Mir-143
In molecular biology mir-143 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. mir–143 is highly conserved in vertebrates. mir-143 is thought be involved in cardiac morphogenesis but has also been implicated in cancer. Genomic location mir– 143 is located on chromosome 5 position 33 in the human genome. mir-143 is located very close to mir-145 in the genome and it is speculated that they are transcribed as a bicistronic unit. Their co-transcription means they are frequently studied together in the same cellular pathways and diseases. Expression mir–143 is a direct transcriptional target of the serum response factor, myocardin and nkx2-5. mir-143 expression is also thought to be controlled epigenetically through heart beat. Targets These are known genetic targets for mir–143 and its effect on them: Klf4 – Promotes transcription. ELK1 – Promotes transcription. ADD3 – Represses transcription. F-actin capping protein. FNDC38 – Represses transcription. Tumour metastasis. HK2 – Represses transcription. Glucose-6-phosphate catalyzing enzyme. Raldh2/aldh1a2 – Represses transcription. Involved in heart tube organization. rxrab – Represses transcription. Involved in heart tube organization. KLF5 – Unknown has conserved miR – 143 binding site. MAP3K7– Unknown has conserved miR – 143 binding