MRI images of three patients in the sagittal plane. A and B: Complete<unk> . C: Complete<unk>  of both the<unk><unk>  and the anterior commissure. Signs and symptoms of<unk>  and other callosal disorders vary greatly among individuals. However, some characteristics common in individuals with callosal disorders include vision impairments, low muscle tone (hypotonia), poor motor coordination, delays in motor milestones such as sitting and walking, delayed toilet training and dysautonomic symptoms such as low perception of pain or chewing and swallowing difficulties. Laboratory research has demonstrated that individuals with<unk>  have difficulty transferring more complex information from one hemisphere to the other. They also have been shown to have some cognitive disabilities (difficulty in complex problem solving) and social difficulties (missing subtle social cues), even when their intelligence quotient is normal. Recent research suggests that specific social difficulties may be a result of impaired face processing. The unusual social behavior in childhood often resembles that of an autism spectrum disorder. Other characteristics sometimes associated with callosal disorders include seizures, spasticity, early feeding difficulties and/or gastric reflux, hearing impairments, abnormal head and facial features, and intellectual disability. Associated brain anomalies Brain anomalies that can sometimes occur in syndromes that cause callosal disorders include: * Aplasia of the cerebellar vermis * Chiari malformation * Colpocephaly * Dandy–Walker syndrome * Holoprosencephaly * Hydrocephalus * Neuronal migration disorders such as grey matter heterotopia * Schizencephaly Associated syndromes and conditions Some syndromes that frequently include<unk>  are: * Acrocallosal syndrome * Aicardi syndrome * Andermann syndrome * Donnai–Barrow syndrome * Dwarfism * FG syndrome * L1CAM syndrome * Microcephalic osteodysplastic primordial dwarfism type II * Mowat–Wilson syndrome * Oculocerebrocutaneous syndrome * Saal Bulas syndrome * Septo-optic dysplasia (optic nerve hypoplasia) * Shapiro syndrome * Vici syndrome Some conditions that can sometimes be associated with<unk>  or other callosal disorders include: * 1p36 deletion syndrome * 13q deletion syndrome * CDK13-related disorder * Craniofacial abnormalities and other oral and maxillofacial pathologies * Fetal alcohol syndrome * Fetal warfarin syndrome * Genitopatellar syndrome * Gomez-Lopez-Hernandez syndrome * Joubert syndrome * Lujan–Fryns syndrome * Marden–Walker syndrome * Maternal nutritional deficiencies or infections * Metabolic disorders * Okamoto syndrome * Opitz G/BBB syndrome * Pascual-Castroviejo syndrome * Pitt–Hopkins syndrome * Sensenbrenner syndrome * Strømme syndrome * Triploid syndrome * Trisomy 9 * Xia-Gibbs syndrome
Agenesis of the corpus callosum
Germinal matrix hemorrhage
Congenital bilateral perisylvian syndrome
Cerebellar agenesis
Gray matter heterotopia
Bilateral frontoparietal polymicrogyria
Cerebellar hypoplasia
Pontocerebellar hypoplasia