Criteria The two main symptoms in a<unk>  are a depressed mood or a loss of interest or pleasure. From the list below, one bold symptom and four other symptoms must be present for a diagnosis of<unk> . These symptoms must be present for at least 2 weeks and must be causing significant distress or impairment in functioning. * Depressed mood * Loss of interest or pleasure * Change in appetite * Change in sleep * Change in body activity (psychomotor changes) * Loss of energy * Feelings of worthlessness and excessive or inappropriate guilt * Indecisiveness or a decrease in concentration * Suicidal ideation To diagnose a<unk> , a trained healthcare provider must make sure that: * The symptoms do not meet the criteria for a mixed<unk> . * The symptoms must cause considerable distress or impair functioning at work, in social settings or in other important areas in order to qualify as an<unk> . * The symptoms are not due to the direct physiological effects of a substance (e.g., abuse of a drug or medication) or a general medical condition (e.g., hypothyroidism). Workup No labs are diagnostic of a depressive<unk> . But some labs can help rule out general medical conditions that may mimic the symptoms of a depressive<unk> . Healthcare providers may order some routine blood work, including routine blood chemistry, CBC with differential, thyroid function studies, and Vitamin B12 levels, before making a diagnosis. Differential diagnosis There are other mental health disorders or medical conditions to consider before diagnosing a<unk> : *Bipolar disorder *Cyclothymic disorder *Disruptive mood dysregulation disorder *Persistent depressive disorder * Anxiety disorder (Generalized anxiety, PTSD, obsessive compulsive disorder) * Substance abuse or Substance Use Disorder * Personality disorder with depressive symptoms * Adjustment disorder * Gender dysphoria * Depression due to a general medical condition * Premenstrual dysphoric disorder
Major depressive episode
Major depressive disorder
Outline of bipolar disorder
Depression 
Late life depression
Atypical depression
Postpartum psychosis
Postpartum depression