This disorder usually appears within the first year of life. The signs and symptoms of HMG-CoA<unk>  deficiency include vomiting, dehydration, lethargy, convulsions, and coma. When episodes occur in an infant or child, blood sugar becomes extremely low (hypoglycemia), and harmful compounds can build up and cause the blood to become too acidic (metabolic acidosis). These episodes are often triggered by an infection, fasting, strenuous exercise, or sometimes other types of stress.
3-Hydroxy-3-methylglutaryl-CoA lyase deficiency
3-Methylcrotonyl-CoA carboxylase deficiency
3-Hydroxyisobutyryl-CoA deacylase deficiency
2,4 Dienoyl-CoA reductase deficiency
Pyruvate kinase deficiency
Pyruvate carboxylase deficiency
2-Methylbutyryl-CoA dehydrogenase deficiency
Malonyl-CoA decarboxylase deficiency