Pharmacodynamics +<unk>  Site Ki (nM) Species Ref ' ' ' >100,000 Rat 5-HT1A >10,000 Rat 5-HT2A ≥1,500 Rat 5-HT2C α1 >10,000 Rat α2 >10,000 Rat DA >10,000 Bovine H1 23 Human H2 1,950 Human H3 >100,000 Human H4 >100,000 Human 1,750 Rat Values are Ki (nM). The smaller the value, the more strongly the drug binds to the site.<unk>  acts as a selective norepinephrine reuptake inhibitor (NRI), with similar potency to that of imipramine. It is also a potent antihistamine. The drug has weak or negligible effects on serotonin and dopamine reuptake. Unlike many other TCAs,<unk>  has no antiadrenergic (α1, α2), antiserotonergic (5-HT1A, 5-HT2A), or antidopaminergic effects and has few or no anticholinergic () effects. Pharmacokinetics Therapeutic levels of<unk>  are approximately 85 to 850 nM. Its plasma protein binding is approximately 80%.
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Tripelennamine
Desomorphine
Atogepant
Bocasan
Cidoxepin
Apomorphine
Bolazine