【发病率】自1952年Bruton报告首例先天性无丙种球蛋白血症（congenitalagammaglobulinemia）以来，全球报道的PID病例已愈万例，但其总发病率尚无确切资料。
O O O O O O O O O O O O O O O O O O O O O B-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis O B-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis O O O O O O O O O B-dis I-dis I-dis O O O O O O O O O O O O O O O O O O O O