Signs of<unk>  include a positive direct Coombs test (also called direct agglutination test), elevated cord bilirubin levels, and<unk>  anemia. It is possible for a<unk>  with this<unk>  to have neutropenia and neonatal alloimmune thrombocytopenia as well. Hemolysis leads to elevated bilirubin levels. After delivery, bilirubin is no longer cleared (via the placenta) from the neonate's blood and the symptoms of jaundice (yellowish skin and yellow discoloration of the whites of the eyes, or icterus) increase within 24 hours after birth. Like other forms of severe neonatal jaundice, there is the possibility of the neonate developing acute or chronic kernicterus, however the risk of kernicterus in<unk>  is higher because of the rapid and massive destruction of blood cells. It is important to note that isoimmunization is a risk factor for neurotoxicity and lowers the level at which kernicterus can occur. Untreated profound anemia can cause high-output heart failure, with pallor, enlarged liver and/or spleen, generalized swelling, and respiratory distress.<unk>  can be the cause of hydrops fetalis, an often-severe form of prenatal heart failure that causes fetal edema. Complications Complications of<unk>  could include kernicterus, hepatosplenomegaly, inspissated (thickened or dried) bile syndrome and/or greenish staining of the teeth,<unk>  anemia and damage to the liver due to excess bilirubin. Conditions that may cause similar symptoms in the<unk>  period include: acquired<unk>  anemia, congenital toxoplasma, congenital syphilis infection, congenital obstruction of the bile duct, and cytomegalovirus (CMV) infection. * High at birth or rapidly rising bilirubin * Prolonged hyperbilirubinemia * Bilirubin Induced Neurological Dysfunction * Cerebral Palsy * Kernicterus * Neutropenia * Thrombocytopenia *<unk>  anemia – Must NOT be treated with iron * Late onset anemia – Must NOT be treated with iron. Can persist up to 12 weeks after birth.
Hemolytic disease of the newborn
Neonatal meningitis
Neonatal hepatitis
Michelin tire baby syndrome
Neonatal diabetes
Shaken baby syndrome
Twin-to-twin transfusion syndrome
Neonatal toxic shock-like exanthematous disease