<unk>  <unk>  is a rare genetic disorder that affects both bones and skin. Other names are idiopathic hypertrophic osteoarthropathy or Touraine-Solente-Golé syndrome. It is mainly characterized by pachyderma (thickening of the skin), periostosis (excessive bone formation) and finger clubbing (swelling of tissue with loss of normal angle between nail and nail bed). This disease affects relatively more men than women. After onset, the disease stabilizes after about 5–20 years. Life of<unk>  patients can be severely impaired. Currently, symptomatic treatments are NSAIDs and steroids or surgical procedures. In 1868,<unk>  was first described by Friedreich as 'excessive growth of bone of the entire skeleton'. Touraine, Solente and Golé described<unk>  as the primary form of bone disease hypertrophic osteoarthropathy in 1935 and distinguished its three known forms.
Pachydermoperiostosis
Acromegaly
Craniosynostosis
Melorheostosis
Buccal exostosis
Subungual exostosis
Achondroplasia
Pseudoachondroplasia