By using T2*-weighted imaging, MRI is able to differentiate distinguishing features of leiomyomas from<unk> s. Investigations by the physician include imaging (ultrasound, CAT scan, MRI) and, if possible, obtaining a tissue diagnosis by biopsy, hysteroscopy, or D&C. Ultimately the diagnosis is established by the histologic examination of the specimen. Typically malignant lesions have >10 mitosis per high power field. In contrast, a<unk>  leiomyoma as a benign lesion would have 5 cm *Stage II: tumor extends beyond the uterus, but within the pelvis :IIA: involves adnexa of uterus :IIB: involves other pelvic tissues *Stage III: tumor infiltrates abdominal tissues :IIIA: 1 site :IIIB: >1 site :IIIC: regional lymph node metastasis *Stage IVA: invades bladder or rectum *Stage IVB: distant metastasis (including intra-abdominal or inguinal lymph nodes; excluding adnexa, pelvic and abdominal tissues) Endometrial stromal<unk> s and<unk>  adenosarcomas are classified as above, with the exception of different classifications for Stage I tumors. *Stage I: the tumor is limited to the uterus :IA: limited to endometrium/endocervix :IB: invades <½ myometrium :IC: invades ≥½ myometrium Finally, malignant mixed Müllerian tumors, a type of carcinosarcoma, are staged similarly to endometrial carcinomas. *Stage I: the tumor is limited to the uterus :IA: invades <½ myometrium :IB: invades ≥½ myometrium *Stage II: invades cervical stroma, but no extension beyond the uterus *Stage III: local and/or regional spread :IIIA: invades<unk>  serosa and/or adnexa :IIIB: vaginal and/or parametrial involvement :IIIC: metastases to pelvic and/or paraaortic lymph nodes ::IIIC1: positive pelvic nodes ::IIIC2: positive para-aortic lymph nodes *Stage IVA: invades bladder and/or bowel mucosa *Stage IVB: distant metastases (including intra-abdominal metastases and/or inguinal lymph nodes)
Uterine sarcoma
Leiomyosarcoma
Uterine adenosarcoma
Endometrial stromal tumour
Endometrial stromal sarcoma
Uterine serous carcinoma
Pelvic lipomatosis
Endometrioid tumor