<unk>  was tested for drug-drug interactions with 28 drugs and showed binding or interaction with 14 of these drugs. This could reduce their availability and thus effectiveness, wherefore<unk>  has received a boxed warning by the US Food and Drug Administration (FDA), telling patients to wait for at least six hours between taking<unk>  and any other oral drugs. Of the 14 drugs that did show an interaction in vitro, 12 were selected for further testing in phase 1 studies in healthy volunteers to assess whether the results seen in vitro translated into an effect in people. These studies showed<unk>  did not alter the absorption of nine of the 12 drugs when co-administered.<unk>  reduced absorption of three drugs when co-administered, however, there was no interaction when<unk>  and these three drugs were taken 3 hours apart. This information was submitted to the FDA in the form of a supplemental New Drug Application (sNDA) and as a result, in November 2016 the FDA approved the removal of the boxed warning regarding the separation of<unk>  and other oral medications. The updated label recommends patients take<unk>  at least three hours before or three hours after other oral medications.
Patiromer
Sesquimustard
Veristrat
Lepromin
Suvorexant
Seltorexant
Dimethazan
Daridorexant