In<unk> , the cerebellar cortex loses its normal architecture, and forms a hamartoma in the cerebellar hemispheres. The tumors are usually found on the left cerebellar hemisphere, and consist of abnormal hypertrophic ganglion cells that are somewhat similar to Purkinje cells. The amount of white matter in the cerebellum is diminished. Like cowden syndrome, patients with<unk>  often have mutations in enzymes involved in the Akt/PKB signaling pathway, which plays a role in cell growth. Mutation in PTEN gene on chromosome no. 10q leads to increased activity of AKT and mTOR pathways.
Lhermitte–Duclos disease
Parkes Weber syndrome
Madras motor neuron disease
Charcot–Marie–Tooth disease
Dejerine–Sottas disease
Hereditary spastic paraplegia
Amyotrophic lateral sclerosis
Surfer's myelopathy