肺炎链球菌产生的神经氨酸酶可分解掉N-乙酰神经氨酸，使被其掩盖的T-F抗原（Thomson-Friedenreich抗原）暴露于循环IgM抗体，IgM抗体与血小板和内皮细胞上的T-F抗原结合，导致血小板凝聚和内皮细胞损伤。
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