Although<unk>  may be suspected from the appearance of lesions and the patient's risk factors, a definite diagnosis can be made only by biopsy and microscopic examination. Detection of the<unk> HV protein LANA in tumor cells confirms the diagnosis. In differential diagnosis, arteriovenous malformations, pyogenic granuloma and other vascular proliferations can be microscopically confused with<unk> . Differential diagnosis of<unk>  Source: # Naevus # Histiocytoma # Cryptococcosis # Histoplasmosis # Leishmaniasis # Pneumocystis lesions # Dermatophytosis # Angioma # Bacillary angiomatosis # Pyogenic granuloma # Melanoma Classification HHV-8 is responsible for all varieties of<unk> . Since Moritz<unk>  first described the cancer, the disease has been reported in five separate clinical settings, with different presentations, epidemiology, and prognoses. All of the forms are infected with<unk> HV and are different manifestations of the same disease but have differences in clinical aggressiveness, prognosis, and treatment. * Classic<unk><unk>  most commonly appears early on the toes and soles as reddish, violaceous, or bluish-black macules and patches that spread and coalesce to form nodules or plaques. A small percentage of these patients may have visceral lesions. In most cases the treatment involves surgical removal of the lesion. The condition tends to be indolent and chronic, affecting elderly men from the Mediterranean region, Arabian countries or of Eastern European descent. Israel has a higher rate of<unk> HV/HHV-8 infection than Europe. * Endemic<unk> , which has two types. Although this may be present worldwide, it has been originally described later in young African people, mainly from sub-Saharan Africa. This variant is not related to HIV infection and is a more aggressive disease that infiltrates the skin extensively. * African lymphadenopathic<unk><unk>  is aggressive, occurring in children under 10 years of age, presenting with lymph node involvement, with or without skin lesions. * African cutaneous<unk><unk>  presents with nodular, infiltrative, vascular masses on the extremities, mostly in men between the ages of 20 and 50, and is endemic in tropical Africa. * Immunosuppression-associated<unk><unk>  had been described, but only rarely until the advent of calcineurin inhibitors (such as ciclosporines, which are inhibitors of T-cell function) for transplant patients in the 1980s, when its incidence grew rapidly. The tumor arises either when an HHV 8-infected organ is transplanted into someone who has not been exposed to the virus or when the transplant recipient already harbors pre-existing HHV 8 infection. Unlike classic<unk><unk> , the site of presentation is more variable. * AIDS-associated<unk><unk>  typically presents with cutaneous lesions that begin as one or several red to purple-red macules, rapidly progressing to papules, nodules, and plaques, with a predilection for the head, back, neck, trunk, and mucous membranes. In more advanced cases, lesions can be found in the stomach and intestines, the lymph nodes, and the lungs. Compared to other forms of<unk> ,<unk> -AIDS stimulated more interest in<unk>  research, as it was one of the first illnesses associated with AIDS and first described in 1981. This form of<unk>  is over 300 times more common in AIDS patients than in renal transplant recipients. In this case, HHV 8 is sexually transmitted among people also at risk for sexually transmitted HIV infection.
Kaposi's sarcoma
Melanoma
Mule spinners' cancer
Melanocytic nevus
Ewing's sarcoma
Blue rubber bleb nevus syndrome
Lymphangiosarcoma
Pyogenic granuloma