现已发现：①淋巴细胞可产生一种29kd的多肽，其可导致肾小球滤过膜多阴离子减少，而出现蛋白尿；②刀豆素（ConA）刺激下的淋巴细胞可产生60～160kd的肾小球通透因子（glomerularpermeabilityfactor，GPF），GPF可直接引起蛋白尿；③淋巴细胞还可通过分泌12～18kd的可溶免疫反应因子（solubleimmuneresponsesuppressor，SIRS）而导致蛋白尿。
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