<unk>  are used in addition to changes in diet to reduce triglyceride levels in adults with severe (≥ 500 mg/dL) hypertriglyceridemia. In the European Union and other major markets outside the US,<unk>  are indicated for hypertriglyceridemia by itself, or in combination with a statin for people with mixed dyslipidemia. Intake of large doses (2.0 to 4.0 g/day) of long-chain<unk> -3 fatty acids as prescription drugs or dietary supplements are generally required to achieve significant (> 15%) lowering of triglycerides, and at those doses the effects can be significant (from 20% to 35% and even up to 45% in individuals with levels greater than 500 mg/dL). It appears that both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) lower triglycerides, but DHA appears to raise LDL-C ("bad cholesterol") more than EPA, while DHA raises HDL-C ("good cholesterol") while EPA does not. Other fish-oil based drugs There are other<unk> -3 fish oil based prescription drugs on the market that have similar uses and mechanisms of action. *<unk>  eicosapentaenoic acid (Vascepa). EPA-only<unk><unk> . *<unk> -3 carboxylic acids (Epanova). This product contains free fatty acids, not<unk><unk> . It is currently withdrawn from the market by the manufacturer (AstraZeneca) and is thus unavailable to patients. AstraZeneca voluntarily discontinued Phase III clinical trials for futility. Dietary supplements There are many fish oil dietary supplements on the market. There appears to be little difference in effect between dietary supplement and prescription forms of<unk> -3 fatty acids as to ability to lower triglycerides, but the<unk> <unk> products work less well when taken on an empty stomach or with a low-fat meal. The ingredients of dietary supplements are not as carefully controlled as prescription products and have not been tested in clinical trials as such drugs have. Prescription<unk> -3 products are more concentrated, requiring fewer softgels for the same daily dose.
Omega-3 acid ethyl esters
Omega-3 fatty acid
Omega-6 fatty acid
Omega-3 carboxylic acids
Fish oil
Fish oil 
Cholic acid
Soybean oil