近年来，也从一些HUS患者中发现有补体调节因子基因突变现象，如补体因子H（complementfactorH，CFH）、补体因子Ⅰ（complementfactorⅠ，CFI）及补体膜辅助蛋白（membranecofactorprotein，MCP）基因。
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