Question: Was Land of Israel in possession of an Islamic empire in 16th century?, Answer:Yes, Description of Land of Israel: Traditional Jewish name for an area of indefinite geographical extension in the Southern Levant., Fact1: Land of Israel was controlled by the Ottoman Empire in 16th century. , Fact2: The religion of Ottoman Empire was Sunni Islam. 
Step1: Who ruled the geographic region of Israel in the 16th century?, Step2: Was Islam the state religion of #1?, Wikipedia page for step 1: wiki: Israel, Wikipedia page for step 2: wiki: Ottoman Empire, not_definitive_answer: False, incorrect_answer: False