This invention generally pertains to heterocyclic carbon compounds having drug and bio-affecting properties and to their preparation and use. In particular, the invention is concerned with various heterocyclic derivatives characterized by Formulas I and II, infra., which are inhibitors of blood platelet aggregation.
United States patents relating to the carboxylic acid and ester derivatives of the various heterocycles disclosed herein are as follows:
Thiazole compounds in Field of Search 514/365 and 548/203, 204.
Cavalla, et al., U.S. Pat. No. 3,506,679 discloses 2,5- and 4,5-diarylthiazolyl lower fatty acids having anti-inflammatory activity of formula (1) wherein R.sup.3 is a straight chain or branched aliphatic acid radical containing 2-6 carbon atoms. ##STR2##
Hepworth, et al., U.S. Pat. No. 3,538,107 discloses aryl-thiazolyl-acetic acid derivatives having anti-inflammatory, analgesic and antipyretic properties of formula (2) such as alpha-[2-(4-chlorophenyl) thiazol-4-yl]propionic acid. ##STR3##
Hepworth, et al., U.S. Pat. No. 3,661,920 discloses thiazole derivatives having anti-inflammatory, analgesis and antipyretic activity of formula (3). ##STR4##
Malen, et al., U.S. Pat. No. 3,821,237 discloses thiazolyl benzoic acid compounds having fibrinolytic, platelet stickiness decreasing and antiulcer properties of formula (4). ##STR5##
Malen, et al., U.S. Pat. No. 3,840,548 discloses thiazolylbenzoic acid compounds having thrombolytic properties of formula (5). ##STR6##
Rynbrandt, et al., U.S. Pat. No. 4,168,315 discloses dianisyl thiazole compounds having reduced platelet adhesiveness and inhibition of platelet aggregation properties of formula (6). ##STR7##
Yoshino, et al., U.S. Pat. No. 4,659,726 discloses 4,5-bis(4-methoxyphenyl)-2-(pyrrol-2-yl)thiazoles having platelet aggregation inhibiting properties of formula (7). ##STR8##
Lutomski, et al., U.S. Pat. No. 4,791,124 discloses oxazole and thiazole compounds having insecticidal properties of formula (8). ##STR9##