Forget about thrombosis: Platelets and Alzheimer's disease, yet another sticky situation.
In this issue of Science Signaling, Donner et al define a highly interesting role for platelets in mediating the pathogenesis of Alzheimer's disease via a mechanism linked to integrin αIIbβ3 outside-in signaling and adenosine diphosphate release. These findings raise the intriguing prospect of harnessing antiplatelet drugs for disrupting the nexus between Aβ-induced activated platelets and Aβ fibril and aggregate formation.