It is contraindicated if there has been a past history of angioedema; heart conduction disorders (e.g. sick sinus syndrome, second- or third-degree heart block); bradycardia; severe heart failure or coronary artery disease. Also: Raynaud's syndrome, intermittent claudication, epilepsy, depression, Parkinson's disease, glaucoma. Use in pregnancy is discouraged.<unk>  passes into breast milk. Excess mortality has been seen in patients with symptomatic heart failure in the<unk> CON study. However, the<unk> CON trial utilised a very high dose of 3.0 mg daily which is well above the normal dose of 0.2–0.6 mg daily.
Moxonidine
Pramocaine
Carctol
Ibogaine
Bromelain 
Iontocaine
Tesofensine
Lofexidine