SCS is the most common craniosynostosis syndrome and affects 1 in every 25,000 to 50,000 individuals. It occurs in all racial and ethnic groups, and affects males and females equally. If a parent carries a copy of the SCS gene mutation, then there is a 50% chance their child will also carry a copy of the gene mutation, in which case, the child may or may not show signs of SCS. There is also a 50% chance their child will have two working copies of the gene, and would therefore, not have SCS. If both parents carry a single copy of the SCS gene mutation, then there is a 25% chance their child will have two gene mutation copies (so child would develop severe SCS), a 25% chance their child would have two normal copies of the gene (so would be completely normal), and a 50% chance their child would carry one gene mutation copy and 1 normal copy (so child may or may not display SCS). In rare situations, two normal parents can have a child with SCS due to a de novo mutation. The exact cause of the de novo mutation is unknown, but it doesn't seem to be related to anything that the parents did or didn't do during the pregnancy. SCS due to a de novo mutation is so rare that the proportion of past cases is unknown.
Saethre–Chotzen syndrome
Pelger–Huët anomaly
Goldberg–Shprintzen syndrome
Marshall–Smith syndrome
Langer–Giedion syndrome
Bardet–Biedl syndrome
Smith–Magenis syndrome
Schinzel–Giedion syndrome