Regulatory uses Through the use of the PBT Profiler and using criteria set forth by the United States Environmental Protection Agency under the Toxic Substances Control Act (TSCA), a substance is considered to be not bioaccumulative if it has a BCF less than 1000, bioaccumulative if it has a BCF from 1000 to 5000 and very bioaccumulative if it has a BCF greater than 5,000. The thresholds under REACH are a BCF of > 2000 L/kg bzw. for the B and 5000 L/kg for vB criteria.
Bioconcentration
Countercurrent exchange
Selective reabsorption
Enhanced permeability and retention effect
Isobaric counterdiffusion
Augmented renal clearance
Reabsorption
Solvent drag