Pharmacodynamics The antipsychotic effect of<unk>  is thought to be mediated through antagonist activity at dopamine and serotonin receptors.<unk>  has a high affinity for the D1 and D2 receptors. It also affects the 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 receptors. In addition, its active metabolite, norzotepine, serves as a potent norepinephrine reuptake inhibitor. Macromolecule (Receptor or transporter protein) Ki nM SERT 151 NET 530 DAT 3621 5-HT1A 470.5 5-HT1B 59.5 5-HT1D 119 5-HT1E 700 5-HT2A 2.7 5-HT2C 2.6 5-HT3 472 5-HT5A 29 5-HT6 6 5-HT7 12 α1A 7 α1B 5 α2A 180 α2B 5.35 α2C 106 M1 18 M2 140 M3 73 M4 77 M5 260 D1 71 D2 25 D2S 5.4 D2L 11 D3 6.4 D4 18 D5 248 H1 3.21 H2 500 H4 1977
Zotepine
Dezocine
Midazolam
Remimazolam
Cidoxepin
Mexazolam
Ketazolam
Propizepine