In pharmacology,<unk>  (ARC) is a phenomenon where certain critically ill patients may display increased<unk>  of a medication through the kidneys. In many cases, it is observed as a measured creatinine<unk>  above that which is expected given the patient's age, gender, and other factors. The phenomenon is most commonly observed in patients with neurologic damage, sepsis, major trauma, or burns.<unk>  can be caused by increased fluid administration, certain medications, and critical illnesses. It can lead to failure of treatment in people due to a decrease in drug concentrations, increase in<unk> , or shorter half life. Many medications require adjustment to account for the changed<unk>  in people with ARC, notably some antibiotics.
Augmented renal clearance
Enhanced permeability and retention effect
Bioconcentration
Electrolyte exclusion effect
Natriuresis
Renal compensation
Prostatic congestion
Adrenal fatigue