A meta-analysis study evaluated 5588<unk>  plasma concentrations from 631 subjects over seven clinical studies. Subjects with cancer received multiple doses between 40 mg and 640 mg intravenously over two hours, whilst healthy subjects received either a single or double dose at 320 mg-640 mg. Three compartment model The pharmacokinetics of<unk>  was described by a three-compartment model with first-order elimination where: * Three-compartment model refers to the distribution of the drug. The body is divided into central, peripheral 1, and peripheral 2. Distribution rate of the drug is respectively highest to lowest. * First-order elimination describes the elimination rate of the drug. In first-order kinetics, elimination is proportional to concentration of drug present in the body. For a representative sixty-six year old with a body mass (kg) of eighty-two and a blood<unk>  level of 0.933 mg/dL, the estimated parameter values were: *Clearance (CL) = 2.36 *Central Volume of Distribution (V) = 6.08 *Peripheral Volume of Distribution (V ) = 1.13 *Volume of the Second Peripheral Compartment (V ) = 15.8
Custirsen
Truenat
Epiestriol
Bolesatine
Sesquimustard
Esthiomene
Phenibut
Penmesterol