Common side effects are headache, nausea, vomiting, abdominal pain, diarrhea, fatigue, musculoskeletal pain (pain in the body affecting bones, muscles, ligaments, tendons and nerves), fever, dry skin, acneiform rash (acne) and other rashes, stomatitis (inflammation of the mouth and lips), paronychia (infection in the skin that surrounds a toenail or fingernail) and pruritus (itching).<unk>  can also cause serious side effects including heart failure (manifested as ejection fraction decrease, or when the muscle of the left ventricle of the heart is not pumping as well as normal) and eye toxicity (acute and chronic damage to the eye) including retinal vein occlusion, retinal pigment epithelial detachment and impaired vision.<unk>  can also cause increased creatinine phosphokinase (CPK). CPK is an enzyme found in the heart, brain and skeletal muscles. When muscle tissue is damaged, CPK leaks into a person's blood, which can be a sign of rhabdomyolysis (breakdown of skeletal muscle due to direct or indirect muscle injury). Further,<unk>  capsules contain vitamin E, and users are at an increased risk of bleeding if their daily intake of vitamin E exceeds the recommended or safe limits.
Selumetinib
Binimetinib
Cobimetinib
Pralsetinib
Lestaurtinib
Axitinib
Mobocertinib
Gefitinib