Some of the common side effects of<unk>  are flu-like symptoms (such as fever, chills and mild pain), nausea and diarrhea. Cardiac toxicity One of the more serious complications of<unk>  is its effect on the heart, although this is rare. In 2-7% of cases,<unk>  is associated with cardiac dysfunction, which includes congestive heart failure. As a result, regular cardiac screening with either a MUGA scan or echocardiography is commonly undertaken during the<unk>  treatment period. The decline in ejection fraction appears to be reversible.<unk>  downregulates neuregulin-1 (NRG-1), which is essential for the activation of cell survival pathways in cardiomyocytes and the maintenance of cardiac function. NRG-1 activates the MAPK pathway and the PI3K/AKT pathway as well as focal adhesion kinases (FAK). These are all significant for the function and structure of cardiomyocytes.<unk>  can therefore lead to cardiac dysfunction. Approximately 10% of people are unable to tolerate the drug because of pre-existing heart problems; physicians are balancing the risk of recurrent cancer against the higher risk of death due to cardiac disease in this population. The risk of cardiomyopathy is increased when<unk>  is combined with anthracycline chemotherapy (which itself is associated with cardiac toxicity). Birth control Women having periods (or whose periods stopped due to chemotherapy) may need to use barrier contraception (such as condoms) while taking<unk> , and for at least six months afterwards. This is because of the possibility of harming a developing fetus.
Trastuzumab
Docetaxel
Tamoxifen
Paclitaxel
Ribociclib
Cetuximab
Palbociclib
N-Desmethyltamoxifen