<unk> , especially in carcinomas, usually precedes spread to the lymph nodes that drain the tissue in which the tumour arose. Conversely, cancers with lymph node spread (known as a lymph node metastases), usually have<unk> . Lymph node metastases usually precede secondary tumours, i.e. distant metastases. The absence of<unk>  in the context of proven lymph node metastasis is usually thought to be due to sampling error.
Lymphovascular invasion
Perineural invasion
Tumor budding
Field cancerization
Nuclear atypia
Positive axillary lymph node
Micrometastasis
Colonial morphology