The diagnosis of<unk>  is made indirectly with immunochemical methods which detect the elevation of biomarkers such as D-Dimer (cross-linked fibrin degradation products), fibrinogen split products (FSP), complexes of plasmin and alpha-2-antiplasmin (PAP). However, the sensitivity and specificity of these methods is limited because elevation of these biomarkers can also occur induced in other clinical conditions. The classical coagulation tests such as PT (prothrombin time), aPTT (activated partial thromboplastin time) or thrombin time are not very sensitive for<unk> , and influenced by numerous other variables. The euglobulin lysis time test is very time consuming and complex. Viscoelastic methods in whole blood, especially thromboelastometry (TEM) when performed with special reagents detect<unk>  very sensitively in a functional approach. The APTEM test, a tissue factor activated, heparin insensitive test performed in the presence of aprotinin (fibrinolysis inhibitor, confirms<unk>  by comparing the TEM result of this assay with the EXTEM test (same activator, but without aprotinin). A normalization or improvement of the TEMogram in APTEM versus EXTEM confirms<unk> . This in vitro approach can predict to a certain level if normal clot formation can be restored by use of an antifibrinolytic drug.
Hyperfibrinolysis
Procoagulant platelets
Warfarin resistance
Venom-induced consumption coagulopathy
Primary fibrinogenolysis
Thrombocythemia
Vitamin K reaction
Intravascular hemolysis