<unk>  is a genetic disorder affecting the midbrain and cerebellum of the central nervous system. It is caused by mutations in the gene for glial fibrillary acidic protein (GFAP) that maps to chromosome 17q21. It is inherited in an autosomal dominant manner, such that the child of a parent with the<unk>  has a 50% chance of inheriting the condition, if the parent is heterozygotic. However, most cases arise de novo as the result of sporadic mutations.<unk>  belongs to leukodystrophies, a group of<unk> s that affect the growth or development of the myelin sheath. The destruction of white matter in the brain is accompanied by the formation of fibrous, eosinophilic deposits known as Rosenthal fibers. Rosenthal fibers appear not to be present in healthy people, but occur in specific<unk> s, like some forms of cancer, Alzheimer’s, Parkinson’s, Huntington’s, and ALS. The Rosenthal fibers found in<unk>  do not share the distribution or concentration of other<unk> s and disorders.
Alexander disease
Leber's hereditary optic neuropathy
Kjer's optic neuropathy
Corneal-cerebellar syndrome
Graves' ophthalmopathy
Neuromyelitis optica spectrum disorder
Ocular myasthenia
Bosch-Boonstra-Schaaf optic atrophy syndrome