<unk> is the leakage of intravenously (IV) infused, and potentially damaging, medications into the extravascular tissue around the site of infusion. The leakage can occur through brittle veins in the elderly, through previous venipuncture access, or through direct leakage from wrongly positioned venous access devices. When the leakage is not of harmful consequence it is known as infiltration.<unk> of medication during intravenous therapy is an adverse event related to therapy that, depending on the medication, amount of exposure, and location, can potentially cause serious injury and permanent harm, such as tissue necrosis. Milder consequences of<unk> include irritation, characterized by symptoms of pain and inflammation, with the clinical signs of warmth, erythema, or tenderness.
Extravasation 
Intravasation
Lymphangiogenesis
Vasculogenesis
Vascular permeability
Vascular recruitment
Thromboregulation
Neovascularization