This invention relates to crystalline salt forms of the cephalosporin antibiotic ceftazidime. In particular, it relates to the crystalline dihydrobromide salt of ceftazidime and to crystalline dihydrobromide monohydrates.
The antibiotic ceftazidime is disclosed in U.S. Pat. No. 4,258,041, Mar. 24, 1981, and has the chemical name (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(2-carboxyprop-2-oxyimino)acetami do]-3-(1-pyridiniummethyl)-3-cephem-4-carboxylate. Ceftazidime is a potent broad spectrum semi-synthetic antibiotic which can be formulated as the crystalline pentahydrate. Ceftazidime pentahydrate has been prepared with ceftazidime bishydrochloride salt as discussed in U.S. Pat. No. 4,329,453, May 11, 1982.
A crystallline ceftazidime bishydrochloride salt form is disclosed in U.K. Pat. No. 2064513.