SUBSTITUTED 1,1,1-TRIFLUORO-3-[(BENZYL)-(PYRIMIDIN-2-YL)-AMINO]-PROP AN-2-OL COMPOUNDSSubstituted 1,1,1-trifluoro-3-[(benzyl)-(pyrimidin-2-yl)-amino]-propan-2-ol compounds, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.A compound of the Formula I Formula I or a pharmaceutically acceptable salt of said compound wherein;R1 is 5-bromo-2-fluorophenoxy, 4-bromo-3-fluorophenoxy, 4-bromophenoxy, 4-butoxyphenoxy, 2- chlorophenoxy, 3-chlorophenoxy, 4-chloro-3-ethylphenoxy, 4-chloro-3-methylphenoxy, 2-chloro-4- fluorophenoxy, 4-chloro-2-fluorophenoxy, 4-chlorophenoxy, 3-chloro-4-ethylphenoxy, 3-chloro-4- methylphenoxy, 3-chloro-4-fluorophenoxy, 4-chloro-3-fluorophenoxy, 2,3-dichlorophenoxy, 2,4- dichlorophenoxy, 3,4-dichlorophenoxy, 3,4-difluorophenoxy, 3,5-difluorophenoxy, 2,3-difluorophenoxy, 2,4- difluorophenoxy, 2,5-difluorophenoxy, 3,5-dimethoxyphenoxy, 3-dimethylaminophenoxy, 3,5- dimethylphenoxy, 3,4-dimethylphenoxy, 2-ethylphenoxy, 3-ethylphenoxy, 4-ethylphenoxy, A- ethylaminophenoxy, 3-ethyl-5-methylphenoxy, 2-fluoro-3-methylphenoxy, 3-fluoro-4-methylphenoxy, 3- fluorophenoxy, 3-fluoro-2-nitrophenoxy, 2-fluorophenoxy, 4-fluoro-3-methylphenoxy, 4-fluorophenoxy, 2- fluoro-3-trifluoromethylphenoxy, 2-fIuoro-4-trifluoromethylphenoxy, 3-isopropylphenoxy, 4-isopropyl-3- methylphenoxy, 2-methylphenoxy, 3-methylphenoxy, 3-methyl-4-methylthiophenoxy, 4-methylphenoxy, A- methylthiophenoxy, 3-methoxyphenoxy, 2-naphthyloxy, 2-nitrophenoxy, 4-nitrophenoxy, phenoxy, A- propylphenoxy, 4-propoxyphenoxy, 3-tert-butylphenoxy, 4-tert-butylphenoxy, 2-(5,6,7,8-tetrahydronaphthyl)- oxy, 4-trifluoromethoxyphenoxy, 3-trifluoromethoxyphenoxy, 4-trifluoromethylphenoxy, 3- trifluoromethylphenoxy, 2,3,4-trifluorophenoxy, 2,3,5-trifluorophenoxy, 3,4,5-trimethylphenoxy, 3- difluoromethoxyphenoxy, 3-pentafluoroethylphenoxy, 3-(1 ,1 ,2,2-tetrafluoroethoxy)phenoxy or 3- trifluoromethylthiophenoxy; and R2 is 1 ,1 ,2,2-tetrafluoroethoxy, pentafluoroethyl, trifluoromethoxy, or trifluoromethyl.
치환된1,1,1-트리플루오로-3-[(벤질)-(피리미딘-2-일)-아미노]-프로판-2-올 화합물본 발명은 치환된 1,1,1-트리플루오로-3-[(벤질)-(피리미딘-2-일)-아미노]-프로판-2-올 화합물, 이러한 화합물을 함유하는 약제학적 조성물, 및 고밀도 지단백질-콜레스테롤을 포함하는 특정의 혈장 지질 수준을 상승시키고, LDL-콜레스테롤 및 트리글리세라이드와 같은 그 밖의 다른 특정의 혈장 지질 수준을 저하시키고, 이에 따라 인간을 포함한 특정의 포유동물에서 아테롬성경화증 및 심혈관 질환과 같은, HDL 콜레스테롤의 낮은 수준 및/또는 LDL-콜레스테롤 및 트리글리세라이드의 높은 수준에 의해서 악화되는 질환을 치료하는 이러한 화합물의 용도에 관한 것이다.하기 화학식 I의 화합물 또는 그의 약제학적으로 허용되는 염: <화학식 I>  상기 식에서 R1은 5-브로모-2-플루오로페녹시, 4-브로모-3-플루오로페녹시, 4-브로모페녹시, 4-부톡시페녹시, 2-클로로페녹시, 3-클로로페녹시, 4-클로로-3-에틸페녹시, 4-클로로-3-메틸페녹시, 2-클로로-4-플루오로페녹시, 4-클로로-2-플루오로페녹시, 4-클로로페녹시, 3-클로로-4-에틸페녹시, 3-클로로-4-메틸페녹시, 3-클로로-4-플루오로페녹시, 4-클로로-3-플루오로페녹시, 2,3-디클로로페녹시, 2,4-디클로로페녹시, 3,4-디클로로페녹시, 3,4-디플루오로페녹시, 3,5-디플루오로페녹시, 2,3-디플루오로페녹시, 2,4-디플루오로페녹시, 2,5-디플루오로페녹시, 3,5-디메톡시페녹시, 3-디메틸아미노페녹시, 3,5-디메틸페녹시, 3,4-디메틸페녹시, 2-에틸페녹시, 3-에틸페녹시, 4-에틸페녹시, 4-에틸아미노페녹시, 3-에틸-5-메틸페녹시, 2-플루오로-3-메틸페녹시, 3-플루오로-4-메틸페녹시, 3-플루오로페녹시, 3-플루오로-2-니트로페녹시, 2-플루오로페녹시, 4-플루오로-3-메틸페녹시, 4-플루오로페녹시, 2-플루오로-3-트리플루오로메틸페녹시, 2-플루오로-4-트리플루오로메틸페녹시, 3-이소프로필페녹시, 4-이소프로필-3-메틸페녹시, 2-메틸페녹시, 3-메틸페녹시, 3-메틸-4-메틸티오페녹시, 4-메틸페녹시, 4-메틸티오페녹시, 3-메톡시페녹시, 2-나프틸옥시, 2-니트로페녹시, 4-니트로페녹시, 페녹시, 4-프로필페녹시, 4-프로폭시페녹시, 3-tert-부틸페녹시, 4-tert-부틸페녹시, 2-(5,6,7,8-테트라하이드로나프틸)-옥시, 4-트리플루오로메톡시페녹시, 3-트리플루오로메톡시페녹시, 4-트리플루오로메틸페녹시, 3-트리플루오로메틸페녹시, 2,3,4-트리플루오로페녹시, 2,3,5-트리플루오로페녹시, 3,4,5-트리메틸페녹시, 3-디플루오로메톡시페녹시, 3-펜타플루오로에틸페녹시, 3-(1,1,2,2-테트라플루오로에톡시)페녹시 또는 3-트리플루오로메틸티오페녹시이고; R2는 1,1,2,2-테트라플루오로에톡시, 펜타플루오로에틸, 트리플루오로메톡시 또는 트리플루오로메틸이다.