Environmental and genetic factors are involved in the pathophysiology of high LDL.  Several conditions may contribute to the pathophysiology of high LDL, such as diet high in saturated fat, hypothyroidism, nephrotic syndrome, pregnancy, obesity, or medications such as amiodarone, cyclosporine, diuretics, and glucocorticoids.  Abnormally low LDL can occur, and they usually result from rare inherited conditions, such as familial hypobetalipoproteinemia, abetalipoproteinemia, Anderson's disease (chylomicron retention disease), familial combined hypolipidemia, and PCSK9 mutations.
Low density lipoprotein pathophysiology
High density lipoprotein pathophysiology
Hypolipoproteinemia pathophysiology
Low density lipoprotein physiology
Very low density lipoprotein physiology
Thrombophilia pathophysiology
High density lipoprotein physiology
Atherosclerosis pathophysiology