The<unk>  (FDP), proposed in 1992 by the British Toxicology Society, is a method to assess a substance's acute oral toxicity. In comparison to the older test developed in 1927, this<unk>  produces similar results while using fewer animals and causing less pain and suffering. As a result, in 1992 this test was proposed as an alternative to the LD50 test by the Organisation for Economic Co-operation and Development under OECD Test Guideline 420. However, the U.S. Food and Drug Administration has begun to approve non-animal alternatives in response to research cruelty concerns and the lack of validity/sensitivity of animal tests as they relate to humans.
Fixed-dose procedure
Remote dispensing
Reference dose
Contingency management
Active placebo
Outbreak response
Up-and-down procedure
Bedside manner