In diseases such as hemolytic uremic syndrome, disseminated intravascular coagulation, thrombotic thrombocytopenic purpura, and malignant hypertension, the endothelial layer of small vessels is damaged with resulting fibrin deposition and platelet aggregation. As red blood cells travel through these damaged vessels, they are fragmented resulting in intravascular hemolysis. The resulting schistocytes (red cell fragments) are also increasingly targeted for destruction by the reticuloendothelial system in the spleen, due to their narrow passage through obstructed vessel lumina. It is seen in systemic lupus erythematosus, where immune complexes aggregate with platelets, forming intravascular thrombi.<unk>  is also seen in cancer.<unk>  may be suspected based on routine medical laboratory tests such as a CBC (complete blood cell count). Automated analysers (the machines that perform routine full blood counts in most hospitals) are designed to flag blood specimens that contain abnormal amounts of red blood cell fragments or schistocytes.
Microangiopathic hemolytic anemia
Mixed autoimmune hemolytic anemia
Myomatous erythrocytosis syndrome
Acquired hemolytic anemia
Autoimmune hemolytic anemia
Mechanical hemolytic anemia
Refractory anemia with excess of blasts
Drug-induced nonautoimmune hemolytic anemia