Mitral valve prolapse is a genetically heterogeneous autosomal dominant trait, which can be passed down from one parent to child, who will have a 50% chance to inherit the mutated gene. An association with primary cilia defects has been reported. The mutations were found in the Zinc finger protein DZIP1 gene which regulates ciliogenesis; the same problem was found in mice who also developed MVP with this gene. It was found that primary cilia loss during development results in progressive myxomatous degeneration and profound mitral valve pathology. Myxomatous degeneration of mitral valve is a genetic abnormality mapped to gene Xq28. Other genes associated with MVP are: * 13.q31.3-q32.1 * 16p12.1-p11.2 * Ch16p11.2-p12.1 * 11p15.4 * DCHS1
causes of Mitral insufficiency
causes of Mitral valve stenosis
causes of Cardiac tamponade
causes of Ventricular tachycardia
complications of Left ventricular hypertrophy
causes of Cardiomegaly
risks of Atrial fibrillation
symptom of Mitral valve stenosis