Currently, the exact cause of<unk>  remains unclear. Possible risk factors have been identified that contribute to<unk>  development, which include genetic mutations, hereditary syndrome, renal injuries, and lifestyle factors. Germline mutation of c-MET oncogene and fumarate hydratase gene elevates the risk of type 1 and type 2<unk>  respectively through distinct signaling pathways. Regarding hereditary conditions, patients with hereditary papillary renal cancer syndrome showed a greater risk of type 1<unk> , whereas those with hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome have an increased risk of type 2<unk> . Moreover, patients who experienced chronic kidney diseases or acute kidney injury exhibited a higher incidence of<unk> . Additionally, other risk factors such as smoking, obesity, and high blood pressure can influence the pathogenesis of<unk> .
Papillary renal cell carcinoma
Renal medullary carcinoma
Renal anaplastic sarcoma
Renal medullary fibroma
Renal oncocytoma
Clear cell renal cell carcinoma
Clear cell papillary renal cell carcinoma
Renal cell carcinoma