and experiencing mania have been previously reported. These patients also had cases of dementia, cognitive impairment from a cerebral aneurysm, bipolar I disorder, and/or depression. Researchers are unsure why donepezil can induce mania and<unk> . It could potentially result from an increase in acetylcholine levels, which would have an effect on the other neurotransmitters in the brain. Another potential cause of<unk>  is from one of the body's neurotransmitters, dopamine (DA). Dopamine has been known to decrease latent inhibition, which causes a decrease in the ability to habituate to different stimuli. Low latent inhibition leads to an excessive level of stimulation and could contribute to the onset of<unk>  and general creativity. This research implies that there is a direct correlation between the levels of DA between neuronal synapses and the level of creativity exhibited by the patient. DA agonists increase the levels of DA between synapses which results in higher levels of creativity, and the opposite is true for DA antagonists.
Hypergraphia
Asymmetric crying facies
Leonine facies
Spotted lunulae
Paragraphia
Macrodontia 
Macroglossia
Brachyphalangy