A collagen- and thrombin-activated <unk>  is a platelet function disorder that is due to a reduced ability to generate procoagulant platelets. It is associated with a clinically relevant bleeding phenotype. During physiological platelet activation, a fraction of platelets expresses phosphatidylserine on their surface and become highly efficient in sustaining thrombin generation. These so-called<unk>  platelets, can be generated by dual-agonist stimulation with collagen and thrombin in a laboratory setting.<unk> s should be distinguished from Scott syndrome, a rare bleeding disorder in which patients have impaired phospholipid scrambling and do not express negatively charged phospholipids on their surface even after treatment with calcium ionophores.
COAT platelet defect
Harris platelet syndrome
Factor VII deficiency
Factor XII deficiency
Activated protein C resistance
Protein C deficiency
Quebec platelet disorder
Factor I deficiency