Derivatives and methods of treating hepatitis B infectionsProvided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.A kind of 1. compound of Formulas IOr its pharmaceutically acceptable salt,WhereinW1N, NR are each independently selected from WaAnd CRa, wherein W1It is NR with one of Wa；X is N or CRb；Y is selected from chemical bond ,-C (O)-and-SO2-；Z is selected from-(CR5R6)m-、-(CR5R6)mO-、-(CR5R6)mCR5=CR5-、-(CR5R6)m-C3-C6- cycloalkylidene-and- (CR5R6)m-NR7-；R1Selected from C6-C12- aryl and C1-C9- heteroaryl, wherein aryl and heteroaryl are optionally each independent by 1,2,3 or 4 Ground is selected from-OH, halogen, C1-C6- alkyl, C1-C6- haloalkyl ,-O-C1-C6- alkyl, C1-C6- alkyl-OH, CN and C (O) H's Group substitutes；R2At each occurrence independently selected from H ,-OH, halogen, C1-C6- alkyl, C1-C6- haloalkyl ,-O-C1-C6- alkyl and C1-C6- alkyl-OH；R3At each occurrence independently selected from H ,-OH, halogen, C1-C6- alkyl, C1-C6- haloalkyl ,-O-C1-C6- alkyl and C1-C6- alkyl-OH；R4Selected from C1-C6- alkyl, (CR8R9)p-C3-C8- cycloalkyl, (CR8R9)p-C2-C8- heterocyclic radical, (CR8R9)p-C6-C12- virtue Base and (CR8R9)p-C1-C9- heteroaryl, wherein alkyl, cycloalkyl, heterocyclic radical, aryl and heteroaryl are optionally by 1,2,3 or 4 It is each independently selected from-OH, halogen, CN, C1-C6- alkyl, C1-C6- haloalkyl ,-O-C1-C6- alkyl, C (O) N (Rf)2、C (O)ORf、-OCH2C(O)ORf、-SO2Rf、C1-C6- alkyl-OH, C3-C8- cycloalkyl and C6The group substitution of-aryl；R5At each occurrence independently selected from H ,-OH, halogen, C1-C6- alkyl, C1-C6- haloalkyl ,-O-C1-C6- alkyl and C1-C6- alkyl-OH；Alternatively, R4And R5Optionally connect to form heterocycle；R6At each occurrence independently selected from H ,-OH, halogen, C1-C6- alkyl, C1-C6- haloalkyl ,-O-C1-C6- alkyl and C1-C6- alkyl-OH；R7Selected from H, C1-C6- alkyl and C1-C6- alkyl-OH；R8At each occurrence independently selected from H ,-OH, halogen, C1-C6- alkyl, C1-C6- haloalkyl ,-O-C1-C6- alkyl and C1-C6- alkyl-OH；R9At each occurrence independently selected from H ,-OH, halogen, C1-C6- alkyl, C1-C6- haloalkyl ,-O-C1-C6- alkyl and C1-C6- alkyl-OH；RaSelected from H, C1-C6- alkyl and C1-C6- alkyl-OH；RbSelected from H and C1-C6- alkyl；RfAt each occurrence independently selected from H and C1-C6- alkyl；M is 0,1,2,3 or 4；N is 0,1,2 or 3；AndP is 0,1,2,3 or 4.
B형 간염 감염을 치료하는 유도체 및 그 방법HBV 감염 치료를 필요로 하는 대상에서 HBV 감염 치료에 유용한 화합물, 이들의 약제학적 조성물, 및 상기 대상에서 HBV 감염을 억제하거나, 방지하거나, 예방하는 방법이 본 명세서에 제공된다.하기 화학식 I의 화합물 또는 이의 약제학적으로 허용가능한 염:[이미지]상기 식에서,W1 및 W는 각각 독립적으로 N, NRa 및 CRa로부터 선택되며, 여기서, W1 및 W 중 하나는 NRa이고;X는 N 또는 CRb이며;Y는 결합(bond), -C(O)- 및 -SO2-로부터 선택되고;Z는 -(CR5R6)m-, -(CR5R6)mO-, -(CR5R6)mCR5=CR5-, -(CR5R6)m-C3-C6-사이클로알킬렌- 및 -(CR5R6)m-NR7-로부터 선택되며;R1은 C6-C12-아릴 및 C1-C9-헤테로아릴로부터 선택되고, 여기서, 아릴 및 헤테로아릴은 각각 독립적으로 -OH, 할로, C1-C6-알킬, C1-C6-할로알킬, -O-C1-C6-알킬, C1-C6-알킬-OH, CN 및 C(O)H로부터 선택되는 1, 2, 3 또는 4개의 기로 임의로 치환되며;R2는, 각각의 경우에, H, -OH, 할로, C1-C6-알킬, C1-C6-할로알킬, -O-C1-C6-알킬 및 C1-C6-알킬-OH로부터 독립적으로 선택되고;R3은, 각각의 경우에, H, -OH, 할로, C1-C6-알킬, C1-C6-할로알킬, -O-C1-C6-알킬 및 C1-C6-알킬-OH로부터 독립적으로 선택되며;R4는 C1-C6-알킬, (CR8R9)p-C3-C8-사이클로알킬, (CR8R9)p-C2-C8-헤테로사이클릴, (CR8R9)p-C6-C12-아릴 및 (CR8R9)p-C1-C9-헤테로아릴로부터 선택되고, 여기서, 알킬, 사이클로알킬, 헤테로사이클릴, 아릴 및 헤테로아릴은 각각 독립적으로 -OH, 할로, CN, C1-C6-알킬, C1-C6-할로알킬, -O-C1-C6-알킬, C(O)N(Rf)2, C(O)ORf, -OCH2C(O)ORf, -SO2Rf, C1-C6-알킬-OH, C3-C8-사이클로알킬 및 C6-아릴로부터 선택되는 1, 2, 3 또는 4개의 기로 임의로 치환되며;R5는, 각각의 경우에, H, -OH, 할로, C1-C6-알킬, C1-C6-할로알킬, -O-C1-C6-알킬 및 C1-C6-알킬-OH로부터 독립적으로 선택되거나;R4 및 R5는 임의로 결합하여 헤테로사이클릭 고리를 형성하고;R6은, 각각의 경우에, H, -OH, 할로, C1-C6-알킬, C1-C6-할로알킬, -O-C1-C6-알킬 및 C1-C6-알킬-OH로부터 독립적으로 선택되며;R7은 H, C1-C6-알킬 및 C1-C6-알킬-OH로부터 선택되고;R8은, 각각의 경우에, H, -OH, 할로, C1-C6-알킬, C1-C6-할로알킬, -O-C1-C6-알킬 및 C1-C6-알킬-OH로부터 독립적으로 선택되며;R9는, 각각의 경우에, H, -OH, 할로, C1-C6-알킬, C1-C6-할로알킬, -O-C1-C6-알킬 및 C1-C6-알킬-OH로부터 독립적으로 선택되고;Ra는 H, C1-C6-알킬 및 C1-C6-알킬-OH로부터 선택되며;Rb는 H 및 C1-C6-알킬로부터 선택되고;Rf는, 각각의 경우에, H 및 C1-C6-알킬로부터 독립적으로 선택되며;m은 0, 1, 2, 3 또는 4이고;n은 0, 1, 2 또는 3이며;p는 0, 1, 2, 3 또는 4이다.