Potentiated chemotherapeutic activity of 3,6-diamino-10-methyl-acridinium by combination with glycine or DL-alpha-alanine on the Ehrlich carcinoma.
Glycine or DL-alpha-alanine potentiated the chemotherapeutic action of 3,6-diaminoacridinium without increasing its toxicity when these amino acids were combined with it simultaneously. On the contrary, valine in combination with 3,6-diaminoacridinium diminished slightly the chemotherapeutic effect as compared to the monotherapy with 3,6-diaminoacridinium. The monotherapy with the applied amino acids in the same dosage showed no tumor inhibition.