Development of a novel high quantum efficiency MV x-ray detector for image-guided radiotherapy: A feasibility study.
To develop a new scintillating fiber-based electronic portal imaging device (EPID) with a high quantum efficiency (QE) while preserving an adequate spatial resolution. Two prototypes were built: one with a single pixel readout and the other with an active matrix flat-panel imager (AMFPI) for readout. The energy conversion layer of both prototypes was made of scintillating fiber layers interleaved with corrugated lead sheets to form a honeycomb pattern. The scintillating fibers have a diameter of 1 mm and the distance between the centers of neighboring fibers on the same layer is 1.35 mm. The layers have 1.22 mm spacing between them. The energy conversion layer has a thickness of 2 cm. The modulation transfer function (MTF), antiscatter properties and sensitivity of the detector with a single pixel readout were measured using a 6-MV beam on a LINAC machine. In addition, a Monte Carlo simulation was conducted to calculate the zero-frequency detective quantum efficiency (DQE(0)) of the proposed detector with an active matrix flat-panel imager for readout. The DQE(0) of the proposed detector can be 11.5%, which is about an order of magnitude higher than that of current EPIDs. The frequency of 50% modulation ( f 50 ) of the measured MTF is 0.2 mm - 1 at 6 MV, which is comparable to that of video-based EPIDs. The scatter to primary ratio (SPR) measured with the detector at 10 cm air gap and 20 × 20 cm 2 field size is approximately 30% lower than that of ionization chamber-based detectors with a comparable QE. The detector noise which includes the x-ray quantum noise and absorption noise is much larger than the electronic noise per pixel of the flat-panel imager at a dose of less than two LINAC pulses. Thus, the proposed detector is quantum noise limited down to very low doses (∼a couple of radiation pulses of the LINAC). A proof-of-concept image has been obtained using a 6-MV beam. This work indicates that by using scintillating fibers and lead layers it is possible to increase the thickness of the detecting materials, and therefore the QE or the DQE(0) of the detector, while maintaining an adequate spatial resolution for MV x-ray imaging. Due to the use of lead as the spacing material, the new detector also has antiscatter property, which will help improve the signal-to-noise ratio of the images. Further investigation to optimize the design of the detector and achieve a better combination of DQE and spatial resolution is warranted.