<unk>  has a number of adverse effects including headache, fatigue, gastrointestinal problems such as nausea, vomiting, diarrhea and constipation, muscle and joint pain, rash and other skin conditions, flu-like symptoms, and reduced blood cell count. Less typical side effects are those of the cardiovascular system, such as high blood pressure, various types of arrhythmia, and prolonged QT interval.<unk>  can also affect the body's electrolyte and glucose balance. Though lung-related adverse effects are rare when compared with imatinib and dasatinib, there is a case report of acute respiratory failure from diffuse alveolar hemorrhage in a people taking<unk> .<unk>  carries a black box warning in the United States for possible heart complications. Contraindications include long QT syndrome, hypokalaemia, hypomagnesaemia, pregnancy, planned pregnancy, lactation and galactose/lactose intolerance. Cautions include: * Myelosuppression * Tumour lysis syndrome * Liver impairment * History of pancreatitis * Check serum lipase periodically in order to detect pancreatitis * Total gastrectomy * Avoid pregnancy or impregnating women Dose reduction has been recommended in people with liver problems which involves recommendation of lower starting dose and monitoring of any hepatic function abnormalities. Hepatitis B virus reactivation may also occur.
Nilotinib
Icotinib
Crizotinib
Tepotinib
Afatinib
Erlotinib
Axitinib
Imatinib