<unk>  <unk>  is a condition that results in the<unk>  inability of the cell to respond to androgens. It is an X linked recessive condition. The<unk>  unresponsiveness of the cell to the presence of androgenic hormones impairs the masculinization of male genitalia in the developing fetus, as well as the development of male secondary sexual characteristics at puberty, but does not significantly impair female genital or sexual development. As such, the insensitivity to androgens is clinically significant only when it occurs in individuals with a Y chromosome (or more specifically, an SRY gene). Clinical features include ambiguous genitalia at birth and primary amenhorrhoea with clitoromegaly with inguinal masses. Mullerian structures are not present in the individual.<unk>  is one of three types of androgen insensitivity syndrome, which is divided into three categories that are differentiated by the degree of genital masculinization: complete androgen insensitivity syndrome (CAIS) is indicated when the external genitalia is that of a typical female, mild androgen insensitivity syndrome (MAIS) is indicated when the external genitalia is that of a typical male, and<unk>  <unk>  is indicated when the external genitalia is<unk> ly, but not fully masculinized. Androgen insensitivity syndrome is the largest single entity that leads to 46,XY undermasculinization. There are differing opinions on whether treatment is necessary. Treatment may include irreversible and far reaching surgical operations such as gonadectomy, as well as hormone replacement therapy, or vaginoplasty if the patient has desire to engage in penetrative sex.
Partial androgen insensitivity syndrome
Mild androgen insensitivity syndrome
Complete androgen insensitivity syndrome
Androgen insensitivity syndrome
Estrogen insensitivity syndrome
Aromatase excess syndrome
Gonadotropin-releasing hormone insensitivity
Kallmann syndrome