Afflicted individuals (median age 76 years; range 49–92 years; more common in females) typically present with one or more rapidly growing red to<unk> luish-red, firm tumors located on the<unk> (s) at some site(s)<unk> elow the knees. Occasionally the lesions are ulcerated. About 10% of cases do not have lesions on the<unk> s<unk> ut rather present with one or more skin lesions outside of the<unk> s; ~20% of individuals present with cutaneous lesion(s)<unk> ut on further or later investigation are found to have disease in non-cutaneous sites such as the lymph nodes, visceral organs,<unk> one marrow, and/or, rarely, central nervous system. Some individuals, particularly those with widespread disease, complain of having the<unk>  symptoms of fever, night sweats, and/or weight loss. DLBCL cases that have cutaneous lesions in association with widespread disease may<unk> e advanced PCDLBCL, LT<unk> ut without evidence that the disease<unk> egan in the skin are diagnosed as having and treated for some other variant or subtype of the<unk>  large<unk> -cell lymphomas that has spread to the skin.
Primary cutaneous diffuse large B-cell lymphoma, leg type
Secondary cutaneous CD30+ large-cell lymphoma
Primary cutaneous marginal zone lymphoma
Primary cutaneous follicle center lymphoma
Primary cutaneous immunocytoma
CD30+ cutaneous T-cell lymphoma
Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma
Chronic multifocal Langerhans cell histiocytosis