<unk>  usually begins with arthritis at a young age, with the skin changes more prominent from the time of puberty. The arthritis is the predominant feature, noted by its juvenile onset and destructive course. Individuals often recall episodes of arthritis precipitated by a traumatic event. With repeated episodes the joints become damaged with multiple joint replacements required. Hopefully, with improved treatment options, the damage will be limited in new cases. Pyoderma gangrenosum is variably expressed, which means that it is not always present in all individuals with the disease. It presents as poorly healing ulcers with undermined edges. Pathergy is an important feature (this term refers to the tendency of ulcers to arise at points of injury). There are reports of lesions developing at the site of a joint replacement wound, central venous line and intravenous drip insertion. Acne affects most individuals with<unk>  but to a variable degree. It is usually of a severe nodulocystic type which if untreated results in scarring.
PAPA syndrome
PEHO syndrome
Saal Greenstein syndrome
Crandall syndrome
PHACE syndrome
Arts syndrome
Mietens syndrome
ANOTHER syndrome