Alkyl-substituted imidazopyridines for the treatment of gastrointestinal disordersCompounds of the formula 1, in which the substituents and symbols are as defined in the description are suitable for pre-venting and treating gastrointestinal disorders.A compound of the formula 1 where R1 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7-cycloalkyl-1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxy-1-4C-alkyl, 1-4C-alkoxycarbonyl, 2-4C-alkenyl, 2-4C-alkynyl, fluoro-1-4C-alkyl or hydroxy-1-4C-alkyl, R2 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkyl-1-4C-alkyl, 1-4C-alkoxycarbonyl, hydroxy-1-4C-alkyl, halogen, 2-4C-alkenyl, 2-4C-alkynyl, fluoro-1-4C-alkyl or cyanomethyl, R3a is hydrogen, halogen, fluoro-1-4C-alkyl, 1-4C-alkyl, 2-4C-alkenyl, 2-4C-alkynyl, 1-4C-alkoxy, carboxyl, 1-4C-alkoxycarbonyl, hydroxy-1-4C-alkyl, 1-4C-alkoxy-1-4C-alkyl, 1-4C-alkoxy-1-4C-alkoxy-1-4C-alkyl, fluoro-1-4C-alkoxy-1-4C-alkyl or the radical —CO—NR31R32, R3b is hydrogen, halogen, fluoro-1-4C-alkyl, 1-4C-alkyl, 2-4C-alkenyl, 2-4C-alkynyl, 1-4C-alkoxy, carboxyl, 1-4C-alkoxycarbonyl, hydroxy-1-4C-alkyl, 1-4C-alkoxy-1-4C-alkyl, 1-4C-alkoxy-1-4C-alkoxy-1-4C-alkyl, fluoro-1-4C-alkoxy-1-4C-alkyl or the radical —CO—NR31R32, where R31 is hydrogen, 1-7C-alkyl, hydroxy-1-4C-alkyl or 1-4C-alkoxy-1-4C-alkyl and R32 is hydrogen, 1-7C-alkyl, hydroxy-1-4C-alkyl or 1-4C-alkoxy-1-4C-alkyl, or where R31 and R32 together and including the nitrogen atom to which they are attached form a pyrrolidino, piperidino or morpholino radical,  one of the substituents R4a and R4b is hydrogen and the other is the radical R41, where R41 is 1-7C-alkyl, 2-7C-alkenyl, 3-7C-cycloalkyl, 1-4C-alkoxy-1-4C-alkyl, cyano-1-4C-alkyl, phenyl or phenyl-1-4C-alkyl,  one of the substituents R5a and R5b is hydrogen and the other is hydroxyl, 1-4C-alkoxy, oxo-substituted 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkyl-1-4C-alkoxy, 1-4C-alkoxy-1-4C-alkoxy, 3-7C-cycloalkoxy-1-4C-alkoxy, 3-7C-cycloalkyl-1-4C-alkoxy-1-4C-alkoxy, 1-4C-alkylcarbonyloxy, fully or predominantly halogen-substituted 1-4C-alkoxy or the radical R51, where R51 is a radical which, under physiological conditions, forms a hydroxyl group,  Arom is a R8-, R9-, R10- and R11-substituted mono- or bicyclic aromatic radical selected from the group consisting of phenyl, naphthyl, pyrrolyl, pyrazolyl, imidazolyl, 1,2,3-triazolyl, indolyl, benzimidazolyl, furanyl (furyl), benzofuranyl (benzofuryl), thiophenyl (thienyl), benzothiophenyl (benzothienyl), thiazolyl, isoxazolyl, pyridinyl, pyrimidinyl, quinolinyl and isoquinolinyl, where R8 is hydrogen, 1-4C-alkyl, hydroxy-1-4C-alkyl, 1-4C-alkoxy, 2-4C-alkenyloxy, 1-4C-alkylcarbonyl, carboxyl, 1-4C-alkoxycarbonyl, carboxy-1-4C-alkyl, 1-4C-alkoxycarbonyl-1-4C-alkyl, halogen, hydroxyl, aryl, aryl-1-4C-alkyl, aryloxy, aryl-1-4C-alkoxy, trifluoromethyl, nitro, amino, mono- or di-1-4C-alkylamino, 1-4C-alkylcarbonylamino, 1-4C-alkoxycarbonylamino, 1-4C-alkoxy-1-4C-alkoxycarbonylamino or sulfonyl, R9 is hydrogen, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, halogen, trifluoromethyl or hydroxyl, R10 is hydrogen, 1-4C-alkyl or halogen and R11 is hydrogen, 1-4C-alkyl or halogen, where  aryl is phenyl or substituted phenyl having one, two or three identical or different substituents from the group consisting of 1-4C-alkyl, 1-4C-alkoxy, carboxyl, 1-4C-alkoxycarbonyl, halogen, trifluoromethyl, nitro, trifluoromethoxy, hydroxyl and cyano, X is O (oxygen) or NH, and its salts.
위장관계 장애의 치료를 위한 알킬 치환 이미다조피리딘본 명세서에서 정의된 치환체와 부호로 된 화학식 1의 화합물은 위장관계 장애의 예방 및 치료에 적당하다.화학식 1의 화합물 및 그것의 염: (1) 여기서, R1은 수소, 1-4C-알킬, 3-7C-시클로알킬, 3-7C-시클로알킬-1-4C-알킬, 1-4C-알콕시, 1-4C-알콕시-1-4C-알킬, 1-4C-알콕시카르보닐, 2-4C-알케닐, 2-4C-알키닐, 플루오로-1-4C-알킬 또는 히드록시-1-4C-알킬이고, R2는 수소, 1-4C-알킬, 3-7C-시클로알킬, 3-7C-시클로알킬-1-4C-알킬, 1-4C-알콕시카르보닐, 히드록시-1-4C-알킬, 할로겐, 2-4C-알케닐, 2-4C-알키닐, 플루오로-1-4C-알킬 또는 시아노메틸이고, R3a는 수소, 할로겐, 플루오로-1-4C-알킬, 1-4C-알킬, 2-4C-알케닐, 2-4C-알키닐, 1-4C-알콕시, 카르복실, 1-4C-알콕시카르보닐, 히드록시-1-4C-알킬, 1-4C-알콕시-1-4C-알킬, 1-4C-알콕시-1-4C-알콕시-1-4C-알킬, 플루오로-1-4C-알콕시-1-4C-알킬 또는 -CO-NR31R32 라디칼이고, R3b는 수소, 할로겐, 플루오로-1-4C-알킬, 1-4C-알킬, 2-4C-알케닐, 2-4C-알키닐, 1-4C-알콕시, 카르복실, 1-4C-알콕시카르보닐, 히드록시-1-4C-알킬, 1-4C-알콕시 -1-4C-알킬, 1-4C-알콕시-1-4C-알콕시-1-4C-알킬, 플루오로-1-4C-알콕시-1-4C-알킬 또는 -CO-NR31R32 라디칼이며, 여기서, R31는 수소, 1-7C-알킬, 히드록시-1-4C-알킬 또는 1-4C-알콕시-1-4C-알킬이고, R32는 수소, 1-7C-알킬, 히드록시-1-4C-알킬 또는 1-4C-알콕시-1-4C-알킬이고, 또는 여기서, 같이 그것이 부착되어 있는 질소 원자를 포함하는 R31과 R32는 피롤리디노, 피페리디노, 또는 모르폴리노 라디칼을 형성하고, 치환체 R4a와 R4b중 하나는 수소이고 나머지 하나는 라디칼 R41이며, 여기서 R41은 1-7C-알킬, 2-7C-알케닐, 3-7C-시클로알킬, 1-4C-알콕시-1-4C-알킬, 시아노-1-4C-알킬, 페닐 또는 페닐-1-4C-알킬이고, 치환체 R5a와 R5b중 하나는 수소이고 나머지 하나는 히드록실, 1-4C-알콕시, 옥소치환된 1-4C-알콕시, 3-7C-시클로알콕시, 3-7C-시클로알킬-1-4C-알콕시, 1-4C-알콕시-1-4C-알콕시, 3-7C-시클로알콕시-1-4C-알콕시, 3-7C-시클로알킬-1-4C-알콕시-1-4C-알콕시, 1-4C-알킬카르보닐옥시, 완전히 또는 우세하게 할로겐 치환된 1-4C-알콕시 또는 라디칼 R51이며, 여기서 R51은 생리학적 조건에서 히드록실기를 형성하는 라디칼이며, Arom은 페닐, 나프틸, 피롤릴, 피라졸릴, 이미다졸릴, 1,2,3-트리아졸릴, 인돌릴, 벤즈이미다졸릴, 퓨라닐(퓨릴), 벤조퓨라닐(벤조퓨릴), 티오페닐(티에닐), 벤조티오페닐(벤조티에닐), 티아졸릴, 이소옥사졸릴, 피리디닐, 피리미디닐, 퀴놀리닐 그리고 이소퀴놀리닐로 구성된 군으로부터 선택된 R8-, R9-, R10- 그리고 R11-치환된 모노- 또는 비시클릭 방향족 라디칼이며, 여기서 R8은 수소, 1-4C-알킬, 히드록시-1-4C-알킬, 1-4C-알콕시, 2-4C-알케닐옥시, 1-4C-알킬카르보닐, 카르복실, 1-4C-알콕시카르보닐, 카르복시-1-4C-알킬, 1-4C-알콕시카르보닐-1-4C-알킬, 할로겐, 히드록실, 아릴, 아릴-1-4C-알킬, 아릴옥시, 아릴-1-4C-알콕시, 트리플루오로메틸, 니트로, 아미노, 모노- 또는 디-1-4C-알킬아미노, 1-4C-알킬카르보닐아미노, 1-4C-알콕시카르보닐아미노, 1-4C-알콕시-1-4C-알콕시카르보닐아미노 또는 설포닐이고, R9는 수소, 1-4C-알킬, 1-4C-알콕시, 1-4C-알콕시카르보닐, 할로겐, 트리플루오로메틸 또는 히드록실이고, R10은 수소, 1-4C-알킬 또는 할로겐 그리고 R11은 수소, 1-4C-알킬 또는 할로겐이며, 여기서, 아릴은 페닐 또는 1-4C-알킬, 1-4C-알콕시, 카르복실, 1-4C-알콕시카르보닐, 할로겐, 트리플루오로메틸, 니트로, 트리플루오로메톡시, 히드록실 그리고 시아노로 구성된 군에서 하나, 둘, 또는 세개의 동일한 또는 다른 치환체를 갖는 치환된 페닐이고, X는 산소 또는 NH이다.