Although the absorption of<unk>  is small, when used for prolonged periods of time (periods exceeding two weeks), or across a large surface area (total use greater than 50 grams per week), it can have adverse effects. One such effect is the ability of the corticosteroid to suppress the hypothalamic–pituitary–adrenal axis. This can lead to a depression in the release of adrenal hormones such as cortisol and adrenocorticotropic hormone, or ACTH. Symptoms of HPA axis suppression are often subtle and variable, but can often be detected using simple blood or urine tests such at ACTH stimulation test or urinary free cortisol. Those at increased risk for HPA axis suppression are those who are more likely to absorb more of the steroid through the skin. These groups include: *Those who have used topical corticosteroids over a prolonged period of time *Those who have used corticosteroids to cover a large surface area *Those with broken skin barrier or extensive abrasions *Those who have recently undergone stress (such as illness, trauma, surgery) *Children under the age of 12 HPA axis suppression is preventable by supplementation with glucocorticosteroids. If HPA axis suppression occurs, it is often reversed shortly after discontinuation of treatment.
Betamethasone dipropionate
Diflorasone diacetate
Fluticasone furoate
Flumetasone
Flumedroxone acetate
Fluticasone propionate
Clobetasone
Tralomethrin