Allergic ACS is a syndrome involving two components. One component is immune mediated resulting in hypersensitivity, allergy, and an anaphylactic or anaphylactoid reaction. The second component involves cardiac signs and symptoms seen with acute coronary syndrome (ACS). Cardiac symptoms vary depending on the type of variant the patient presents with. Acute coronary syndrome is usually associated with a constrictive pain in the chest, characteristically with radiation to the neck or the left arm and often associated with pallor, sweatiness, nausea and breathlessness. Cardiac signs on exam also include cold extremities, bradycardia, tachycardia, hypotension, possible cardiorespiratory arrest, or sudden death. Just as in an allergic reaction can vary from a mild and localized reaction to something that is widespread and life threatening, the allergic component of allergic ACS presents the same way. In allergic ACS there may also be specific symptoms relating to the underlying allergic reaction, such as swelling of the face and tongue, wheeze, hives and potentially very low blood pressure (anaphylactic shock). Additional findings can include stridor, drowsiness, syncope, abdominal pain, diarrhea, vomiting, and acute pulmonary edema if severe. Myocardial infarction, acute cardiac failure, and sudden cardiac death may also be seen. As high as 13% of adult onset sudden cardiac deaths are coupled with mast cell degranulation concluding that<unk>  can involve a silent allergic reaction.
Kounis syndrome
Kufor–Rakeb syndrome
Zunich–Kaye syndrome
STAR syndrome
Simpson–Golabi–Behmel syndrome
RAPADILINO syndrome
Qazi–Markouizos syndrome
Malouf syndrome