Macrophage The main source of<unk>  (tumor necrosis factor) are cells in the immune system called macrophages which produce it in response to infection and other stimuli.<unk>  helps activate other immune cells and plays a major role in initiation of inflammation. Individuals with<unk>  have a mutation in the tumor necrosis factor<unk> -1 <unk> R1) gene; the mechanisms by which mutations in<unk> R1 lead to the<unk>  phenotype are still unknown. Impaired shedding of the<unk><unk>  is one of the possible defects, most mutations affect the extracellular domain of the<unk> , some also the cleavage site.
TNF receptor associated periodic syndrome
Marinesco–Sjögren syndrome
Anti-IgLON5 disease
Cryopyrin-associated periodic syndrome
Wiskott–Aldrich syndrome
Antisynthetase syndrome
Sjögren–Larsson syndrome
Hyperimmunoglobulin E syndrome