Produced mainly in the liver,<unk> sminogen is the inactive zymogen form of<unk> smin, and circulates in<unk> sma in a closed conformation that cannot be activated. Binding clots or cell surface causes its conformation to change, allowing it to be activated by<unk> s.<unk> s do so by cleaving the R561/V562 peptide bond, producing the active protein<unk> smin, which catalyzes the degradation of fibrin polymers that make up the structure of blood clots. 3-dimensional structure of tPA 3-dimensional structure of uPA
Plasminogen activator
Endopeptidase inhibitor
Tissue factor pathway inhibitor
Fibrinolysis
Thrombolysis
Exopeptidase inhibitor
Anticoagulant
Anistreplase