Body weight Numerous reviews have concluded that the association between body weight and non-nutritive sweetener usage is inconclusive. Observational studies tend to show a link to high body weight, while randomized controlled trials instead show a small causal weight loss. Other reviews concluded that use of non-nutritive sweeteners instead of<unk>  reduces body weight. Obesity Two reviews found no clinical evidence to indicate that non-caloric sweeteners cause metabolic syndrome or obesity. Cancer Artificial sweeteners do not cause cancer. Multiple reviews have found no link between artificial sweeteners and the risk of developing cancer.FDA scientists have reviewed scientific data regarding the safety of aspartame and different sweeteners in food and concluded that they are safe for the general population under certain conditions. Mortality High consumption of artificially sweetened beverages was associated with a 12% higher risk of all-cause mortality and a 23% higher risk of CVD mortality in a 2021 meta-analysis. A 2020 meta-analysis found a similar result, with the highest consuming group having a 13% higher risk of all-cause mortality and a 25% higher risk of CVD mortality.<unk>  alcohols<unk>  alcohols, or polyols, are sweetening and bulking ingredients used in manufacturing of foods and beverages. As a<unk> , they supply fewer calories (about a half to one-third fewer calories) than<unk> , are converted to glucose slowly, and do not spike increases in blood glucose. Comparison to<unk>  Reviews and dietetic professionals have concluded that moderate use of non-nutritive sweeteners as a safe replacement for<unk> s can help limit energy intake and assist with managing blood glucose and weight.
Sugar substitute
Salt substitute
Caloric restriction mimetic
Steroid ester
Prebiotic 
Protein supplement
Deodorant
Pharmacological chaperone