Changes in the gonads, reproduction and generations of white rats under the effect of some pesticides.
The problems of the gonadotropic effect of pesticides, together with changes in reproduction and in the offspring are of great interest and have drawn the attention of scientists during recent years. Assessment of these aspects should be made on the basis of integrated toxicological tests (weight, behaviour, mortality, fertility, etc.). They should be completed by some biochemical studies on homogenates of the testes (determination of RNA and DNA, as well as of enzyme systems which might relative to the metabolic processes in the sex tissue, according to the chemical nature of the examined noxa). These studies should be carried out in the parent generation (F0), directly exposed to chemical agents. The following generations, (F1-F3), not exposed to the agent, are submitted to the same analyses. with regard to the full assessment of the offspring some evaluation of the functional state of given organs (liver, brain, testes) might be performed.