. Vehicle accidents are the most frequent cause of<unk> ; it can also occur as the result of child abuse such as in shaken baby syndrome. Immediate disconnection of axons could be observed in severe brain<unk> , but the major damage of<unk>  is delayed secondary axon disconnections slowly developed over an extended time course. Tracts of axons, which appear white due to myelination, are referred to as white matter. Lesions in both grey and white matters are found in postmortem brains in CT and MRI exams. Besides mechanical breaking of the axonal cytoskeleton,<unk>  pathology also includes secondary physiological changes such as interrupted axonal transport, progressive swellings and degeneration. Recent studies have linked these changes to twisting and misalignment of broken axon microtubules, as well as tau protein and amyloid precursor protein (APP) deposition.
Diffuse axonal injury
Wallerian degeneration
Central chromatolysis
Synaptopathy
Hemorrhagic infarct
Acute motor axonal neuropathy
Posterior circulation infarct
Subacute combined degeneration of spinal cord