Most individuals with this condition do not survive beyond childhood. Individuals with MDS usually die in infancy and therefore do not live to the age where they can reproduce and transmit MDS to their offspring. Due to more accurate diagnosis by MRI and improved management of symptoms with medical treatments including gastrostomy(feeding tubes), suction machines, seizure medications, tracheostomy, and management of secretions, more children are surviving into adulthood and have a better quality of life. Development of skills and core strength may be improved with physical therapy, but improvement is limited by the severity of the condition. Some children may be able to sit up, crawl, or say a few basic words, but most are severely developmentally delayed and remain at the level of infants for their lifetime. At all ages the most common cause of death is pneumonia, often after multiple cases have weakened the respiratory function.
Miller–Dieker syndrome
Silver–Russell syndrome
Smith–Magenis syndrome
Marshall–Smith syndrome
Laurence–Moon syndrome
Wiedemann–Steiner syndrome
Wilson–Turner syndrome
Malouf syndrome