WO 2007/131201 and WO 2008/154259 disclose compounds with activity as hedgehog signalling pathway modulators, including 2-Methyl-4′-trifluoromethoxy-biphenyl-3-carboxylic acid [6-(cis-2,6-dimethyl-morpholin-4-yl)-pyridin-3-yl]-amide. Topical pharmaceutical compositions are not specifically disclosed. The disclosures of the publications cited in this specification are herein incorporated by reference in their entirety.