Dorsal nexus
The dorsal nexus is an area within the dorsal medial prefrontal cortex that serves as an intersection point for multiple brain networks. Research suggests it plays a role in the maintenance and manipulation of information, as well as supporting the control of cognitive functions such as behavior, memory, and conflict resolution. Abnormally increased connectivity between these networks through the dorsal nexus has been associated with certain types of depression. The activity generated by this abnormally high level of connectivity during a depressive state can be identified through magnetic resonance imaging (MRI) and positron emission tomography (PET). Anatomy and function The brain's intrinsic connections are divided into different networks that enable communication between the different structures: The cognitive control network, or executive network (EN), the affective network or somatic network, and the default mode network. These regions are dependent on the dorsal nexus to communicate. The EN is located in the dorsolateral prefrontal cortex and lateral parietal cortex, and is responsible for the maintenance and manipulation of the information in working memory. The EN also plays an important role as support of adaptive, goal-directed behaviors, which is why it is colloquially referred to as "the problem solver." The affective (or salience)