text: People with<unk>  generally don't experience signs or symptoms. Some people may experience a rash or nerve problems, such as numbness or tingling.<unk>  is usually detected by chance when you have a blood test for another condition.<unk>  occurs when abnormal plasma cells produce M protein. The protein isn't harmful for most people. But if too much M protein accumulates, it crowds out healthy cells in your bone marrow and can damage other tissues in your body. There is no specific treatment options for<unk>  ; the mainstay of therapy is supportive care, keep an eye and delay the progression to other plasma dyscrasias.Trials using lenalidomide and bisphosphonates are been run to determine whether they decrease they progression of the disease both for<unk>  and multiple myeloma. Vitamin D and calcium can be given as anti-resorptive therapy. Corticosteroids may be help with peripheral neuropathy. Complications include fractures specially in lumbar vertebrae, thromboembolic phenomena, hypercoaguable state, and development of secondary cancers eg. acute myeloid leukemia and myelodysplastic syndromes.
option_0: Monoclonal gammopathy of undetermined significance
option_1: Monoclonal gammopathy of renal significance
option_2: Familial renal amyloidosis
option_3: Familial amyloidosis
option_4: Multiple myeloma
option_5: POEMS syndrome
option_6: Waldenström's macroglobulinemia
option_7: Secondary amyloidosis