A<unk>  is a type of drug which inhibits the enzyme<unk> . It may inhibit both of the functions of the enzyme, 17α-hydroxylase and 17,20-lyase, or may be selective for inhibition of one of these two functions (generally 17,20-lyase). These drugs prevent the conversion of pregnane steroids into androgens like testosterone and therefore are androgen biosynthesis inhibitors and functional antiandrogens. Examples of<unk> s include the older drug ketoconazole and the newer drugs abiraterone acetate, orteronel, galeterone, and seviteronel. The<unk> s that have been marketed, like abiraterone acetate, are used mainly in the treatment of prostate cancer.<unk> s that are not selective for inhibition of 17,20-lyase must be combined with a glucocorticoid such as prednisone in order to avoid adrenal insufficiency and mineralocorticoid excess caused by prevention of cortisol production.
CYP17A1 inhibitor
SGLT2 inhibitor
Steroidogenesis inhibitor
5α-Reductase inhibitor
COX-2 inhibitor
Neurosteroidogenesis inhibitor
Reuptake inhibitor
Antiglucocorticoid