The cause of MPFD is unknown. Current theories suggest an autoimmune cause. It is associated with sepsis, intraventricular haemorrhage of the brain, and necrotising enterocolitis in the baby. It may also be linked to maternal syphilis infection, and antiphospholipid syndrome, among other conditions.
Massive perivillous fibrin deposition
Collagenous spherulosis
Nodular vasculitis
Cerebroretinal microangiopathy with calcifications and cysts
Reactive perforating collagenosis
Platelet-rich fibrin matrix
Granulovacuolar degeneration
Palisaded neutrophilic and granulomatous dermatitis