Met-증식 재발은 리간드 간세포 성장인자뿐만 아니라 수용체를 과도하게 표현했으며 MAPK 경로 활성화에 필요한 MET 키나제 억제제에 매우 민감했다.
The Met-amplified recurrences overexpressed the receptor as well as its ligand hepatocyte growth factor, and were exquisitely sensitive to MET kinase inhibitors, which was required for activation of the MAPK pathway.