text: <unk>  is a rare disease characterised by chronic hives (urticaria) and periodic fever, bone pain and joint pain (sometimes with joint inflammation), weight loss, malaise, fatigue, swollen lymph glands and enlarged spleen and liver.
  The urticarial rash is non-itching in more than half of cases, which is unusual for hives. It is most prominent on the trunk, arms and legs, sparing the palms, soles, head and neck. Associated angioedema has been reported in a few patients. A review of 94 cases found a mean age at onset of 51 years, and only four patients developed symptoms before the age of 35. The cause and disease mechanism of<unk>  remain largely unknown.<unk>  is considered an autoimmune disorder. Chronic hives and a monoclonal gammopathy have been proposed as the major criteria, while the others represent minor criteria.
option_0: Schnitzler syndrome
option_1: Bloom syndrome
option_2: Plummer-Vinson syndrome
option_3: Tropical sprue
option_4: Carvajal-Huerta syndrome
option_5: Mirizzi's syndrome
option_6: Hartnup Disease
option_7: Zenker's diverticulum