<unk>  is a congenital syndrome characterized by<unk>  (swelling of tissue due to malformation or malfunction of lymphatics), the presence of telegiectasias (small dilated vessels near the surface of the skin), and<unk>  or alopecia (hair loss).<unk>  usually develops in the lower extremities during puberty. Hair is normal at birth, but usually lost during infancy.<unk> s may present on the palms and soles more commonly than on the scalp, legs, and genitalia. The syndrome has been reported in association with both autosomal dominant and autosomal recessive inheritance patterns. It is associated with a rare mutation of the transcription factor gene SOX18.
Hypotrichosis–lymphedema–telangiectasia syndrome
Pitt–Hopkins syndrome
Crome syndrome
Kasabach–Merritt syndrome
Swyer–James syndrome
Bowel-associated dermatosis–arthritis syndrome
SUNCT syndrome
Rapp–Hodgkin syndrome