<unk>  <unk>  is a form of amyloidosis caused by the<unk>  protein. It was found to be the third most common (~3% of total) cause of amyloidosis in a set of more than 4,000 individuals studied at the Mayo Clinic; the first and second most common forms the disorder were AL amyloidosis and AA amyloidosis, respectively. Amyloidosis is a disorder in which the abnormal deposition of a protein in organs and/or tissues gradually leads to organ failure and/or tissue injury. Although more than 30 different proteins can cause amyloidosis, the disorder caused by<unk>  is distinctive in three ways. First, it has an unusually high incidence in certain ethnic populations. Second, it is a systemic form of amyloidosis (i.e. amyloid deposited in multiple organs), as opposed to a localized form (amyloid deposits limited to a single organ) but nonetheless injures the kidney without or rarely injuring the other organs in which it is deposited. Third,<unk>  is diagnosed almost exclusively in elderly individuals. Given its relatively recent discovery, exceptionally strong ethnic bias, limitation to causing kidney disease, and restriction to elderly individuals,<unk>  appears at present to be an under-recognized cause of chronic kidney disease particularly in the ethnic groups that exhibit a high incidence of the disorder.
LECT2 amyloidosis
AA amyloidosis
AL amyloidosis
Secondary systemic amyloidosis
Anti-AQP4 disease
Sarcoglycanopathy
Hyaluronidase deficiency
Monoclonal gammopathy