近年的研究认为HUS发病机制涉及以下几个方面：1.内毒素及神经氨酸酶致内皮细胞受损EHEC在肠道内产生内毒素，主要有两种：一是志贺样毒素（shiga-liketoxin，SLT），又称维罗毒素（verotoxin，VT），可结合到内皮细胞表面的糖脂质受体（globotriaosylceramide，GB<sub>3</sub>）上，经吞噬进入胞质后分解为A链和B链。
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