Mutations in the TBX5 gene cause<unk> . The TBX5 gene produces a protein that is critical for the proper development of the heart and upper limbs before birth.<unk>  has an autosomal dominant pattern of inheritance, meaning one abnormal copy of the gene is sufficient to cause disease, which each child has a 50% chance of inheriting from an affected parent. However, in 85 percent of cases, the gene mutation isn't inherited, but a new mutation.
Holt–Oram syndrome
Smith–Magenis syndrome
Marshall–Smith syndrome
Laron syndrome
Hanhart syndrome
Ring chromosome 20 syndrome
Wilson–Turner syndrome
Turner syndrome