<unk>  (SSC) is a life-threatening illness common in pediatric patients with homozygous sickle cell disease and beta thalassemia. Up to 30% of these children may develop SSC with a mortality rate of up to 15%. This<unk>  occurs when<unk>  vaso-occlusion causes a large percentage of total blood volume to become trapped within the spleen. Clinical signs include severe, rapid drop in hemoglobin leading to hypovolemic shock and death. Pediatric patients with sickle cell disease and beta thalassemia experience multiple<unk>  infarcts, resulting in<unk>  fibrosis and scarring. Over time, this leads to a small, auto infarcted spleen typically by the time patients reach adulthood.<unk>  can only occur in functioning spleens which may be why this<unk>  is rarely seen in adults. However, late adolescent or adult patients in this group who maintain<unk>  function may develop<unk> .
Splenic sequestration crisis
Tumor lysis syndrome
Macrophage activation syndrome
Splenic infarction
Overwhelming post-splenectomy infection
Nephritic syndrome
Multiple organ dysfunction syndrome
Neotenic complex syndrome