<unk>  is a component of the innate immune system that functions as a pattern recognition receptor (PRR) that recognizes pathogen-associated molecular patterns (PAMPs).<unk>  belongs to the NOD-like receptor (NLR) subfamily of PRRs and<unk>  together with the adaptor ASC protein PYCARD forms a caspase-1 activating complex known as the<unk>  inflammasome.<unk>  in the absence of activating signal is kept in an inactive state complexed with HSP90 and SGT1 in the cytoplasm.<unk>  inflammasome detects danger signals such as crystalline uric acid and extracellular ATP released by damaged cells. These signals release HSP90 and SGT1 from and recruit ASC protein and caspase-1 to the inflammasome complex. Caspase-1 within the activated<unk>  inflammasome complex in turn activates the inflammatory cytokine, IL-1β. The<unk>  inflammasome appears to be activated by changes in intracellular potassium caused by potassium efflux from mechanosensitive ion channels located in the cell membrane. It appears that<unk>  is also regulated by reactive oxygen species (ROS), though the precise mechanisms of such regulation has not been determined. It is suggested that<unk>  provides protection against Streptococcus pneumoniae infections by activating STAT6 and SPDEF.
NLRP3
Caspase-9
PTPRC
Rho
MFAP4
IKK2
ILC2
Fc receptor