PROPHYLACTIC OR THERAPEUTIC AGENT FOR AUTISM SPECTRUM DISORDERProvided is a prophylactic or therapeutic agent for autism spectrum disorder. The agent comprises compound (I) that has affinity to melatonin receptors. A compound represented by formula (I) [whereinthe meaning of each symbol is as defined in the description] or a salt thereof.Prevention or the therapeutic agent of autism spectrum disorder, contain compound or its salt selected from following as active constituent:n-[2- (2- methyl -6,7- dihydro -8h- yin bings [5,4-d][1,3]oxazole -8- subunits) yi ji ]acetamide,n-[2- (2- methyl -6h- yin bings [5,4-d][1,3]oxazole -8- bases) yi ji ]acetamide,n-[2- (2- methyl -6,7- dihydro -8h- yin bings [5,4-d][1,3]oxazole -8- subunits) yi ji ]propionamide,n-{2-[2- (4- phenyl butyls) -6,7- dihydro -8h- yin bings [5,4-d][1,3]oxazole -8- ya jis ]ethyl } acetamide,n-[2- (2- methyl -6,7- dihydro -8h- yin bings [5,4-d][1,3]thiazole -8- subunits) yi ji ]acetamide,n-[2- (2- methyl -7,8- dihydro -6h- yin bings [5,4-d][1,3]oxazole -8- bases) yi ji ]acetamide,(r)-n-[2- (2- methyl -7,8- dihydro -6h- yin bings [5,4-d][1,3]oxazole -8- bases) yi ji ]acetamide,(s)-n-[2- (2- methyl -7,8- dihydro -6h- yin bings [5,4-d][1,3]oxazole -8- bases) yi ji ]acetamide,n-[2- (2- methyl -7,8- dihydro -6h- yin bings [5,4-d][1,3]oxazole -8- bases) yi ji ]propionamide,(r)-n-[2- (2- methyl -7,8- dihydro -6h- yin bings [5,4-d][1,3]oxazole -8- bases) yi ji ]propionamide,(s)-n-[2- (2- methyl -7,8- dihydro -6h- yin bings [5,4-d][1,3]oxazole -8- bases) yi ji ]propionamide,n-[2- (2- methyl -7,8- dihydro -6h- yin bings [5,4-d][1,3]thiazole -8- bases) yi ji ]acetamide,(r)-n-[2- (2- methyl -7,8- dihydro -6h- yin bings [5,4-d][1,3]thiazole -8- bases) yi ji ]acetamide,(s)-n-[2- (2- methyl -7,8- dihydro -6h- yin bings [5,4-d][1,3]thiazole -8- bases) yi ji ]acetamide,n-[2- (2- ethyl -7,8- dihydro -6h- yin bings [5,4-d][1,3]oxazole -8- bases) yi ji ]acetamide,(r)-n-[2- (2- ethyl -7,8- dihydro -6h- yin bings [5,4-d][1,3]oxazole -8- bases) yi ji ]acetamide,(s)-n-[2- (2- ethyl -7,8- dihydro -6h- yin bings [5,4-d][1,3]oxazole -8- bases) yi ji ]acetamide,n-[2- (2- methoxyl group -7,8- dihydro -6h- yin bings [5,4-d][1,3]oxazole -8- bases) yi ji ]acetamide,(r)-n-[2- (2- methoxyl group -7,8- dihydro -6h- yin bings [5,4-d][1,3]oxazole -8- bases) yi ji ]acetamide, and(s)-n-[2- (2- methoxyl group -7,8- dihydro -6h- yin bings [5,4-d][1,3]oxazole -8- bases) yi ji ]acetamide.
자폐 스펙트럼 장애의 예방 또는 치료제멜라토닌 수용체에 대해 친화성을 갖는 화합물 (I) 을 포함하는, 자폐 스펙트럼 장애의 예방 또는 치료제가 제공된다. 식 (I) 로 나타나는 화합물 또는 이의 염. [이미지] [식 중, 각각의 부호의 의미는 본 명세서에 정의된 바와 같음].활성 성분으로서 하기로부터 선택되는 화합물 또는 이의 염을 포함하는 자폐 스펙트럼 장애의 예방 또는 치료제: N-[2-(2-메틸-6,7-디히드로-8H-인데노[5,4-d][1,3]옥사졸-8-일리덴)에틸]아세트아미드, N-[2-(2-메틸-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]아세트아미드, N-[2-(2-메틸-6,7-디히드로-8H-인데노[5,4-d][1,3]옥사졸-8-일리덴)에틸]프로피온아미드, N-{2-[2-(4-페닐부틸)-6,7-디히드로-8H-인데노[5,4-d][1,3]옥사졸-8-일리덴]에틸}아세트아미드, N-[2-(2-메틸-6,7-디히드로-8H-인데노[5,4-d][1,3]티아졸-8-일리덴)에틸]아세트아미드, N-[2-(2-메틸-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]아세트아미드, (R)-N-[2-(2-메틸-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]아세트아미드, (S)-N-[2-(2-메틸-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]아세트아미드, N-[2-(2-메틸-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]프로피온아미드, (R)-N-[2-(2-메틸-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]프로피온아미드, (S)-N-[2-(2-메틸-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]프로피온아미드, N-[2-(2-메틸-7,8-디히드로-6H-인데노[5,4-d][1,3]티아졸-8-일)에틸]아세트아미드, (R)-N-[2-(2-메틸-7,8-디히드로-6H-인데노[5,4-d][1,3]티아졸-8-일)에틸]아세트아미드, (S)-N-[2-(2-메틸-7,8-디히드로-6H-인데노[5,4-d][1,3]티아졸-8-일)에틸]아세트아미드, N-[2-(2-에틸-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]아세트아미드, (R)-N-[2-(2-에틸-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]아세트아미드, (S)-N-[2-(2-에틸-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]아세트아미드, N-[2-(2-메톡시-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]아세트아미드, (R)-N-[2-(2-메톡시-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]아세트아미드, 및 (S)-N-[2-(2-메톡시-7,8-디히드로-6H-인데노[5,4-d][1,3]옥사졸-8-일)에틸]아세트아미드.