3, 3 -(disubstituted) cyclohexan -1 -ols monomers and related compoundsThe present invention relates to novel 3,3-(disubstituted)cyclohexan-1-ol monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).The compound or pharmaceutically acceptable salt thereof class of general formula (i): wherein:r 1be-(cr 4r 5) nc (o) o (cr 4r 5) mr 6,-(cr 4r 5) nc (o) nr 4(cr 4r 5) mr 6,-(cr 4r 5) no (cr 4r 5) mr 6, or-(cr 4r 5) rr 6wherein moieties may be not to be substituted, and also can be replaced to several halogen atoms by 1; m is 0 to 2n is 0 to 4r is 0 to 6r 4and r 5be respectively hydrogen or c 1-2alkyl; r 6be hydrogen, methyl, hydroxyl, aryl, halogenated aryl, aryloxy group c 1-3alkyl, halo aryloxy group c 1-3alkyl, 2, the 3-dihydro is for indenyl, indenyl, c 7-11poly-cycloalkyl, tetrahydrofuran base, furyl, thp trtrahydropyranyl, pyranose, tetrahydro-thienyl, thienyl, tetrahydro thiapyran base, thiapyran base, c 3-6cycloalkyl, or the c of 1 or 2 unsaturated bond is arranged 4-6cyclic hydrocarbon radical, cycloalkyl wherein or heterocyclic moiety can be unsubstituted, also can be replaced by 1-3 methyl, 1 ethyl or a hydroxyl; condition is:a) work as r 6when being hydroxyl, m is 2; or b) work as r 6when being hydroxyl, r is 2 to 6; or c) work as r 6when being 2-thp trtrahydropyranyl, 2-tetrahydro thiapyran base, 2-tetrahydrofuran base or 2-tetrahydro-thienyl, m is 1 or 2; or d) work as r 6be the 2-thp trtrahydropyranyl, the 2-tetrahydro thiapyran base, 2-tetrahydrofuran base or 2-tetrahydro-thienyl, r are 1 to 6; e) when n be 1, m is 0 o'clock, at-(cr 4r 5) no (cr 4r 5) mr 6in, r 6not h; x is yr 2, f, nr 4r 5or methanamide; y is o or s (o) m 'm ' is 0,1 or 2;x 2be o or nr 8x 3be hydrogen or x; x 4be h, r 9, or 8, cn, c (o) r 8, c (o) or 8, c (o) nr 8r 8or nr 8r 8r 2independently be selected from be not substituted or by 1 or several halogen replace-ch 3or-ch 2ch 3, s is 0 to 4;w is the alkyl of 2 to 6 carbon atoms, the alkenyl of 2 to 6 carbon atoms, or the alkynyl of 2 to 6 carbon atoms;r 3be coor 14, c (o) nr 4r 14or r 7z isor 14，or 15，sr 14，s(o) m′r 7，s(o) 2nr 10r 14，nr 10r 14， nr 14c(o)r 9，nr 10c(y′)r 14，nr 10c(o)or 7，nr 10c(y′)nr 10r 14， nr 10s(o) 2nr 10r 14，nr 10c(ncn)nr 10r 14，nr 10s(o) 2r 7， nr 10c(cr 4no 2)nr 10r 14，nr 10c(ncn)sr 9，nr 10c(cr 4no 2)sr 9， nr 10c (nr 10) nr 10r 14, nr 10c (o) c (o) nr 10r 14, or nr 10c (o) c (o) or 14y ' is o or s;r 7be-(cr 4r 5) qr 12or c 1-6alkyl, wherein r 12or c 1-6alkyl is unsubstituted, is perhaps replaced one or many by methyl or ethyl, and methyl here or ethyl be unsubstituted or replaced by 1-3 fluorine, or by following substituent group replacement one or many: -f，-br，-cl，-no 2，-nr 10r 11，-c(o)r 8，-co 2r 8， -o(ch 2) 2-4or 8，-o(ch 2) 2-4or 8，-o(ch 2) qr 8，-cn，-c(o)nr 10r 11， -o(ch 2) qc(o)nr 10r 11，-o(ch 2) qc(o)r 9，-nr 10c(o)nr 10r 11，-nr 10c(o)r 11， -nr 10c(o)or 9，-nr 10c(o)r 13，-c(nr 10)nr 10r 11，-c(ncn)nr 10r 11， -c(ncn)sr 9，-nr 10c(ncn)sr 9，-nr 10c(ncn)nr 10r 11，-nr 10s(o) 2r 9， -s (o) m 'r 9,-nr 10c (o) c (o) nr 10r 11,-nr 10c (o) c (o) r 10, or r 13q is 0,1 or 2;r 12be r 13, c 3-7cycloalkyl, or the aryl or the heteroaryl that do not replace or replace, be selected from (2-, 3-or 4-pyridine radicals), pyrimidine radicals, pyrazolyl, (1-or 2-imidazole radicals), pyrrole radicals, piperazinyl, piperidyl, morpholinyl, furyl, (2-or 3-thienyl), quinolyl, naphthyl or phenyl; r 8be hydrogen or r 9r 9be the optional c that is replaced by 1 to 3 fluorine 1-4alkyl; r 10be or 8or r 11r 11be hydrogen or the c that is not substituted or replaced by 1 to 3 fluorine 1-4alkyl; perhaps work as r 10and r 11form nr 10r 11the time, they can form 5-7 person's ring, carbon containing or carbon and one or more hetero atom that is selected from o, n or s in the ring jointly with n; r 13be replace or unsubstituted following heterocyclic aryl group: oxazolidinyl, oxazolyl, thiazolyl, pyrazolyl, triazolyl, tetrazole radical, imidazole radicals, imidazolidinyl, thiazolidinyl, isoxazolyl, oxadiazole base and thiadiazolyl group; r 13at r 12or r 13last replacement, these rings connect per second r by the c atom 13ring can not be substituted or by 1 to 2 c 1-2alkyl replaces, this c 1-2alkyl can be unsubstituted, or has 1 to 3 to replace fluorine atom on methyl; r 14be hydrogen or r 7perhaps work as r 8and r 14form nr 8r 14the time, they can form 5-7 person's ring, carbon containing or carbon and 1 or several other hetero atom o, n or s on the ring jointly with nitrogen; r 15be c (o) r 14, c (o) nr 4r 14, s (o) qr 7or s (o) qnr 8r 14, wherein q is 0,1 or 2, condition is:(f) r 7not c unsubstituted or that replaced by 1 to 3 f 1-4alkyl.
3,3-(이치환) 시클로헥산-1-올 단량체 및 관련화합물본 발명은 반복되는 단위 기재상에 약 0.1 % - 2 % 의 아미노알킬실옥산 함량을 갖는 아미노알킬실리콘을 함유하는 방햐제, 향료, 냉각제, 향균 조성물에 관한 것이다. 상기 조성물은 월등한 표면-잔류성, 내충격성 및/또는 효능을 나타낸다.반복되는 단위 기재상에 약 0.1% - 2% 의 아미노알킬실옥산 함량을 갖는 아미노알킬실리콘을 함유하는 방향제, 향료, 냉각제 또는 항균 조성물.