text: <unk>  is the second most common type of congenital adrenal hyperplasia. Gene mutations are the cause of these diseases. Mutations in the CYP11B1 gene cause this disorder. CYP11B1 gene provides instructions for making an enzyme called steroid<unk> -hydroxylase, which enables the adrenal glands to convert cholesterol into other steroid hormones. Patients with<unk> , the adrenal glands typically don't produce enough cortisol. Deficiency of<unk> -hydroxylase can interfere with normal growth and development in children and adults. Usual signs and symptoms include girls' external appearance change, boys may have 3-4 years early virilizing characteristics than the normal. Serum and urinary hormone level can help the diagnosis. Steroid therapy and surgery to correct the appearance and function of the genitals are the main treatments. Many patients with<unk>  can lead normal lives with proper treatment. Infants with untreated adrenal crisis may die within several weeks after birth.
option_0: 11β-hydroxylase deficiency
option_1: 21-hydroxylase deficiency
option_2: 17 alpha-hydroxylase deficiency
option_3: 3 beta-hydroxysteroid dehydrogenase deficiency
option_4: 17-beta-hydroxysteroid dehydrogenase deficiency
option_5: 18-Hydroxylase deficiency
option_6: 5-alpha-reductase deficiency
option_7: 21-Hydroxylase Deficiency