Individuals diagnosed with<unk>  most commonly (>33% of all cases) present with advanced Stage III or IV disease. They are predominately males with a median age of 42 years if they are infected with HIV and 73 years if they are not so infected. Some one-third to one-half of these individuals have a history of Karposi's sarcoma, less commonly of multicentric Castleman disease, and/or rarely of immune deficiency due to organ transplantation, hepatitis complicated by cirrhosis caused by hepatitis B or C viral infection, or of old age.<unk>  occurring in the elderly generally occurs in EBV-negative individuals residing in the Mediterranean region. Individuals with the cavitary form of<unk>  present with symptoms due to<unk> s in the pleural cavity (e.g. shortness of breath), pericardium (e.g. chest pain/discomfort, hypotension, shortness of breath), peritoneal cavity (e.g. abdominal swelling), or, much less often, joints (e.g. swelling), the epidural space (e.g. central nervous system symptoms), or breast implants (e.g. breast swelling/pain/malformation). While most cases of classical<unk>  involve one cavitary site, some individuals present with two or more sites of cavitary involvement. Individuals with extracavitary<unk>  present with lesions in the lung, central nervous system, gastrointestinal tract, and/or lymph nodes. Gastrointestinal track lesions often occur as multiple lymphoid polyps in the large intestine. At diagnosis, more than 50% of individuals afflicted with either cavitary or extracavitary<unk>  have or report a history of B symptoms (i.e. fever, weight loss, night sweat). Laboratory examination in all<unk>  cases often show anemia, low blood levels of platelets, high serum levels of IL6, and high levels of circulating KSHV/HHV8.
Primary effusion lymphoma
AIDS-related lymphoma
Thymoma with immunodeficiency
Mixed-cell lymphoma
Hodgkin lymphoma
Indolent lymphoma
Diffuse infiltrative lymphocytosis syndrome
Gray zone lymphoma