ISOQUINOLINE DERIVATIVEA compound represented by formula (I) or a pharmaceutically acceptable salt thereof has an effect of inhibiting CRTH2 and, therefore, is useful as a preventive or a remedy for allergic diseases such as asthma, atopic dermatitis and allergic rhinitis.A compound represented by formula (I):  wherein R1 represents a C1-6 alkyl group, a C2-6 alkenyl group, a C3-6 cycloalkyl group, a C3-6 cycloalkenyl group, an adamantyl group, an indanyl group, a tetrahydronaphthyl group, a tetrahydroindolyl group, a tetrahydropyranyl group, a morpholinyl group, a phenyl group, a naphthyl group, or an aromatic heterocyclic group, wherein the phenyl group, the naphthyl group, and the aromatic heterocyclic group may be substituted with 1 to 5 substituent(s) selected from the group consisting of a C1-6 alkyl group, a C2-6 alkenyl group, a C3-6 cycloalkyl group, a halogen atom, a C1-6 alkoxy group, a hydroxy group, a C1-6 alkylthio group, a C1-6 haloalkyl group, a C1-6 haloalkoxy group, a C1-6 haloalkylthio group, a cyano group, a nitro group, a guanidino group, a C1-6 alkylsulfonyl group, a carboxy group, a C2-7 alkoxycarbonyl group, a C2-7 alkanoyloxy group, a phenyl group, a benzoyl group, a phenoxy group, a pyrrolyl group, a thienyl group, an imidazolyl group, a thiadiazolyl group, a morpholino group, the formula: - NR5R6, the formula: -SO2NR7R8, the formula: -NR9SO2R10, the formula: -CONR11R12, and the formula: -NR13COR14, wherein R5, R6, R7, R8, R9, R10, R11, R12, R13, and R14 each independently represent a hydrogen atom or a C1-6 alkyl group; X represents an oxygen atom, a sulfur atom, the formula: -CH2-, the formula: -CO-, or the formula: -NR2-, wherein R2 represents a hydrogen atom or a C1-6 alkyl group; Y represents a single bond, the formula: -NR3CO-W-, the formula: -NR3CO-W-O-, the formula: - NR3CO2-W-, the formula: -NR3-W-, the formula: -NR3SO2-W-, the formula: -NR3CONR4-W-, the formula: -NR3CO-W-NR4SO2-, the formula: -SO2NR3-W-, the formula: -CH2-W-, the formula: -CONR3-W-, the formula: -CONR3-W-O-, the formula: -CH2-O-W-, the formula: - CH2NR3-W-, the formula: -CONR3-W-NR4CO-, the formula: -O-W-, or the formula: -O-W-O-, wherein R3 and R4 each independently represent a hydrogen atom or a C1-6 alkyl group, W is a single bond, a C1-6 alkylene group, a C2-6 alkylene group including a carbon atom that is also a member of a C3-6 cycloalkyl ring, a C2-6 alkenylene group, or a C3-6 cycloalkylene group (provided that, when Y is the formula: -CONR3-W-NR4CO- or the formula: -O-W-O-, W is not a single bond); Z represents a benzene ring, a pyrimidine ring, or a pyrazine ring; Ra represents a carboxy group, a carbamoyl group, a tetrazolyl group, or the formula: - CONHOH; Rb and Rc each independently represent a hydrogen atom, a halogen atom, or a C1-6 alkyl group; and Rd, Re, Rf and Rg each independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group (provided that the compound is not {1-[3-(butan-2-yloxy)benzy]-6,7-dimethoxyisoquinolin-4-yl}acetic acid, (1-([3-(butan-2-yl)phenyl]carbonyl)-6,7-dimethoxyisoquinolin-4-yl)acetic acid, (1-{[3-(butan-2-yloxy)phenyl]carbonyl}-6,7-dimethoxyisoquinolin-4-yl)acetic acid, 2-(6,7-dimethoxy-1-{[3-(propan-2-yloxy)phenyl]carbonyl}isoquinolin-4-yl)acetamide, (6,7-dimethoxy-1-{[3-(propan-2-yloxy)phenyl]carbonyl}isoquinolin-4-yl)acetic acid, 2-{6,7-dimethoxy-1-[(3-methoxyphenyl)carbonyl]isoquinolin-4-yl}acetamide, or {6,7-dimethoxy-1-[(3-methoxyphenyl)carbonyl] isoquinolin-4-yl}acetic acid); or a pharmaceutically acceptable salt thereof
이소퀴놀린 유도체하기 화학식 I로 표시되는 화합물 또는 그의 의약상 허용되는 염은 CRTH2의 저해 작용을 갖고, 천식, 아토피성 피부염, 알레르기성 비염 등의 알레르기성 질환의 예방제 또는 치료제로서 유용하다. <화학식 I>하기 화학식 I로 표시되는 화합물 또는 그의 의약상 허용되는 염. <화학식 I>(식 중, R1은 C1-6알킬기, C2-6알케닐기, C3-6시클로알킬기, C3-6시클로알케닐기, 아다만틸기, 인다닐기, 테트라히드로나프틸기, 테트라히드로인돌릴기, 테트라히드로피라닐기, 모르폴리닐기, 페닐기, 나프틸기 또는 방향족 복소환기를 나타내고, 상기 페닐기, 나프틸기 및 방향족 복소환기는 C1-6알킬기, C2-6알케닐기, C3-6시클로알킬기, 할로겐 원자, C1-6알콕시기, 히드록시기, C1-6알킬티오기, C1-6할로알킬기, C1-6할로알콕시기, C1-6할로알킬티오기, 시아노기, 니트로기, 구아니디노기, C1-6알킬술포닐기, 카르복시기, C2-7알콕시카르보닐기, C2-7알카노일옥시기, 페닐기, 벤조일기, 페녹시기, 피롤릴기, 티에닐기, 이미다졸릴기, 티아디아졸릴기, 모르폴리노기, 식 -NR5R6, 식 -SO2NR7R8, 식 -NR9SO2R10, 식 -CONR11R12 및 식 -NR13COR14로 이루어지는 군으로부터 선택되는 1 내지 5개의 치환기로 치환될 수도 있고, R5, R6, R7, R8, R9, R10, R11, R12, R13 및 R14는 각각 독립적으로 수소 원자 또는 C1-6알킬기를 나타내고, X는 산소 원자, 황 원자, 식 -CH2-, 식 -CO- 또는 식 -NR2-를 나타내고, R2는 수소 원자 또는 C1-6알킬기를 나타내고, Y는 단결합, 식 -NR3CO-W-, 식 -NR3CO-W-O-, 식 -NR3CO2-W-, 식 -NR3-W-, 식 -NR3SO2-W-, 식 -NR3CONR4-W-, 식 -NR3CO-W-NR4SO2-, 식 -SO2NR3-W-, 식 -CH2-W-, 식 -CONR3-W-, 식 -CONR3-W-O-, 식 -CH2-O-W-, 식 -CH2NR3-W-, 식 -CONR3-W-NR4CO-, 식 -O-W- 또는 식 -O-W-O-를 나타내고, R3 및 R4는 각각 독립적으로 수소 원자 또는 C1-6알킬기를 나타내고, W는 단결합, C1-6알킬렌기, C2-6알킬렌기의 임의의 1개의 탄소 원자가 환 구성 탄소 원자로서 C3-6시클로알킬환을 형성한 기, C2-6알케닐렌기 또는 C3-6시클로알킬렌기를 나타내고(단, Y가 식 -CONR3-W-NR4CO- 또는 식 -O-W-O-인 경우, W는 단결합이 아님), Z는 벤젠환, 피리미딘환 또는 피라진환을 나타내고, Ra는 카르복시기, 카르바모일기, 테트라졸릴기 또는 식 -CONHOH를 나타내고, Rb 및 Rc는 각각 독립적으로 수소 원자, 할로겐 원자 또는 C1-6알킬기를 나타내고, Rd, Re, Rf 및 Rg는 각각 독립적으로 수소 원자, 할로겐 원자, C1-6알킬기 또는 C1-6알콕시기를 나타냄(단, 화합물이 {1-[3-(부탄-2-일옥시)벤질]-6,7-디메톡시이소퀴놀린-4-일}아세트산, (1-{[3-(부탄-2-일)페닐]카르보닐}-6,7-디메톡시이소퀴놀린-4-일)아세트산, (1-{[3-(부탄-2-일옥시)페닐]카르보닐}-6,7-디메톡시이소퀴놀린-4-일)아세트산, 2-(6,7-디메톡시-1-{[3-(프로판-2-일옥시)페닐]카르보닐}이소퀴놀린-4-일)아세트아미드, (6,7-디메톡시-1-{[3-(프로판-2-일옥시)페닐]카르보닐}이소퀴놀린-4-일)아세트산, 2-{6,7-디메톡시-1-[(3-메톡시페닐)카르보닐]이소퀴놀린-4-일}아세트아미드, {6,7-디메톡시-1-[(3-메톡시페닐)카르보닐]이소퀴놀린-4-일}아세트산인 경우를 제외함))