In<unk>  the<unk> -8 virus infects B cells and plasmablasts in lymph nodes and causes infected cells to release proinflammatory cytokines, signaling molecules that increase the activity of immune cells. In particular,<unk> -8 infection of immune cells leads to increased levels of Interleukin-6 (IL-6), a cytokine known to play a role in other forms of Castleman disease. The<unk> -8 virus contains a gene coding for a viral variant of the IL-6 molecule. Cells infected by<unk> -8 produce the viral variant of IL-6 and normal human IL-6, both of which contribute to the increased B cell proliferation and clinical findings seen in<unk> .
HHV-8-associated MCD
Cytomegalic inclusion body disease
Epstein–Barr virus–associated lymphoproliferative diseases
AIDS-related lymphoma
Fibrin-associated diffuse large B-cell lymphoma
Tuberculosis in relation to HIV
Hepatitis C and HIV coinfection
Epstein–Barr virus infection