<unk> , sold under the brand name Tofranil, among others, is a tricyclic antidepressant (TCA) mainly used in the treatment of depression. It is also effective in treating anxiety and panic disorder. The drug is also used to treat bedwetting.<unk>  is taken by mouth. Common side effects of<unk>  include dry mouth, drowsiness, dizziness, low blood pressure, rapid heart rate, urinary retention, and electrocardiogram changes. Overdose of the medication can result in death.<unk>  appears to work by increasing levels of serotonin and norepinephrine and by blocking certain serotonin, adrenergic, histamine, and cholinergic receptors.<unk>  was discovered in 1951 and was introduced for medical use in 1957. It was the first TCA to be marketed.<unk>  and the other TCAs have decreased in use in recent decades, due to the introduction of the selective serotonin reuptake inhibitors (SSRIs), which have fewer side effects and are safer in overdose.
Imipramine
Desipramine
Clomipramine
Trimipramine
Sertraline
Citalopram
Carpipramine
Methylphenidate