몇몇 사례 보고서에서, MCTD는 비호지킨 림프종 및 흉선과 같은 악성 종양과 관련이 있었으며, MCTD와 암 위험 증가 사이의 가능한 연관성이 이전 연구에서도 제시되었다.
In several case reports, MCTD was associated with malignancies such as non-Hodgkin's lymphoma and thymoma, possible association between MCTD and the increased risk of cancer was also suggested in previous studies.