An ultrasound diagnosis apparatus has been used for tests and diagnosis for various body tissues such as the heart, liver, kidney, and mammary gland. Recently, an ultrasonic contrast agent (hereinafter, “contrast agent”) of an intravenous administration type has been commercially introduced, and the contrast echo method has been used. With the contrast echo method, minute bubbles (hereinafter, “microbubbles”) or the like are intravenously administered as a contrast agent to enhance the blood-flow signals, realizing clear observation of the blood flowing state.
Furthermore, research has been conducted on application of ultrasound to medical treatment. Through such research, it has been confirmed that, when emitting ultrasound waves onto the subject, pores are temporarily formed in cells by mechanical action of cavitation, and that they make genes and medicinal substances easy to permeate into the cells. It has also been confirmed that, when microbubbles are injected, pores are temporarily formed in cells by mechanical action of cavitation of the microbubbles even if the ultrasonic sound pressure is low, and that they enhance the permeation of genes and medicinal substances into the cells. The phenomenon that ultrasonic irradiation improves the permeation of genes or medical substances into the cells is sometimes called as “sonopolation”.
The problem to be solved by the present invention is to present an ultrasound apparatus that can enhance the penetration of genes and medicinal substances into a specific site by use of microbubbles, and a controlling method and a non-transitory computer readable medium for such an ultrasound apparatus.