Prolonged treatment may cause a syndrome similar to lupus, which can become fatal if the symptoms are not noticed and drug treatment stopped.<unk>  is within the top three drugs that is known to induce systemic lupus and this adverse drug event is dose dependent yet significant. Very common (>10% frequency) side effects include headache, tachycardia, and palpitations. Common (1–10% frequency) side effects include flushing, hypotension, anginal symptoms, aching or swelling joints, muscle aches, positive tests for atrial natriuretic peptide, stomach upset, diarrhea, nausea and vomiting, and swelling (sodium and water retention).
Hydralazine
Captopril
Chlorothiazide
Cyclothiazide
Furosemide
Metoprolol
Hydrochlorothiazide
Nebivolol