COMPOUNDS AND METHODSDisclosed are compounds having the formula (I): wherein R1, R2, R3, R4, R5, and R6 are as defined herein, and methods of making and using the same.A compound according to Formula I:H wherein:R1 is (CrC4)alkyl;R2 is hydrogen or halogen;R3 is hydrogen, halogen, (d-C4)alkyl, (Ci-C4)haloalkyl, (C3-C6)cycloalkyl, aryl, hydroxyl, hydroxy(Ci-C4)alkyl-, (Ci-C4)alkoxy, (CrC4)alkoxy(Ci-C4)alkyl-,(Ci-C4)haloalkoxy, (C3-C6)cycloalkyloxy, (Ci-C4)alkylthio-, amino, (Ci-C4)alkylamino, or ((Ci-C4)alkyl)((Ci-C4)alkyl)amino;R4 is hydrogen, halogen, (CrC8)alkyl, (Ci-C8)haloalkyl, (C3-C8)cycloalkyl, hydroxyl, hydroxy(CrC8)alkyl-, (CrC8)alkoxy, (C1-C4)alkoxy(C1-C8)alkyl-, (CrC8)haloalkoxy, (C3-C8)cycloalkyloxy, (CrC8)alkylthio-, (CrC8)haloalkylthio-, -S02(CrC4)alkyl, amino, -NHR7, or -NR7R8;R5 is hydrogen;or R4 and R5 taken together with atoms through which they are connected form a 5 or 6 membered ring, optionally containing one or two additional heteroatoms selected from N, O and S, which ring may be unsubstituted or substituted with one to three substituents independently selected from (Ci-C4)alkyl, (Ci-C4)haloalkyl,hydroxy(Ci-C4)alkyl-, oxo, hydroxyl, (Ci-C4)alkoxy, (Ci-C4)haloalkoxy, and(Ci-C4)alkylthio-;R6 is (Ci-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C3-C8)cycloalkyl, aryl, or heteroaryl, wherein any aryl or heteroaryl group is optionally substituted one to three times, independently, by halogen, (CrC6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl,(C3-C6)cycloalkyl, (C C4)haloalkyl, cyano, -CO(C C4)alkyl, -C02H, -C02R7, -CONH2, -CONHR7, -CONR7R8, H02C(C C2)alkyl-, R702C(C C2)alkyl-, -SR7, -S02(C C4)alkyl, -S02NH2, -S02NHR7, -S02NR7R8, nitro, amino, -NHR7, -NR7R8, amino(C C2)alkyl-, R7HN(Ci-C2)alkyl-, R7R8N(C C2)alkyl-, -NHCO(C C4)alkyl, -NHS02(Ci-C4)alkyl, oxo, hydroxyl, -OR7, hydroxy(C C2)alkyl-, R70(C C2)alkyl-, cyano(C C2)alkyl-, aryl, heteroaryl, or heteroaryl(Ci-C2)alkyl-, wherein any said aryl or heteroaryl is optionally substituted one to three times, independently, by halogen, (d-C6)alkyl, (C3-C6)cycloalkyl, (Ci-C4)haloalkyl, cyano, -CO(C C4)alkyl, -C02H, -C02R7, -CONH2, -CONHR7, -CONR7R8, -SR7, -S02(CrC4)alkyl, -S02NH2, -S02NHR7, -S02NR7R8, nitro, amino, -NHR7, -NR7R8, -NHCO(C C4)alkyl, -NHS02(Ci-C4)alkyl, oxo, hydroxyl, -OR7, hydroxy(C C2)alkyl-, or R70(Ci-C2)alkyl-;R7 is (CrC )alkyl, aryl, heterocycloalkyl, or heterocycloalkyl(Ci-C2)alkyl, wherein said (CrC4)alkyl is optionally substituted one to three times, independently, by halogen, hydroxyl, (CrC4)alkoxy, amino, (CrC4)alkylamino, ((C1-C4)alkyl)((C1-C4)alkyl)amino, -C02H, -C02(C C4)alkyl, -CONH2, -CONH(C C4)alkyl, or-CON((C1-C4)alkyl)((C1-C4)alkyl); and wherein any heterocycloalkyl is optionally substituted by (Ci-C )alkyl; andR8 is (CrC4)alkyl;or R7 and R8 taken together with the nitrogen to which they are attached represent a 5-7 membered heterocyclic ring, optionally containing an additional heteroatom selected from oxygen, nitrogen, and sulfur, wherein said ring is optionally substituted one or two times, independently, by halogen, (Ci-C )alkyl, (Ci-C )haloalkyl, amino,(Ci-C )alkylamino, ((Ci-C )alkyl)((Ci-C )alkyl)amino, hydroxyl, oxo, (Ci-C )alkoxy, or (C C4)alkoxy(Ci-C4)alkyl;or a salt thereof.
화합물 및 방법본 발명은 하기 화학식 I을 갖는 화합물, 및 그의 제조 및 사용 방법을 개시한다. <화학식 I> 상기 식에서, R1, R2, R3, R4, R5 및 R6은 본원에 정의된 바와 같다.하기 화학식 I에 따른 화합물 또는 그의 염.<화학식 I>상기 식에서,R1은 (C1-C4)알킬이고;R2는 수소 또는 할로겐이고;R3은 수소, 할로겐, (C1-C4)알킬, (C1-C4)할로알킬, (C3-C6)시클로알킬, 아릴, 히드록실, 히드록시(C1-C4)알킬-, (C1-C4)알콕시, (C1-C4)알콕시(C1-C4)알킬-, (C1-C4)할로알콕시, (C3-C6)시클로알킬옥시, (C1-C4)알킬티오-, 아미노, (C1-C4)알킬아미노 또는 ((C1-C4)알킬)((C1-C4)알킬)아미노이고;R4는 수소, 할로겐, (C1-C8)알킬, (C1-C8)할로알킬, (C3-C8)시클로알킬, 히드록실, 히드록시(C1-C8)알킬-, (C1-C8)알콕시, (C1-C4)알콕시(C1-C8)알킬-, (C1-C8)할로알콕시, (C3-C8)시클로알킬옥시, (C1-C8)알킬티오-, (C1-C8)할로알킬티오-, -SO2(C1-C4)알킬, 아미노, -NHR7 또는 -NR7R8이고;R5는 수소이거나;또는 R4 및 R5는 이들이 연결되어 있는 원자와 함께, N, O 및 S로부터 선택된 1 또는 2개의 추가 헤테로원자를 임의로 함유하는 5 또는 6원 고리를 형성하고, 여기서 고리는 비치환되거나 또는 (C1-C4)알킬, (C1-C4)할로알킬, 히드록시(C1-C4)알킬-, 옥소, 히드록실, (C1-C4)알콕시, (C1-C4)할로알콕시 및 (C1-C4)알킬티오-로부터 독립적으로 선택된 1 내지 3개의 치환기로 치환될 수 있고;R6은 (C1-C8)알킬, (C2-C8)알케닐, (C2-C8)알키닐, (C3-C8)시클로알킬, 아릴 또는 헤테로아릴이고, 여기서 임의의 아릴 또는 헤테로아릴 기는 할로겐, (C1-C6)알킬, (C2-C6)알케닐, (C2-C6)알키닐, (C3-C6)시클로알킬, (C1-C4)할로알킬, 시아노, -CO(C1-C4)알킬, -CO2H, -CO2R7, -CONH2, -CONHR7, -CONR7R8, HO2C(C1-C2)알킬-, R7O2C(C1-C2)알킬-, -SR7, -SO2(C1-C4)알킬, -SO2NH2, -SO2NHR7, -SO2NR7R8, 니트로, 아미노, -NHR7, -NR7R8, 아미노(C1-C2)알킬-, R7HN(C1-C2)알킬-, R7R8N(C1-C2)알킬-, -NHCO(C1-C4)알킬, -NHSO2(C1-C4)알킬, 옥소, 히드록실, -OR7, 히드록시(C1-C2)알킬-, R7O(C1-C2)알킬-, 시아노(C1-C2)알킬-, 아릴, 헤테로아릴 또는 헤테로아릴(C1-C2)알킬-에 의해 독립적으로 1 내지 3회 임의로 치환되고, 여기서 임의의 상기 아릴 또는 헤테로아릴은 할로겐, (C1-C6)알킬, (C3-C6)시클로알킬, (C1-C4)할로알킬, 시아노, -CO(C1-C4)알킬, -CO2H, -CO2R7, -CONH2, -CONHR7, -CONR7R8, -SR7, -SO2(C1-C4)알킬, -SO2NH2, -SO2NHR7, -SO2NR7R8, 니트로, 아미노, -NHR7, -NR7R8, -NHCO(C1-C4)알킬, -NHSO2(C1-C4)알킬, 옥소, 히드록실, -OR7, 히드록시(C1-C2)알킬- 또는 R7O(C1-C2)알킬-에 의해 독립적으로 1 내지 3회 임의로 치환되고;R7은 (C1-C4)알킬, 아릴, 헤테로시클로알킬 또는 헤테로시클로알킬(C1-C2)알킬이고, 여기서 상기 (C1-C4)알킬은 할로겐, 히드록실, (C1-C4)알콕시, 아미노, (C1-C4)알킬아미노, ((C1-C4)알킬)((C1-C4)알킬)아미노, -CO2H, -CO2(C1-C4)알킬, -CONH2, -CONH(C1-C4)알킬 또는 -CON((C1-C4)알킬)((C1-C4)알킬)에 의해 독립적으로 1 내지 3회 임의로 치환되고; 여기서 임의의 헤테로시클로알킬은 (C1-C4)알킬에 의해 임의로 치환되고;R8은 (C1-C4)알킬이거나;또는 R7 및 R8은 이들이 부착되어 있는 질소와 함께, 산소, 질소 및 황으로부터 선택된 추가의 헤테로원자를 임의로 함유하는 5 내지 7원 헤테로시클릭 고리를 나타내고, 여기서 상기 고리는 할로겐, (C1-C4)알킬, (C1-C4)할로알킬, 아미노, (C1-C4)알킬아미노, ((C1-C4)알킬)((C1-C4)알킬)아미노, 히드록실, 옥소, (C1-C4)알콕시 또는 (C1-C4)알콕시(C1-C4)알킬에 의해 독립적으로 1 또는 2회 임의로 치환된다.