Mechanical stimulation The most common<unk> s are pressure<unk> s, caused by rubbing or applying pressure on or near the closed eyes. They have been known since antiquity, and described by the Greeks. The pressure mechanically stimulates the cells of the retina. Experiences include a darkening of the visual field that moves against the rubbing, a diffuse colored patch that also moves against the rubbing, well defined shapes such as bright circles that exist near or opposite to where pressure is being applied, a scintillating and ever-changing and deforming light grid with occasional dark spots (like a crumpling fly-spotted flyscreen), and a sparse field of intense blue points of light. Pressure<unk> s can persist briefly after the rubbing stops and the eyes are opened, allowing the<unk> s to be seen on the visual scene. Hermann von Helmholtz and others have published drawings of their pressure<unk> s. One example of a pressure<unk>  is demonstrated by gently pressing the side of one's eye and observing a colored ring of light on the opposite side, as detailed by Isaac Newton. Another common<unk>  is "seeing stars" from a sneeze, laughter, a heavy and deep cough, blowing of the nose, a blow on the head or low blood pressure (such as on standing up too quickly or prior to fainting). It is possible these involve some mechanical stimulation of the retina, but they may also involve mechanical and metabolic (such as from low oxygenation or lack of glucose) stimulation of neurons of the visual cortex or of other parts of the visual system. Less commonly,<unk> s can also be caused by some diseases of the retina and nerves, such as multiple sclerosis. The British National Formulary lists<unk> s as an occasional side effect of at least one anti-anginal medication. The name<unk> " was coined by J. B. H. Savigny, better known as the ship's surgeon of the wrecked French frigate Méduse. It was first employed by Serre d'Uzes to test retinal function prior to cataract surgery. Electrical stimulation<unk> s have been created by electrical stimulation of the brain, reported by neurologist Otfrid Foerster as early as 1929. Brindley and Lewin (1968) inserted a matrix of stimulating electrodes directly into the visual cortex of a 52-year-old blind female, using small pulses of electricity to create<unk> s. These<unk> s were points, spots, and bars of colorless or colored light. Brindley and Rushton (1974) used the<unk> s to create a visual prosthesis, in this case by using the<unk> s to depict Braille spots. In recent years, researchers have successfully developed experimental brain–computer interfaces or neuroprostheses that stimulate<unk> s to restore vision to people blinded through accidents. Notable successes include the human experiments by William H. Dobelle and Mark Humayun and animal research by Dick Normann. A noninvasive technique that uses electrodes on the scalp, transcranial magnetic stimulation, has also been shown to produce<unk> s. Experiments with humans have shown that when the visual cortex is stimulated above the calcarine fissure,<unk> s are produced in the lower part of the visual field, and vice versa. Others<unk> s have been produced by intense, changing magnetic fields, such as with transcranial magnetic stimulation (TMS). These fields can be positioned on different parts of the head to stimulate cells in different parts of the visual system. They also can be induced by alternating currents that entrain neural oscillation as with transcranial alternating current stimulation. In this case they appear in the peripheral visual field. This claim has been disputed. The alternative hypothesis is that current spread from the occipital electrode evokes<unk> s in the retina.<unk> s created by magnetic fields are known as magnetophosphenes. Astronauts exposed to radiation in space have reported seeing<unk> s. Patients undergoing radiotherapy have reported seeing blue flashes of light during treatment; the underlying phenomenon has been shown to resemble Cherenkov radiation.<unk> s can be caused by some medications, such as Ivabradine.
Phosphene
Magnetophosphene
Theobromine
Toxaphene
Desmethylchlorotrianisene
Chlorotrianisene
Menthol
Esthiomene