Loss of appetite and weight loss can occur. Additional signs are weakness, sore tongue, headaches, heart palpitations, irritability, and behavioral disorders. In adults, anemia (macrocytic, megaloblastic anemia) can be a sign of advanced<unk> . Women with<unk>  who become pregnant are more likely to give birth to low birth weight premature infants, and infants with neural tube defects and even spina bifida. In infants and children,<unk>  can lead to failure to thrive or slow growth rate, diarrhea, oral ulcers, megaloblastic anemia, neurological deterioration. An abnormally small head, irritability, developmental delay, seizures, blindness and cerebellar ataxia can also be observed.
Folate deficiency
Vitamin E deficiency
Properdin deficiency
Zinc deficiency
Hereditary folate malabsorption
Iron deficiency
Familial isolated vitamin E deficiency
Cerebral folate deficiency