Absorption:<unk>  can be administered intravenously and intramuscularly, and the drug is completely absorbed. It is not available orally. Distribution:<unk>  penetrates tissues and body fluids well, including cerebrospinal fluid to treat central nervous system infections.<unk>  is reversibly bound to human plasma proteins and the binding of<unk>  decreases with increasing concentration from a value of 95% at plasma concentrations less than 25 mcg/mL to 85% at plasma concentration of 300 mcg/mL. Over a 0.15 to 3 g dose range in healthy adult subjects, the apparent volume of distribution ranged from 5.8 to 13.5 L. Metabolism: 33–67% of<unk>  is renally excreted as unchanged drug, but no dose adjustments are required in renal impairment with dosages up to 2 grams per day. The rest is excreted in the bile as inactive compounds from hepatic and gut flora metabolism. Elimination: The average elimination half-life in healthy adults is 5.8–8.7 hours. In people with renal impairment, the average elimination half-life increases to 11.4–15.7 hours.
Ceftriaxone
Meropenem
Levofloxacin
Cefotaxime
Azithromycin
Cefepime
Vancomycin
Ampicillin