Guidelines for management of patients up to 18 years with<unk>  have been suggested. Treatment is guided by extent of disease. Solitary bone lesion may be amenable through excision or limited radiation, dosage of 5-10 Gy for children, 24-30 Gy for adults. However systemic diseases often require chemotherapy. Use of systemic steroid is common, singly or adjunct to chemotherapy. Local steroid cream is applied to skin lesions. Endocrine deficiency often require lifelong supplement e.g. desmopressin for diabetes insipidus which can be applied as nasal drop. Chemotherapeutic agents such as alkylating agents, antimetabolites, vinca alkaloids either singly or in combination can lead to complete remission in diffuse disease.
Langerhans cell histiocytosis
X-type histiocytosis
Sea-blue histiocytosis
Malignant histiocytosis
Crystal-storing histiocytosis
Non-X histiocytosis
Progressive nodular histiocytosis
Langerhans cell sarcoma