<unk> s, also known as<unk>  zone lymphomas <unk> s), are a heterogeneous group of lymphomas that derive from the malignant transformation of<unk>  zone B-cells.<unk>  zone B<unk> s are innate lymphoid<unk> s that normally function by rapidly mounting IgM antibody immune responses to antigens such as those presented by infectious agents and damaged tissues. They are lymphocytes of the B-cell line that originate and mature in secondary lymphoid follicles and then move to the<unk>  zones of mucosa-associated lymphoid tissue (i.e. MALT), the spleen, or lymph nodes. Mucosa-associated lymphoid tissue is a diffuse system of small concentrations of lymphoid tissue found in various submucosal membrane sites of the body such as the gastrointestinal tract, mouth, nasal cavity, pharynx, thyroid gland, breast, lung, salivary glands, eye, skin and the human spleen. In 2016, the World Health Organization classified<unk> s into three different types. Extranodal<unk>  zone lymphomas (EMZLs) are<unk> s that develop in extranodal tissues. Most EMZLs develop in MALT and are often termed extranodal<unk>  of mucosa-associated lymphoid tissue or, more simply, MALT lymphomas. Splenic<unk>  zone lymphomas (SMZLs) are<unk> s that initially are confined to the spleen, bone marrow, and blood. Nodal<unk>  zone lymphomas (NMZs) are<unk> s initially confined to lymph nodes, bone marrow, and blood. While all of these<unk>  involve malignant B-cells, they differ not only in the tissues they involve but also in their pathophysiology, clinical presentations, prognoses, and treatments.<unk> s represent 5-17% of all Non-Hodgkin lymphomas with the extranodal, splenic, and nodal forms accounting for 50-70%, ~20%, and ~10% of all<unk> s. The three<unk>  subtypes occur more often in older people (age 65–68 years) and are indolent diseases that may, in people without symptoms, be initially treated by a watchful waiting strategy. However, NMZL carries a somewhat worse long term outcome than the other subtypes and any of the<unk>  subtypes may progress in a low percentage of cases to a more aggressive lymphoma, particularly diffuse large B-cell lymphoma. One of the most distinctive feature of<unk>  is that many cases are associated with the persistent simulation of the immune system by the chronic inflammation that accompanies infections or autoimmune diseases.<unk>  cases associated with certain infectious pathogens can be cured by treatment directed at the pathogens causing or associated with these infections.
Marginal zone B-cell lymphoma
Nodal marginal zone B cell lymphoma
Fibrin-associated diffuse large B-cell lymphoma
Pediatric-type follicular lymphoma
Diffuse large B-cell lymphoma
Follicular lymphoma
Splenic marginal zone lymphoma
Mixed-cell lymphoma