If<unk>  is administered concomitantly with other drugs, attention should be paid to the possible pharmacological interactions. Particular care should be taken with drugs that potentiate the effects of<unk> , such as barbiturates, phenothiazines, opioids, and antidepressants.<unk>  does not increase or decrease hepatic enzyme activity, and does not alter the metabolism of other compounds. No evidence would suggest<unk>  alters its own metabolism with chronic administration. Agents with an effect on hepatic cytochrome P450 pathways or conjugation can alter the rate of<unk>  metabolism. These interactions would be expected to be most significant with long-term<unk>  therapy, and their clinical significance is variable. *<unk>  increases the central depressive effects of alcohol, other hypnotics/sedatives (e.g., barbiturates), other muscle relaxants, certain antidepressants, sedative antihistamines, opioids, and antipsychotics, as well as anticonvulsants such as phenobarbital, phenytoin, and carbamazepine. The euphoriant effects of opioids may be increased, leading to increased risk of psychological dependence. * Cimetidine, omeprazole, oxcarbazepine, ticlopidine, topiramate, ketoconazole, itraconazole, disulfiram, fluvoxamine, isoniazid, erythromycin, probenecid, propranolol, imipramine, ciprofloxacin, fluoxetine, and valproic acid prolong the action of<unk>  by inhibiting its elimination. * Alcohol in combination with<unk>  may cause a synergistic enhancement of the hypotensive properties of benzodiazepines and alcohol. * Oral contraceptives significantly decrease the elimination of desmethyldiazepam, a major metabolite of<unk> . * Rifampin, phenytoin, carbamazepine, and phenobarbital increase the metabolism of<unk> , thus decreasing drug levels and effects. Dexamethasone and St John's wort also increase the metabolism of<unk> . *<unk>  increases the serum levels of phenobarbital. * Nefazodone can cause increased blood levels of benzodiazepines. * Cisapride may enhance the absorption, and therefore the sedative activity, of<unk> . * Small doses of theophylline may inhibit the action of<unk> . *<unk>  may block the action of levodopa (used in the treatment of Parkinson's disease). *<unk>  may alter digoxin serum concentrations. * Other drugs that may have interactions with<unk>  include antipsychotics (e.g. chlorpromazine), MAO inhibitors, and ranitidine. * Because it acts on the GABA receptor, the herb valerian may produce an adverse effect. * Foods that acidify the urine can lead to faster absorption and elimination of<unk> , reducing drug levels and activity. * Foods that alkalinize the urine can lead to slower absorption and elimination of<unk> , increasing drug levels and activity. * Reports conflict as to whether food in general has any effects on the absorption and activity of orally administered<unk> .
Diazepam
Adinazolam
Ketazolam
Halazepam
Midazolam
Triazolam
Thiazepine
Quazepam