<unk>  has an autosomal recessive pattern of inheritance. The genetic background of this disease has been linked to a gene called FRAS1, which seems to be involved in skin epithelial morphogenesis during early development. It has also been associated with FREM2 and with GRIP1. Mapping By autozygosity mapping, McGregor et al. (2003) located the<unk>  locus to chromosome 4q21. Genetic Heterogeneity In 6 of 18 consanguineous families with<unk> , van Haelst et al. (2008) excluded linkage to both the FRAS1 and FREM2 genes, indicating genetic heterogeneity.
Fraser syndrome
Townes–Brocks syndrome
Rosselli–Gulienetti syndrome
Griscelli syndrome
Lucey–Driscoll syndrome
Laugier–Hunziker syndrome
Barakat-Perenthaler syndrome
Romano–Ward syndrome