1. Field of the Invention
This invention relates generally to the field of pharmaceutical chemistry and medical science and, more specifically, to a new antiviral water-soluble pharmacological product with anti-HIV effect, based on ionic silver and methylene blue compound, as well as its production method, and includes the examples of HIV-infected patient's treatment.
2. Description of the Prior Art
Far back in the past, there used to be a medicine based on the compound of methylene blue in nitrate form and silver nitrate; it was manufactured in Germany by Merck under the Argochrom trade name from 1916 to 1945 and was imported to a number of countries. The composition of Argochrom corresponds to the Patent of Austria No. 69476 (branded equivalent) valid since 1914; the name of the substance in German was “Silber methylene blau” until 1920.
Argochrom powder was distinguished by increased toxicity and flammability due to a high content of nitrate in molecule structure. This medicine was intended for treating bacterial infections such as gonorrhea, while its antiviral effect was unknown at that time.
According to the Claim of Patent of Austria No. 69476 for the Production Method, the silver and dye compound was produced in two stages, while we have developed a one-stage synthesis procedure for the new composition complex, namely by using an organic silver compound instead of highly water-soluble silver salt, such as silver nitrate which was used for the production of the Argochrom medicine.
Also, there is the Patent of Russia No. 2390343, date of priority Dec. 15, 2008 (prototype) titled “Water-soluble substance with antiviral and immunomodulatory effect, based on the ionic silver and methylene blue compound, as well as its production method.”
Since silver chloride is water-insoluble, the method of target product synthesis described in this patent involved the use of aqueous ammonia in large amounts to produce a transient soluble unstable complex with ammonia, which makes the process environmentally harmful and may lead to explosion hazards in case of technology violations.
The advantage of the ammonia-based technology was no loss of silver (50% of the metal was in the form of silver chloride and thus, no need to compensate for such losses using the complicated technology of silver regeneration).
Compared to Argochrom being a branded equivalent of Argothiazin-A claimed herein, the dry product obtained according to the above mentioned Patent of Russia was not flammable.
It is common knowledge that ions of silver are active killers of various pathogenic bacteria and viruses.
Methylene blue is a phenothiazine dye. Dyes of this type are able to penetrate into the structure of nucleic acids of viruses and block virus reproduction inside the host cell by tight binding with nucleoside bases of viruses containing both DNA and RNA.