<unk>  does not have an exact mechanism. The underlying pathophysiology of acute myeloid leukemia consist of maturational arrest of the bone marrow cell during the early stages of development. A myeloblast is an immature precursor cell that will change into a monocyte, healthy white blood cell. In AML, Myeloblast do not mature but grow and multiply with regulation. The abnormal cells build up in the bone marrow and prevent the development of other healthy cells. This type of arrest is still under study but in most cases, a gene inactivation or activation has occurred due to chromosome translocations or inversion. AML-M4 with an inversion of chromosome 16 is caused by breakage and rearrangement within itself.
Acute myelomonocytic leukemia
Prolymphocytic leukemia
Acute myeloblastic leukemia with maturation
Myeloid leukemia
Acute monocytic leukemia
Mixed-phenotype acute leukemia
Acute megakaryoblastic leukemia
Chronic myelomonocytic leukemia