Pharmacodynamics<unk>  is reportedly more potent as an antimineralocorticoid relative to spironolactone, but is considerably less potent and effective as an antiandrogen. Similarly to spironolactone,<unk>  inhibits steroidogenic enzymes such as 11β-hydroxylase, cholesterol side-chain cleavage enzyme, 17α-hydroxylase, 17,20-lyase, and 21-hydroxylase, but once again, is comparatively less potent in doing so. Pharmacokinetics The elimination half-life of<unk>  is about 16.5 hours. As a metabolite<unk>  is an active metabolite of spironolactone, canrenoic acid, and potassium canrenoate, and is considered to be partially responsible for their effects. It has been found to account for approximately 10 to 25% of the potassium-sparing effect of spironolactone, whereas another metabolite, 7α-thiomethylspironolactone (7α-TMS), accounts for around 80% of the potassium-sparing effect of the drug.
Canrenone
Eplerenone
Spirorenone
Finerenone
7α-Thiospironolactone
Cyclothiazide
Spironolactone
Olmesartan