Macrophage scavenger receptor antagonistsMacrophage scavenger receptor antagonists are provided. Methods of treating cardiovascular disease comprising administration of the present compounds are also provided. The present compounds inhibit lipid accumulation within macrophage-derived foam cells.Be selected from following compound: n-phenyl-2-(3-trifluoromethyl sulfonamido) benzamide, 5-bromo-n-(3, the 4-dichlorophenyl)-2-(3-trifluoromethyl sulfonamido) benzamide, n-(4-chlorphenyl)-2-(2-fluorophenyl sulfonamido) benzamide, 5-bromo-n-(3-trifluoromethyl)-2-(5-chloro-2-thienyl sulfonamido) benzamide, 5-chloro-n-(4-chlorphenyl)-2-(5-chloro-2-thienyl sulfonamido) benzamide, n-(3-chloro-4-methoxyphenyl)-2-(4-methoxyphenyl sulfonamido) benzamide, n-phenyl-2-(2-fluorophenyl sulfonamido) benzamide, n-(4-chlorphenyl-2-(3-trifluoromethyl sulfonamido) benzamide, n-phenyl-2-(4-methoxyphenyl sulfonamido) benzamide, n-(4-chlorphenyl-2-(3-trifluoromethyl sulfonamido)-4-methoxy benzamide, n-(3-chloro-4-methoxyphenyl-2-(3-trifluoromethyl sulfonamido)-4-methoxy benzamide, n-(3, the 4-dichlorophenyl)-2-(2-methyl fluoride phenyl sulfonamido)-5-methoxy benzamide, n-(4-chlorphenyl)-2-(3-trifluoromethyl sulfonamido)-5-methoxy benzamide, 5-chloro-n-(4-chlorphenyl)-2-(4-chlorphenyl sulfonamido) benzamide, 5-chloro-n-(4-chlorphenyl)-2-(3,3,3-trifluoroethyl sulfonamido) benzamide, n-(3, the 4-dichlorophenyl)-2-(phenyl sulfonamido)-5-methoxy benzamide, 2-(4-chlorphenyl sulfonamido)-n-(4-ethoxy carbonyl phenyl) benzamide, 5-bromo-n-phenyl-2-(2-fluorophenyl sulfonamido) benzamide, 5-bromo-n-phenyl-2-phenyl sulfonamido benzamide, 5-bromo-n-phenyl-2-(5-chloro-2-thienyl sulfonamido) benzamide, 5-bromo-n-(4-chlorphenyl-2-(5-chloro-2-thienyl sulfonamido) benzamide, 5-bromo-n-phenyl-2-(4-methoxyphenyl sulfonamido) benzamide, 5-bromo-n-(4-chlorphenyl)-2-(2-fluorophenyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(4-nitrobenzophenone sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(5-dimethylamino-1-naphthyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(phenyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(3,4-difluorophenyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(3-trifluoromethyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(normal-butyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(benzyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(8-isoquinolyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(2-fluorophenyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(2,1,3-diazosulfide-4-base sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(4-chlorphenyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(3-chloro-4-fluorophenyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(3-chloro-2-aminomethyl phenyl sulfonamido) benzamide and 5-bromo-n-(4-bromophenyl)-2-(2,4,6-trimethylphenyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(4-iodine substituted phenyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(3-chloropropyl sulfonamido) benzamide, n-(4-bromophenyl)-5-chloro-2-(4-trifluoromethoxyphen-l) benzamide, 5-bromo-n-(3-trifluoromethyl)-2-(3-trifluoromethyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(4-chlorphenyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(3-chloro-4-fluorophenyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(3-chloro-2-aminomethyl phenyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(2,4,6-trimethylphenyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(2-fluorophenyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(3,4-dimethoxyphenyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(4-phenylazo phenyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(4-trifluoromethyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(2-aminomethyl phenyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(phenyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(2-naphthyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(4-phenyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(3-chloropropyl sulfonamido) benzamide, 5-bromo-n-(4-bromophenyl)-2-(2-phenyl vinyl) benzamide, 5-bromo-n-(4-bromophenyl)-2-(4-iodophenyl sulfonamido) benzamide and 5-bromo-n-(4-bromophenyl)-2-(4-tert-butyl-phenyl sulfonamido) benzamide.
마크로파지 스캐빈저 수용체 길항제본 발명은 마크로파지 스캐빈저 수용체 길항제에 관한 것이다. 본 발명은 또한 본 발명의 화합물을 투여하는 것을 포함하는, 심혈관계 질환의 치료 방법에 관한 것이다. 본 발명의 화합물은 마크로파지-유도된 포말 세포내의 지질 축적을 억제한다.N-페닐-2-(3-트리플루오로메틸페닐술폰아미도)벤즈아미드, 5-브로모-N-(3,4-디클로로페닐)-2-(3-트리플루오로메틸페닐술폰아미도)벤즈아미드, N-(4-클로로페닐)-2-(2-플루오로페닐술폰아미도)벤즈아미드, 5-브로모-N-(3-트리플루오로메틸페닐)-2-(5-클로로-2-티에닐술폰아미도)벤즈아미드, 5-클로로-N-(4-클로로페닐)-2-(5-클로로-2-티에닐술폰아미도)벤즈아미드, N-(3-클로로-4-메톡시페닐)-2-(4-메톡시페닐술폰아미도)벤즈아미드, N-페닐-2-(2-플루오로페닐술폰아미도)벤즈아미드, N-(4-클로로페닐)-2-(3-트리플루오로메틸페닐술폰아미도)벤즈아미드, N-페닐-2-(4-메톡시페닐술폰아미도)벤즈아미드, N-(4-클로로페닐-2-(3-트리플루오로메틸페닐술폰아미도)-4-메톡시벤즈아미드, N-(3-클로로-4-메톡시페닐)-2-(3-트리플루오로메틸페닐술폰아미도)-4-메톡시벤즈아미드, N-(3,4-디클로로페닐)-2-(2-플루오로페닐술폰아미도)-5-메톡시벤즈아미드, N-(4-클로로페닐)-2-(3-트리플루오로메틸페닐술폰아미도)-5-메톡시벤즈아미드, 5-클로로-N-(4-클로로페닐)-2-(4-클로로페닐술폰아미도)벤즈아미드, 5-클로로-N-(4-클로로페닐)-2-(3,3,3-트리플루오로에틸술폰아미도)벤즈아미드, N-(3,4-디클로로페닐)-2-(페닐술폰아미도)-5-메톡시벤즈아미드, 2-(4-클로로페닐술폰아미도)-N-(4-에톡시카르보닐페닐)벤즈아미드, 5-브로모-N-페닐-2-(2-플루오로페닐술폰아미도)벤즈아미드, 5-브로모-N-페닐-2-페닐술폰아미도벤즈아미드, 5-브로모-N-페닐-2-(5-클로로-2-티에닐술폰아미도)벤즈아미드, 5-브로모-N-(4-클로로페닐)-2-(5-클로로-2-티에닐술폰아미도)벤즈아미드, 5-브로모-N-페닐-2-(4-메톡시페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-클로로페닐)-2-(2-플루오로페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(4-니트로페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(5-디메틸아미노-1-나프틸술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(3,4-디플루오로페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(3-트리플루오로메틸페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(n-부틸술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(벤질술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(8-이소퀴놀릴술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(2-플루오로페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(2,1,3-벤조티아디아졸-4-일술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(4-클로로페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(3-클로로-4-플루오로페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(3-클로로-2-메틸페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(2,4,6-트리메틸페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(4-요오도페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(3-클로로프로필술폰아미도)벤즈아미드, N-(4-브로모페닐)-5-클로로-2-(4-트리플루오로메톡시페닐)벤즈아미드, 5-브로모-N-(3-트리플루오로메틸페닐)-2-(3-트리플루오로메틸페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(4-클로로페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(3-클로로-4-플루오로페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(3-클로로-2-메틸페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(2,4,6-트리메틸페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(2-플루오로페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(3,4-디메톡시페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(4-페닐아조페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(4-트리플루오로메틸페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(2-메틸페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(2-나프틸술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(4-페닐페닐술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(3-클로로프로필술폰아미도)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(2-페닐비닐)벤즈아미드, 5-브로모-N-(4-브로모페닐)-2-(4-요오도페닐술폰아미도)벤즈아미드, 및 5-브로모-N-(4-브로모페닐)-2-(4-t-부틸페닐술폰아미도)벤즈아미드 로 이루어진 군으로부터 선택되는 화합물.