A serious side-effect of<unk>  is<unk> -induced thrombocytopenia (HIT), caused by an immunological reaction that makes platelets a target of immunological response, resulting in the degradation of platelets, which causes thrombocytopenia. This condition is usually reversed on discontinuation, and in general can be avoided with the use of synthetic<unk> s. Also, a benign form of thrombocytopenia is associated with early<unk>  use, which resolves without stopping<unk> . Two non-hemorrhagic side-effects of<unk>  treatment are known. The first is elevation of serum aminotransferase levels, which has been reported in as many as 80% of patients receiving<unk> . This abnormality is not associated with liver dysfunction, and it disappears after the drug is discontinued. The other complication is hyperkalemia, which occurs in 5 to 10% of patients receiving<unk> , and is the result of<unk> -induced aldosterone suppression. The hyperkalemia can appear within a few days after the onset of<unk>  therapy. More rarely, the side-effects alopecia and osteoporosis can occur with chronic use. As with many drugs, overdoses of<unk>  can be fatal. In September 2006,<unk>  received worldwide publicity when three prematurely born infants died after they were mistakenly given overdoses of<unk>  at an Indianapolis hospital. Contraindications<unk>  is contraindicated in those with risk of bleeding (especially in people with uncontrolled blood pressure, liver disease, and stroke), severe liver disease, or severe hypertension. Antidote to<unk>  Protamine sulfate has been given to counteract the anticoagulant effect of<unk>  (1 mg per 100 units of<unk>  that had been given over the past 6 hours). It may be used in those who overdose on<unk>  or to reverse<unk> 's effect when it is no longer needed.
Heparin
Prokarin
Ticlopidine
Palladin
Argatroban
Lepirudin
Hirudin
Tissue plasminogen activator