<unk>  (LFS) is rare; as of 2011, cases had been reported in more than 500 families. The syndrome was discovered using an epidemiological approach. Li and<unk>  identified four families in which siblings or cousins of rhabdomyosarcoma patients had a childhood sarcoma, which suggested a familial cancer syndrome. Identification of TP53s the gene affected by mutation was suggested by the same approach. Over half of the cancers in LFS families had been previously associated with inactivating mutations of the p53 gene and in one primary research study, DNA sequencing in samples taken from five<unk>  families showed autosomal dominant inheritance of a mutated TP53 gene.
Li–Fraumeni syndrome
Simpson–Golabi–Behmel syndrome
Weismann-Netter–Stuhl syndrome
Smith–Lemli–Opitz syndrome
Wilson–Turner syndrome
Smith–Magenis syndrome
Ellis–Van Creveld syndrome
Rabson–Mendenhall syndrome