Adverse effects can involve the tendons, muscles, joints, nerves, and the central nervous system. Rates of adverse effects appear to be higher than with some groups of antibiotics such as cephalosporins but lower than with others such as clindamycin. Compared to other antibiotics some studies find a higher rate of adverse effects while others find no difference. In clinical trials most of the adverse events were described as mild or moderate in severity, abated soon after the drug was discontinued, and required no treatment. Some adverse effects may be permanent.<unk>  was stopped because of an adverse event in 1% of people treated with the medication by mouth. The most frequently reported drug-related events, from trials of all formulations, all dosages, all drug-therapy durations, and for all indications, were nausea (2.5%), diarrhea (1.6%), abnormal liver function tests (1.3%), vomiting (1%), and rash (1%). Other adverse events occurred at rates of 2). Results from photo co-carcinogenicity testing indicate<unk>  does not reduce the time to appearance of UV-induced skin tumors as compared to vehicle control. Other The other black box warning is that<unk>  should not be used in people with myasthenia gravis due to possible exacerbation of muscle weakness which may lead to breathing problems resulting in death or ventilator support. Fluoroquinolones are known to block neuromuscular transmission. There are concerns that fluoroquinolones including<unk>  can affect cartilage in young children. Clostridium difficile-associated diarrhea is a serious adverse effect of<unk>  and other fluoroquinolones; it is unclear whether the risk is higher than with other broad-spectrum antibiotics. A wide range of rare but potentially fatal adverse effects reported to the U.S. FDA or the subject of case reports includes aortic dissection, toxic epidermal necrolysis, Stevens–Johnson syndrome, low blood pressure, allergic pneumonitis, bone marrow suppression, hepatitis or liver failure, and sensitivity to light. The medication should be discontinued if a rash, jaundice, or other sign of hypersensitivity occurs. Children and the elderly are at a much greater risk of experiencing adverse reactions.
Ciprofloxacin
Norfloxacin
Meropenem
Sparfloxacin
Colistin
Ofloxacin
Cethromycin
Metronidazole