微小病变型肾病综合征可能与细胞免疫紊乱，特别是T细胞免疫功能紊乱有关，其依据在于：①MCN肾组织中无免疫球蛋白及补体沉积；②T细胞数降低，CD4/CD8比例失衡，Ts活性增高，淋巴细胞转化率降低，PHA皮试反应降低；③抑制T细胞的病毒感染可诱导本病缓解；④出现T细胞功能异常的疾病如霍奇金病可导致MCN；⑤抑制T细胞的皮质激素及免疫抑制剂可诱导本病缓解。
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