Patients with<unk>  usually present with signs of hyperandrogenism, rather than of glucocorticoid deficiency, a condition characterized by inadequate cortisol production. Cortisol synthesis impairment is mild but clinically silent.<unk>  patients usually have the same baseline but lower peak cortisol levels comparing to healthy controls. Flatter diurnal cortisol slopes contribute to stress-related dysregulation of central and peripheral circadian mechanisms with negative health outcomes. Due to hyperandrogenism, females may present with symptoms like hirsutism, oligomenorrhea, acne, infertility, and male-pattern baldness. Males are generally asymptomatic, but may present with acne, early balding, chronic prostatitis, chronic pelvic pain syndrome, and very rarely, testicular adrenal rest tumors. While symptoms are usually diagnosed after puberty, children may present with premature adrenarche. The degree of hormonal disorder in patients with<unk>  is relatively mild. However, alterations in the hypothalamic–pituitary–adrenal axis are present even in this mild form of the disease and might contribute to psychiatric vulnerability.
Late onset congenital adrenal hyperplasia
Lipoid congenital adrenal hyperplasia
Congenital adrenal hyperplasia
Primary pigmented nodular adrenocortical disease
Multiple endocrine neoplasia type 1
Multiple endocrine neoplasia type 2
Multiple endocrine neoplasia
Persistent adrenarche syndrome