<unk>  is the major metabolite of the opioid analgesic oxycodone. It is formed from oxycodone in the liver via N-demethylation predominantly by CYP3A4.<unk>  binds to and activates the μ-opioid receptor (MOR) similarly to oxycodone, although with one-third of the affinity of oxycodone and 5- to 10-fold lower activational potency. However, although a potent MOR agonist,<unk>  poorly crosses the blood-brain-barrier into the central nervous system, and for this reason, is only minimally analgesic in comparison.
Noroxycodone
Norhydrocodone
Hydrocodone
Oxycodone
Pafolacianine
Extended-release morphine
Morphine
Oxymorphone