Cyanosis from<unk>  Resolved after<unk> lene blue<unk>  can be treated with supplemental oxygen and<unk> lene blue.<unk> lene blue is given as a 1% solution (10 mg/ml) 1 to 2 mg/kg administered intravenously slowly over five minutes. Although the response is usually rapid, the dose may be repeated in one hour if the level of<unk> moglobin is still high one hour after the initial infusion.<unk> lene blue inhibits monoamine oxidase, and serotonin toxicity can occur if taken with an SSRI (selective serotonin reuptake inhibitor) medicine.<unk> lene blue restores the iron in hemoglobin to its normal (reduced) oxygen-carrying state. This is achieved by providing an artificial electron acceptor (such as<unk> lene blue or flavin) for NADPH<unk> moglobin reductase (RBCs usually don't have one; the presence of<unk> lene blue allows the enzyme to function at 5× normal levels). The NADPH is generated via the hexose monophosphate shunt. Genetically induced chronic low-level<unk>  may be treated with oral<unk> lene blue daily. Also, vitamin C can occasionally reduce cyanosis associated with chronic<unk> , and may be helpful in settings in which<unk> lene blue is unavailable or contraindicated (e.g., in an individual with G6PD deficiency). Diaphorase (cytochrome b5 reductase) normally contributes only a small percentage of the red blood cell's reducing capacity, but can be pharmacologically activated by exogenous cofactors (such as<unk> lene blue) to five times its normal level of activity.
Methemoglobinemia
Argyria
Sulfhemoglobinemia
Heart failure
Hyperaemia
Hypoxemia
Organic acidemia
Hypercapnia