Gout<unk>  is an alternative for those unable to tolerate NSAIDs when treating gout. Low doses appear to be well tolerated and may reduce gout symptoms and pain (1.2 mg in one hour, followed by 0.6 mg an hour later). This low dose may have a similar effectiveness to NSAIDS (low quality evidence). At high doses, side effects (primarily diarrhea, nausea, or vomiting) limit its use, however may be effective against pain. In addition, there is preliminary evidence that daily<unk>  (0.6 mg twice daily) may be effective as a long-term prophylaxis when used with allopurinol to reduce the risk of increased uric acid levels and acute gout flares, although adverse gastrointestinal effects may occur. For treating gout symptoms,<unk>  is used orally with or without food, as symptoms first appear. Subsequent doses may be needed if symptoms worsen. Other conditions<unk>  is also used as an anti-inflammatory agent for long-term treatment of Behçet's disease. It appears to have limited effect in relapsing polychondritis, as it may only be useful for the treatment of chondritis and mild skin symptoms. It is a component of therapy for several other conditions, including pericarditis, pulmonary fibrosis, biliary cirrhosis, various vasculitides, pseudogout, spondyloarthropathies, calcinosis, scleroderma, and amyloidosis. Research regarding the efficacy of<unk>  in many of these diseases has not been performed. It is also used in the treatment of familial Mediterranean fever, in which it reduces attacks and the long-term risk of amyloidosis.<unk>  is effective for prevention of atrial fibrillation after cardiac surgery. Potential applications for the anti-inflammatory effect of<unk>  have been studied with regard to atherosclerosis and chronic coronary disease (e.g., stable ischemic heart disease). In people with recent myocardial infarction (recent heart attack), it has been found to reduce risk of future cardiovascular events. Its clinical use may grow to include this indication.<unk>  is also being studied in clinical trials for possible effects on treating of COVID-19.
Colchicine
Diclofenac
Ketoprofen
Aceclofenac
Meclofenamic acid
Allopurinol
Diclofenamide
Indoprofen