<unk>  primarily contributes to catecholamine and trace amine biosynthesis. It also participates in the metabolism of xenobiotics related to these substances; for example, the human<unk>  enzyme catalyzes the<unk> -hydroxylation of amphetamine and para-hydroxyamphetamine, producing norephedrine and para-hydroxynorephedrine respectively.<unk>  has been implicated as correlating factor in conditions associated with decision making and addictive drugs, e.g., alcoholism and smoking, attention deficit hyperactivity disorder, schizophrenia, and Alzheimer's disease. Inadequate<unk>  is called<unk>  deficiency. The proximal promoter SNPs rs1989787 and rs1611115 were found to be associated with cognition in Schizophrenia subjects. Further these SNPs (rs1989787;rs1611115) and a distal promoter variant 19bp Ins/Del(rs141116007) were associated with scores of Abnormal Involuntary Movement Scale in Tardive dyskinesia positive schizophrenia subjects. Of the three variants, the proximal promoter SNP(rs1611115) was associated with Positive and Negative Syndrome Scale(PANSS) scores in Tardive dyskinesia positive schizophrenia subjects.
Dopamine beta-hydroxylase
Tyrosine hydroxylase
Catechol-O-methyltransferase
Aromatic L-amino acid decarboxylase
Phenylalanine hydroxylase
Monoamine oxidase B
Monoamine oxidase
Monoamine oxidase A