SPS is not caused by a single gene mutation. Several genetic abnormalities are associated with the condition, and a familial or inherited pattern may occur. Key genetic abnormalities include mutations in BRAF, abnormal CpG island methylator phenotype, and microsatellite instability. Additional implicated genes include: SMAD4, BMPR1A, PTEN, GREM1, and MUTYH. The only validated genetic cause of SPS is RNF43. However, most individuals with SPS do not have a germline mutation in any of the associated genes, including RNF43. As the underlying genetic risks for SPS are not fully understood, genetic testing is not recommended. Both autosomal dominant and autosomal recessive patterns of inheritance have been reported, as well as sporadic. Individuals with SPS have<unk>  polyps, which include hyperplastic polyps, traditional<unk>  adenomas, and sessile<unk>  polyps. In addition to<unk>  polyps, adenomas are often identified.
Serrated polyposis syndrome
Familial adenomatous polyposis
Juvenile polyposis syndrome
MUTYH-associated polyposis
Hereditary nonpolyposis colorectal cancer
Attenuated familial adenomatous polyposis
Peutz–Jeghers syndrome
Ogden syndrome