All statins act by inhibiting 3-hydroxy-3-methylglutaryl (HMG) coenzyme A reductase. HMG-CoA reductase, the rate-limiting enzyme of the HMG-CoA reductase pathway, the metabolic pathway responsible for the endogenous production of cholesterol. Statins are more effective than other lipid-regulating drugs at lowering LDL-cholesterol concentration, but they are less effective than the fibrates in reducing triglyceride concentration. However, statins reduce cardiovascular disease events and total mortality irrespective of the initial cholesterol concentration. This is a major piece of evidence that statins work in another way than the lowering of cholesterol (called pleiotropic effects). The drug is in the form of an inactive lactone that is hydrolyzed after ingestion to produce the active agent. It is a white, nonhygroscopic, crystalline powder that is practically insoluble in water, and freely soluble in chloroform, methanol, and ethanol.<unk>  is an effective serum lipid-lowering drug that can decrease low density lipoprotein (LDL) levels by up to 50%.<unk>  had been shown to interact with lipid-lowering transcription factor PPAR-alpha and that interaction might control the neurotrophic action of the drug.
Simvastatin
Ezetimibe
Fluvastatin
Lovastatin
Clofibrate
Atorvastatin
Fenofibrate
Pravastatin