Advancements in the delivery of therapeutic agents is an ongoing endeavor. Polymeric carriers have been developed for the delivery of therapeutic agents with the goal of effective administration to treat diseases and conditions treatable by the therapeutic agents.
Many conventional polymeric carriers suffer from disadvantages associated with solubility and stability in the circulatory system as well as relative low therapeutic agent capacity. Further disadvantages of conventional polymeric carriers include uncontrollable release, including premature release, of their therapeutic agent cargo.
A need exists for improved polymeric carriers of therapeutic agents that are stable and soluble under physiological conditions such as the circulatory system, that offer high therapeutic agent densities, and that provide controllable release of their therapeutic agent cargo. The present invention seeks to fulfill these needs and provides further related advantages.