LAC能与凝血酶原复合物中磷脂成分结合而抑制凝血作用，可能与SLE病人出血及凝血机制异常有关，实验发现aCL抗体有laG与IgM两种，IgG型与AID并流产、血栓形成及血小板减少有关；IgM型与AID并溶血性贫血、粒细胞减少、网状青斑及心内膜病变有关。
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