Symptoms of<unk>  metastasis depend on the location of the tumor. When<unk>  begins, it produces no symptoms. Signs and symptoms appear as the mass grows or ulcerates. The findings that result depend on the<unk> 's type and location. Few symptoms are specific. Many frequently occur in individuals who have other conditions.<unk> <unk> n be difficult to diagnose and<unk> n be considered a "great imitator." People may become anxious or depressed post-diagnosis. The risk of suicide in people with<unk>  is approximately double. Local symptoms Local symptoms may occur due to the mass of the tumor or its ulceration. For example, mass effects from lung<unk> <unk> n block the bronchus resulting in cough or pneumonia; esophageal<unk> <unk> n<unk> use narrowing of the esophagus, making it difficult or painful to swallow; and colorectal<unk>  may lead to narrowing or blockages in the bowel, affecting bowel habits. Masses in breasts or testicles may produce observable lumps. Ulceration<unk> n<unk> use bleeding that<unk> n lead to symptoms such as coughing up blood (lung<unk> , anemia or rectal bleeding (colon<unk> , blood in the urine (bladder<unk> , or abnormal vaginal bleeding (endometrial or cervical<unk> . Although localized pain may occur in advanced<unk> , the initial tumor is usually painless. Some<unk> s<unk> n<unk> use a buildup of fluid within the chest or abdomen. Systemic symptoms Systemic symptoms may occur due to the body's response to the<unk> . This may include fatigue, unintentional weight loss, or skin changes. Some<unk> s<unk> n<unk> use a systemic inflammatory state that leads to ongoing muscle loss and weakness, known as<unk> chexia. Some<unk> s, such as Hodgkin's disease, leukemias, and liver or kidney<unk> s,<unk> n<unk> use a persistent fever. Some systemic symptoms of<unk>  are<unk> used by hormones or other molecules produced by the tumor, known as paraneoplastic syndromes. Common paraneoplastic syndromes include hypercalcemia, which<unk> n<unk> use altered mental state, constipation and dehydration, or hyponatremia, which<unk> n also<unk> use altered mental status, vomiting, headaches, or seizures. Metastasis Metastasis is the spread of<unk>  to other locations in the body. The dispersed tumors are<unk> lled metastatic tumors, while the original is<unk> lled the primary tumor. Almost all<unk> s<unk> n metastasize. Most<unk>  deaths are due to<unk>  that has metastasized. Metastasis is common in the late stages of<unk>  and it<unk> n occur via the blood or the lymphatic system or both. The typical steps in metastasis are local invasion, intravasation into the blood or lymph, circulation through the body, extravasation into the new tissue, proliferation and angiogenesis. Different types of<unk> s tend to metastasize to particular organs, but overall the most common places for metastases to occur are the lungs, liver, brain and the bones.
Cancer
Anorexia nervosa
Disease
Heartburn
Cardiovascular disease
Vaginitis
Skin cancer
Neuropathic pain