<unk>  may be broadly divided into hereditary and sporadic forms. Hereditary<unk>  is usually transmitted in an autosomal dominant manner (each offspring has a 50% chance of being affected), although rare autosomal recessive forms (such as Gillespie syndrome) have also been reported. Sporadic<unk>  mutations may affect the WT1 region adjacent to the AN2<unk>  region, causing a kidney cancer called nephroblastoma (Wilms tumor). These patients often also have genitourinary abnormalities and intellectual disability (WAGR syndrome). Several different mutations may affect the PAX6 gene. Some mutations appear to inhibit gene function more than others, with subsequent variability in the severity of the disease. Thus, some<unk>  individuals are only missing a relatively small amount of iris, do not have foveal hypoplasia, and retain relatively normal vision. Presumably, the genetic defect in these individuals causes less "heterozygous insufficiency," meaning they retain enough gene function to yield a milder phenotype. * AN *<unk>  and absent patella *<unk> , microcornea, and spontaneously reabsorbed cataract *<unk> , cerebellar ataxia, and mental deficiency (Gillespie syndrome)
Aniridia
Xanthochromia
Microphthalmia
Heterochromia iridum
Macrodontia 
Spotted lunulae
Onychoschizia
Dyschromia