Stroke in the fetus and neonate.
Multiple patterns of focal ischemic injury in the fetal and perinatal brain are now recognized as important causes of neurological disability in children. Strokes may be arterial or venous, symptomatic or subclinical, and can occur across multiple timeframes. Establishing the importance of an increasing number of potential risk factors and translating that knowledge into an improved understanding of pathophysiology are major challenges. Advanced neuroimaging has facilitated increased recognition of perinatal stroke and an improved understanding of plasticity mechanisms in the developing brain. Better outcome prediction will assist in patient selection for advancing neuroprotective strategies to reduce cerebral palsy and other adverse outcomes suffered by most children.