<unk>  affects the blood, development, and brain; symptoms vary based on the specific genes deleted on chromosome<unk> . Because it is so rare, it is difficult to determine the "core" symptoms of the disease. People with<unk> -16 have alpha-thalassemia, a blood disorder where there is less normal hemoglobin in the blood than there should be, and the red blood cells are smaller than they should be (microcytic anemia). Affected children have various characteristic physical features, including clubfoot, "locked" little fingers, microcephaly (small head), hypertelorism (widely spaced eyes), broad, prominent nose bridge, downward-slanted palpebral fissures, small ears, retrognathia, and short neck. Children with<unk>  also have mild to moderate intellectual disabilities, developmental delays/growth delays, and speech delays. Some children with<unk> -16 have seizures, cryptorchidism (undescended testes), or hypospadias.
ATR-16 syndrome
ATR-X syndrome
MEDNIK syndrome
ZTTK syndrome
Treacher Collins syndrome
LIG4 syndrome
CAMFAK syndrome
Smith Martin Dodd syndrome