text: <unk><unk>  C (APC)<unk>  occurs when APC fails to inactivate downstream coagulation factors, specifically Factor V and Factor VIII. This hemostatic disorder may be caused by either acquired, inherited, or a combination of both conditions. The factor V Leiden (FVL) mutation is the best known hereditary form accounts for more than 95 percent of cases of hereditary<unk><unk> , and acquired forms occur in the presence of elevated Factor VIII concentrations or conditions like hormone replacement therapy and pregnancy. These conditions contribute to the increased risk of hypercoagulable state and thrombosis. It has been estimated that up to 64% of patients with venous thromboembolism might have<unk> .
option_0: Activated protein C resistance
option_1: Protein C deficiency
option_2: Factor XIII deficiency
option_3: Antithrombin III deficiency
option_4: Protein S deficiency
option_5: Factor V Leiden
option_6: Glanzmann's thrombasthenia pathophysiology
option_7: Congenital protein C or S deficiency