The muscle fibers are rarely necrotic but have evidence of<unk> <unk> c activity and exocytosis of the phagocytosed material. They have increased variation in size and are predominantly composed of round small and hypertrophic fibers. The vacuoles are strongly reactive for dystrophin and lysosome associated membrane protein 2 (LAMP2). Membrane bound vacuoles and balls of dense material under the basal lamina are present. Deposition of the C5b-9 complement attack complex, subsarcolemmal deposition of calcium and expression of MHC1 complex also occur. On electron microscopy characteristic balls of dense material are commonly seen. The vacuoles may contain remains of mitochondria, membrane whorls and calcium apatite crystals.
Myopathy, X-linked, with excessive autophagy
Sporadic late-onset nemaline myopathy
Desmin-related myofibrillar myopathy
Variably protease-sensitive prionopathy
Frontotemporal dementia and parkinsonism linked to chromosome 17
Familial encephalopathy with neuroserpin inclusion bodies
Pantothenate kinase-associated neurodegeneration
Hereditary motor and sensory neuropathy with proximal dominance