<unk>  <unk>  is an AIS condition that results in the<unk>  inability of the cell to respond to androgens. As such, the<unk>  to androgens is only clinically significant when it occurs in individuals who are exposed to significant amounts of testosterone at some point in their lives. The unresponsiveness of the cell to the presence of androgenic hormones prevents the masculinization of male genitalia in the developing fetus, as well as the development of male secondary sexual characteristics at puberty, but does allow, without significant impairment, female genital and sexual development in those with the condition. All human fetuses begin fetal development looking similar, with both the Müllerian duct system (female) and the Wolffian duct system (male) developing. It is at the seventh week of gestation that the bodies of unaffected individuals with the XY karyotype begin their masculinization: i.e, the Wolffian duct system is promoted and the Müllerian duct system is suppressed (the reverse happens with typically developing females). This process is triggered by androgens produced by the gonads, which in individuals with the XX karyotype had earlier become ovaries, but in XY individuals typically had become testicles due to the presence of the Y Chromosome. The cells of unaffected XY individuals then masculinize by, among other things, enlarging the genital tubercle into a penis, which in females becomes the clitoris, while what in females becomes the labia fuses to become the scrotum of males (where the testicles will later descend). Individuals affected by<unk>  develop a normal external female habitus, despite the presence of a Y chromosome, but internally, they will lack a uterus, and the vaginal cavity will be shallow, while the gonads, having been turned into testicles rather than ovaries in the earlier separate process also triggered by their Y chromosome, will remain undescended in the place where the ovaries would have been. This results not only in infertility in individuals with<unk> , but also presents a risk of gonadal cancer later on in life.<unk>  is one of the three categories of androgen<unk>  syndrome (AIS) since AIS is differentiated according to the degree of genital masculinization:<unk>  <unk>  when the external genitalia is that of a typical female, mild androgen<unk>  syndrome (MAIS) when the external genitalia is that of a typical male, and partial androgen<unk>  syndrome (PAIS) when the external genitalia is partially, but not fully masculinized. Androgen<unk>  syndrome is the largest single entity that leads to 46, XY undermasculinization.
Complete androgen insensitivity syndrome
Mild androgen insensitivity syndrome
Partial androgen insensitivity syndrome
Androgen insensitivity syndrome
Estrogen insensitivity syndrome
Gonadotropin-releasing hormone insensitivity
Kallmann syndrome
Klinefelter syndrome