Immunoglobulin I-set domain
I-set domains are found in several cell adhesion molecules, including vascular (VCAM), intercellular (ICAM), neural (NCAM) and mucosal addressin (MADCAM) cell adhesion molecules, as well as junction adhesion molecules (JAM). I-set domains are also present in several other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signalling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis. Human proteins containing this domain ADAMTSL1, ADAMTSL3, ALPK3, AXL, BOC, C9orf94, CADM2, CADM4, CCDC141, CDON, CEACAM7, CHL1, CILP2, CNTN1, CNTN2, CNTN3, CNTN4, CNTN5, CNTN6, CXADR, DCC, DSCAM, DSCAML1, ESAM, FGFR1, FGFR3, FGFR4, FGFRL1, FLT1, FLT4, FSTL4, FSTL5, HMCN1, HNT, HSPG2, ICAM5, IGFBP7, IGFBPL1, IGSF10, IGSF22, IGSF9, ISLR, KALRN, KAZALD1, KDR, KIAA0626, KIRREL, KIRREL2, KIRREL3, L1CAM, LINGO1, LINGO2, LRFN2, LRFN3, LRFN4, LRFN5, LRIG1, LRIG2, LRIG3, LRIT2, LRIT3, LRRC24, LRRC4B, LRRC4C, LRRN1, LRRN3, LRRN5, LSAMP, MAG, MDGA2, MFAP3L, MUSK, MXRA5, MYBPC1, MYBPC2, MYBPC3, MYBPH, MYBPHL, MYLK, MYOM1, MYOM2, MYOM3, MYOT, MYPN, NCAM1, NCAM2, NEGR1, NEO1, NEXN, NFASC, NGL1, NOPE, NPHS1, NPTN, NRCAM, NRG2, NT, NTRK2, NTRK3, OBSCN, OBSL1, OPCML, PALLD, PAPLN, PDGFRA, PRODH2, PTK7, PTPRD, PTPRF, PTPRS, PTPsigma, PUNC, ROBO1, ROBO2, ROBO3, ROBO4, ROR1,