The sarcomeres become misaligned and result in the disorganization of muscle fibers. This mutation also results in muscle cell death by apoptosis and necrosis. The muscle cell may also be disorganized because the aggregates may interrupt other filament structures and/or normal cellular function.<unk> opathies are very rare diseases and only 60 patients have been diagnosed, however this number probably does not accurately represent the population due to frequent mis or under diagnosis.
Desmin-related myofibrillar myopathy
Hereditary inclusion body myopathy
X-linked myotubular myopathy
Statin-associated autoimmune myopathy
Centronuclear myopathy
LMNA-related congenital muscular dystrophy
Acquired non-inflammatory myopathy
Nemaline myopathy