Cannabinoid
Cannabidiol
#### Cannabidiol

Cannabidiol (CBD) is mildly [psychotropic](/wiki/Psychotropic "Psychotropic"). Evidence shows that the compound counteracts cognitive impairment associated with the use of cannabis. Cannabidiol has little affinity for [CB1](/wiki/Cannabinoid_receptor%23CB1 "Cannabinoid receptor#CB1") and [CB2](/wiki/Cannabinoid_receptor%23CB2 "Cannabinoid receptor#CB2") receptors but acts as an indirect antagonist of cannabinoid agonists. It was found to be an antagonist at the putative new cannabinoid receptor, [GPR55](/wiki/GPR55 "GPR55"), a [GPCR](/wiki/GPCR "GPCR") expressed in the [caudate nucleus](/wiki/Caudate_nucleus "Caudate nucleus") and [putamen](/wiki/Putamen "Putamen"). Cannabidiol has also been shown to act as a [5\-HT1A receptor](/wiki/5-HT1A_receptor "5-HT1A receptor") agonist. CBD can interfere with the uptake of [adenosine](/wiki/Adenosine "Adenosine"), which plays an important role in biochemical processes, such as energy transfer. It may play a role in promoting sleep and suppressing arousal.

CBD shares a [precursor](/wiki/wikt:Precursor "Precursor") with THC and is the main cannabinoid in CBD\-dominant *Cannabis* strains. CBD has been shown to play a role in preventing [the short\-term memory loss associated with THC](/wiki/Cannabis_and_memory "Cannabis and memory").

There is tentative evidence that CBD has an anti\-psychotic effect, but research in this area is limited.


What is the role of GPR55 in relation to cannabidiol?