the leaving group in the fischer esterification is
Fischer–Speier esterification Acid anhydrides are more reactive than esters because the leaving group is a carboxylate anionâ€”a better leaving group than an alkoxide anion because their negative charge is more delocalised. However, such routes generally result in poor atom economy. For example, in reacting ethanol with acetic anhydride, ethyl acetate forms and acetic acid is kicked out as a leaving group, which is considerably less reactive than an acid anhydride and will be left as a byproduct (in a wasteful 1:1 ratio with the ester product) if product is collected immediately. If conditions are acidic enough, the acetic acid can be further reacted via the Fischer esterification pathway, but at a much slower pace. However, in many carefully designed syntheses, reagents can be designed such that acid anhydrides are generated in situ and carboxylic acid byproducts are reactivated, and Fischer esterification routes are not necessarily mutually exclusive with acetic anhydride routes. (Examples of this include the common undergraduate organic lab experiment involving the acetylation of salicylic acid to yield aspirin.)
Barium acetate Barium acetate (Ba(C2H3O2)2) is the salt of barium(II) and acetic acid.