临床发现伴发淋巴瘤的PID常为SCID、嘌呤核苷磷酸化酶（PNP）缺乏、XLA、X连锁淋巴组织增生症、高IgM血症（HM）、IgA缺乏症、IgG亚类缺陷、常见变异型免疫缺陷病（CVID）、湿疹血小板减少伴免疫缺陷（WAS）、毛细血管扩张共济失调综合征（AT）以及胸腺发育不全等。
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