<unk>  (GME) is an inflammatory disease of the central nervous system (CNS) of dogs and, rarely, cats. It is a form of<unk> . GME is likely second only to encephalitis caused by canine distemper virus as the most common cause of inflammatory disease of the canine CNS. The disease is more common in female dogs of young and middle age. It has a rapid onset. The lesions of GME exist mainly in the white matter of the cerebrum, brainstem, cerebellum, and spinal cord. The cause is only known to be noninfectious and is considered at this time to be idiopathic. Because lesions resemble those seen in allergic<unk> , GME is thought to have an immune-mediated cause, but it is also thought that the disease may be based on an abnormal response to an infectious agent. One study searched for viral DNA from canine herpesvirus, canine adenovirus, and canine parvovirus in brain tissue from dogs with GME, necrotizing<unk> , and necrotizing leukoencephalitis (see below for the latter two conditions), but failed to find any.
Granulomatous meningoencephalitis
Fungal meningitis
Drug-induced aseptic meningitis
Herpesviral meningitis
Tuberculous meningitis
Aseptic meningitis
Herpesviral encephalitis
Amoebic brain abscess