<unk> s (5-ARIs), also known as dihydrotestosterone (DHT) blockers, are a class of medications with antiandrogenic effects which are used primarily in the treatment of enlarged prostate and scalp hair loss. They are also sometimes used to treat excess hair growth in women and as a component of hormone therapy for transgender women. These agents inhibit the enzyme<unk><unk> , which is involved in the metabolic transformations of a variety of endogenous steroids. 5-ARIs are most known for preventing conversion of testosterone, the major androgen sex hormone, to the more potent androgen dihydrotestosterone (DHT), in certain androgen-associated disorders.
5α-Reductase inhibitor
Aromatase inhibitor
Antiandrogen
Steroidogenesis inhibitor
N-Terminal domain antiandrogen
Reuptake inhibitor
COX-2 inhibitor
Selective androgen receptor modulator