There are reported cases of high doses of<unk>  precipitating serotonin syndrome. There are also reports of patients taking multiple SSRIs with<unk>  and precipitating serotonin syndrome.<unk>  appears to be relatively safer than TCAs, MAOIs, and a few of the other second-generation antidepressants in overdose situations, especially when it is the only agent taken. Fatalities are rare, and uneventful recoveries have been reported after ingestion of doses as high as 6,000–9,200mg. In one report, 9 of 294 cases of overdose were fatal, and all nine patients had also taken other central nervous system (CNS) depressants. When<unk>  overdoses occur, clinicians should carefully monitor for low blood pressure, a potentially serious toxic effect. In a report of a fatal<unk>  overdose, torsades de pointes and complete atrioventricular block developed, along with subsequent multiple organ failure, with a<unk>  plasma concentration of 25.4mg/L on admission.
Trazodone
Hydrocodone
Vilazodone
Oxycodone
Nefazodone
Norhydrocodone
Guanfacine
Amitriptyline