<unk>  is a structural mimic of the anion pyrophosphate that selectively inhibits the pyrophosphate binding site on viral DNA polymerases at concentrations that do not affect human DNA polymerases. In individuals treated with the DNA polymerase inhibitors acyclovir or ganciclovir, HSV or CMV particles can develop mutant protein kinases (thymidine kinase or UL97 protein kinase, respectively) that make them resistant to these antiviral drugs. However, unlike acyclovir and ganciclovir,<unk>  is not activated by viral protein kinases, making it useful in acyclovir- or ganciclovir-resistant HSV and CMV infections. However, acyclovir- or ganciclovir-resistant mutants with alterations in viral DNA polymerase may also be resistant to<unk> .
Foscarnet
Remdesivir
Letermovir
Coronavir
Balapiravir
Entecavir
Fostemsavir
Lamivudine