Currently, purine replacement via S-adenosylmethionine (SAM) supplementation in people with<unk>  appears to improve their condition. This suggests that SAM supplementation can alleviate symptoms of PRPS1 deficient patients by replacing purine nucleotides and open new avenues of therapeutic intervention. Other non-clinical treatment options include educational programs tailored to their individual needs. Sensorineural hearing loss has been treated with cochlear implantation with good results. Ataxia and visual impairment from optic atrophy are treated in a routine manner. Routine immunizations against common childhood infections and annual influenza immunization can also help prevent any secondary infections from occurring. Regular neuropsychological, audiologic, and ophthalmologic examinations are also recommended. Carrier testing for at-risk relatives and prenatal testing for pregnancies at increased risk are possible if the disease-causing mutation in the family is known.
Arts syndrome
Saal Greenstein syndrome
Crandall syndrome
Havana syndrome
Mietens syndrome
PAPA syndrome
Currarino syndrome
Bruck syndrome