NEW BICYCLIC COMPOUNDS AS DUAL ATX/CA INHIBITORSThe invention provides novel compounds having the general formula (I) wherein R1, R2,Y, W, m, n, p and q are as defined herein, compositions including the compounds and methods of using the compounds.The compound of formula (i)whereinr1it is phenyl, the phenyl-c of substitution of substitution1-6- alkyl, the phenoxy group-c of substitution1-6- alkyl, the phenyl-c of substitution2-6- alkene base, the phenyl-c of substitution2-6- alkynyl, the quinolyl of substitution, the quinolyl-c of substitution1-6- alkyl, the quinolyl-c of substitution1-6- alkene base, the quinolyl-c of substitution1-6- alkynyl, the pyridine radicals of substitution, the pyridine radicals-c of substitution1-6- alkyl, the pyridine radicals-c of substitution2-6- alkenyl, the pyridine radicals-c of substitution2-6- alkynyl, the thienyl of substitution, the thienyl-c of substitution1-6- alkyl, the thienyl substituted- c2-6- alkenyl or substituted thienyl-c2-6- alkynyl, wherein the phenyl substituted, the phenyl-c of substitution1-6- alkyl, the benzene oxygen of substitution base-c1-6- alkyl, the phenyl-c of substitution2-6- alkenyl, the phenyl-c of substitution2-6- alkynyl, the quinolyl of substitution, the quinoline of substitution base-c1-6- alkyl, the quinolyl-c of substitution1-6- alkenyl, the quinolyl-c of substitution1-6- alkynyl, the pyridine radicals of substitution, the pyrrole of substitution piperidinyl-c1-6- alkyl, the pyridine radicals-c of substitution2-6- alkenyl, the pyridine radicals-c of substitution2-6- alkynyl, substitution thienyl, substitution thienyl-c1-6- alkyl, the thienyl-c of substitution2-6- alkenyl and the thienyl-c of substitution2-6- alkynyl is by r3、r4and r5substitution；y be-oc (o)-or-c (o)-；w be-c (o)-,-s (o)2- or-cr6r7-；r2be substitution phenyl, substitution pyridine radicals or substituted thienyl, wherein the phenyl substituted, substitution pyridine radicals and take the thienyl in generation is by r6、r7and r8substitution；r3it is halogen, hydroxyl, cyano group, c1-6- alkyl, c1-6- alkoxy, c1-6- alkoxy -c1-6- alkyl, halo-c1-6- alcoxyl base, halo-c1-6- alkyl, hydroxyl-c1-6- alkyl, c3-8- cycloalkyl, c3-8- cycloalkyl-c1-6- alkyl, c3-8- cycloalkyl-c1-6- alkoxy, c3-8- cycloalkyloxy, c3-8- cycloalkyloxy-c1-6- alkyl, c1-6- alkyl amino, c1-6- alkyl-carbonyl-amino, c3-8- cycloalkyl amino carbonyl, c1-6- alkyl tetrazole radical, c1-6- alkyl tetrazole radical-c1-6- alkyl or heterocyclylalkyl-c1-6- alkoxy；r4and r5independently selected from h, halogen, hydroxyl, cyano group, c1-6- alkyl, c1-6- alkoxy, c1-6- alkoxy -c1-6- alkyl, halo-c1-6- alkoxy, halo-c1-6- alkyl, hydroxyl-c1-6- alkyl, c3-8- cycloalkyl, c3-8- cycloalkyl-c1-6- alkyl, c3-8- cycloalkyl-c1-6- alkoxy, c3-8- cycloalkyloxy, c3-8- cycloalkyloxy-c1-6- alkyl, c1-6- alkyl-carbonyl-amino, c3-8- cycloalkyl amino carbonyl, c1-6- alkyl tetrazole radical, c1-6- alkyl tetrazole radical-c1-6- alkyl or heterocyclylalkyl-c1-6- alcoxyl base；r6it is amino-sulfonyl；r7and r8independently selected from h, halogen, hydroxyl, cyano group, c1-6- alkyl, c1-6- alkoxy, c1-6- alkoxy -c1-6- alkyl, halo-c1-6- alkoxy, halo-c1-6- alkyl, hydroxyl-c1-6- alkyl, c3-8- cycloalkyl, c3-8- cycloalkyl-c1-6- alkyl, c3-8- cycloalkyl-c1-6- alkoxy, c3-8- cycloalkyloxy and c3-8- cycloalkyloxy-c1-6- alkyl；m, n, p and q are independently selected from 1 or 2；and pharmaceutical salts.
이중 오토탁신(ATX)/탄산 무수화효소(CA) 억제제로서 신규한 이환형 화합물본 발명은 신규한 하기 화학식 I의 화합물, 상기 화합물을 포함하는 조성물, 및 상기 화합물의 사용 방법을 제공한다: [화학식 I][이미지] 상기 식에서, R1, R2, Y, W, m, n, p 및 q는 본원에 정의된 바와 같다.하기 화학식 I의 화합물 또는 이의 약학적으로 허용되는 염:[화학식 I][이미지]상기 식에서,R1은 치환된 페닐, 치환된 페닐-C1-6-알킬, 치환된 페녹시-C1-6-알킬, 치환된 페닐-C2-6-알켄일, 치환된 페닐-C2-6-알킨일, 치환된 퀴놀린일, 치환된 퀴놀린일-C1-6-알킬, 치환된 퀴놀린일-C1-6-알켄일, 치환된 퀴놀린일-C1-6-알킨일, 치환된 피리딘일, 치환된 피리딘일-C1-6-알킬, 치환된 피리딘일-C2-6-알켄일, 치환된 피리딘일-C2-6-알킨일, 치환된 티오페닐, 치환된 티오페닐-C1-6-알킬, 치환된 티오페닐-C2-6-알켄일 또는 치환된 티오페닐-C2-6-알킨일이되, 치환된 페닐, 치환된 페닐-C1-6-알킬, 치환된 페녹시-C1-6-알킬, 치환된 페닐-C2-6-알켄일, 치환된 페닐-C2-6-알킨일, 치환된 퀴놀린일, 치환된 퀴놀린일-C1-6-알킬, 치환된 퀴놀린일-C1-6-알켄일, 치환된 퀴놀린일-C1-6-알킨일, 치환된 피리딘일, 치환된 피리딘일-C1-6-알킬, 치환된 피리딘일-C2-6-알켄일, 치환된 피리딘일-C2-6-알킨일, 치환된 티오페닐, 치환된 티오페닐-C1-6-알킬, 치환된 티오페닐-C2-6-알켄일 및 치환된 티오페닐-C2-6-알킨일은 R3, R4 및 R5로 치환되고;Y는 -OC(O)- 또는 -C(O)-이고;W는 -C(O)-, -S(O)2- 또는 -CR6R7-이고;R2는 치환된 페닐, 치환된 피리딘일 또는 치환된 티오페닐이되, 치환된 페닐, 치환된 피리딘일 및 치환된 티오페닐은 R6, R7 및 R8으로 치환되고;R3는 할로겐, 하이드록시, 시아노, C1-6-알킬, C1-6-알콕시, C1-6-알콕시-C1-6-알킬, 할로-C1-6-알콕시, 할로-C1-6-알킬, 하이드록시-C1-6-알킬, C3-8-사이클로알킬, C3-8-사이클로알킬-C1-6-알킬, C3-8-사이클로알킬-C1-6-알콕시, C3-8-사이클로알콕시, C3-8-사이클로알콕시-C1-6-알킬, C1-6-알킬아미노, C1-6-알킬카본일아미노, C3-8-사이클로알킬카본일아미노, C1-6-알킬테트라졸릴, C1-6-알킬테트라졸릴-C1-6-알킬 또는 헤테로사이클로알킬-C1-6-알콕시이고;R4 및 R5는 독립적으로 H, 할로겐, 하이드록시, 시아노, C1-6-알킬, C1-6-알콕시, C1-6-알콕시-C1-6-알킬, 할로-C1-6-알콕시, 할로-C1-6-알킬, 하이드록시-C1-6-알킬, C3-8-사이클로알킬, C3-8-사이클로알킬-C1-6-알킬, C3-8-사이클로알킬-C1-6-알콕시, C3-8-사이클로알콕시, C3-8-사이클로알콕시-C1-6-알킬, C1-6-알킬카본일아미노, C3-8-사이클로알킬카본일아미노, C1-6-알킬테트라졸릴, C1-6-알킬테트라졸릴-C1-6-알킬 또는 헤테로사이클로알킬-C1-6-알콕시로부터 선택되고;R6는 아미노설폰일이고;R7 및 R8은 독립적으로 H, 할로겐, 하이드록시, 시아노, C1-6-알킬, C1-6-알콕시, C1-6-알콕시-C1-6-알킬, 할로-C1-6-알콕시, 할로-C1-6-알킬, 하이드록시-C1-6-알킬, C3-8-사이클로알킬, C3-8-사이클로알킬-C1-6-알킬, C3-8-사이클로알킬-C1-6-알콕시, C3-8-사이클로알콕시 및 C3-8-사이클로알콕시-C1-6-알킬로부터 선택되고;m, n, p 및 q는 독립적으로 1 또는 2로부터 선택된다.