Sentence: To promote FMDV replication , L pro can suppress host antiviral responses by three different mechanisms : ( 1 ) cleavage of eukaryotic translation initiation factor 4 γ ( eIF4G ) to shut off host protein synthesis ; ( 2 ) inhibition of host innate immune responses through restriction of interferon-α/β production ; and ( 3 ) L pro can also act as a deubiquitinase and catalyze deubiquitination of innate immune signaling molecules. 
 Section: method