<unk>  generally has a low potential to interact with other pharmaceutical drugs. Combination with other drugs that affect blood clotting, such as aspirin, heparins and thrombolytics, showed no relevant interactions. Naproxen did increase the likelihood of occult gastrointestinal bleeding, as might be the case with other nonsteroidal anti-inflammatory drugs. As<unk>  inhibits the liver enzyme CYP2C19 in cellular models, it has been theorized that it might increase blood plasma levels of drugs that are metabolized by this enzyme, such as phenytoin and tolbutamide. Clinical studies showed that this mechanism is irrelevant for practical purposes. In November 2009, the U.S. Food and Drug Administration (FDA) announced that<unk>  should be used with caution in people using the proton-pump inhibitors omeprazole or esomeprazole, but pantoprazole appears to be safe. The newer antiplatelet agent prasugrel has minimal interaction with , hence might be a better antiplatelet agent (if no other contraindications are present) in people who are on these proton-pump inhibitors.
Clopidogrel
Ticlopidine
Ticagrelor
Prokarin
Apixaban
Rivaroxaban
Warfarin
Heparin