what is the major advantage of blast over smith-waterman
BLAST The main idea of BLAST is that there are often High-scoring Segment Pairs (HSP) contained in a statistically significant alignment. BLAST searches for high scoring sequence alignments between the query sequence and the existing sequences in the database using a heuristic approach that approximates the Smith-Waterman algorithm. However, the exhaustive Smith-Waterman approach is too slow for searching large genomic databases such as GenBank. Therefore, the BLAST algorithm uses a heuristic approach that is less accurate than the Smith-Waterman algorithm but over 50 times faster. [8] The speed and relatively good accuracy of BLAST are among the key technical innovations of the BLAST programs.
The Rifleman The program was titled to reflect McCain's use of a Winchester rifle, customized to allow repeated firing by cycling its lever action. He demonstrated this technique in the opening credits of every episode, as well as a second modification that allowed him to cycle the action with one hand.