Pharmacodynamics<unk>  is a dual antagonist of the orexin OX1 and OX2 receptors. It associates and dissociates from the orexin receptors more rapidly than certain other orexin receptor antagonists, such as suvorexant, and this may cause it to have a shorter duration of action. Pharmacokinetics The bioavailability of<unk>  is good and is at least 87%. The time to peak levels of<unk>  is 1 to 3 hours. A high-fat and high-calorie meal has been found to delay the time to peak levels by 2 hours. Its plasma protein binding in vitro is 94%.<unk>  is metabolized primarily by CYP3A4 and to a lesser extent by CYP3A5. The "effective" half-life of<unk>  is 17 to 19 hours while its terminal elimination half-life is 55 hours. The medication is excreted in feces (57%) and to a lesser extent urine (29%).
Lemborexant
Maropitant
Biperiden
Seltorexant
Furegrelate
Fenproporex
Bocasan
Pleconaril