text: Normally, in human embryos, the closure of the<unk> <unk>  occurs around the 30th day after fertilization. However, if something interferes and the<unk>  fails to close properly, a<unk> will occur.
  The incidence of<unk>  is 2.6 in 1,000 worldwide.
option_0: Neural tube defects
option_1: Craniofacial anomalies
option_2: Anorectal anomalies
option_3: Fetal distress
option_4: Intrauterine growth retardation
option_5: Growth failure
option_6: Small for gestational age
option_7: Hydrocephalus