冷抗体型免疫性溶血性贫血可分为冷凝集素综合征（coldhemagglutininsyndrome）或冷凝集病和阵发性寒冷性血红蛋白尿；前者由病儿自身冷凝集素IgM引起，少数可由IgG或IgA引起；后者为IgG型冷抗体。
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