<unk>  is a rare severe adverse reaction to smallpox vaccination. It is characterized by serious local or disseminated, umbilicated, vesicular, crusting skin rashes in the face, neck, chest, abdomen, upper limbs and hands, caused by widespread infection of the skin in people with previous diagnosed skin conditions such as<unk>  or atopic dermatitis,<unk> en if the conditions are not active at the time. Other signs and symptoms include fever and facial and supraglottic edema. The condition may be fatal if severe and left untreated. Survivors are likely to have some scarring (pockmarks). Smallpox vaccine should not be given to patients with a history of<unk> . Because of the danger of transmission of vaccinia, it also should not be given to people in close contact with anyone who has active<unk>  and who has not been vaccinated. People with other skin diseases (such as atopic dermatitis, burns, impetigo, or herpes zoster) also have an increased risk of contracting<unk>  and should not be vaccinated against smallpox.
Eczema vaccinatum
Tinea barbae
Tinea corporis
Tinea faciei
Lichen simplex chronicus
Alopecia mucinosa
Tinea cruris
Lichen scrofulosorum