when did the flu shot first come out
Influenza vaccine Vaccination against influenza began in the 1930s with large scale availability in the United States beginning in 1945.[12][13] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[14] The wholesale price in the developing world is about $5.25 USD per dose as of 2014.[15] In the United States, it costs less than $25 USD as of 2015.[16]
Smallpox vaccine Smallpox vaccine, the first successful vaccine to be developed, was introduced by Edward Jenner in 1796. He followed up his observation that milkmaids who had previously caught cowpox did not later catch smallpox by showing that inoculated cowpox protected against inoculated smallpox. The word "vaccine" is derived from Variolae vaccinae (i.e. smallpox of the cow), the term devised by Jenner to denote cowpox and used in the long title of his An enquiry into the causes and effects of Variolae vaccinae, known by the name of cow pox.[2] Vaccination, the term which soon replaced cowpox inoculation and vaccine inoculation, was first used in print by Jenner's friend, Richard Dunning in 1800.[3] Initially, the terms vaccine/vaccination referred only to smallpox, but in 1881 Louis Pasteur proposed that to honour Jenner the terms be widened to cover the new protective inoculations being introduced.