<unk><unk><unk><unk> brain (MEB) disease, also known as muscular dystrophy-dystroglycanopathy congenital with brain and<unk>  anomalies A3 (MDDGA3), is a kind of rare congenital muscular dystrophy (CMD), largely characterized by hypotonia at birth. Patients suffer from muscular dystrophy, central nervous system abnormalities and ocular abnormalities, the condition is degenerative. MEB is caused by mutations in the POMGnT1 gene, it is congenital and inherited as an autosomal recessive disorder. There is no cure for MEB. Supportive care mainly focuses on symptoms alleviation which varies in different clinical settings. Symptomatic treatment may include physiological therapies, occupational therapies, medications, and surgeries. The life expectancy of patients with MEB is over 70 years old.
Muscle–eye–brain disease
Basal ganglia disease
White dot syndromes
Aging brain
Early myoclonic encephalopathy
Neurolathyrism
Leukodystrophy
Wernicke encephalopathy