DXM/quinidine is used in the treatment of PBA. In a 12-week randomized, double-blind trial, amyotrophic lateral sclerosis and multiple sclerosis patients with significant PBA were given either Nuedexta 20/10 mg or placebo. In 326 randomized patients, the PBA-episode daily rate was 46.9% (p < 0.0001) lower for Nuedexta than for placebo. The three deaths in each of the two drug treatment arms and the single death in the placebo arm of the study were believed to be due to the natural course of the disease.
Dextromethorphan/quinidine
Fentanyl/fluanisone
Bupivacaine/meloxicam
Oxycodone/naloxone
Desloratadine/pseudoephedrine
Pseudoephedrine/loratadine
Phenylephrine/ketorolac
Buprenorphine/naloxone