text: <unk>  is a rare disease due to congenital adrenal hyperplasia. It is characterized by impaired biosynthesis pathway of progestins, mineralocorticoids, glucocorticoids, and androgens. As a result of cortisol absence, corticotropin (ACTH) secretion increases and leads to produce<unk> -hydroxy-delta-5-steroids pregnenolone, 17-hydroxypregnenolone, and dehydroepiandrosterone (DHEA), also their sulfates. In peripheral tissues the conversion of DHEA sulfate (DHEAS) to testosterone, is responsible for virilization in females.<unk>  is caused by a mutation in the HSD3B2 gene. Symptoms of<unk>  may include symptoms of both cortisol and aldosterone deficiency such as feeding difficulties, vomiting, volume depletion, undervirilization in newborn males, and mild virilization and clitoromegaly in newborn female. Diagnosis for<unk>  is based on delta-5-17-hydroxypregnenolone high levels in serum laboratory tests. The mainstay of therapy for this disease is hydrocortisone and fludrocortisone acetate. The reconstruction surgery for ambiguous genitalia in genetically male patients may be applied.
option_0: 3 beta-hydroxysteroid dehydrogenase deficiency
option_1: 17-beta-hydroxysteroid dehydrogenase deficiency
option_2: 17 alpha-hydroxylase deficiency
option_3: 21-hydroxylase deficiency
option_4: 11β-hydroxylase deficiency
option_5: 18-Hydroxylase deficiency
option_6: 5-alpha-reductase deficiency
option_7: 21-Hydroxylase Deficiency