A projection linking motor cortex with the LM-suprageniculate nuclear complex through the periaqueductal gray area which surrounds the nucleus of Darkschewitsch in the cat.
Whereas a previous study by one of us (Hicks et al., 1986) suggested that periaqueductal gray (PAG) neurons projecting to the lateralis medialis-suprageniculate (LM-SG) complex might mediate transmission of affective-related nociceptive information, our present work suggests instead, a function in processes related to movement. Cells of the nucleus of Darkschewitsch (ND) are known to have reciprocal projections with the motor cortex (MX), in particular with the hand area of MX, and also to project to the rostral medial accessory olivary (MAO) nucleus (Onodera and Hicks, 1995a). That the ND might be related to saccadic oculomotor function, as well as to the control of hand movements through its connections via the olivo-cerebellar circuit, is indicated by the fact that ND receives a strong projection from the substantia nigra pars reticulata and zona incerta (SNR/ZI) and projects directly and/or indirectly to eye movement nuclei (Onodera and Hicks, 1995b). Thus, ND may function in permitting integration of eye-hand motor coordination. This study focussed on the area of PAG surrounding ND. WGA-HRP was injected into MX and many labelled terminals and large neurones were in ND, with lesser numbers being observed in the area of the PAG surrounding ND. After injections into ND and closely adjacent areas, labelled terminals were observed sparsely distributed with a restricted area of the LM-SG complex. After injections into LM-SG area, small neuronal somata were seen in the area of the PAG surrounding ND, but no labelled somata were detected in ND. Thus if the cells of this PAG area, like those of ND, have similar functions owing to their common reciprocal connections with MX, then the small neurones in PAG projecting to LM-SG may constitute an important link in the circuitry subserving visual processing and/or the regulation of orienting movements of the hand, head and eye.