Adverse effects include: * Sedation and sleepiness (often transient) * Dizziness * Disturbed coordination * Confusion * Restlessness * Excitation * Nervousness * Tremor * Irritability * Insomnia * Paresthesias * Neuritis * Convulsions * Euphoria * Hallucinations * Hysteria * Faintness * Allergic manifestation of rash and edema * Diaphoresis * Urticaria * Photosensitivity * Acute labyrinthitis * Diplopia (seeing double) * Vertigo * Tinnitus * Hypotension (low blood pressure) * Palpitation * Extrasystoles * Anaphylactic shock * Hemolytic anemia * Blood dyscrasias such as leukopenia, agranulocytosis and thrombocytopenia * Cholestasis * Hepatic (liver) side effects such as: * Hepatitis * Jaundice * Liver failure * Hepatic function abnormality * Epigastric distress * Anorexia * Nausea * Vomiting * Diarrhea * Anticholinergic side effects such as: * Blurred vision * Constipation * Xerostomia (dry mouth) * Tachycardia (high heart rate) * Urinary retention * Difficulty passing urine * Nasal congestion * Nasal or throat dryness * Urinary frequency * Early menses * Thickening of bronchial secretions * Tightness of chest and wheezing * Fatigue * Chills * Headache * Increased appetite * Weight gain Overdose Gastric decontamination measures such as activated charcoal are sometimes recommended in cases of overdose. The symptoms are usually indicative of CNS depression (or conversely CNS stimulation in some) and excess anticholinergic side effects. The LD50 in mice is 123 mg/kg and 295 mg/kg in rats.
Cyproheptadine
Tripelennamine
Tianeptine
Apomorphine
Alosetron
Tropisetron
Palonosetron
Cilansetron