After<unk>  neurons depolarize in response to an odorant, the G-protein mediated second messenger response activates adenylyl cyclase, increasing cyclic AMP (cAMP) concentration inside a cell, which then opens a cyclic nucleotide gated cation channel. The influx of Ca2+ ions through this channel triggers<unk>  adaptation immediately because Ca2+/calmodulin-dependent protein kinase II or CaMK activation directly represses the opening of cation channels, inactivates adenylyl cyclase, and activates the phosphodiesterase that cleaves cAMP. These series of actions by CaMK, desensitizes<unk>  receptors to prolonged odorant exposure. An ORN or an<unk>  Receptor Neuron alert goes off to detect the smell. When the nose is covered taste is a lot harder because the air we breathe goes into the mouth as well. A common idea is that vanilla smells sweet and that is because we taste sweet when we eat vanilla flavorings.
Olfactory fatigue
Auditory fatigue
Olfactory reference syndrome
Auditory processing disorder
Ecotropism
Vibroacoustic disease
Oculomotor nerve palsy
Optic nerve hypoplasia