<unk> , sold under the brand name Daraprim among others, is a medication used with leucovorin (leucovorin is used to decrease side effects of<unk> ; it does not have intrinsic anti-parasitic activity) to treat the parasitic diseases toxoplasmosis and cystoisosporiasis. It is also used with dapsone as a second-line option to prevent Pneumocystis jiroveci pneumonia in people with HIV/AIDS. It was previously used for malaria but is no longer recommended due to resistance.<unk>  is taken by mouth. Common side effects include gastrointestinal upset, severe allergic reactions, and bone marrow suppression. It should not be used by people with folate deficiency that has resulted in anemia. There is concern that it may increase the risk of cancer. While occasionally used in pregnancy it is unclear if<unk>  is safe for the baby.<unk>  is classified as a folic acid antagonist. It works by inhibiting folic acid metabolism and therefore the making of DNA.<unk>  was discovered in 1952 and came into medical use in 1953. It is on the World Health Organization's List of Essential Medicines. It was approved as a generic in the United States in February 2020.
Pyrimethamine
Quinine
Artemether
Phenpromethamine
Primaquine
Chloroquine
Mefloquine
Dimetacrine