<unk>  is an experimental drug that is a 5-HT3 antagonist under development by Solvay Pharmaceuticals. 5-HT3 receptors are responsible for causing many things from nausea to excess bowel movements. In conditions such as irritable bowel syndrome (IBS), the receptors have become faulty or oversensitive. 5-HT3 antagonists work by blocking the nervous and chemical signals from reaching these receptors. Studies have shown that the drug can improve quality of life in men and women with diarrhea-predominant IBS.<unk>  is the first 5-HT antagonist specifically designed for IBS that is effective in men as well as women. In 2005, Solvay received response from the U.S. Food and Drug Administration that cilanserton is not approvable without additional clinical trials; further development has been discontinued.
Cilansetron
Tropisetron
Granisetron
Alosetron
Palonosetron
Avacopan
Agomelatine
Bocasan