<unk>  is quickly and completely absorbed from the gut. Over 90% undergo first-pass metabolism.<unk>  has a plasma half life of about two to four hours, with levels never reaching 1 µg/l in therapeutic doses. The main metabolite is carboxybupranolol, 4-chloro-3-3-(1,1-dimethylethylamino)-2-hydroxy-propyloxybenzoic acid – that is, the methyl group at the benzene ring is oxidized to a carboxyl group –, of which 88% are eliminated renally within 24 hours.
Bupranolol
Propranolol
Brotizolam
Drospirenone
Avacopan
Metergoline
Clonidine
Cabergoline