A higher number of cardiovascular events has been observed in people taking<unk>  versus control (11.4% vs. 10.0%). In 2010 the FDA noted the concerns that<unk>  increases the risk of heart attacks and strokes in patients with a history of cardiovascular disease. Frequently encountered side effects are: dry mouth, paradoxically increased appetite, nausea, strange taste in the mouth, upset stomach, constipation, trouble sleeping, dizziness, drowsiness, menstrual cramps/pain, headache, flushing, or joint/muscle pain. In a 2016 Cochrane review<unk>  was found to substantially increase blood pressure and heart rate in some patients, in the updated review in 2021<unk>  was not included since the drug had been withdrawn from the market. When used, regular blood pressure monitoring needed to be performed. The following side effects are infrequent but serious and require immediate medical attention: cardiac arrhythmias, paresthesia, mental/mood changes (e.g., excitement, restlessness, confusion, depression, rare thoughts of suicide). Symptoms that require urgent medical attention are seizures, problems urinating, abnormal bruising or bleeding, melena, hematemesis, jaundice, fever and rigors, chest pain, hemiplegia, abnormal vision, dyspnea and edema. Currently, no case of pulmonary hypertension has been noted. (Fenfluramine, of the 1990s "Fen-Phen" combo, forced excess release of neurotransmitters—a different action. Phentermine was uninvolved in the rare—but clinically significant—heart issues of fenfluramine.)
Sibutramine
Lofepramine
Quinupramine
Mitapivat
Metapramine
Nyasol
Tasimelteon
Pipotiazine