<unk>  is a rare, autosomal recessive metabolic disorder characterized in infants by bluish urine-stained<unk> s. It is also known as Drummond's syndrome, and hypercalcemia. It is caused by a defect in tryptophan absorption. Bacterial degradation of unabsorbed tryptophan in the intestine leads to excessive indole production and thus to indicanuria which, on oxidation to indigo<unk> , causes a peculiar bluish discoloration of the<unk>  (indoluria). Symptoms typically include digestive disturbances, fever and visual problems. Some may also develop disease due to the incomplete breakdown of tryptophan. It was characterized in 1964, and is associated with the X linked sex gene. Since this syndrome is X linked, the chance for a child to receive normal genes from both parents and be genetically normal for that particular trait is 25%. If an individual receives one normal gene and one gene for the disease, the person will be a carrier for the disease, but usually will not show symptoms. Carrier females usually do not display symptoms of the disorder because it is usually the X chromosome with the abnormal gene that is “turned off”. Parents can undergo genetic testing to see if their child will get this syndrome, but most do not find out until they see the symptoms mentioned below.
Blue diaper syndrome
Anal fistula
Irritant diaper dermatitis
Urogenital fistula
Purple urine bag syndrome
Ascher's syndrome
Rectovaginal fistula
Limb–mammary syndrome