<unk>  is toxic to inhalation, ingestion, or skin contact, although the intoxication may be delayed. According to the U.S. National Institute for Occupational Safety and Health (NIOSH), the recommended workplace airborne exposure limit is 0.3 mg/m3 averaged over a 10-hour workshift. Exposure to 100 mg/m3 is immediately dangerous to life and health. The lethal dose in humans is approximately 4 g/kg. Effects on animals An oral dose of 3 mg per kilogram of body weight causes the death of 50% of the rats exposed (), showing a very high selectivity when compared for example to monkeys ( 4000 mg per kilogram of body weight). However other studies have shown a much higher efficacy for dogs (a of 0.38 mg/kg). The mortality of rats caused by 5 mg/kg of<unk>  is reduced when allylthiourea, isopropylthiourea, ethylenethiourea, or ethylidenethiourea are administered simultaneously with<unk> . Superoxide dismutase, catalase and dimethylsulfoxide all protect against the lung damage by<unk>  (although the results are diverse). This indicates that OH radicals are responsible for this type of lung injury. Given hydroxurea over 2 days doesn't block the<unk>  damage when neutrophils are decreased or when administered acutely. Cyclooxygenase pathway may generate the free radicals since ibuprofen blocked as well the<unk>  damage. + Toxicity of<unk>  in different animals Organism Test type Route Reported dose Cat LD50 oral 500 mg/kg Chicken LD50 intraperitoneal 2500 mg/kg Chicken LD50 oral 4250 mg/kg Chicken LD50 unreported 700 mg/kg Dog LD50 intraperitoneal 16 mg/kg Dog LD50 oral 0.38 mg/kg Guinea pig LD50 intraperitoneal 350 mg/kg Man LDLo unreported 588 mg/kg Monkey LD50 intraperitoneal 175 mg/kg Monkey LD50 oral 4250 mg/kg Monkey LD50 unreported 2000 mg/kg Mouse LD50 intraperitoneal 10 mg/kg Mouse LD50 oral 5 mg/kg Pig LDLo oral 50 mg/kg Rabbit LD50 unreported 200 mg/kg Rat LD50 intraperitoneal 2.47 mg/ kg Rat LD50 oral 6 mg/kg<unk>  causes local gastric irritation in animals and when it is absorbed, it increases permeability of the lung capillaries in all animals. The symptoms that the animals present after absorption of<unk>  are first weakness, ataxia, weak pulse and subnormal temperatures. Afterwards, they have the following symptoms: vomiting, hypersalivation, coughing and severe pulmonary edema. In the most cases a pale, mottled liver and damaged kidneys are found in animals which have ingested<unk> . Animals with an empty stomach readily vomit after ingestion of this substance. However, when there is food in the stomach of the animals the stimulation to vomit decreases, so more quantities may be absorbed. It has been found that<unk>  may cause death in some animals within 2–4 hours of ingestion, while animals that survive 12 hours may recover from the poison. In a long-term,<unk>  may cause pulmonary edema and pleural effusion in certain animals, such as rats. Mice treated with<unk>  with a dose of 10 mg/kg developed pulmonary edema which was maximal after 3 hours and was resolved by 12 hours. 35 mg/kg of<unk>  was caused death to 60% of the animals. It also increases the blood sugar levels in rats. Dogs and pigs are occasionally poisoned with this compound while ruminants are resistant. But when the exposure of this compound in dogs is quite long they may have gastric irritation and respiratory difficulties. Death can then be followed within 6–48 hours depending on the quantity of<unk>  ingested.
Alpha-Naphthylthiourea
Arabinopyranosyl-N-methyl-N-nitrosourea
Trenbolone hexahydrobenzylcarbonate
Gadobenic acid
Penicilloic acid
Dimethyl methylphosphonate
Silver diammine fluoride
Tienilic acid