Adverse effects of<unk> s have been linked to many disease states and conditions ranging from schizophrenia, major depression and Alzheimer's disease to cancer. T regulatory cells (Tregs) and related-cytokines are effectively engaged in the process of tumor immune escape and functionally inhibit immune response against the tumor. Forkhead box protein 3 (Foxp3) as a transcription factor is an essential molecular marker of Treg cells. Foxp3 polymorphism (rs3761548) might be involved in cancer progression like gastric cancer through influencing Tregs function and the secretion of immunomodulatory<unk> s such as IL-10, IL-35, and TGF-β. Normal tissue integrity is preserved by feedback interactions between diverse cell types mediated by adhesion molecules and secreted<unk> s; disruption of normal feedback mechanisms in cancer threatens tissue integrity. Over-secretion of<unk> s can trigger a dangerous<unk>  storm syndrome.<unk>  storms may have been the cause of severe adverse events during a clinical trial of TGN1412.<unk>  storms are also suspected to be the main cause of death in the 1918 "Spanish Flu" pandemic. Deaths were weighted more heavily towards people with healthy immune systems, because of their ability to produce stronger immune responses, with dramatic increases in<unk>  levels. Another example of<unk>  storm is seen in acute pancreatitis.<unk> s are integral and implicated in all angles of the cascade, resulting in the systemic inflammatory response syndrome and multi-organ failure associated with this intra-abdominal catastrophe. In the COVID-19 pandemic, some deaths from COVID-19 have been attributable to<unk>  release storms. Current data suggest<unk>  storms may be the source of extensive lung tissue damage and dysfunctional coagulation in COVID-19 infections.
Cytokine
Lymphokine
Hormone
Inflammatory cytokine
Gastrointestinal hormone
Neurohormone
Xenohormone
Antibody