<unk>  is inherited in an autosomal recessive pattern, which means two copies of the gene in each cell are altered. Most often, parents of affected individuals each carry one copy of the altered gene, but do not show any signs or symptoms. Mutations in the ALS2 gene, found on Chromosome 2, are responsible for causing<unk> . The ALS2 gene provides instructions for making a protein called alsin. Alsin is abundant in motor neurons, but its function is not fully understood. Mutations in the ALS2 gene in this disorder disrupt the instructions for producing alsin. As a result, alsin is unstable and decays rapidly, or it is disabled and cannot function properly. It is currently unknown how the loss of functional alsin protein causes the death of motor neurons and the symptoms of<unk> .
Juvenile primary lateral sclerosis
Primary lateral sclerosis
Amyotrophic lateral sclerosis
Tumefactive multiple sclerosis
CMV polyradiculomyelopathy
Paraneoplastic cerebellar degeneration
Viliuisk encephalomyelitis
Bickerstaff brainstem encephalitis