Patients usually present with constitutional symptoms (malaise, weight loss, fatigue), and hepatosplenomegaly is commonly found on physical exam. Lymphadenopathy is also found to a lesser extent. Due to the<unk>  nature of the disease, patients may initially present at a more advanced stage, with coagulopathies, hemophagocytic syndrome, and multi-organ failure. Rarely, individuals who have an<unk> <unk>  cell lymphoma that is associated with latent infection with the Epstein-Barr virus (see next section) present with or develop extensive allergic reactions to mosquito bites. The symptoms of these reactions range from a greatly enlarged bite site that may be painful and involve necrosis to systemic symptoms (e.g. fever, swollen lymph nodes, abdominal pain, and diarrhea), or, in extremely rare cases, to life-threatening anaphylaxis.
Aggressive NK-cell leukemia
Precursor T-lymphoblastic lymphoma
Blastic plasmacytoid dendritic cell neoplasm
Angioimmunoblastic T-cell lymphoma
Peripheral T-cell lymphoma
B-cell prolymphocytic leukemia
T-cell prolymphocytic leukemia
Precursor B-cell lymphoblastic leukemia