<unk>  is used in advanced Parkinson's disease intermittent hypomobility ("off" episodes), where a decreased response to an anti-Parkinson drug such as L-DOPA causes muscle stiffness and loss of muscle control. While<unk>  can be used in combination with L-DOPA, the intention is usually to reduce the L-DOPA dosing, as by this stage the patient often has many of dyskinesias caused by L-DOPA and hypermobility periods. When an episode sets in, the<unk>  is injected subcutaneously or<unk> plied sublingually, and signs subside. It is used an average of three times a day. Some people use portable mini-pumps that continuously infuse them with<unk> , allowing them to stay in the "on" state and using<unk>  as an effective monotherapy.
Apomorphine
Desomorphine
Tripelennamine
Droperidol
Tropisetron
Amfepramone
Benzatropine
Bremazocine