On September 6, 2016, the FDA wrote a letter to Forest Labs requiring a new warning to be added to the label related to a link between the drug and acute pancreatitis and sleep paralysis. After a one-year, open-label study assessing the safety and tolerability of<unk>  in people with major depressive disorder, the most common adverse effects were diarrhea (35.7%), nausea (31.6%), and headache (20.0%); greater than 90% of these adverse effects were mild or moderate. In randomized controlled trials, meanwhile, these rates were 28%, 23.4% and 13.3%, respectively. In contrast to other SSRIs, initial trials showed that<unk>  did not cause decreased sexual desire/function, which often cause people to abandon their use. Additionally,<unk>  may cause less emotional blunting than typical SSRIs and SNRIs. Incidence of adverse effects include: ;Very common adverse effects (incidence >10%): * Nausea * Diarrhea * Headache ;Common adverse effects (1–10% incidence) * Vomiting * Dry mouth * Dizziness * Insomnia ;Uncommon adverse effects (0.1–1% incidence): * Somnolence * Paraesthesia * Tremor * Abnormal dreams * Libido decreased * Restlessness * Akathisia * Restless legs syndrome * Abnormal orgasms (men only) * Delayed ejaculations (men only) * Erectile dysfunction (men only) * Fatigue * Feeling jittery * Palpitations * Ventricular premature contractions * Arthralgia * Increased appetite ;Rare adverse effects (<0.1% incidence): * Serotonin syndrome—a serious adverse effect characterised by: *Nausea *Vomiting *Mental status change (e.g. confusion, hallucinations, agitation, coma, stupor) *Muscle rigidity *Tremor *Myoclonus *Hyperreflexia—overresponsive/overactive reflexes *Hyperthermia—elevated body temperature *Autonomic instability (e.g. tachycardia, dizziness, abnormally excessive sweating, etc.) * Mania/hypomania—a potentially dangerously elated/agitated mood. Every antidepressant has the potential to induce these psychiatric reactions. They are particularly problematic in those with a history of hypomania/mania such as those with bipolar disorder. ;Unknown-incidence adverse effects: * Suicidal ideation—all antidepressants can cause suicidal ideation especially in young adults and adolescents under the age of 25. * Abnormal bleeding—the SSRIs are known for their ability to increase the incidence of gastrointestinal bleeds and other bleeding abnormalities. * Seizures * Syndrome of inappropriate antidiuretic hormone secretion (SIADH)—a condition characterised by an abnormally excessive secretion of antidiuretic hormone causing potentially-fatal electrolyte abnormalities (such as hyponatraemia). * Hyponatraemia (a complication of the former)—low blood sodium. Pregnancy Antidepressant exposure (including<unk>  is associated with shorter average duration of pregnancy (by three days), increased risk of preterm delivery (by 55%), lower birth weight (by 75 g), and lower Apgar scores (by <0.4 points). It is uncertain whether there is an increased rate of septal heart defects among children whose mothers were prescribed an SSRI in early pregnancy.
Vilazodone
Hydrocodone
Nefazodone
Trazodone
Tapentadol
Naltrexone
Tramadol
Norhydrocodone