Management of<unk>  revolves around two goals: 1) diagnose the<unk>  early so that antibiotic prophylaxis can be given to keep an infection from occurring, and 2) educate the patient about his or her condition so that prompt treatment can be given if an infection occurs. Antibiotics Physicians often prescribe the antibiotic trimethoprim-sulfamethoxazole to prevent bacterial infections. This drug also has the benefit of sparing the normal bacteria of the digestive tract. Fungal infection is commonly prevented with itraconazole, although a newer drug of the same type called voriconazole may be more effective. The use of this drug for this purpose is still under scientific investigation. Immunomodulation Interferon, in the form of interferon gamma-1b (Actimmune) is approved by the Food and Drug Administration for the prevention of infection in<unk> . It has been shown to reduce infections in<unk>  patients by 70% and to decrease their severity. Although its exact mechanism is still not entirely understood, it has the ability to give<unk>  patients more immune function and therefore, greater ability to fight off infections. This therapy has been the standard treatment for<unk>  for several years. Hematopoietic stem cell transplantation (HSCT) Hematopoietic stem cell transplantation from a matched donor is curative although not without significant risk.
Chronic granulomatous disease
Common variable immunodeficiency
Wiskott–Aldrich syndrome
Severe combined immunodeficiency
Primary immunodeficiency
X-linked agammaglobulinemia
Selective immunoglobulin A deficiency
SAPHO syndrome