Estradiol, the active form of<unk> . Pharmacodynamics<unk>  is an estradiol ester, or a prodrug of estradiol. As such, it is an estrogen, or an agonist of the estrogen receptors.<unk>  is of about 41% higher molecular weight than estradiol due to the presence of its C3 and C17β propionate esters. Because<unk>  is a prodrug of estradiol, it is considered to be a natural and bioidentical form of estrogen. Pharmacokinetics Compared to estradiol benzoate, a related estradiol ester,<unk>  has enhanced and prolonged effects. Whereas the duration of action of estradiol benzoate is said to be 2 to 3 days, the duration of<unk>  has been said to be 1 to 2 weeks. However, newer estradiol esters have longer durations than either estradiol benzoate or<unk> ; the duration of estradiol valerate has been said to be 1 to 3 weeks, and the duration of estradiol cypionate has been said to be 3 to 4 weeks. A single intramuscular injection of 5 mg<unk>  has a duration of about 5 to 8 days. A single intramuscular injection of 50 μg/kg<unk>  in oil in 15 pubertal girls (about 1 mg for a 50-kg (110-lb) girl) was found to produce peak estradiol levels of about 215 pg/mL after 1.5 days. Estradiol levels declined to about 90 pg/mL after 4 days.
Estradiol dipropionate
Estradiol furoate
Estradiol undecylate
Estradiol hemisuccinate
Estradiol valerate
Estradiol dienantate
Estradiol enantate
Estradiol diundecylenate