ENaC/DEG superfamily ASIC There are six known ASIC subunits, ASIC1a, ASIC1b, ASIC2a, ASIC2b, ASIC3, and ASIC4, which have two transmembrane domains, extracellular and intracellular loops, and C and N termini. These ASIC subunits likely form tetramers with varying kinetics, pH sensitivity, tissue distribution, and pharmacological properties. TRP superfamily There are seven subfamilies within the TRP superfamily: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin), TRPA (ankyrin), and TRPN (NOMPC-like). TRP proteins typically consist of six transmembrane domains, S1, S2, S3, S4, S5, and S6, with a pore between S5 and S6. These contain intracellular N and C termini, which form tetramers and vary in length and domain. Within the<unk> there are ankyrins, which are structural proteins that mediate protein-protein interactions, and are thought to contribute to the tether model of stretch-activated<unk> opening. NOMPC, identified in D. melanogaster mechanotransduction and a member of the TRPN subfamily, contains a relatively high number of ankyrins. K1-selective superfamily K2P<unk>  consist of six subfamilies and contain four transmembrane domains, which form two pores each between domains 1–2 and 3–4. K2P<unk>  also contain a short N terminal domain and a C terminal which varies in length. There is also a large extracellular linker region between domain 1 and the first pore formed between domains 1–2.
Mechanosensitive channels
Cyclic nucleotide–gated ion channel
Glutamate transporter
SK channel
Norepinephrine transporter
Voltage-gated ion channel
Neurotransmitter transporter
G protein-gated ion channel