Corneal clouding in a 30-year-old male with MPS VI.<unk>  and other MPS disorders may also present with corneal clouding Patients with<unk>  appear healthy at birth. Types A and B have similar presentations, but Type B generally has milder symptoms. The age of onset is usually between 1 and 3 years of age.<unk>  causes progressive changes to the skeleton of the ribs and chest, which may lead to neurological complications such as nerve compression. Patients may also have hearing loss and clouded corneas. Intelligence is usually normal unless a patient suffers from untreated hydrocephalus. Physical growth slows and often stops around age 8. Skeletal abnormalities include a bell-shaped chest, a flattening or curvature of the spine, shortened long bones, and dysplasia of the hips, knees, ankles, and wrists. The bones that stabilize the connection between the head and neck can be malformed (odontoid hypoplasia); in these cases, a surgical procedure called spinal cervical bone fusion can be lifesaving. Restricted breathing, joint stiffness, and heart disease are also common. Children with the more severe form of MPS IV may not live beyond their twenties or thirties.
Morquio syndrome
Eiken syndrome
Hapnes Boman Skeie syndrome
Zieve's syndrome
Galloway Mowat syndrome
Schimmelpenning syndrome
Okamoto syndrome
Sanjad-Sakati syndrome