when was the first gender reassignment surgery performed
Sex reassignment surgery (male-to-female) Lili Elbe was the first known recipient of male-to-female sex reassignment surgery, in Germany in 1930. She was the subject of five surgeries: one of penectomy and orchiectomy, one intended to transplant ovaries, two to remove the ovaries after transplant rejection, and vaginoplasty. However, she died three months after her fifth operation.
Sexual differentiation in humans The development of sexual differences begins with the XY sex-determination system that is present in humans, and complex mechanisms are responsible for the development of the phenotypic differences between male and female humans from an undifferentiated zygote.[3] Females have two X chromosomes, and males have a Y chromosome and an X chromosome. At an early stage in embryonic development, both sexes possess equivalent internal structures. These are the mesonephric ducts and paramesonephric ducts. The presence of the SRY gene on the Y chromosome causes the development of the testes in males, and the subsequent release of hormones which cause the paramesonephric ducts to regress. In females, the mesonephric ducts regress.