Cosmological constant problem
In cosmology, the cosmological constant problem or vacuum catastrophe is the substantial disagreement between the observed values of vacuum energy density (the small value of the cosmological constant) and the much larger theoretical value of zero-point energy suggested by quantum field theory. Depending on the Planck energy cutoff and other factors, the quantum vacuum energy contribution to the effective cosmological constant is calculated to be between 50 and as much as 120 orders of magnitude greater than observed, a state of affairs described by physicists as "the largest discrepancy between theory and experiment in all of science" and "the worst theoretical prediction in the history of physics".