Surgery remains the front-line therapy for<unk> . Patients with Lynch syndrome who develop<unk><unk>  may be treated with either a partial colectomy or total colectomy with ileorectal anastomosis. Due to increased risk of<unk><unk>  following partial colectomy and similar quality of life after both surgeries, a total colectomy may be a preferred treatment for<unk> , especially in younger patients. There is an ongoing controversy over the benefit of 5-fluorouracil-based adjuvant therapies for<unk> -related<unk>  tumours, particularly those in stages I and II. * Anti-PD-1 antibody therapy can be effective. Checkpoint blockade with anti-PD-1 therapy is now preferred first line therapy for advanced Microsatellite-Instability–High<unk><unk> .
Hereditary nonpolyposis colorectal cancer
Familial adenomatous polyposis
MUTYH-associated polyposis
Serrated polyposis syndrome
Hereditary diffuse gastric cancer
Juvenile polyposis syndrome
Attenuated familial adenomatous polyposis
Peutz–Jeghers syndrome