<unk>  has an oral bioavailability of approximately 25% and reaches peak blood concentrations around 2-4 hours after ingestion. The estimated elimination half-life is determined to be approximately 6 hours, volume distribution of 17 litres, and a protein binding of 95% is seen. The elderly may see increases in half life of the drug by up to 35% but dosing adjustment will not typically be warranted, however the drug should be used with caution in severe liver or kidney impairment. Majority of the drug is eliminated through the feces (83%) while only a small portion is eliminated in the urine (13%). Most of the drug excreted is unchanged, only small portion of the drug is metabolized to its inactive form 4-hydroxyvaleryl<unk> , the enzyme suspected to be responsible for this is the liver enzyme CYP2C9. Hydrochlorothiazide has an oral bioavailability of 70% and reaches peak concentration around 1.5-2 hours following ingestion. The half-life is quite variable for this drug and can range from 5-15 hours. This drug is not metabolized and is mostly excreted unchanged in the urine (60-70%). Protein binding ranges between 40-70% and volume of distribution varies from 4-8L/kg.
Valsartan/hydrochlorothiazide
Losartan/hydrochlorothiazide
Olmesartan/hydrochlorothiazide
Atenolol/chlorthalidone
Enalapril/hydrochlorothiazide
Telmisartan/hydrochlorothiazide
Lisinopril/hydrochlorothiazide
Hydrochlorothiazide/triamterene