Lymph node with<unk>  (low power view, H&E)<unk> . Notice the irregular nuclear contours of the medium-sized<unk>  cells and the presence of a pink histiocyte. By immunohistochemistry the<unk>  cells expressed CD20, CD5 and Cyclin D1 (high power view, H&E) Micrograph of terminal ileum with<unk>  (bottom of image). H&E stain. Micrograph of terminal ileum with<unk>  (bottom of image - brown colour). Cyclin D1 immunostain. Diagnosis generally requires stained slides of a surgically removed part of a lymph node. Other methods are also commonly used, including cytogenetics and fluorescence in situ hybridization (FISH). Polymerase chain reaction (PCR) and CER3 clonotypic primers are additional methods, but are less often used. The immunophenotype profile consists of CD5+ (in about 80% of cases), CD10-/+, and it is usually CD5+ and CD10-. CD20+, CD23-/+ (though plus in rare cases). Generally, cyclin D1 is expressed. Cyclin D1-negative<unk>  can be diagnosed by detecting the SOX11 marker. The workup for<unk>  is similar to the workup for many indolent<unk> s and certain aggressive<unk> s.<unk>  is a systemic disease with frequent involvement of the bone marrow and gastrointestinal tract (generally showing polyposis in the lining). There is also a not-uncommon leukemic phase, marked by its presence in the blood. For this reason, both the peripheral blood and bone marrow are evaluated for the presence of malignant cells. Chest, abdominal, and pelvic CT scans are routinely performed. Since<unk>  may present a<unk> tous polyposis coli and colon involvement is common, colonoscopy is considered a routine part of the evaluation. Upper endoscopy and neck CT scan may be helpful in selected cases. In some patients with the blastic variant, lumbar puncture is done to evaluate the spinal fluid for involvement. CT scan PET scan
Mantle cell lymphoma
Mature T-cell lymphoma
Mixed-cell lymphoma
Diffuse large B-cell lymphoma
Anaplastic large-cell lymphoma
Aggressive lymphoma
Marginal zone B-cell lymphoma
Nodal marginal zone B cell lymphoma