Simplified model of<unk> R activation and various types of<unk> R blockers. The<unk>  receptor is an ionotropic receptor that allows for the transfer of electrical signals between neurons in the brain and in the spinal column. For electrical signals to pass, the<unk>  receptor must be open. To remain open, glutamate and glycine must bind to the<unk>  receptor. An<unk>  receptor that has glycine and glutamate bound to it and has an open ion channel is called "activated." Chemicals that deactivate the<unk>  receptor are called antagonists.<unk> R antagonists fall into four categories: Competitive antagonists, which bind to and block the binding site of the neurotransmitter glutamate; glycine antagonists, which bind to and block the glycine site; noncompetitive antagonists, which inhibit<unk> Rs by binding to allosteric sites; and uncompetitive antagonists, which block the ion channel by binding to a site within it.
NMDA receptor antagonist
Glycine receptor antagonist
GABA reuptake inhibitor
GABA analogue
Dopamine antagonist
Adenosine reuptake inhibitor
Serotonin receptor agonist
GABAA receptor positive allosteric modulator