See the equivalent section in the main migraine article.<unk>  mutations are believed to lead to migraine susceptibility by lowering the threshold for cortical-spreading-depression generation. The<unk> 1 and<unk> 3 mutations occur in ion channels expressed in neurons. These mutations may lead to both the hyper- and hypoexcitable neurons that might underlie cortical-spreading-depression. How the mutations seen in<unk> 2 patients might lead to<unk>  symptoms is even less clear, as the gene mutated in<unk> 2 is expressed primarily in astrocytes. One proposal states that the depolarization of astrocytes caused by haploinsufficiency of the ATP1A2 /-ATPase causes increased release of compounds such as adenosine from astrocytes. These compounds then interact with neighboring neurons, altering their excitability and leading to cortical-spreading-depression and migraine.
Familial hemiplegic migraine
Hemiplegic migraine
Sporadic hemiplegic migraine
Mixed tension migraine
Cluster headache
Acephalgic migraine
Red wine headache
Trigeminal neuralgia