A 2015 Cochrane systematic review assessing the prevention of chemotherapy-induced oral<unk>  concluded that oral cryotherapy leads to large reductions in the incidence of oral<unk>  of all severities in adults receiving 5-FU treatment for solid cancers. The evidence also indicates a reduction of oral<unk>  in adults receiving high-dose melphalan-based cancer treatment prior to haematopoietic stem cell transplantation, although there is uncertainty regarding the size of the reduction in this instance. No evidence was found for use of this preventive measure in children. Oral cryotherapy involves the placement of rounded ice chips in the mouth, which cools the oral tissues and causes vasoconstriction. This decreases blood flow to the region and, hence, also restricts the amounts of the chemotherapy drugs delivered to the tissues.
Mucositis
Serositis
Myositis
Photosensitivity
Dermatitis
Arthropathy
Leukoedema
Enteropathy