Impact of improved glycemic control on quality of life in patients with diabetes.
To review the current literature that examines the effects of diabetes on the health-related quality of life (HRQOL). Three key diabetes-specific HRQOL survey instruments are described and reviewed. In addition, the findings in several recent studies that have assessed the effects of diabetes on HRQOL are discussed. Although the medical benefits of improved glycemic control in diabetes have gained wide recognition, less attention has been paid to the effects of diabetes on HRQOL. Both generic and diabetes-oriented measures can be used to evaluate HRQOL. Numerous studies have shown that diabetes is associated with significant reductions in HRQOL. In particular, diabetes-related complications lead to diminished quality of life. Use of intensive diabetes treatment does not appear to reduce HRQOL, and alternative therapeutic strategies, as well as education and support, may benefit the quality of life in patients with diabetes. Early and aggressive intensive therapy leading to improved glycemic control is likely to reduce the impact of diabetes on the HRQOL, by slowing the onset and progression of complications.