<unk>  type 1 (HFE-related<unk>  is a genetic disorder characterized by excessive intestinal absorption of dietary iron, resulting in a pathological increase in total body iron stores. Humans, like most animals, have no means to excrete excess iron, with the exception of menstruation which, for the average woman, results in a loss of 3.2 mg of iron. Excess iron accumulates in tissues and organs, disrupting their normal function. The most susceptible organs include the liver, heart, pancreas, skin, joints, gonads, thyroid and pituitary gland; patients can present with cirrhosis, polyarthropathy, hypogonadism, heart failure, or diabetes. There are 5 types of<unk> : type 1, 2 (2A, 2B), 3, 4 and 5, all caused by mutated genes.<unk>  is the most frequent, and unique related to the HFE gene. It is most common among those of Northern European ancestry, in particular those of Celtic descent. The disease is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. Most often, the parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but do not express signs or symptoms of the condition. In this situation, the otherwise unaffected parents are referred to as carriers.
Hereditary haemochromatosis
Hemochromatosis type 4
Juvenile hemochromatosis
Haemochromatosis type 3
Aceruloplasminemia
Non-alcoholic fatty liver disease
Familial cirrhosis
Wilson's disease