As with most anticonvulsants, the precise mechanism of action is unknown. Regardless,<unk>  has been shown to have anticonvulsant effects of its own.<unk>  increases GABAergic activity. At clinically relevant concentrations, it enhances central GABA neurotransmission through a barbiturate-like effect, since it increases the duration of opening of GABA-A receptor channels in hippocampal slices. It has also been shown to increase GABA levels in brain tissues by interfering with its reuptake and metabolism. Specifically, it has been shown to inhibit lactate dehydrogenase, which is an important enzyme involved in the energy metabolism of neurons. Inhibition of this enzyme can make neurons less prone to fire action potentials, likely through activation of ATP-sensitive potassium channels.<unk>  also improves the effectiveness of many other anticonvulsants, possibly due to its inhibition of certain enzymes, slowing the drugs' metabolism and increasing blood plasma levels.
Stiripentol
Mitapivat
Loteprednol
Nicorandil
Agomelatine
Vigabatrin
Bocasan
Avacopan