As an emotional and behavioral symptom in humans, someone is considered to be irritable when they have a short temper, become easily frustrated, or feel grouchy or grumpy. Caregivers may report tension in the household or fatigue. They may make accommodations to avoid provoking their dependents.<unk>  is associated with a number of mental health conditions. It is a defining characteristic of any mood disorder, such as bipolar, depressive, and disruptive mood dysregulation disorders. It is also a major feature of a number of other disorders, including autism spectrum disorders, traumatic stress disorders, generalized anxiety disorder, etc. Finally, it is a notable characteristic of delirium, dementia, hormonal change, metabolic disturbance, chronic stress, pain, and substance/medication withdrawal. Of course, given that<unk>  is not specific to any one condition, clinicians consider biological, social, psychological, and familial factors.<unk>  may be an indicator of diagnosis, course of illness, or prognosis. For example, a major concern for clinicians is the time course of<unk> . If a person presents as uncharacteristically irritable, then a clinician may become concerned a change or episodic illness, such as a neurologic insult or mood disorder. Understanding the time course of<unk>  is critical for establishing the diagnosis of pediatric bipolar disorder from disruptive mood dysregulation disorder. In another example, chronic, severe<unk>  in older children (not including young children, e.g. preschool age, where normative<unk>  may be severe) may predict later depression and anxiety and suicidality.
Irritability
Personality changes
Food craving
Irritation
Dryness 
Neurosis
Heat intolerance
Fatigue