<unk>  <unk> , also termed inclusion body fibromatosis, Reye tumor, or Reye's tumor, usually occurs as a single, small, asymptomatic, nodule in the dermis on a finger or toe of infants and young children. IMF is a rare disorder with approximately 200 cases reported in the medical literature as of 2021. The World Health Organization, 2020, classified these nodules as a specific benign tumor type in the category of fibroblastic and myofibroblastic tumors.<unk>  was first described by the Australian pathologist, Douglas Reye, in 1965.<unk>  consists of an overgrowth of spindle-shaped cells in a collagen fiber-rich background located in the dermis (i.e. the layer of skin between the epidermis and subcutaneous tissue) but may extend into the subcutaneous tissue. These spindle-shaped cells contain distinctive inclusion bodies within their cytoplasm that greatly help in distinguishing<unk>  from other fibrous skin diseases. These inclusions are composed of densely packed vimentin and actin filaments<unk>  lesions are usually painless and have a tendency to regress spontaneously. Consequently, the current recommended treatment for<unk>  nodules is conservative observation. If the lesions cause local deformities and/or functional impairments or continue to increase in size over long observation periods, surgical removal is recommended. However, surgically removed<unk>  lesions have had high rates of recurrence and this surgery may cause post-operative<unk>  deformities.
Infantile digital fibromatosis
Plantar fibromatosis
Juvenile plantar dermatosis
Superficial acral fibromyxoma
Aggressive infantile fibromatosis
Juvenile hyaline fibromatosis
Subungual exostosis
Diffuse infantile fibromatosis