text: A<unk>  (sometimes known as an orphan disease) has such a low prevalence in a population that a doctor in a busy general practice would not expect to see more than one case a year.<unk> s, including those of genetic origin, are life-threatening or chronically debilitating diseases which are of such low prevalence that special combined efforts are needed to address them.
option_0: Rare disease
option_1: Minimal change disease risk factors
option_2: Chronic renal failure causes
option_3: Osteoporosis causes
option_4: Congestive heart failure pathophysiology
option_5: Coronary heart disease causes
option_6: Chronic renal failure pathophysiology
option_7: Spinal muscular atrophy risk factor