<unk>  is a<unk>  molecule which has the<unk> -hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such; it acts to competitively inhibit the production of<unk> -6-phosphate from<unk>  at the phosphoglucoisomerase level (step<unk>  of glycolysis).<unk><unk><unk>  labeled with tritium or carbon-14 has been a popular ligand for laboratory research in animal models, where distribution is assessed by tissue-slicing followed by autoradiography, sometimes in tandem with either conventional or electron microscopy.<unk> -DG is up taken by the<unk>  transporters of the cell. Therefore, cells with higher<unk>  uptake, for example tumor cells, have also a higher uptake of<unk> -DG. Since<unk> -DG hampers cell growth, its use as a tumor therapeutic has been suggested, and in fact,<unk> -DG is in clinical trials. It is not completely clear how<unk> -DG inhibits cell growth. The fact that glycolysis is inhibited by<unk> -DG, seems not to be sufficient to explain why<unk> -DG treated cells stop growing. Because of its structural similarity to mannose,<unk>  has the potential to inhibit N-glycosylation in mammalian cells and other systems, and as such induces ER stress and the Unfolded Protein Response (UPR) pathway.
2-Deoxy-D-glucose
Uridine triacetate
Glycogen
Inositol
Fructosamine
Glabrene
Glucosamine
Glucose