<unk> , sold under the brand name Motilium among others, is a dopamine antagonist medication which is used to treat nausea and vomiting, certain gastrointestinal problems like gastroparesis (delayed gastric emptying), and to induce and promote breast milk production. It may be taken by mouth or rectally. Side effects of<unk>  include headache, dry mouth, abdominal cramps, diarrhea, and elevated prolactin levels. Secondary to increased prolactin levels, breast changes, milk outflow, menstrual irregularities, and hypogonadism can occur.<unk>  may also cause QT prolongation and has rarely been associated with serious cardiac complications such as sudden cardiac death. However, the risks are small and occur more with high doses.<unk>  acts as a peripherally selective antagonist of the dopamine D2 and D3 receptors. Due to its low entry into the brain, the side effects of<unk>  are different from those of other dopamine receptor antagonists like metoclopramide and it produces little in the way of central nervous system adverse effects.<unk>  was discovered in 1974 and was introduced for medical use in 1979. It was developed by Janssen Pharmaceutica.<unk>  is available over-the-counter in many countries, for instance in Europe and elsewhere throughout the world. It is not approved for use in the United States. A derivative of<unk>  called deudomperidone is currently under development for potential use in the United States and other countries.
Domperidone
Primidone
Chlortalidone
Thioridazine
Cinolazepam
Fluparoxan
Mepiprazole
Ziprasidone