Main symptoms that may appear in<unk>  The hand of a person with severe<unk>  (on the left, with ring) compared to one without (on the right)<unk>  is considered to be the most common blood disorder. A person with<unk>  may not have any symptoms depending on the underlying cause, and no symptoms may be noticed, as the<unk>  is initially minor, and then the symptoms become worse as the<unk>  worsens. A patient with<unk>  may report feeling tired, weak, decreased ability to concentrate, and sometimes shortness of breath on exertion. If the<unk>  come on quickly, the symptoms often may include, feeling like one is going to pass out, confusion, chest pain, and increased thirstbut if the<unk>  continues slowly (chronic), the body may adapt and compensate for this change; in this case, no symptoms may appear until the<unk>  becomes more severe. If a person becomes<unk> , a set of sign and symptoms may occur, such as feeling tired, weak, feeling like passing out, dizziness, headaches, lack of physical exertion (accompanied by shortness of breath and rapid heartbeat), breathlessness (rapid), difficulty concentrating, irregular heartbeat (fluttering, or rapid heartbeat), cold hands and feet, chest pain, constantly feeling cold, soreness of the tongue, pallor, nausea, poor appetite, easy bruising and bleeding, and muscle weakness. In more severe<unk> , the body may compensate for the lack of oxygen-carrying capability of the blood by increasing cardiac output. The person may have symptoms related to this, such as palpitations, angina (if pre-existing heart disease is present), intermittent claudication of the legs, and symptoms of heart failure. On examination, the signs exhibited may include pallor (pale skin, mucosa, conjunctiva and nail beds), but this is not a reliable sign. A blue coloration of the sclera may be noticed in some cases of iron-deficiency<unk> . There may be signs of specific causes of<unk> , e.g. koilonychia (in iron deficiency), jaundice (when<unk>  results from abnormal break down of red blood cells – in hemolytic<unk> , nerve cell damage (vitamin B12 deficiency), bone deformities (found in thalassemia major) or leg ulcers (seen in sickle-cell disease). In severe<unk> , there may be signs of a hyperdynamic circulation: tachycardia (a fast heart rate), bounding pulse, flow murmurs, and cardiac ventricular hypertrophy (enlargement). There may be signs of heart failure. Pica, the consumption of non-food items such as ice, but also paper, wax, or grass, and even hair or dirt, may be a symptom of iron deficiency, although it occurs often in those who have normal levels of hemoglobin. Chronic<unk>  may result in behavioral disturbances in children as a direct result of impaired neurological development in infants, and reduced academic performance in children of school age. Restless legs syndrome is more common in people with iron-deficiency<unk>  than in the general population.
Anemia
Heart failure
Analbuminaemia
Narcolepsy
Pancytopenia
Basopenia
Osteopenia
Leukopenia