Interactions are important for<unk> s because most T2DM patients are taking many other medications. Gliflozins appear to increase the diuretic effect of thiazides, loop diuretics and related diuretics and may increase the risk of dehydration and hypotension. It is important to adjust the dose of antidiabetics if the treatment is combination therapy to avoid hypoglycemia. For example, interactions with sulfonylureas have led to severe hypoglycemia presumably due to cytochrome P450. A study has shown that it is safe to consume dapagliflozin along with pioglitazone, metformin, glimepiride, or sitagliptin and dose adjustment is unnecessary for either medication. It is unlikely that food intake has clinical meaningful impact on the efficacy of dapagliflozin, therefore it can be administered without regard to meals.
SGLT2 inhibitor
Chloride channel opener
COX-2 inhibitor
CYP17A1 inhibitor
Norepinephrine–dopamine disinhibitor
Beta-adrenergic agonist
Reuptake inhibitor
Protein kinase inhibitor