<unk>  at concentration between 0.1 and 100 μM stimulates in a dose-dependent manner sGC activity up to 73-fold. In addition, it acts synergistically with diethylamine/NO, the donor of NO, to increase sGC activity in vitro up to 112-fold. A phase I study showed that<unk>  is rapidly absorbed, and maximum plasma concentration is reached between 0.5–1.5 h. The mean elimination half-life appears to be 5–10 hours.<unk>  plasma concentrations have been also shown to be quite variable between patients, indicating that for clinical use it is probably necessary to titrate the drug specifically for each individual.
Riociguat
Vericiguat
Sitaxentan
Cangrelor
Clemastine
Darusentan
Nafoxidine
Bosentan