what is the major constituent of a chromosome
Centromere The centromere is the specialized DNA sequence of a chromosome that links a pair of sister chromatids (a dyad).[1] During mitosis, spindle fibers attach to the centromere via the kinetochore.[2] Centromeres were first thought to be genetic loci that direct the behavior of chromosomes.
Kinetochore The kinetochore (/kɪˈnɛtəkɔər/, /-ˈniːtəkɔər/) is a protein structure on chromatids where the spindle fibers attach during cell division to pull sister chromatids apart.[1] Their proteins help to hold the sister chromatids together and also play a role in chromosome editing.[2]