Question: Are tIMP1 , TIMP2 , and TIMP4 increased in aqueous humor from primary open angle glaucoma patients?
Answer: An imbalance among MMPs and TIMPs was found in glaucomatous aqueous humor samples, with a shift toward raised TIMP levels. This may result in the inhibition of MMP activity, leading to an altered ECM composition in the TM and thereby contributing to increased outflow resistance.