<unk>  is a potential treatment for acute or chronic conditions which cause irreversible and severe ("end-stage")<unk>  dysfunction. Since the procedure carries relatively high risks, is resource-intensive, and requires major life modifications after surgery, it is reserved for dire circumstances. Judging the appropriateness/effectiveness of<unk>  transplant on case-by-case basis is critically important (see Contraindications), as outcomes are highly variable.
Liver transplantation
Pancreas transplantation
Hepatoportoenterostomy
Percutaneous hepatic perfusion
Hepatic artery embolization
Biliary endoscopic sphincterotomy
Islet cell transplantation
Pancreatectomy