<unk>  is slowly absorbed from the gastrointestinal tract after oral ingestion. It has a long half-life and therefore a prolonged diuretic action, which results in continued diuretic effects despite a skipped dose. This prolonged action of<unk>  despite missing doses may account for the higher efficacy of<unk>  compared to the shorter half-life medication, hydrochlorothiazide.<unk>  is eliminated from the body mostly by the kidney, as unchanged drug. Thus, in persons with diminished kidney function, the clearance of<unk>  is reduced and the elimination half-life is increased. As with other thiazide diuretics,<unk>  crosses the placenta and is excreted in breast milk.<unk>  may suppress lactation, and has been used for this indication. Due to its long half-life,<unk>  may accumulate in newborns via breast milk, despite receiving only about 6% of the maternal weight-adjusted dose.
Chlortalidone
Primidone
Rimonabant
Thioridazine
Ziprasidone
Domperidone
Methylphenidate
Paliperidone