<unk>  is largely bound to plasma proteins. Benzodiazepines such as<unk>  are lipid-soluble and have a high cerebral uptake. The time for<unk>  to reach peak plasma concentrations following oral administration is about 2 hours (0.5 to 5 hours). The half-life of<unk>  is between 16.5 and 48.3 hours. In young people,<unk>  has a half-life of about 29 hours and a much longer half-life of 40 hours in the elderly. Both low dose (5 mg) and high dose (10 mg) of<unk>  significantly increases growth hormone levels in humans.<unk> 's half-life in the cerebrospinal fluid, 68 hours, indicates that<unk>  is eliminated extremely slowly from the cerebrospinal fluid. Concomitant food intake has no influence on the rate of absorption of<unk>  nor on its bioavailability. Therefore,<unk>  can be taken with or without food.
Nitrazepam
Avacopan
Atogepant
Bupranolol
Beclamide
Clonidine
Brimonidine
Tofisopam