Corneal clouding visible in the eye of a 30-year-old male with MPS VI Dermatan sulfate is one of the GAGs that builds up in the tissues of people with MPS-VI Unlike other MPS diseases, children with<unk>  usually have normal intelligence. They share many of the physical symptoms found in Hurler syndrome.<unk>  has a variable spectrum of severe symptoms. Neurological complications include clouded corneas, deafness, thickening of the dura (the membrane that surrounds and protects the brain and spinal cord), and pain caused by compressed or traumatized nerves and nerve roots. Signs are revealed early in the affected child's life, with one of the first symptoms often being a significantly prolonged age of learning how to walk. Growth begins normally, but children usually stop growing by age 8. By age 10, children often develop a shortened trunk, crouched stance, and restricted joint movement. In more severe cases, children also develop a protruding abdomen and forward-curving spine. Skeletal changes, particularly in the pelvis, are progressive and limit movement. Many children also have umbilical hernia or inguinal hernias. Nearly all children have some form of heart disease, usually involving the heart valves.
Maroteaux–Lamy syndrome
Mucopolysaccharidosis
Coffin–Siris syndrome
Griscelli syndrome type 2
Dunnigan familial partial lipodystrophy
Wilson–Mikity syndrome
Marfanoid–progeroid–lipodystrophy syndrome
Gianotti–Crosti syndrome