The<unk> <unk>  name abbreviated<unk> ; gene name abbreviated<unk> ,<unk>  or<unk> 1) is a tumor suppressor<unk>  that is dysfunctional in several major cancers. One function of<unk>  is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. When the cell is ready to divide,<unk>  is phosphorylated, inactivating it, and the cell cycle is allowed to progress. It is also a recruiter of several chromatin remodeling enzymes such as methylases and acetylases.<unk>  belongs to the pocket<unk>  family, whose members have a pocket for the functional binding of other<unk> s. Should an oncogenic<unk> , such as those produced by cells infected by high-risk types of human papillomavirus, bind and inactivate<unk> , this can lead to cancer. The<unk>  gene may have been responsible for the evolution of multicellularity in several lineages of life including animals.
Retinoblastoma protein
Myeloma protein
Promyelocytic leukemia protein
Peripheral myelin protein 22
Tumor-associated glycoprotein 72
Retinol-binding protein
Heart-type fatty acid binding protein
Adenovirus E1B protein