Common adverse effects of<unk>  include the following: paraesthesia, fatigue, drowsiness, depression, decreased libido, bitter or metallic taste, nausea, vomiting, abdominal cramps, diarrhea, black feces, polyuria, kidney stones, metabolic acidosis and electrolyte changes (hypokalemia, hyponatremia). Whereas less common adverse effects include Stevens–Johnson syndrome, anaphylaxis and blood dyscrasias. Contraindications Contraindications include: * Hyperchloremic acidosis * Hypokalemia (low blood potassium) * Hyponatremia (low blood sodium) * Adrenal insufficiency * Impaired kidney function * Hypersensitivity to<unk>  or other sulfonamides. * Marked liver disease or impairment of liver function, including cirrhosis because of the risk of development of hepatic encephalopathy.<unk>  decreases ammonia clearance. Interactions It is possible that it might interact with: * Amphetamines, because it increases the pH of the renal tubular urine, hence reducing the clearance of amphetamines. * Other carbonic anhydrase inhibitors — potential for additive inhibitory effects on carbonic anhydrase and hence potential for toxicity. * Ciclosporin, may increase plasma levels of ciclosporin. * Antifolates such as trimethoprim, methotrexate, pemetrexed and raltitrexed. * Hypoglycemics,<unk>  can both increase or decrease blood glucose levels. * Lithium, increases excretion, hence reducing therapeutic effect. * Methenamine compounds, reduces the urinary excretion of methenamines. * Phenytoin, reduces phenytoin excretion, hence increasing the potential for toxicity. * Primidone, reduces plasma levels of primidone. Hence reducing anticonvulsant effect. * Quinidine, reduces urinary excretion of quinidine, hence increasing the potential for toxicity. * Salicylates, potential for severe toxicity. * Sodium bicarbonate, potential for kidney stone formation. * Anticoagulants, cardiac glycosides, may have their effects potentiated by<unk> .
Acetazolamide
Trabeculectomy
Osmotherapy
Mannitol
Endoscopic third ventriculostomy
Brinzolamide
Ventriculostomy
Timolol