<unk>  often requires prolonged antibiotic therapy for weeks or months. A PICC line or central venous catheter can be placed for long-term intravenous medication administration. Some studies of children with acute<unk>  report that antibiotic by mouth may be justified due to PICC-related complications. It may require surgical debridement in severe cases, or even amputation. Antibiotics by mouth and by intravenous appear similar. Due to insufficient evidence it is unclear what the best antibiotic treatment is for<unk>  in people with sickle cell disease as of 2019. Initial first-line antibiotic choice is determined by the patient's history and regional differences in common infective organisms. A treatment lasting 42 days is practiced in a number of facilities. Local and sustained availability of drugs have proven to be more effective in achieving prophylactic and therapeutic outcomes. Open surgery is needed for chronic<unk> , whereby the involucrum is opened and the sequestrum is removed or sometimes saucerization can be done. Hyperbaric oxygen therapy has been shown to be a useful adjunct to the treatment of refractory<unk> . Before the widespread availability and use of antibiotics, blow fly larvae were sometimes deliberately introduced to the wounds to feed on the infected material, effectively scouring them clean. There is tentative evidence that bioactive glass may also be useful in long bone infections. Support from randomized controlled trials, however, was not available as of 2015. Hemicorporectomy is performed in severe cases of Terminal<unk>  in the Pelvis if further treatment won’t stop the infection.
Osteomyelitis
Cellulitis
Osteoradionecrosis
Septic arthritis
Osteitis
Rheumatoid arthritis
Osteochondropathy
Neuropathic arthropathy