<unk>  <unk> , is a rare autosomal recessive congenital disorder causing chromosomal instability, probably as a result of a defect in the double Holliday junction DNA repair mechanism and/or the synthesis dependent strand annealing mechanism for repairing double strand breaks in DNA (see Homologous recombination).<unk> 1 codes for a protein (nibrin) that has two major functions: (1) to stop the cell cycle in the S phase, when there are errors in the cell DNA (2) to interact with FANCD2 that can activate the BRCA1/BRCA2 pathway of DNA repair. This explains why mutations in the<unk> 1 gene lead to higher levels of cancer (see Fanconi anemia, Cockayne syndrome.) The name derives from the Dutch city<unk> , where the condition was first described. Most people with<unk>  have West Slavic origins. The largest number of them live in Poland.
Nijmegen breakage syndrome
Peutz–Jeghers syndrome
Mismatch repair cancer syndrome
Warsaw breakage syndrome
MUTYH-associated polyposis
Letterer–Siwe disease
Sturge–Weber syndrome
Van Den Bosch syndrome