The direct pathophysiology behind<unk>  is still unknown, but there are many postulated causes. Estrogen<unk>  is linked to increased sensitivity of the breast tissue to estradiol, an estrogen derivative, in certain prepubertal individuals. Sporadic estrogen or estradiol production in the adrenal glands, follicles or ovarian cysts is also linked to the condition. Follicle stimulating hormone Follicle Stimulating Hormone (FSH) is secreted from the anterior pituitary. FSH plays a key role in development, growth and puberty, thus it is suspected to play a role in<unk> . Gondotropin-releasing hormone (GnRH) stimulation testing in some patients with<unk>  has shown a dominant response from FSH. This response is linked to active mutations in the FSH receptor and Gs-a subunit in<unk> . Genetic investigation indicated these mutations only account for few cases of<unk> <unk> .<unk>  may also be caused by transient partial activation of the HPG axis. Partial activation would release a surplus of FSH from the anterior pituitary without further disruption of the HPG axis. Other causes The consumption or exposure to certain endocrine disrupters have also been linked to<unk> .
Premature thelarche
Panner disease
Prepubertal hypertrichosis
Microorchidism
Uncombable hair syndrome
Tricho–dento–osseous syndrome
Sexual maturation disorder
Adiposogenital dystrophy