About one third of children whose mothers are taking this drug during pregnancy typically have intrauterine growth restriction with a small head and develop minor dysmorphic craniofacial features (microcephaly and mental retardation) and limb defects including hypoplastic nails and distal phalanges (birth defects). Heart defects including ventricular septal defect, atrial septal defect, patent ductus arteriosus and coarctation of the aorta may occur in these children. A smaller population will have growth problems and developmental delay, or intellectual disability. Heart defects and cleft lip may also be featured.
Fetal hydantoin syndrome
Fetal trimethadione syndrome
Uremic fetor
Fetal warfarin syndrome
Neonatal encephalopathy
Neonatal sepsis
Neonatal hypocalcemia
Neonatal meningitis