The substance is a mild inducer of the liver enzyme CYP3A4. Some drugs that are metabolized by this enzyme have been shown to be slightly less effective when combined with<unk> , examples including simvastatin and warfarin. It might also be a mild inducer of CYP2B6. On the other hand,<unk>  concentrations in the blood are decreased by drugs that induce CYP2C9 and increased by substances that inhibit this enzyme (such as fluconazole), as well as in people who have genetically determined low CYP2C9 activity. The same may be true of microsomal epoxide hydrolase inhibitors (such as valproic acid). High dose aspirin and related drugs reduce the effectiveness of other anti-gout medications. It is not known conclusively whether this also applies to<unk> , but low dose aspirin does not negatively affect its activity.
Lesinurad
Keldur
Krebiozen
Nicogel
Vagisil
Pegcetacoplan
Itruvone
Custirsen