The National Institute of Arthritis and Musculoskeletal and Skin Diseases describes it like this: Normally, our immune system produces antibodies that attack viruses and harmful bacteria to keep us healthy. In people with pemphigus, however, the immune system mistakenly attacks the cells in the epidermis, or top layer of the skin, and the mucous membranes. The immune system produces antibodies against proteins in the skin known as desmogleins. These proteins form the glue that keeps skin cells attached and the skin intact. When desmogleins are attacked, skin cells separate from each other and fluid can collect between the layers of skin, forming blisters that do not heal. In some cases, these blisters can cover a large area of skin.
Pemphigus foliaceus
Pemphigoid nodularis
Giant cell lichenoid dermatitis
Bullous pemphigoid
Pityriasis amiantacea
Pemphigus erythematosus
Pityriasis lichenoides chronica
Mucous membrane pemphigoid