Inhibitors of semicarabazide - sensitive amine oxidaseCompounds of formula (I) are inhibitors of Semicarbazide-sensitive amine oxidase wherein R, A, X and R are as defined in the claims.The compound of formula (i):perhaps its pharmacologically acceptable salt or n-oxide compound,whereinr 1be phenyl or 6 yuan of heteroaryls, it optionally is selected from one or more following substituting group and is replaced: halogen, cyano group, c 1-4-alkyl, halo-c 1-4-alkyl, c 1-4alkoxy-c 1-4alkyl, hydroxyl-c 1-4-alkyl, cyano group-c 1-4-alkyl, amino-c 1-4-alkyl, c 1-4-alkylamino-c 1-4-alkyl, two (c 1-4-alkyl) amino-c 1-4-alkyl ,-nr 4ar 4b,-nr 6c (o) or 5,-nr 6c (o) r 5,-nr 6c (o) nr 4ar 4b,-c (o) nr 4ar 4b,-c (o) r 5,-c (o) or 5and-nr 6s (o) 2r 5; a is key;r 2be-b-q-[r 3] nor-b-r 3, n=1,2,3 or 4 wherein;b is key, o, nr 4,-c (o)-or c 1-3-alkylidene group; q is saturated or the undersaturated monocycle 3-7 unit's heterocycle of part or c 3-7-cycloalkyl ring; work as r 2be-b-q-[r 3] nthe time, r 3be selected from hydrogen, halogen, cyano group, amino, hydroxyl, oxo, c 1-4-alkyl, halo-c 1-4-alkyl, c 1-4-alkoxyl group, c 1-4alkoxy-c 1-4alkyl, hydroxyl-c 1-4-alkyl, cyano group-c 1-4-alkyl, amino-c 1-4-alkyl, c 1-4-alkylamino-c 1-4-alkyl, two (c 1-4-alkyl) amino-c 1-4-alkyl ,-nr 4ar 4b,-nr 6c (o) or 5,-nr 6c (o) r 5,-nr 6c (o) nr 4ar 4b,-c (o) nr 4ar 4b,-c (o) r 5,-c (o) or 5,-nr 6s (o) 2r 5,-s (o) 2r 5, phenyl-c 1-4-alkyl and heteroaryl-c 1-4-alkyl, and wherein arbitrarily phenyl or heteroaryl residue optionally be selected from one or more following substituting group and replaced: halogen, cyano group, c 1-4-alkyl, halo-c 1-4-alkyl, c 1-4-alkoxyl group, c 1-4alkoxy-c 1-4alkyl, hydroxyl-c 1-4-alkyl, cyano group-c 1-4-alkyl, amino-c 1-4-alkyl, c 1-4-alkylamino-c 1-4-alkyl, two (c 1-4-alkyl) amino-c 1-4-alkyl ,-nr 4ar 4b,-nr 6c (o) or 5,-nr 6c (o) r 5,-nr 6c (o) nr 4ar 4b,-c (o) nr 4ar 4b,-c (o) r 5,-c (o) or 5,-nr 6s (o) 2r 5; work as r 2be-b-r 3the time, r 3be selected from amino, c 1-4-alkoxyl group, c 1-4-alkoxy-c 1-4-alkyl, hydroxyl-c 1-4-alkyl, cyano group-c 1-4-alkyl, amino-c 1-4-alkyl, c 1-4-alkylamino-c 1-4-alkyl, two (c 1-4-alkyl) amino-c 1-4-alkyl ,-nr 4ar 4b,-nr 6c (o) or 5,-nr 6c (o) r 5,-nr 6c (o) nr 4ar 4b,-c (o) nr 4a1r 4b,-c (o) r 5,-nr 6s (o) 2r 5, phenyl-c 1-4-alkyl and heteroaryl-c 1-4-alkyl, and wherein arbitrarily phenyl or heteroaryl residue optionally be selected from one or more following substituting group and replaced: halogen, cyano group, c 1-4-alkyl, halo-c 1-4-alkyl, c 1-4-alkoxyl group, c 1-4alkoxy-c 1-4alkyl, hydroxyl-c 1-4-alkyl, cyano group-c 1-4-alkyl, amino-c 1-4-alkyl, c 1-4-alkylamino-c 1-4-alkyl, two (c 1-4-alkyl) amino-c 1-4-alkyl ,-nr 4ar 4b,-nr 6c (o) or 5,-nr 6c (o) r 5,-nr 6c (o) nr 4ar 4b,-c (o) nr 4ar 4b,-c (o) r 5,-c (o) or 5,-nr 6s (o) 2r 5, prerequisite is to work as r 2be-b-r 3and b is key and r 3-c (o) r 5the time, r 5not hydrogen; r 4a, r 4band r 5be selected from independently of one another hydrogen, c 1-4-alkyl, hydroxyl-c 1-4-alkyl, halo-c 1-4-alkyl, cyano group-c 1-4-alkyl, amino-c 1-4-alkyl, c 1-4-alkylamino-c 1-4-alkyl, two (c 1-4-alkyl)-amino-c 1-4-alkyl or c 1-4alkoxy-c 1-4alkyl; perhaps r 4aand r 4bform amino piperazinyl, morpholinyl or the homopiperidinyl replaced as piperidyl, piperazinyl, n-of ring together with the nitrogen connected with them; r 4a1be selected from c 1-4-alkyl, hydroxyl-c 1-4-alkyl, halo-c 1-4-alkyl, cyano group-c 1-4-alkyl, amino-c 1-4-alkyl, c 1-4-alkylamino-c 1-4-alkyl, two (c 1-4-alkyl) amino-c 1-4-alkyl or c 1-4alkoxy-c 1-4alkyl; perhaps r 4a1and r 4bform amino piperazinyl, morpholinyl or the homopiperidinyl replaced as piperidyl, piperazinyl, n-of ring together with the nitrogen connected with them; r 6hydrogen or c 1-4-alkyl; and x is selected from the group of formula (1-16), wherein is marked with key and the r of * 1a-is connected, the key that is marked with * * and-r 2be connected: wherein y be selected from hydrogen, hydroxyl, amino ,-nhr 6,-och 3; z is selected from hydrogen, fluorine, hydroxyl, c 1-4-alkoxyl group, halo-c 1-4-alkyl, conh 2, cyano group, so 2nh 2, amino ,-nhr 6; w is selected from h, c 1-4-alkyl, halo-c 1-4-alkyl.
세미카르바지드-민감성 아민 옥시다제의 억제제화학식(I)의 화합물은 세미카르바지드-민감성 아민 옥시다제의 억제제이다:  식 중에서, R1, A, X 및 R2는 청구항에 정의된 바와 같다.하기 화학식(I)의 화합물 또는 그의 약학적으로 허용되는 염, 또는 N-옥사이드:[이미지]식 중에서,R1은 할로겐, 시아노, C1-4-알킬, 할로-C1-4-알킬, C1-4알콕시-C1-4알킬, 히드록시-C1-4-알킬, 시아노-C1-4-알킬, 아미노-C1-4-알킬, C1-4-알킬아미노-C1-4-알킬, 디(C1-4-알킬)아미노-C1-4-알킬, -NR4AR4B, -NR6C(0)OR5, -NR6C(0)R5, -NR6C(0)NR4AR4B, -C(0)NR4AR4B, -C(0)R5, -C(0)OR5, 및 -NR6S(0)2R5로부터 선택된 하나 이상의 치환기에 의해 경우에 따라 치환된 페닐 또는 6-원 헤테로아릴이며; A는 결합이며;R2는 -B-Q-[R3]n 또는 -B-R3이며;n = 1, 2, 3, 또는 4이며; B는 결합, O, NR4, -C(O)- 또는 C1-3-알킬렌이며;Q는 포화 또는 부분적으로 불포화된 모노시클릭 3-7원 헤테로시클릭 또는 C3-7-시클로알킬 고리이며; R2가 -B-Q-[R3]n이면, R3은 수소, 할로겐, 시아노, 아미노, 히드록실, 옥소, C1-4-알킬, 할로-C1-4-알킬, C1-4-알콕시, C1-4알콕시-C1-4알킬, 히드록시-C1-4-알킬, 시아노-C1-4-알킬, 아미노-C1-4-알킬, C1-4-알킬아미노-C1-4-알킬, 디(C1-4-알킬)아미노-C1-4-알킬, -NR4AR4B, -NR6C(0)OR5, -NR6C(0)R5, -NR6C(0)NR4AR4B, -C(0)NR4AR4B, -C(0)R5, -C(0)OR5, -NR6S(0)2R5, -S(0)2R5, 페닐-C1-4-알킬 및 헤테로아릴-C1-4-알킬로부터 선택되고, 페닐 또는 헤테로아릴 잔기는 할로겐, 시아노, C1-4-알킬, 할로-C1-4-알킬, C1-4-알콕시, C1-4알콕시-C1-4알킬, 히드록시-C1-4-알킬, 시아노-C1-4-알킬, 아미노-C1-4-알킬, C1-4-알킬아미노-C1-4-알킬, 디(C1-4-알킬)아미노-C1-4-알킬, -NR4AR4B, -NR6C(0)OR5, -NR6C(0)R5, -NR6C(0)NR4AR4B, -C(0)NR4AR4B, -C(0)R5, -C(0)OR5, -NR6S(0)2R5로부터 선택된 하나 이상의 치환기에 의해 경우에 따라 치환되며; R2가 -B-R3이면, R3은 아미노, C1-4-알콕시, C1-4알콕시-C1-4알킬, 히드록시-C1-4-알킬, 시아노-C1-4-알킬, 아미노-C1-4-알킬, C1-4-알킬아미노-C1-4-알킬, 디(C1-4-알킬)아미노-C1-4-알킬, -NR4AR4B, -NR6C(0)OR5, -NR6C(0)R5, -NR6C(0)NR4AR4B, -C(0)NR4A1R4B, -C(0)R5, -NR6S(0)2R5, 페닐-C1-4-알킬 및 헤테로아릴-C1-4-알킬로부터 선택되고, 페닐 또는 헤테로아릴 잔기는 할로겐, 시아노, C1-4-알킬, 할로-C1-4-알킬, C1-4-알콕시, C1-4알콕시-C1-4알킬, 히드록시-C1-4-알킬, 시아노-C1-4-알킬, 아미노-C1-4-알킬, C1-4-알킬아미노-C1-4-알킬, 디(C1-4-알킬)아미노-C1-4-알킬, -NR4AR4B, -NR6C(0)OR5, -NR6C(0)R5, -NR6C(0)NR4A1R4B, -C(0)NR4AR4B, -C(0)R5, -C(0)OR5, -NR6S(0)2R5로부터 선택된 하나 이상의 치환기에 의해 경우에 따라 치환되며, 단 R2가 -B-R3이고, B가 결합이며 R3이 -C(0)R5이면, R5는 수소가 아니며;R4A, R4B 및 R5는 각각 독립적으로 수소, C1-4-알킬, 히드록시-C1-4-알킬, 할로-C1-4-알킬, 시아노-C1-4-알킬, 아미노-C1-4-알킬, C1-4-알킬아미노-C1-4-알킬, 디(C1-4-알킬)아미노-C1-4-알킬 또는 C1-4알콕시-C1-4알킬로부터 선택되거나; 또는 R4A 및 R4B는 이들이 부착된 질소와 합쳐져서 피페리디닐, 피페라지닐, N-치환된 피페라지닐, 모르폴리닐 또는 호모피페리디닐기와 같은 시클릭 아미노기를 형성하고; R4A1은 C1-4-알킬, 히드록시-C1-4-알킬, 할로-C1-4-알킬, 시아노-C1-4-알킬, 아미노-C1-4-알킬, C1-4-알킬아미노-C1-4-알킬, 디(C1-4-알킬)아미노-C1-4-알킬 또는 C1-4알콕시-C1-4알킬로부터 선택되거나; 또는 R4A1 및 R4B는 이들이 부착된 질소와 합쳐져서 피페리디닐, 피페라지닐, N-치환된 피페라지닐, 모르폴리닐 또는 호모피페리디닐기와 같은 시클릭 아미노기를 형성하고; R6은 수소 또는 C1-4-알킬이며; X는 하기 화학식(1-16)의 라디칼로부터 선택되고, 이때 * 표시된 결합은 R1A-에 부착되고, ** 표시된 결합은 -R2에 부착되며: [이미지]식 중에서, Y는 수소, 히드록실, 아미노, -NHR6, -OCH3으로부터 선택되며; Z는 수소, 플루오르, 히드록실, C1-4-알콕시, 할로-C1-4-알킬, CONH2, 시아노, SO2NH2, 아미노, -NHR6으로부터 선택되고;W는 H, C1-4알킬, 할로-C1-4-알킬로부터 선택됨.