BICYCLIC COMPOUNDS AS ATX INHIBITORSThe invention provides novel compounds having the general formula (I), (I) wherein R1, R2, R9, Y, W, m, n, p and q are as defined herein, compositions including the compounds and methods of using thecompounds.The compound of formula (i)whereinr1it is phenyl, the phenyl-c of substitution of substitution1-6- alkyl, the phenoxy group-c of substitution1-6- alkyl, the phenyl-c of substitution2-6- alkene base, the phenyl-c of substitution2-6- alkynyl, the pyridine radicals of substitution, the pyridine radicals-c of substitution1-6- alkyl, the pyridine radicals-c of substitution2-6- alkene base, the pyridine radicals-c of substitution2-6- alkynyl, the thienyl of substitution, the thienyl-c of substitution1-6- alkyl, the thienyl-c of substitution2-6- alkenyl or substituted thienyl-c2-6- alkynyl, wherein the phenyl substituted, the phenyl-c of substitution1-6- alkyl, the phenoxy group substituted- c1-6-alkyl, the phenyl-c of substitution2-6- alkenyl, the phenyl-c of substitution2-6- alkynyl, substitution pyridine radicals, substitution pyridine radicals- c1-6- alkyl, the pyridine radicals-c of substitution2-6- alkenyl, the pyridine radicals-c of substitution2-6- alkynyl, the thienyl of substitution, the thiophene of substitution base-c1-6- alkyl, the thienyl-c of substitution2-6- alkenyl and the thienyl-c of substitution2-6- alkynyl is by r3、r4and r5substitution；y be-oc (o)-or-c (o)-；w be-c (o)-,-s (o)2- or-cr6r7-；r2selected from loop system b, f, l, m, o, z, af, ag, ah, aj, an, ao, ap, aq, ar, as, at, au and av：r3it is halogen, hydroxyl, cyano group, c1-6- alkyl, c1-6- alkoxy, c1-6- alkoxy -c1-6- alkyl, halo-c1-6- alcoxyl base, halo-c1-6- alkyl, hydroxyl-c1-6- alkyl, c3-8- cycloalkyl, c3-8- cycloalkyl-c1-6- alkyl, c3-8- cycloalkyl-c1-6- alkoxy, c3-8- cycloalkyloxy, c3-8- cycloalkyloxy-c1-6- alkyl, c1-6- alkyl amino, c1-6- alkyl-carbonyl-amino, c3-8- cycloalkyl amino carbonyl, c1-6- alkyl tetrazole radical, c1-6- alkyl tetrazole radical-c1-6- alkyl or heterocyclylalkyl-c1-6- alkoxy；r4and r3independently selected from h, halogen, hydroxyl, cyano group, c1-6- alkyl, c1-6- alkoxy, c1-6- alkoxy -c1-6- alkyl, halo-c1-6- alkoxy, halo-c1-6- alkyl, hydroxyl-c1-6- alkyl, c3-8- cycloalkyl, c3-8- cycloalkyl-c1-6- alkyl, c3-8- cycloalkyl-c1-6- alkoxy, c3-8- cycloalkyloxy, c3-8- cycloalkyloxy-c1-6- alkyl, c1-6- alkyl-carbonyl-amino, c3-8- cycloalkyl amino carbonyl, c1-6- alkyl tetrazole radical, c1-6- alkyl tetrazole radical-c1-6- alkyl or heterocyclylalkyl-c1-6- alcoxyl base；r6it is h or c1-6- alkyl；r7it is h, c1-6- alkyl, halogen, halo-c1-6- alkyl or c1-6- alkoxy；r9it is halogen, c1-6alkyl or c1-6alkoxy；m, n, p and q are independently selected from 1 or 2；r is 1,2 or 3；or pharmaceutical salts.
오토탁신(ATX) 억제제로서의 이환형 화합물본 발명은 신규한 하기 화학식 I의 화합물, 상기 화합물을 포함하는 조성물, 및 상기 화합물의 사용 방법을 제공한다: [화학식 I][이미지] 상기 식에서, R1, R2, R9, Y, W, m, n, p 및 q는 본원에 정의된 바와 같다.하기 화학식 I의 화합물 또는 이의 약학적으로 허용가능한 염:[이미지]상기 식에서,R1은 치환된 페닐, 치환된 페닐-C1-6-알킬, 치환된 페녹시-C1-6-알킬, 치환된 페닐-C2-6-알켄일, 치환된 페닐-C2-6-알킨일, 치환된 피리딘일, 치환된 피리딘일-C1-6-알킬, 치환된 피리딘일-C2-6-알켄일, 치환된 피리딘일-C2-6-알킨일, 치환된 티오페닐, 치환된 티오페닐-C1-6-알킬, 치환된 티오페닐-C2-6-알켄일 또는 치환된 티오페닐-C2-6-알킨일이고, 이때 치환된 페닐, 치환된 페닐-C1-6-알킬, 치환된 페녹시-C1-6-알킬, 치환된 페닐-C2-6-알켄일, 치환된 페닐-C2-6-알킨일, 치환된 피리딘일, 치환된 피리딘일-C1-6-알킬, 치환된 피리딘일-C2-6-알켄일, 치환된 피리딘일-C2-6-알킨일, 치환된 티오페닐, 치환된 티오페닐-C1-6-알킬, 치환된 티오페닐-C2-6-알켄일 및 치환된 티오페닐-C2-6-알킨일은 R3, R4 및 R5로 치환되고;Y는 -OC(O)- 또는 -C(O)-이고;W는 -C(O)-, -S(O)2- 또는 -CR6R7-이고;R2는 하기 고리 시스템 B, F, L, M, O, Z, AF, AG, AH, AJ, AN, AO, AP, AQ, AR, AS, AT, AU 및 AV로부터 선택되고:[이미지][이미지];R3은 할로겐, 하이드록시, 시아노, C1-6-알킬, C1-6-알콕시, C1-6-알콕시-C1-6-알킬, 할로-C1-6-알콕시, 할로-C1-6-알킬, 하이드록시-C1-6-알킬, C3-8-사이클로알킬, C3-8-사이클로알킬-C1-6-알킬, C3-8-사이클로알킬-C1-6-알콕시, C3-8-사이클로알콕시, C3-8-사이클로알콕시-C1-6-알킬, C1-6-알킬아미노, C1-6-알킬카본일아미노, C3-8-사이클로알킬카본일아미노, C1-6-알킬테트라졸일, C1-6-알킬테트라졸일-C1-6-알킬 또는 헤테로사이클로알킬-C1-6-알콕시이고;R4 및 R5는 독립적으로 H, 할로겐, 하이드록시, 시아노, C1-6-알킬, C1-6-알콕시, C1-6-알콕시-C1-6-알킬, 할로-C1-6-알콕시, 할로-C1-6-알킬, 하이드록시-C1-6-알킬, C3-8-사이클로알킬, C3-8-사이클로알킬-C1-6-알킬, C3-8-사이클로알킬-C1-6-알콕시, C3-8-사이클로알콕시, C3-8-사이클로알콕시-C1-6-알킬, C1-6-알킬카본일아미노, C3-8-사이클로알킬카본일아미노, C1-6-알킬테트라졸일, C1-6-알킬테트라졸일-C1-6-알킬 또는 헤테로사이클로알킬-C1-6-알콕시로부터 선택되고;R6은 H 또는 C1-6-알킬이고;R7은 H, C1-6-알킬, 할로겐, 할로-C1-6-알킬 또는 C1-6-알콕시이고;R9는 할로겐, C1-6-알킬 또는 C1-6-알콕시이고;m, n, p 및 q는 독립적으로 1 또는 2로부터 선택되고;r은 1, 2 또는 3이다.