IKK-β plays a significant role in brain cells following a stroke. If NF-κB activation by IKK-β is blocked, damaged cells within the brain stay alive, and according to a study performed by the University of Heidelberg and the University of Ulm, the cells even appear to make some recovery. Inhibition of IKK and IKK-related kinases has been investigated as a therapeutic option for the treatment of inflammatory diseases and cancer. The small-molecule inhibitor of<unk>  SAR113945, developed by Sanofi-Aventis, was evaluated in patients with knee osteoarthritis.
IKK2
STAT protein
AP-7 
NLRP3
CDK13
Bcl-2
BBV154
Bcl-xL