Abstract: This study was designed to investigate the effect of middle-wave ultraviolet (UVB) radiation on mast cell functions using mouse ear skin as an in vivo model. Groups of UVB-irradiated BALB/c mice were given an intradermal injection of the mast cell degranulator compound 48/80 into ears at various time intervals (30 min-7 days) after a single exposure to a bank of fluorescent sunlamp tubes (10-100 mJ/cm2). Both the compound-evoked ear swelling response (ESR) and mast cell degranulation were significantly suppressed by preexposure to UVB (25-100 mJ/cm2) after 0 (30 min) to 3 days postirradiation, with a subsequent recovery by day 7. No such effects were observed in mice irradiated with 10 mJ/cm2. The ESR induced by 5-hydroxytryptamine was not significantly affected by UVB radiation during the experimental period. While within this dose range UV radiation itself caused neither loss of mast cell counts nor a measurable degree of degranulation in ear skin, exposure to larger amounts of UV energy (200-500 mJ/cm2) produced tremendous ear swelling with histologic features of mast cell degranulation in an early phase of inflammation. The results suggest that UVB radiation exerts a dual effect on mast cells and that administration of smaller amounts of UVB may alter the mast cell/vasoactive amine system, suppressing ear swelling in response to the degranulator. Vascular reactivities to vasoactive amines were not affected by UVB irradiation. 
Question: Does the abstract contain any numerical data?
Yes