1. Field of the Invention
This invention relates to imidazo[4,5-c]quinoline amine compounds. In another aspect this invention relates to immunomodulator compounds. In other aspects this invention relates to pharmaceutical compositions containing such compounds, and pharmacological methods of using such compounds.
2. Description of the Related Art
Certain 1H-imidazo[4,5-c]quinolin-4-amines are known as antiviral agents and/or as immunomodulators. Such compounds are disclosed e.g., in U.S. Pat. Nos. 4,689,338, 4,929,624, 5,037,986, 5,266,575, 5,268,376, 5,346,905, European Patent Application No. 0,385,630 A2 and WO92/15582 (all to Gerster et al.). Commonly assigned copending application 08/092,002 (Lindstrom et al.) filed Jul. 15, 1993, now abandoned, discloses immunomodulator imidazopyridine amines of the formula ##STR1##
R.sub.1 is selected from the group consisting of hydrogen; CHR.sub.x R.sub.y wherein R.sub.x is hydrogen and R.sub.y is selected from the group consisting of straight chain, branched chain, or cyclic alkyl containing one to about ten carbon atoms, straight chain or branched chain alkenyl containing two to about ten carbon atoms, straight chain or branched chain hydroxyalkyl containing one to about six carbon atoms, alkoxyalkyl wherein the alkoxy moiety contains one to about four carbon atoms and the alkyl moiety contains one to about six carbon atoms, and phenylethyl; and --CH.dbd.CR.sub.z R.sub.z wherein each R.sub.z is independently straight chain, branched chain, or cyclic alkyl of one to about six carbon atoms.
U.S. Pat. No. 5,352,784 (Nickolaides et al.) discloses immunomodulator 6,7-fused cycloalkylimidazopyridine amines.