<unk> , or hyperostosis corticalis generalisata is an autosomal recessive skeletal disease which is characterised by uninhibited bone growth, especially in the mandible, skull and ribs. The disease was first described in 1955 by Prof. Franciscus Stephanus Petrus<unk><unk> , when describing two patients of the same family in Urk in the Netherlands. The cause, he found, was that the bone was produced faster than the body broke it down, making it much thicker as the patient got older. The first symptoms experienced by the affected were often deafness and paralysis of the face, caused by the growing bone pinching the nerves. This condition can be traced to a deletion on chromosome 17q. As the disease is recessive, a child will only be affected by the disease if both of the parents are carriers and the child is homozygous for the allele, meaning that they have the allele in duplicate. The gene involved is SOST, and by extension the protein involved is sclerostin. There have been attempts to relieve a patient suffering from<unk> : "A large bilateral frontoparietal craniotomy and decompression of the foramen magnum resulted in almost complete relief of his symptoms." __TOC__
Van Buchem disease
Freiberg disease
Hydroa vacciniforme
Keratin disease
Degos disease
Dent's disease
Lichen planus
Keratosis pilaris