Echocardiography/ultrasound may be helpful raising the suspicion of<unk>  sclerosis.
Tuberous sclerosis echocardiography or ultrasound
Cretinism echocardiography or ultrasound
Neurofibromatosis type 1 physical examination
Hunter syndrome physical examination
Cowden syndrome MRI
Tuberous sclerosis MRI
Down syndrome echocardiography or ultrasound
Lutembacher's syndrome echocardiography