<unk>  <unk>  is thyroid hormone deficiency present at birth. If untreated for several months after birth, severe<unk>  can lead to growth failure and permanent intellectual disability. Infants born with<unk>  may show no effects, or may display mild effects that often go unrecognized as a problem. Significant deficiency may cause excessive sleeping, reduced interest in nursing, poor muscle tone, low or hoarse cry, infrequent bowel movements, significant jaundice, and low body temperature. Causes of<unk>  include iodine deficiency and a developmental defect in the thyroid gland, either due to a genetic defect or of unknown cause. Treatment consists of a daily dose of thyroid hormone (thyroxine) by mouth. Because the treatment is simple, effective, and inexpensive, most of the developed world utilizes newborn screening with blood thyroid stimulating hormone (TSH) levels to detect<unk> . Most<unk> ildren with<unk>  correctly treated with thyroxine grow and develop normally in all respects. Approximately 1 in 4000 newborns have a severe deficiency of thyroid function; a greater number have a mild or moderate deficiency.
Congenital hypothyroidism
Congenital iodine deficiency syndrome
Congenital adrenal hyperplasia
Thyroid dysgenesis
Late onset congenital adrenal hyperplasia
Lipoid congenital adrenal hyperplasia
Congenital hyperinsulinism
Isolated growth hormone deficiency