Generic<unk>  NSAIDs are used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins, which are chemicals that are responsible for pain and the fever and tenderness that occur with inflammation.<unk>  blocks the cyclooxygenase (abbrev. COX) enzymes which form prostanoids, resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced. Post-marketing studies demonstrated that<unk>  inhibition of cyclooxygenase is somewhat COX-2 selective similar to celecoxib and other "COX-2 inhibitors." Unlike rofecoxib, both<unk>  and celecoxib can fully inhibit COX-1 and are designated as having "preferential selectivity" toward COX-2. The R-enantiomer of<unk>  is inactive against COX enzymes, but inhibits beta-catenin levels in hepatoma cells. In the UK,<unk>  is licensed for the treatment of inflammation and pain caused by osteoarthritis and rheumatoid arthritis.
Etodolac
Ketorolac
Tramadol
Desmetramadol
Tapentadol
Ketoprofen
Meloxicam
Pafolacianine