<unk>  is a synthetic glucocorticoid used for its anti-inflammatory and immunosuppressive properties.<unk>  is a prodrug; it is metabolised in the liver by 11-β-HSD to<unk> nisolone, the active drug.<unk>  has no substantial biological effects until converted via hepatic metabolism to<unk> nisolone. Pharmacokinetics<unk>  is absorbed in the gastrointestinal tract and has a half life of 2–3 hours. it has a volume of distribution of 0.4–1 L/kg. The drug is cleared by hepatic metabolism using cytochrome P450 enzymes. Metabolites are excreted in the bile and urine. Lodotra "Lodotra" is the trade name of an oral formulation, which releases<unk>  four hours after ingestion. It is indicated for rheumatoid arthritis with morning stiffness. Taken at 10 p.m., it releases the drug at around 2 a.m.. The plasmic peak level is reached at 4 a.m., which is considered to be the optimal time for relieving morning stiffness. The drug was approved in the European Union, in January 2009.
Prednisone
Prednisolone
Methylprednisolone
Methylprednisolone succinate
Methylprednisolone acetate
Etanercept
Cyclofenil
Methylprednisolone aceponate