<unk>  is diagnosed if these three criteria are met: * The patient has been diagnosed with a sarcoma at a young age (below 45). * A first-degree relative has been diagnosed with any cancer at a young age (below 45). * Another first- or a second-degree relative has been diagnosed with any cancer at a young age (below 45) or with a sarcoma at any age. Other criteria have also been proposed: * A proband with any childhood cancer or sarcoma, brain tumor or adrenal cortical carcinoma diagnosed before age 45 * A first- or second-degree relative with a typical LFS malignancy (sarcoma, leukaemia, or cancers of the breast, brain or adrenal cortex) regardless of age at diagnosis * A first- or second-degree relative with any cancer diagnosed before age 60 A third criterion has been proposed: * Two first- or second-degree relatives with LFS-related malignancies at any age.
Li–Fraumeni syndrome
Simpson–Golabi–Behmel syndrome
Weismann-Netter–Stuhl syndrome
Smith–Lemli–Opitz syndrome
Wilson–Turner syndrome
Smith–Magenis syndrome
Ellis–Van Creveld syndrome
Rabson–Mendenhall syndrome