what is the role of acetylcholinesterase in the neuromuscular junction
Acetylcholinesterase Acetylcholinesterase (HGNC symbol ACHE; EC 3.1.1.7), also known as AChE or acetylhydrolase, is the primary cholinesterase in the body. It is an enzyme that catalyzes the breakdown of acetylcholine and of some other choline esters that function as neurotransmitters. AChE is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate synaptic transmission. It belongs to carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides.
Na+/K+-ATPase Na+/K+-ATPase (sodium-potassium adenosine triphosphatase, also known as the Na+/K+ pump or sodiumâ€“potassium pump) is an enzyme (EC 3.6.3.9) (an electrogenic transmembrane ATPase) found in the plasma membrane of all animal cells. The Na+/K+-ATPase enzyme is a solute pump that pumps sodium out of cells while pumping potassium into cells, both against their concentration gradients. This pumping is active (i.e. it uses energy from ATP) and is important for cell physiology. An example application is nerve conduction.