sRAGE Concentration İncreases Following the Treatment of Severe Diabetic Ketoacidosis
To determine the time relationships of sRAGE, (a decoy of the AGE-RAGE axis) and D-lactate, (a metabolite of methylglyoxal) in the inflammatory response of DKA. We also determined if RAGE is expressed in the myocardium of a newly diagnosed and untreated young person with fatal T1D/DKA. 16 children and adolescents with T1D had blood samples obtained 6-12 hours into treatment; at 3 weeks; and 3 months post treatment. sRAGE and D-lactate at 3 months were baseline. sRAGE during treatment was 39% lower than the values at 2 weeks (p =.0036) and at 3 months (p= .0023) post treatment. D-lactate was higher during treatment than at 3 weeks (p = .04) and at 3 months (p=0.035). sRAGE is decreased during treatment compared to concentrations at 2 weeks, and at 3 months post- treatment.The increased D-lactate during treatment is in keeping with the known increased dicarbonyls at this time. The RAGE expression in a young myocardium prior to DKA treatment supports cardiovascular inflammation pre-treatment and at a young age.