Although generally well tolerated and numerous advantages over other antidepressants,<unk> s are not devoid of adverse effects. The adverse effects of<unk> s are usually predictable from a knowledge of their pharmacology and are dose related. Such adverse effects are gastrointestinal dysfunction (nausea, diarrhea, epigastric discomfort), effects on the central nervous system (CNS) (anxiety, fatigue, tremor), anticholinergic effects (dry mouth, blurred vision, drowsiness, difficulty in urination) and sexual dysfunction (anorgasmia, low to no libido, erectile dysfunction, numb genitals, retrograde ejaculation, loss of erotic dreams or delayed ejaculation). Occasionally symptoms of sexual dysfunction persist after discontinuation of<unk> s.<unk> s adverse effects are generally mild and temporary and are more of a discomfort than a serious threat in terms of systemic toxicity. Therefore, the adverse effect profile of the<unk> s may offer certain therapeutic advantages in the management of depression.
Development and discovery of SSRI drugs
Suicide prevention
Recovered-memory therapy
Chronic fatigue syndrome treatment
Drug rehabilitation
Alternative therapies for developmental and learning disabilities
Experimental cancer treatment
Alternative cancer treatments