<unk> 's disease is a skin disorder that causes a discoloration of the lower extremities. It usually occurs in the lower extremities and rarely elsewhere. This condition is caused by leaky blood vessels near the surface of the skin. The cause of the leaky capillaries is usually not known. When the red blood cells escape the blood vessels, they end up close under the skin surface, where they break apart, releasing hemoglobin, which in turn breaks apart, releasing Iron. (Iron is the part of hemoglobin that enables it to transfer oxygen from the lungs to the cells and carbon dioxide from the cells to the lungs.) The iron released into the skin gets bound up into a complex called hemosiderin, which causes the discoloration of the skin. Diagnosis == With a complete history, the results from visual examination, and the aid of appropriate laboratory testing, a dermatologist can usually determine whether the skin lesions are in fact due<unk> 's disease.<unk> 's disease can only be properly diagnosed by a healthcare provider. For a trained skin specialist such as a dermatologist, the condition is often readily diagnosed, because the visual appearance of the lesions on the skin itself usually suggests the possibility that the cause may be<unk> 's disease. While reviewing medical history is important to diagnose this condition, it is essential that the skin be physically examined. To ensure that the skin lesions are not caused by other skin conditions or infections, a doctor will often order a complete blood count (CBC) and other blood tests. Blood test results are usually normal. They are performed primarily to rule out other bleeding disorders that cause purpura. Since<unk> 's disease is usually asymptomatic beyond the visible lesions themselves, few other tests are usually indicated. Micrograph of<unk> , suggesting the spongiotic stage of a purpuric dermatitis. Additional testing may aid diagnosis. A skin biopsy may be taken to determine capillaritis of dermal vessels. Capillaritis or pigmented purpura is skin condition that has brown-reddish patches on the skin, which is caused by leaky capillaries. Such skin biopsies are sent to a laboratory for a pathological examination, where each biopsy is observed under a microscope. A dermatologist may also perform a dermatoscopy.
Schamberg disease
Keshan disease
Binswanger's disease
Camurati–Engelmann disease
Camisa disease
Kyrle disease
Kikuchi disease
Schindler disease