The<unk>  protein belongs to the beta chemokine receptors family of integral membrane proteins. It is a G protein–coupled receptor which functions as a chemokine receptor in the CC chemokine group.<unk> 's cognate ligands include CCL3, CCL4 (also known as MIP 1α and 1β, respectively), and CCL3L1.<unk>  furthermore interacts with CCL5 (a chemotactic cytokine protein also known as RANTES).<unk>  is predominantly expressed on T cells, macrophages, dendritic cells, eosinophils, microglia and a subpopulation of either breast or prostate cancer cells. The expression of<unk>  is selectively induced during the cancer transformation process and is not expressed in normal breast or prostate epithelial cells. Approximately 50% of human breast cancer expressed<unk> , primarily in triple negative breast cancer.<unk>  inhibitors blocked the migration and metastasis of breast and prostate cancer cells that expressed<unk> , suggesting that<unk>  may function as a new therapeutic target. Recent studies suggest that<unk>  is expressed in a subset of cancer cells with characteristics of cancer stem cells, which are known to drive therapy resistance, and that<unk>  inhibitors enhanced the number of cells killed by current chemotherapy. It is likely that<unk>  plays a role in inflammatory responses to infection, though its exact role in normal immune function is unclear. Regions of this protein are also crucial for chemokine ligand binding, the functional response of the receptor, and HIV co-receptor activity. Modulation of<unk>  activity contributes to a non-pathogenic course of infection with Simian immunodeficiency virus (SIV) in several African non-human primate species that are long-term natural hosts of SIV and avoid immunodeficiency upon the infection. These regulatory mechanisms include: genetic deletions that abrogate cell surface expression of<unk> , downregulation of<unk>  on the surface of CD4+ T cells, in particular on memory cells, and delayed onset of<unk>  expression on the CD4+ T cells during development. Primary Protein Sequence
CCR5
CCR2
CD137
LYRa11
CDV3 
LPAR6
FITkit
CD44