text: Patients with<unk>  usually appear asymptomatic at the beginning of the disease. Physical examination of patients with<unk>  is usually remarkable for jaundice, dry skin, large fontanelles, macroglossia, umbilical hernia, bradycardia, delayed puberty, and hypotonia.
option_0: Cretinism physical examination
option_1: Hurler syndrome physical examination
option_2: Noonan syndrome physical examination
option_3: Cowden syndrome physical examination
option_4: Hunter syndrome physical examination
option_5: Progeria physical examination
option_6: Peutz-Jeghers syndrome physical examination
option_7: Asperger syndrome physical examination