when did paracetamol become available in the uk
Paracetamol Paracetamol was first marketed in the United States in 1950 under the name Triagesic, a combination of paracetamol, aspirin, and caffeine.[123] Reports in 1951 of three users stricken with the blood disease agranulocytosis led to its removal from the marketplace, and it took several years until it became clear that the disease was unconnected.[123] Paracetamol was marketed in 1953 by Sterling-Winthrop Co. as Panadol, available only by prescription, and promoted as preferable to aspirin since it was safe for children and people with ulcers.[123][125][133] In 1955, paracetamol was marketed as Children's Tylenol Elixir by McNeil Laboratories.[134] In 1956, 500Â mg tablets of paracetamol went on sale in the United Kingdom under the trade name Panadol, produced by Frederick Stearns & Co, a subsidiary of Sterling Drug Inc. In 1963, paracetamol was added to the British Pharmacopoeia, and has gained popularity since then as an analgesic agent with few side-effects and little interaction with other pharmaceutical agents.[123] Concerns about paracetamol's safety delayed its widespread acceptance until the 1970s, but in the 1980s paracetamol sales exceeded those of aspirin in many countries, including the United Kingdom. This was accompanied by the commercial demise of phenacetin, blamed as the cause of analgesic nephropathy and hematological toxicity.[109] In 1988 Sterling Winthrop was acquired by Eastman Kodak which sold the over the counter drug rights to SmithKline Beecham in 1994.[135]
Doritos Doritos are sold in many countries worldwide in assorted flavors. They launched nationally in the United States in 1966,[5] with only one flavor: toasted corn.[19] The product proved successful, but additional market research revealed that many consumers outside the Southwest and West considered the chip to be too bland and not spicy enough for what was perceived as a Mexican snack. Frito-Lay therefore developed taco-flavored Doritos, which also became successful after they were introduced nationally in 1967.[19] National distribution of nacho cheese-flavored Doritos began in 1972, and were also a hit.[19] For a short run in the late 1970s, Sour Cream and Onion flavored Doritos were available, but were discontinued in the early 1980s. A Sesame seed flavored chip was also available for a short time in the late 1970s.[20] In 1986, Cool Ranch Doritos made their debut and also became popular.[19] Cool Ranch Doritos are sold under the name "Cool Original" in the UK and are called "Cool American" elsewhere in Europe, as ranch dressing is less common in those places.