<unk>  is only indicated for dogs at least 16 weeks old, as some very young puppies suffered bone marrow hypoplasia (incomplete development ). It should also not be used in animals with suspected GI obstruction or toxin ingestion. It is not recommended to give<unk>  for more than five consecutive days, as it tends to accumulate in the body due to one of the liver enzymes responsible for its metabolism, CYP2D15, becoming saturated. However, there have been studies where beagles who were given<unk>  for two weeks in a row showed no signs of toxicity. Because<unk>  is metabolized by the liver, caution should be taken when giving it to dogs with liver dysfunction. Caution should also be taken when giving it with other drugs that are also highly protein-bound, such as NSAIDs, anticonvulsants, and some behavior-modifying drugs; such drugs compete with<unk>  for binding to plasma proteins, increasing the concentration of unbound<unk>  in the blood.<unk>  should also not be used with calcium channel antagonists (used to treat high blood pressure) or in animals with heart disease, as it has a slight affinity for calcium and potassium channels.
Maropitant
Lemborexant
Nefopam
Avacopan
Tofisopam
Verapamil
Fenoldopam
Alvimopan