The human skin consists of two layers: an outermost layer called the epidermis and a layer underneath called the dermis. In individuals with healthy skin, there are protein anchors between these two layers (Dermo epidermal junction) that prevent them from moving independently from one another (shearing). In people born with<unk> , the two skin layers lack the protein anchors that hold them together, resulting in extremely fragile skin—even minor mechanical friction (like rubbing or pressure) or trauma will separate the layers of the skin and form blisters and painful sores. Sufferers of<unk>  have compared the sores with third-degree burns. Furthermore, as a complication of the chronic skin damage, people suffering from<unk>  have an increased risk of malignancies (cancers) of the skin.
Epidermolysis bullosa
Pemphigus vulgaris
Tinea imbricata
Bullous pemphigoid
Linitis plastica
Diabetic bulla
Ichthyosis bullosa of Siemens
Lichen myxedematosus