addison disease is caused by hyposecretion of hormones from the
Addison's disease Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones.[1] Symptoms generally come on slowly and may include abdominal pain, weakness, and weight loss.[1] Darkening of the skin in certain areas may also occur.[1] Under certain circumstances, an adrenal crisis may occur with low blood pressure, vomiting, lower back pain, and loss of consciousness.[1] An adrenal crisis can be triggered by stress, such as from an injury, surgery, or infection.[1]
Pancreas The pancreas is a secretory structure with an internal hormonal role (endocrine) and an external digestive role (exocrine). The endocrine part is composed of hormonal tissue distributed along the pancreas in discrete units called islets of Langerhans.[2] Islets of Langerhans have a well-established structure and form density routes through the exocrine tissue.[2] The exocrine part has two main ducts, the main pancreatic duct, and the accessory pancreatic duct. These drain enzymes through the ampulla of Vater into the duodenum.[7]