Estrone sulfotransferase
Estrone sulfotransferase (EST) (), also known as estrogen sulfotransferase, is an enzyme that catalyzes the transformation of an unconjugated estrogen like estrone into a sulfated estrogen like estrone sulfate. It is a steroid sulfotransferase and belongs to the family of transferases, to be specific, the sulfotransferases, which transfer sulfur-containing groups. This enzyme participates in androgen and estrogen metabolism and sulfur metabolism. Steroid sulfatase is an enzyme that catalyzes the reverse reaction, the transfer of a sulfate to an unconjugated estrogen. Reaction In enzymology, an EST is an enzyme that catalyzes the following chemical reaction: 3'-phosphoadenylyl sulfate + estrone adenosine 3',5'-bisphosphate + estrone 3-sulfate Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and estrone, whereas its two products are adenosine 3',5'-bisphosphate and estrone 3-sulfate. The enzyme also catalyzes the same reaction for estradiol, with estradiol sulfate as the product. Types Two enzymes have been identified that together are thought to represent estrone sulfotransferase (EST): SULT1A1 (catalyzes the reactions estradiol to estradiol sulfate and, to a lesser extent than SULT1E1, estrone to estrone sulfate) SULT1E1 (catalyzes the reactions estrone to estrone sulfate and estradiol to estradiol sulfate) Function Structure As of late 2007, 5 structures have been solved for this