<unk>  is an important protease enzyme that when expressed aberrantly can cause emphysema or emphysematous changes. This involves breakdown of the lung structure and increased airspaces. Mutations of the ELANE gene cause cyclic and severe congenital<unk> utropenia, which is a failure of<unk> utrophils to mature. In 2019 study was confirmed that ELANE deletion does not cause<unk> utropenia.
Neutrophil elastase
Fibrinolysin
Alpha defensin
Beta defensin
Complement component 5a
Complement component 3
Complement component 4
Intrinsic factor