The rate of omeprazole absorption is decreased by concomitant food intake. In addition, the absorption of lansoprazole and esomeprazole is decreased and delayed by food. It has been reported, however, that these pharmacokinetic effects have no significant impact on efficacy.<unk> s have a half-life in human blood plasma of only 60–90 minutes, but because they covalently bind to the<unk> , the half-life of their inhibition of gastric acid secretion lasts an estimated 24 hours. Dissociation of the<unk> y complex is probably due to the effect of the endogenous antioxidant glutathione which leads to the release of omeprazole sulfide and reactivation of the enzyme.
Proton-pump inhibitor
Antisialagogue
Mucoactive agent
Prokinetic agent
Galactagogue
Cholagogue
Antacid
Caloric restriction mimetic