<unk>  occurs due to an imbalance between the normal balance between protein synthesis and protein degradation. This involves complex cell signalling that is incompletely understood and<unk>  is likely the result of multiple contributing mechanisms. Mitochondrial function is crucial to skeletal muscle health and detrimental changes at the level of the mitochondria may contribute to<unk> . A decline in mitochondrial density as well as quality is consistently seen in<unk>  due to disuse. The ATP-dependent ubiquitin/proteasome pathway is one mechanism by which proteins are degraded in muscle. This involves specific proteins being tagged for destruction by a small peptide called ubiquitin which allows recognition by the proteasome to degrade the protein.
Muscle atrophy
Muscle weakness
Muscle hypertrophy
Breast atrophy
Muscle imbalance
Lipoatrophy
Tooth loss
Lumbar enlargement