This invention concerns certain derivatives of fluorenes that are useful as antiarrhythmic agents.
U.S. Pat. Nos. 4,197,313 and 4,277,495 describe various 9-aminoalkylfluorene derivatives that are useful as antiarrhythmic agents. All of the disclosed compounds are primary, secondary or tertiary amines, or acid addition salts thereof. It has long been known that many antiarrhythmic agents also have local anesthetic activity, and that the cardiac activity of such compounds may in some way be associated with the local anesthetic properties. It has been thought that in order to have anesthetic and/or antiarrhythmic activity, an amino compound had to be basic, ie. a primary, secondary or tertiary amine. Accordingly, no non-basic aminoalkyl fluorene antiarrhythmic agents have heretofore been known.
An object of this invention is to provide a group of non-basic N-alkanoyl-aminoalkylfluorenes that are active as antiarrhythmic agents.