Combination with SSRIs/SNRIs, SRAs, serotonin receptor agonists may lead to potentially lethal serotonin syndrome. Combination with MAOIs may also result in an adrenergic storm. Use of<unk>  with alcohol or other sedatives such as benzodiazepines, barbiturates, nonbenzodiazepines, phenothiazines, and other opiates may result in increased impairment, sedation, respiratory depression, and death.<unk>  is partially metabolized by the hepatic enzymes CYP2C9, CYP2C19, and CYP2D6 so it innately has interactions with drugs that enhance or repress the activity/expression of one or more of these enzymes, as well as with substrates of these enzymes (due to competition for the enzyme); some enzyme mediators/substrates require dosing adjustments to one or both medications. The combination of<unk>  and alcohol may result in increased plasma concentrations of<unk>  and produce respiratory depression to a degree greater than the sum of the two drugs when administered separately; patients should be cautioned against alcohol consumption when taking<unk>  as the combination may be fatal.<unk>  should be used with caution in patients who are taking one or more anticholinergic drugs, as this combination may result in urine retention (which can result in serious renal damage and is considered a medical emergency).
Tapentadol
Tramadol
Desmetramadol
Acetylmethadol
Hydrocodone
Etodolac
Ketorolac
Noroxycodone