NSAIDs Patients taking Anticoagulants As NSAIDs inhibit cyclooxygenase, the production of thromboxane, a natural coagulator, is inhibited. Therefore, the risk of bleeding during the use of NSAIDs is intensified by concomitant use of anticoagulants. Patients with Chronic Renal Diseases As NSAIDs reduce blood flow to kidney by inhibiting<unk>  synthesis, it leads to renal ischemia and a decrease in glomerular filtration pressure. As a result, the kidney functions of patients with chronic renal diseases is further worsen. Glucocorticoids Patients with Systemic Fungal Infections Glucocorticoids reduces the number of healthy neutrophils in human body, leading to neutropenia. Neutropenia reduces the efficacy of antifungal drugs. Studies show that neutropenia together with high cumulative glucocorticoid concentration in circulation reduce the efficacy of invasive fungal infection treatment. Therefore, patients with fungal infections are not recommended with the use of glucocorticoids. Patients with Diabetes Mellitus Glucocorticoids raise blood glucose level via different mechanisms. They can stimulate endogenous glucose production by activating the genes involved; reduce glucose uptake by muscle and adipose tissue; induce muscle and adipose tissues to produce substrates involved in glucose production and inhibit the section and production of insulin in pancreatic β cells. All these raise blood glucose level and exacerbate diabetes mellitus. Thus, the use of glucocorticoids should be minimized or avoided for diabetes patients.
Prostaglandin inhibitors
Lipase inhibitors
COX-2 inhibitor
Nonsteroidal anti-inflammatory drug
Antiandrogen
Proton-pump inhibitor
Antiplatelet drug
Thyroid blocker