<unk> , sold under the brand names Progynon and Emmenin, is an estrogen medication which was previously used for estrogen-type indications such as the treatment of menopausal symptoms in women. The term specifically refers to formulations of estriol<unk>  which were manufactured from the estrogen-rich urine of pregnant women and were used as medications in the 1920s and 1930s.<unk>  is analogous to and was superseded by<unk>  estrogens (brand name Premarin), which is manufactured from the urine of pregnant mares.<unk>  was among the first forms of pharmaceutical estrogen to be used in medicine. It was taken by mouth. The main components of<unk>  are estriol glucuronides and to a lesser extent estriol sulfates. Estrogen glucuronides can be deglucuronidated into the corresponding free estrogens by β-glucuronidase in tissues that express this enzyme, such as the mammary gland, liver, and kidney, among others. Likewise, estrogen sulfates can be desulfated into the corresponding free estrogens by steroid sulfatase in tissues that express this enzyme. Consequently, estrogen<unk>  have estrogenic activity via conversion into unconjugated estrogens.
Conjugated estriol
Estriol glucuronide
Estriol sulfate glucuronide
Polyestriol phosphate
17β-Aminoestrogen
Androgen prohormone
11-Ketoprogesterone
Dehydroepiandrosterone sulfate