Cancer diagnosis A specific change to the conformation of albumin molecules that is associated with the growth of a malignant tumor is caused by (or associated with) changes in the composition of metabolites carried by serum albumin during the growth of a malignant tumor (proliferating cancer cells uptake and release metabolites in abnormal quantities). Clinical studies of the<unk>  test of serum albumin showed diagnostic sensitivity and specificity of 90%. Clinical applications: * as a screening test to detect cancer-specific metabolic alterations in patients; * to determine whether the cancer growth has stopped or the disease is progressing; * to determine when cancer treatment is effective or needs to be changed. Sepsis and toxemia Reduced<unk> al activity of serum albumin (reduced binding efficacy) is associated with toxemia (an increase in the concentration of toxic molecules in the blood) and is manifested before other clinical symptoms. Clinical applications: * prognosis and early diagnosis of sepsis (1 to 2 hours after surgery); * diagnosis of severe preeclampsia (gestosis) in women in the 2nd and 3rd trimesters of pregnancy; * diagnostics of the<unk> al status of a kidney transplant * early diagnosis of congenital pneumonia in newborns. References
Albumin transport function analysis by EPR spectroscopy
United Kingdom Model for End-Stage Liver Disease
Serum total protein
Serum-ascites albumin gradient
Urine organic acids
Euglobulin lysis time
Evans formula
Reticulocyte production index