The natural extraction of<unk>  from Catharanthus roseus is produced at a percent yield of less than 0.0003%. For this reason, alternate methods to produce synthetic<unk>  are being used.<unk>  is created through the semi-synthesis coupling of indole alkaloids<unk> indoline and catharanthine in the<unk> inca plant. It can also now be synthesized through a stereocontrolled total synthesis technique which retains the correct stereochemistry at C18' and C2'. The absolute stereochemistry at these carbons is responsible for<unk> 's anticancer activity. The liposome encapsulation of<unk>  enhances the efficacy of the<unk>  drug while simultaneously decreasing the neurotoxicity associated with it. Liposome encapsulation increases<unk> 's plasma concentration and circulation lifetime in the body, and allows the drug to enter cells more easily.
Vincristine
Ifosfamide
Mitoxantrone
Fludarabine
Cladribine
Etoposide
Lenalidomide
Trifluridine