Side effects of<unk>  can be divided into acute (those occurring while receiving chemotherapy) and delayed (those occurring months to years after completion of chemotherapy). Delayed side effects have assumed particular importance because many patients treated for Hodgkin lymphoma are cured and can expect long lives after completion of chemotherapy. Acute side effects * Hair loss, or alopecia, is a fairly common but not universal side effect of<unk> . Hair that is lost returns in the months after completion of chemotherapy. * Nausea and vomiting can occur with<unk> , although treatments for chemotherapy-induced nausea and vomiting have improved substantially (see Supportive care below). * Low blood counts, or myelosuppression, occur about 50% of the time with<unk> . Blood cell growth factors are sometimes used to prevent this (see Supportive care below). Blood counts are checked frequently while receiving chemotherapy. Any fever or sign of infection that develops needs to be promptly evaluated; severe infections can develop rapidly in a person with a low white blood cell count due to chemotherapy. * Allergic reactions to bleomycin can occur. A small test dose of bleomycin is often given prior to the first round of<unk>  to screen for patients who may be allergic. * Neuropathy: Chemotherapy-induced peripheral neuropathy, a progressive and enduring tingling numbness, intense pain, and hypersensitivity to cold, beginning in the hands and feet and sometimes involving the arms and legs. Delayed side effects * Infertility is probably infrequent with<unk> . Several studies have suggested that, while sperm counts in men decrease during chemotherapy, they return to normal after completion of<unk> . In women, follicle-stimulating hormone levels remained normal while receiving<unk> , suggesting preserved ovarian function. Regardless of these data, fertility options (e.g. semen cryopreservation, oocyte cryopreservation, embryo cryopreservation) should be discussed with an oncologist before beginning<unk>  therapy. * Pulmonary toxicity, or lung damage, can occur with the use of bleomycin in<unk> , especially when radiation therapy to the chest is also given as part of the treatment for Hodgkin lymphoma. This toxicity develops months to years after completing chemotherapy, and usually manifests as cough and shortness of breath. High concentrations of oxygen, such as those often used in surgery, can trigger lung damage in patients who have received bleomycin, even years later. Pulmonary function tests are often used to assess for bleomycin-related damage to the lungs. One study found bleomycin lung damage in 18% of patients receiving<unk>  for Hodgkin disease. Retrospective analyses have questioned whether bleomycin is necessary at all; however, at this point it remains a standard part of<unk> . * Cardiac toxicity, or cardiomyopathy, can be a late side effect of adriamycin. The occurrence of adriamycin-related cardiac toxicity is related to the total lifetime dose of adriamycin, and increases sharply in people who receive a cumulative dose of more than 400 mg/m2. Almost all patients treated with<unk>  receive less than this dose (for 6 cycles of<unk> , the cumulative adriamycin dose is 300 mg/m2); therefore, adriamycin-related cardiac toxicity is very uncommon with<unk> . * Secondary malignancies. Patients cured of Hodgkin lymphoma remain at increased risk of developing other (secondary) cancers. Treatment-related leukemias are uncommon with<unk> , especially as compared with MOPP. However, one study found a risk of second cancers as high as 28% at 25 years after treatment for Hodgkin lymphoma, although most of the patients in this study were treated with MOPP chemotherapy rather than<unk> . Many of these second cancers were lung cancers or, in women, breast cancers, emphasizing the importance of smoking cessation and regular preventive care after completion of treatment. Radiation and chemotherapy probably both play a role in the development of these secondary malignancies; the exact contribution of chemotherapy such as<unk>  can be difficult to tease out.
ABVD
CAREN
SWAP-200
PAIR 
SBAR
PVSRIPO
Birmingham gauge
Sampaolesi line