Types Type I<unk>  can be detected via blood tests for the presence of a fumarylacetoacetate metabolite, succinylacetone, which is considered a pathognomonic indicator for the disease. Type II<unk>  can be detected via the presence of significantly elevated plasma tyrosine levels, and the diagnosis can be confirmed by detection of a mutation in TAT in cultured fibroblasts. Type III<unk>  can be diagnosed by detection of a mutation in HPD in cultured fibroblasts. Pathophysiology of metabolic disorders of tyrosine, resulting in elevated levels of tyrosine in blood.
Tyrosinemia
Hawkinsinuria
Cystathioninuria
Aspartylglucosaminuria
Argininemia
Alkaptonuria
Orotic aciduria
Urocanic aciduria