Mechanism of action<unk>  has high affinity for the α1A adrenergic receptor in the prostate, the bladder, and the prostatic urethra. By this mechanism it relaxes the smooth muscle in these organs, easing urinary flow and other symptoms of BPH. Pharmacokinetics The absolute bioavailability after oral intake is 32%. Food has little effect on the AUC. When in the bloodstream, 96,6% of the substance are bound to blood plasma proteins. Its main metabolite is<unk>  glucuronide, which inhibits the α1A receptor with 1/8 of the affinity of the parent substance. 91% of the glucuronide are bound to plasma proteins. The enzyme mainly responsible for the formation of the glucuronide is UGT2B7. Other enzymes involved in the metabolism are alcohol dehydrogenases, aldehyde dehydrogenases and CYP3A4.<unk>  is almost completely excreted in the form of metabolites; 33.5% via the urine and 54.9% via the feces. The biological half-life of<unk>  is 11 hours on average, and that of the glucuronide is 18 hours or 24 hours. (Sources are contradictory on this.) File:Silodosin glucuronide.Silodosin glucuronide File:Silodosin acid.KMD-3293, the other main metabolite
Silodosin
Terazosin
Erythrocrine
Doxazosin
Tamsulosin
Oxymetazoline
Methylergometrine
Tropicamide