The protein kinase C inhibitor bis(indolyl)maleimide inhibitor<unk>  is clearly seen in the structure of PKCiota (residue 574-turn motif), need to be phosphorylated towards a PKCbeta-specific inhibitor site-directed mutagenesis of the compound for its full activation and co-crystallized as an asymmetric pair which is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) are downstream characteristics of PKCs and PKB/AKT.
BIM-1
AP-7 
HER2/neu
CURB-65
MCN
CARB-X
ONCOS-102
HERG