Below are the common clinical features of those diagnosed with<unk> . Patients will show varying degrees of some or all FHS symptoms. Facial abnormalities are the most defining aspects of those diagnosed with this disease. Cardinal facial features * Triangular face * Deep-set eyes * Short philtrum * Wide mouth with a thin vermilion border of the upper lip * Long nose with a narrow bridge and broad, bulbous base * Low-set ears Voice quality and language * Dysarthria and verbal dyspraxia with phoneme imprecision * Hypernasality * High-pitched voices * Severe receptive and expressive language impairment across all domains of function Bodily features * Significant delay in bone age (-2 SD or greater) with normalization between 6–12 years old * Skeletal anomalies: brachydactyly, broad fingertips or clubbing, clinodactyly, short thumbs, prominent joints, clavicle abnormalities * Short adult stature: for females, maximum height was at the 20th percentile; for males, the maximum height was at the 25th percentile, though male height varied more widely The differential diagnosis of broad thumbs includes Rubinstein-taybi syndrome, where they are a cardinal feature. FHS is also in the differential, which logically agrees with the thought that the disease is a result of a mutation in SRCAP, as this gene interacts with CBP. Behavior * Tantrums during infancy * Attention deficit-hyperactivity disorder (ADHD) during school years: impulsivity, inattention, restlessness * Unpredictable, aggressive outbursts * Autistic spectrum disorder (one case) * Asperger syndrome (one case) * Obsessive compulsive disorder (two cases) Other observations * Intellectual disability: in all cases each individual showed a varying degree of intellectual impairment and learning disability, ranging from borderline normal to moderate intellectual disability * Early entry into puberty is shown in some girls, leading to menorrhagia and irregular periods * Dental problems (caries, malocclusion, dysplastic, small teeth) * Visual impairment
Floating–Harbor syndrome
Cooks syndrome
Johanson–Blizzard syndrome
Mallory–Weiss syndrome
Bloom syndrome
Plummer–Vinson syndrome
Fitz-Hugh–Curtis syndrome
Ogilvie syndrome