Apoptosis<unk>  (from Greek κάρυον karyon, "kernel, seed or nucleus", and ῥῆξις rhexis, "bursting") is the destructive fragmentation of the nucleus of a dying cell whereby its chromatin is distributed irregularly throughout the cytoplasm. It is usually preceded by pyknosis and can occur as a result of either programmed cell death (apoptosis), cellular senescence, or necrosis. In apoptosis, the cleavage of DNA is done by Ca2+ and Mg2+ -dependent endonucleases. Image:nuclear changes.Morphological characteristics of pyknosis and other forms of nuclear destruction. File:Apoptotic neutrophil with nuclear fragmentation.Microscopy of an apoptotic neutrophil with nuclear fragmentation (H&E stain)
Karyorrhexis
Onychorrhexis
Synechia 
Hyperpigmentation
Xanthosis
Dyschromia
Acytosiosis
Macrocytosis