Mechanism of action<unk>  is a nonapeptide, desamino-oxytocin analogue, and a competitive vasopressin/oxytocin receptor antagonist (VOTra).<unk>  inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result, reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells and reduced influx of Ca2+ from the extracellular space through voltage-gated channels occur. In addition,<unk>  suppresses oxytocin-mediated release of PGE and PGF from the decidua. In human preterm labour,<unk> , at the recommended dosage, antagonises uterine contractions and induces uterine quiescence. The onset of uterus relaxation following<unk>  is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence.
Atosiban
Tolevamer
Vosoritide
Trilostane
Oprelvekin
Progabide
Danaparoid
Bulevirtide