<unk>  is a genetically heterogeneous autosomal dominant trait, which can be passed down from one parent to child, who will have a 50% chance to inherit the mutated gene. An association with primary cilia defects has been reported. The mutations were found in the Zinc finger protein DZIP1 gene which regulates ciliogenesis; the same problem was found in mice who also developed<unk>  with this gene. It was found that primary cilia loss during development results in progressive myxomatous degeneration and profound mitral valve pathology. Myxomatous degeneration of mitral valve is a genetic abnormality mapped to gene Xq28. Other genes associated with<unk>  are: * 13.q31.3-q32.1 * 16p12.1-p11.2 * Ch16p11.2-p12.1 * 11p15.4 * DCHS1
Mitral valve prolapse
Da Costa's syndrome  Da Costa's syndrome  1
Mitral regurgitation
Aortic regurgitation
Mitral stenosis
Tricuspid regurgitation
Tricuspid valve stenosis
Pulmonary valve stenosis