<unk>  should always be considered in infants and children presenting with hypertension, cardiac failure, or sudden death. Plain radiography, sonography and MRI can aid in the diagnosis. Postnatal gray-scale and color Doppler echocardiographic and sonographic examinations allowed noninvasive diagnosis, assessment of severity, and monitoring of progression. Contrast-enhanced MR angiography with breath-hold and cardiac gating techniques can allow evaluation of the extent of the disease. *Dilated and hypertrophied ventricles *Extramedullary hematopoiesis of liver *Hypertrophy of myocardium *Bright and hyper-reflective myocardium *Periarticular calcifications in the wrists, ears, shoulders, ankles and hip *Heart usually looks structurally normal *Cardiomegaly and pulmonary plethora *Diffuse<unk>  calcification involving aorta, carotid, cerebral, renal, mesenteric and cardiac arteries *Echo-dense aortic annulus, ascending aorta, transverse arch, descending aorta, main pulmonary artery, and coronary arteries unusually. *Abdominal ultrasound can reveal hepatosplenomegaly, ascites, renal echogenicity and diffused<unk>  calcifications involving the aorta, common iliac, splenic, and renal arteries, as well as peritoneal calcifications involving the visceral peritoneum overlying the liver and intestine *Brain ultrasound can show dilated lateral ventricles, poorly developed corpus callosum, and leukomalacia *Echocardiogram can reveal a structurally normal heart, normal ventricular function, however mild concentric ventricular hypertrophy and multiple intracardiac as well as vascular calcifications<unk>  should be suspected when there is hyperechogenicity of vessel walls, evidence of polyhydramnios or a past history of early neonatal deaths. *DNA testing can identify one of the mutations responsible for the condition
Generalized arterial calcification of infancy
Primary familial brain calcification
Hypertension and brachydactyly syndrome
Multifocal fibrosclerosis
Calcinosis cutis
Lipodermatosclerosis
Normolipoproteinemic xanthomatosis
Universal angiomatosis