3.抗着丝点抗体是局限型SSc标记抗体，特别是CREST综合征时阳性。
O O B-bod I-bod I-bod I-bod I-bod I-bod O B-bod I-bod I-bod I-bod I-bod I-bod I-bod I-bod I-bod I-bod O O O O B-sym I-sym I-sym I-sym I-sym I-sym I-sym I-sym O O O O