【发病机制】在吸入或食入链球菌后，细菌通过表面原纤维、细胞壁脂胞壁酸附着在呼吸道上皮细胞上，原纤维含有抗吞噬细胞的特异性M蛋白的抗原决定簇，M蛋白同荚膜透明质酸一起抵抗吞噬作用，细胞外消化性酶通过干扰局部血栓形成（链球菌素）和脓液形成（DNA酶）使得感染的蔓延加快；同时蛋白酶、透明质酸酶增加了对结缔组织的消化。
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