Adverse effects by frequency: ;Very common (>10% frequency): * Appetite loss * Diarrhea * Vomiting * Nausea * Stomatitis * Abdominal pain * Fatigue * Weakness * Hand-foot syndrome * Oedema * Fever * Pain * Headache * Hair loss * Dermatitis * Indigestion * Shortness of breath * Eye irritation * Myelosuppression Notes on adverse effects: Contraindications Contraindications include: * History of hypersensitivity to fluorouracil,<unk>  or any of its excipients * DPD deficiency (see Pharmacogenetics) * Pregnancy and lactation * Severe leucopenia, neutropenia, or thrombocytopenia * Severe hepatic impairment or severe renal impairment * Treatment with sorivudine or its chemically related analogues, such as brivudine Drug interactions Drugs it is known to interact with include: * Sorivudine or its analogues, such as, brivudine. * CYP2C9 substrates, including, warfarin and other coumarin-derivatives anticoagulants * Phenytoin, as it increases the plasma concentrations of phenytoin. * Calcium folinate may enhance the therapeutic effects of<unk>  by means of synergising with its metabolite, 5-FU. It may also induce more severe diarrhoea by means of this synergy. Pharmacogenetics The dihydropyrimidine dehydrogenase (DPD) enzyme is responsible for the detoxifying metabolism of fluoropyrimidines, a class of drugs that includes<unk> , 5-fluorouracil and tegafur. Genetic variations within the DPD gene (DPYD) can lead to reduced or absent DPD activity, and individuals who are heterozygous or homozygous for these variations may have partial or complete DPD deficiency; an estimated 0.2% of individuals have complete DPD deficiency. Those with partial or complete DPD deficiency have a significantly increased risk of severe or even fatal drug toxicities when treated with fluoropyrimidines; examples of toxicities include myelosuppression, neurotoxicity and hand-foot syndrome.
Capecitabine
Oxaliplatin
Gemcitabine
Lipoplatin
Ifosfamide
Paclitaxel
Carboplatin
Topotecan