<unk>  is caused by mutations in the ITGB2 gene which are inherited autorecessively. This gene encodes CD18, a protein present in several cell surface receptor complexes found on white blood cells, including lymphocyte function-associated antigen<unk>  (LFA-1), complement receptor 3 (CR-3), and complement receptor 4 (CR-4). The deficiency of LFA-1 causes neutrophils to be unable to adhere to and migrate out of blood vessels, so their counts can be high. It also impairs immune cell interaction, immune recognition, and cell-killing lymphocyte functions. The lack of CR3 interferes with chemotaxis, phagocytosis, and respiratory burst
Leukocyte adhesion deficiency-1
MBL deficiency
Rh deficiency syndrome
X linked thrombocytopenia
Severe combined immunodeficiency
Myeloperoxidase deficiency
SAPHO syndrome
Common variable immunodeficiency