<unk> s <unk> s) are a class of drugs that inhibit the activity of one or both<unk><unk>  enzymes:<unk><unk>  A (MAO-A) and<unk><unk>  B (MAO-B). They are best known as highly efficacious anti-depressants, as well as effective therapeutic agents for panic disorder and social phobia. They are particularly effective in treatment-resistant depression and atypical depression. They are also used in the treatment of Parkinson's disease and several other disorders. Reversible inhibitors of<unk><unk>  A (RIMAs) are a subclass of<unk> s that selectively and reversibly inhibit the MAO-A enzyme. RIMAs are used clinically in the treatment of depression and dysthymia. Due to their reversibility, they are safer in single-drug overdose than the older, irreversible<unk> s, and weaker in increasing the<unk> s important in depressive disorder. RIMAs have not gained widespread market share in the United States. How RIMAs work and why RIMAs can only minimally increase depression-related neurotransmitters
Monoamine oxidase inhibitor
Acetylcholinesterase inhibitor
Dopamine antagonist
Enkephalinase inhibitor
Monoamine reuptake inhibitor
Norepinephrine reuptake inhibitor
Glycine reuptake inhibitor
Opioid antagonist