<unk>  (factor I) is a glycoprotein complex, produced in the liver, that circulates in the blood of all vertebrates. During tissue and vascular injury, it is converted enzymatically by thrombin to<unk> rin and then to a<unk> rin-based blood clot.<unk> rin clots function primarily to occlude blood vessels to stop bleeding.<unk> rin also binds and reduces the activity of thrombin. This activity, sometimes referred to as antithrombin I, limits clotting.<unk> rin also mediates blood platelet and endothelial cell spreading, tissue<unk> roblast proliferation, capillary tube formation, and angiogenesis and thereby promotes revascularization and wound healing. Reduced and/or dysfunctional<unk> s occur in various congenital and acquired human<unk> -related disorders. These disorders represent a group of rare conditions in which individuals may present with severe episodes of pathological bleeding and thrombosis; these conditions are treated by supplementing blood<unk>  levels and inhibiting blood clotting, respectively. These disorders may also be the cause of certain liver and kidney diseases.<unk>  is a "positive" acute-phase protein, i.e. its blood levels rise in response to systemic inflammation, tissue injury, and certain other events. It is also elevated in various cancers. Elevated levels of<unk>  in inflammation as well as cancer and other conditions have been suggested to be the cause of thrombosis and vascular injury that accompanies these conditions.
Fibrinogen
Factor VIII
Factor VIII 
Β-Thromboglobulin
Von Willebrand factor
Platelet-activating factor
Factor IX
Thrombin