（二）维生素B<sub>6<sub>依赖性小细胞低色素性贫血（三）高胱氨酸尿症患儿表现为智力低下、骨骼畸形、肌肉发育不良，其中80%患儿伴有视力障碍，30%患儿有类似Marfan综合征的心脏病。
O O O B-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis O O O B-dis I-dis I-dis I-dis I-dis I-dis O O O O O B-sym I-sym I-sym I-sym O B-sym I-sym I-sym I-sym O B-sym I-sym I-sym I-sym I-sym I-sym O O O O O O O O O O B-sym I-sym I-sym I-sym O O O O O O O O O B-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis O O O O O