The mechanism of<unk>  is related to several mutations. The most common abnormalities are t(9;22) and MLL gene rearrangement at 11q23. T(9;22) affect the ABL gene at 9q34 and BCR at 22q11. The hybrid gene product ABL/BCR is an oncogene which could lead several types of<unk>  including<unk> . ABL/BCR could active several molecular pathways: # RAS signaling could be activated by BCR/ABL by GRB2 adaptor which interact with Y177 of BCR. # Through AKT/PKB, PI3-K pathway could also be activated. # STAT5, 1, and 6 has been reported that is a major molecular signaling event activated by BCR/ABL. # Some focal adhesion complex (PAXILLIN, FAK0 could be activated by BCR/ABL with adaptor molecule CRK-L. # BCR/ABL could inactivate negative regulatory molecules PTP1B and Abi-1. Their inactivation is related with progression into blast crisis. # BCR/ABL pathway could also active PI64K/Akt/STAT5 pathway which has anti-apoptotic activity. # BCR/ABL induce cell adhesive and migratory abnormalities because the mutation will lead an abnormal response to chemokine SDF-1 T(9,22) translocation MLL gene encode Histone-lysine N-methyltransferase (HRX), which is a histone methyltransferase. It is a positive regulator for gene transcription. It has been shown that associates with Host cell facor C1, CREB binding protein, WDR5, CTBP, MEN1, etc. The rearrangement of MLL are related with different kinds of aggressive acute<unk> s. Most of<unk> <unk>  in children is due to the rearrangement of MLL Protein MLL PDB 2j2s Besides them, other gene abnormalities has been reported. Such as t(8;21), t(15;17), del(6q), del(12p), t(x;12) and t(14;19). In<unk>  patients, it is prone to bruising, spotting, which is due to megakaryocytes that could produce platelets decrease, resulting in a lack of platelets. Anemia: reduction metrocytes that could produce red blood cells, resulting in a lack of red blood cells. Patients are prone to asthma and dizziness in walking or exercise. Persistent fever, infection prolonged healing: Most of the white blood cells are<unk>  cells, no normal function, leading to decreased immunity, susceptible to infection.
Biphenotypic acute leukaemia
Aggressive NK-cell leukemia
Mixed-phenotype acute leukemia
Leukemoid reaction
Atypical chronic myeloid leukemia
Prolymphocytic leukemia
T-cell prolymphocytic leukemia
B-cell prolymphocytic leukemia