text: Pernicious anemia (also called Addison's anemia) is a type of red blood cell disorder caused by impaired vitamin B12 metabolism. Vitamin B12 is primarily absorbed by the small intestine, after being bound to intrinsic factor secreted by parietal cells of gastric mucosa. When this process is disrupted by conditions like atrophic gastritis, celiac disease, small bowel resection etc, B12 deficiency ensues.<unk>  therapies for chronic<unk>  leukemia (CML) include tyrosine kinase inhibitors, chemotherapy, stem cell transplant, and/or biological therapy. Improved understanding of the nature of the BCR-ABL protein and its action as a tyrosine kinase, targeted therapies have been developed (the first of which was imatinib mesylate) which specifically inhibit the activity of theBCR-ABL protein. These tyrosine kinase inhibitors can induce complete remissions in chronic<unk>  leukemia, confirming the central importance of BCR-ABL as the cause of chronic<unk>  leukemia. In patients with blast phase CML, cytotoxic chemotherapy is usually indicated.
option_0: Chronic myelogenous leukemia medical therapy
option_1: Acute myeloid leukemia medical therapy
option_2: Chronic lymphocytic leukemia medical therapy
option_3: Acute lymphoblastic leukemia medical therapy
option_4: Myeloproliferative neoplasm medical therapy
option_5: Acute promyelocytic leukemia medical therapy
option_6: Myelodysplastic syndrome medical therapy
option_7: Hairy cell leukemia medical therapy