text: <unk>  involves an act that reduces the activation or efficacy of the immune system. Some portions of the immune system itself have immuno-suppressive effects on other parts of the immune system, and<unk>  may occur as an adverse reaction to treatment of other conditions.
  In general, deliberately induced<unk>  is performed to prevent the body from rejecting an organ transplant, treating graft-versus-host disease after a bone marrow transplant, or for the treatment of auto-immune diseases such as rheumatoid arthritis or Crohn's disease. This is typically done using drugs, but may involve surgery (splenectomy), plasmapharesis, or radiation.
  A person who is undergoing<unk> , or whose immune system is weak for other reasons (for example, chemotherapy and HIV), is said to be immunocompromised. An immunosuppressant is any agent that causes<unk> , including immunosuppressive drugs such as Carglumic acid and some environmental toxins.
option_0: Immunosupression
option_1: Transplant rejection
option_2: Anaplerotic reactions
option_3: Desensitization 
option_4: Osteostimulation
option_5: Autoimmunity
option_6: Bone marrow suppression
option_7: Ototoxicity