Hyperlipidemia As<unk>  acids are biosynthesized from cholesterol, disruption of<unk>  acid reabsorption will decrease cholesterol levels, in particular, low-density lipoprotein (commonly known as "bad cholesterol") in blood. Consequently, these drugs have been used for the treatment of hypercholesterolemia and dyslipidemia. Use of these agents as hypolipidemic agents has decreased markedly since the introduction of the statins, which are more efficacious than<unk> s at lowering LDL. They are occasionally used as an adjunct to the statins as an alternative to the fibrates (another major group of cholesterol-lowering drugs), which are thought to increase the risk of rhabdomyolysis when used with statins. The<unk> -acid-binding resins can raise triglycerides modestly (about 5%) and cannot be used if the triglycerides are elevated.<unk>  acid malabsorption Chronic diarrhea may be caused by excess<unk>  salts entering the colon rather than being absorbed at the end of the small intestine (the ileum). This condition of<unk>  acid malabsorption occurs after surgery to the ileum, in Crohn's disease, with a number of other gastrointestinal causes, or is commonly a primary, idiopathic condition. The SeHCAT test can be used for diagnosis.<unk>  salt diarrhea can also be a side-effect of gallbladder removal.<unk> s are the principal therapy for<unk>  acid-induced diarrhea. Cholestyramine, colestipol and colesevelam have all been used. Doses may not need to be as high as those previously used for hyperlipidemia. Many patients find them hard to tolerate, as although the diarrhea may improve, bloating and abdominal pain can worsen. Use in other conditions In chronic liver diseases such as cirrhosis,<unk>  acids may deposit in the skin, causing pruritus (itching). Hence,<unk> s may be used for the prevention of pruritus in patients with chronic liver disease.<unk> s may also be used to treat hyperthyroidism as an adjunct therapy. By inhibiting the enterohepatic circulation, more L-thyroxine will be lost through defecation, thus lowering body thyroxine levels. Cholestyramine has been used in the treatment of Clostridioides difficile infections, in order to absorb toxins A and B.
Bile acid sequestrant
Lipase inhibitors
Proton-pump inhibitor
Omega-3 carboxylic acids
Caloric restriction mimetic
Steroid ester
Chenodeoxycholic acid
Phosphate binder