Homozygosity for 8pter----q22 in acute myeloblastic leukemia with t(8;21)(q22;q22).
A case of acute nonlymphocytic leukemia with homozygosity for the chromosome segment 8pter----8q22 is reported. A t(8;21)(q22;q22) translocation was associated with duplication of the derivative chromosome 8q- and absence of the normal chromosome 8. These rearrangements also yielded hemizygosity for 8q22----qter. This case shows that acquired hemizygosity and homozygosity do exist in leukemia as in solid malignant tumors.