<unk>  phases Osteosclerotic phase Ash concentration (mgF/kg) Symptoms and signs Normal Bone 500 to 1,000 Normal Preclinical Phase 3,500 to 5,500 Asymptomatic; slight radiographically-detectable increases in bone mass Clinical Phase I 6,000 to 7,000 Sporadic pain; stiffness of joints; osteosclerosis of pelvis and vertebral column Clinical Phase II 7,500 to 9,000 Chronic joint pain; arthritic symptoms; slight calcification of ligaments' increased osteosclerosis and cancellous bones; with/without osteoporosis of long bones Clinical Phase III 8,400 Limitation of joint movement; calcification of ligaments of neck vertebral column; crippling deformities of the spine and major joints; muscle wasting; neurological defects/compression of spinal cord
Skeletal fluorosis
Dental fluorosis
Vitamin D toxicity
Hyperparathyroidism
Zinc toxicity
Oncogenic osteomalacia
Calcinosis
Hypophosphatasia