<unk> s have limitations. Their functionality has been found to be limited when in the presence of the DNA-repair enzyme O-6-methylguanine-DNA methyltransferase (MGMT). Cross-linking of double-stranded DNA by<unk>  agents is inhibited by the cellular DNA-repair mechanism, MGMT. If the MGMT promoter region is methylated, the cells no longer produce MGMT, and are therefore more responsive to<unk>  agents. Methylation of the MGMT promoter in gliomas is a useful predictor of the responsiveness of tumors to<unk>  agents.
Alkylating antineoplastic agent
Immunosuppressive drug
Monoamine-depleting agent
Neuromuscular-blocking drug
Disease-modifying antirheumatic drug
Antihypotensive agent
Endocrine disruptor
Serotonin releasing agent