Postsynaptic NMDA receptors are highly sensitive to the membrane potential (see coincidence detection in neurobiology). Due to their high permeability for calcium, they generate a local chemical signal that is largest when the back-propagating action potential in the dendrite arrives shortly after the synapse was active (pre-post<unk> ng). Large postsynaptic calcium transients are known to trigger synaptic potentiation (Long-term potentiation). The mechanism for<unk><unk><unk>  depression is less well understood, but often involves either postsynaptic voltage-dependent calcium entry/mGluR activation, or retrograde endocannabinoids and presynaptic NMDARs.
Spike-timing-dependent plasticity
Neuronal tuning
Depolarization-induced suppression of inhibition
Intermuscular coherence
Presynaptic inhibition
Parafunctional activity
Neural adaptation
Lateral inhibition