M2DS is one of the several types of X-linked intellectual disability. The cause of M2DS is a duplication of the<unk>  or Methyl CpG binding protein 2 gene located on the X chromosome (Xq28). The<unk>  protein plays a pivotal role in regulating brain function. Increased levels of<unk>  protein results in abnormal neural function and impaired immune system. Mutations in the<unk>  gene are also commonly associated with Rett syndrome in females. Advances in genetic testing and more widespread use of Array Comparative Genomic Hybridization has led to increased diagnosis of<unk> . It is thought to represent ~1% of X-linked male mental disability cases. Females affected by this condition often do not show symptoms.
MECP2 duplication syndrome
Cornelia de Lange syndrome
Ayazi syndrome
8p23.1 duplication syndrome
TORCH syndrome
SYNGAP1-related intellectual disability
22q11.2 duplication syndrome
ATR-16 syndrome