<unk>  <unk> -OH-7α-TMS) is a steroidal antimineralocorticoid of the spirolactone group and a major active metabolite of spironolactone. Other important metabolites of spironolactone include<unk> -thiospironolactone <unk> -TS; SC-24813),<unk> -thiomethylspironolactone <unk> -TMS; SC-26519), and canrenone (SC-9376). Spironolactone is a prodrug with a short terminal half-life of 1.4 hours. The active metabolites of spironolactone have extended terminal half-lives of 13.8 hours for<unk> -TMS, 15.0 hours for<unk> -OH-7α-TMS, and 16.5 hours for canrenone, and accordingly, these metabolites are responsible for the therapeutic effects of the drug.<unk><unk> testosterone, which is analogous to<unk> -OH-7α-TMS, has been found to possess virtually no androgenicity.
6β-Hydroxy-7α-thiomethylspironolactone
7α-Thiomethylspironolactone
7α-Thiospironolactone
11β-Methyl-19-nortestosterone dodecylcarbonate
Desoxycorticosterone acetate
Desoxycorticosterone pivalate
Testosterone enanthate
Recombinant human parathyroid hormone