<unk>  has been found to be well tolerated in clinical trials, with the most common side effects reported when added to surgical or medical castration including fatigue, nausea, abdominal pain, and diarrhea. Other side effects have included rash, falls and bone fractures, and hypothyroidism, as well as seizures (in 0.2%), among others.<unk>  is an expected teratogen and has a theoretical risk of birth defects in male infants if taken by women during pregnancy. It may impair male fertility. When used as a monotherapy (i.e., without surgical or medical castration) in men, NSAAs are known to produce additional, estrogenic side effects like breast tenderness, gynecomastia, and feminization in general by increasing estradiol levels. Similarly to the related second-generation NSAA enzalutamide but unlike first-generation NSAAs like flutamide and bicalutamide, elevated liver enzymes and hepatotoxicity have not been reported with<unk> .
Apalutamide
Darolutamide
Bicalutamide
Nilutamide
Acetothiolutamide
Topilutamide
Flutamide
Enzalutamide