In a process known as downregulation, daily stimulation of pituitary gonadotropes causes them to become desensitized to the effects of<unk> . As a consequence, levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) fall after a short period of time. From that point forward, as long as<unk>  is administered, the levels of LH and FSH in the blood remain low. This prolonged lowering of LH and FSH levels is the rationale for therapy using GnRH agonists. Since LH and FSH stimulate the gonads to produce estrogens and androgens in females and males respectively,<unk>  can effectively be used to decrease the sex steroids in the blood of patients.
Histrelin
Ghrelin
Incretin
Somatostatin
Nesfatin-1
Agouti-related peptide
Beta-Endorphin
Prolactin-releasing peptide