the only depolarizing muscle relaxant in clinical use is
Neuromuscular-blocking drug The prototypical depolarizing blocking drug is succinylcholine (suxamethonium). It is the only such drug used clinically. It has a rapid onset (30 seconds) but very short duration of action (5â€“10 minutes) because of hydrolysis by various cholinesterases (such as butyrylcholinesterase in the blood). Succinylcholine was originally known as diacetylcholine because structurally it is composed of two acetylcholine molecules joined with a methyl group. Decamethonium is sometimes, but rarely, used in clinical practice.
Muscles of respiration The muscles of respiration are those muscles that contribute to inhalation and exhalation, by aiding in the expansion and contraction of the thoracic cavity. The diaphragm and, to a lesser extent, the intercostal muscles drive respiration during quiet breathing. Additional 'accessory muscles of respiration' are typically only used under conditions of high metabolic demand (e.g. exercise) or respiratory dysfunction (e.g. an asthma attack). However, in instances where these accessory muscles become stiff and hard, expansion of the rib cage can be restricted. Maintenance of the elasticity of these muscles is crucial to the health of the respiratory system and to maximize its functional capabilities.