<unk>  (also known as<unk> /acetaminophen) is the combination of the pain medications<unk>  and paracetamol (acetaminophen). It is used to treat moderate to severe pain. It is taken orally. Recreational use is common in the United States. Common side effects include dizziness, sleepiness, constipation, and vomiting. Serious side effects include addiction, decreased rate of breathing, low blood pressure, serotonin syndrome, severe allergic reactions, and liver failure. Use during pregnancy may harm the baby. Use with alcohol is not recommended.<unk>  works by binding to the mu-opioid receptor. How paracetamol works is unclear but may involve blocking the creation of prostaglandins.<unk>  was approved for medical use in the United States in 1982. In the United States, it is a schedule II controlled substance. In 2019, it was the fifteenth most commonly prescribed medication in the United States, with more than 30 million prescriptions. It is not available in the United Kingdom, though the combination codeine/paracetamol is. It is sold under the brand names Vicodin and Norco among others.
Hydrocodone/paracetamol
Oxycodone/ibuprofen
Hydrocodone/ibuprofen
Ibuprofen/paracetamol
Butalbital/acetaminophen
Celecoxib/tramadol
Naproxen/diphenhydramine
Phenylephrine/ketorolac