Drug development Drug metabolism is one of the most important factors to consider when developing new drugs for therapeutic applications. The degradation rate of these new drugs in an organism's system determines the duration and intensity of their pharmacological action. During the past few years,<unk> s have gained a lot of attention in drug development since these enzymes are not readily induced or inhibited by the chemicals or drugs surrounding their environment. CYPs are the primary enzymes involved in drug metabolism. However, recent efforts have been directed towards the development of drug candidates that incorporate functional groups that can be metabolized by<unk> s. By doing this, the number of potential adverse drug-drug interactions is minimized and the reliance on CYP450 metabolism is decreased. Several approaches have been made to screen potential drug interactions. One of them includes human<unk> 3 (hFMO3), which is described as the most vital<unk>  regarding drug interactions. In order to successfully screen hFMO3 in a high throughput fashion hFMO3 was successfully fixed to graphene oxide chips in order to measure the change in electrical potential generated as a result of the drug being oxidized when it interacts with the enzyme. Hypertension There is evidence that<unk> s are associated to the regulation of blood pressure.<unk> 3 is involved in the formation of TMA N-oxides (TMAO). Some studies indicate that hypertension can develop when there are no organic osmolytes (i.e. TMAO) that can counteract an increase in osmotic pressure and peripheral resistance. Individuals with deficient<unk> 3 activity have a higher prevalence of hypertension and other cardiovascular diseases, since there is a decrease in formation of TMA N-oxides to counterbalance the effects of a higher osmotic pressure and peripheral resistance. Fish odor syndrome The trimethylaminuria disorder, also known as fish odor syndrome, causes abnormal<unk> 3-mediated metabolism or a deficiency of this enzyme in an individual. A person with this disorder has a low capacity to oxidize the trimethylamine (TMA) that comes from their diet to its odourless metabolite TMAO. When this happens, large amounts of TMA are excreted through the individual's urine, sweat, and breath, with a strong fish-like odor. As of today, there is no known cure or treatment for this disorder. However, doctors recommend patients to avoid foods<unk>  choline, carnitine, nitrogen, sulfur and lecithin. Other diseases<unk> s have also been associated with other diseases, such as cancer and diabetes. Yet, additional studies are imperative to elucidate what is the relationship between<unk>  function and these diseases, as well as to define these enzymes’ clinical relevance.
Flavin-containing monooxygenase
Flavin containing monooxygenase 1
Biotinidase
Disaccharidase
Transfer factor
Proteases 
Amidase
Xanthine oxidase