MPFD is diagnosed based on histological examination of the chorionic villi of the placenta. This diagnostic process is difficult, as there is great variety in appearance, and an overlap in signs with maternal floor infarction.
Massive perivillous fibrin deposition
Collagenous spherulosis
Nodular vasculitis
Cerebroretinal microangiopathy with calcifications and cysts
Reactive perforating collagenosis
Platelet-rich fibrin matrix
Granulovacuolar degeneration
Palisaded neutrophilic and granulomatous dermatitis