what is the role of the a-site in translation
Translation (biology) The ribosome has three sites for tRNA to bind. They are the aminoacyl site (abbreviated A), the peptidyl site (abbreviated P) and the exit site (abbreviated E). With respect to the mRNA, the three sites are oriented 5’ to 3’ E-P-A, because ribosomes move toward the 3' end of mRNA. The A-site binds the incoming tRNA with the complementary codon on the mRNA. The P-site holds the tRNA with the growing polypeptide chain. The E-site holds the tRNA without its amino acid. When an aminoacyl-tRNA initially binds to its corresponding codon on the mRNA, it is in the A site. Then, a peptide bond forms between the amino acid of the tRNA in the A site and the amino acid of the charged tRNA in the P site. The growing polypeptide chain is transferred to the tRNA in the A site. Translocation occurs, moving the tRNA in the P site, now without an amino acid, to the E site; the tRNA that was in the A site, now charged with the polypeptide chain, is moved to the P site. The tRNA in the E site leaves and another aminoacyl-tRNA enters the A site to repeat the process.[6]
New International Version The NIV began in 1956 with the formation of a small committee to study the value of producing a translation in the common language of the American people.[6] The project was formally started after a meeting in 1965 at Trinity Christian College in Palos Heights, Illinois, of the Christian Reformed Church, National Association of Evangelicals, and a group of international scholars. The initial "Committee on Bible Translation" consisted of E. Leslie Carlson, Edmund Clowney, Ralph Earle, Jr., Burton L. Goddard, R. Laird Harris, Earl S. Kalland, Kenneth Kantzer, Robert H. Mounce, Charles F. Pfeiffer, Charles Caldwell Ryrie, Francis R. Steele, John H. Stek, J. C. Wenger, Stephen W. Paine, and Marten Woudstra. The New York Bible Society (now Biblica) was selected to do the translation. The New Testament was released in 1973 and the full Bible in 1978.