Application of<unk>  leads to the depression of neuronal activity. The depression causes the nervous system to become hypersensitive, producing restlessness and shaking, leading to minor to severe convulsions. Studies on animals have shown the use of<unk>  led to the increase of dopamine and serotonin levels in the brain. Other issues may occur because of varying individual tolerance to<unk>  dosage. Nervousness and dizziness can arise from the excitation of the central nervous system, which may lead to respiratory failure if overdosed.<unk>  may also induce weakening of the myocardium leading to cardiac arrest.<unk>  can also cause allergic reactions causing individuals to have problems with breathing, rashes, and swelling. Allergic reactions to<unk>  are usually not in response to<unk>  itself, but to its metabolite PABA. Allergic reactions are in fact quite rare, estimated to have an incidence of 1 per 500,000 injections. About one in 3000 white North Americans is homozygous (i.e. has two copies of the abnormal gene) for the most common atypical form of the enzyme pseudocholinesterase, and do not hydrolyze ester anesthetics such as<unk> . This results in a prolonged period of high levels of the anesthetic in the blood and increased toxicity. However, certain populations in the world such as the Vysya community in India commonly have a deficiency of this enzyme.
Procaine
Articaine
Tetracaine
Bupivacaine
Ibogaine
Iontocaine
Levobupivacaine
Oxybuprocaine