Adverse effects by incidence include: Common (>1% frequency): * Hypersensitivity reactions (e.g. itchiness, contact dermatitis, and hives) * Myelosuppression * Gastrointestinal effects (e.g. nausea, vomiting, and diarrhoea) * Headache Rare (<1% frequency): * Stevens–Johnson syndrome * Toxic epidermal necrolysis * Agranulocytosis * Aplastic anaemia * Disorder of haematopoietic structure * Drug-induced eosinophilia * Thrombocytopaenia * Liver necrosis * Hepatitis * Jaundice * Hepatomegaly * Nephrotoxicity Unknown frequency: * Weight loss * Abdominal cramps * Hair loss * Photosensitivity * Fatigue * Fever * Polyneuritis * Atrophic glossitis * Gastritis * Abnormal liver function test results (e.g. elevated serum ALT, AST, alkaline phosphatase, and bilirubin concentrations) Contraindications Use of this drug is contraindicated in: * Megaloblastic anaemia caused by folate deficiency * Hypersensitivity to<unk> , sulfonamides, or any ingredient in the formulation * Repeated prophylactic (prolonged) use in patients with kidney or liver failure or blood dyscrasias * Infants <2 months of age * Prophylaxis in pregnancy at term * Prophylaxis in nursing women * Acute porphyria
Sulfadoxine/pyrimethamine
Quinine
Artesunate/mefloquine
Praziquantel
Artesunate/amodiaquine
Doxycycline
Nifurtimox/eflornithine
Albendazole