Due to its considerable toxicity, use of oleander or its constituents, such as<unk> , is regarded as unsafe and potentially lethal. Use of oleander may cause contact dermatitis, headache, nausea, lethargy, and high blood levels of potassium, with symptoms appearing within a few hours of ingestion. In one fatality, the blood concentration of<unk>  and a related cardiac glycoside from the oleander plant was estimated at 20 ng/ml. In practice, there have been adult cases wherein 14–20 oleander leaves (of unknown<unk>  concentration) proved not to be fatal, but also a lethal case of a child that consumed only one leaf. Symptoms Symptoms of<unk>  poisoning can cause both gastrointestinal and cardiac effects. The gastrointestinal effects can consist of nausea, abdominal pain, and vomiting, as well as higher salivation and diarrhea (which may contain blood). After these first symptoms, the heart may be affected by tachyarrhythmia, bradyarrhythmia, premature ventricular contractions, or atrioventricular blockage. Also, xanthopsia (yellow vision), a burning sensation of the mucous membranes of the eyes, and gastrointestinal tract and respiratory paralysis can occur. Reactions to poisonings from this plant can also affect the central nervous system. These symptoms can include drowsiness, tremors, or shaking of the muscles, seizures, collapse, and even coma that can lead to death. Oleander sap can cause skin irritations, severe eye inflammation and irritation, and allergy reactions characterized by dermatitis when administered topically. Diagnosis Diagnosis of<unk>  poisoning is mainly based on description of the plant, how much of it was ingested, time since ingestion, and symptoms. Three methods are used for detecting<unk>  in the blood. Fluorescence polarization immunoassay is widely used. This test is slower and has a lower sensitivity than digoxin immunoassay (Digoxin III). A direct analytic technique like liquid chromatography-electrospray tandem mass spectrometry is used when there are medical or legal issues.
Oleandrin
Protollin
Tolbutamide
Androstanolone enanthate
Ingenol mebutate
Androstanolone valerate
Androstanolone propionate
Nandrolone phenylpropionate