1. Field of the Invention
This invention relates to novel pharmaceutical compositions for the improvement of dysuria such as pollaki-uria or incontinence of urine. Dysuria is often caused by adult diseases such as cerebrovascular disorders and prostatic diseases, which results in not only serious hamper of the patients' action in their daily life but also impairment of the patients' dignity. On the other hand, it gives a great burden on the nursing family. As the world becomes more aged in population, and also from the viewpoint of quality of life, development of agents for the improvement of dysuria with more definite efficacy and higher safety is highly desired. The compositions according to the invention are useful as a therapeutic agent with higher safety in dysuria such as pollakiuria and incontinence of urine.
2. Description of the Prior Art
Pharmaceutical compositions for the treatment of pollakiuria and incontinence of urine in urology include cholinolytics, antimuscarinics and calcium antagonists. None of such composition may be satisfactory either in efficacy or in adverse reaction. For example, whereas, cholinolytics typical of which is butylscopolamine are observed to be inhibitory on cystic smooth muscles, their use is associated with disadvantages in that they are also highly active on other cholinergic viscera such as digestive tracts, cardiac muscles, sialaden and pupillary muscles. Since treatment for dysuria needs a long period of time for continued use of a drug even in aged patients, it should not only be therapeutically highly effective but also be highly safe.