text: <unk> , or<unk> s of<unk> , are a new group of pharmaceuticals that are used primarily in treatment of hypertension.
  They act on the juxtaglomerular cells of kidney, which produce<unk>  in response to decreased blood flow.
option_0: Renin inhibitor
option_1: Aldosterone antagonist
option_2: Adrenergic agonist
option_3: Protein kinase inhibitor
option_4: COX-2 inhibitor
option_5: Beta-adrenergic agonist
option_6: PDE-5 inhibitor
option_7: Dipeptidyl peptidase-4 inhibitor