Genetic and environmental factors play a key role in the pathogenesis of<unk> 's<unk> . Mutations in the CARD15 gene (also known as the NOD2 gene) are associated with<unk> 's<unk>  and with susceptibility to certain phenotypes of<unk>  location and activity. Environmental factors include autoimmune<unk>  and dysregulated Immune Response to Commensal Bacteria. Characteristic features of the pathology that point toward<unk> 's<unk>  are transmural pattern of inflammation and skip lesions. Under microscopy Granulomas are seen, which are aggregates of macrophage derivatives known as giant cells, are found in 50% of cases and are most specific for<unk> 's<unk> .
Crohn's disease pathophysiology
Stomatitis pathophysiology
Gastritis pathophysiology
Dyspepsia pathophysiology
Irritable bowel syndrome pathophysiology
Ulcerative colitis pathophysiology
H.pylori gastritis pathophysiology
Meckel's diverticulum pathophysiology