The prognosis for individuals with severe LNS is poor. Death is usually due to kidney failure or complications from hypotonia, in the first or second decade of life. Less severe forms have better prognoses.
Lesch–Nyhan syndrome
Dystonia
Gerstmann–Sträussler–Scheinker syndrome
Autism
Catel–Manzke syndrome
Cerebral palsy
Stratton Parker syndrome
Tourette syndrome