Compared to<unk> ,<unk>  exhibits significantly higher in vitro and in vivo activity in several models of human cancer. A preclinical study, performed at Dana–Farber Cancer Institute, demonstrated that<unk>  induced apoptosis in multiple myeloma cell lines, even those resistant to conventional treatment (including<unk> . In vivo effects in xenografted animals were also observed, and the results confirmed by M Chesi and co-workers – in a unique genetically engineered mouse model of multiple myeloma – are believed to be predictive of clinical efficacy.
Melphalan flufenamide
Normustine
Ifosfamide
Fluorouracil
Carmustine
GemOx
Topotecan
Etoposide