Diagnosis of the medical condition is based on a combination of clinical presentation, physical exam, and laboratory studies. When this characteristic rash is found in a neonate, laboratory workup is prompted. Initial workup usually includes a complete blood count (CBC) with differential to evaluate for underlying blood disorders. Laboratory confirmation of the cause of the<unk><unk>  rash depends on the underlying illness. For example, serology positive for rubella specific antibodies, viral culture with isolated rubella, or isolation of rubella virus RNA through polymerase chain reaction can all confirm that congenital rubella infection is the underlying cause of the<unk><unk>  rash. Other manifestations of congenital rubella disease can also appear in conjunction with the characteristic rash. These include congenital glaucoma, jaundice, hepatosplenomegaly, microcephaly, cataracts, or sensorineural hearing loss. The presence of these features can further bolster the diagnosis of congenital rubella as the cause of the<unk> . Laboratory studies for congential rubella infection should be done prior to 1 year of age as diagnosis becomes more challenging afterwards. In the case of infection with cytomegalovirus (CMV), patients can present with associated symptoms such as deafness and chorioretinitis. On lab studies, there may be a high anti-cytomegalovirus antibody titer, positive CMV urine culture, and thrombocytopenia. If the cause is due to hemolytic disease of the newborn or hereditary spherocytosis, the neonate will have a positive Coomb's test and unconjugated hyperbilirubinemia. Malignancies such as neuroblastoma and acute myeloid leukemia are all rare but possible causes of a<unk> . Most of the time, these conditions are diagnosed using immunohistochemistry and biopsy.
Blueberry muffin baby
Lotus birth
Vanishing twin
Subcutaneous fat necrosis of the newborn
Tetter
Blue baby syndrome
Chordee
Charley horse