<unk>  is not related to psychosis due to the fact those affected by the<unk>  can easily distinguish their visual disturbances from reality. A vast list of psychoactive substances has been identified and linked with the development of this condition, including lysergamides like LSD and LSA, tryptamines like psilocybin and DMT, phenethylamines like 2C-B, MDMA, MDA and mescaline. Dissociatives such as ketamine and dextromethorphan as well as cannabis and synthetic cannabinoids, salvia divinorum, datura and iboga are also known to trigger<unk> . It is therefore clear that<unk>  is not strictly associated with psychedelic consumption as a number of<unk> -inducing substances may be correlated with its arising. The dosage and how frequent one uses these substances doesn't seem to matter in the development of this condition, since there are several reports in the literature where patients were diagnosed after a single use. This strongly indicates that there may be a genetic predisposition to this condition. It also seems that combining recreational or medical drugs that act on the 5HT2-a receptors, like SSRIs, drastically increases the risk of developing<unk>  due to the drug-drug interaction. The exact pathophysiologic mechanism underlying<unk>  is poorly understood. The primary neurobiological hypothesis is that persistent hallucinations are the result of chronic disinhibition of visual processors and subsequent dysfunction in the central nervous system following consumption of<unk> s. Chronic disinhibition may occur from destruction and/or dysfunction of cortical serotonergic inhibitory interneurons involving the inhibitory neurotransmitter, gamma-aminobutyric acid (GABA). This ultimately can cause disruption of the normal neurological mechanisms that are responsible for filtration of unnecessary stimuli in the brain. On a macroscopic level, the lateral geniculate nucleus (LGN) of the thalamus, which is important in visual processing, has also been implicated in the pathophysiology of<unk> .
Hallucinogen persisting perception disorder
Pollutant-induced abnormal behaviour
Prescription drug addiction
Body substance isolation
Psychedelic microdosing
Long-term effects of cannabis
Bullying in medicine
Effects of meditation