text: <unk>  is defined as a lymphoma of follicle center B-cells (centrocytes and centroblasts). It is a type of non Hodgkin's lymphoma.<unk>  is caused by translocation between the chromosomes 14 and 18 that results in the overexpression of the BCL-2 gene. The progression to<unk>  involves the microRNAs (miRNAs).On microscopic histopathological analysis, centrocytes and centroblasts are the characteristic findings of<unk> .<unk>  may be classified according to WHO criteria into 3 subtypes: low grade<unk> , high grade<unk>  and diffuse large B cell lymphoma. The prevalence of<unk>  increases with age. Women are more commonly affected with<unk>  than men. The prognosis is generally poor and the 5-year survival rate is approximately 72-77%. The most common symptoms of<unk>  include fever, weight loss, night sweats, skin rash, painless swelling in the neck, axilla, groin, thorax, and abdomen, and chest pain, abdominal pain, and bone pain. Common physical examination findings of<unk>  include fever, rash, splenomegaly, peripheral lymphadenopathy, central lymphadenopathy, chest tenderness, abdominal tenderness, and bone tenderness. Laboratory tests for  the diagnosis of<unk>  include lymph node biopsy, complete blood count (CBC), blood chemistry studies, cytogenetics studies,<unk> ow cytometry, immunohistochemistry, FISH, genetic testing, and immunophenotyping. CT, MRI, and PET may be helpful in the diagnosis and assessing the spread of<unk> . Other diagnostic studies for the diagnosis of<unk>  include bone marrow aspiration and biopsy, laparoscopy, and laparotomy. The optimal therapy for<unk>  depends on the stage at diagnosis, age, and prognostic scores. The predominant therapy for<unk>  is chemotherapy. Adjunctive hematopoietic stem cell transplantation, and radioimmunotherapy may be required.
option_0: Follicular lymphoma
option_1: Nodal marginal zone lymphoma
option_2: Thymic carcinoma
option_3: Diffuse large B cell lymphoma
option_4: AIDS-related lymphoma
option_5: Lymphoplasmacytic lymphoma
option_6: B-cell lymphoma
option_7: Anaplastic large cell lymphoma