<unk> agonists competitively and reversibly bind to GnRH receptors in the pituitary gland, blocking the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary. In men, the reduction in LH subsequently leads to rapid suppression of testosterone production in the testes; in women it leads to suppression of estradiol and progesterone production from the ovaries.<unk> agonists are able to abolish gonadal sex hormone production and to suppress sex hormone levels into the castrate range, or by approximately 95%. Unlike the GnRH agonists, which cause an initial stimulation of the hypothalamic–pituitary–gonadal axis (HPG axis) that leads to a surge in testosterone or estrogen levels,<unk> agonists have an immediate onset of action and rapidly reduce sex hormone levels without an initial surge.
Gonadotropin-releasing hormone antagonist
Gonadotropin-releasing hormone agonist
Gonadotropin-releasing hormone modulator
Prolactin modulator
Antiandrogen
Steroidogenesis inhibitor
Thyroid blocker
17α-Alkylated anabolic steroid