Outcomes in lung cancer according to clinical stage Clinical stage Five-year survival (%) Non-small-cell lung carcinoma Small-cell lung carcinoma IA 50 38 IB 47 21 IIA 36 38 IIB 26 18 IIIA 19 13 IIIB 7 9 IV 2 1 Of all people with lung cancer in the US, around 17% to 20% survive for at least five years after diagnosis. In England and Wales, between 2013 and 2017, overall five-year survival for lung cancer was estimated at 13.8%. Outcomes are generally worse in the developing world. Due to late detection, the stage of lung cancer is often advanced at the time of diagnosis. At presentation, about one-third of cases of NSCLC have metastatic disease, and 60–70% of SCLC have extensive-stage disease. Survival for lung cancer falls as the stage at diagnosis becomes more advanced; the English data suggest that around 70% of patients survive at least a year when diagnosed at the earliest stage, but this falls to just 14% for those diagnosed with the most advanced disease (stage IV). Prognostic factors in NSCLC include presence of pulmonary symptoms, large tumor size (>3 cm), nonsquamous cell type (histology), degree of spread (stage) and metastases to multiple lymph nodes, and vascular invasion. For people with inoperable disease, outcomes are worse in those with poor performance status and weight loss of more than 10%. Prognostic factors in small cell lung cancer include performance status, biological sex, stage of disease, and involvement of the central nervous system or liver at the time of diagnosis. Overall survival in NSCLC patients treated with protocols incorporating immunotherapy in the first line for advanced or metastatic disease. Nasser NJ, Gorenberg M, Agbarya A. Pharmaceuticals 2020, 13(11), 373; For NSCLC, the best prognosis is achieved with complete surgical resection of stage-IA disease, with up to 70% five-year survival. People with extensive-stage SCLC have an average five-year survival rate less than 1%. The average survival time for limited-stage disease is 20 months, with a five-year survival rate of 20%. The prognosis of patients with NSCLC improved significantly in the last years with the introduction of immunotherapy. Patients with tumor PDL-1 expressed over half or more of the tumor cells achieved a median overall survival of 30 months with pembrolizumab. Multiple phase 3 trials providing immunotherapy in the first line for patients with non-small cell lung cancer have been published. According to data provided by the National Cancer Institute, the median age at diagnosis of lung cancer in the US is 70 years, and the median age at death is 72 years. In the US, people with medical insurance are more likely to have a better outcome.
medical cause of Hemoptysis
symptom of Lung cancer
types of Lung cancer
medical cause of Hemothorax
medical cause of Bronchiectasis
medical cause of Chylothorax
medical cause of Bronchiolitis
symptom of Bronchiectasis