Overview of RNA interference. Statins Statins have been shown to reduce the<unk>  burden in mouse models, likely due to their anti-inflammatory capacities. Cyclin-dependent kinase 5 Cyclin-dependent kinase 5 (CDK5) is a kinase that has been previously hypothesized to contribute to tau pathologies. RNA interference (RNAi) mediated silencing of the CDK5 gene has been proposed as a novel therapeutic strategy against tau pathology, such as<unk> s. Knockdown of CDK5 has been shown to reduce the phosphorylation of tau in primary neuronal cultures and in mouse models. Furthermore, this silencing showed a dramatic reduction in the number of<unk> s. However, in conditions such as Alzheimer's disease, only about 1% is hereditary, and therefore RNAi therapy may be inadequate for addressing the needs of the majority of those who suffer from this disease. Lithium Lithium has been shown to decrease the phosphorylation of tau. Lithium treatment has been shown to reduce the density of<unk> s in transgenic models in the hippocampus and spinal cord. Despite the decrease in density of<unk> s, motor and memory deficits were not seen to improve following treatment. Additionally, no preventive effects have been seen in patients undergoing lithium treatment. Curcumin Curcumin (as Longvida) has been shown to reduce memory deficit and tau monomers in animal models, however no clinical trials have shown curcumin to remove tau from the brain.
Neurofibrillary tangle
Amyloid plaques
Geographic atrophy
Superficial siderosis
Microinfarct
Lewy body
Wallerian degeneration
Hippocampal sclerosis