text: Genetic and environmental factors play a key role in the pathogenesis of<unk> 's<unk> . Mutations in the CARD15 gene (also known as the NOD2 gene) are associated with<unk> 's<unk>  and with susceptibility to certain phenotypes of<unk>  location and activity. Environmental factors include autoimmune<unk>  and dysregulated Immune Response to Commensal Bacteria. Characteristic features of the pathology that point toward<unk> 's<unk>  are transmural pattern of inflammation and skip lesions. Under microscopy Granulomas are seen, which are aggregates of macrophage derivatives known as giant cells, are found in 50% of cases and are most specific for<unk> 's<unk> .
option_0: Crohn's disease pathophysiology
option_1: Stomatitis pathophysiology
option_2: Gastritis pathophysiology
option_3: Dyspepsia pathophysiology
option_4: Irritable bowel syndrome pathophysiology
option_5: Ulcerative colitis pathophysiology
option_6: H.pylori gastritis pathophysiology
option_7: Meckel's diverticulum pathophysiology