<unk>  is typically administrated as an eye drop which keeps its effects regional as compared to systemic effects. The main metabolite of<unk>  is a carboxylic acid metabolite that has minimal systemic effects. The maximum concentration of its main active metabolite is 0.06 ng/ml at Tmax of 15 minutes. The minimal absorption of<unk> , leads to minimal systemic accumulation. The half life of the major metabolite of<unk>  is two hours after ocular administration. Except for the metabolite, the rest of<unk>  is excreted unchanged. Since<unk>  is administrated at a small concentration and at a local site (the eye), it seems to have minimal systemic effects.
Alcaftadine
Loratadine
Rimantadine
Desloratadine
Amantadine
Rupatadine
Quifenadine
Tecovirimat