<unk>  is an aminoketone that belongs to the class of substituted cathinones and the more general class of substituted phenethylamines. The clinically used<unk>  is racemic, that is a mixture of two enantiomers: S-bupropion and R-bupropion. Although the optical isomers on<unk>  can be separated, they rapidly racemize under physiological conditions. There have been reported cases of false-positive urine amphetamine tests in persons taking<unk> . Synthesis It is synthesized in two chemical steps starting from 3'-chloro-propiophenone. The alpha position adjacent to the ketone is first brominated followed by nucleophilic displacement of the resulting alpha-bromoketone with t-butylamine and treated with hydrochloric acid to give<unk>  as the hydrochloride salt in 75–85% overall yield.
Bupropion
Atomoxetine
Hydroxybupropion
Entropion
Citalopram
Duloxetine
Dapoxetine
Fluoxetine