Tetrahydrocarbazole derivatives and their pharmaceutical useThe present invention relates to novel compounds of formula (I) that are useful in the treatment of human papillomaviruses, and also to the methods for the making and use of such compounds.The compound of a following formula (i) and the acceptable salt of medicine, solvate and neurological progression biology:wherein:n is 0,1 or 2;x is nh, o or s (o) meach r is identical or different, and independently be selected from halogen, haloalkyl, alkyl, thiazolinyl, alkynyl, cycloalkyl, cycloalkenyl group ,-r 10cycloalkyl, ay ,-nhr 10ay, het ,-nhhet ,-nhr 10het ,-or 2,-oay ,-ohet ,-r 10or 2,-nr 2r 3,-nr 2ay ,-r 10nr 2r 3,-r 10nr 2ay ,-r 10c (o) r 2,-c (o) r 2,-co 2r 2,-r 10co 2r 2,-c (o) nr 2r 3,-c (o) ay ,-c (o) nr 2ay ,-c (o) het ,-c (o) nhr 10het ,-r 10c (o) nr 2r 3,-c (s) nr 2r 3,-r 10c (s) nr 2r 3,-r 10nhc (nh) nr 2r 3,-c (nh) nr 2r 3,-r 10c (nh) nr 2r 3,-s (o) 2nr 2r 3,-s (o) 2nr 2ay ,-r 10so 2nhcor 2,-r 10so 2nr 2r 3,-r 10so 2r 2,-s (o) mr 2, cyano group, nitro or azido-; each r 1identical or different, and independently be selected from halogen, haloalkyl, alkyl, thiazolinyl, alkynyl, cycloalkyl, cycloalkenyl group ,-r 10cycloalkyl, ay ,-nhr 10ay, het ,-nhhet ,-nhr 10het ,-or 2,-oay ,-ohet ,-r 10or 2,-nr 2r 3,-nr 2ay ,-r 10nr 2r 3,-r 10nr 2ay ,-r 10c (o) r 2,-c (o) r 2,-co 2r 2,-r 10co 2r 2,-c (o) nr 2r 3,-c (o) ay ,-c (o) nr 2ay ,-c (o) het ,-c (o) nhr 10het ,-r 10c (o) nr 2r 3,-c (s) nr 2r 3,-r 10c (s) nr 2r 3,-r 10nhc (nh) nr 2r 3,-c (nh) nr 2r 3,-r 10c (nh) nr 2r 3,-s (o) 2nr 2r 3,-s (o) 2nr 2ay ,-r 10so 2nhcor 2,-r 10so 2nr 2r 3,-r 10so 2r 2,-s (o) mr 2, cyano group, nitro or azido-; each m is 0,1 or 2 independently;each r 10identical or different, and independently be selected from alkylidene group, cycloalkylidene, alkenylene, inferior cycloalkenyl group and alkynylene; p and q independently are selected from 0,1,2,3,4 or 5 separately;each r 2and r 3identical or different, and independently be selected from h, alkyl, thiazolinyl, alkynyl, cycloalkyl, cycloalkenyl group ,-r 10cycloalkyl ,-r 10oh ,-r 10(or 10) wwith-r 10nr 4r 5w is 1-10;each r 4and r 5identical or different, and independently be selected from alkyl, cycloalkyl, thiazolinyl, cycloalkenyl group and alkynyl; ay represents aryl;het represents 5 yuan or 6 yuan of heterocyclic radicals or heteroaryl;the a ring is aryl or heteroaryl.
테트라하이드로카르바졸 유도체 및 이들의 약제학적 용도본 발명은 인간 파필로마바이러스의 치료에 유용한 신규한 화학식(I)의 화합물 및 이러한 화합물의 제조 방법 및 용도에 관한 것이다.  화학식(I)의 화합물, 이의 약제학적 허용 염, 용매화물, 및 생리적 작용성 유도체: [이미지] 상기 식에서, n은 0, 1, 또는 2이고; X는 NH, 0, 또는 S(O)m이며; 각 R은 동일하거나 상이하고, 독립적으로 할로겐, 할로알킬, 알킬, 알케닐, 알키닐, 시클로알킬, 시클로알케닐, -R10시클로알킬, Ay, -NHR10Ay, Het, -NHHet, -NHR10Het, -OR2, -OAy, -OHet, -R100R2, -NR2R3, -NR2Ay, -R10NR2R3, -R10NR2Ay, -R10C(O)R2, -C(O)R2, - C02R2, -R10C02R2, -C(O)NR2R3, -C(O)Ay, -C(O)NR2Ay, -C(O)Het, -C(O)NHR10Het, -R10C(O)NR2R3, -C(S)NR2R3, -R10C(S)NR2R3, -R10NHC(NH)NR2R3, -C(NH)NR2R3, -R10C(NH)NR2R3, -S(O)2NR2R3, -S(O)2NR2Ay, R10S02NHCOR2, -R10S02NR2R3, -R10S02R2, S(O)mR2, 시아노, 니트로, 또는 아지도로 구성된 군으로부터 선택되고; 각 R1은 동일하거나 상이하고, 독립적으로 할로겐, 할로알킬, 알킬, 알케닐, 알키닐, 시클로알킬, 시클로알케닐, -R10시클로알킬, Ay, -NHR10Ay, Het, -NHHet, -NHR10Het, -OR2, -OAy, -OHet, -R10OR2, -NR2R3, -NR2Ay, -R10NR2R3, -R10NR2Ay, -R10C(O)R2, -C(O)R2, -CO2R2, -R10C02R2, -C(O)NR2R3, -C(O)Ay, -C(O)NR2Ay, -C(O)Het, -C(O)NHR10Het, -R10C(O)NR2R3, -C(S)NR2R3, -R10C(S)NR2R3, -R10NHC(NH)NR2R3, -C(NH)NR2R3, -R10C(NH)NR2R3, -S(O)2NR2R3, -S(O)2NR2Ay, -R10SO2NHCOR2, -R10S02NR2R3, -R10S02R2, -S(O)mR2, 시아노, 니트로, 또는 아지도로 구성된 군으로부터 선택되며; 각 m은 독립적으로 0, 1, 또는 2이고; 각 R10은 동일하거나 상이하고, 독립적으로 알킬렌, 시클로알킬렌, 알케닐렌, 시클로알케닐렌, 및 알키닐렌으로부터 선택되며; p 및 q은 각각 독립적으로 0, 1, 2, 3, 4, 또는 5로부터 선택되고; R2 및 R3의 각각은 동일하거나 상이하고, 독립적으로 H, 알킬, 알케닐, 알키닐, 시클로알킬, 시클로알케닐, -R10시클로알킬, -R10OH, -R10(OR10)w, 및 -R10NR4R5로 구성된 군으로부터 선택되며; w는 1-10이고; R4 및 R5의 각각은 동일하거나 상이하고, 독립적으로 알킬, 시클로알킬, 알케닐, 시클로알케닐, 및 알키닐로 구성된 군으로부터 선택되며; Ay은 아릴 기를 나타내고; Het는 5- 또는 6-원 헤테로시클릴 또는 헤테로아릴 기를 나타내며; 고리 A는 아릴 또는 헤테로아릴이다.