In the United States, manufacturers of<unk> s are required to demonstrate safety of their products before approval is granted for commerce. Despite this caution, numerous adverse effects have been reported, including muscle cramps, hair loss, joint pain, liver disease, and allergic reactions, with 29% of the adverse effects resulting in hospitalization, and 20% in serious injuries or illnesses. The potential for adverse effects also occurs when individuals consume more than the necessary daily amount of vitamins or minerals that are needed to maintain normal body processes and functions. The incidence of adverse effects reported to the FDA were due to "combination products" that contain multiple ingredients, whereas<unk> s containing a single vitamin, mineral, lipid product, and herbal product were less likely to cause adverse effects related to excess<unk> ation. Among general reasons for the possible harmful effects of<unk> s are: a) absorption in a short time, b) manufacturing quality and contamination, and c) enhancing both positive and negative effects at the same time. The incidence of liver injury from herbal and<unk> s is about 16–20% of all<unk>  products causing injury, with the occurrence growing globally over the early 21st century. The most common liver injuries from weight loss and bodybuilding<unk> s involve hepatocellular damage with resulting jaundice, and the most common<unk>  ingredients attributed to these injuries are green tea catechins, anabolic steroids, and the herbal extract, aegeline. Weight loss<unk> s have also had adverse psychiatric effects. Some<unk> s may also have adverse interactions with prescription medications that may enhance side effects or decrease therapeutic effects of medications.
Dietary supplement
Diet 
Diabetes medication
Ultra-processed food
Concomitant drug
Vegetation 
Drug
Drug 