* Food and drugs containing large amounts of calcium, magnesium or aluminium (antacids) decrease the absorption of alendronate. At least half an hour should pass after intake of alendronate before eating dairy products or taking the supplement or drug. * Highly active vitamin D analogues or fluorides: no data is available. Concomitant treatment should be avoided. * The additional beneficial effect of HRT (hormone replacement therapy) with estrogens/progestins or raloxifene in postmenopausal women with osteoporosis remains to be elucidated, but no interactions have been seen. The combination is therefore possible, but controversial. * Intravenous ranitidine increases the oral bioavailability of alendronate. No clinical consequences are known. * The combination of NSAIDs and alendronate may increase the risk of gastric ulcers. Both these drugs have the potential to irritate the upper gastro-intestinal mucosa.
Alendronic acid
Medronic acid
Risedronic acid
Pamidronic acid
Zoledronic acid
Etidronic acid
Ibandronic acid
Denosumab