PROPHYLACTIC OR THERAPEUTIC AGENT FOR DELIRIUMThe present invention provides a prophylactic or therapeutic agent for delirium containing compound (I) having melatonin receptor affinity. A compound represented by the formula:  wherein each symbol is as described in the specification, or a salt thereof.A prophylactic or therapeutic agent for delirium comprising a compound selected from N-[2-(2-methyl-6,7-dihydro-8H-indeno[5,4-d][1,3]oxazol-8-ylidene)ethyl]acetamide, N-[2-(2-methyl-6H-indeno[5,4-d][1,3]oxazol-8-yl)ethyl]acetamide, N-[2-(2-methyl-6,7-dihydro-8H-indeno[5,4-d][1,3]oxazol-8-ylidene)ethyl]propionamide, N-{2-[2-(4-phenylbutyl)-6,7-dihydro-8H-indeno[5,4-d][1,3]oxazol-8-ylidene]ethyl}acetamide, N-[2-(2-methyl-6,7-dihydro-8H-indeno[5,4-d][1,3]thiazol-8-ylidene)ethyl]acetamide, N-[2-(2-methyl-7,8-dihydro-6H-indeno[5,4-d][1,3]oxazol-8-yl)ethyl]acetamide, (R)-N-[2-(2-methyl-7,8-dihydro-6H-indeno[5,4-d][1,3]oxazol-8-yl)ethyl]acetamide, (S)-N-[2-(2-methyl-7,8-dihydro-6H-indeno[5,4-d][1,3]oxazol-8-yl)ethyl]acetamide, N-[2-(2-methyl-7,8-dihydro-6H-indeno[5,4-d][1,3]oxazol-8-yl)ethyl]propionamide, (R)-N-[2-(2-methyl-7,8-dihydro-6H-indeno[5,4-d][1,3]oxazol-8-yl)ethyl]propionamide, (S)-N-[2-(2-methyl-7,8-dihydro-6H-indeno[5,4-d][1,3]oxazol-8-yl)ethyl]propionamide, N-[2-(2-methyl-7,8-dihydro-6H-indeno[5,4-d][1,3]thiazol-8-yl)ethyl]acetamide, (R)-N-[2-(2-methyl-7,8-dihydro-6H-indeno[5,4-d][1,3]thiazol-8-yl)ethyl]acetamide, (S)-N-[2-(2-methyl-7,8-dihydro-6H-indeno[5,4-d][1,3]thiazol-8-yl)ethyl]acetamide, N-[2-(2-ethyl-7,8-dihydro-6H-indeno[5,4-d][1,3]oxazol-8-yl)ethyl]acetamide, (R)-N-[2-(2-ethyl-7,8-dihydro-6H-indeno[5,4-d][1,3]oxazol-8-yl)ethyl]acetamide, (S)-N-[2-(2-ethyl-7,8-dihydro-6H-indeno[5,4-d][1,3]oxazol-8-yl)ethyl]acetamide, N-[2-(2-methoxy-7,8-dihydro-6H-indeno[5,4-d][1,3]oxazol-8-yl)ethyl]acetamide, (R)-N-[2-(2-methoxy-7,8-dihydro-6H-indeno[5,4-d][1,3]oxazol-8-yl)ethyl]acetamide, and (S)-N-[2-(2-methoxy-7,8-dihydro-6H-indeno[5,4-d][1,3]oxazol-8-yl)ethyl]acetamide or a salt thereof as an active ingredient.
섬망의 예방 또는 치료제본 발명은 멜라토닌 수용체 친화성을 갖는 화합물 (I) 을 함유하는, 섬망의 예방 또는 치료제를 제공한다. 하기 식: (식 중, 각 기호는 명세서에서 정의하는 바와 같다) 로 표시되는 화합물 또는 이의 염.N-[2-(2-메틸-6,7-디히드로-8H-인데노[5,4-d][1,3]옥사졸-8-일리덴)에틸]아세트아미드,N-[2-(2-메틸-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]아세트아미드,N-[2-(2-메틸-6,7-디히드로-8H-인데노[5,4-d][1,3]옥사졸-8-일리덴)에틸]프로피온아미드,N-{2-[2-(4-페닐부틸)-6,7-디히드로-8H-인데노[5,4-d][1,3]옥사졸-8-일리덴]에틸}아세트아미드,N-[2-(2-메틸-6,7-디히드로-8H-인데노[5,4-d][1,3]티아졸-8-일리덴)에틸]아세트아미드,N-[2-(2-메틸-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]아세트아미드,(R)-N-[2-(2-메틸-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]아세트아미드,(S)-N-[2-(2-메틸-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]아세트아미드,N-[2-(2-메틸-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]프로피온아미드,(R)-N-[2-(2-메틸-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]프로피온아미드,(S)-N-[2-(2-메틸-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]프로피온아미드,N-[2-(2-메틸-7,8-디히드로-6H-인데노[5,4-d][1,3]티아졸-8-일)에틸]아세트아미드,(R)-N-[2-(2-메틸-7,8-디히드로-6H-인데노[5,4-d][1,3]티아졸-8-일)에틸]아세트아미드,(S)-N-[2-(2-메틸-7,8-디히드로-6H-인데노[5,4-d][1,3]티아졸-8-일)에틸]아세트아미드,N-[2-(2-에틸-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]아세트아미드,(R)-N-[2-(2-에틸-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]아세트아미드,(S)-N-[2-(2-에틸-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]아세트아미드,N-[2-(2-메톡시-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]아세트아미드,(R)-N-[2-(2-메톡시-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]아세트아미드, 및(S)-N-[2-(2-메톡시-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]아세트아미드에서 선택되는 화합물 또는 이의 염을 유효 성분으로서 포함하는, 섬망의 예방 또는 치료제.