Immunodysregulation polyendocrinopathy enteropathy X-linked (or<unk>  is a rare disease linked to the dysfunction of the gene encoding transcription factor forkhead box P3 (FOXP3), widely considered to be the master regulator of the regulatory T cell lineage. It leads to the dysfunction of CD4+ regulatory T-cells and the subsequent autoimmunity. The disorder is one of the autoimmune polyendocrine syndromes and manifests with autoimmune enteropathy, psoriasiform or eczematous dermatitis, nail dystrophy, autoimmune endocrinopathies, and autoimmune skin conditions such as alopecia universalis and bullous pemphigoid. Management for<unk>  has seen limited success in treating the syndrome by bone marrow transplantation.
IPEX syndrome
EAST syndrome
TAN syndrome
TEMPI syndrome
SUNCT syndrome
VEXAS syndrome
3C syndrome
RIDDLE syndrome