The clinical symptoms are caused by immunological abnormalities (figure 2). These include deficiency in CD27+ B memory cells, overrepresentation of CD10+ transitional B cells, expanded effector (CCR7-) T cells, expanded CD57+ senescent CD8+ T cells, and alterations in serum immunoglobulin concentrations, most with normal to elevated concentrations of IgM and reduced concentrations of IgA. Genetic testing for<unk> /APDS is needed for an accurate diagnosis and appropriate clinical management. A free diagnosis is available via https://www.invitae.com/en/navigateAPDS/
PASLI disease
TRIANGLE disease
BENTA disease
Weber–Christian disease
Marchiafava–Bignami disease
Degos disease
Ruijs-Aalfs syndrome
Brill–Zinsser disease