<unk> s <unk> s) are substances that modify immune<unk> s. They can be both endogenous (produced naturally within the body) and exogenous (as pharmaceutical drugs), and they can either enhance an immune<unk>  or suppress it. Some of these substances arouse the body's<unk>  to an infection, and others can keep the<unk>  from becoming excessive. Thus they serve as immunomodulators in immunotherapy (therapy that makes use of immune<unk> s), which can be helpful in treating cancer (where targeted therapy often relies on the immune system being used to attack cancer cells) and in treating autoimmune diseases (in which the immune system attacks the self), such as some kinds of arthritis and dermatitis. Most<unk> s are biopharmaceuticals (biologics), including monoclonal antibodies, interleukin 2, interferons, and various types of colony-stimulating factors (e.g., CSF, GM-CSF, G-CSF). "Immunotherapy makes use of<unk> s to enhance the activity of the immune system to increase the body's natural defense mechanisms against cancer", whereas<unk> s for rheumatoid arthritis aim to reduce inflammation. Some of the effects of<unk> s include nausea and vomiting, diarrhea, loss of appetite, fever and chills, muscle aches, weakness, skin rash, an increased tendency to bleed, or swelling. For example, patients with Systemic Lupus Erythematosus (SLE) who are treated with standard of care, including biologic<unk><unk> s, experience a higher risk of mortality and opportunistic infection compared to the general population.
Biological response modifier
Immunologic adjuvant
Therapeutic interfering particle
Monoclonal antibody
Immunotoxin
Immunoconjugate
Generic drug
Prototype drug