There are no certain interactions with other drugs. The blood plasma levels of simvastatin were reduced by 57% after a single dose of<unk> , but it is not known whether this is clinically relevant. A possible mechanism is that the elevated IL-6 levels of patients with rheumatoid arthritis suppress the biosynthesis of various cytochrome P450 enzymes, notably CYP1A2, CYP2C9, CYP2C19 and CYP3A4.<unk>  lowers IL-6 and thus normalises cytochrome levels, increasing the metabolization of simvastatin (and possibly other cytochrome metabolised drugs).
Tocilizumab
Satralizumab
Brolucizumab
Ixekizumab
Caplacizumab
Atezolizumab
Reslizumab
Risankizumab