Only a very rare affliction, of course, could bring about such vast and radical anatomical changes in a single individual after maturity—changes invoking osseous factors as basic as the shape of the skull—but then, even this aspect was no more baffling and unheard-of than the visible features of the malady as a whole. It would be hard, the youth implied, to form any real conclusions regarding such a matter; since one never came to know the natives personally no matter how long one might live in Innsmouth.