[Expression and significance of human leukocyte antigen DR and intercellular adhesion molecule-1 in normal and pathological corneas].
To study the expression of human leukocyte antigen DR (HLA-DR) and intercellular adhesion molecule-1 (ICAM-1) in normal and pathological corneas and their significance in corneal inflammation and rejection after keratoplasty. The expression of HLA-DR and ICAM-1 were detected in 10 normal corneas and 48 pathological corneas by using immunohistochemical techniques. HLA-DR and ICAM-1 were not expressed or only slightly expressed in normal corneas and markedly expressed in pathological corneas, especially in inflammatory corneas. In general, HLA-DR and ICAM-1 were co-expressed in similar regions. The expression rates of HLA-DR and ICAM-1 in the 7 cases of keratoplasty rejection were higher than that in the 21 cases of non-rejection. The overexpression of HLA-DR and ICAM-1 is related to corneal inflammation and can promote the occurrence of keratoplasty rejection.