text: Environmental and genetic factors are involved in the pathophysiology of high LDL.  Several conditions may contribute to the pathophysiology of high LDL, such as diet high in saturated fat, hypothyroidism, nephrotic syndrome, pregnancy, obesity, or medications such as amiodarone, cyclosporine, diuretics, and glucocorticoids.  Abnormally low LDL can occur, and they usually result from rare inherited conditions, such as familial hypobetalipoproteinemia, abetalipoproteinemia, Anderson's disease (chylomicron retention disease), familial combined hypolipidemia, and PCSK9 mutations.
option_0: Low density lipoprotein pathophysiology
option_1: High density lipoprotein pathophysiology
option_2: Hypolipoproteinemia pathophysiology
option_3: Low density lipoprotein physiology
option_4: Very low density lipoprotein physiology
option_5: Thrombophilia pathophysiology
option_6: High density lipoprotein physiology
option_7: Atherosclerosis pathophysiology