Erythrocyte flow heterogeneity in the cerebrocortical capillary network.
The heterogeneity of erythrocyte flow velocity and erythrocyte flux and their dependence on decreased cerebral perfusion pressure were studied in the rat cerebral cortex using intravital video microscopy. With decreased perfusion pressure, both mean and range of erythrocyte flow velocity of individual capillaries was reduced. Both cell velocity and cell flux decreased more in high flow capillaries than in low flow capillaries. The results are compatible with the hypothesis that redistribution of capillary flow during hypotension may help to maintain the perfusion of arterio-venous capillary flow pathways. Although the data are preliminary, they represent the first direct measurements of capillary flow path length and transit time in the capillary network of the cerebral cortex.