ANTIMICROBIAL MIXTURES COMPRISING AT LEAST ONE HYDROXYPHENONE DERIVATIVESuggested is a synergistic antimicrobial mixture comprising a hydroxyacetophenone and one additional antimicrobial agent. The mixture is particular useful for fighting Aspergillus brasiliensis.An antimicrobial mixture comprising or consisting of(a) a first antimicrobial agent selected from the group consisting of at least one ace tophenone derivative of formula (I)in whichRi stands for hydrogen or methyl, andR2 stands for hydrogen, hydroxyl or a -OCH3 group,or a cosmetically or pharmaceutically acceptable salt thereof, and(b) at least one second antimicrobial agent selected from the group consisting of pre servatives selected from the group consisting of and their mixtures.
적어도 하나의 하이드록시페논 유도체 (hydroxyphenone derivative) 를 포함하는 항균성 혼합물제안된 것은 하이드록시아세토페논 및 하나의 추가적인 항균제를 포함하는 시너지적 항균 혼합물이다. 혼합물은 Aspergillus brasiliensis 을 없애기 위해 특히 유용하다.항균성 (antimicrobial) 혼합물로서, (a) 적어도 하나의 식 (I) 의 아세토페논 유도체 (acetophenone derivative) 로 구성되는 그룹으로부터 선택되는 제 1 항균제 (antimicrobial agent) 로서, (I)R1 은 수소 (hydrogen) 또는 메틸기 (methyl) 를 나타내고, 그리고R2 는 수소, 히드록실 또는 -OCH3 기, 또는 화장용 (cosmetically) 또는 약학적으로 (pharmaceutically) 허용가능한 이들의 염을 나타내는, 상기 제 1 항균제; 및(b) 1-(3-클로로알릴)-3,5,7-트리아자-1-아조니아- 아다만탄 클로라이드 (1-(3-chloroallyl)-3,5,7-triaza-1-azonia-adamantane chloride), 1-(4-클로로페녹시)-1- (1H-이미다졸-1-일)-3,3-디메틸-2-부탄온 (1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone), 1-하이드록시-4-메틸-6-(2,4,4-트리메틸펜틸)-2(1H)-피리돈, 2-아미노 에탄올 (옥토피록스) (1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone, 2-aminoethanol (Octopirox)), 1,1'-메틸렌-비스(3-(1-하이드록시메틸-2,4-디옥시미다졸리딘-5-일)유레아) (1,1'-methylene-bis(3-(1-hydroxymethyl-2,4-dioximidazolidin-5-yl)urea)), 1,2-벤즈이소티아졸-3(2H)-온 (1,2-benzisothiazol-3(2H)-one), 1,2-데칸디올 (1,2-decanediol), 1,2-디브로모-2,4-디시아노부탄 (1,2-dibromo-2,4-dicyanobutane), 1,3-비스(하이드록시메틸)-1-(1,3,4-트리스(하이드록시-메틸)-2,5-디옥소이미다졸리딘-4-일)유레아 (디아졸리디닐 유레아) (1,3-bis(hydroxymethyl)-1-(1,3,4-tris(hydroxy-methyl)-2,5-dioxoimidazolidin-4-yl)urea, (Diazolidinyl Urea)), 1,3-비스-(하이드록시메틸)-5,5-디메틸-2,4-이미다졸리딘디온 (1,3-bis-(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione), 1,3-비스-(하이드록시메틸)-5,5-디메틸이미다졸리딘-2,4-디온 (1,3-Bis(hydroxy-methyl)-5,5-dimethylimidazolidine-2,4-dione), 1,5-펜탄디올 (1,5-pentanediol), 1,6-비스(4-아미디노-2-브로모페녹시)-n-헥산 (6-bis(4-amidino-2-bromophenoxy)-n-hexane) 및 이것의 염들, 1,6-비스(4-아미디노-페녹시)-n-헥산 (1,6-bis(4-amidino-phenoxy)-n-hexane) 및 이것의 염들, 1,6-헥산디올 (1,6-hexanediol), 1,8-옥탄디올 (1,8-octanediol), 10-운데실렌산 (10-undecylenic acid) 및 이것의 염들, 1-페녹시-프로판-2-올 (1-phenoxy-propan-2-ol), 2,2'-메틸렌-비스(6-브로모-4-클로로페놀) (2,2'-methylene-bis(6-bromo-4-chlorophenol)), 2,4,4'-트리클로로-2'-하이드록시-디페닐 에테르 (트리클로산) (2,4,4'-trichloro-2'-hydroxy-diphenyl ether (trichlosan)), 2,4-디클로로벤질 알코올, N-(4-클로로페닐)-N'-(3,4-디클로로페닐)-유레아) (2,4-dichlorobenzyl alcohol, N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)-urea), 2-벤질-4-클로로페놀 (2-benzyl-4-chlorophenol), 2-벤질헵탄-1-올 (2-Benzylheptan-1-ol), 2-브로모-2-(브롬메틸)펜탄디니트릴 (2-brom-2-(brommethyl)pentandinitril), 2-브로모-2-니트로-1,3-프로판디올 (브로노폴) (2-bromo-2-nitro-1,3-propanediol (Bronopol)), 2-부틸옥타노익산 (2-butyloctanoic acid), 2-클로로아세트아마이드 (2-chloroacetamide), 클로헥시딘 (chlorhexidine), 2-하이드록시바이페닐 에테르 (2-hydroxybiphenyl ether) 및 그것의 염들, 마그네슘 니트레이트 (magnesium nitrate) 및 마그네슘 클로라이드 (magnesium chloride) 와 2-메틸-3(2H)-이소티아졸리논 (2-methyl-3(2H)-isothiazolinone), 2-옥틸-2H-이소티아졸-3-온 (2-octyl-2H-isothiazol-3-one), 2-페녹시에탄올 (2-phenoxyethanol), 2-징크-설피도피리딘 N-옥사이드 (2-zinc-sulfidopyridine N-oxide), 2,4-헥사디에노익산 (소르빈산) (2,4-hexadienoic acid, sorbic acid) 및 이것의 염들 (예를 들어, 칼륨염 (potassium salt)), 3-(4-클로로페녹시)-1,2-프로판디올 (3-(4-chlorophenoxy)-1,2-propanediol), 3-(4-클로페녹시)-1,2-프로판디올 (클로페네신) (3-(4-Chlorphenoxy)-1,2-propanediol (Chlorphenesin)), 3-아세틸-2-하이드록시-6-메틸-4H-피란-4-온 (3-Acetyl-2-hydroxy-6-methyl-4H-pyran-4-one), 3-벤질옥시-프로판-1,2-디올 (3-benzyloxy-propan-1,2-diol), 3-아이오도-2-프로피닐 부틸카르바메이트 (3-iodo-2-propynyl butylcarbamate), 3-페녹시-프로판-1,2-디올 (3-phenoxy-propan-1,2-diol), 3-페녹시프로판올 (3-phenoxypropanol), 4,4-디메틸-1,3-옥사졸리딘 (4,4-dimethyl-1,3-oxazolidine), 4-클로로-3,5-디메틸페놀 (4-chloro-3,5-dimethylphenol), 4-클로로-m-크레졸 (4-chloro-m-cresol), 4-에틸수은-(II)5-아미노-1,3-비스(2-하이드록시벤조산) (4-ethylmercury-(II)5-amino-1,3-bis(2-hydroxybenzoic acid)), 이것의 염들 및 에스테르들, 4-하이드록시 벤즈알데하이드 (4-hydroxy benzaldehyde), 4-이소프로필-3-메틸페놀 (사이멘-5-올) (4-isopropyl-3-methylphenol (Cymen-5-ol)), 5-아미노-1,3-비스(2-에틸헥실)-5-메틸-헥사하이드로피리미딘 (5-amino-1,3-bis(2-ethylhexyl)-5-methyl-hexahydropyrimidine), 5-브로모-5-니트로-1,3-디옥산 (5-bromo-5-nitro-1,3-dioxane), 5-클로로-2-메틸-3(2H)-이소티아졸리논 (5-chloro-2-methyl-3(2H)-isothiazolinone), 5-에틸-1-아자-3,7-디옥사바이사이클로 (3.3.0) 옥탄 (5-ethyl-1-aza-3,7-dioxabicyclo(3.3.0)octane), 알킬-(C8-C18)-디메틸-벤질암모늄 브로마이드 (alkyl-(C8-C18)-dimethyl-benzylammonium bromide), 알킬-(C8-C18)-디메틸-벤질-암모늄 클로라이드 (alkyl-(C8-C18)-dimethyl-benzyl-ammonium chloride), 알킬-(C8-C18)-디메틸-벤질-암모늄 사카리네이트 alkyl-(C8-C18)-dimethyl-benzyl-ammonium saccharinate, 아니스산 (anisic acid) 및 이것의 염들, 벤조산 (benzoic acid) 및 파라-하이드록시벤조산 (para-hydroxybenzoic acid), 그들의 에스터들 및 염들, 벤질 알코올 (benzyl alcohol), 벤질 벤조에이트 (benzyl benzoate), 벤질 헤미포르말 (benzyl hemiformal), 벤질옥시메탄올 (benzyloxymethanol), 벤질옥시메톡시-메탄올 헥사메틸렌테트라민(benzyloxymethoxy-methanol hexamethylenetetramine), 비스(2-피리딜티오)아연 1,1'-디옥사이드 (bis(2-pyridylthio)zinc 1,1'-dioxide), N,N'-(데칸-1,10-디일디피리딘-1-일-4-이리덴)-디옥탄-1-아민 디하이드로클로라이드 (옥테니딘 디하이드로클로라이드) (N,N'-(decane-1,10-diyldipyridin-1-yl-4-ylidene)-dioctan-1-amine dihydrochloride (octenidine dihydrochloride)), 브로모클로로펜 (bromochlorophene), 카프릴하이드록사믹산 (caprylhydroxamic acid), 카프릴로일 글리신(capryloyl glycin), 세틸 피리디움 클로라이드 (cetyl pyridium chloride), 키토산 (chitosan), 클로헥시딘 아세테이트 (chlorhexidine acetate), 클로헥시딘 글루코네이트 (chlorhexidine gluconate), 클로헥시딘 하이드로클로라이드 (chlorhexidine hydrochloride), 클로로부타놀륨 (chlorobutanolum), 신남산 (cinnamic acid) 및 이것의 염들, 신남 알코올 (cinnamic alcohol), 신남 알데하이드 (cinnamic aldehyde), 클림바졸 (climbazole), 디하이드라세틱산 (dehydracetic acid), 디아졸리딘유레아 (diazolidinylurea), DMDM 하이단토인 (DMDM hydantoin), 에틸렌 디아민 테트라 아세테이트 (ethylene diamine tetra acetate...