Most<unk> ' classification and prognosis are aided by histological evaluation by renal biopsy. The renal biopsy is classically evaluated with light microscopy, electron microscopy, and immunohistology to diagnose a histological pattern, which is then compared to clinical evaluation through history, physical, and laboratory evaluation. The laboratory evaluation usually follows that of a standard nephrology work up and will likely be targeted to a differential diagnosis. Studies focusing on<unk>  often use defined clinical criteria and histological criteria to select patients for research. For example, one study used the following histological criteria: "Glomeruli with<unk>  hypercellularity (four or more cells/mesangium with or without<unk>  matrix expansion and immune complex deposits)". The histologic pattern of injury can also provide insight into the prognosis of the of the glomerular disorder.<unk>  proliferation indicates a mild, though active, lesion. Overall, a kidney biopsy should address the following: * Primary diagnosis, with clinical modifiers * Pattern of injury * Established score/class/grade of disease entities (i.e., lupus nephritis, IgA nephropathy) * Secondary diagnosis (i.e., ATN, interstitial nephritis, thrombotic microangiopathy) * Ancillary studies, if done (i.e., IgG sub typing) * Chronicity grade and score The kidney biopsy is foundational to informing the diagnosis of<unk> , as it is a morphological pattern.
Mesangial proliferative glomerulonephritis
Membranous glomerulonephritis
Minimal mesangial glomerulonephritis
Membranoproliferative glomerulonephritis
Focal proliferative nephritis
Transplant glomerulopathy
Diffuse proliferative nephritis
Rapidly progressive glomerulonephritis