The most common side effects are flu-like symptoms and include fever, rash, dermatographism, hyperpigmentation, alopecia (hair loss), chills, and Raynaud's phenomenon (discoloration of fingers and toes). The most serious complication of<unk> , occurring upon increasing dosage, is pulmonary fibrosis and impaired lung function. It has been suggested that<unk>  induces sensitivity to oxygen toxicity and recent studies support the role of the proinflammatory cytokines IL-18 and IL-1beta in the mechanism of<unk> -induced lung injury. Any previous treatment with<unk>  should therefore always be disclosed to the anaesthetist prior to undergoing a procedure requiring general anaesthesia. Due to the oxygen sensitive nature of<unk> , and the theorised increased likelihood of developing pulmonary fibrosis following supplemental oxygen therapy, it has been questioned whether patients should take part in scuba diving following treatment with the drug.<unk>  has also been found to disrupt the sense of taste. Warning<unk>  should not exceed a lifetime cumulative dose greater than 400 units. Pulmonary toxicities, most commonly presenting as pulmonary fibrosis, are associated with doses of<unk>  greater than 400 units.
Bleomycin
Ifosfamide
Vincristine
Doxorubicin
Epirubicin
Etoposide
Mitoxantrone
Daunorubicin