The cause of<unk>  is unknown. Fewer than 1% of those with<unk>  have a family member with the same disorder. A variant in the gene for tau protein called the H1 haplotype, located on chromosome 17 ( rs1800547), has been linked to<unk> . Nearly all people with<unk>  received a copy of that variant from each parent, but this is true of about two-thirds of the general population. Therefore, the H1 haplotype appears to be necessary but not sufficient to cause<unk> . Other genes, as well as environmental toxins, are being investigated as other possible contributors to the cause of<unk> . Additionally, the H2 haplotype, combined with vascular dysfunction, seems to be a factor of vascular<unk> . Besides tauopathy, mitochondrial dysfunction seems to be a factor involved in<unk> . Especially, mitochondrial complex I inhibitors (such as acetogenins and quinolines contained in Annonaceae, as well as rotenoids) are implicated in<unk> -like brain injuries.
Progressive supranuclear palsy
Frontotemporal dementia and parkinsonism linked to chromosome 17
Multiple system atrophy
Corticobasal degeneration
Parkinson-plus syndrome
Parkinson's disease
Benign hereditary chorea
Alzheimer's disease