<unk> . is an open-source non-profit web application that allows members of the public to use their data from direct-to-consumer (DTC) genetic tests (including tests from 23andMe and Ancestry.com) to calculate polygenic risk scores (PRS) for complex diseases and cognitive and personality traits.<unk>  calculates PRSs, which are used to estimate the risk of developing complex diseases from the combined effects of numerous common single nucleotide polymorphisms in the human genome. It is intended for use by people who have obtained genetics data from a direct to consumer genetic testing company. If they upload the files, the uploaded data is expanded into ungenotyped SNPs and the overlap with public GWAS summary statistics used to estimate risk. The data is then subjected to analysis scripts including PRS calculations for approximately 2,000 traits and complex diseases. PRSs are calculated based on the combined effect of all SNPs reported in the summary statistics of the underlying GWAS or of the top, genome-wide significant SNPs in the underlying GWAS. The scores based on all SNPs are only available for about 20 complex diseases and traits. Users can then make use of the web tool GenoPred to translate their PRSs onto an absolute risk scale using summary statistics from the GWAS studies.
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