<unk> , is a disease classified as intermediate in a spectrum of step-wise progressive diseases termed plasma cell dyscrasias. In this spectrum of diseases, a clone of plasma cells secreting monoclonal paraprotein (also termed<unk>  protein or M protein) causes the relatively benign disease of monoclonal gammopathy of undetermined significance. This clone proliferates and may slowly evolve into more aggressive sub-clones that cause<unk>  multiple<unk> . Further and more rapid evolution causes the overtly malignant stage of multiple<unk>  and can subsequently lead to the extremely malignant stage of secondary plasma cell leukemia. Thus, some patients with<unk>  progress to multiple<unk>  and plasma cell leukemia.<unk> , however, is not a malignant disease. It is characterised as a pre-malignant disease that lacks symptoms but is associated with bone marrow biopsy showing the presence of an abnormal number of clonal<unk>  cells, blood and/or urine containing a<unk>  protein, and a significant risk of developing into a malignant disease.
Smouldering myeloma
Multiple myeloma
Monoclonal gammopathy of undetermined significance
AL amyloidosis
POEMS syndrome
Plasma cell leukemia
Monoclonal gammopathy of renal significance
Secondary systemic amyloidosis