Differential diagnosis<unk>  Lipo-lymphedema Lymphedema Obesity Venous insufficiency/venous stasis Symptoms: Fat deposits / swelling in legs and arms not in hands or feet; hands and feet may be affected as the disease progresses. Fat deposits / swelling widespread in legs/arms/torso Fat deposits / swelling in one limb including hands and feet Fat deposits widespread Swelling near ankles; brownish discoloration of lower legs (hemosiderin deposits). Minimal swelling possible. Male/female: F F F/M F/M F/M Onset: Around hormonal shifts (puberty, pregnancy, menopause) Around hormonal shifts After surgery that affects lymphatic system, or at birth Any age Around onset of obesity, diabetes, pregnancy, hypertension Effects of diet: Restricting calories ineffective Restricting calories ineffective Restricting calories ineffective Diets and weight loss strategies often effective No relation to caloric intake Presence of edema: Non-pitting edema Much edema; some pitting; some fibrosis Pitting edema No edema Often edema, but can also occur without edema in earlier stages Presence of Stemmer Sign: Stemmer's Sign negative Stemmer's Sign positive Stemmer's Sign positive Stemmer's Sign negative Stemmer's sign may or may not be present in lymphedema/lipolymphedema Presence of pain: Pain in affected areas likely Pain in affected areas No pain initially No pain Pain is likely Affected population: Best estimate is 11% adult women (study done in Germany) Unknown; best estimate is a few percent of adult women Low ≥30% of US adults >30% of US adults Presence of cellulitis: No history of cellulitis Likely history of cellulitis Possible history of cellulitis Often itching +/- discoloration mistaken for cellulitis Family history: Family history likely Family history of<unk>  likely Family history not likely unless primary lymphedema Family history likely Very likely family history<unk>  stages<unk>  is classified by stage: Stage 1: Normal skin surface with enlarged hypodermis<unk>  fat). Stage 2: Uneven skin with indentations in fat and larger hypodermal masses (lipomas). Stage 3: Bulky extrusions of skin and fat cause large deformations especially on the thighs and around the knees. These large extrusions of tissue drastically inhibit mobility. Similar conditions<unk>  is often underdiagnosed due to the difficulty in differentiating it from lymphedema, obesity, or other edemas. Lipo-lymphedema Lipo-lymphedema, a secondary lymphedema, is associated with both<unk>  and obesity (which occur together in the majority of cases), most often<unk>  stages 2 and 3. Dercum's disease<unk>  / Dercum's disease differentiation – these conditions may co-exist. Dercum's disease is a syndrome of painful growths in subcutaneous fat. Unlike<unk> , which occurs primarily in the trunk and legs, the fatty growths can occur anywhere on the body.
Lipedema
Lymphedema
Picardy sweat
Lipohypertrophy
Myxedema
Chronic venous insufficiency
Leukoedema
Phimosis