Seizures in<unk>  can be difficult to manage but may be reduced by anticonvulsant medications such as clobazam, stiripentol, topiramate and valproate. Because the course of the disorder varies from individual to individual, treatment protocols may vary. A diet high in fats and low in carbohydrates may also be beneficial, known as a ketogenic diet. Although diet adjustment can help, it does not eliminate the symptoms. Until a better form of treatment or cure is discovered, those with this disease will have myoclonic epilepsy for the rest of their lives. Certain anticonvulsant medications that are classed as sodium channel blockers are now known to make seizures worse in most<unk>  patients. These medications include carbamazepine, gabapentin, lamotrigine, and phenytoin. Treatments include cognitive rehabilitation through psychomotor and speech therapy. In addition, valproate is often administered to prevent recurrence of febrile seizures and a benzodiazepine is used for long lasting seizures, but these treatments are usually insufficient. Stiripentol was the only medication for which a double-blind placebo-controlled randomized controlled trial was performed and this medication showed efficacy in trials. It acts as a GABAergic agent and as a positive allosteric modulator of GABAA receptor. Stiripentol, can improve focal refractory epilepsy, as well as<unk> 's syndrome, supplemented with clobazam and valproate was approved in Europe in 2007 as a therapy for<unk>  and has been found to reduce overall seizure rate by 70%. In cases with more drug-resistant seizures, topiramate and the ketogenic diet are used as alternative treatments. Cannabidiol (CBD) was approved in United States for treatment of<unk>  in 2018. A 2017 study showed that the frequency of seizures per month decreased from 12 to 6 with the use of cannabidiol, compared with a decrease from 15 to 14 with placebo. In 2020, fenfluramine was approved for the medical treatment in the European Union and the USA.
Dravet syndrome
Stratton Parker syndrome
De Barsy syndrome
Rett syndrome
Shapiro syndrome
Catel–Manzke syndrome
Benedikt syndrome
Huntington's disease-like syndrome