The mechanisms by which the virus is contracted are not well understood. Healthy individuals can be infected with the virus and show no signs or symptoms, due to the immune system's ability to keep the infection in check. Infection is of particular concern to the immunocompromised. Cancer patients receiving chemotherapy, AIDS patients, and organ transplant patients are all at a high risk of showing signs of infection.. Recent advances in sequencing technologies have uncovered that virus is chromatinized during latency. It has also been shown that virus encoded microRNA manipulates and interacts not only with host mRNA but also deregulate host long non-coding RNA (lncRNA). More recently, circularRNAs (circRNAs) are recently discovered in both EBV and<unk>  Infection with this virus is thought to be lifelong, but a healthy immune system will keep the virus in check. Many people infected with<unk>  will never show any symptoms.<unk> 's<unk>  occurs when someone who has been infected with<unk>  becomes immunocompromised due to AIDS, medical treatment, or, very rarely, aging.<unk>  is a known causative agent of four diseases: *<unk> 's<unk>  – an angioproliferative tumor that can involve skin (most often), lymph nodes, or viscera, * HHV-8-associated multicentric Castleman's disease – a lymphoproliferative disorder, * Primary effusion lymphoma –<unk><unk>  aggressive lymphoma involving B-cells that are immature plasma cells termed plasmablasts and regarded as one type of lymphoid neoplasms with plasmablastic differentiation, *<unk>  inflammatory cytokine syndrome – a syndrome with MCD-like symptoms but without<unk>  pathology.
Kaposi's sarcoma-associated herpesvirus
Human T-lymphotropic virus 2
Trichodysplasia spinulosa polyomavirus
Human T-lymphotropic virus 1
SV40 large T antigen
Human T-lymphotropic virus
Subtypes of HIV
Epstein–Barr virus viral-capsid antigen