SOMATOSTATIN MODULATORS AND USES THEREOFDescribed herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.A compound of Formula (I), or a pharmaceutically acceptable salt, pharmaceutically acceptable solvate, diastereomeric mixture, enantiomer or prodrug thereof:Formula (I)wherein:X is C-R1 or N;R1 is - R2R3, -OR2, or R4;R2 is hydrogen, substituted or unsubstituted Ci-C4alkyl, substituted or unsubstituted Ci-C4fluoroalkyl, substituted or unsubstituted Ci-C4heteroalkyl, or substituted or unsubstituted C3-C6cycloalkyl;R3 is hydrogen, substituted or unsubstituted Ci-C4alkyl, substituted or unsubstituted Ci-C4fluoroalkyl, substituted or unsubstituted Ci-C4heteroalkyl, or substituted or unsubstituted C3-C6cycloalkyl;or R2 and R3 are taken together with the N atom to which they are attached to form a substituted or unsubstituted 4-membered, substituted or unsubstituted 5-membered or substituted or unsubstituted 6-membered N-containing heterocyclic ring;R4 is F, CI, Br, -CN, substituted or unsubstituted Ci-C4alkyl, substituted orunsubstituted Ci-C4fluoroalkyl, substituted or unsubstituted Ci-C4alkoxy, -SCi- C4alkyl, -S(=0)Ci-C4alkyl , -S(=0)2-Ci-C4alkyl, substituted or unsubstituted Ci- C4heteroalkyl, substituted or unsubstituted C3-C6cycloalkyl, -C02R15, -C(=0)N(Ri3)2; Ra is or R -0-N=CH-;R is hydrogen, substituted or unsubstituted Ci-C6alkyl, substituted or unsubstituted Ci- Cefluoroalkyl, substituted or unsubstituted Ci-C6heteroalkyl, substituted or unsubstituted monocyclic carbocycle, or substituted or unsubstituted monocyclic heterocycle,R5 is hydrogen, substituted or unsubstituted Ci-C4alkyl, substituted or unsubstituted Ci- C4fluoroalkyl, substituted or unsubstituted C2-C4alkenyl, or substituted or unsubstituted C3-C6cycloalkyl;each R6 and R7 is independently hydrogen, halogen, substituted or unsubstituted Ci- C4alkyl, substituted or unsubstituted Ci-C4fluoroalkyl, substituted or unsubstituted C2-C4alkenyl, substituted or unsubstituted C2-C4alkynyl, substituted or unsubstituted Ci-C6heteroalkyl, substituted or unsubstituted monocyclic carbocycle, substituted or unsubstituted monocyclic heterocycle, -CN, -OR15, -C02R15, -C(=0)N(R15)2, - C(=0)N(R15)OR15, -N(R15)2, - R15C(=0)R15, - R15C(=0)OR15, -OC(=0)N(R15)2, - R15C(=0)N(R15)2, - R15C(=0) R15OR15, -C(R15)=N-OR15, -SR15, -S(=0)R14, - S02R14, or -S02N(R15)2;or R6 and an adjacent R7 are taken together with the intervening atoms to which they are attached to form a substituted or unsubstituted 5-membered or 6-membered ring;R8 and R9 are independently hydrogen, halogen, substituted or unsubstituted Ci-C4alkyl, substituted or unsubstituted Ci-C4fluoroalkyl, substituted or unsubstituted Ci- C6heteroalkyl, substituted or unsubstituted monocyclic carbocycle, substituted or unsubstituted monocyclic heterocycle, -CN, -OR15, -C02R15, -C(=0)N(R15)2, - C(=0)N(R15)OR15, -N(R15)2, -CH2N(R15)2, -NR15C(=0)R15, -NR15C(=0)OR15, - OC(=0)N(R15)2, -NR15C(=0)N(R15)2, -NR15C(=0)NR15OR15, -C(R15)=N-OR15, - SR15, -S(=0)R14, -S02R14, or -S02N(R15)2;X1 is N or C-R10;R10 is hydrogen, F, CI, Br, -CN, -N(R15)2, substituted or unsubstituted d-C4alkyl, substituted or unsubstituted Ci-C4alkoxy, substituted or unsubstituted Ci- C4fluoroalkyl, substituted or unsubstituted Ci-C4fluoroalkoxy, substituted or unsubstituted Ci-C4heteroalkyl, or substituted C3-C6cycloalkyl;X2 is C-R7 or N;X3 is C-R7 or N;R11 and R12 are independently hydrogen, substituted or unsubstituted Ci-C6alkyl,substituted or unsubstituted Ci-Cefluoroalkyl, substituted or unsubstituted Ci- C6heteroalkyl, substituted or unsubstituted C3-C6cycloalkyl, or substituted or unsubstituted C3-C5heterocycloalkyl that has 1 O atom;or R11 and R12 are taken together with the nitrogen atom to which they are attached to form a substituted or unsubstituted N-containing heterocyclic ring;R13 is hydrogen, -OR15, -N(R15)2, -CN, -C02R14, -C(=0)N(R15)2, substituted orunsubstituted Ci-C6 alkyl, and substituted or unsubstituted Ci-C6fluoroalkyl, substituted or unsubstituted Ci-C6heteroalkyl, substituted or unsubstituted monocyclic carbocycle, or substituted or unsubstituted monocyclic heterocycle; or R12 and R13 are taken together with the intervening atoms to which they are attached to form a substituted or unsubstituted N-containing heterocyclic ring;each R14 is independently selected from substituted or unsubstituted Ci-C6alkyl,substituted or unsubstituted Ci-C6heteroalkyl, substituted or unsubstituted C3- C7cycloalkyl, substituted or unsubstituted monocyclic C2-C6heterocycloalkyl, substituted or unsubstituted phenyl, and substituted or unsubstituted monocyclic heteroaryl;each R15 is independently selected from hydrogen, substituted or unsubstituted Ci- C6alkyl, substituted or unsubstituted Ci-C6heteroalkyl, substituted or unsubstituted C3-C7cycloalkyl, substituted or unsubstituted monocyclic C2-C6heterocycloalkyl, substituted or unsubstituted phenyl, and substituted or unsubstituted monocyclic heteroaryl;or two R15 on the same N atom are taken together with the N atom to which they are attached to form an substituted or unsubstituted N-containing h...
소마토스타틴 조절제 및 이의 용도본원에서 기재된 것은 소마토스타틴 조절제인 화합물, 이러한 화합물의 제조 방법, 이러한 화합물을 포함하는 약학적 조성물 및 의약, 및 소마토스타틴 활성의 조절로부터 이익을 얻을 수 있는 병태, 질환 또는 장애의 치료에서 이러한 화합물을 사용하는 방법이다.하기 화학식 (I)의 화합물, 또는 이의 약학적으로 허용 가능한 염, 약학적으로 허용 가능한 용매화물, 부분입체 이성질체 혼합물, 거울상 이성질체 또는 프로드러그: 식 중: X는 C-R1 또는 N이고; R1은 -NR2R3, -OR2, 또는 R4이며; R2는 수소, 치환되거나 비치환된 C1-C4알킬, 치환되거나 비치환된 C1-C4플루오로알킬, 치환되거나 비치환된 C1-C4헤테로알킬, 또는 치환되거나 비치환된 C3-C6시클로알킬이고; R3는 수소, 치환되거나 비치환된 C1-C4알킬, 치환되거나 비치환된 C1-C4플루오로알킬, 치환되거나 비치환된 C1-C4헤테로알킬, 또는 치환되거나 비치환된 C3-C6시클로알킬이며; 또는 R2 및 R3는 이들이 결합된 N 원자와 함께, 치환되거나 비치환된 4원, 치환되거나 비치환된 5원 또는 치환되거나 비치환된 6원 N 함유 헤테로시클릭 고리를 형성하고;R4는 F, Cl, Br, -CN, 치환되거나 비치환된 C1-C4알킬, 치환되거나 비치환된 C1-C4플루오로알킬, 치환되거나 비치환된 C1-C4알콕시, -SC1-C4알킬, -S(=O)C1-C4알킬, -S(=O)2-C1-C4알킬, 치환되거나 비치환된 C1-C4헤테로알킬, 치환되거나 비치환된 C3-C6 시클로알킬, -CO2R15, -C(=O)N(R15)2이며;Ra는  또는 Rb-O-N=CH-이고;Rb는 수소, 치환되거나 비치환된 C1-C6알킬, 치환되거나 비치환된 C1-C6플루오로알킬, 치환되거나 비치환된 C1-C6헤테로알킬, 치환되거나 비치환된 모노시클릭 카르보사이클, 또는 치환되거나 비치환된 모노시클릭 헤테로사이클이며,R5는 수소, 치환되거나 비치환된 C1-C4알킬, 치환되거나 비치환된 C1-C4플루오로알킬, 치환되거나 비치환된 C2-C4알케닐, 또는 치환되거나 비치환된 C3-C6시클로알킬이고;각각의 R6 및 R7은 독립적으로 수소, 할로겐, 치환되거나 비치환된 C1-C4알킬, 치환되거나 비치환된 C1-C4플루오로알킬, 치환되거나 비치환된 C2-C4알케닐, 치환되거나 비치환된 C2-C4알키닐, 치환되거나 비치환된 C1-C6헤테로알킬, 치환되거나 비치환된 모노시클릭 카르보사이클, 치환되거나 비치환된 모노시클릭 헤테로사이클, -CN, -OR15, -CO2R15, -C(=O)N(R15)2, -C(=O)N(R15)OR15, -N(R15)2, -NR15C(=O)R15,-NR15C(=O)OR15,-OC(=O)N(R15)2, -NR15C(=O)N(R15)2,-NR15C(=O)NR15OR15, -C(R15)=N-OR15, -SR15, -S(=O)R14, -SO2R14, 또는 -SO2N(R15)2이며;또는 R6 및 인접한 R7은 이들이 결합된 개재 원자와 함께, 치환되거나 비치환된 5원 또는 6원 고리를 형성하고;R8 및 R9는 독립적으로 수소, 할로겐, 치환되거나 비치환된 C1-C4알킬, 치환되거나 비치환된 C1-C4플루오로알킬, 치환되거나 비치환된 C1-C6헤테로알킬, 치환되거나 비치환된 모노시클릭 카르보사이클, 치환되거나 비치환된 모노시클릭 헤테로사이클, -CN, -OR15, -CO2R15, -C(=O)N(R15)2, -C(=O)N(R15)OR15, -N(R15)2, -CH2N(R15)2, -NR15C(=O)R15,-NR15C(=O)OR15,-OC(=O)N(R15)2, -NR15C(=O)N(R15)2,-NR15C(=O)NR15OR15, -C(R15)=N-OR15, -SR15, -S(=O)R14, -SO2R14, 또는 -SO2N(R15)2이며;X1은 N 또는 C-R10이고;R10은 수소, F, Cl, Br, -CN, -N(R15)2, 치환되거나 비치환된 C1-C4알킬, 치환되거나 비치환된 C1-C4알콕시, 치환되거나 비치환된 C1-C4플루오로알킬, 치환되거나 비치환된 C1-C4플루오로알콕시, 치환되거나 비치환된 C1-C4헤테로알킬, 또는 치환된 C3-C6시클로알킬이며; X2는 C-R7 또는 N이고; X3은 C-R7 또는 N이며; R11 및 R12는 독립적으로 수소, 치환되거나 비치환된 C1-C6알킬, 치환되거나 비치환된 C1-C6플루오로알킬, 치환되거나 비치환된 C1-C6헤테로알킬, 치환되거나 비치환된 C3-C6시클로알킬, 또는 1개의 O 원자를 갖는 치환되거나 비치환된 C3-C5헤테로시클로알킬이고;또는 R11 및 R12는 이들이 결합된 질소 원자와 함께, 치환되거나 비치환된 N 함유 헤테로시클릭 고리를 형성하며; R13은 수소, -OR15, -N(R15)2, -CN, -CO2R14, -C(=O)N(R15)2, 치환되거나 비치환된 C1-C6 알킬, 및 치환되거나 비치환된 C1-C6플루오로알킬, 치환되거나 비치환된 C1-C6헤테로알킬, 치환되거나 비치환된 모노시클릭 카르보사이클, 또는 치환되거나 비치환된 모노시클릭 헤테로사이클이고;또는 R12 및 R13은 이들이 결합된 개재 원자와 함께, 치환되거나 비치환된 N 함유 헤테로시클릭 고리를 형성하며;각각의 R14는 독립적으로 치환되거나 비치환된 C1-C6알킬, 치환되거나 비치환된 C1-C6헤테로알킬, 치환되거나 비치환된 C3-C7시클로알킬, 치환되거나 비치환된 모노시클릭 C2-C6헤테로시클로알킬, 치환되거나 비치환된 페닐, 및 치환되거나 비치환된 모노시클릭 헤테로아릴로부터 선택되고; 각각의 R15는 독립적으로 수소, 치환되거나 비치환된 C1-C6알킬, 치환되거나 비치환된 C1-C6헤테로알킬, 치환되거나 비치환된 C3-C7시클로알킬, 치환되거나 비치환된 모노시클릭 C2-C6헤테로시클로알킬, 치환되거나 비치환된 페닐, 및 치환되거나 비치환된 모노시클릭 헤테로아릴로부터 선택되며;또는 동일한 N 원자 상의 2개의 R15는 이들이 결합된 N 원자와 함께, 치환되거나 비치환된 N 함유 헤테로사이클을 형성한다.