The<unk>  (also known as Na+-Cl− cotransporter, NCC or NCCT, or as the thiazide-sensitive Na+-Cl− cotransporter or TSC) is a cotransporter in the kidney which has the function of reabsorbing<unk>  and<unk>  ions from the tubular fluid into the cells of the distal convoluted tubule of the nephron. It is a member of the SLC12 cotransporter family of electroneutral cation-coupled<unk>  cotransporters. In humans, it is encoded by the gene (solute carrier family 12 member 3) located in 16q13. A loss of NCC function causes Gitelman syndrome, an autosomic recessive disease characterized by salt wasting and low blood pressure, hypokalemic metabolic alkalosis, hypomagnesemia and hypocalciuria. Over a hundred different mutations in the NCC gene have been identified.
Sodium-chloride symporter
Sulfate transporter
Thiamine transporter 1
Carboxylate transporter
Band 3 anion transport protein
Norepinephrine transporter
Zinc transporter 8
Phosphorylase kinase, alpha 1