Consumption of large amounts of<unk>  can lead to<unk>  poisoning and death; the lethal dose for most adult humans is estimated at 5 to 10 g (which is equivalent to 32 to 64 mg elemental<unk> /kg body weight). Ingestion of<unk>  can produce gastrointestinal discomfort at doses at least 15 to 20 times lower (0.2–0.3 mg/kg) than lethal doses. Chronic intake and topical exposure may cause dental fluorosis, and excess systematic exposure can lead to systemic effects such as skeletal fluorosis. Young children are at risk for receiving excess<unk> , and the American Dental Association (ADA) has recently issued an interim guidance on their<unk>  consumption. In 1974 a three-year-old child swallowed 45 milliliters of 2%<unk>  solution, estimated to be triple the fatal amount, and then died. The<unk>  was administered during his first visit to the dentist, and the dental office was later found liable for the death.
Fluoride therapy
Targeted therapy
Monoclonal antibody therapy
Stereotactic radiation therapy
Carboxytherapy
Radionuclide therapy
Chemoradiotherapy
Radiation therapy