Stimulation of specialized<unk> -sensitive nerve fibers (nociceptors) that innervate<unk>  tissue leads to the sensation of<unk> .<unk>  originates from both the periosteum and the<unk>  marrow which relay nociceptive signals to the brain creating the sensation of<unk> .<unk>  tissue is innervated by both myelinated (A beta and A delta fiber) and unmyelinated (C fiber) sensory neurons. In combination, they can provide an initial burst of<unk> , initiated by the faster myelinated fibers, followed by a slower and longer-lasting dull<unk>  initiated by unmyelinated fibers. Nociceptors responsible for<unk>  can be activated via several mechanisms including deterioration of surrounding tissue,<unk>  destruction, and physical stress which shears the<unk> , vascular, muscle, and nervous tissue.
Bone pain
Weather pains
Breast hypertrophy
Myalgia
Breast atrophy
Joint stiffness
Osteopathy
Dark skin