<unk>  is a drug that conducts the blood pressure lowering effects by vasoconstrictive repression. It is a direct-acting smooth muscle relaxant and acts as a vasodilator primarily in resistance arterioles, also known as the smooth muscle of the arterial bed. The molecular mechanism involves inhibition of inositol trisphosphate-induced Ca2+ release from the sarcoplasmic reticulum in arterial smooth muscle cells. By relaxing vascular smooth muscle, vasodilators act to decrease peripheral resistance, thereby lowering blood pressure and decreasing afterload.
Hydralazine
Captopril
Chlorothiazide
Cyclothiazide
Furosemide
Metoprolol
Hydrochlorothiazide
Nebivolol