As part of the renin–angiotensin–aldosterone system (RAAS) protective phase, soluble<unk> 's (sACE2) important function is to act as a counterbalance to the<unk> ACE). ACE cleaves<unk>  I hormone into the vasoconstricting<unk>  II which causes a cascade of hormonal reactions which is part of the body's harmful phase of RAAS, which ultimately leads to an increase in the body's blood pressure.<unk>  has an opposing effect to ACE, degrading<unk>  II into<unk>  (1-7), thereby lowering blood pressure. sACE2, as part of RAAS's protective phase, cleaves the carboxyl-terminal amino acid phenylalanine from<unk>  II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) and hydrolyses it into the vasodilator<unk>  (1-7) (H-Asp-Arg-Val-Tyr-Ile-His-Pro-OH), which binds to Mas Receptors and ultimately leads to a decrease in blood pressure. sACE2 can also cleave numerous peptides, including , apelin, neurotensin, dynorphin A, and ghrelin. mACE2 also regulates the membrane trafficking of the neutral amino acid transporter SLC6A19 and has been implicated in Hartnup's disease. Research in mice has shown that<unk>  (whether it is the membrane bound version or soluble is inconclusive) is involved in regulation of the blood glucose level but its mechanism is yet to be confirmed.
Angiotensin-converting enzyme 2
Prostaglandin-endoperoxide synthase 2
Haptocorrin
Calcitonin gene-related peptide
Indoleamine 2,3-dioxygenase
Immunoevasin
Tetanospasmin
Beta-secretase 1