<unk>  has been shown in animal studies to be a very high potency thienodiazepine. The elimination half-life of<unk>  is 3–6 hours. It is absorbed rapidly after administration; after administration, it is metabolized into active metabolites, one of which is far less potent than<unk>  and the other is only present in very small amounts in the blood and thus the metabolites of<unk>  do not have significant pharmacological effect in humans.<unk>  induces impairment of motor function and has hypnotic properties.<unk>  increases the slow wave light sleep (SWLS) in a dose-dependent manner whilst suppressing deep sleep stages. Less time is spent in stages 3 and 4, which are the deep sleep stages, when GABAergics such as<unk>  are used. Benzodiazepines and thienodiazepines are therefore not ideal hypnotics in the treatment of insomnia. The suppression of deep sleep stages by either may be especially problematic to the elderly as they naturally spend less time in the deep sleep stage.
Brotizolam
Etizolam
Lumasiran
Brinzolamide
Acebutolol
Propranolol
Dorzolamide
Terguride