RTL6
Protein
Protein
-------

### Primary information

The primary [amino acid](/wiki/Amino_acid "Amino acid") sequence for RTL6 is made up of 239 residues. There are no known [alternative splice](/wiki/Alternative_splicing "Alternative splicing") variants of the protein. The [molecular weight](/wiki/Molecular_mass "Molecular mass") of the protein is 26\.2 kDa and the [isoelectric point](/wiki/Isoelectric_point "Isoelectric point") is 11\.58\.Brendel, V., Bucher, P., Nourbakhsh, I.R., Blaisdell, B.E. \& Karlin, S. (1992\) "Methods and algorithms for statistical analysis of protein sequences" Proc. Natl. Acad. Sci. U.S.A. 89, 2002\-2006\. RTL6 is a [proline](/wiki/Proline "Proline") and [arginine](/wiki/Arginine "Arginine") rich protein.[thumb\|I\-TASSER predicted secondary and tertiary structures for the RTL6 protein.J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I\-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7\-8, 2015\.A Roy, A Kucukural, Y Zhang. I\-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725\-738, 2010\.Y Zhang. I\-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008\.[thumb\|Immunohistochemical staining of human stomach shows strong nuclear and cytoplasmic positivity in glandular cells.](/wiki/File:LDOC1L_Stain.png "LDOC1L Stain.png")](/wiki/File:LDOC1L.jpg "LDOC1L.jpg")

### Domains and motifs

RTL6 contains a predicted leucine zipper motif known to participate in nucleic acid binding in other proteins. RTL6 also contains a domain of unknown function from amino acid residues 98\-177 . RTL6 is one of a number of genes belonging to the DUF4939 (domain of unknown function) [superfamily](/wiki/Protein_superfamily "Protein superfamily").

### Secondary structure

The [secondary structure](/wiki/Biomolecular_structure "Biomolecular structure") of RTL6 is made up of largely [alpha helices](/wiki/Alpha_helix "Alpha helix").Garnier, Gibrat, and Robson, Meth. Enzymol., R.F. Doolittle ed. (1996\) 266:97\-120 One region of RTL6 is also predicted to participate in a [coiled\-coil](/wiki/Coiled_coil "Coiled coil") structure from amino acid residues 29–63\.

### Post\-translational modifications

There are also two predicted [phosphorylation](/wiki/Phosphorylation "Phosphorylation") sites for [Protein Kinase C](/wiki/Protein_kinase_C "Protein kinase C") with high confidence scores at amino acid residues 6 and 45\. There is also a predicted [ubiquitination](/wiki/Ubiquitin "Ubiquitin") site with medium\-confidence at amino acid residue 8\.
[left\|thumb\|An annotated schematic of the RTL6 protein showing motifs and predicted phosphorylation and ubiquitination sites.](/wiki/File:LDOC1L_Protein_Annotation.png "LDOC1L Protein Annotation.png")

### Cellular sublocation

RTL6 is expected to be localized to the nucleus and cytosol based on the presence of a leucine zipper domain, the absence of signals indicating [secretion](/wiki/Secretion "Secretion") or transmembrane domains, and immunohistochemical staining.


What might be some potential consequences of having a high concentration of proline and arginine in a protein?