<unk>  has been described as an indolent condition. Although possibly based on opinion rather than on objective assessments, symptoms, if any, are commonly described as mild in the medical literature. This can be in spite of considerable underlying organ destruction. People are often described as being generally well at the time of diagnosis, although some may give a history of weight loss. Pain is generally not a feature of inflammation. However, it may occur as a secondary effect, for example, due to either obstruction or compression. Often diagnosis is made due to the presence of painless swellings or mass lesions, or due to complications of masses, e.g. jaundice due to involvement of the pancreas, biliary tree or liver. Symptoms are commonly attributed to other conditions and other diagnoses may have been made years before diagnosis, e.g. urinary symptoms in men attributed to common prostate conditions. Lesions may also be detected incidentally on radiological images, but can be easily misdiagnosed as malignancies. Reported cases do include some significant symptoms or findings however: System Uncommon symptoms and complications Neurological Seizures, paralysis or hemiparesis, cranial nerve palsies, sensorineural hearing loss, pituitary hormone deficiencies Eye Loss of vision, proptosis Cardiovascular Constrictive pericarditis, heart block, ruptured aortic aneurysm, aortic dissection, carotid artery dissection, intracranial aneurysm, angina, sudden cardiac death Respiratory Airway obstruction, pleural effusion Gastrointestinal Esophageal obstruction, bowel obstruction Urological Renal failure, hydronephrosis, testicular pain Individual organ manifestations<unk>  can involve one or multiple sites in the body. With multiorgan involvement, the sites involved can be affected at the same time (synchronously) or at different unrelated periods (metachronously). Several different diseases that have been known for many years are now considered to be manifestations of<unk> . These include: type 1 autoimmune pancreatitis, interstitial nephritis, Riedel's thyroiditis, Mikulicz's disease, Küttner's tumor, inflammatory pseudotumors (in various sites of the body), mediastinal fibrosis and some cases of retroperitoneal fibrosis. Nomenclature for individual organ involvement Organ or site Preferred names Previously used names Head and neck Salivary gland IgG4-related sialadenitis: : IgG4-related submandibular gland disease, : IgG4-related parotitis Mikulicz's disease (salivary and lacrimal glands), chronic sclerosing sialadenitis, Küttner's tumour (submandibular glands) Orbit IgG4-related ophthalmic disease (IgG4-ROD) including: : IgG4-related dacryoadenitis (lacrimal glands), : IgG4-related orbital inflammation (or IgG4-related orbital inflammatory pseudotumor), : IgG4-related orbital myositis (extraocular muscles), : IgG4-related pan-orbital inflammation Mikulicz's disease (salivary and lacrimal glands), Idiopathic orbital inflammatory disease, orbital pseudotumor Paranasal sinuses Chronic sinusitis, Eosinophilic angiocentric fibrosis (upper respiratory tract and orbit) Pharynx IgG4-related pharyngitis Thyroid gland IgG4-related thyroid disease Riedel's thyroiditis, Riedel's struma Soft tissues of the head and neck Idiopathic cervical fibrosis, sclerosing cervicitis, cervical fibrosclerosis Central Nervous System Pituitary gland IgG4-related hypophysitis: : IgG4-related panhypophysitis (all of pituitary gland), : IgG4-related adenohypophysitis (anterior pituitary), : IgG4-related infundibuloneurohypophysitis (posterior pituitary and pituitary stalk) Autoimmune hypophysitis Meninges IgG4-related pachymeningitis (dura mater),IgG4-related leptomeningitis (arachnoid and pia mater) Idiopathic hypertrophic pachymeningitis Chest and abdomen Pancreas IgG4-related pancreatitis Type 1 autoimmune pancreatitis, lymphoplasmacytic sclerosing pancreatitis, 'chronic pancreatitis with diffuse irregular narrowing of the main pancreatic duct' Lung IgG4-related lung disease Pulmonary inflammatory pseudotumour Pleura IgG4-related pleuritis Liver IgG4-related hepatopathy Bile duct IgG4-related sclerosing cholangitis Gallbladder IgG4-related cholecystitis Aorta(especially the infrarenal portion) IgG4-related aortitis,IgG4-related periaortitis Inflammatory aortic aneurysm,Chronic sclerosing aortitis, chronic periaortitis. Branches of the aorta(including coronary, renal or iliac arteries) IgG4-related periarteritis Pericardium IgG4-related pericarditis Mediastinum IgG4-related mediastinitis Fibrosing mediastinitis, chronic sclerosing mediastinitis Retroperitoneum IgG4-related retroperitoneal fibrosis Retroperitoneal fibrosis, Albarran-Ormond syndrome, Ormond's disease, perirenal fasciitis, Gerota's fasciitis/syndrome, periureteritis fibrosa, sclerosing lipogranuloma, sclerosing retroperitoneal granuloma, non-specific retroperitoneal inflammation, sclerosing retroperitonitis, retroperitoneal vasculitis with perivascular fibrosis. Mesentery IgG4-related mesenteritis (subtypes are: mesenteric panniculitis, mesenteric lipodystrophy and retractile mesenteritis) Sclerosing mesenteritis, systemic nodular panniculitis, liposclerosis mesenteritis, mesenteric Weber–Christian disease, mesenteric lipogranuloma, xanthogranulomatous mesenteritis. Breast IgG4-related mastitis Sclerosing mastitis Genitourinary Kidney IgG4-related kidney disease (IgG4-RKD): : IgG4-related tubulointerstitial nephritis (IgG4-TIN), : membranous glomerulonephritis secondary to<unk> , : IgG4-related renal pyelitis (renal pelvis) Idiopathic tubulointerstitial nephritis Prostate IgG4-related prostatitis Vas deferens IgG4-related perivasal fibrosis Chronic orchialgia Scrotum IgG4-related paratesticular pseudotumor,IgG4-related epididymo-orchitis Paratesticular fibrous pseudotumor, inflammatory pseudotumor of the spermatic cord, pseudosarcomatous myofibroblastic proliferations of the spermatic cord, proliferative funiculitis, chronic proliferative periorchitis, fibromatous periorchitis, nodular periorchitis, reactive periorchitis, fibrous mesothelioma Other Lymph nodes IgG4-related lymphadenopathy Skin IgG4-related skin disease Angiolymphoid hyperplasia with eosinophilia, cutaneous pseudolymphoma Nerve IgG4-related perineural disease This is not a complete list, as<unk>  can involve any site in the body. Other affected sites, confirmed on histology to be manifestations of<unk> , include: heart; hard palate, esophagus, stomach, small intestine, rectum, adrenal gland, ovary, uterus, ureter, bladder, urachus, and synovium. Approximately 1/3 of cases exhibit increases in blood eosinophil counts, either eosinophilia or hypereosinophilia. Radiologic evidence suggestive of involvement of the superior vena cava and seminal vesicle has been reported in confirmed cases of<unk> .
IgG4-related disease
IgG4-related skin disease
Anti-IgLON5 disease
IgA vasculitis
Isolated primary immunoglobulin M deficiency
Antisynthetase syndrome
Undifferentiated connective tissue disease
Leukotriene receptor antagonist-associated Churg–Strauss syndrome