<unk>  is a clinical<unk>  in which there is twitching of the outer margins of the eyes and mouth. It is an early<unk>  of general paralysis of the insane. The<unk>  was described by Sir James<unk><unk> .
Crichton-Browne sign
Bastian–Bruns sign
Claybrook sign
Cullen's sign
Froment's sign
Boas' sign
Bing's sign
Gordon's sign