Bottle containing loxapine capsules, a mid-potency<unk> .<unk> s (formerly known as major tranquilizers, also known as first generation<unk> s) are a class of<unk>  drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia).<unk> s may also be used for the treatment of acute mania, agitation, and other conditions. The first<unk> s to come into medical use were the phenothiazines, namely chlorpromazine which was discovered serendipitously. Another prominent grouping of<unk> s are the butyrophenones, an example of which is haloperidol. The newer, second-generation<unk> s, also known as<unk> s, have largely supplanted the use of<unk> s as first-line agents due to the higher risk of movement disorders in the latter. Both generations of medication tend to block receptors in the brain's dopamine pathways, but<unk> s at the time of marketing were claimed to differ from<unk> s in that they are less likely to cause extrapyramidal symptoms (EPS), which include unsteady Parkinson's disease-type movements, internal restlessness, and other involuntary movements (e.g. tardive dyskinesia, which can persist after stopping the medication). More recent research has demonstrated the side effect profile of these drugs is similar to older drugs, causing the leading medical journal The Lancet to write in its editorial "the time has come to abandon the terms first-generation and second-generation<unk> s, as they do not merit this distinction." While<unk> s are more likely to cause EPS,<unk> s are more likely to cause adverse metabolic effects, such as weight gain and increase the risk for type II diabetes.
Typical antipsychotic
Atypical antidepressant
Tricyclic antidepressant
Tetracyclic antidepressant
Second-generation antidepressant
Atypical antipsychotic
Antipsychotic
Heterocyclic antidepressant