Structural depiction of tetracycline metal chelation, where 'M' is a metal such as those found in<unk> s<unk> s are known to interact with several oral medications, including fluoroquinolone and tetracycline antibiotics, iron, itraconazole, and prednisone. Metal chelation is responsible for some of these interactions (e.g. fluoroquinolones, tetracyclines), leading to decreased absorption of the chelated drug. Some interactions may be due to the pH increase observed in the stomach following<unk>  ingestion, leading to increased absorption of weak acids, and decreased absorption of weak bases.<unk> s also cause an increase in pH of the urine (alkalization), which may cause increased blood concentrations of weak bases, and increased excretion of weak acids. A proposed method to mitigate the effects of stomach acidity and chelation on drug absorption is to space out the administration of<unk> s with interacting medications, however this method has not been well studied for drugs affected by urine alkalization. There are concerns regarding interactions between delayed-release tablets and<unk> s, as<unk> s may increase the stomach pH to a point at which the coating of the delayed-release tablet will dissolve, leading to degradation of the drug if it is pH sensitive.
Antacid
Querulant
Organophosphate
Fruit salt
Keldur
Titratable acid
Alkylphenol
Detergent