The hyperproliferation of keratinocyte inner root sheath cells in which large aggregates of viral particles can be found suggests that TSPyV actively replicates in these cells. This is thought to underlie the clinical manifestations of TS. However, the precise mechanism is not well characterized. There is limited evidence implicating the large tumor antigen as responsible for inducing cellular proliferation through pathways involving phosphorylated retinoblastoma protein (pRB).
Trichodysplasia spinulosa
Adiposogenital dystrophy
Encephalocraniocutaneous lipomatosis
Pachyonychia congenita
Lipoatrophia annularis
Mandibuloacral dysplasia
Thanatophoric dysplasia
Genu recurvatum