As there is no cure for<unk> , therapy is focused on the management of symptoms and improvement of quality of life of affected individuals. Treatment of<unk>  is similar to treatment of typical Parkinson’s disease and is mainly composed of a combination of two medications called levodopa (L-DOPA) and carbidopa. The goal of this medication is to alleviate motor symptoms by increasing the concentration of dopamine in the nervous system. Dopamine receptor agonists can also be used. Trihexylphenidyl and amantadine might also be prescribed, especially in cases where dopaminergic medication is not effective or tolerated. Botulinum toxin (Botox) can be used to treat dystonia. Medication is only used to control the symptoms of the disease (symptomatic treatment), not to cure it. Benefits of medication are mostly for motor symptoms, and have no significant effect on non-motor symptoms of KRS. Physical, occupational and/or speech therapy can also be useful interventions. Treatment options for non-motor symptoms are more limited. Individuals living with<unk>  might also require a walking aid or a wheelchair. Special education might be indicated, as intellectual disability and learning difficulties are common in KRS. The help of caregivers or health professionals might also be necessary to perform activities of daily living, depending on the severity of the disease. Genetic counselling services should be offered to affected families.
Kufor–Rakeb syndrome
Kufs disease
Zunich–Kaye syndrome
Irlen syndrome
Simpson–Golabi–Behmel syndrome
Naxos syndrome
Cornelia de Lange syndrome
Letterer–Siwe disease