Electroencephalogram of a person with suspected CJD showing typical periodic bursts of triphasic sharp waves Definitive Examination of brain tissue is required to confirm a diagnosis of<unk>  CJD. The following confirmatory features should be present: * Numerous widespread kuru-type amyloid plaques surrounded by vacuoles in both the cerebellum and cerebrum<unk>  florid plaques. * Spongiform change and extensive prion protein deposition shown by immunohistochemistry throughout the cerebellum and cerebrum. Suspected * Current age or age at death less than 55 years (a brain autopsy is recommended, however, for all physician-diagnosed CJD cases). * Psychiatric symptoms at illness onset and/or persistent painful sensory symptoms (frank pain and/or dysesthesia). * Dementia, and development ≥4 months after illness onset of at least two of the following five neurologic signs: poor coordination, myoclonus, chorea, hyperreflexia, or visual signs. (If persistent painful sensory symptoms exist, ≥4 months' delay in the development of the neurologic signs is not required). * A normal or an abnormal EEG, but not the diagnostic EEG changes often seen in classic CJD. * Duration of illness of over 6 months. * Routine investigations do not suggest an alternative, non-CJD diagnosis. * No history of getting human pituitary growth hormone or a dura mater graft from a cadaver. * No history of CJD in a first degree relative or prion protein gene mutation in the person. Classification<unk>  is a separate condition from classic<unk><unk><unk><unk>  (though both are caused by PrP prions). Both classic and<unk>  CJD are subtypes of<unk><unk><unk><unk> . There are three main categories of CJD<unk> : sporadic CJD, hereditary CJD, and acquired CJD, with<unk>  CJD being in the acquired group along with iatrogenic CJD. The classic form includes sporadic and hereditary forms. Sporadic CJD is the most common type. ICD-10 has no separate code for<unk>  and such cases are reported under the<unk><unk><unk><unk>  code (A81.0).
Variant Creutzfeldt–Jakob disease
Powassan encephalitis
Autoimmune encephalitis
Saint Louis encephalitis
Viliuisk encephalomyelitis
Japanese encephalitis
Anti-NMDA receptor encephalitis
Herpesviral encephalitis