Accelerated functional recovery after neuronal injury by P2 receptor blockade.
The effect of the P2 receptor antagonist pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS) on changes of the quantitative electroencephalogram (EEG) after injury of rat brain tissue was investigated. PPADS accelerated the functional recovery from microdialysis probe-induced disturbances in the nucleus accumbens by a decrease of the ratio of absolute slow (0.6-4 Hz) to fast (8-30 Hz) power, mainly caused by a decrease in the delta frequency power. These data provide evidence for a possible neuroprotective effect of P2 receptor antagonists in vivo.