Products of manufacture having tantalum coated nanostructures, and methods of making and using themIn alternative embodiments, the invention provides products (articles) of manufacture comprising nanostructures such as nanotubes having a surface comprising tantalum. In alternative embodiments, products of manufacture of the invention include nanostructures, e.g., nanotubes, nanowire, nanopore, and the like comprising a surface layer of tantalum. In alternative embodiments, products or articles of manufacture of the invention are bioimplants, and the tantalum-surface-coated nanostructures of the invention provide increased bioactivity and bone forming ability. In alternative embodiments, products or articles of manufacture of the invention, e.g., bioimplants, comprising the tantalum-surface-coated nanostructures of the invention are used for in vitro, ex vivo and in vivo testing, implants, biomedical devices and therapeutics.Product or manufacture article or device or an implant, it comprises: nanostructured or nanometer framework,wherein said nanostructured or nanometer framework on its part surface, its substantially on all surfaces or on its all surfaces by below cover or apply: fully or its substantially comprise fully or partly tantalum (ta), ta or ta alloy, ta oxide or ta 2o 5coating or outer covering or the skin of coating, crystallization tantalum (ta) or amorphism ta, wherein described coating optionally, outer covering or skin comprise at least about 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or more tantalum (ta), ta alloy, ta oxide or ta alloyed oxide or ta 2o 5coating, crystallization tantalum (ta) or amorphism ta, or by least about 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or more tantalum (ta), ta alloy, ta oxide or ta alloyed oxide or ta 2o 5coating, crystallization tantalum (ta) or amorphism ta form, and optionally at least about 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or more or up to approximately 99.9% more or approximately 1% to 99.5% described nanostructured or nanometer framework by tantalum (ta), ta alloy, ta oxide or ta alloyed oxide or ta 2o 5coating, crystallization tantalum (ta) or amorphism ta covering, coating or cambium layer: and optionally at least about 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or more or covered by described nanostructured or nanometer framework up to approximately 99.9% following material more or approximately 1% to 99.5%, apply or cambium layer: described product, manufacture article, device or implant, or described product, manufacture the surface of article, device or implant, or described product, manufacture coating or outer covering, skin or the outer surface of article, device or implant.
탄탈룸 코팅된 나노구조를 갖는 제조산물, 이를 제조 및 사용하는 방법대안적인 실시양태에서, 본 발명은 탄탈룸을 포함하는 표면을 갖는 나노튜브와 같은 나노구조를 포함하는 제조산물(물품)을 제공한다. 대안적인 실시양태에서, 본 발명의 제조산물은 탄탈룸 표면층을 포함하는 나노구조, 예를 들어, 나노튜브, 나노와이어, 나노포어 등을 포함한다. 대안적인 실시양태에서, 본 발명의 제조산물 또는 제조물품은 바이오임플란트이며, 본 발명의 탄탈룸-표면-코팅된 나노구조는 생물활성 및 골 형성능의 증가를 제공한다. 대안적인 실시양태에서, 본 발명의 제조산물 또는 제조물품, 예를 들어, 본 발명의 탄탈룸-표면-코팅된 나노구조를 포함하는 바이오임플란트는 시험관내, 생체외 및 생체내 실험, 임플란트, 생물의학적 디바이스 및 요법에 사용된다.나노구조(nanostructure) 또는 나노구조체(nanoarchitecture)를 포함하며,여기에서 상기 나노구조 또는 나노구조체는 부분적으로 그의 실질적으로 모든 또는 모든 표면이 피복되거나 코팅되고, 코팅 또는 외부(outer) 피복 또는 외부 층이 전체로 또는 그의 실질적인 전체로 또는 부분적으로 탄탈룸(Ta), Ta 또는 Ta 합금, Ta 옥사이드 또는 Ta2O5 코팅, 결정성 탄탈룸(Ta), 또는 무정형 Ta를 포함하며,여기에서 임의로 상기 코팅, 외부 피복 또는 외부 층은 적어도 약 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% 또는 그 이상의 탄탈룸(Ta), Ta 합금, Ta 또는 Ta 합금 옥사이드 또는 Ta2O5 코팅, 결정성 탄탈룸(Ta), 또는 무정형 Ta를 포함하거나 이로 구성되고, 임의로 적어도 약 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% 또는 그 이상, 또는 약 99.9% 이하 또는 초과, 또는 약 1% 내지 99.5%의 나노구조 또는 나노구조체가 탄탈룸(Ta), Ta 합금, Ta 또는 Ta 합금 옥사이드 또는 Ta2O5 코팅, 결정성 탄탈룸(Ta), 또는 무정형 Ta로 피복되거나, 코팅되며, 임의로 적어도 약 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% 또는 그 이상, 또는 약 99.9% 이하 또는 초과, 또는 약 1% 내지 99.5%의 제조산물, 제조물품(product, article of manufacture), 디바이스 또는 임플란트; 또는 제조산물, 제조물품, 디바이스 또는 임플란트의 표면; 또는 제조산물, 제조물품, 디바이스 또는 임플란트의 코팅 또는 외부 피복, 외부 층 또는 외부 표면이 상기 나노구조 또는 나노구조체로 피복되거나 코팅된 것으로 이루어진, 제조산물 또는 제조물품, 또는 디바이스 또는 임플란트.