Cases of FA-DLBCL have been treated by surgery; chemotherapy regimens such as CHOP (i.e. cyclophosphamide, hydroxydaunorubicin, oncovin, and prednisone or prednisolone) or R-CHOP (i.e. rituximab plus CHOP); radiotherapy; or a combination of these modalities. Regardless of treatment type, 30 of the 36 cases of FA-DBCL for which there is follow-up results had a benign course with no disease recurrence over 1 to 130 months. All cases arising in pseudocysts had favorable results. Local recurrences of the disease in non-pseudocyst sites did occur but responded to further treatment. Three individuals with disease located in thrombi had serious thromboembolic complications; two of them died from this complication. One individual who had a FA-DLBCL removed from a subdural hematoma developed an Epstein-Barr virus-associated diffuse large B-cell lymphoma (EBV+DLBCL) at a site in the brain near the original hematoma; this case suggests that FA-DLBCL may transform into the far more malignant Epstein-Barr virus-associated lymphoproliferative disease, EBV+ DLBCL. The limited number of FA-DLBCL cases reported as of 2019 does not definitively show which of their treatment(s) is superior. However, the findings do suggest that cases amenable to complete surgical removal are cured by surgery alone and should be considered as an Epstein-Barr positive lymphoproliferative disease while disease in the heart, vasculature, or hematoma may be<unk>  with serious complications and require chemotherapy.
Fibrin-associated diffuse large B-cell lymphoma
Nodal marginal zone B cell lymphoma
Marginal zone B-cell lymphoma
Pediatric-type follicular lymphoma
Diffuse large B-cell lymphoma
Splenic marginal zone lymphoma
Chronic multifocal Langerhans cell histiocytosis
Epstein–Barr virus positive diffuse large B-cell lymphoma, not otherwise specified