本征患者PGI<sub>2</sub>低下，可能与发病有关，推测患儿缺少某种刺激产生PGI<sub>2</sub>的血浆因子或存在PGI<sub>2</sub>合成酶抑制物，尚有可能HUS患者对PGI<sub>2</sub>降解加快有关。
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