An<unk>  is diagnosed if two or more of the following occur within 4 hours of cessation of transfusion: * Conjunctival edema * Edema of lips, tongue and uvula * Erythema and edema of the periorbital area * Generalized flushing * Hypotension * Localized angioedema * Maculopapular rash * Pruritus (itching) * Respiratory distress; bronchospasm * Urticaria (hives) A probable diagnosis results if any one of the following occurring within 4 hours of cessation of transfusion: * Conjunctival edema * Edema of lips, tongue and uvula * Erythema and edema of periorbital area * Localized angioedema * Maculopapular rash * Pruritus (itching) * Urticaria (hives) The UK hemovigilance reporting system (SHOT), has classified<unk>  reactions in to mild, moderate and severe. Reactions can occur that have features of both<unk>  and febrile reactions. Mild A rash, urticaria, or flushing Moderate Wheeze (bronchospasm) or angioedema but blood pressure normal and no respiratory compromise. There may or may not be an associated rash or urticaria. Severe This can be due to: * Severe breathing problems (Bronchospasm, stridor), angioedema, or circulatory problems (e.g. hypotension) which require immediate medical treatment OR admission to hospital OR lengthens the duration of hospital admission. * Anaphylaxis
Allergic transfusion reaction
Hypotensive transfusion reaction
Delayed hemolytic transfusion reaction
Transfusion associated circulatory overload
Acute hemolytic transfusion reaction
Transfusion transmitted infection
Activation syndrome
Transfusion-related immunomodulation