<unk>  plays a significant role in normal basal transcription, transcription coupled repair (TCR), and nucleotide excision repair (NER). Purified<unk>  has been shown to unwind DNA with 3’-5’ polarity. The function of the<unk> (ERCC3) protein in NER is to assist in unwinding the DNA double helix after damage is initially recognized. NER is a multi-step pathway that removes a wide range of different DNA damages that distort normal base pairing. Such damages include bulky chemical adducts, UV-induced pyrimidine dimers, and several forms of oxidative damage. Mutations in the<unk> (ERCC3) gene can lead, in humans, to xeroderma pigmentosum (XP) or XP combined with Cockayne syndrome (XPCS). Mutant<unk>  cells from individuals with the XPCS phenotype are sensitive to UV irradiation and acute oxidative stress.
XPB
ZF2001
ACDC 
SmeT
BBV154
ReNu
TOL101
DEBRA