<unk> , sold under the brand name Evista among others, is a medication used to prevent and treat osteoporosis in postmenopausal women and those on glucocorticoids. For osteoporosis it is less preferred than bisphosphonates. It is also used to reduce the risk of breast cancer in those at high risk. It is taken by mouth. Common side effects include hot flashes, leg cramps, swelling, and joint pain. Severe side effects may include blood clots and stroke. Use during pregnancy may harm the baby. The medication may worsen menstrual symptoms.<unk>  is a selective estrogen receptor modulator (SERM) and therefore a mixed agonist–antagonist of the estrogen receptor (ER). It has estrogenic effects in bone and antiestrogenic effects in the breasts and uterus.<unk>  was approved for medical use in the United States in 1997. It is available as a generic medication. In 2017, it was the 330th most commonly prescribed medication in the United States, with more than 900 thousand prescriptions.
Raloxifene
Bazedoxifene
Lasofoxifene
Ormeloxifene
Tamoxifen
Denosumab
Endoxifen
Teriparatide