Substituted aniline derivativesThe present invention relates to aniline derivatives of the general formula I or salts thereof and their use.The compound or its salt of a tool general formula iwhereinz is o or s;andq is 0 or 1;andr 1and r 2independently be selected from halogen, cyano group, amino, c separately 1-6-alkane (alkene/alkynes) base, c 3-8-cycloalkanes (alkene) base, c 3-8-cycloalkanes (alkene) base-c 1-6-alkane (alkene/alkynes) base, c 3-8-heterocycle alkane (alkene) base, aryl, heteroaryl, halo-c 1-6-alkane (alkene/alkynes) base, halo-c 3-8-cycloalkanes (alkene) base, halo-c 3-8-cycloalkanes (alkene) base-c 1-6-alkane (alkene/alkynes) base, c 1-6the basic oxygen base of-alkane (alkene/alkynes), c 3-8the basic oxygen base of-cycloalkanes (alkene), c 3-8-cycloalkanes (alkene) base-c 1-6the basic oxygen base of-alkane (alkene/alkynes), c 3-8the basic oxygen base of-heterocycle alkane (alkene); andr 3be selected from c 1-8-alkane (alkene/alkynes) base, c 3-8-cycloalkanes (alkene) base, c 3-8-cycloalkanes (alkene) base-c 1-6-alkane (alkene/alkynes) base, aryl-c 1-6-alkane (alkene/alkynes) base, aryl-c 3-8-cycloalkanes (alkene) base, aryl-c 3-8-cycloalkanes (alkene) base-c 1-6-alkane (alkene/alkynes) base, c 3-8-heterocycle alkane (alkene) base-c 1-6-alkane (alkene/alkynes) base, c 1-6-alkane (alkene/alkynes) base-c 3-8-heterocycle alkane (alkene) base-c 1-6-alkane (alkene/alkynes) base, heteroaryl-c 1-6-alkane (alkene/alkynes) base, heteroaryl-c 3-8-cycloalkanes (alkene) base, heteroaryl-c 3-8-cycloalkanes (alkene) base-c 1-6-alkane (alkene/alkynes) base, amino-c 1-6-alkane (alkene/alkynes) base, amino-c 3-8-cycloalkanes (alkene) base, amino-c 3-8-cycloalkanes (alkene) base-c 1-6-alkane (alkene/alkynes) base, c 1-6the basic oxygen base-c of-alkane (alkene/alkynes) 1-6-alkane (alkene/alkynes) base, c 3-8the basic oxygen base-c of-cycloalkanes (alkene) 1-6-alkane (alkene/alkynes) base, c 3-8-cycloalkanes (alkene) base-c 1-6the basic oxygen base-c of-alkane (alkene/alkynes) 1-6-alkane (alkene/alkynes) base, halo-c 1-6-alkane (alkene/alkynes) base, halo-c 3-8-cycloalkanes (alkene) base and halo-c 3-8-cycloalkanes (alkene) base-c 1-6-alkane (alkene/alkynes) base; andr 4be selected from halogen, cyano group, c 1-6-alkane (alkene/alkynes) base, c 3-8-cycloalkanes (alkene) base, c 3-8-cycloalkanes (alkene) base-c 1-6-alkane (alkene/alkynes) base, c 3-8-heterocycle alkane (alkene) base, aryl, heteroaryl, aryl-c 1-6-alkane (alkene/alkynes) base, aryl-c 3-8-cycloalkanes (alkene) base, aryl-c 3-8-cycloalkanes (alkene) base-c 1-6-alkane (alkene/alkynes) base, aryl-c 3-8-heterocycle alkane (alkene) base, halo-c 1-6-alkane (alkene/alkynes) base, halo-c 3-8-cycloalkanes (alkene) base, halo-c 3-8-cycloalkanes (alkene) base-c 1-6-alkane (alkene/alkynes) base, halo-c 1-6-alkane (alkene/alkynes) base-c 3-8-heterocycle alkane (alkene) base-c 1-6-alkane (alkene/alkynes) base, nr 5r 6and r 7nh-c 1-6-alkane (alkene/alkynes) base; r wherein 5and r 6independently be selected from hydrogen, aryl-c 1-6-alkane (alkene/alkynes) base, aryl-c 3-8-cycloalkanes (alkene) base, aryl-c 3-8-cycloalkanes (alkene) base-c 1-6-alkane (alkene/alkynes) base, c 1-6-alkane (alkene/alkynes) base, c 3-8-cycloalkanes (alkene) base, c 3-8-cycloalkanes (alkene) base-c 1-6-alkane (alkene/alkynes) base, heteroaryl-c 1-6-alkane (alkene/alkynes) base, heteroaryl-c 3-8-cycloalkanes (alkene) base and heteroaryl-c 3-8-cycloalkanes (alkene) base-c 1-6-alkane (alkene/alkynes) base, condition is r 5and r 6be not hydrogen simultaneously; and r 7be selected from c 1-6-alkane (alkene/alkynes) base, c 3-8-cycloalkanes (alkene) base, c 3-8-cycloalkanes (alkene) base-c 1-6-alkane (alkene/alkynes) base, aryl, halo-c 1-6-alkane (alkene/alkynes) base, halo-c 3-8-cycloalkanes (alkene) base, halo-c 3-8-cycloalkanes (alkene) base-c 1-6-alkane (alkene/alkynes) base, aryl-c 1-6-alkane (alkene/alkynes) base, aryl-c 3-8-cycloalkanes (alkene) base and heteroaryl.
치환 아닐린 유도체본 발명은 KCNQ 칼륨 이온 통로 개방 활성과 관련된 일반식 (I) 의 아닐린 유도체 또는 그의 염, 및 그들의 용도에 관한 것이다. 일반식 I 의 화합물 또는 그의 염: [이미지] [식 중 Z 는 O 또는 S 이고; q 는 0 또는 1 이고; R1 및 R2 각각은 할로겐, 시아노, 아미노, C1-6-알크(엔/인)일, C3-8-시클로알크(엔)일, C3-8-시클로알크(엔)일-C1-6-알크(엔/인)일, C3-8-헤테로시클로알크(엔)일, 아릴, 헤테로아릴, 할로-C1-6-알크(엔/인)일, 할로-C3-8-시클로알크(엔)일, 할로-C3-8-시클로알크(엔)일-C1-6-알크(엔/인)일, C1-6-알크(엔/인)일옥시, C3-8-시클로알크(엔)일옥시, C3-8-시클로알크(엔)일-C1-6-알크(엔/인)일옥시, C3-8-헤테로시클로알크(엔)일옥시로 이루어지는 군으로부터 독립적으로 선택되고; R3 는 C1-8-알크(엔/인)일, C3-8-시클로알크(엔)일, C3-8-시클로알크(엔)일-C1-6-알크(엔/인)일, 아릴-C1-6-알크(엔/인)일, 아릴-C3-8-시클로알크(엔)일, 아릴-C3-8-시클로알크(엔)일-C1-6-알크(엔/인)일, C3-8-헤테로시클로알크(엔)일-C1-6-알크(엔/인)일, C1-6-알크(엔/인)일-C3-8-헤테로시클로알크(엔)일-C1-6-알크(엔/인)일, 헤테로아릴-C1-6-알크(엔/인)일, 헤테로아릴-C3-8-시클로알크(엔)일, 헤테로아릴-C3-8-시클로알크(엔)일-C1-6-알크(엔/인)일, 아미노-C1-6-알크(엔/인)일, 아미노-C3-8-시클로알크(엔)일, 아미노-C3-8-시클로알크(엔)일-C1-6-알크(엔/인)일, C1-6-알크(엔/인)일옥시-C1-6-알크(엔/인)일, C3-8-시클로알크(엔)일옥시-C1-6-알크(엔/인)일, C3-8-시클로알크(엔)일-C1-6-알크(엔/인)일옥시-C1-6-알크(엔/인)일, 할로-C1-6-알크(엔/인)일, 할로-C3-8-시클로알크(엔)일 및 할로-C3-8-시클로알크(엔)일-C1-6-알크(엔/인)일로 이루어지는 군으로부터 선택되고; R4 는 할로겐, 시아노, C1-6-알크(엔/인)일, C3-8-시클로알크(엔)일, C3-8-시클로알크(엔)일-C1-6-알크(엔/인)일, C3-8-헤테로시클로알크(엔)일, 아릴, 헤테로아릴, 아릴-C1-6-알크(엔/인)일, 아릴-C3-8-시클로알크(엔)일, 아릴-C3-8-시클로알크(엔)일-C1-6-알크(엔/인)일, 아릴-C3-8-헤테로시클로알크(엔)일, 할로-C1-6-알크(엔/인)일, 할로-C3-8-시클로알크(엔)일, 할로-C3-8-시클로알크(엔)일-C1-6-알크(엔/인)일, 할로-C1-6-알크(엔/인)일-C3-8-헤테로시클로알크(엔)일-C1-6-알크(엔/인)일, NR5R6 및 R7NH-C1-6-알크(엔/인)일로 이루어지는 군으로부터 선택되고; 여기서 R5 및 R6 는 수소, 아릴-C1-6-알크(엔/인)일, 아릴-C3-8-시클로알크(엔)일, 아릴-C3-8-시클로알크(엔)일-C1-6-알크(엔/인)일, C1-6-알크(엔/인)일, C3-8-시클로알크(엔)일, C3-8-시클로알크(엔)일-C1-6-알크(엔/인)일, 헤테로아릴-C1-6-알크(엔/인)일, 헤테로아릴-C3-8-시클로알크(엔)일 및 헤테로아릴-C3-8-시클로알크(엔)일-C1-6-알크(엔/인)일로 이루어지는 군으로부터 독립적으로 선택되고, 단, R5 및 R6 가 동시에 수소는 아니고; R7 은 C1-6-알크(엔/인)일, C3-8-시클로알크(엔)일, C3-8-시클로알크(엔)일-C1-6-알크(엔/인)일, 아릴, 할로-C1-6-알크(엔/인)일, 할로-C3-8-시클로알크(엔)일, 할로-C3-8-시클로알크(엔)일-C1-6-알크(엔/인)일, 아릴-C1-6-알크(엔/인)일, 아릴-C3-8-시클로알크(엔)일 및 헤테로아릴로 이루어지는 군으로부터 선택됨].