text: <unk>  is the<unk>  that occurs due to destruction of the red blood cells either intravascularly or extravascularly. Extravascular<unk>  is more common than the intravascular<unk> .<unk>  may be acquired or inherited due to enzyme defects that lead to the RBCs hemolysis. Pathophysiology of most<unk>  involves two mechanisms of red blood cells hemolysis either complement activated autoantibodies or non complement activated autoantibodies. Various drugs ,as anti cancer drugs, also lead to immune-mediated hemolysis. Red blood cell membrane and enzyme defects is the main cause of non immune mediated hemolysis. The causes of the<unk>  include intrinsic and extrinsic factors.<unk>  must be differentiated from other conditions that affect the RBCs as nutritional deficiencies and thalassemias.<unk>  is a relatively rare condition. The incidence and prevalence are fairly low. The risks factors of<unk>  can be categorized as oxidative stress, mechanical injury, and genetic conditions.  The natural history of<unk>  depend on the underlying cause of<unk> , some types of<unk>  with good prognosis and others<unk> ve poor prognosis. Symptoms and physical examination of<unk>  are reflecting the RBCs hemolysis, hemoglobin break down, and the release of their products in the circulation. Jaundice, hepatomegaly, and splenomegaly are the most common signs are seen in<unk> . Serum tests include LDH,<unk> ptoglobin, bilirubin, and reticulocyte count are important in the diagnosis of<unk> . CT scan, MRI scan, and ultrasound imaging can be helpful in assessment of the splenomegaly in cases of<unk> . Typical treatment of<unk>  include corticosteroids or non-steroidal immunosuppressants. Splenectomy is the second line of treatment of<unk> .
option_0: Hemolytic anemia
option_1: Non immune hemolytic anemia
option_2: Immune hemolytic anemia
option_3: Sideroblastic anemia
option_4: Basophilia
option_5: Achrestic anemia
option_6: Megaloblastic anemia
option_7: Warm autoimmune hemolytic anemia