ISFL and ISMCL are generally asymptomatic disorders discovered in<unk>  tissues which were examined for other reasons. Typically, a follicle(s) in a superficial lymph node(s) is the site of these disorders. However, the follicles in deep lymph nodes the abdomen or of the tonsils, intestines, spleen, parotid gland, or thyroid may harbor the disorder in ISFL whereas a follicle(s) in the small intestine, appendix, ocular adnexa, nasopharynx, oropharynx, or spleen may harboring the disorder in ISMCL. The prevalence of these disorders in unselected lymph node specimens are reported to be ~2.8% and 0.35%, respectively. Multiple tissues can be involved in some cases. Both disorders occur predominantly in middle-aged and older individuals with ISFL being twice as common in males than females.
In situ lymphoid neoplasia
Benign lymphoepithelial lesion
Germ cell neoplasia in situ
Solitary lymphatic nodule
Intraepithelial neoplasia
Squamous intraepithelial lesion
Ductal carcinoma in situ
Epithelial dysplasia