其发病机制系先天性外、中胚层发育障碍所致，与神经纤维瘤病和结节性硬化症同属斑痣性错构瘤病（phacomatosis）或母斑病。
O O O O O O B-sym I-sym I-sym I-sym I-sym I-sym I-sym I-sym I-sym I-sym I-sym I-sym O O O O B-dis I-dis I-dis I-dis I-dis I-dis O B-dis I-dis I-dis I-dis I-dis I-dis O O B-dis I-dis I-dis I-dis I-dis I-dis I-dis O B-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis I-dis O O B-dis I-dis I-dis O