In neurophysiology,<unk>  <unk>  is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or<unk> er following a<unk>  patterned stimulus.<unk>  occurs in many areas of the CNS with varying mechanisms depending upon brain region and developmental progress. As the opposing process to<unk> -term potentiation (LTP),<unk>  is one of several processes that serves to selectively weaken specific synapses in order to make constructive use of synaptic strengthening caused by LTP. This is necessary because, if allowed to continue increasing in strength, synapses would ultimately reach a ceiling level of efficiency, which would inhibit the encoding of new information. Both<unk>  and LTP are forms of synaptic plasticity.
Long-term depression
Treatment-resistant depression
Recurrent brief depression
Terminal illness
Double depression
At risk mental state
Outline of bipolar disorder
Risk factors of schizophrenia