<unk>  lesions, once established, often progress within 24 to 48 hours to full-thickness skin necrosis or soft-tissue necrosis. Once<unk>  lesions progress to full-thickness skin necrosis, healing takes between 4–8 weeks and leaves large scars. Without treatment, necrotic soft tissue may become gangrenous, leading to loss of limbs.<unk>  is often accompanied by micro-vascular thrombosis and haemorrhagic infarction in other tissues, such as the lungs, kidneys, central nervous system and adrenal glands, leading to multiple organ failure, and causes initial high mortality and long-term morbidity in survivors.<unk>  may also lead to severe large vessel venous thrombosis if untreated in its early stages.<unk>  secondary to severe infection is self-limiting. In cases of homozygous protein C deficiency, episodes of<unk>  and other thrombotic events are recurrent. Moreover, infant survival due to maintenance replacement therapy is often associated with mental retardation and/or visual impairment. For post-infection<unk> , new lesions will occur while neutralising autoantibodies are present (1–2 weeks after presentation). A multi-disciplinary care team is usually required for rehabilitation after<unk> .
Purpura fulminans
Acne fulminans
Pyoderma gangrenosum
Leukemia cutis
Visceral larva migrans
Dandruff
Erythema multiforme minor
Ecthyma gangrenosum