Class switch recombination Different genetic defects cause HIgM<unk> , the vast majority are inherited as an X-linked recessive genetic trait and most sufferers are male. IgM is the form of antibody that all B cells produce initially before they undergo class switching due to exposure to a recognized antigen. Healthy B cells efficiently switch to other types of antibodies as needed to attack invading bacteria, viruses, and other pathogens. In people with<unk> s, the B cells keep making IgM antibodies because they can't switch to a different antibody. This results in an overproduction of IgM antibodies and an underproduction of IgA, IgG, and IgE.
Hyper IgM syndrome
Hyper-IgM syndrome type 5
Hyper-IgM syndrome type 2
Hyper-IgM syndrome type 3
Hyper-IgM syndrome type 4
Hyper-IgM syndrome type 1
Anti-IgLON5 disease
Common variable immunodeficiency