People with<unk> /CIM have diffuse, symmetric, flaccid muscle weakness.<unk> /CIM typically develops in the setting of a<unk><unk>  and immobilization, so patients with<unk> /CIM are often receiving treatment in the intensive care unit (ICU). Weakness (motor deficits) occurs in generalized fashion, rather than beginning in one region of the body and spreading. Limb and respiratory (diaphragm) muscles are especially affected. The muscles of the face are usually spared, but in rare cases, the eye muscles may be weakened, leading to ophthalmoplegia. Respiratory difficulties can be caused by atrophy of the muscles between the ribs (intercostals), atrophy of the diaphragm muscle, and degeneration of the nerve that stimulates the diaphragm (phrenic nerve). This can prolong the time it takes to wean a person off of a breathing machine (mechanical ventilation) by as much as 7 – 13 days. Deep tendon reflexes may be lost or diminished, and there may be bilateral symmetric flaccid paralysis of the arms and legs. The nervous system manifestations are typically limited to peripheral nerves, as the central nervous system is usually unaffected.
Critical illness polyneuropathy
Tropical neuropathy
Alcoholic polyneuropathy
Chronic inflammatory demyelinating polyneuropathy
Diabetic neuropathy
Peripheral mononeuropathy
Vasculitic neuropathy
MGUS polyneuropathy