The first symptoms of<unk>  are often vague, making diagnosis difficult. Fatigue, loss of appetite, fever, and joint pain are common. Symptoms depend on primary tumor locations and metastases if present: * In the abdomen, a tumor may cause abdominal distension and constipation. * A tumor in the chest may cause breathing problems. * A tumor pressing on the spinal cord may cause weakness, thus an inability to stand, crawl, or walk. * Bone lesions in the legs and hips may cause pain and limping. * A tumor in the bones around the eyes or orbits may cause distinct bruising and swelling. * Infiltration of the bone marrow may cause pallor from anemia.<unk>  often spreads to other parts of the body before any symptoms are apparent, and 50 to 60% of all<unk>  cases present with metastases. The most common location for<unk>  to originate (i.e., the primary tumor) is in the adrenal glands. This occurs in 40% of localized tumors and in 60% of cases of widespread disease.<unk>  can also develop anywhere along the sympathetic nervous system chain from the neck to the pelvis. Frequencies in different locations include: neck (1%), chest (19%), abdomen (30% nonadrenal), or pelvis (1%). In rare cases, no primary tumor can be discerned. Rare but characteristic presentations include transverse myelopathy (tumor spinal cord compression, 5% of cases), treatment-resistant diarrhea (tumor vasoactive intestinal peptide secretion, 4% of cases), Horner's syndrome (cervical tumor, 2.4% of cases), opsoclonus myoclonus syndrome and ataxia (suspected paraneoplastic cause, 1.3% of cases), and hypertension (catecholamine secretion or kidney artery compression, 1.3% of cases).
Neuroblastoma
Ewing's sarcoma
Central neurocytoma
Astroblastoma
Neurothekeoma
Germinoma
Sialoblastoma
Neuroma