<unk>  (FLAER) is used in a flow cytometric assay to diagnose paroxysmal nocturnal hemoglobinuria (PNH). The assay takes advantage of the action of<unk> , a prototoxin of aerolysin, a virulence factor of the bacterium Aeromonas hydrophila.<unk>  binds to the glycophosphatidylinositol(GPI) anchor in the plasma membrane of cells. Cells affected by PNH lack GPI anchoring proteins, and thus are not bound by<unk> . Of note, the FLAER-based assay is not suitable for evaluation of erythrocytes and platelets in PNH but flow cytometry assays based on CD55, CD59 and others are suitable.
Fluorescein-labeled proaerolysin
Maitotoxin
Penicillin-binding proteins
Delta-Palutoxin
BeKm-1 toxin
Toxic shock syndrome toxin
Lipopolysaccharide binding protein
Hemotoxin