Steroidal glycosides for treating hypercholesterolemiaCertain steroidal glycosides are useful as hypocholesterolemic agents and antiatherosclerosis agents.Spirostanyl glycosides (formula ia),q 4and q 5be methylene radical; and whereinr 1be β-d-glucopyranosyl, β-d-pyranose aldehydic acid glucosyl,β-d-2-acetylaminohydroxyphenylarsonic acid 2-deoxidation-glucopyranosyl,β-d-galactopyranose base,β-d-pyrans fucosido,β-l-pyrans fucosido,β-d-xylopyranosyl,β-l-xylopyranosyl,α-d-pyrans arabinan base,α-l-pyrans arabinan base,α-d-cellobiosyl,β-d-cellobiosyl,β-d-lactose base,β-d-malt-base,β-d-gentiobiose base,3-o-β-d-galactopyranose base-α-d-pyrans arabinan base, orβ-d-maltotriose glycosyl;perhaps (b):q 1, q 4and q 5be methylene radical; and whereinr 1be β-d-glucopyranosyl, β-d-pyranose aldehydic acid glucosyl,β-d-2-acetylaminohydroxyphenylarsonic acid 2-deoxidation-glucopyranosyl,β-d-pyrans fucosido,β-l-pyrans fucosido,β-d-xylopyranosyl,β-l-xylopyranosyl,α-d-pyrans arabinan base,α-l-pyrans arabinan base,β-d-cellobiosyl,β-d-lactose base,β-d-malt-base,β-d-gentiobiose base,3-o-β-d-galactopyranose base-α-d-pyrans arabinan base, orβ-d-maltotriose glycosyl;perhaps (c):q 1, q 4and q 5be methylene radical; c 25be the r configuration and whereinr 1be β-d-pyranose aldehydic acid glucosyl, β-d-2-acetylaminohydroxyphenylarsonic acid 2-deoxidation-glucopyranosyl,β-d-pyrans fucosido,β-l-pyrans fucosido,β-d-xylopyranosyl,β-l-xylopyranosyl,α-d-pyrans arabinan base,α-l-pyrans arabinan base,β-d-cellobiosyl,β-d-lactose base,β-d-malt-base,β-d-gentiobiose base,3-o-β-d-galactopyranose base-α-d-pyrans arabinan base, orβ-d-maltotriose glycosyl;perhaps (d):q 1, q 2, q 4and q 5be methylene radical; withq 3for r 1the o-alkylidene group orr 1the o-alkylidene group and whereinr 1be β-d-2-acetylaminohydroxyphenylarsonic acid 2-deoxidation-glucopyranosyl, β-d-pyrans fucosido,β-d-xylopyranosyl,β-l-xylopyranosyl,α-l-pyrans arabinan base,β-d-cellobiosyl,β-d-gentiobiose base,3-o-β-d-galactopyranose base-α-d-pyrans arabinan base, orβ-maltotriose glycosyl;perhaps (e):q 1, q 2and q 5be methylene radical; q 4for carbonyl or q 3for c 5be the α type; c 25be the r configuration and whereinr 1be β-d-galactopyranose base, β-d-cellobiosyl,β-d-lactose base,β-d-malt-base, orβ-d-maltotriose glycosyl;perhaps (f):q 1, q 2and q 4the methylene radical of respectively doing for oneself; q 5for carbonyl or q 3for c 5be the α type; c 25be the r configuration and whereinr 1be β-d-galactopyranose base, β-d-cellobiosyl,β-d-lactose base,β-d-malt-base, orβ-d-maltotriose glycosyl;condition be do not comprise (3 β, 5 α, 25r)-3-[(β-d-cellobiosyl) oxygen] spirostane.
콜레스테롤과잉혈증 치료용 스테로이드성 글리코사이드(STEROLDAL GLYCOSIDES FOR TREATING HYPERCHOLESTEROLEMIA)특정 스테로이드성 글리콜사이드는 저콜레스테롤혈증제 및 항죽상동맥경화증제로서 유용하다.하기 일반식(IA)의 스피로스타닐 글리코사이드: [이미지] [이미지] [이미지]이고, Q4및 Q5는 모두 메틸렌이고, 여기서, R1은 [이미지]-D-클루코피라노실, [이미지]-D-클루코피라누로노실, [이미지]-D-2-아세트아미도-2-데옥시-글루코피라노실, [이미지]-D-갈락토피라노실, [이미지]-D-푸코피라노실, [이미지]-L-푸코피라노실, [이미지]-D-크실로피나노실, [이미지]-L-크실로피나로실, [이미지]-D-아라바노피라노실, [이미지]-L-아라바노피라노실, [이미지]-D-셀로비오실, [이미지]-D-셀로비오실, [이미지]-D-락토실, [이미지]-D-말토실, [이미지]-D-젠티오비오실 3-0-[이미지]-D-갈락토피라노실-[이미지]-D-아라바노피라노실 또는 [이미지]-D-말토트리오실이거나, 또는 (B) : Q1, Q4및 Q5가 모두 메틸렌이고, Q2는 [이미지] 또는 [이미지][이미지]이고; 여기서, R1은 [이미지]-D-글루코피라노실, [이미지]-D-글루코피라누로노실, [이미지]-D-2-아세트아미도-2-데옥시-글루코피라노실, [이미지]-D-푸코피라노실, [이미지]-L-푸코피라노실, [이미지]-D-크실로피나노실, [이미지]-L-크실로피나로실, [이미지]-D-아라바노피라노실, [이미지]-L-아라바노피라노실, [이미지]-D-셀로비오실, [이미지]-D-셀로비오실, [이미지]-D-락토실, [이미지]-D-말토실, [이미지]-D-젠티오비오실, 3-0-[이미지]-D-갈락토피라노실-[이미지]-D-아라바노피라노실 또는 [이미지]-D-말토트리오실이거나, 또는 (C) : Q1, Q4및 Q5가 모두 메틸렌이고, Q2는 카보닐이고, Q3는[이미지]또는, [이미지]이고; C25는 (R)이고, 여기서, R1은 [이미지]-D-클루코피라누로노실, [이미지]-D-2-아세트아미도-2-데옥시-글루코피라노실, [이미지]-D-푸코피라노실, [이미지]-L-푸코피라노실, [이미지]-D-크실로피나노실, [이미지]-L-크실로피나로실, [이미지]-D-아라바노피라노실, [이미지]-L-아라바노피라노실, [이미지]-D-셀로비오실, [이미지]-D-셀로비오실, [이미지]-D-락토실, [이미지]-D-말토실, [이미지]-D-젠티오비오실 3-0-[이미지]-D-갈락토피라노실-[이미지]-D-아라바노피라노실 또는 [이미지]-D-말토트리오실이거나, 또는 (D) : Q1, Q4및 Q5가 모두 메틸렌이고, Q3는 [이미지]여기서, R1은[이미지]-D-2-아세트아미도-2-데옥시-글루코피라노실, [이미지]-D-푸코피라노실, [이미지]-D-크실로피나노실, [이미지]-L-크실로피나로실, [이미지]-L-아라바노피라노실, [이미지]-D-셀로비오실, [이미지]-D-젠티오비오실, 3-0-[이미지]-D-갈락토피라노실-[이미지]-D-아라바노피라노실 또는 [이미지]-D-말토트리오실이거나, 또는 (E) : Q1, Q4및 Q5는 각각 메틸렌이고, Q4는 카보닐 또는[이미지]이고; C5는 알파이고; C25는 (R)이고; 여기서, R1은[이미지]-D-갈락토피라노실, [이미지]-D-셀로비오실, [이미지]-D-락토실, [이미지]-D-말토실 또는 [이미지]-D-말토트리오실이나, 또는 (F) : Q1, Q42및 Q4는 각각 메틸렌이고, Q3는[이미지][이미지]이고, Q5는 카보닐 또는 [이미지]이고 C5는 알파이고; C25는 (R)이고; 여기서, R1은[이미지]-D-갈락토피라노실, [이미지]-D-셀로비오실, [이미지]-D-락토실, [이미지]-D-말토실 또는 [이미지]-D-말토트리오실이나, 단, 상기 화합물은 (3β,5[이미지],25R)-3-[([이미지]-D-셀로비오실)옥시)스피로스탄을 포함하지 않는다.