The mechanism for the vasoconstrictor effect is predicted to be mediated by the modulation of calcium influx. This influx of calcium can leads to contraction in the myocytes. Probably the influx of calcium is mediated by the phospholipase C (PLC)-coupled receptors, in rat peripheral artery myocytes. Other research of Sergio Bova et all. has shown that in respiratory, urinary and gastrointestinal smooth muscle there was no contraction by<unk> . The symptoms of<unk>  were very similar to the better known Ca2+ entry blocker agents. Therefore,<unk>  is not only species specific but in addition tissue specific.<unk>  has a strong effect on the mitochondria in the cell. Therefore,<unk>  transfer through the outer mitochondrial membrane (OMM) to the inner mitochondrial space. At this location or at the matrix it induce the permeability transition pore (PTP). This PTP is an inner mitochondrial membrane (IMM) channel, whose opening leads to an increasing permeability for ions with an exclusion size of about 1500 Da. The transport of<unk>  comes from a translocation protein (TSPO) also known as peripheral benzodiazepine receptor. The TSPO is selective for the<unk>  transport in rats. In figure 6.1 shows the crucial alignment of rat, mouse and guinea pig LPSO. There are a few differences in amino acids, but the position of 113 is very similar in between the species and other species like dogs, humans and chickens. Where the rat have at position 113 a methionine (M) others species have a leucine amino acid. This results probably for the different amount of transport between rat and other species.
Norbormide
Nandrolone caproate
Nandrolone
Norethandrolone
Nandrolone hydrogen succinate
Nandrolone propionate
Nandrolone sulfate
Oxandrolone