<unk> is well-tolerated and produces relatively few adverse effects. Breast tenderness may sometimes occur as a side effect of<unk>  Local reactions with vaginal<unk> such as discomfort (irritation, burning, itching) and discharge may occur.<unk> may produce endometrial hyperplasia similarly to estradiol and other estrogens, and hence should be combined with a progestogen in women with intact uteruses to prevent this risk. However, it appears that typical clinical dosages of vaginal<unk> are not associated with an important risk of endometrial proliferation or hyperplasia. As such, combination with a progestogen may not be needed in the case of vaginal<unk>  Some studies suggest that this may also be true for oral<unk>  However, dosage and frequency of administration, as well as meal consumption, may be determining factors as to whether or not<unk> produces endometrial proliferation.
Estriol 
2-Hydroxyestradiol
Estradiol acetate
Estrogen 
Estrogen
11-Ketoprogesterone
Estradiol 
Estradiol