The gene for<unk> ,<unk> , spans 12 kb of DNA and contains 8 introns. It produces several mRNA that encode different<unk>  isoforms. Mutations in the<unk>  gene can be inherited, and are a cause of a rare inherited kidney disease, so far found to be present in only 2 families. This disease is autosomal dominant, meaning that it is characterized by a 50% chance of inheritance and is a slowly progressive chronic kidney disease that leads to the need for dialysis or kidney transplantation. Many—but not all—patients and families with this disease suffer from an elevation in serum potassium and unexplained anemia relatively early in life. Patients with a mutation in this gene can have a variable rate of loss of kidney function, with some individuals going on dialysis in their 40s while others may not go on dialysis until into their 70s. This is a rare inherited kidney disease that exists in less than 1% of people with kidney disease. Model organisms +<unk> 1 knockout mouse phenotype Characteristic Phenotype Homozygote viability Normal Fertility Normal Body weight Normal Anxiety Normal Neurological assessment Normal Grip strength Normal Hot plate Normal Dysmorphology Normal Non-Invasive Blood Pressure Abnormal Indirect calorimetry Normal Glucose tolerance test Normal Auditory brainstem response Normal DEXA Normal Radiography Normal Body temperature Normal Eye morphology Normal Clinical chemistry Normal Haematology Normal Micronucleus test Normal Heart weight Normal Skin Histopathology Normal Brain histopathology Normal Salmonella infection Normal Citrobacter infection Abnormal All tests and analysis from Model organisms have been used in the study of<unk>  function. A knockout mouse line, called<unk> 1Ren-1c Enhancer KO was generated. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on mutant mice and two significant abnormalities were observed. Homozygous mutant animals had a decreased heart rate and an increased susceptibility to bacterial infection. A more detailed analysis of this line indicated plasma creatinine was also increased and males had lower mean arterial pressure than controls.
Renin
Prorenin
Adrenalone
Thyroglobulin
Prolene
Modulin
Orexin
Vasopressin