<unk>  may affect the amount of fat absorbed, yet they do not block the absorption of a particular type of fat. Likewise,<unk>  are not absorbed into the bloodstream.<unk>  bind to<unk>  enzymes in the intestine, thus preventing the hydrolysis of dietary triglycerides into monoglycerides and fatty acids. This then reduces the absorption of dietary fat.<unk>  covalently bond to the active serine site on<unk> s. This covalent bond is strong, meaning the<unk> tends to remain attached to the<unk> . Studies have shown that<unk>  work optimally when 40% of an individual's daily caloric intake is obtained from fat. Orlistat tends to block absorption of 30% of total fat intake from a meal, as orlistat passes out of the digestive tract more rapidly than fat does.
Lipase inhibitors
COX-2 inhibitor
Steroid ester
Bile acid sequestrant
Quinolone antibiotic
Protease inhibitor 
Antiplatelet drug
Prostaglandin inhibitors