In hemophilia it may occur spontaneously, and recurrent<unk>  are a major cause of disability in that patient group due to hemophilic arthropathy, requiring synovectomy, joint replacement and increased medical therapy to prevent further bleeding episodes. Reducing<unk>  events using intravenous administration of blood clotting factor concentrate on a regular basis starting in early childhood, reduces joint deterioration and increases the person's quality of life compared to "on demand" treatment (treating after a bleed). The minimal effective dose and best dosage frequency have not been established. It is not clear, due to lack of sufficient data, if preventative therapy with clotting factor concentrate is also effective at reducing joint deterioration if treatment is started after joint damage has occurred.
Hemarthrosis
Thrombophlebitis
Varicose veins
Phlebitis
Hemoperitoneum
Pulmonary hematoma
Retroperitoneal bleeding
Orthostatic purpura