text: <unk> s, or<unk> s, are molecules<unk>  with groups of<unk> s, that are recognized by cells of the innate immune system. These molecules can be referred to as small<unk>  motifs conserved within a class of microbes. They are recognized by Toll-like receptors (TLRs) and other<unk>  recognition receptors (PRRs) in both plants and animals.
  They activate innate immune responses, protecting the host from infection, by identifying some conserved non-self molecules. Bacterial Lipopolysaccharide (LPS), an endotoxin found on the bacterial cell membrane of a bacterium, is considered to be the prototypical<unk> . LPS is specifically recognised by TLR 4, a recognition receptor of the innate immune system. Other<unk> s include bacterial flagellin (recognized by TLR 5), lipoteichoic acid from Gram positive bacteria, peptidoglycan, and nucleic acid variants normally<unk>  with viruses, such as double-stranded RNA (dsRNA), recognized by TLR 3 or unmethylated CpG[disambiguation needed] motifs, recognized by TLR 9.  Although the term "PAMP" is relatively new, the concept that molecules derived from microbes must be detected by receptors from multicellular organisms has been held for many decades, and references to an "endotoxin receptor" are found in much of the older literature.
  The term "PAMP" has been criticized on the grounds that most microbes, not only<unk> s, express the molecules detected; the term microbe-associated<unk><unk> , or MAMP, has therefore been proposed. A virulence signal capable of binding to a<unk>  receptor, in combination with a MAMP, has been proposed as one way to constitute a<unk> -specific)<unk> .  Plant immunology frequently treats the terms "PAMP" and "MAMP" interchangeably, considering their recognition to be the first step in plant immunity, PTI <unk> -triggered immunity), a relatively weak immune response that occurs when the host plant does not also recognize<unk> ic effectors which damage it or modulate its immune response.
option_0: Pathogen-associated molecular pattern
option_1: Neurotoxin
option_2: Antimicrobial peptides
option_3: Pneumolysin
option_4: Immunotoxin
option_5: Chlorotoxin
option_6: Enterotoxin
option_7: Tumor antigen