<unk>  (B-cell lymphoma 2), encoded in humans by the<unk>  gene, is the founding member of the<unk>  family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis. It was the first apoptosis regulator identified in any organism.<unk>  derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular lymphomas. Orthologs (such as<unk>  in mice) have been identified in numerous mammals for which complete genome data are available. Like BCL3, BCL5, BCL6, BCL7A, BCL9, and BCL10, it has clinical significance in lymphoma.
Bcl-2
Bcl-xL
P73
Mad2
FOXC2
FOXP3
C-Fos
IKK2