SUHW4
Zinc finger protein 280D, also known as Suppressor Of Hairy Wing Homolog 4, SUWH4, Zinc Finger Protein 634, ZNF634, or KIAA1584, is a protein that in humans is encoded by the ZNF280D gene located on chromosome 15q21.3. Gene There are a total of 24 possible exons in any variant of the ZNF280D gene. ZNF280D is oriented on the minus strand of Chromosome 15 and spans 288.396 kb. Surrounding genes at the same locus include TEX9, HMGB1P33, MNS1, LOC645877, and LOC145783. mRNA At least 24 spliced variants have been identified. There are 7 probable alternative promoters. The mRNAs appear to differ by truncation of the 5' end, truncation of the 3' end, presence or absence of 12 cassette exons, overlapping exons with different boundaries, splicing versus retention of 5 introns. The longest splice form contains 4428 bp. Protein Composition and Domains The ZNF280D protein is 979 amino acids in length. The protein contains a domain of unknown function (DUF4195) spanning from amino acid 45 to amino acid 230. DUF4195 (pfam13826) is a family that is found at the N-terminus of metazoan proteins that carry PHD-like zinc-finger domains; the function is unknown. ZNF280D protein also contains five highly conserved Cys2His2-type zinc finger