Astrotactin
Astrotactin-1, abbreviated ASTN1, is a glycoprotein expressed primarily in the central nervous system. ASTN1 and its counterpart ASTN2 are involved in regulation of adhesion during the radial migration of neurons in the developing CNS. Astrotactin is a neuronal adhesion molecule required for glial-guided migration of young postmitotic neuroblasts with expression is primarily located in the cells of cortical regions of the developing brain including; cerebrum, hippocampus, cerebellum, and olfactory bulb. Biochemical properties ASTN-1 is created via developmental pathways via mRNA, the astrotactin-1 protein is generated from Chromosome 1: 176,861,067-177,164,712 and the Gencode Gene: ENSG00000152092.16 with a base pair size of 303,646 and total Exon count of 23. Composed of 1294 amino acids on average with some variations of 1302, 1228, and 1216 depending on an individual's genetic composition. Astrotactin-1 appears highly conserved as mutations are quite rare with 2 deletions and a single duplication recorded within a sample of 64,114 subjects. ASTN1 features a relatively short amino terminus coupled with a longer carboxyl terminus within the extracellular matrix of their environment that may aid in the protein function of movement. Considered a Multi-pass membrane protein responsible for the neuronal migrations in cortical regions of the brain are guided by a