It is suggested that, once diagnosed, individuals be routinely followed by a cardiologist, endocrinologist, dermatologist, and other appropriate specialties as symptoms present. It is recommended that those with the syndrome who are capable of having children seek genetic counseling before deciding to have children. As the syndrome presents frequently as a forme fruste (incomplete, or unusual form) variant, an examination of all family members must be undertaken. As an autosomal dominant trait there is a fifty percent chance with each child that they will also be born with the syndrome. Although fully penetrant, since the syndrome has variable expressivity, one generation may have a mild expression of the syndrome, while the next may be profoundly affected. Once a decision to have children is made, and the couple conceives, the fetus is monitored during the pregnancy for cardiac evaluation. If a gross cardiac malformation is found, parents receive counseling on continuing with the pregnancy. Other management is routine care as symptoms present: # For those with endocrine issues (low levels of thyrotopin a pituitary hormone responsible for regulating thyroid hormones, follicle stimulating hormone) drug therapy is recommended. # For those who are disturbed by the appearance of<unk> , cryosurgery may be beneficial. Due to the large number of<unk>  this may prove time-consuming. An alternative treatment with tretinoin or hydroquinone creams may help. # Drug therapies for those with cardiac abnormalities, as those abnormalities become severe enough to warrant the use of these therapies. ECG's are mandatory prior to any surgical interventions, due to possible arrythmia.
Noonan syndrome with multiple lentigines
Multiple hamartoma syndrome
Hemihyperplasia–multiple lipomatosis syndrome
Sabinas brittle hair syndrome
Tuber cinereum hamartoma
Acorea, microphthalmia and cataract syndrome
Pure hair-nail type ectodermal dysplasia
Lenz microphthalmia syndrome