<unk>  (DAD) or maternally inherited<unk>  (MIDD) or mitochondrial<unk>  is a subtype of<unk>  which is caused from a point mutation at position 3243 in human mitochondrial DNA, which consists of a circular genome. This affects the gene encoding tRNALeu. Because mitochondrial DNA is contributed to the embryo by the oocyte and not by spermatozoa, this disease is inherited from maternal family members only. As indicated by the name, MIDD is characterized by<unk>  and sensorineural hearing loss.
Diabetes and deafness
Epilepsy in children
Hypertension and brachydactyly syndrome
Zonular cataract and nystagmus
Old age and driving
Tubulointerstitial nephritis and uveitis
Chest pain in children
Renal cysts and diabetes syndrome