Mechanism of action Some authors say<unk>  is a "mid-potency" typical antipsychotic. However, unlike most other typical antipsychotics, it has significant potency at the 5HT2A receptor (6.6 nM), which is similar to atypical antipsychotics like clozapine (5.35 nM). The higher likelihood of EPS with<unk> , compared to clozapine, may be due to its high affinity for the D2 receptor. +<unk>  (and metabolite) Site 5-HT1A 2,460 5-HT1B 388 5-HT1D 3,470 5-HT1E 1,400 5-HT2A 6.6 0.5 5-HT2C 13 2 (rat) 5-HT3 190 5-HT5A 780 5-HT6 31 50 5-HT7 88 40 (rat) α1A 31 α1B 53 α2A 151 α2B 108 α2C 80 β1 >10,000 β2 >10,000 M1 120 M2 445 M3 211 M4 1,270 M5 166 D1 54 D2 11 21 D3 19 21 D4 8.4 21 D5 75 H1 2.2–4.9 7.9–25 H2 208 H3 55,000 >100,000 H4 5,050–8,710 6,310 >10,000 58 5,700 16 >10,000 58 Values are Ki (nM). The smaller the value, the more strongly the drug binds to the site. Pharmacokinetics<unk>  is metabolized to amoxapine, as well as its 8-hydroxy metabolite (8-hydroxyloxapine). Amoxapine is further metabolized to its 8-hydroxy metabolite (8-hydroxyamoxapine), which is also found in the blood of people taking<unk> . At steady-state after taking<unk>  by mouth, the relative amounts of<unk>  and its metabolites in the blood is as follows: 8-hydroxyloxapine > 8-hydroxyamoxapine ><unk> . The pharmacokinetics of<unk>  change depending on how it is given. Intramuscular injections of<unk>  lead to higher blood levels and area under the curve of<unk>  than when it is taken by mouth.
Loxapine
Amoxapine
Aripiprazole
Sertraline
Asenapine
Mirtazapine
Perlapine
Trimipramine