Biocompatibilities of organic solvents with Lactobacillus delbrueckii.
In the search for biocompatible extractants for extractive fermentation of lactic acid, the effect of twelve organic solvents on the activity of L. delbrueckii were studied at different concentration levels. On this basis, the compatibilities of twelve solvents with L. delbrueckii were summarized into four classes: completely compatible, compatible at molecular level, partially compatible and non-compatible. The characteristics were described qualitatively for each class in terms of relative values between the solubility of organic solvent in water (Cs) and the toxicity of organic solvent, which is indicated by a newly defined concentration parameter (Cm). The classification was helpful for the selection of extractant in extractive fermentation.