beri beri is caused by lack of vitamin
Thiamine deficiency Thiamine deficiency, also known as beriberi, is a condition that occurs due to not enough thiamine (vitamin B1).[1] There are two main types: wet beriberi, and dry beriberi.[1] Wet beriberi results in a fast heart rate, shortness of breath, and leg swelling.[1] Dry beriberi results in numbness of the hands and feet, confusion, trouble moving the legs, and pain.[1] A form with loss of appetite and constipation may also occur.[3]
Vitamin C Vitamin C megadosage is a term describing the consumption or injection of vitamin C in doses comparable to or higher than the amounts produced by the livers of mammals which are able to synthesize vitamin C. The theory behind this, although not the actual term, was described in 1970 in an article by Linus Pauling, a famous scientist who had been awarded the Nobel Prize in Chemistry in 1954. Briefly, his position was that for optimal health, humans should be consuming at least 2,300 mg/day to compensate for the inability to synthesize vitamin C. The recommendation also fell into the consumption range for gorillas - a non-synthesizing near-relative to humans.[177] A second argument for high intake is that serum ascorbic acid concentrations increase as intake increases until it plateaus at about 190 to 200 micromoles per liter (µmol/L) once consumption exceeds 1,250 milligrams.[178] As noted, government recommendations are a range of 40 to 110 mg/day and normal plasma is approximately 50 µmol/L, so 'normal' is about 25% of what can be achieved when oral consumption is in the proposed megadose range.