Hepatitis B virus Á HepG2.2.15 cell line Á Lentiviral vector Á RNAi Á Doxycycline Abbreviations CP Core promoter DOX Doxycycline DR1 Direct repeat 1 EN2 Enhancer II region HAV Hepatitis A virus HBV Hepatitis B virus HBcAg Hepatitis core antigen HBsAg Hepatitis B surface antigen HBeAg Hepatitis B e antigen HCC Hepatocellular carcinoma HCV Hepatitis C virus HIV Human immunodeficiency virus HSV Herpes simplex virus KRAB Krüppel associated box Electronic supplementary material The online version of this article (