<unk> -IMS involves the visualization of the spatial distribution of proteins, peptides, lipids, and other small molecules within thin slices of tissue, such as animal or plant. The application of this technique to biological studies has increased significantly since its introduction.<unk> -IMS is providing major contributions to the understanding of diseases, improving diagnostics, and drug delivery. Significant studies are of the eye, cancer research, drug distribution, and neuroscience.<unk> -IMS has been able to differentiate between drugs and metabolites and provide histological information in cancer research, which makes it a promising tool for finding new protein biomarkers. However, this can be challenging because of ion suppression, poor ionization, and low molecular weight matrix fragmentation effects. To combat this, chemical derivatization is used to improve detection.
MALDI imaging
Eagle score
Welner table
Lund and Browder chart
Tile classification
Holtzman inkblot technique
Ogden tables
QPNC-PAGE