Mechanism of action<unk>  is an inhibitor of the enzymes PARP1 and PARP2. Pharmacokinetics The inactive main metabolite M1 is the carboxylic acid derivative of<unk> . 73% of ingested<unk>  is absorbed in the gut, and it reaches highest blood plasma concentrations after about three hours, independently of food intake. In the circulation, 83% of the substance are bound to plasma proteins. It is inactivated by carboxylesterases to the main metabolite M1, the carboxylic acid derivative, which is subsequently glucuronidated. The mean biological half-life is 36 hours. 47.5% of the substance are found in the urine and 38.8% in the feces. Unmetabolised<unk>  accounts for 11% in the urine and 19% in the feces.
Niraparib
Ledipasvir
Umifenovir
Taribavirin
Remdesivir
Bevirimat
Ribavirin
Letermovir