The combination of<unk>  and tazobactam, commonly branded as Zosyn, improves their overall bactericidal activity as amino-benzylpenicillins and ureidopencillins work synergistically with β-lactamase inhibitors. Concurrent use or unregulated dosages of<unk>  results in increasing levels of<unk>  within the body, prolonging neuromuscular transmission blockages created by non-depolarizing muscle relaxants, and disruptions in urine tests for glucose. Some compounds that may interfere with the bactericidal activity of<unk>  include chloramphenicol, macrolides, and sulfonamides. Following two studies conducted in 1986 and 2006,<unk>  was found to inhibit the removal of methotrexate in animal kidneys. Furthermore, in the presence of<unk> -tazobactam, the decay time for methotrexate triples in comparison to the normal half-life, leaving the patient exposed to cytotoxic effects produced by the chemical agent. While penicillin antibiotics generally work synergistically with aminoglycosides by enhancing their penetration of bacterial membranes, they can also work adversely by inactivating them. A reformulation of ethylenediaminetetraacetic acid and<unk> -tazobactam has produced results showing an increase in their affinity with amikacin and gentamicin in vitro, enabling the process of simultaneous Y-site infusion to occur. However, tobramycin was found to be incompatible as a combination through Y-site infusion.
Piperacillin
Cloxacillin
Resistin
Carbenicillin
Cefazolin
Ampicillin
Dicloxacillin
Vancomycin