Release of pro-inflammatory cytokines and activation of the innate immune system may be the result of either external (biological or chemical agents) or internal (genetic mutations/variations) factors. The cytokine Interleukin 6 and C-reactive protein are common inflammatory markers used to diagnose<unk>  risk. Baseline C-reactive protein levels deviate due to natural genetic variation, but significant increases can result from risk factors such as smoking, obesity, lifestyle, and high blood pressure.<unk>  chronic<unk>  increases with age (also known as inflammaging) due to unresolved acute<unk>  and an individual's exposome. Age-related<unk>  chronic<unk>  is associated with several cytokines including CXCL9, TRAIL, interferon gamma, CCL11, and CXCL1, and a proposed measurement of chronic<unk>  based on these cytokines (iAge) correlates with immunosenescence and predicts risk for cardiovascular disease, frailty syndrome, and multimorbidity.
Systemic inflammation
End organ damage
Cytokine storm
Allergic inflammation
Neuroinflammation
Phototoxicity
Tissue stress
Bone marrow suppression