addison disease is caused by hyposecretion of hormones from the
Addison's disease Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones.[1] Symptoms generally come on slowly and may include abdominal pain, weakness, and weight loss.[1] Darkening of the skin in certain areas may also occur.[1] Under certain circumstances, an adrenal crisis may occur with low blood pressure, vomiting, lower back pain, and loss of consciousness.[1] An adrenal crisis can be triggered by stress, such as from an injury, surgery, or infection.[1]
Epinephrine Epinephrine, also known as adrenalin or adrenaline, is a hormone, neurotransmitter, and medication.[3][4] Epinephrine is normally produced by both the adrenal glands and certain neurons.[3] It plays an important role in the fight-or-flight response by increasing blood flow to muscles, output of the heart, pupil dilation, and blood sugar.[5][6] It does this by binding to alpha and beta receptors.[6] It is found in many animals and some single cell organisms.[7][8] Napoleon Cybulski first isolated epinephrine in 1895.[9]