Comment: Too bad you left out the ones that cost taxpayers the most money of all via medical costs for self-inflicted illness: the tobacco addicts, boozers and obese junk food addicts.  Booze is also the most dangerously impairing popular drug of all (think accidents and violence).  The most physically damaging and the most dangerously impairing popular substances are legal ones, not illicit ones. But its opioid users you think should be singled out for special demonization instead? Sure. Very rational, just, and non-hypocritical of you (not)!