Guanethidine, an<unk> .<unk> s are a class of drugs which inhibit the<unk>  of epinephrine (adrenaline) and/or norepinephrine (noradrenaline) from<unk>  nerve terminals and are used as antihypertensives. Examples of these agents include bethanidine, bretylium, debrisoquine, guanadrel, guanazodine, guancydine, guanethidine, guanoclor, and guanoxan. Most agents of this class are guanidinium compounds and have little capacity to cross the blood–brain barrier.
Adrenergic release inhibitor
Adrenergic blocking agent
Norepinephrine–dopamine releasing agent
Serotonin–dopamine releasing agent
Serotonin–norepinephrine–dopamine releasing agent
Norepinephrine–dopamine disinhibitor
Serotonin–norepinephrine releasing agent
Alpha-adrenergic agonist