In total , 485 calves ( ≤ 21 d of age ) were enrolled at first diarrhea diagnosis ( fecal score ≥ 2 defined as loose to watery ) and randomly assigned to receive an oral dose of lactoferrin ( 3 g of lactoferrin powder dissolved in 30 mL of water ) or 30 mL of water ( control ) once daily for 3 consecutive days.