The connecting peptide, or<unk> , is a short 31-amino-acid polypeptide that connects insulin's A-chain to its B-chain in the proinsulin molecule. In the context of diabetes or hypoglycemia, a measurement of<unk>  blood serum levels can be used to distinguish between different conditions with similar clinical features. In the insulin synthesis pathway, first preproinsulin is translocated into the endoplasmic reticulum of beta cells of the pancreas with an A-chain, a<unk> , a B-chain, and a signal sequence. The signal sequence is cleaved from the N-terminus of the peptide by a signal peptidase, leaving proinsulin. After proinsulin is packaged into vesicles in the Golgi apparatus (beta-granules), the<unk>  is removed, leaving the A-chain and B-chain bound together by disulfide bonds, that constitute the insulin molecule.
C-peptide
Leptin
Glucagon-like peptide-1
Insulin index
Insulin tolerance test
Adiponectin
Ghrelin
Nesfatin-1