A<unk>  is an abnormal growth of tissue in<unk> , traditionally classified as noncancerous (benign) or cancerous (malignant). Cancerous<unk> s usually originate from a cancer in another part of the body such as from lung, breast, thyroid, kidney and prostate. There may be a lump, pain, or neurological signs from pressure. A<unk>  might present with a pathologic fracture. Other symptoms may include fatigue, fever, weight loss, anemia and nausea. Sometimes there are no symptoms and the<unk> r is found when investigating another problem. Diagnosis is generally by X-ray and other radiological tests such as CT scan, MRI, PET scan and<unk>  scintigraphy. Blood tests might include a complete blood count, inflammatory markers, serum electrophoresis, PSA, kidney function and liver function. Urine may be sent for Bence Jones protein. For confirmation of diagnosis, a biopsy for histological evaluation might be required. The most common<unk>  is a non-ossifying fibroma. Average five-year survival in the United States after being diagnosed with<unk>  and joint cancer is 67%. The earliest known<unk>  was an osteosarcoma in a foot<unk>  discovered in South Africa, between 1.6 and 1.8 million years ago.
Bone tumor
Bone metastasis
Osteomyelitis
Osteoma
Endocrine bone disease
Spinal fracture
Osteopetrosis
Vertebral osteomyelitis