* Physical agents such as heat or radiation can<unk>  a<unk>  by literally cooking or coagulating their contents. * Impaired nutrient supply, such as lack of oxygen or glucose, or impaired production of adenosine triphosphate (ATP) may deprive the<unk>  of essential materials needed to survive. *Metabolic: Hypoxia and Ischemia *Chemical Agents *Microbial Agents:-Virus & Bacteria *Immunologic Agents: Allergy and autoimmune diseases such as Parkinson's and Alzheimer's disease. *Genetic factors: Such as Down's syndrome and sickle<unk>  anemia
Cell damage
Cell death
Growth inhibition
Electrolyte imbalance
Viral interference
Bone decalcification
Tissue expansion
Tissue stress