The median age at diagnosis is 38 years. An estimated 1-3% of<unk><unk> s are associated with hereditary<unk>  syndromes.<unk>  is the most common hereditary<unk>  syndrome of the stomach.<unk>  was originally discovered through studies of Maori families in New Zealand that were noted to have increased incidences of<unk><unk> . Detection of CDH1 mutations causing<unk>  is highest in countries with low incidences of<unk><unk> , such as the United States and Canada. Conversely, detection of CDH1 mutations is lowest in countries with high rates of<unk><unk> , such as Portugal, Italy, and Japan. For this reason, some have pushed for increased genetic screening in countries with high rates of<unk><unk> , as the rates may mask the incidence of CDH1 mutations.
Hereditary diffuse gastric cancer
Hereditary nonpolyposis colorectal cancer
Juvenile polyposis syndrome
Coeliac disease
Tropical sprue
Attenuated familial adenomatous polyposis
Familial adenomatous polyposis
Serrated polyposis syndrome