the maximum window of time a fibrinolytic can be administered​ is
Reperfusion therapy Thrombolytic therapy is indicated for the treatment of STEMI – if it can begin within 12 hours of the onset of symptoms, and the person is eligible based on exclusion criteria, and a coronary angioplasty is not immediately available.[4] Thrombolysis is most effective in the first 2 hours. After 12 hours, the risk of intracranial bleeding associated with thrombolytic therapy outweighs any benefit.[2][5][6] Because irreversible injury occurs within 2–4 hours of the infarction, there is a limited window of time available for reperfusion to work.
Midazolam Midazolam, marketed under the trade name Versed, among others, is a medication used for anesthesia, procedural sedation, trouble sleeping, and severe agitation.[3] It works by inducing sleepiness, decreasing anxiety, and causing a loss of ability to create new memories.[3] It is also useful for the treatment of seizures.[5] Midazolam can be given by mouth, intravenously, or injection into a muscle, by spraying into the nose, or through the cheek.[3][5] When given intravenously, it typically begins working within five minutes; when injected into a muscle, it can take fifteen minutes to begin working.[3] Effects last for between one and six hours.[3]