<unk>  has been proposed to have a unique dual mechanism of action as a positive modulator of GABAA receptors and as a blocker of NMDA receptors, particularly isoforms containing the NR2B subunit. Although it is clear that<unk>  does cause pharmacological inhibition of NMDA receptors, the relevance of NMDA receptor blockade as a strategy for the treatment of human epilepsy has been questioned. Therefore, the importance of the effects of<unk>  on NMDA receptors to its therapeutic action in epilepsy is uncertain.
Felbamate
Topiramate
Cenobamate
Tetrabamate
Lamotrigine
Phenylpiracetam
Tiagabine
Levetiracetam