The cause is unknown. However, there are several theories of causation.<unk>  floor dysfunction One theory is that<unk>  is a psychoneuromuscular (psychological, neurological, and muscular) disorder. The theory proposes that anxiety or stress results in<unk> , unconscious contraction of the<unk>  floor muscles, leading to the formation of trigger points and<unk> . The<unk>  results in further anxiety and thus worsening of the condition. Nerves, stress and hormones Another proposal is that it may result from an interplay between psychological factors and dysfunction in the immune, neurological, and endocrine systems. A 2016 review suggested that although the peripheral nervous system is responsible for starting the condition, the central nervous system (CNS) is responsible for continuing the<unk>  even without continuing input from the peripheral nerves. Theories behind the disease include stress-driven hypothalamic-pituitary-adrenal axis dysfunction and adrenocortical hormone (endocrine) abnormalities, and neurogenic inflammation. Bacterial infection The bacterial infection theory was shown to be unimportant in a 2003 study which found that people with and without the condition had equal counts of similar bacteria colonizing their prostates. Overlap with IC/PBS In 2007 the NIDDK began to group IC/PBS (Interstitial Cystitis &<unk> ful Bladder<unk> and<unk>  under the umbrella term Urologic<unk><unk> <unk><unk> s (UCPPS). Therapies shown to be effective in treating IC/PBS, such as quercetin, have also shown some efficacy in<unk> . Recent research has focused on genomic and proteomic aspects of the related conditions. People may experience<unk>  with bladder filling, which is also a typical sign of IC. The Multidisciplinary Approach to the Study of<unk><unk> <unk>  (MAPP) Research Network has found that CPPS and bladder<unk><unk> /interstitial cystitis (BPS/IC) are related conditions.
Chronic prostatitis/chronic pelvic pain syndrome
Benign prostatic hyperplasia
symptom of Benign prostatic hyperplasia
Cancer
symptom of Urethral cancer
Prostatitis
symptoms of Bladder cancer
Overactive bladder