The morphology of<unk> s results in a very large surface-to-volume ratio. That is, the<unk>  has a very large surface area compared to the overall cell volume. In vivo – primate The most common division of<unk> s is "myeloid" vs. "plasmacytoid<unk> " (lymphoid): Name Description Secretion Toll-like receptors Conventional<unk>  (previously called Myeloid<unk>  (cDC or mDC) Most similar to monocytes. mDC are made up of at least two subsets:(1) the more common mDC-1, which is a major stimulator of T cells(2) the extremely rare mDC-2, which may have a function in fighting wound infection Interleukin 12 (IL-12), Interleukin 6 (IL-6), TNF, chemokines TLR 2, TLR 4 Plasmacytoid<unk>  (pDC) Look like plasma cells, but have certain characteristics similar to myeloid<unk> s. Can produce high amounts of interferon-α and were previously called interferon-producing cells. TLR 7, TLR 9 The markers BDCA-2, BDCA-3, and BDCA-4 can be used to discriminate among the types. Histologic comparison of cell types in a germinal center, including follicular<unk> s, H&E stain:- Centrocytes are small to medium size with angulated, elongated, cleaved, or twisted nuclei.- Centroblasts are larger cells containing vesicular nuclei with one to three basophilic nucleoli apposing the nuclear membrane.- Follicular<unk> s have round nuclei, centrally located nucleoli, bland and dispersed chromatin, and flattening of adjacent nuclear membrane. Lymphoid and myeloid<unk> s evolve from lymphoid and myeloid precursors, respectively, and thus are of hematopoietic origin. By contrast, follicular<unk> s (FDC) are probably of mesenchymal rather than hematopoietic origin and do not express MHC class II, but are so named because they are located in lymphoid follicles and have long<unk> " processes. In blood The blood<unk> s are typically identified and enumerated in flow cytometry. Three types of<unk> s have been defined in human blood: the CD1c+ myeloid<unk> s, the CD141+ myeloid<unk> s and the CD303+ plasmacytoid<unk> s. This represents the nomenclature proposed by the nomenclature committee of the International Union of Immunological Societies.<unk> s that circulate in blood do not have all the typical features of their counterparts in tissue, i.e. they are less mature and have no dendrites. Still, they can perform complex functions including chemokine-production (in CD1c+ myeloid<unk> s), cross-presentation (in CD141+ myeloid<unk> s), and IFNalpha production (in CD303+ plasmacytoid<unk> s). In vitro In some respects,<unk> s cultured in vitro do not show the same behaviour or capability as<unk> s isolated ex vivo. Nonetheless, they are often used for research as they are still much more readily available than genuine<unk> s. * Mo-DC or MDDC refers to cells matured from monocytes. * HP-DC refers to cells derived from hematopoietic progenitor cells.
Dendritic cell
T cell
Reactive lymphocyte
Mast cell
Prolymphocyte
Monocyte
Respirocyte
Natural killer cell