The burning and painful sensations associated with<unk>  result from its chemical interaction with sensory neurons.<unk> , as a member of the vanilloid family, binds to a receptor called the vanilloid receptor subtype 1 (TRPV1). First cloned in 1997, TRPV1 is an ion channel-type receptor. TRPV1, which can also be stimulated with heat, protons and physical abrasion, permits cations to pass through the cell membrane when activated. The resulting depolarization of the neuron stimulates it to signal the brain. By binding to the TRPV1 receptor, the<unk>  molecule produces similar sensations to those of excessive heat or abrasive damage, explaining why the spiciness of<unk>  is described as a burning sensation. Early research showed<unk>  to evoke a long-onset current in comparison to other chemical agonists, suggesting the involvement of a significant rate-limiting factor. Subsequent to this, the TRPV1 ion channel has been shown to be a member of the superfamily of TRP ion channels, and as such is now referred to as . There are a number of different TRP ion channels that have been shown to be sensitive to different ranges of temperature and probably are responsible for the human range of temperature sensation. Thus,<unk>  does not actually cause a chemical burn, or indeed any direct tissue damage at all, when chili peppers are the source of exposure. The inflammation resulting from exposure to<unk>  is believed to be the result of the body's reaction to nerve excitement. For example, the mode of action of<unk>  in inducing bronchoconstriction is thought to involve stimulation of C fibers culminating in the release of neuropeptides. In essence, the body inflames tissues as if it has undergone a burn or abrasion and the resulting inflammation can cause tissue damage in cases of extreme exposure, as is the case for many substances that cause the body to trigger an inflammatory response.<unk>  was instrumental in the 2021 Nobel Prize in Physiology or Medicine, as it had led to the discovery of receptors for temperature and touch.
Capsaicin
Eoxin
Agitoxin
Toxin
Dermatoxin
Toxicophore
Scyllatoxin
Allergen