Diagnosis is suspected when a patient with family history of two of the three classical tumors (medullary thyroid cancer, pheochromocytoma, parathyroid adenoma) or<unk>  presents with one of the classical tumors. It is confirmed by genetic testing for mutation in RET gene. Differences in presentation As noted, all types of<unk>  include pheochromocytoma and medullary thyroid carcinoma.<unk> A is additionally characterized by the presence of parathyroid hyperplasia.<unk> B is additionally characterized by the presence of mucocutaneous neuroma, gastrointestinal symptoms (e.g. constipation and flatulence), and muscular hypotonia.<unk> B can present with a Marfanoid habitus. Classification Before gene testing was available, the type and location of tumors determined which type of<unk>  a person had. Gene testing now allows a diagnosis before tumors or symptoms develop. Comparison of main types of<unk>  endocrine<unk> . A table in the<unk>  endocrine<unk>  article compares the various MEN syndromes.<unk>  and MEN1 are distinct conditions, despite their similar names.<unk>  includes<unk> A,<unk> B and familial medullary thyroid cancer (FMTC). The common feature among the three sub-types of<unk>  is a high propensity to develop medullary thyroid carcinoma. A variant of MEAs 2A was described in 1989. This variant also has patches of cutaneous amyloidosis in the mid/upper back and is inherited in an autosomal dominant fashion.
Multiple endocrine neoplasia type 2
Multiple endocrine neoplasia type 1
Autoimmune polyendocrine syndrome type 1
Autoimmune polyendocrine syndrome type 2
Autoimmune polyendocrine syndrome type 3
McCune–Albright syndrome
Lightwood–Albright syndrome
Late onset congenital adrenal hyperplasia