Prediction of mammalian meiotic synaptic and recombinational behavior of inversion heterozygotes based on mitotic breakpoint data and the possible evolutionary consequences.
It has been suggested (Ashley, 1988) that it is possible to predict the meiotic behavior of chromosome aberrations of higher vertebrates based on the position of their breakpoints relative to mitotic band pattern. Evidence supporting this hypothesis and details of the expected synaptic, recombinational, and evolutionary effects of inversion with breakpoints in R-vs. G-bands are elaborated in the current paper.