A<unk>  is an environment in a secondary organ that can be conducive to the metastasis of a primary tumor. Such a<unk>  provides favorable conditions for growth, and eventual metastasis, in an otherwise foreign and hostile environment for the primary tumor cells. This concept demonstrated the fundamental role of the microenvironment in regulating tumor growth and metastasis. The discovery of the<unk>  has fostered new research regarding the potential treatment of metastases, including targeting myeloid derived suppressor cells, and stromal cell plasticity including fibroblasts and pericytes and perivascular smooth muscle cells and (attempts to stop the flow of vesicles from primary tumors to<unk> s in secondary organs and different combinations of microenvironment targeted therapies.
Pre-metastatic niche
Tumor budding
Granulation tissue
Micrometastasis
Angiosome
Lobulation
Craterization
Tissue expansion