text: The pathophysiology of<unk> <unk>  disease is based on a mutation in the beta-globin chain of hemoglobin, which leads to red blood<unk> <unk> ng and vaso-occlusive crises.
option_0: Sickle-cell disease pathophysiology
option_1: Starvation pathophysiology
option_2: Sickle-cell disease epidemiology and demographics
option_3: Sickle-cell disease risk factors
option_4: Cardiomyopathy pathophysiology
option_5: Cryoglobulinemia pathophysiology
option_6: Statin induced myopathy pathophysiology
option_7: Evans syndrome pathophysiology