what is the role of the a-site in translation
Translation (biology) The ribosome has three sites for tRNA to bind. They are the aminoacyl site (abbreviated A), the peptidyl site (abbreviated P) and the exit site (abbreviated E). With respect to the mRNA, the three sites are oriented 5’ to 3’ E-P-A, because ribosomes move toward the 3' end of mRNA. The A-site binds the incoming tRNA with the complementary codon on the mRNA. The P-site holds the tRNA with the growing polypeptide chain. The E-site holds the tRNA without its amino acid. When an aminoacyl-tRNA initially binds to its corresponding codon on the mRNA, it is in the A site. Then, a peptide bond forms between the amino acid of the tRNA in the A site and the amino acid of the charged tRNA in the P site. The growing polypeptide chain is transferred to the tRNA in the A site. Translocation occurs, moving the tRNA in the P site, now without an amino acid, to the E site; the tRNA that was in the A site, now charged with the polypeptide chain, is moved to the P site. The tRNA in the E site leaves and another aminoacyl-tRNA enters the A site to repeat the process.[6]
Bible translations In 1999, Wycliffe Bible Translators announced Vision 2025â€”a project that intends to commence Bible translation in every remaining language community by 2025. As of 1 October 2015 they estimate that around 165 - 180 million people, speak those 1,800 languages where translation work still needs to begin. Wycliffe also stated that parts of the Bible are available in approximately 2,900 out of the 6,877 known languages, and that there are currently 554 languages with a complete Bible translation. The New Testament is available in 1,333 languages and many more have at least one book of the Bible available.[20]