U.S. Pat. Nos. 4,017,615, 3,888,995 and 3,592,930 pertain to ointment-like vehicle for corticosteroid drugs and the like.
References which disclose film formers as ingredients for topically administered dry formulations include U.S. Pat. Nos. 2,973,300, 3,214,338 and 4,210,633.
Bandage-like devices for delivering drugs topically or transdermally are described in U.S. Pat. Nos. 3,598,123, 4,191,743, 4,605,548, 4,655,768, 4,409,206, 4,286,592, 4,230,105, 3,948,254, 3,742,951, 3,734,097 and 3,731,683. Such devices may include separate adhesion and drug reservoir layers.
U.S. Pat. No. 3,536,809 discloses a mixture of a drug such as progesterone dispersed in a polyalkyleneglycol impregnated into a fabric strip which may be retained in the mouth to administer the drug through the buccal mucosa.
Considered more pertinent to the invention hereof are polymeric dispersion matrix materials which have skin adhesive properties and have a drug dispersed directed into the matrix.
In U.S. Pat. No. 3,632,740 it is suggested to incorporate a drug such as a corticosteroid into a pressure sensitive rubbery adhesive layer on a flexible backing.
In U.S. Pat. No. 4,292,301 there is disclosed a polymeric diffusion matrix said to permit sustained release of ephedrine, the matrix comprising a polar plasticizer such as glycerol or polyethylene glycol (MW 1000), polyvinyl alcohol, polyvinyl pyrrolidone and ephedrine.
U.S. Pat. No. 4,470,962 discloses a polymeric diffusion matrix said to be capable of sustained release of a drug comprising glycerol, polyvinylalcohol, a water soluble polymer with hydration sites, a drug dispersed therein and water.
U.S. Pat. Nos. 4,307,717 and 4,675,009 describe bandage materials which include a backing element and a substrate comprising a matrix material comprising a solid phase formed of a polysaccharide or certain synthetic polymers and a liquid phase consisting of a hydric alcohol, carbohydrates and/or proteins in an aqueous solution. The matrix material also contains a medicament suspended or dissolved therein.
U.S. Pat. No. 4,593,053 discloses polyvinylalcohol/polyvinyl pyrrolidone based gels with non-syneresing adhesive characteristics. In one embodiment the gels contain an ionic drug which can be iontophoretically delivered. Tacifiers such as poly-2-acrylamido-2-methylpropane sulfonic acid may be added to the formulation at levels of 2%-20%.
Hydrogel materials based on polymerized 2-acrylamido-2-methylpropane sulfonate salts are known as electrode materials from U.S. Pat. Nos. 4,391,278 and 4,768,523. In U.S. Pat. No. 4,391,278 a tape electrode is disclosed which includes a gel comprising polymerized 2-acrylamido-2-methane sulfonic acid or a salt thereof, water and/or an alcohol to give electrically conductive, flexible skin adhering properties. All of the example formulations employing an alcohol utilize glycerol although propylene glycol and sorbitol are also mentioned as useful.