<unk> , a non-heme iron protein, acts by induction of DNA strand breaks. Some studies suggest<unk>  also inhibits incorporation of thymidine into DNA strands. DNA cleavage by<unk>  depends on oxygen and metal ions, at least in vitro. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that<unk>  chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. An alternative hypothesis states that<unk>  may bind at specific sites in the DNA strand and induce scission by abstracting the hydrogen atom from the base, resulting in strand cleavage as the base undergoes a Criegee-type rearrangement, or forms an alkali-labile lesion. In addition, these complexes also mediate lipid peroxidation and oxidation of other cellular molecules. Therefore,<unk>  is used in combination with doxorubicin in Hodgkins lymphoma, as they have additive and complementary effects on the DNA, since doxorubicin acts by intercalating between DNA strands, and also acts on topoisomerase II enzyme thus relaxing the topoisomerase complexes.
Bleomycin
Ifosfamide
Vincristine
Doxorubicin
Epirubicin
Etoposide
Mitoxantrone
Daunorubicin