INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOFNovel compounds are disclosed that inhibit binding of LFA-1 to a natural ligand binding partner. Uses of the compounds are also provided.A compound selected from the group consisting of: 3-Chloro-4-(2-chlorophenylsulfanyl)-phenylamine hydrochloride 3-Chloro-4-(2-naphthylsulfanyl)-phenylamine hydrochloride3-Chloro-4-(2J-dichlorophenylsulfanyl)-phenylamine hydrochloride 3-Chloro-4-(2,4,5-trichlorophenylsulfanyl)-phenylamine hydrochloride 3-Chloro-4-(2,4-dichlorophenylsulfanyl)-phenylamine hydrochloride 3-Methoxy-4-(2J-dichlorophenylsulfanyl)-phenylamine 5- Amino-2-(2J-dichlorophenylsulfanyl)-acetophenone hydrochloride4-(2J-dichlorophenylsulfanyl)-phenylamine 3-Chloro-4-( 1 -naphthylsulfanyl)-phenylamine hydrochloride 3-Methyl-4-(2,4-dichlorophenylsulfanyl)-phenylamine hydrochloride l-Acetamido-3-chloro-4-(2J-dichlorophenylsulfanyl)-benzene 4-Methylamino-2J',4'-trichlorodiphenylsulfide3-Bromo-4-(2,4-dichlorophenylsulfanyl)-phenylamine hydrochloride3 -Hydroxy-4-(2J -dichlorophenylsulfanyl)-phenylamine hydrochloride6-Chloro-5-(2,4-dichlorophenylsulfanyl)-lH-benzimidazole4- Amino-2-chlorophenyl-(2'4'-dimethylphenyl)-sulfide hydrochloride 2,5-Dichloro-4-(2,4-dichlorophenylsulfanyl)-phenylamine hydrochloride4-Amino-2-chlorophenyl-(2'-methyl-4'-chlorophenyl)-sulfide 4- Amino-2-chlorophenyl-(2',4'-difluorophenyl)-sulfide hydrochloride 4-amino-2-chlorophenyl-(2',4',6'-trichlorophenyl)-sulfide 4-Amino-2-chlorophenyl-(2'-amino-4'-chlorophenyl)-sulfide 4- Amino-2-chlorophenyl-(2 ' -chloro-4 ' -nitrophenyl)-sulfide4-Amino-2-chlorophenyl-(2'-nitro-4'-chlorophenyl)-sulfide 4-Amino-2-chlorophenyl-(3',4-dichlorophenyl)-sulfide 4-Amino-2-chlorophenyl-2-(3-chloro-5-trifluoromethylpyridyl)-sulfide Rw-(4,4'-diamino-2J'-dichlorophenyl)-sulfide 4-Amino-2-chlorophenyl-(2',4'-dichlorophenyl)-sulfide4-Amino-2-chlorophenyl-(4'-acetamido-2 ' -chlorophenyl)-sulfide -Amino-2-chlorophenyl-6-(5-nitroquinolino)-sulfide -Amino-2-chlorophenyl-(4'-dimethylamino-2'-chlorophenyl)-sulfide -Chloro-4-amino-5-methylaminophenyl-(2',4'-dichlorophenyl)-sulfide -Chloro-4-amino-5-moφholinophenyl-(2',4'-dichlorophenyl)-sulfide -Amino-2-trifluoromethylphenyl-(2',4'-dichlorophenyl)-sulfide -Aminomethyl-2-chlorophenyl-(2 ' 4 ' -dichlorophenyl)-sulfide ,5-Dichloro-2-(2,4-dichlorophenylsulfanyl)-phenylamine ,5-Dichloro-4-(2,4-dichlorophenylsulfanyl)-phenylamine J-Dichloro-4-(2,4-dichlorophenylsulfanyl)-phenylamine -Amino-2-fluorophenyl-(2',4'-dichlorophenyl)-sulfide -Amino-3-chlorophenyl-(2',4'-dichlorophenyl)-sulfide -Nitro-2-chlorophenyl-(2',4'-dimethylphenyl)-sulfide -Nitro-2-chlorophenyl-(2'-methyl-4'-chlorophenyl)-sulfide -Nitro-2-chlorophenyl-(2', 4'-difluorophenyl)-sulfide -Nitro-2-chlorophenyl-(2', 4', 6'-trichlorophenyl)-sulfide -Nitro-2-chlorophenyl-(3 ', 4'-dichlorophenyl)-sulfide -Nitro-2-chlorophenyl-2-(3-chloro-5-trifluoromethylpyridyl)-sulfide -Chloro-4-nitrophenyl-(2', 4'-dichlorophenyl)-sulfide -Nitro-2-chlorophenyl-(4 ' -acetamido-2 ' -chlorophenyl)-sulfide -Nitro-2-chlorophenyl-(4'-dimethylamino-2'-chlorophenyl)-sulfide -Chloro-4-nitro-5-methylaminophenyl-(2', 4'-dichlorophenyl)-sulfide -Chloro-4-nitro-5-moφholinophenyl-(2', 4'-dichlorophenyl)-sulfide -Nitro-2-trifluoromethylphenyl-(2 ' , 4 '-dichlorophenyl)-sulfide -Nitro-2-fluorophenyl-(2 ', 4'-dichlorophenyl)-sulfide -Chloro-5-nitrophenyl-(2', 4'-dichlorophenyl)-sulfide -Nitro-2-chlorophenyl-( 1 -naphthyl)-sulfide -Nitro-2-methylphenyl-(2 ' , 4 ' -dichlorophenyl)-sulfide -Nitro-2-bromophenyl-(2 ' , 4 ' -dichlorophenyl)-sulfide -Nitro-2, 5-dichlorophenyl-(2', 4'-dichlorophenyl)-sulfide -Nitro-2, 6-dichlorophenyl-(2', 4'-dichlorophenyl)-sulfide -Nitro-2-chloro-5 -fluorophenyl-(2 ' , 4 ' -dichlorophenyl)-sulfide 4-Nitro-2, 3-dichlorophenyl-(2', 4'-dichlorophenyl)-sulfide 4-Nitro-2-chlorophenyl-(4'-chloro-2'-aminophenyl)-sulfide 4-Nitro-5-acetamido-2-chlorophenyl-(2', 4'-dichlorophenyl)-sulfide 4-Nitro-2-chlorophenyl-(4'-methylamino-2'-chlorophenyl)-sulfide 4-Nitro-2-chlorophenyl-(4'-benzylamino-2'-chlorophenyl)-sulfide4-Nitro-2-chlorophenyl-(4'-dibenzylamino-2'-chlorophenyl)-sulfide 4-Nitro-5-phenylsulfo-2-chlorophenyl-(2', 4'-dichlorophenyl)-sulfide 3-Nitro-5-chlorophenyl-(2', 4'-dichlorophenyl)-sulfide
ＬＦＡ-1의 ＩＣＡＭ에 대한 결합 저해제 및 그 용도 LFA-1가 천연 리간드 결합 파트너에 결합하는 것을 저해하는 신규의 화합물이 개시되어 있다. 이 화합물의 용도도 제공되어 있다.  3-클로로-4-(2-클로로페닐설파닐)-페닐아민 히드로클로라이드 3-클로로-4-(2-나프틸설파닐)-페닐아민 히드로클로라이드 3-클로로-4-(2,3-디클로로페닐설파닐)-페닐아민 히드로클로라이드 3-클로로-4-(2,4,5-트리클로로페닐설파닐)-페닐아민 히드로클로라이드 3-클로로-4-(2,4-디클로로페닐설파닐)-페닐아민 히드로클로라이드 3-메톡시-4-(2,3-디클로로페닐설파닐)-페닐아민 5-아미노-2-(2,3-디클로로페닐설파닐)-아세토페논 히드로클로라이드 4-(2,3-디클로로페닐설파닐)-페닐아민 3-클로로-4-(1-나프틸설파닐)-페닐아민 히드로클로라이드 3-메틸-4-(2,4-디클로로페닐설파닐)-페닐아민 히드로클로라이드 1-아세트아미도-3-클로로-4-(2,3-디클로로페닐설파닐)-벤젠 4-메틸아미노-2,2',4'-트리클로로디페닐설파이드 3-브로모-4-(2,4-디클로로페닐설파닐)-페닐아민 히드로클로라이드 3-히드록시-4-(2,3-디클로로페닐설파닐)-페닐아민 히드로클로라이드 6-클로로-5-(2,4-디클로로페닐설파닐)-1H-벤즈이미다졸 4-아미노-2-클로로페닐-(2' 4'-디메틸페닐)-설파이드 히드로클로라이드 2,5-디클로로-4-(2,4-디클로로페닐설파닐)-페닐아민 히드로클로라이드 4-아미노-2-클로로페닐-(2'-메틸-4'-클로로페닐)-설파이드 4-아미노-2-클로로페닐-(2',4'-디플루오로페닐)-설파이드 히드로클로라이드 4-아미노-2-클로로페닐-(2',4',6'-트리클로로페닐)-설파이드 4-아미노-2-클로로페닐-(2'-아미노-4'-클로로페닐)-설파이드 4-아미노-2-클로로페닐-(2'-클로로-4'-니트로페닐)-설파이드 4-아미노-2-클로로페닐-(2'-니트로-4'-클로로페닐)-설파이드 4-아미노-2-클로로페닐-(3',4-디클로로페닐)-설파이드 4-아미노-2-클로로페닐-2-(3-클로로-5-트리플루오로메틸피리딜)-설파이드 비스-(4,4'-디아미노-2,2'-디클로로페닐)-설파이드 4-아미노-2-클로로페닐-(2',4'-디클로로페닐)-설파이드 4-아미노-2-클로로페닐-(4'-아세트아미도-2'-클로로페닐)-설파이드 4-아미노-2-클로로페닐-6-(5-니트로퀴놀리노)-설파이드 4-아미노-2-클로로페닐-(4'-디메틸아미노-2'-클로로페닐)-설파이드 2-클로로-4-아미노-5-메틸아미노페닐-(2',4'-디클로로페닐)-설파이드 2-클로로-4-아미노-5-모르폴리노페닐-(2',4'-디클로로페닐)-설파이드 4-아미노-2-트리플루오로메틸페닐-(2',4'-디클로로페닐)-설파이드 4-아미노메틸-2-클로로페닐-(2',4'-디클로로페닐)-설파이드 4,5-디클로로-2-(2,4-디클로로페닐설파닐)-페닐아민 3,5-디클로로-4-(2,4-디클로로페닐설파닐)-페닐아민 2,3-디클로로-4-(2,4-디클로로페닐설파닐)-페닐아민 4-아미노-2-플루오로페닐-(2',4'-디클로로페닐)-설파이드 5-아미노-3-클로로페닐-(2',4'-디클로로페닐)-설파이드 4-니트로-2-클로로페닐-(2',4'-디메틸페닐)-설파이드 4-니트로-2-클로로페닐-(2'-메틸-4'-클로로페닐)-설파이드 4-니트로-2-클로로페닐-(2',4'-디플루오로페닐)-설파이드 4-니트로-2-클로로페닐-(2',4',6'-트리클로로페닐)-설파이드 4-니트로-2-클로로페닐-(3',4'-디클로로페닐)-설파이드 4-니트로-2-클로로페닐-2-(3-클로로-5-트리플루오로메틸피리딜)-설파이드 2-클로로-4-니트로페닐-(2',4'-디클로로페닐)-설파이드 4-니트로-2-클로로페닐-(4'-아세트아미도-2'-클로로페닐)-설파이드 4-니트로-2-클로로페닐-(4'-디메틸아미노-2'-클로로페닐)-설파이드 2-클로로-4-니트로-5-메틸아미노페닐-(2',4'-디클로로페닐)-설파이드 2-클로로-4-니트로-5-모르폴리노페닐-(2',4'-디클로로페닐)-설파이드 4-니트로-2-트리플루오로메틸페닐-(2',4'-디클로로페닐)-설파이드 4-니트로-2-플루오로페닐-(2',4'-디클로로페닐)-설파이드 3-클로로-5-니트로페닐-(2',4'-디클로로페닐)-설파이드 4-니트로-2-클로로페닐-(1-나프틸)-설파이드 4-니트로-2-메틸페닐-(2',4'-디클로로페닐)-설파이드 4-니트로-2-브로모페닐-(2',4'-디클로로페닐)-설파이드 4-니트로-2,5-디클로로페닐-(2',4'-디클로로페닐)-설파이드 4-니트로-2,6-디클로로페닐-(2',4'-디클로로페닐)-설파이드 4-니트로-2-클로로-5-플루오로페닐-(2',4'-디클로로페닐)-설파이드 4-니트로-2,3-디클로로페닐-(2',4'-디클로로페닐)-설파이드 4-니트로-2-클로로페닐-(4'-클로로-2'-아미노페닐)-설파이드 4-니트로-5-아세트아미도-2-클로로페닐-(2',4'-디클로로페닐)-설파이드 4-니트로-2-클로로페닐-(4'-메틸아미노-2'-클로로페닐)-설파이드 4-니트로-2-클로로페닐-(4'-벤질아미노-2'-클로로페닐)-설파이드 4-니트로-2-클로로페닐-(4'-디벤질아미노-2'-클로로페닐)-설파이드 4-니트로-5-페닐설포-2-클로로페닐-(2',4'-디클로로페닐)-설파이드 3-니트로-5-클로로페닐-(2',4'-디클로로페닐)-설파이드 로 구성된 군에서 선택된 화합물.