As<unk>  is mainly metabolized by the liver enzyme CYP3A4, inhibitors of this enzyme can increase its concentrations in the body and thus its potential for side effects. Examples include itraconazole (which increased<unk>  exposure 2.9-fold in a study), ketoconazole, clarithromycin and grapefruit juice. Conversely, CYP3A4 inducers such as rifampicin and St John's wort decrease<unk>  concentrations; with rifampicin, the reduction was 83% in a study. Strong inhibitors of the pump P-glycoprotein such as ciclosporin may increase<unk>  concentrations in the blood plasma.
Naldemedine
Avacopan
Clopenthixol
Levomepromazine
Acetomepregenol
Dihydroergotamine
Alosetron
Ephedrine