In the followup of 111 patients, most remained stable and event free. However, two patients developed IgM gammopathy 2 lung cancer; one developed cervical cancer and three developed non-Hodgkin's lymphoma. The possibility of developing a clonal proliferation, malignant lymphoma or secondary solid cancer led the authors to conclude not to classify<unk>  as a benign pathology, as has been previously postulated but rather to recommend a careful and continued clinical and biological longterm follow-up.
Persistent polyclonal B-cell lymphocytosis
Chronic active EBV infection
Monoclonal B-cell lymphocytosis
Persistent generalized lymphadenopathy
Lymphoid neoplasms with plasmablastic differentiation
Thymoma-associated multiorgan autoimmunity
Progressive transformation of germinal centres
Immunodeficiency with hyperimmunoglobulin M