Terpenoidic derivatives (sarcodictyins) useful as antitumor agentsThe present invention relates to terpenoidic derivatives, known in the art as Sarcodictyins, for use as therapeutic agents, and to pharmaceutical compositions containing them. In particular, Sarcodictyins can be useful as therapeutic antineoplastic agents in the treatment of cancers in human or animal beings.One kind is selected from down the chemical compound of organizing as therapeutic agent: (e)-and 3-(1-methyl isophthalic acid h-imidazoles-4 base) acrylic acid (-)-(4r, 4ar, 7r, 10s, 11s, 12as, 1z, 5e, 8z)-7,10-epoxy-3,4,4a, 7,10,11,12,12a-octahydro-7-hydroxyl-6-(methoxycarbonyl)-1,10-dimethyl-4-(1-methylethyl) benzo ring ten-11-base ester (sarcodictyins a);(e)-3-(1-ylmethyl-1h-imidazoles-4 base) acrylic acid (-)-(4r, 4ar, 7r, 10s, 11s, 12as, 1z, 5e, 8z)-7,10-epoxy-6-(ethoxy carbonyl)-3,4,4a, 7,10,11,12,12a-octahydro-7-hydroxyl-1,10-dimethyl-4-(1-methylethyl) benzo ring ten-11-base ester (sarcodictyins b);(e)-3-(1-methyl isophthalic acid h-imidazoles-4 base) acrylic acid (-)-(3r, 4s, 4ar, 7s, 10r, 11r, 12as, 1z, 5e, 8z)-7,10-epoxy-3,4,4a, 7,10,11,12,12a-octahydro-3,7-dihydroxy-6-(methoxycarbonyl)-1,10-dimethyl-4-(1-methylethyl) benzo ring ten-11-base ester (sarcodictyinsc);(e)-3-(1-methyl isophthalic acid h-imidazoles-4 base) acrylic acid (-)-(3r, 4s, 4ar, 7s, 10r, 11r, 12as, 1z, 5e, 8z)-3-acetoxyl group-7,10-epoxy-3,4,4a, 7,10,11,12,12a-octahydro-7-hydroxyl-6-(methoxycarbonyl)-1,10-dimethyl-4-(1-methylethyl) benzo ring ten-11-base ester (sarcodictyinsd);(z)-3-(1-methyl isophthalic acid h-imidazoles-4 base) acrylic acid (+)-(3r, 4s, 4ar, 7s, 10r, 11r, 12as, 1z, 5e, 8z)-7,10-epoxy-3,4,4a, 7,10,11,12,12a-octahydro-3,7-dihydroxy-6-(methoxycarbonyl)-1,10-dimethyl-4-(1-methylethyl) benzo ring ten-11-base ester (sarcodictyinse); with(e)-3-(1-methyl isophthalic acid h-imidazoles-4 base) acrylic acid (+)-(1r, 4r, 4ar, 7r, 10s, 11s, 12as, 2z, 5e, 8z)-7,10-epoxy-1,4,4a, 7,10,11,12,12a-octahydro-1,7-dihydroxy-6-(methoxycarbonyl)-1,10-dimethyl-4-(1-methylethyl) benzo ring ten-11-base ester (sarcodictyinsf).
항종양제로서 유용한 테르페노이딕 유도체 (사르코딕타인) (TERPENOIDIC DERIVATIVES (SARCODICTYINS) USEFUL AS ANTITUMOR AGENTS)본 발명은 치료제로 사용되는 사르코딕타인으로서, 당분야에 공지된 테르페노이딕 유도체, 및 이들을 함유하는 약제학적 조성물에 관한 것이다. 특히,사르코틱타인은 인간 또는 동물의 암 치료에서 항종양 치료제로서 유용하게 사용될수 있다.치료제로 사용되는 하기로 이루어진 군으로부터 선택된 화합물:(-)-(4R,4aR,7R,10S,11S,12aR,1Z,5E,8Z)-7,10-에폭시-3,4,4a,7,10,11,12,12a-옥타히드로-7-히드록시-6-(메톡시카르보닐)-1,10,-디메틸-4-(1-메틸에틸)벤조시클로데센-11-일 (E)-3-(1-메틸-1H-이미다졸 4-일)아크릴레이트사르코딕타인A):(-)-(4R,4aR,7R,10S,11S,12aR,1Z,,5E,8Z)-7-10-에폭시-6-(에톡시카르보닐)3,4,4a,7,10,11,12,12a-옥타히드로-7-히드록시-1,10-디메틸-4-(1-메틸에틸)벤조시클로데센-11-일(E)-3-(1-메틸-1H-이미다졸-4-일)아크릴레이트(사르코딕타인 B) : (-)-(3R,4S,4aR,7S,10R,11R,12aS,1Z,5E,8Z)-7,10-에폭시-3,4,4a,7,10,11,12,12a-옥타히드로-3,7-디히드록시-6-(메톡시카르보닐)-1,10-디메틸-4-(1-메틸에틸)벤조시클로데센-11-일 (E)-3-(1-메틸-1H-이미다졸-4-일)아크릴레이트(사르코딕타인 C: (-)-(3R,4S,4aR,7S,10R,11R,12aS,1Z,5E,8Z)-3-아세톡시-7,10-에폭시-3,4,4a,7,10,11,12,12a-옥타히드로-7-히드록시-6-(메톡시카르보닐)-1,10-디메틸-4-(1-메틸에틱)벤조시클로데센-11-일(E)-3-(1-메틸-1H-이미다졸-4-일)아크릴레이트(사르코딕타인D); (+)-(3R,4S,4aR,7S,10R,11R,12aS,1Z,5E,8Z)-7,10-에폭시-3,4,4a,7,10,11,12,12a-옥타히드로-3,7-디히드록시-6-(메톡시카르보닐)-1,10-디메틸-4-(1-메틸에틸)벤조시클로데센-11-일 (Z)-3-1(1-메틸-1H-이미다졸-4-일)아크릴레이트(사르코딕타인 E); 및 (+)-(1R,4R,4aR,7R,10S,11S,12aR,2Z,5E,8Z)-7,10-에폭시-1,4,4a,7,10,11,12,12a-옥타히드로-1,7-디히드록시-6-(메톡시카르보닐)-1,10-디메틸-4-(1-메틸에틸)벤조시클로데센-11-일 (E)-3-(1-메틸-1H-이미다졸-4-일)아크릴레이트(사르코딕타인F).