*Currently, there is no curative treatment for GACI. However, in recent years, better medical treatment has led to increased survival rates. *Use of bisphosphonates appears to significantly increase survival. Etidronate, a non-nitrogen-containing bisphosphonate, is the most commonly used based on its potent antimineralization effect. *Prenatal and postnatal treatment with low-dose, cyclical bisphosphonates, also called diphosphonate, resulted in a complete resolution of vascular calcifications in some cases using disodium pamidronate and risedronate. *Sodium Thiosulfate (STS) is a calcium-chelating agent. It is typically used by patients who have excess calcium in their arteries due to kidney disease. In recent years, STS has also been used to treat patients with GACI.Proposed mechanism of STS action includes chelation or increased solubility of over mineralized calcium in arteries to be removed from the body. STS is typically administered intravenously through a central line in the chest. The dosage amount and length of time for STS treatment is determined by the patient’s medical team. *PGE1 infusion is a possible therapeutic alternative for babies with idiopathic<unk>  calcification complicated by severe hypertension refractory to conventional treatment. *Infants must reach a certain weight to allow for a transplant, commonly not reached. There is minimal information available about heart transplants in patients with GACI. There is some clinical evidence that heart transplants can be successful, without recurrence of calcifications. Heart transplant for individuals with GACI has occurred in at least 3 known cases. In 2014, there was a follow up report about a 4 year old child with GACI who had a successful heart transplant.
Generalized arterial calcification of infancy
Primary familial brain calcification
Hypertension and brachydactyly syndrome
Multifocal fibrosclerosis
Calcinosis cutis
Lipodermatosclerosis
Normolipoproteinemic xanthomatosis
Universal angiomatosis