急性TIN常见高钾高氯性代谢性酸中毒，此由远端小管功能障碍所致；近端小管障碍则高氯性酸中毒、低磷血症和低尿酸血症，高氯性代谢性酸中毒为诊断急性TIN的重要线索，并有助于区别由急性肾小管坏死或急进性肾炎所致的急性肾衰竭。
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