Severe<unk>  caused by some drugs can be prevented by using lower doses, infusing slowly, and administering anti-histamines or corticosteroids before and during administration of the drug. In vitro assays have been developed to understand the risk that pre-clinical drug candidates might cause<unk>  and guide dosing for Phase I trials, and regulatory agencies expect to see results of such tests in investigational new drug applications. A modified Chandler loop model can be used as a preclinical tool to assess infusion reactions.
Cytokine release syndrome
Macrophage activation syndrome
Systemic inflammatory response syndrome
Activation syndrome
Mast cell activation syndrome
Multiple organ dysfunction syndrome
SUNCT syndrome
SAHA syndrome