In mice and rats, the median lethal dose (LD50) of<unk>  is approximately or slightly greater than 1250 mg/kg. Oral LD50 values reported for rats range from 1000 to 3400 mg/kg. Intravenous LD50 for dogs is 300 mg/kg. Clinical trials on humans involving taking up to 1200 mg/day for 7–21 days and known incidents of acute one-time overdoses up to 4500 mg did not appear to cause life-threatening effects, although a number of adverse experiences were observed, including excitation or agitation, insomnia, anxiety, irritability, aggressiveness, confusion, nervousness, tremor, palpitations, sleep disturbances, nausea, and diarrhea. As of 2004, the FDA is not aware of any fatal overdoses involving<unk>  alone (as opposed to multiple drugs including<unk> .
Modafinil
Armodafinil
Methylphenidate
Adrafinil
Dexmethylphenidate
Ethylphenidate
Dimethazan
Fluparoxan