Hashimoto's thyroiditis (HT) is characterized by lymphocytic infiltration of the thyroid gland and production of antibodies that recognize thyroid-specific antigens. The pathogenesis is not yet completely understood. Thyroid cells undergo atrophy or transform into a type of follicular cell rich in mitochondria called Hurthle cell. It is currently thought that the disease is caused by abnormalities in cellular and humoral immunity which results in a localized cell-mediated immune response directed toward the thyroid parenchymal cells. This results in the decreased production of thyroid hormones.
Hashimoto's thyroiditis pathophysiology
De Quervain's thyroiditis pathophysiology
Silent thyroiditis pathophysiology
Medullary thyroid cancer pathophysiology
Thyroid adenoma pathophysiology
Hashimoto's thyroiditis epidemiology and demographics
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Follicular thyroid cancer risk factors