Pneumocystis jirovecii pneumonia<unk>  <unk>  is the medicine most commonly used to prevent Pneumocystis jirovecii pneumonia (PCP) Most people who get PCP have a medical condition that weakens their immune system, like HIV/AIDS, or take medicines (such as corticosteroids) that reduce the body's ability to fight bacterial and viral infections. People with HIV/AIDS are less likely to get PCP today as a result of antiretroviral therapy (ART). However, PCP is still a substantial public health problem. Most of what is scientifically known about PCP and its treatment comes from studying patients with HIV/AIDS. Susceptibility Organisms against which<unk>  can be effective include: * Acinetobacter spp. * Aeromonas hydrophila * Alcaligenes/Achromobacter spp. * Bartonella henselae * Bordetella pertussis (pertussis) * Brucella spp. * Burkholderia cepacia * Burkholderia mallei (glanders) * Burkholderia pseudomallei (melioidosis) * Chlamydia trachomatis (chlamydia) * Chryseobacterium meningosepticum * Citrobacter spp. * Enterobacter spp. * Enterococcus faecalis * Escherichia coli * Haemophilus influenzae * Hafnia alvei * Kingella spp. * Klebsiella granulomatis * Klebsiella pneumoniae * Legionella spp. * Listeria monocytogenes (listeriosis) * Moraxella catarrhalis * Morganella morganii * Mycobacterium tuberculosis (tuberculosis) * Neisseria gonorrhoeae (gonorrhoea) * Neisseria meningitidis (meningococcal disease) * Nocardia spp. * Plesiomonas shigelloides * Pneumocystis jirovecii * Proteus mirabilis * Proteus vulgaris * Providencia rettgeri * Providencia stuartii * Salmonella typhi (typhoid fever) * Non-typhi Salmonella * Serratia spp. * Shigella spp. * Staphylococcus aureus * Staphylococcus epidermidis * Staphylococcus saprophyticus * Stenotrophomonas maltophilia * Streptococcus agalactiae * Streptococcus pneumoniae * Streptococcus pyogenes * Streptococcus viridans * Toxoplasma gondii (toxoplasmosis) * Tropheryma whippelii (Whipple's disease) * Vibrio cholerae (cholera) * Yersinia enterocolitica * Yersinia pestis (bubonic plague) * Yersinia pseudotuberculosis The only notable nonsusceptible organisms are Pseudomonas aeruginosa, the mycoplasmae and Francisella tularensis (the causative organism of tularaemia). Pregnancy and breast feeding Its use during pregnancy is contraindicated, although it has been placed in Australian pregnancy category C. Its use during the first trimester (during organogenesis) and 12 weeks prior to pregnancy has been associated with an increased risk of congenital malformations, especially malformations associated with maternal folic acid deficiency (which is most likely related to the mechanism of action of co-trimoxazole) such as neural tube defects such as spina bifida, cardiovascular malformations (e.g. Ebstein's anomaly), urinary tract defects, oral clefts, and club foot in epidemiological studies. Its use later on during pregnancy also increases the risk of preterm labour (odds ratio: 1.51) and low birth weight (odds ratio: 1.67). Animal studies have yielded similarly discouraging results. It appears to be safe for use during breastfeeding as long as the baby is healthy. Babies Its use in those less than 2 months of age is not recommended due to the risk of adverse side effects.
Trimethoprim/sulfamethoxazole
Doxycycline
Dapsone
Micafungin
Merafloxacin
Teicoplanin
Phenoxymethylpenicillin
Amikacin