FLUORESCENT POLYMERIC COATING FILM FOR MEDICAL DEVICESA group of fluorescent polymeric coating films visible in near-infrared light for coating a medical device, and a method for preparing such NIR visible polymeric coating films.A fluorescent polymeric coating film visible in near-infrared light for coating a medical device, said coating film being a single layer or multiple layers of hydrophobic polymer, and at least one polymeric layer comprising a fluorescent dye and a counterion, said fluorescent dye being represented by Formula I wherein—: R8 and R9 are the same or different and independently selected from a group consisting of—: an hydrogen, ora group chosen from a (C1-C20)alkyl, a cyclo(C3-C20)alkyl, a (C2-C20)alkenyl, a (C2-C20)alkynyl, a heterocyclic group, a cyclo(C3-C20)alkenyl, a heterocyclo(C2-C20)alkenyl, an aryl, a heteroaryl, a hetero(C1-C20)alkyl, a (C1-C20)alkylaryl, or a (C1 C20)alkylheteroaryl, said group being unsubstituted or substituted by one or two substituents chosen from a (C1-C5) alkyl, an aryl, or —COOR11, R11 being a (C1-C20) alkyl, ora group of formula E-R10, wherein E is chosen from —O—, —S—, —Se—, —NH—, —CH2—; R10 is chosen from a (C1-C20)alkyl, a cyclo(C3-C20)alkyl, a (C2-C20)alkenyl, a (C2-C20)alkynyl, a heterocyclic group, a cyclo(C3-C20)alkenyl, a heterocyclo(C2-C20)alkenyl, an aryl, a heteroaryl, a hetero(C1-C20)alkyl, a (C1-C20)alkylaryl, a (C1-C20)alkylheteroaryl, R10 being unsubstituted or substituted by one to three substituents chosen from a (C1-C5) alkyl, an aryl, or —COOR11, R11 being a (C1-C20) alkylA1 is and A2 is or A1 is and A2 is wherein: R2 and R4 are independently selected from the group consisting of hydrogen, halogen, (C1-C10)alkyl, —OR5, —NR5R6, —NO2, —CF3, —CN, —SR5, —N3, —C(═O)R5, —OC(═)OR5, —C(═O)NR5R6, —NR5C(═O)R6, wherein R5 and R6 are independently selected from hydrogen, unsubstituted (C1-C10)alkyl, unsubstituted (C2-C10)alkenyl, unsubstituted (C2-C10)alkynyl, cyclo(C3-C10)alkyl, heterocyclic group, cyclo(C3-C10)alkenyl, heterocyclo(C2-C10)alkenyl, aryl, heteroaryl, aryl(C1-C10)alkyl, hetero(C1-C10)alkyl, (C1-C10)alkylaryl, (C1-C10)alkylheteroaryl;R1 and R3 are independently selected from the group consisting of a (C1-C20)alkyl eventually substituted by a hydrophobic group, a cyclo(C3-C20)alkyl eventually substituted by a hydrophobic group, a (C2-C20)alkenyl eventually substituted by a hydrophobic group, a (C2-C20)alkynyl, a heterocyclic group eventually substituted by a hydrophobic group, a cyclo(C3-C20)alkenyl eventually substituted by a hydrophobic group, a heterocyclo(C2-C20)alkenyl eventually substituted by a hydrophobic group, an aryl eventually substituted by a hydrophobic group, a heteroaryl eventually substituted by a hydrophobic group, a hetero(C1-C20)alkyl eventually substituted by a hydrophobic group, a (C1-C20)alkylaryl eventually substituted by a hydrophobic group, a (C1-C20)alkylheteroaryl eventually substituted by a hydrophobic group, said hydrophobic group being selected from methyl, ethyl, methoxy, ethyloxy;said hydrophobic polymer is chosen from poly(methyl methacrylate), poly(ethyl methacrylate), poly(propyl methacrylate), poly(butyl methacrylate), poly(methyl methacrylate-co-methacrylic acid), poly(lactide-co-glycolide), polylactic acid, polyglycolic acid, polycaprolacton, cellulose triacetate, nitrocellulose, polydimethylsiloxane, poly(ethylene terephthalate), polycarbonate, polyethylene, ethylene vinyl acetate copolymer, polyurethane, polystyrene, and copolymers thereof with poly(ethylene glycol).
의료 장비용 형광 폴리머 코팅 필름의료기기 코팅용 근적외선에서 가시광선 형광성 고분자 코팅막 군 및 이러한 근적외선 가시광선 고분자 코팅막의 제조방법.근적외선에서 볼 수 있는 의료 기기 코팅용 형광 고분자 코팅 필름으로서, 상기 코팅 필름은 소수성 고분자의 단층 또는 다층이며, 형광 염료와 반대 이온을 포함하는 적어도 하나의 고분자 층이며, 상기 형광 염료는 화학식 I에서, R8 및 R9는 동일하거나 상이하고 다음으로 이루어진 군으로부터 독립적으로 선택된다: 수소, 또는 (C1-C20)알킬, 시클로(C3-C20)알킬, 및 ( C2-C20)알케닐, (C2-C20)알키닐, 헤테로고리기, 시클로(C3-C20)알케닐, 헤테로시클로(C2-C20)알케닐, 아릴, 헤테로아릴, 헤테로(C1-C20)알킬 , (C1-C20)알킬아릴, 또는 (C1-C20)알킬헤테로아릴이고, 상기 기는 (C1-C5) 알킬, 아릴 또는 -COOR11에서 선택되는 1개 또는 2개의 치환기로 치환되거나 비치환되고, R11은 (C1 -C20) 알킬 또는 화학식 E-R10의 기(여기서, E는 -O-, -S-, -Se-, -NH-, -CH2-로부터 선택되며,); R10은 (C1-C20)알킬, 사이클로(C3-C20)알킬, (C2-C20)알케닐, (C2-C20)알키닐, 헤테로사이클릭 기, 사이클로(C3-C20)알케닐, 헤테로시클로(C2-C20)알케닐, 아릴, 헤테로아릴, 헤테로(C1-C20)알킬, (C1-C20)알킬아릴, (C1-C20)알킬헤테로아릴, R10은 비치환되거나 1 내지 3개의 치환기로 치환되며, (C1-C5) 알킬, 아릴, 또는 -COOR11로부터 선택되고, R11은 (C1-C20) 알킬이고, A2는 이거나, A1은 이고, A2는 이고, 여기서: R2 및 R4는 수소로 이루어진 군으로부터 독립적으로 선택되며, 할로겐, (C1-C10)알킬, -OR5, -NR5R6, -NO2, -CF3, -CN, -SR5, -N3, -C(=O)R5, -OC(=)OR5, -C(=) O)NR5R6, -NR5C(=O)R6, 여기서 R5 및 R6은 수소, 비치환된 (C1-C10)알킬, 비치환된 (C2-C10)알케닐, 비치환된 (C2-C10)알키닐, 시클로(C3- C10)알킬, 헤테로고리기, 시클로(C3-C10)알케닐, 헤테로시클로(C2-C10)알케닐, 아릴, 헤테로아릴, 아릴(C1-C10)알킬, 헤테로(C1-C10)알킬, (C1-C10)알킬아릴, (C1-C10)알킬헤테로아릴; R1 및 R3은 i 최종적으로 소수성기로 치환되는 (C1-C20)알킬, 소수성기로 최종적으로 치환되는 시클로(C3-C20)알킬, 소수성기로 최종적으로 치환되는 (C2-C20)알케닐로 이루어진 군으로부터 독립적으로 선택되고, (C2-C20)알키닐, 최종적으로 소수성기로 치환되는 헤테로고리기, 최종적으로 소수성기로 치환되는 시클로(C3-C20)알케닐, 소수성기로 최종적으로 치환되는 헤테로시클로(C2-C20)알케닐, 아릴 소수성기로 최종 치환, 소수성기로 최종 치환된 헤테로아릴, 소수성기로 최종 치환된 헤테로(C1-C20)알킬, 소수성기로 최종 치환된 (C1-C20)알킬아릴, (C1-C20) ) 소수성 기로 최종적으로 치환된 알킬헤테로아릴(상기 소수성 기는 메틸, 에틸, 메톡시, 에틸옥시로부터 선택되며,); 상기 소수성 중합체는 폴리(메틸 메타크릴레이트), 폴리(에틸 메타크릴레이트), 폴리(프로필 메타크릴레이트), 폴리(부틸 메타크릴레이트), 폴리(메틸 메타크릴레이트-co-메타크릴산), 폴리(락티드-코-글리콜리드), 폴리락트산, 폴리글리콜산, 폴리카프로락톤, 셀룰로오스 트리아세테이트, 니트로셀룰로오스, 폴리디메틸실록산, 폴리(에틸렌 테레프탈레이트), 폴리카보네이트, 폴리에틸렌 , 에틸렌 비닐 아세테이트 공중합체, 폴리우레탄, 폴리스티렌 및 폴리(에틸렌 글리콜)과 이들의 공중합체를 포함하는, 근적외선에서 볼 수 있는 의료기기 코팅용 형광성 고분자 도막.