Although<unk> s are much safer in overdose than their predecessors, the barbiturates, they can still cause problems in overdose. Taken alone, they rarely cause severe complications in overdose; statistics in England showed that<unk> s were responsible for 3.8% of all deaths by poisoning from a single drug. However, combining these drugs with alcohol, opiates or tricyclic antidepressants markedly raises the toxicity. The elderly are more sensitive to the side effects of<unk> s, and poisoning may even occur from their long-term use. The various<unk> s differ in their toxicity; temazepam appears most toxic in overdose and when used with other drugs. The symptoms of a<unk>  overdose may include; drowsiness, slurred speech, nystagmus, hypotension, ataxia, coma, respiratory depression, and cardiorespiratory arrest. A reversal agent for<unk> s exists, flumazenil (Anexate). Its use as an antidote is not routinely recommended because of the high risk of resedation and seizures. In a double-blind, placebo-controlled trial of 326 people, 4 people had serious adverse events and 61% became resedated following the use of flumazenil. Numerous contraindications to its use exist. It is contraindicated in people with a history of long-term use of<unk> s, those having ingested a substance that lowers the seizure threshold or may cause an arrhythmia, and in those with abnormal vital signs. One study found that only 10% of the people presenting with a<unk>  overdose are suitable candidates for treatment with flumazenil.
Benzodiazepine
Synthetic cannabinoids
Antidepressant
Alcohol 
Gabapentinoid
Substituted amphetamine
Methamphetamine
Antipsychotic