<unk>  combines high tracer sensitivity with submillimeter resolution. Imaging is performed in a range of milliseconds to seconds. The iron oxide tracer used with MPI are cleared naturally by the body through the mononuclear phagocyte system. The iron oxide nanoparticles are broken down in the liver, where the iron is stored and used to produce hemoglobin. SPIOs have previously been used in humans for iron supplementation and liver imaging. Blood pool imaging Cardiovascular The first in vivo MPI results provided images of a beating mouse heart in 2009. With further research, this could eventually be used for real-time cardiac imaging. Oncology MPI has numerous applications to the field of oncology research. Accumulation of a tracer within solid tumors can occur through the enhanced permeability and retention effect. This has been successfully used to detect tumor sites within rats. The high sensitivity of the technique means it may also be possible to image micro-metastasis through the development of nanoparticles targeted to cancer cells. MPI is being investigated as a clinical alternative screening technique to nuclear medicine in order to reduce radiation exposure in at-risk populations. Cell tracking By tagging therapeutic cells with iron oxide nanoparticles, MPI allows them to tracked throughout the body. This has applications in regenerative medicine and cancer immunotherapy. Imaging can be used to improve the success of stem cell therapy by following the movement of these cells in the body. The tracer is stable while tagged to a cell and remains detectable past 87 days. Functional brain imaging MPI has been proposed as a promising platform for functional brain imaging which requires highly sensitive imaging as well as short scan times for sufficient temporal resolution. For this, MPI is used to detect the increase of cerebral blood volume (CBV) arising from neuroactivation. Functional neuroimaging using MPI has been successfully demonstrated in rodents and has a promising sensitivity advantage compared to other imaging modalities. In the long perspective, this could potentially allow to study functional neuroactivation on a single-patient level and thus bring functional neuroimaging to clinical diagnostics.
Magnetic particle imaging
Molecular imaging
Radiochemistry
Radiomics
Neutron imaging
Imaging biomarker
Indium-111 WBC scan
Whole body imaging