GLP-1 and DPP-4 inhibitors<unk> s are a group of metabolic hormones that stimulate a decrease in blood glucose levels.<unk> s are released after eating and augment the secretion of insulin released from pancreatic beta cells of the islets of Langerhans by a blood glucose-dependent mechanism. Some<unk> s (GLP-1) also inhibit glucagon release from the alpha cells of the islets of Langerhans. In addition, they slow the rate of absorption of nutrients into the blood stream by reducing gastric emptying and may directly reduce food intake. The two main candidate molecules that fulfill criteria for an<unk>  are the intestinal peptides glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP, also known as: glucose-dependent insulinotropic polypeptide). Both GLP-1 and GIP are rapidly inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4). Both GLP-1 and GIP are members of the glucagon peptide superfamily.
Incretin
Histrelin
Somatostatin
Ghrelin
Nesfatin-1
Bryostatin
Gluten exorphin
Beta-Endorphin