Chemical structure Complete skeletal formula The compound is a 'second-generation' antisense oligonucleotide; the nucleotides are linked with phosphorothioate linkages rather than the phosphodiester linkages of RNA and DNA, and the sugar parts are deoxyribose in the middle part of the molecule and 2’-O-methoxyethyl-modified ribose at the two ends. These modifications make the drug resistant to degradation by nucleases, allowing it to be administered weekly. The complete sequence is portrayed below: :5’—G*—mC*—mC*—mU*—mC*—dA—dG—dT—dmC—dT—dG—dmC—dT—dT—dmC—G*—mC*—A*—mC*—mC*—3’ :* = 2’-O-(2-methoxyethyl) :m = 5-methyl :d = 2’-deoxy
Mipomersen
Acebutolol
Lumasiran
Eluxadoline
Mitapivat
Fabomotizole
Orlistat
Casimersen