grey's anatomy when does izzie get cancer
Izzie Stevens Heigl garnered critical acclaim for her performance as Izzie and received numerous awards and nominations for her role, winning the "Outstanding Supporting Actress In A Drama Series" at the 2007 Emmy Awards. She was critical of the character's development during the show's fourth season, particularly her romance with George. She declined to put herself forward for the 2008 Emmy Awards, citing insufficient material in the role. After speculation that Izzie would be killed off in the fifth season, the character was diagnosed with Stage 4 metastatic melanoma. She married Alex in the series' one-hundredth episode, and afterwards, her tumor was successfully removed. Izzie made her final appearance in the sixth season, leaving Seattle after Alex refused to resume their marriage. Heigl requested to be released from her contract 18Â months early, in order to spend more time with her family. In January 2012, Heigl reported that she would like to return to Grey's Anatomy to give closure to her character, however, Rhimes confirmed that there were no plans to have the character return at that time and has since stated that she has no plans to ever re-approach Izzie's storyline again.
Lexie Grey Although initially happy in her relationship with Jackson, Lexie is distraught when she learns that Mark has begun a relationship with a woman named Julia. At a charity softball match, her jealousy gets the better of her, resulting in her throwing a ball at Julia. Sensing that Lexie is still in love with Mark, Jackson calls off their relationship. Lexie begins working with Derek's service and becomes increasingly proficient in neurosurgery, helping Derek with a set of "hopeless cases" - high risk surgeries for patients who had otherwise run out of options. During a surgery, Derek is called away on an emergency, leaving Lexie and Meredith to carry out the procedure on their own. Though Derek had instructed them to merely reduce the patient's brain tumour, Meredith allows Lexie to remove it completely, despite not being authorized by either the patient or Derek to due so. The sisters celebrate the successful surgery, but when the patient wakes up, Lexie is devastated to discover that the patient suffered severe brain damage, losing the ability to speak. Alex, Jackson and April Kepner (Sarah Drew) move out of Meredith's house without inviting Lexie to join them, and with Derek and Meredith settling down with baby Zola, Lexie begins to feel increasingly lonely and isolated. After being left babysitting Zola on Valentine's Day, she decides to try to salvage her relationship with Mark. However, after plucking up the courage to visit his apartment, she finds Mark studying with Jackson and loses her nerve, instead claiming that she was visiting to set up a play date for Zola and Sofia. When Mark confides in Derek that he and Julia have been discussing having a baby, Derek warns Lexie not to miss her chance again, resulting in her professing her love to a shell-shocked Mark, who merely thanks her for her candour. He later confesses to Derek that he feels the same way, but is unsure about how to go about things. Days later, Lexie is named as part of a team of surgeons that will be sent to Boise to separate conjoined twins, along with Mark, Meredith, Derek, Cristina and Arizona Robbins (Jessica Capshaw); however, while flying to their destination, the doctors' plane crashes in the wilderness. Lexie is crushed under debris from the plane, but manages to alert Mark and Cristina to help her. The pair try in vain to free Lexie, who realises that she is suffering from a hemothorax and is unlikely to survive. While Cristina tries to find an oxygen tank and water for to try and save Lexie, Mark takes Lexie by the hand and professes his love for her, telling her that they were "meant to be". While fantasizing about the future that she and Mark could have had together, Lexie succumbs to her injuries, and dies moments before Meredith arrives. The remaining doctors are left in the woods waiting for rescue, with Mark refusing to let go of Lexie's hand.