<unk>  is a synthetic form of the isolated major active metabolite of venlafaxine, and is categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI). When most normal metabolizers take venlafaxine, approximately 70% of the dose is metabolized into<unk> , so the effects of the two drugs are expected to be very similar. It works by blocking the "reuptake" transporters for key neurotransmitters affecting mood, thereby leaving more active neurotransmitters in the synapse. The neurotransmitters affected are serotonin (5-hydroxytryptamine) and norepinephrine (noradrenaline). It is approximately 10 times more potent at inhibiting serotonin uptake than norepinephrine uptake. Transporter KinM IC50 nM SERT 40.2 47.3 NET 558.4 531.3
Desvenlafaxine
Venlafaxine
Sertraline
Fluoxetine
Atomoxetine
Citalopram
Dapoxetine
Imipramine