text: <unk> <unk>  Hyperlipoproteinemia (HLP V) is a rare disorder of lipo-protein metabolism characterized by fasting chylomicronemia and elevated levels of cholesterol in the very low density (VLDL) lipoprotein fraction. The triglyceride(TG) levels are invariably greater than 1000mg/dl thereby increasing the risk of pancreatitis.It has been postulated that HLP V is the result of a defective clearance of TG-rich lipoproteins(VLDLs and Chylomicrons),although lipoprotein lipase is not completely absent. Another suggested mechanism is of VLDL TG's overproduction. Some patients seem to have "Primary" HLP V which usually appears first in adulthood,this phenotype is often associated with secondary factors,almost always Diabetes Mellitus.May be associated with Eruptive Xanthomas and Hyperuricemia. The primary goal of therapy is to reduce the TG level to <500mg/dl for the intent of reducing the risk of pancreatitis.
option_0: Hyperlipoproteinemia type 5
option_1: Hyperlipoproteinemia type II
option_2: Primary hypertriglyceridemia
option_3: Apolipoprotein B deficiency
option_4: Familial combined hyperlipidemia
option_5: Familial hypercholesterolemia
option_6: Gaucher's disease
option_7: Abetalipoproteinemia