<unk><unk> s act on the voltage-gated sodium channels that conduct electrical impulses and mediate fast depolarization along<unk> s.<unk><unk> s also act on potassium channels, but they block sodium channels more. Lidocaine preferentially binds to the inactivated state of voltage-gated sodium channels, but has also been found to bind potassium channels, G protein-coupled receptors, NMDA receptors, and calcium channels in vitro. The duration of the block is mostly influenced by the amount of time the<unk>  is near the<unk> . Lipid solubility, blood flow in the tissue, and presence of vasoconstrictors with the<unk>  all play a role in this. A higher lipid solubility makes the<unk>  more potent and have a longer duration of action; however, it also increases the toxicity of the drug.
Local anesthetic nerve block
Local anesthesia
Analgesic adjuvant
Electroanalgesia
Nerve block
Neuroleptanalgesic
Neuromuscular blocking agents
Tactile induced analgesia