<unk>  is usually well tolerated, with the most common side effects being, in approximately descending order of frequency: creatine phosphokinase elevation, flatulence, abdominal pain, constipation, diarrhoea, muscle aches or pains, nausea, indigestion, weakness, blurred vision, rash, dizziness and muscle cramps. As with all statin drugs, it can rarely cause myopathy, hepatotoxicity (liver damage), dermatomyositis or rhabdomyolysis. This can be life-threatening if not recognised and treated in time, so any unexplained muscle pain or weakness whilst on<unk>  should be promptly mentioned to the prescribing doctor. Other uncommon side effects that should be promptly mentioned to either the prescribing doctor or an emergency medical service include: These less serious side effects should still be reported if they persist or increase in severity: Contraindications Contraindications, conditions that warrant withholding treatment with<unk> , include pregnancy, breast feeding, and liver disease.<unk>  is contraindicated during pregnancy (Pregnancy Category X); it may cause birth defects such as skeletal deformities or learning disabilities. Owing to its potential to disrupt infant lipid metabolism,<unk>  should not be taken while breastfeeding. Patients with liver disease should not take<unk> . Interactions As with atorvastatin, simvastatin, and other statin drugs metabolized via CYP3A4, drinking grapefruit juice during<unk>  therapy may increase the risk of side effects. Components of grapefruit juice, the flavonoid naringin, or the furanocoumarin bergamottin inhibit CYP3A4 in vitro, and may account for the in vivo effect of grapefruit juice concentrate decreasing the metabolic clearance of<unk> , and increasing its plasma concentrations.
Lovastatin
Ezetimibe
Clofibrate
Fenofibrate
Simvastatin
Fluvastatin
Atorvastatin
Pravastatin