<unk>  takes different approaches depending on physical and biological characteristics of the disease, as well as the age, over-all health and personal preferences of the patient. Treatment types can be classified into local therapy (surgery and radiotherapy) and systemic treatment (chemo-, endocrine, and targeted therapies). Local therapy is most efficacious in early stage<unk><unk> , while systemic therapy is generally justified in advanced and metastatic disease, or in diseases with specific phenotypes. Historically,<unk><unk>  was treated with radical surgery alone. Advances in the understanding of the natural course of<unk><unk>  as well as the development of systemic therapies allowed for the use of<unk> -conserving surgeries, however, the nomenclature of viewing non-surgical<unk>  from the viewpoint of the definitive surgery lends to two adjectives connected with treatment timelines: adjuvant (after surgery) and neoadjuvant (before surgery). The mainstay of<unk>  is surgery for the local and regional tumor, followed (or preceded) by a combination of chemotherapy, radiotherapy, endocrine (hormone) therapy, and targeted therapy. Research is ongoing for the use of immunotherapy in<unk> .<unk>  of<unk><unk>  is undertaken by a multidisciplinary team, including medical-, radiation-, and surgical- oncologists, and is guided by national and international guidelines. Factors such as treatment, oncologist, hospital and stage of your<unk><unk>  decides the cost of<unk><unk>  one must pay.
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