<unk>  is named for its clinical similarity to<unk><unk> , in which immune complexes are deposited in the skin, joints, and other organs. True<unk><unk> , a type III hypersensitivity<unk> , results in fever, lymphadenopathy, arthralgias, cutaneous eruptions, gastrointestinal disturbances, proteinuria, and significant decreases in<unk>  complement levels; it was originally described after patients were infused with equine immunoglobulins. In contrast,<unk> s are specific drug<unk> s that are not associated with circulating immune complexes. Although the exact pathogenesis is poorly understood,<unk> s are thought to originate from an abnormal inflammatory<unk>  that occurs in response to defective metabolism of drug byproducts generated during pharmacologic therapy; the metabolic flaw could be a maternally-inherited trait. In vivo hepatic drug biotransformation studies have shown greater lymphocyte killing in subjects with a known history of<unk> s than in control subjects.
Serum sickness-like reaction
Papular purpuric gloves and socks syndrome
Acute cutaneous lupus erythematosus
Disseminated disease
Levamisole induced necrosis syndrome
Relapsing fever
Adult-onset Still's disease
Tick-borne lymphadenopathy