<unk> , commonly referred to as the Blue Bible or<unk>  &<unk> , is a textbook of pharmacology originally authored by Louis S.<unk>  and Alfred<unk> . First published in 1941, the book is in its thirteenth edition (as of 2017), and has the reputation of being the "bible of pharmacology". The readership of this book include physicians of all<unk> and surgical specialties, clinical pharmacologists, clinical research professionals and pharmacists. While teaching jointly in the Yale School of Medicine's Department of Pharmacology,<unk>  and<unk>  began developing a course textbook that emphasized relationships between pharmacodynamics and pharmacotherapy, introduced recent<unk>  advances like sulfa drugs, and discussed the history of drug development. Yale physiologist John Farquhar Fulton encouraged them to publish the work for a broader audience and introduced them to a publisher at the Macmillan Publishing Company. Their new text was first published in 1941 under the title The<unk><unk>  of<unk> : A Textbook of Pharmacology, Toxicology and<unk>  for Physicians and Medical Student. Because the volume was twice as long as a typical textbook, Macmillan printed few copies, but demand for a readable, up-to-date<unk>  text proved high, and several printings followed. Although rapid<unk>  innovations were made in the years immediately following—including the introduction of chemotherapy, steroids, antibiotics, and antihistamines—a second edition could not be completed until 1955 because of the authors' service in World War II. Thereafter, the text was revised every five years in collaboration with a large number of specialist coauthors.<unk>  and<unk>  remained the book's lead editors for the first five editions;<unk>  remained an editor through the sixth edition, and<unk>  through the seventh, which was published shortly after<unk> 's death in 1984. Alfred<unk><unk> , the son of Alfred<unk>  and winner of the 1994 Nobel Prize in Medicine and Physiology, joined as senior editor for the book's sixth, seventh, and eighth editions, and a contributing editor to the ninth and tenth.<unk>  died in 2000, and<unk><unk>  in December 2015.
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