<unk>  binds irreversibly to epidermal growth factor receptor proteins expressed by EGFR with a T790M mutation; it also binds irreversibly to EGFR with an L858R mutation and with an exon 19 deletion. It exhibits linear pharmacokinetics; the median time to Cmax is 6 hours (range 3–24 hours). The estimated mean half-life is 48 hours, and oral clearance (CL/F) is 14.3 (L/h). 68% of elimination is by feces and 14% by urine.
Osimertinib
Mobocertinib
Lestaurtinib
Upadacitinib
Abrocitinib
Axitinib
Selpercatinib
Icotinib