HCA2 is a high-affinity Gi/Go-coupled G protein-coupled receptor (GPCR) for nicotinic<unk>  (niacin), and is a member of the nicotinic<unk>  receptor family of GPCRs. HCA2 activation inhibits lipolytic and atherogenic activity (i.e., it inhibits the breakdown of fats and the development of atherosclerosis), induces vasodilation (i.e., the dilation of blood vessels), and is responsible for niacin-induced flushing. 5-oxo-ETE The mouse ortholog of HCA2, Niacr1, has been proposed to mediate the ability of 5-oxo-ETE, a member of the 5-HETE family of eicosanoids, to stimulate the production of steroidogenic acute regulatory protein mRNA, Steroidogenic acute regulatory protein, and thereby progesterone in mouse cultured MA-10 Leydig cells. Human tissues respond to 5-oxo-ETE and other 5-HETE family members though the OXER1 G protein-coupled receptor. The roles, if any, of Niacr1 in the response of leydig cells to other 5-HETE family members, of Niacr1 in the response of other mouse cells to 5-HETE family members, and the role of HCA2 in the response of human tissues to 5-HETE family members has not been determined.
Hydroxycarboxylic acid receptor 2
Growth hormone secretagogue receptor
Norepinephrine transporter
Prolactin-releasing peptide receptor
G protein-coupled receptor kinase 3
Thiamine transporter 1
Tropomyosin receptor kinase A
Prostaglandin-endoperoxide synthase 2