The principal action of<unk>  is reported to be inhibition of aromatase activity and the reduction in estrogen synthesis that follows. Androstenedione, a 19-carbon steroid hormone produced in the adrenal glands and the gonads, is where estrone synthesis originates and is the source of estrogen in postmenopausal women. In vitro studies report that the aromatase inhibition may be noncompetitive and irreversible, and could possibly account for the persistence of this drug's effect on estrogen synthesis after drug withdrawal.<unk>  at a dosage of 1,000 mg/day has been found to decrease estradiol levels in men by 25 to 50% after 6 to 10 days of use. This reduction is substantially less than with second- and third-generation aromatase inhibitors. In addition to its activity as an aromatase inhibitor,<unk>  also reportedly possesses some anabolic activity and weak androgenic activity via binding to and activation of the androgen receptor (AR). However, its affinity for the AR is very low; in one study, it showed 0.0029% of the affinity of the anabolic steroid metribolone (100%) for the human AR (Ki = 41 μM and 1.18 nM, respectively). In accordance, androgenic side effects such as hirsutism, acne, and voice changes have been reported in no women in clinical trials with<unk> .
Testolactone
Menotropin
Dehydroepiandrosterone
Dehydroepiandrosterone sulfate
Prolene
Luteinizing hormone
Progonadotropin
Allyltestosterone