text: <unk>  is a rare, systemic infectious<unk>  caused by the bacterium Tropheryma<unk> i. Tropheryma<unk> i is usually transmitted through oral route to human hosts. Impaired macrophage function and cellular immunity are the main factors in replication of the bacteria and<unk>  expansion to every tissue. Following contamination, based on immunologic response, patient might present with different manifestations including acute infection, asymptomatic carrier state, the classic<unk> , and localized chronic infection. Individuals with positive HLA-B27 and defective cellular immunity including AIDS are at risk for<unk> .<unk>  primarily causes malabsorption but may affect any part of the body including the heart, lungs, brain, joints, and eyes. Diagnostic findings of<unk>  include PAS positive inclusions in macrophages of lamina propria. Endoscopy and small bowel biopsy may be helpful in the diagnosis of<unk> . Antimicrobial therapy is the mainstay of therapy for<unk> .
option_0: Whipple's disease
option_1: Hereditary pancreatitis
option_2: Zollinger-Ellison syndrome
option_3: Choledocholithiiasis
option_4: Weber–Christian disease
option_5: Kienbock's disease
option_6: Ménétrier's disease
option_7: Giardiasis