<unk>  (CAF) is a rare, benign tumor of superficial soft tissues that was first described by M. R. Nucci et al. in 1997. These tumors occur predominantly in the distal parts of the female and male reproductive systems, i.e. in the vulva-vaginal and inguinal-scrotal areas, respectively, or, less commonly, in various other superficial soft tissue areas throughout the body. CAF tumors develop exclusively in adults who typically are more than 30 years old. CAF tumors are composed of bland mesenchymal spindle-shaped cells in an edematous (i.e. abnormally swollen with fluid) to fiber-laded connective tissue background. Mesenchymal cells are cells in the cell lineage that includes fibroblasts, adipocytes (i.e. fat cells), macrophages, mast cells, leucocytes, and the precursor cells which mature into these cell types. In 2020, the World Health Organization classified<unk>  tumors in the category of benign fibroblastic and myofibroblastic tumors. CAF tumors rarely recur after surgical removal and do not metastasize to distant tissues. Accordingly, surgical resection is the commonly performed and current standard for treating these tumors.
Cellular angiofibroma
Angiofibroma
Fibroma
Collagenous fibroma
Juvenile hyaline fibromatosis
Littoral cell angioma
Sclerotic fibroma
Angiokeratoma