<unk>  results from the overproduction of glucagon, a peptide hormone located in the pancreatic alpha cells. Classic symptoms include, but are not limited to, necrolytic migratory erythema (NME), diabetes mellitus, and weight loss. NME presents in about 70% of cases of<unk> , and is characterized by erythematous lesions over the distal extremities and the groin area. NME has occasionally been observed in people who do not have<unk> . People who develop<unk>  from Mahvash disease also do not develop NME, implying that working glucagon receptors are needed in order for NME to be present in a person. Weight loss, the most commonly associated effect with<unk> , results from the glucagon hormone, which prevents the uptake of glucose by somatic cells. Diabetes is not present in all cases of<unk> , but does frequently result from the insulin and glucagon imbalance.
Glucagonoma
Insulinoma
Somatostatinoma
Metastatic insulinoma
VIPoma
Idiopathic hypoglycemia
Hibernoma
Gastrinoma