<unk>  are a heterogeneous<unk>  of unconventional T<unk>  defined by their ability to recognize antigens bound on<unk> <unk> <unk>  molecules <unk> a,<unk> b and<unk> c) with their TCR. Natural killer T (NKT)<unk>  are a similar population with affinity to<unk> d (the only<unk>  2<unk>  molecule). Both<unk> s recognize lipid antigens in contrast to the conventional peptide antigens presented on MHC class<unk>  and 2 proteins. Most identified T-cells that bind<unk> <unk> <unk>  proteins are αβ T<unk>  and some are γδ T<unk> . Both foreign and endogenous lipid antigens activate these<unk> . The TCR usually recognizes the hydrophilic part of the antigen which protrudes outwards from the<unk>  protein after the lipid chains are bound in a groove. Small hydrophobic antigens lacking a polar part have also been shown to activate<unk> a-restricted T<unk> , indicating that in this case the TCR may bind<unk>  directly following displacement of nonimmunogenic ligands.
Group 1 CD1-restricted T cells
Persistent polyclonal B-cell lymphocytosis
Mutated citrullinated vimentin
Chimeric antigen receptor T cell
IgG4-related skin disease
Cross-reactive carbohydrate determinants
Deficiency of the interleukin-1–receptor antagonist
Antibodies from lymphocyte secretions