THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOFThe invention provides a compound of formula: or a salt thereof, wherein the variables RAA, n, ring A, ring B, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and R9 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.A compound of formula(I)or a salt thereof; wherein, each is independently selected from the group consisting of F, CI, Br, I, -CN,-C(=0)ORA1, -S02RA1, -ORAI, -(Χ^-β-Ιδ membered carbocyclyl), -(Χ^Ηό-Π membered aryl), -(Χ^Ηδ-Π membered heteroaryl), and -R^, wherein said 3-15 membered carbocyclyl, 6-12 membered aryl, and 5-12 membered heteroaryl of RAA is optionally substituted with from 1 to 5 substitutents RB independently selected from the group consisting of F, CI, Br, I, C1-4 alkyl, C haloalkyl, amino, C1-4 alkylamino, di(C1-4alkyl)amino, and Ci-4(halo)alkoxy; RA1 is selected from the group consisting of hydrogen, C1- alkyl, C2-8 alkenyl, Ci- haloalkyl, C3-8 cycloalkyl, phenyl and benzyl; RA2 is selected from the group consisting of Ci-8 alkyl that is optionally substituted with one or more substituents selected from oxo (=0), fluoro, hydroxy, amino, C1-4 alkylamino and di(CMalkyl)amino; X1^ is selected from the group consisting of absent, -C(=0)-, and C alkylene; wherein any C alkylene, of is optionally substituted with 1 to 3 substituents selected from the group consisting of C1-4 alkyl, C1-4 haloalkyl, and phenyl that is optionally substituted with 1 to 5 substitutents selected from, F, CI, Br, I, -NH2, -OH, -CN, -N02, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4(halo)alkoxy, C1-4 alkylamino and CM dialkylamino;ring 'A' is a 5-12 membered heteroaryl, or a 3-15 membered heterocyclyl;Rla is H or CM alkyl;Rlb is H or CM alkyl;R2 is selected from the group consisting of H, F, CI, Br, I, -CN, C1-8 alkyl, C3-8 cycloalkyl, Cj.g haloalkyl and C1-8 alkoxy;R3, R4, and R5 are each independently selected from the group consisting of H, F, CI, Br, I, -CN, Ci- alkyl, C3-8 cycloalkyl, Ci-8 haloalkyl and C1-8 alkoxy;R6 is selected from the group consisting of H, C]-8 alkyl, C3-8 cycloalkyl, aryl, and aryl(C alkyl); and R7 is selected from the group consisting of C1-8 alkyl, 3-15 membered heterocyclyl, 5-12 membered heteroaryl, -C(0)N(Rc)2 and -C(=NCN)N(RC)2; or R6 and R7, together with the nitrogen to which they are attached, form a 3-15 membered heterocyclyl or 5-12 membered heteroaryl; wherein any C1- alkyl, C3-8 cycloalkyl, aryl, aralkyl, 3-15 membered heterocyclyl, and 5-12 membered heteroaryl is optionally substituted with one or more groups Rd that are independently selected from the group consisting of F, CI, Br, I, -NH2, -OH, -CN, -N02, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, Ci-4(halo)alkoxy, Ci-4 alkylamino and C1-4 dialkylamino; each Rc is independently selected from the group consisting of hydrogen, C1-8 alkyl, C3-8 cycloalkyl, phenyl and benzyl; and n is 0, 1, 2, 3, 4, 5, or 6.(Ix)or a salt thereof; wherein,each R^ is independently selected from the group consisting of F, CI, Br, I, -CN,-C(=0)ORA1, -S02RA1, -ORA1, -(X^MS-IS membered carbocyclyl), -(Χ^Μό- membered aryl), -(XRA)-(5-12 membered heteroaryl), and -R7^ , wherein said 3-15 membered carbocyclyl, 6-12 membered aryl, and 5-12 membered heteroaryl of RM is optionally substituted with from 1 to 5 substitutents Rb independently selected from the group consisting of F, CI, Br, I, C]-4 alkyl, C haloalkyl, amino, CM alkylamino, di(C1-4alkyl)amino, Ci_4(halo)alkoxy, and -C(0)N(Rc)2; RA1 is selected from the group consisting of hydrogen, C1-8 alkyl, C2-8 alkenyl, Ci-8 haloalkyl, C3-8 cycloalkyl, phenyl and benzyl; RA2 is selected from the group consisting of Cj- alkyl that is optionally substituted with one or more substituents selected from oxo (=0), fluoro, hydroxy, amino, C1-4 alkylamino and di(Ci-4alkyl)amino; X1^ is selected from the group consisting of absent, -C(=0)-, and C alkyl ene; wherein any C alkyl ene, of is optionally substituted with 1 to 3 substituents selected from the group consisting of C1-4 alkyl, C1-4 haloalkyl, and phenyl that is optionally substituted with 1 to 5 substitutents selected from, F, CI, Br, I, -NH2, -OH, -CN, -N02, CM alkyl, CM haloalkyl, CM alkoxy, C1-4(halo)alkoxy, C1-4 alkylamino and CM dialkylamino; ring 'A' is a 5-12 membered heteroaryl, or a 3-15 membered heterocyclyl;Ring B is a 5, 6, or 7 membered carbocyclyl or a 5, 6, or 7 membered heterocyclyl, which 5, 6, or 7 membered carbocyclyl and 5, 6, or 7 membered heterocyclyl is optionally substituted with one or more groups independently selected from CM alkyl, halo, and haloCM alkyl;Rlb is H or C alkyl;R3, R4, and R5 are each independently selected from the group consisting of H, F, CI, Br, I, -CN, Ci-8 alkyl, C3-8 cycloalkyl, Ci-8 haloalkyl and Ci-8 alkoxy; R6 is selected from the group consisting of H, C]-8 alkyl, C3- cycloalkyl, aryl, and aryl^ alkyl); and R7 is selected from the group consisting of C1-8 alkyl, 3-15 membered heterocyclyl, 5-12 membered heteroaryl, -C(0)N(Rc)2 and -C(=NCN)N(RC)2; or R6 and R7, together with the nitrogen to which they are attached, form a 3-15 membered heterocyclyl or 5-12 membered heteroaryl; wherein any C1-8 alkyl, C3-8 cycloalkyl, aryl, aralkyl, 3-15 membered heterocyclyl, and 5-12 membered heteroaryl is optionally substitute...
치료 화합물 및 그의 사용 방법본 발명은 하기 식의 화합물:  또는  또는 이의 염 (상기 변수RAA, n, 고리 A, 고리 B, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, 및 R9는 본 명세서에서 기재된 바와 같은 의미를 갖는다), 및 그와 같은 화합물을 함유하는 조성물 및 그와 같은 화합물 및 조성물을 사용하는 방법을 제공한다.식 (I)의 화합물 또는 이의 염:식 중,각각의 RAA는 F, Cl, Br, I, -CN, -C(=O)ORA1, -SO2RA1, -ORA1, -(XRA)-(3-15 원 카보사이클릴), -(XRA)-(6-12 원 아릴), -(XRA)-(5-12 원 헤테로아릴), 및 -RA2로 구성된 군으로부터 독립적으로 선택되고, 상기 RAA의 3-15 원 카보사이클릴, 6-12 원 아릴, 및 5-12 원 헤테로아릴은 F, Cl, Br, I, C1-4 알킬, C1-4 할로알킬, 아미노, C1-4 알킬아미노, 디(C1-4알킬)아미노, 및 C1-4(할로)알콕시로 구성된 군으로부터 독립적으로 선택된 1 내지 5개의 치환체 Rb로 임의로 치환되고; RA1 는 수소, C1-8 알킬, C2-8 알케닐, C1-8 할로알킬, C3-8 사이클로알킬, 페닐 및 벤질로 구성된 군으로부터 선택되고; RA2는 옥소 (=O), 플루오로, 하이드록시, 아미노, C1-4 알킬아미노 및 디(C1-4알킬)아미노로부터 선택된 1개 이상의 치환체로 임의로 치환된 C1-8 알킬로 구성된 군으로부터 선택되고; XRA는 부재, -C(=O)-, 및 C1-4 알킬렌으로 구성된 군으로부터 선택되고; 식 중, XRA의 임의의 C1-4 알킬렌은 C1-4 알킬, C1-4 할로알킬, 및 페닐로 구성된 군으로부터 선택된 1 내지 3개의 치환체로 임의로 치환되고, 상기 페닐은 F, Cl, Br, I, -NH2, -OH, -CN, -NO2, C1-4 알킬, C1-4 할로알킬, C1-4 알콕시, C1-4(할로)알콕시, C1-4 알킬아미노 및 C1-4 디알킬아미노로부터 선택된 1 내지 5개의 치환체로 임의로 치환되고;환 "A"는 5-12 원 헤테로아릴, 또는 3-15 원 헤테로사이클릴이고; R1a는 H 또는 C1-4 알킬이고; R1b는 H 또는 C1-4 알킬이고;R2 는 H, F, Cl, Br, I, -CN, C1-8 알킬, C3-8 사이클로알킬, C1-8 할로알킬 및 C1-8 알콕시로 구성된 군으로부터 선택되고; R3, R4, 및 R5각각은 H, F, Cl, Br, I, -CN, C1-8 알킬, C3-8 사이클로알킬, C1-8 할로알킬 및 C1-8 알콕시로 구성된 군으로부터 독립적으로 선택되고; R6 은 H, C1-8 알킬, C3-8 사이클로알킬, 아릴, 및 아릴(C1-4 알킬)로 구성된 군으로부터 선택되고; 그리고 R7은 C1-8 알킬, 3-15 원 헤테로사이클릴, 5-12 원 헤테로아릴, -C(O)N(Rc)2 및 -C(=NCN)N(Rc)2로 구성된 군으로부터 선택되거나; 또는 R6 및 R7 은, 이들이 부착된 질소와 함께, 3-15 원 헤테로사이클릴 또는 5-12 원 헤테로아릴을 형성하고; 식 중, 임의의 C1-8 알킬, C3-8 사이클로알킬, 아릴, 아르알킬, 3-15 원 헤테로사이클릴, 및 5-12 원 헤테로아릴은 F, Cl, Br, I, -NH2, -OH, -CN, -NO2, C1-4 알킬, C1-4 할로알킬, C1-4 알콕시, C1-4(할로)알콕시, C1-4 알킬아미노 및 C1-4 디알킬아미노로 구성된 군으로부터 독립적으로 선택된 1개 이상의 기들 Rd로 임의로 치환되고; 각각의 Rc는 수소, C1-8 알킬, C3-8 사이클로알킬, 페닐 및 벤질로 구성된 군으로부터 독립적으로 선택되고; 그리고n은 0, 1, 2, 3, 4, 5, 또는 6이다.