Valbenazine
Pharmacokinetics
### Pharmacokinetics

Valbenazine is a [prodrug](/wiki/Prodrug "Prodrug") which is an [ester](/wiki/Ester "Ester") of \[\+]\-α\-[dihydrotetrabenazine](/wiki/Dihydrotetrabenazine "Dihydrotetrabenazine") (DTBZ) with the amino acid L\-[valine](/wiki/Valine "Valine"). It is extensively [hydrolyzed](/wiki/Hydrolyzed "Hydrolyzed") to the [active metabolite](/wiki/Active_metabolite "Active metabolite") DTBZ. [Plasma protein binding](/wiki/Plasma_protein_binding "Plasma protein binding") of valbenazine is over 99%, and that of DTBZ is about 64%. The [biological half\-life](/wiki/Biological_half-life "Biological half-life") of both valbenazine and DTBZ is 15 to 22 hours. Liver enzymes involved in inactivation are CYP3A4, [CYP3A5](/wiki/CYP3A5 "CYP3A5") and CYP2D6\. The drug is excreted, mostly in form of inactive metabolites, via the urine (60%) and the [feces](/wiki/Feces "Feces") (30%).Valbenazine .


Can valbenazine be used to treat any specific medical condition?