Animation of<unk> <unk>  seen using intrinsic optical signal imaging in gyrencephalic brain. Speed 50x. From Santos E et al. Neuroimage 2014. 323x323px<unk>  <unk>  or<unk>  depolarization (SD) is a wave of electrophysiological hyperactivity followed by a wave of inhibition.<unk>  depolarization describes a phenomenon characterized by the appearance of depolarization waves of the neurons and neuroglia that propagates across the cortex at a velocity of 1.5–9.5 mm/min.<unk>  can be induced by hypoxic conditions and facilitates neuronal death in energy-compromised tissue.<unk>  has also been implicated in migraine aura, where<unk>  is assumed to ascend in well-nourished tissue and is typically benign in most of the cases, although it may increase the probability in migraine patients to develop a stroke.<unk>  depolarization within brainstem tissues regulating functions crucial for life has been implicated in sudden unexpected death in epilepsy, by way of ion channel mutations such as those seen in Dravet syndrome, a particularly severe form of childhood epilepsy that appears to carry an unusually high risk of SUDEP (sudden unexpected death in epilepsy).
Cortical spreading depression
Epileptogenesis
Subcortical ischemic depression
High-conductance state
Ischemic cascade
Zahn infarct
Neural adaptation
Cortical remapping