text: In patients with pancreatic cancer, surgery is the primary modality of treatment. However, surgery is performed only in a small fraction of patients who have resectable lesions.  Majority of patients have unresectable disease and are treated with chemotherapy and/or radiation<unk>  as a part of adjuvant or neoadjuvant<unk> .  Curative resection is not performed in cases of extrapancreatic involvement that require palliative<unk> .  As per the guidelines of The National Comprehensive Cancer Network (NCCN), patients with locally advanced unresectable or metastatic disease should be treated with a combination of Leucovorin, 5-fuorouracil, Oxaliplatin, and Irinotecan also known as FOLFIRINOX regimen. Neoadjuvant<unk>  is preferred as shrinkage of the tumor using chemotherapy makes resection easier and improves patient prognosis. Radiotherapy may also form part of neoadjuvant<unk>  to facilitate tumor shrinkage, but its use on unresectable tumors remains controversial.
option_0: Pancreatic cancer medical therapy
option_1: Pancreatic cancer chemotherapy
option_2: Pancreatic cancer radiation therapy
option_3: Pancreatic cancer surgery
option_4: Stomach cancer medical therapy
option_5: Gallbladder cancer medical therapy
option_6: Fatty liver medical therapy
option_7: Hereditary pancreatitis medical therapy