As biosystems are unable to store<unk> , regular intake is necessary. Excessively low<unk>  intake can lead to<unk> , which can negatively impact an individual's health. The mechanisms for the clinical manifestations of<unk>  are best appreciated by recognizing that<unk>  functions in the body in three areas: catalytic, structural, and regulatory.<unk>  (Zn) is only common in its +2 oxidative state, where it typically coordinates with tetrahedral geometry. It is important in maintaining basic cellular functions such as DNA replication, RNA transcription, cell division and cell activations. However, having too much or too little<unk>  can cause these functions to be compromised.<unk>  is a critical component of the catalytic site of hundreds of kinds of different metalloenzymes in each human being. In its structural role,<unk>  coordinates with certain protein domains, facilitating protein folding and producing structures such as 'zinc fingers'. In its regulatory role,<unk>  is involved in the regulation of nucleoproteins and the activity of various inflammatory cells. For example,<unk>  regulates the expression of metallothionein, which has multiple functions, such as intracellular<unk>  compartmentalization and antioxidant function. Thus<unk>  results in disruption of hundreds of metabolic pathways, causing numerous clinical manifestations, including impaired growth and development, and disruption of reproductive and immune function. Pra1 (pH regulated antigen 1) is a candida albicans protein that scavenges host<unk> .
Zinc deficiency
Zinc toxicity
Manganese deficiency 
Boron deficiency 
Lead poisoning
Iron deficiency
Selenium deficiency
Copper deficiency