RALD is caused by gain-of-function somatic mutations in the genes NRAS or KRAS. NRAS and KRAS are members of the<unk>  subfamily and are implicated in many types of cancer. Somatic mutations are changes in DNA that occur after conception. Although generally somatic mutations can develop in any cell of the body, in RALD the somatic mutations only reside in the blood cells. Because these mutations are acquired and not in the germline, they cannot be inherited or passed on to children. Function Somatic<unk>  mutations greatly diminish the GTPase activity within the cell. The reduced GTPase activity locks the cells in an activated state and degrades the pro-apoptotic BIM protein, thus making the cells resistant to apoptosis. In contrast to ALPS, this apoptosis defect does not involve the FAS pathway.
RAS-associated autoimmune leukoproliferative disorder
Thymoma-associated multiorgan autoimmunity
Fibrin-associated diffuse large B-cell lymphoma
ALK+ large B-cell lymphoma
Autoimmune lymphoproliferative syndrome
Epstein–Barr virus–associated lymphoproliferative diseases
X-linked lymphoproliferative disease
Nodal marginal zone B cell lymphoma