+Receptor affinity profile Site Ki (nM) 2.5 1,427 5-HT2C 5,786 α1-adrenergic 1,288 σ1 36<unk>  is a potent selective serotonin reuptake inhibitor with around 100-fold affinity for the serotonin transporter over the norepinephrine transporter. It has negligible affinity for the dopamine transporter or any other site, with the sole exception of the σ1 receptor. It behaves as a potent agonist at this receptor and has the highest affinity (36 nM) of any SSRI for doing so. This may contribute to its antidepressant and anxiolytic effects and may also afford it some efficacy in treating the cognitive symptoms of depression. Unlike some other SSRI,<unk> 's metabolites are pharmacologically neutral.
Fluvoxamine
Medifoxamine
Phentermine
Gepirone
Pheniramine
Mephentermine
Doxepin
Sertindole