nAChR特异CD4+</sup>T细胞先通过其受体（TCR）对nAChR特异性位点的识别，然后由T辅助细胞（Th）将nAChR主要免疫原区特异性抗体提供给B细胞，促使B细胞分泌高致病性的nAChRab。
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