<unk>  has an oral bioavailability of about 90%. Peak plasma concentrations (Cmax) are reached eight to 12 hours after oral administration. It is one of the longest-acting barbiturates available – it remains in the body for a very long time (half-life of two to seven days) and has very low protein binding (20 to 45%).<unk>  is metabolized by the liver, mainly through hydroxylation and glucuronidation, and induces many isozymes of the cytochrome P450 system. Cytochrome P450 2B6 (CYP2B6) is specifically induced by<unk>  via the CAR/RXR nuclear receptor heterodimer. It is excreted primarily by the kidneys.
Phenobarbital
Methylphenobarbital
Phenytoin
Amobarbital
Heptobarbital
Mephenytoin
Galantamine
Levetiracetam