<unk>  in cyclin/CDK pathway<unk>  proteins are cell-cycle inhibitors. When they bind to CDK4 and CDK6, they induce an allosteric change that leads to the formation of CDK-INK4 complexes rather than CDK-cyclin complexes. This leads to an inhibition of retinoblastoma (Rb) phosphorylation downstream. Therefore, the expression of p15INK4b or p16INK4A keeps the Rb-family proteins hypophosphorylated. This allows the hypophosphorylated Rb to repress transcription of S-phase genes causing cell cycle arrest in the G1 phase.
INK4
ERCC2
WRAP53
FCER1
BRCA1
P73
Mad2
CoWIN