Granulation tissue with a poorly formed granuloma to the left of centre. Within this area there is a multinucleate<unk>  cell of the<unk>  type. The patient had a healing mycobacterial infection of the skin (M. ulcerans infection).<unk> s are large cells found in granulomatous conditions. They are formed by the fusion of epithelioid cells (macrophages), and contain nuclei arranged in a horseshoe-shaped pattern in the cell periphery. Although traditionally their presence was associated with tuberculosis, they are not specific for tuberculosis or even for mycobacterial disease. In fact, they are found in nearly every form of granulomatous disease, regardless of etiology.
Langhans giant cell
Touton giant cell
Nevus cell
Aschoff cell
Koilocyte
Hürthle cell
Tingible body macrophage
Epithelioid cell