Given Relationship: 'be publish in', Sentence: 'In the January 4 , 2007 edition of the New England Journal of Medicine , a paper was published documenting a British study of over 11,000 Parkinson 's Disease patients , which found that two commonly used Parkinson 's drugs derived from ergot , Pergolide and Cabergoline , may increase the risk of leaky heart valves by up to 700 % .'
published