<unk>  (also known as tramiprosate (INN), 3-amino-1-propanesulfonic acid, or 3-APS) is a natural amino acid found in seaweed. It is analogous to taurine, but with an extra carbon in its chain. It has GABAergic activity, apparently by mimicking GABA, which it resembles.<unk>  was investigated in a Phase III clinical trial as a potential treatment for Alzheimer's disease (AD) that did not show efficacy. However, post-hoc analyses have shown positive and significant effects of<unk>  on secondary endpoints and subgroups of patients, including a reduction in hippocampal volume loss and lower decline in memory function in the overall cohort, as well as a reduction in global cognitive decline in APOE4 allele carriers, suggesting a disease-modifying effects. A study in cognitive impairment done in 2018 did show positive benefits.<unk>  is currently in a phase 3 study with expected FDA approval as the first disease modifying drug for AD.
Homotaurine
Uridine triacetate
Indoxyl sulfate
Doisynolic acid
Cysteamine
3-Methylhistidine
Fructosamine
Choline