TRIPLE QUADRUPOLE MASS SPECTROMETERS CONFIGURED TO DETECT MRM TRANSITIONS OF PESTICIDE RESIDUESThis disclosure provides quantitative, rapid, and reliable LCMS/MS methods for analyzing panels of pesticides and mycotoxins in various samples, including very hydrophobic and chlorinated compounds normally analyzed on a GCMS/MS system. The methods can be carried out using a single instrument and can detect and quantify levels of the pesticides and mycotoxins that are well below action limits specified by U.S. states (e.g., California) and other countries (e.g., Canada) for these compounds in cannabis products.A triple quadrupole mass spectrometer, comprising:(a) an electrospray ionization (esi) source, wherein the triple quadrupole mass spectrometer is configured to detect multiple reaction monitoring (mrm) parent-child ion pairs selected from the group consisting of mrm parent-child ion pairs in group a:890.5>145.0 (avermectin);890.5>567.2 (avermectin);890.5>305.1 (avermectin);184.0>49.0 (acephate);184.0>95.0 (acephate);402.2>343.1 (acequinocyl);402.2>189 (acequinocyl);208.0>116.0 (aldicarb);208.0>89.0 (aldicarb);343.0>272.0 (boscalid);316.9>263.9 (captan);316.9>235.9 (captan);318.9>265.9 (captan);318.9>237.9 (captan);409.0>59.1 (chlorfenapyr);407.0>59.1 (chlorfenapyr);424.0>59.1 (chlorfenapyr);426.0>59.1 (chlorfenapyr);349.9>321.9 (chlorpyrifos);317.2>121.0 (guaethrin i);317.2>107.0 (guaethrin i);317.2>149.0 (guaethrin i);361.2>149.0 (guaethrin ii);361.2>213.0 (guaethrin ii);363.0>306.9 (coumaphos);363.0>334.9 (coumaphos);363.0>226.9 (coumaphos);453.1>193.0 (cyfluthrin);451.1>127.0 (cyfluthrin);451.1>191.0 (cyfluthrin);435.1>193.1 (cypermethrin);435.1>127.0 (cypermethrin);433.1>127.0 (cypermethrin);161.1>44.0 (butyrylhydrazine);161.1>45.0 (butyrylhydrazine);165.1>147.0 (butyrhydrazide-d)4)；220.9>127.0 (dichlorvos);388.1>301.0 (dimethomorph);388.1>273.0 (dimethomorph);394.2>359.1 (ifenprox);302.1>55.0 (fenhexamid);302.1>97.0 (fenhexamid);302.1>256.0 (fenoxycarb);422.2>138.0 (fenpyroximate);435.0>250.0 (fipronil);435.0>330.0 (fipronil);247.1>126.0 (fludioxonil);247.1>180.0 (fludioxonil);297.0>41.0 (imazalil);260.2>213 (imidacloprid-d)4)；331.0>163.0 (jasminum i);375.2>163.0 (jasminum ii);375.2>213.0 (jasminum ii);331.0>285.0 (malathion);280.2>248.1 (metalaxyl);242.0>127.0 (meta-phos);242.0>109.0 (meta-phos);225.0>127.0 (fast phosphorus removal);225.0>109.0 (methamphetamine);298.0>70.0 (myclobutanil d)9)；276.2>98.0 (n-octylbicycloheptenedicarboxyimide (mgk-264);380.8>127.0 (phosphorus dibromide);382.8>127.0 (phosphorus dibromide);380.8>109.0 (phosphorus dibromide);318.0>133.0 (phosmet);301.2>123 (prallethrin);344.1>69.0 (propiconazole);344.1>161.0 (propiconazole);329.2>143.0 (pyrethrin i);373.2>143.0 (pyrethrin ii);378.0>160.0 (pyridaben-d)13)；748.5>98.0 (spinetoram);748.5>142.0 (spinetoram);746.5>98.0 (spinosyn d);746.5>142.0 (spinosyn d);374.2>216.0 (spirotetramat);296.0>215.0 (thiamethoxam-d)4)；343.1>151.0 (thiophanate-methyl); and343.1>268.0 (thiophanate-methyl); or(b) an atmospheric chemical ionization (apci) source, wherein the triple quadrupole mass spectrometer is configured to detect mrm parent-child ion pairs selected from the group consisting of mrm parent-child ion pairs in group b:439.8>35.1 (chlordane);441.8>35.1 (chlordane);275.8>35.1(pcnb)；273.8>35.1(pcnb)；275.8>201.9(pcnb)；216.8>35.0 (chlorazol-ethyl);218.8>35.0 (chlorazol-ethyl);346.9>79.0 (chlorfenapyr); and348.9>81.0 (chlorfenapyr); or(c) the esi source and the apci source.
살충제 잔류물의 MRFM 전이를 검출하도록 구성된 삼중 사중극자 질량 분석계본 개시는 GCMS/MS 시스템에서 정상적으로 분석되는 매우 소수성이고 염소화된 화합물을 포함하여 다양한 샘플 중의 살충제의 패널 및 미코톡신을 분석하기 위한 정량적이고 신속하며 신뢰할 수 있는 LC-MS/MS 방법을 제공한다. 상기 방법은 단일 기기를 사용하여 수행될 수 있고, 대마초 제품 중 화합물에 대해 미국의 주(예를 들어, 캘리포니아) 및 다른 국가(예를 들어, 캐나다)에 의해 지정된 작용 한계보다 훨씬 아래인 살충제 및 미코톡신의 수준을 검출 및 정량할 수 있다.다음을 포함하는 삼중 사중극자 질량 분석계:(a) 전기분무 이온화(electrospray ionization, ESI) 공급원, 여기서 삼중 사중극자 질량 분석계는 그룹 A의 MRM 전이로 이루어진 군으로부터 선택된 다중 반응 모니터링(Multiple Reaction Monitoring, MRM) 전이를 검출하도록 구성됨:890.5 > 145.0 (아바멕틴);890.5 > 567.2 (아바멕틴);890.5 > 305.1 (아바멕틴);184.0 > 49.0 (아세페이트);184.0 > 95.0 (아세페이트);402.2 > 343.1 (아세퀴노실);402.2 > 189 (아세퀴노실);208.0 > 116.0 (알디카르브);208.0 > 89.0 (알디카르브);343.0 > 272.0 (보스칼리드);316.9 > 263.9 (캡탄);316.9 > 235.9 (캡탄);318.9 > 265.9 (캡탄);318.9 > 237.9 (캡탄);409.0 > 59.1 (클로르페나피르);407.0 > 59.1 (클로르페나피르);424.0 > 59.1 (클로르페나피르);426.0 > 59.1 (클로르페나피르);349.9 > 321.9 (클로르피리포스);317.2 > 121.0 (시네린-I);317.2 > 107.0 (시네린-I);317.2 > 149.0 (시네린-I);361.2 > 149.0 (시네린-II);361.2 > 213.0 (시네린-II);363.0 > 306.9 (쿠마포스);363.0 > 334.9 (쿠마포스);363.0 > 226.9 (쿠마포스);453.1 > 193.0 (시플루트린);451.1 > 127.0 (시플루트린);451.1 > 191.0 (시플루트린);435.1 > 193.1 (시페르메트린);435.1 > 127.0 (시페르메트린);433.1 > 127.0 (시페르메트린);161.1 > 44.0 (다미노지드);161.1 > 45.0 (다미노지드);165.1 > 147.0 (다미노지드-D4);220.9 > 127.0 (디클로르보스);388.1 > 301.0 (디메토모르프);388.1 > 273.0 (디메토모르프);394.2 > 359.1 (에토펜프록스);302.1 > 55.0 (펜헥사미드);302.1 > 97.0 (펜헥사미드);302.1 > 256.0 (페녹시카르브);422.2 > 138.0 (펜피록시메이트);435.0 > 250.0 (피프로닐);435.0 > 330.0 (피프로닐);247.1 > 126.0 (플루디옥소닐);247.1 > 180.0 (플루디옥소닐);297.0 > 41.0 (이마자릴);260.2 > 213 (이미다클로프리드-D4);331.0 > 163.0 (자스몰린 I);375.2 > 163.0 (자스몰린 II);375.2 > 213.0 (자스몰린 II);331.0 > 285.0 (말라티온);280.2 > 248.1 (메탈락실);242.0 > 127.0 (메빈포스);242.0 > 109.0 (메빈포스);225.0 > 127.0 (메빈포스);225.0 > 109.0 (메빈포스);298.0 > 70.0 (미클로부타닐 D9);276.2 > 98.0 (n-옥틸 비사이클로헵텐 디카르복스이미드 (MGK-264);380.8 > 127.0 (날레드);382.8 > 127.0 (날레드);380.8 > 109.0 (날레드);318.0 > 133.0 (포스메트);301.2 > 123 (프랄레트린);344.1 > 69.0 (프로피코나졸);344.1 > 161.0 (프로피코나졸);329.2 > 143.0 (피레트린-I);373.2 > 143.0 (피레트린-II);378.0 > 160.0 (피리다벤-D13);748.5 > 98.0 (스피네토람);748.5 > 142.0 (스피네토람);746.5 > 98.0 (스피노신 D);746.5 > 142.0 (스피노신 D);374.2 > 216.0 (스피로테트라마트);296.0 > 215.0 (티아메톡삼-D4);343.1 > 151.0 (티오파네이트 메틸); 및343.1 > 268.0 (티오파네이트 메틸); 또는(b) 대기 화학 이온화(atmospheric chemical ionization, APCI) 공급원, 여기서 삼중 사중극자 질량 분석계는 그룹 B의 MRM 전이로 이루어진 군으로부터 선택된 MRM 전이를 검출하도록 구성됨:439.8 > 35.1 (클로르단);441.8 > 35.1 (클로르단);275.8 > 35.1 (PCNB);273.8 > 35.1 (PCNB);275.8 > 201.9 (PCNB);216.8 > 35.0 (에트리디아졸);218.8 > 35.0 (에트리디아졸);346.9 > 79.0 (클로르페나피르); 및348.9 > 81.0 (클로르페나피르); 또는(c) ESI 공급원 및 APCI 공급원.