+<unk>  Site Ki (nM) Species Ref ≥34,527≥26,471 HumanRat >100,000100,000 HumanRat 5-HT1A 636–1,371 Rat 5-HT2A 159–211 Rat 5-HT2C α1 1731,000 HumanRat α2 1,9151,000 HumanRat β >100,000 Rat H1 11 Guinea pig >100,000 Rat Values are Ki (nM). The smaller the value, the more strongly the drug binds to the site.<unk>  shows significant affinity for the serotonin 5-HT1A and 5-HT2A receptors, the α1-adrenergic receptor, and the histamine H1 receptor. It shows negligible affinity for the serotonin and norepinephrine transporters and the muscarinic acetylcholine receptors. + Comparison of binding profiles of<unk>  and related compounds Compound 5-HT1A 5-HT2A α1 α2 β H1 Hydroxynefazodone 56–589 7.2–34 165–1,203 376–1,053 8.0–145 63–2,490 >1,000 28 11,357 16–411 110–433 127–432 490–4,360 97–763 112–371 4,890 449 4,702 Nefazodone 52–1,030 7.1–32 181–549 200–713 5.5–144 84–41,700 >100,000 30 4,569 Trazodone 42–288 11–20 115–690 ≥20,887 12–23 106–1,070 47,100 29 12,188<unk>  636–1,371 159–211 ≥26,471 >100,000 ≥173 ≥1,915 >100,000 11 >100,000 Values are Ki (nM). The smaller the value, the more strongly the drug binds to the site.
Triazoledione
Mesterolone
Segesterone acetate
Sakacin
Metenolone
Metenolone enanthate
Proglumetacin
Trenbolone enanthate