text: <unk><unk>  usually develops in the setting of chronic inflammation of the<unk> .The most common source of chronic inflammation is cholesterol gallstones. The<unk><unk>  risk increases to 4-5% in the presence<unk><unk>  (GBC) is the result of 2 or more different biological pathways based on morphological, genetic, and molecular evidence. Metaplasia is believed to be one of the pathological reason behind the development of<unk>  carcinoma. Although the definite relationship between metaplasia and dysplasia, is not clearly established yet. On gross pathology, fibrosis and thickening of  the<unk>  are characteristic findings of the<unk><unk> . On microscopic histopathological analysis, outer portion is often better differentiated than deeper portion are characteristic findings of<unk><unk> .
option_0: Gallbladder cancer pathophysiology
option_1: Choledocholithiasis pathophysiology
option_2: Chronic cholecystitis pathophysiology
option_3: Chronic pancreatitis pathophysiology
option_4: Ascending cholangitis pathophysiology
option_5: Cholangitis pathophysiology
option_6: Cholangiocarcinoma risk factors
option_7: Cholangiocarcinoma pathophysiology