PLS is characterized by periodontitis and palmoplantar keratoderma. The severe destruction of periodontium results in loss of most primary teeth by the age of 4 and most permanent teeth by age 14. Hyperkeratosis of palms and soles of feet appear in first few years of life. Destructions of periodontium follows almost immediately after the eruption of last molar tooth. The teeth are involved in roughly the same order in which they erupt.
Papillon–Lefèvre syndrome
Bogart–Bacall syndrome
Michels Caskey syndrome
Bonnet–Dechaume–Blanc syndrome
Jeavons syndrome
Peters-plus syndrome
Bowen–Conradi syndrome
Burnside–Butler syndrome