<unk>  is an interferon-stimulated gene whose expression inhibits many DNA and RNA viruses including CHIKV, HCMV, HCV, DENV, WNV, SINV, influenza, and HIV. Initially identified as an IFN-γ induced antiviral protein in human cytomegalovirus (HCMV) infected macrophages, it was reported that<unk>  could be induced by HCMV glycoprotein B in fibroblasts, but inhibits HCMV viral infection and down-regulates viral structural proteins. The reason why virus protein would induce<unk>  against itself is still not clear; however, the viral induced redistribution of<unk>  may reflect the mechanism of virus evading its antiviral activities.<unk>  may also be induced and interact with HCMV viral proteins and relocate to mitochondria in HCMV viral infected cells to enhance viral infectivity by disrupting cellular metabolism.<unk>  is a radical SAM enzyme which is capable of producing the chain terminator ddhCTP (3ʹ-deoxy-3′,4ʹdidehydro-CTP), which inhibits the viral RNA dependent RNA polymerase (RdRp). This activity appears to abolish metabolism of amino acids and mitochondrial respiration. In the inhibition of influenza virus budding and release,<unk>  is suggested to disrupt the lipid rafts on the cell's plasma membrane by binding to and decreasing the enzyme activities of farnesyl diphosphate synthase (FPPS), an essential enzyme in isoprenoid biosynthesis pathway.<unk>  was suggested to inhibit the viral replication of HCV via its interaction with host protein hVAP-33 and NS5A and disrupting the formation of the replication complex.
Viperin
Latrotoxin
Alpha-neurotoxin
Bukatoxin
Bungarotoxin
Tetrahydrocannabinol
Brevetoxin
Neurotoxin