Typically, initial signs and symptoms of this disorder occur during infancy or early childhood and can include poor appetite, vomiting, diarrhea, lethargy, hypoglycemia, hypotonia, liver problems, and hyperinsulinism (high levels of insulin). Insulin controls the amount of sugar that moves from the blood into cells for conversion to energy. Individuals with<unk>  are also at risk for complications such as seizures, life-threatening heart and breathing problems, coma, and sudden unexpected death. Problems related to<unk>  can be triggered by periods of fasting or by illnesses such as viral infections. This disorder is sometimes mistaken for Reye syndrome, a severe disorder that may develop in children while they appear to be recovering from viral infections such as chicken pox or flu. Most cases of Reye syndrome are associated with the use of aspirin during these viral infections.
3-hydroxyacyl-coenzyme A dehydrogenase deficiency
3-Methylcrotonyl-CoA carboxylase deficiency
2-Methylbutyryl-CoA dehydrogenase deficiency
3-Hydroxyisobutyryl-CoA deacylase deficiency
Glutaminase deficiency
Pyruvate kinase deficiency
Malonyl-CoA decarboxylase deficiency
Succinyl-CoA:3-oxoacid CoA transferase deficiency