what are common early manifestations of parkinson's disease
Parkinson's disease Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.[1] The symptoms generally come on slowly over time.[1] Early in the disease, the most obvious are shaking, rigidity, slowness of movement, and difficulty with walking.[1] Thinking and behavioral problems may also occur.[2] Dementia becomes common in the advanced stages of the disease.[2] Depression and anxiety are also common occurring in more than a third of people with PD.[2] Other symptoms include sensory, sleep, and emotional problems.[1][2] The main motor symptoms are collectively called "parkinsonism", or a "parkinsonian syndrome".[4][8]
Prion In humans, prions have been hypothesized as the cause of Creutzfeldt–Jakob disease (CJD) and its variant (vCJD), Gerstmann–Sträussler–Scheinker syndrome, “fatal familial insomnia”, and kuru.[2] All known prion diseases in mammals affect the structure of the brain or other neural tissue; all are progressive, have no known effective treatment, and are always fatal.[6] Multiple system atrophy (MSA), a rare human neurodegenerative disease, features a misfolded version of a protein called alpha-synuclein, and is therefore also classifiable as a prion disease.[7] Several yeast proteins have also been identified as having prionogenic properties.[8][9]