Macroscopy * Polypoid mass extending into broad ligament, ovaries and fallopian tubes. * Lymphatic tumor plugs as yellow, ropy or ball-like masses. Microscopy * Monotonous ovoid cells to spindly cells with minimal cytoplasm. * Prominent arterioles. Angiolymphatic invasion common. * Up to 10-15 mitotic figures per 10 HPF in most active areas. * Tongue-like infiltration between muscle bundles of myometrium. * May exhibit myxoid, epithelioid and fibrous change. * May have foam cells or hyalinization in the stroma. Immunochemistry * CD10+ * muscle markers (muscle specific actin MSA, smooth muscle actin SMA and desmin) positive in areas of smooth muscle differentiation * CD117- (c-kit -) * h-caldesmon-
Endometrial stromal sarcoma
Endometrial stromal tumour
Leiomyosarcoma
Uterine sarcoma
Uterine adenosarcoma
Uterine serous carcinoma
Uterine clear-cell carcinoma
Adenomyoma