The majority of currently approved antidepressants act predominantly or exclusively as MRIs, including the selective serotonin reuptake inhibitors (SSRIs), serotonin–norepinephrine reuptake inhibitors (SNRIs), and almost all of the tricyclic antidepressants (TCAs). Many psychostimulants used either in the treatment of or as appetite suppressants in the treatment of obesity also behave as MRIs, although notably amphetamine (and methamphetamine), which do act to some extent as<unk> s, exerts their effects primarily as releasing agents. Additionally, psychostimulants acting as MRIs that affect dopamine such as cocaine and methylphenidate are often abused as recreational drugs. As a result, many of them have become controlled substances, which in turn has resulted in the clandestine synthesis of a vast array of designer drugs for the purpose of bypassing drug laws; a prime example of such is the mixed<unk>  and releasing agent mephedrone.
Monoamine reuptake inhibitor
Glycine reuptake inhibitor
Dopamine reuptake inhibitor
Norepinephrine reuptake inhibitor
Serotonin–dopamine reuptake inhibitor
Serotonin–norepinephrine reuptake inhibitor
Excitatory amino acid reuptake inhibitor
Adenosine reuptake inhibitor