Medication and supplements Many oral treatments have been studied but results so far have been mixed. Some consider the use of nonsurgical approaches to be "controversial". Vitamin E supplementation has been studied for decades, and some success has been reported in older trials but those successes have not been reliably repeated in larger, newer studies. The use of Interferon-alpha-2b in the early stages of the disease has been studied but as of 2007 its efficacy was questionable. Collagenase clostridium histolyticum is reported to help by breaking down the excess collagen in the penis. It was approved for treatment of<unk>  by the FDA in 2013. Physical therapy and devices There is moderate evidence that penile traction therapy is a well-tolerated, minimally invasive treatment, but there is uncertainty about the optimal duration of stretching per day and per course of treatment, and the treatment course is difficult. Focused shockwave therapy Focused extracorporeal shockwave therapy is a non-invasive treatment option which involves passing acoustic pulses through the plaque, which can break it down over a series of six to twelve sessions. The treatment is most effective in men with mild to moderate<unk> 's. Surgery Surgery, such as the "Nesbit operation" (which is named after Reed M. Nesbit (1898–1979), an American urologist at University of Michigan), is considered a last resort and should only be performed by highly skilled urological surgeons knowledgeable in specialized corrective surgical techniques. A penile implant may be appropriate in advanced cases.
Peyronie's disease
Blount's disease
Minor's disease
Reis–Bucklers corneal dystrophy
Darier's disease
Sorsby's fundus dystrophy
Meesmann corneal dystrophy
Fundic gland polyposis