<unk>  describes a state of tiredness that does not resolve with rest or sleep. In general usage,<unk>  is synonymous with extreme tiredness or exhaustion that normally follows prolonged physical or mental activity. When it does not resolve after rest or sleep, or occurs independently of physical or mental exertion, it may be a symptom of a medical condition that may become severe or progressive.<unk>  can be a feature of a mental disorder such as depression; may be associated with conditions of<unk>  pain such as fibromyalgia; it may also feature in conditions of<unk>  low-level inflammation, and be a disease-related symptom in many other conditions.<unk>  often has no known cause, and is recognised as being very complex in nature. Fatigability describes a susceptibility to<unk> . Physical<unk>  results from muscle<unk>  brought about by intense physical activity. Mental<unk>  results from prolonged periods of cognitive activity which impairs cognitive ability. Mental<unk>  can manifest as sleepiness, lethargy, or directed attention<unk> . Mental<unk>  can also impair physical performance.
symptom of Chronic fatigue syndrome
symptom of Fibromyalgia
symptom of Gigantism
symptom of Progeria
symptom of Acne
symptom of Opioid use disorder
symptom of Peptic ulcer disease
symptom of Botulism