Tegafur/gimeracil/oteracil

The combination drug tegafur/gimeracil/oteracil (trade name Teysuno, and TS-1 in Japan), also known as S-1, is used for the treatment of advanced gastric cancer. It is labelled for use in combination with cisplatin in many European countries, and for head and neck cancer, colorectal cancer, non–small-cell lung, breast, pancreatic, and biliary tract cancers in several countries in Asia. It has not been approved by the FDA.

It is also being developed for the treatment of hepatocellular carcinoma. and has activity in esophageal,(Perry Chapter 33) breast, cervical, and colorectal cancer.

Within the medication, the molar ratio of the three components (tegafur:gimeracil:oteracil) is 1:1:0.4.

The maximum tolerated dose differed between Asian and Caucasian populations (80 mg/m2 and 25 mg/m2 respectively), perhaps due to differences in CYP2A6 genotype.

Mechanism of action
Tegafur is the actual chemotherapeutic agent. It is a prodrug of the active substance fluorouracil (5-FU).

Gimeracil inhibits the degradation of fluorouracil by reversibly blocking the dehydrogenase enzyme dihydropyrimidine dehydrogenase (DPD). This results in higher 5-FU levels and a prolonged half-life of the substance.

Oteracil mainly stays in the gut because of its low permeability, where it reduces the production of 5-FU by blocking the enzyme orotate phosphoribosyltransferase. Lower 5-FU levels in the gut result in a lower gastrointestinal toxicity.


Open Porte du Hainaut

The Open Engie Porte du Hainaut is a tournament for professional female tennis players played on outdoor clay courts. The event is classified as a $25,000 ITF Women's Circuit tournament and has been held in Denain, France, since 1998. The event was previously a $75,000 tournament from 2003 to 2008.

Past finals

Singles

Doubles

External links
 ITF search


Lens-Lestang

Lens-Lestang   is a commune in the Drôme department in southeastern France.

Population


Leptomyrmex

Leptomyrmex, or spider ants, is a genus of ants and a distinctive member of the ant subfamily Dolichoderinae. Commonly known as "spider ants" for their long legs and spider-like movements, these orange and black ants are prominent residents of intact wet forest and sclerophyll habitats throughout their range. One extant species, Leptomyrmex relictus, is known from central Brazil; otherwise, the global distribution of this genus is restricted to eastern Australia, New Caledonia and New Guinea, as well as the nearby Indonesian islands of Aru and Seram.

Newly hatched Extatosoma tiaratum stick insects mimic these ants to avoid predation.

Description
Workers of Leptomyrmex can be easily recognized by elongate antennal scapes which surpass the posterior margin of the head by more than one half their length, a medially notched hypostoma, mandibles with 7–15 teeth and 5–12 denticles, and a laterally located anterior tentorial pit.

Queens are known from only seven species. All known macro-Leptomyrmex queens are wingless (ergatoid). They can be differentiated from workers by the presence of ocelli and their larger size, including
enlarged mesosoma and gaster. Whereas the workers possess a mesosoma that is smooth in profile, the profile of queens is distinctly impressed at the promesonotal suture and the metanotal groove. Appendages are noticeably stouter. Queens of at least one micro-Leptomyrmex species possess wings.

Species groups
The species are informally split into two groups: the macro-Leptomyrmex (21 species), and its sister group, the micro-Leptomyrmex (six species). Macro-Leptomyrmex are large, diurnal and many are conspicuously colored in black, orange or bicolorous black and orange. Micro-Leptomyrmex species have been recently described from Australia, and were placed in Leptomyrmex based on mandibular dentition, anterior clypeal margin configuration, elongate scapes and head, cleft medial hypostomal margin, anterior tentorial pit location, keeled fourth gastral sternite and reduced hind tibial spurs. In some cases, scapes are shorter than in the macro species, and in one species (L. ramorniensis) the hypostoma is only weakly notched. All six species are readily distinguished from their larger congeners by their small size (head width < 0.80mm), brown coloration, relatively short dorsal face of the propodeum, angular (not rounded) petiole and gaster lacking lateral compression. All micro species occur in eastern Australian rainforests.

Micro-Leptomyrmex
Leptomyrmex aitchisoni
Leptomyrmex burwelli
Leptomyrmex dolichoscapus
Leptomyrmex garretti
Leptomyrmex pilosus
Leptomyrmex ramorniensis

Macro-Leptomyrmex
Leptomyrmex cnemidatus
Leptomyrmex darlingtoni
Leptomyrmex erythrocephalus
Leptomyrmex flavitarsus
Leptomyrmex fragilis
Leptomyrmex geniculatus

Leptomyrmex melanoticus
Leptomyrmex mjobergi
†Leptomyrmex neotropicus
Leptomyrmex niger
Leptomyrmex nigriceps
Leptomyrmex nigriventris
Leptomyrmex pallens
Leptomyrmex puberulus

Leptomyrmex rothneyi
Leptomyrmex ruficeps
Leptomyrmex rufipes
Leptomyrmex rufithorax
Leptomyrmex tibialis
Leptomyrmex unicolor
Leptomyrmex varians
Leptomyrmex wiburdi

Evolution

With exception of the South American species Leptomyrmex relictus, the Leptomyrmex species are currently confined to eastern Australia and several nearby Pacific islands. However, the discovery of fossil specimens from the Dominican Republic (20 my) and a supposedly related genus, Leptomyrmula, from Sicily (30 my) led Wilson to describe the evolutionary history of this genus as a "considerable biogeographic anomaly". The assertion that extant species of Leptomyrmex are relicts of a lineage once widespread across the globe that have survived in the tropical refuges of Australasia, is compelling, and similar biogeographic patterns are seen in other so-called "relictual" lineages in Australia, New Guinea and New Caledonia (among them the ant subfamily Myrmeciinae).

The sister group relationship of the winged micro-Leptomyrmex to the wingless macro- clade suggests that the loss of wings may have occurred relatively recently in this lineage, and that stem lineages may not necessarily have been wingless. These observations, in addition to the fact that the sister group of Leptomyrmex (i.e., (Forelius + Dorymyrmex)) also has winged queens, may help explain the proposed widespread former distribution. On the other hand, a recent molecular phylogenetic analysis of the Dolichoderinae places Leptomyrmex firmly within a clade of species (tribe Leptomyrmecini) whose origins appears to be in the Neotropics, with two main dispersal events to Australia. This suggests that the Sicilian fossil Leptomyrmula is not part of this group.


Empire State Games

The Empire State Games are a set of annual Olympic-style competitions for amateur athletes from the state of New York, encompassing several divisions and allowing athletes of all ages to compete.  It was a member of the National Congress of State Games.  The games consisted of a number of competitions:
Summer Games (often referred to as the Empire State Games, typically held in late July)
Winter Games (often referred to as the Empire State Winter Games, typically held in February)
Games for the Physically Challenged (similar to the Paralympics)
Senior Games (specifically for athletes age 50 and older)

In 2009, 2011, 2012 and 2013 the Empire State Summer Games were cancelled.

History

Early history
One of the original organizers of the Empire State Games was Herbert Mols of Buffalo, New York. The first Empire State Games took place at Syracuse University in 1978, the first state games to be held in the United States. The games remained in Syracuse until a delegation from Western New York led by Herbert Mols, Bob Rich, Bob Bedell, Carl Roesch Sr., Dr. Marc Grosso, Gardner Debo, Mark Sternin and Ed Rutkowski brought the Games to Buffalo, New York in 1985 and 1986.

With the success of the first 1978 games, the Empire State Games have sparked the creation of other state games across the country. Before their cancellation, the Empire State Games were the largest state-supported amateur athletic competition in the nation.

The Empire State Games competition was a member of the National Congress of State Games, and was a recognized State Games Program of the United States Olympic Committee.

Cancellations
The 2008 Empire State Games took place from July 23 through July 27, 2008 in Binghamton. The 2009 Empire State Games were cancelled.  In 2010 the games were revived and held from July 21 through July 25, 2010 in Buffalo, New York.

Due to a lack of state funding, the 2011 games were discontinued on November 17, 2010.  The community of Lake Placid was able to save the winter games. As for the Games for the Physically Challenged, they were able to be saved with the help of Nassau County Executive Edward P. Mangano and the partnership with dozens of private sector sponsors.

Return of the games
In 2012 Empire State Sports Foundation (ESSF) was created with the specific goal of rejuvenating the Hugh L. Carey Empire State Games for amateur athletes of New York State. ESSF is a Rochester, New York-based not-for-profit public charity dedicated to the recognition and promotion of competitive excellence among New York State’s amateur athletes, as well as those attributes associated with sports: personal health, fitness, development, education, sportsmanship and teamwork.

The Empire State Summer Games were prepared to return in 2013, but as the ESSF were finding corporate partners, they discovered that corporate sponsors had "been giving any extra funds to Hurricane Sandy relief, leaving little extra room for other worthy causes". The Empire State Games are going to be re-launched in Rochester in the summer of 2014.

Upon hearing that The Empire State Summer Games for 2013 was cancelled Nassau County announced that they will hold the 2013 Games for the Physically Challenged as they have done for the last two years. In an April 2013 press conference, Nassau County Executive Edward P. Mangano stated, "The 2013 Games would not have been able to happen without the genius donation of $50,000 US dollars by NBTY, Inc. through their Helping Hands Charity." Known locally as the Nassau County Empire State Games for the Physically Challenged, the 2013 games took place May 30 through June 1.

End of an era
According to media reports April 2014, the Empire State Sports Foundation (ESSF), a Brighton, New York nonprofit organization whose aim to revive the popular Olympic-style summer sports event fueled hope among amateur athletes and media attention across the state, official announced its intention to disband. According to the official papers that were made public, filed in New York State Supreme Court, show that the foundation is insolvent, owing debts topping $158,000 to multiple creditors.

Regions
New York State is divided into six regions for the Empire State Games, and each region fields its own athletic teams through tryouts before the games begin.

Adirondack Region
Counties: Albany, Clinton, Columbia, Essex, Franklin, Fulton, Greene, Hamilton, Montgomery, Saratoga, Schoharie, Schenectady, St. Lawrence, Rensselaer, Warren, Washington
Cities: Albany, Glens Falls, Plattsburgh, Schenectady, Troy
Uniform color: yellow and blue
Central Region
Counties: Broome, Cayuga, Chemung, Chenango, Cortland, Delaware, Herkimer, Jefferson, Lewis, Madison, Oneida, Onondaga, Oswego, Otsego, Schuyler, Tioga, Tompkins
Cities: Binghamton, Elmira, Ithaca, Oswego, Rome, Syracuse, Utica
Uniform color: light blue and blue
Hudson Valley Region
Counties: Dutchess, Orange, Putnam, Rockland, Sullivan, Ulster,  Westchester
Cities:Yonkers, Mount Vernon, Middletown, Newburgh, Poughkeepsie, White Plains, New Rochelle
Uniform colors: green and yellow
Long Island Region
Counties: Nassau, Suffolk
Uniform colors: gray and red
New York City Region
Counties: Bronx, Kings (Brooklyn), New York (Manhattan), Queens, Richmond (Staten Island)
City: New York City
Uniform color: orange and blue
Western Region
Counties: Allegany, Cattaraugus, Chautauqua, Erie, Genesee, Livingston, Monroe, Niagara, Ontario, Orleans, Seneca, Steuben, Wayne, Wyoming, Yates
Cities: Buffalo, Corning, Niagara Falls,  Rochester
Uniform color: navy blue and red

Summer Games
There are three divisions in the Summer Empire State Games: open, scholastic, and masters. The scholastic division is for New York State residents who are 17 or younger as of August 31 of the year of the games. Some scholastic division sports have a minimum age of 13 years. The open division is for New York State residents who are 18 years of age or older as of August 31 of the year of the games.  The masters division consists of 11 different sports and their age qualifications vary by sport.

Athletic events

Open and scholastic divisions
Open and scholastic events:

 Archery
 Basketball
 Diving
 Fencing

 Gymnastics
 Rowing
 Shooting
 Soccer

 Swimming
 Track and field
 Volleyball
 Wrestling

Open only:

 Boxing
 Bowling
 Cycling

 Canoeing
 Kayaking
 Sailing

 Judo
 Softball
 Weightlifting
 Synchronized swimming

Scholastic only:

 Baseball
 Field hockey

 Ice hockey
 Lacrosse

 Tennis

Masters division

The Masters division competes separately from the open and scholastic divisions, but has many of the same events.

 Archery
 Bowling
 Canoeing
 Cycling

 Diving
 Fencing
 Golf
 Gymnastics

 Rugby
 Swimming
 Volleyball

Host cities

Syracuse played host to the first seven of the games, and in total has hosted the Empire State Games 12 times.  Other cities hosting multiple times include Buffalo (4 times), Albany (3 times), Binghamton (3 times), Rochester (3 times) and Ithaca (2 times).

Winter Games
The Empire State Winter Games are held annually in Lake Placid in the month of February. Most of the events take place at the venues of the 1980 Winter Olympics.

Events

 Alpine skiing
 Snowboarding
 Ski cross
 Boardercross
 Biathlon

 Bobsled
 Cross-country skiing
 Figure skating
 Ice hockey (women only)
 Luge

 Short track speed skating
 Skeleton
 Ski jumping
 Ski orienteering
 Snowshoe racing
 Speed skating

Games for the Physically Challenged

The Empire State Games for the Physically Challenged is open to athletes between the ages of 5 and 21 in the following divisions: visually impaired, blind, hearing impaired, deaf, spinal cord injury, amputee, cerebral palsy, and les autres (which includes conditions such as muscular dystrophy, dwarfism, and arthritis, among others).

Events

 Adapted Games
 Archery
 Slalom obstacle course

 Swimming
 Table tennis
 Track and field

 Wheelchair racing
 Wheelchair Basketball

Senior Games
The Empire State Senior Games is an organized sports competition and leisure program for those age 50 and older which: Provides recreational opportunities. Encourages fitness as a lifelong activity. Promotes the positive image of seniors. Combines sports and games with fitness, fun and fellowship. Advocates true competition in its purest form.

Events

 Archery
 Badminton
 Basketball
 Bridge
 Cycling
 Disc Golf
 Golf - Long course (par 71)
 Golf - Short course (par 54)

 Horseshoes
 Orienteering
 Pickleball
 Ping Pong (Table Tennis)
 Race Walk (5K)
 Racquetball
 Road Race (5K)
 Road Race (10K)

 Shuffleboard
 Softball
 Swimming
 Tennis
 Track & Field
 Triathlon
 Volleyball

Notable Empire State Games athletes

 Alpine skiing
 Diann Roffe, Western
 Jes Sauereisen, Holiday Valley (ski resort)
 Nathan Briselden, Holiday Valley (ski resort)

 Baseball
 Andy Van Slyke, Central

 Basketball
 Kenny Anderson, New York City
 Ron Artest, New York City, 1997–1998
 Walter Berry, New York City
 Sue Bird, Long Island
 Elton Brand, Hudson Valley, 1997
 Rick Carlisle, Adirondack
 Christian Laettner, Western
 Chris Mullin, New York City
 Sam Perkins, New York City
 Wally Szczerbiak, Long Island, 1997
 Dwayne Washington, New York City

Boxing
 Michael Bentt, New York City
 Hector Camacho, New York City
 Joe Mesi, Western
 Mike Tyson, New York City
 Hasim Rahman

Cycling
 Mike McCarthy, New York City
 George Hincapie, Long Island

Fencing
 Glen Moore, Western

Field hockey
 Tracey Fuchs, Long Island

Ice hockey
 Christopher Higgins, Long Island, 2000–2001
 Todd Marchant, Western
 Matt Murley, Central, 1997
 Vincent Tozzo, Hudson Valley, 1999-2000
 Rob Schremp, Central, 2000
 Dustin Brown, Central, 2000
 Lyndsay Wall, Western, 2001
 Stephen Gionta, Western
 Josephine Pucci, Hudson Valley
 Colin Reilly, Hudson Valley, 2010
 Mike Marnell, Long Island, 2010
 Jimmy Mazza, Long Island, 2010

Lacrosse
 JonJon Castro, Long Island, 1995
 Matthew Landis, Hudson Valley, 2010

Shooting
 Sandra Fong, Long Island
 Thrine Kane, Long Island
 Jimmie Perrin, Western, 1995–2010
 Jason Turner, Western
 Thomas White, Hudson Valley, 1978–2010

  Skeleton
 Jimmy Shea, Adirondack
 Gary Wozniak, Los Gatos, CA

 Soccer
 Abby Wambach, Western
 Jerrod Laventure, Long Island

 Swimming
 Kara Lynn Joyce, Western

 Wrestling
 Jeff Blatnick, Adirondack

Gymnastics John Orosco, New York City


Mary Prince

Mary Prince (c. 1 October 1788 – after 1833) was a British abolitionist and autobiographer, born in Bermuda to an enslaved family of African descent. Subsequent to her escape, when she was living in London, England, she wrote her slave narrative The History of Mary Prince (1831), which was the first account of the life of a black woman to be published in the United Kingdom. This first-hand description of the brutalities of enslavement, released at a time when slavery was still legal in Bermuda and British Caribbean colonies, had a galvanising effect on the anti-slavery movement. It was reprinted twice in its first year.

Prince had her account transcribed while living and working in England at the home of Thomas Pringle, a founder of the Anti-Slavery Society. She had gone to London with her master and his family in 1828 from Antigua.

Early life and education
Mary Prince was born into enslavement at Brackish Pond in Bermuda, known today as Devonshire Parish, Bermuda. Her father (whose only given name was Prince) was a sawyer owned by David Trimmingham, and her mother a house-servant held by Charles Myners. She had three younger brothers and two sisters, Hannah and Dinah. When Myners died in 1788, Mary Prince, her mother and siblings were sold as household servants to Captain Darrell. He gave Mary and her mother to his daughter, with Mary becoming the companion servant of his young granddaughter, Betsey Williams.

At the age of 12, Mary was sold for £38 sterling (Present day: ~£4484) to Captain John Ingham, of Spanish Point. Her two sisters were also sold that same day, all to different enslavers. Mary's new enslaver and his wife were cruel and often lost their tempers, Mary and others were often severely flogged for minor offences.

Ingham sold Mary in 1806 to an enslaver on Grand Turk in The Turks and Caicos Islands, who owned salt ponds. The Bermudians had used these seasonally for a century for the extraction of salt from the ocean. The production of salt for export was a pillar of the Bermudian economy, but the production was labour-intensive. Originally, raking had been performed by whites due to the fear of black enslaved people being seized by Spanish and French raiders (the enslaved were considered property, and could be seized as such during hostilities). Blacks crewed the Bermuda sloops that delivered the rakers to and from the Turks Islands and delivered salt to markets in North America, engaging in maritime activities while the whites raked. When the threats posed by the Spanish and French in the region decreased, however, the enslaved were put to work in the salt pans.

As a child Mary worked in poor conditions in the salt ponds up to her knees in water. Due to the nature of salt mining, Mary and others were often forced to work up to 17 hours straight as owners of the ponds were concerned that if the workers were gone for too long rain would come and soil the salt. Generally, men were the salt rakers, forced to work in the salt ponds, where they were exposed to the sun and heat, as well as the salt in the pans, which ate away at their uncovered legs. Women did packaging of salt.

Mary Prince was returned to Bermuda in 1810, where her master at the time had moved with his daughter. While here, she was physically abused by her master, and forced to bathe him under threat of further beatings. Mary resisted her master's abuse on two occasions: once, in defence of his daughter, whom he also beat; the second time, defending herself from her master when he beat her for dropping kitchen utensils. After this, she left his direct service and was hired out to Cedar Hill for a time, where she earned money for her master by washing clothes.

In 1815, Mary was sold a fourth time, to John Adams Wood of Antigua for $300 (2017: ~$4600). She worked in his household as a domestic slave, attending the bedchambers, nursing a young child, and washing clothes. There she began to suffer from rheumatism, which left her unable to work. When Adams Wood was traveling, Mary earned money for herself by taking in washing and by selling coffee, yams and other provisions to ships.

In Antigua, she joined the Moravian Church, where she also attended classes and learned to read. She was baptised in the English church in 1817 and accepted for communion, but she was afraid to ask Adams Wood for permission to attend. In December 1826, Prince married Daniel James, a formerly enslaved man who had bought his freedom by saving money from his work. He worked as a carpenter and cooper. According to Mary, her floggings increased after her marriage because Adams Wood and his wife did not want a free black man living on their property.

Travel to England
In 1828 Adams Wood and his family travelled to London, visiting and arranging their son's education, and to bring their daughters home to the islands. At her request, they took Mary Prince with them as a servant. After the case of Somerset v Stewart in 1772, it was ruled that it was illegal to transport slaves out of England. That, however, did not make slavery illegal in England, even though public opinion believed it did. Even if she could leave the Adam Wood's household, however, she had no means to support herself alone in England. Additionally, unless Wood formally emancipated her, she could not return to her husband in Antigua without being re-enslaved there.

Although she had served the Woods for more than ten years, they had increasing conflict in England. Four times Wood told her to obey or leave. They gave her a letter that nominally gave her the right to leave but suggested that no one should hire her.

After leaving the household, Prince took shelter with the Moravian church in Hatton Garden. Within a few weeks, she started working occasionally for Thomas Pringle, an abolitionist writer, and Secretary to the Anti-Slavery Society, which offered assistance to blacks in need. Prince found work with the Forsyth household, but the couple moved away from England in 1829. The Woods also left England in 1829 and returned with their daughter to Antigua. Pringle tried to arrange to have Wood manumit Prince, so she would have legal freedom.

In 1829 Adams Wood refused either to manumit Mary Prince or allow her to be purchased out of his control. His refusal to sell or free her meant that as long as slavery remained legal in Antigua, Prince could not return to her husband and friends without being re-enslaved and submitting to Wood's power. After trying to arrange a compromise, the Anti-Slavery Committee proposed to petition Parliament to grant Prince's manumission, but did not succeed. At the same time, a bill was introduced to free all slaves from the West Indies in England whose owners had freely brought them there; it did not pass but was an indication of growing anti-slavery sentiment.

Publication of The History of Mary Prince
In December 1829, Pringle hired Prince to work in his own household. Encouraged by Pringle, Prince arranged for her life narrative to be transcribed by Susanna Strickland. Pringle served as editor, and her book was published in 1831 as The History of Mary Prince. The book caused a commotion as it was the first account published in Great Britain of a black woman's life; at a time when anti-slavery agitation was growing, her first person account touched many people. In the first year, it sold out three printings.

Two libel cases arose out of it, and Prince was called to testify at each.

Prince's life after her book was published is not much known. It is not clear whether she ever returned to Antigua and her husband as she had wished.

She is known to have remained in England until at least 1833, when she testified in the two libel cases. That year, the Slavery Abolition Act was passed, to be effective August 1834. In 1808, Parliament had passed the Slave Trade Act of 1807, which outlawed the slave trade but not slavery itself. The 1833 law was intended to achieve a two-staged abolition of West Indian slavery by 1840, allowing the colonies time to transition their economies. Because of popular protests in the West Indies among the freedmen, the colonies legally completed abolition two years early in 1838. In Bermuda, which was not dependent on the institution of slavery, emancipation took place immediately on the law going into effect in 1834. If Prince was still alive and in good health, she may then have returned as a free woman to her homeland.

The book and its influence
When Prince's book was published, slavery was still legal in England, and had not been abolished by the 1772 Somerset v Stewart ruling, as previously believed by some historians. Parliament had also not yet abolished it in the colonies. There was considerable uncertainty about the political and economic repercussions that might arise if Britain imposed an end to slavery throughout the empire, as the sugar colonies depended on it for labour to raise their lucrative commodity crop. As a personal account, the book contributed to the debate in a manner different from reasoned analysis or statistical arguments. Its tone was direct and authentic, and its simple but vivid prose contrasted with the more laboured literary style of the day.

An example is Prince's description of being sold away from her mother at a young age:

It was night when I reached my new home. The house was large, and built at the bottom of a very high hill; but I could not see much of it that night. I saw too much of it afterwards. The stones and the timber were the best things in it; they were not so hard as the hearts of the owners.

Prince wrote of slavery with the authority of personal experience, something her political opponents could never match.
She wrote:

I have been a slave myself—I know what slaves feel—I can tell by myself what other slaves feel, and by what they have told me. The man that says slaves be quite happy in slavery—that they don't want to be free—that man is either ignorant or a lying person. I never heard a slave say so. I never heard a Buckra (white) man say so, till I heard tell of it in England.

Her book had an immediate effect on public opinion and was published in three impressions the first year. It generated controversy, and James MacQueen, the editor of The Glasgow Courier, challenged its accuracy by a lengthy letter in Blackwood's Magazine.  MacQueen was a defender of white West Indian interests and vigorous critic of the anti-slavery movement.  He depicted Prince as a woman of low morals who had been the "despicable tool" of the anti-slavery clique, who had incited her to malign her "generous and indulgent owners."  He attacked the character of the Pringle family, suggesting they were at fault for accepting the slave in their household.

In 1833 Pringle sued MacQueen for libel, receiving damages of £5.  Not long afterwards, John Wood, Prince's master, sued Pringle for libel, holding him responsible as the editor of Prince's The History, and claiming the book generally misrepresented his character.  Wood won his case and was awarded £25 in damages.  Prince was called to testify in both these trials, but little is known of her life after this.

Legacy
On 26 October 2007, a commemorative plaque organised by the Nubian Jak Community Trust was unveiled in Bloomsbury, where Mary Prince once lived.
Also in 2007, the Museum in Docklands opened a new gallery and permanent exhibition entitled London, Sugar & Slavery, which credits Prince as an author who "played a crucial role in the abolition campaign".

Representations in other media
Prince is featured as the fictional love interest in the jazz opera Bridgetower – A Fable of 1807 (2007), by Julian Joseph with libretto by Mike Phillips, about the 18th-century black violinist George Bridgetower.
In the UK and Republic of Ireland, and in parts of Europe and South America, Prince was the subject of a Google doodle on Monday 1 October 2018 to mark her 230th birthday.


TLR9

Toll-like receptor 9 is a protein that in humans is encoded by the TLR9 gene. TLR9 has also been designated as CD289 (cluster of differentiation 289). It is a member of the toll-like receptor (TLR) family. TLR9 is an important receptor expressed in immune system cells including dendritic cells, macrophages, natural killer cells, and other antigen presenting cells. TLR9 preferentially binds DNA present in bacteria and viruses, and triggers signaling cascades that lead to a pro-inflammatory cytokine response. Cancer, infection, and tissue damage can all modulate TLR9 expression and activation. TLR9 is also an important factor in autoimmune diseases, and there is active research into synthetic TLR9 agonists and antagonists that help regulate autoimmune inflammation.

Function

The TLR family plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are named for the high degree of conservation in structure and function seen between mammalian TLRs and the Drosophila transmembrane protein Toll. TLRs are transmembrane proteins, expressed on the cell surface and the endocytic compartment and recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and initiate signalling to induce production of cytokines necessary for the innate immunity and subsequent adaptive immunity. The various TLRs exhibit different patterns of expression.

This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and humans indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.

TLR9 is usually activated by unmethylated CpG sequences in DNA molecules. Once activated, TLR9 moves from the endoplasmic reticulum to the Golgi apparatus and lysosomes, where it interacts with MyD88, the primary protein in its signaling pathway. TLR9 is cleaved at this stage to avoid whole protein expression on cell surface, which could lead to autoimmunity. CpG sites are relatively rare (~1%) on vertebrate genomes in comparison to bacterial genomes or viral DNA.  TLR9 is expressed by numerous cells of the immune system such as B lymphocytes, monocytes, natural killer (NK) cells, keratinocytes, melanocytes, and plasmacytoid dendritic cells. TLR9 is expressed intracellularly, within the endosomal compartments and functions to alert the immune system of viral and bacterial infections by binding to DNA rich in CpG motifs. TLR9 signals leads to activation of the cells initiating pro-inflammatory reactions that result in the production of cytokines such as type-I interferon, IL-6, TNF and IL-12. There is also recent evidence that TLR9 can recognize nucleotides other than unmethylated CpG present in bacterial or viral genomes. TLR9 has been shown to recognized DNA:RNA hybrids, but not ssDNA.

Role in non-viral cancer
TLR9 expression progression during cancer varies greatly with the type of cancer. TLR9 may even present an exciting new marker for many cancer types. Breast cancer and renal cell carcinoma have both been shown to diminish expression of TLR9. In these cases higher levels correspond with better outcomes. Conversely studies have shown higher levels of TLR9 expression in breast cancer and ovarian cancer patients, and poor prognosis is associated with higher TLR9 expression in prostate cancer. Non-small cell lung cancer and glioma have also been shown to up-regulate the expression of TLR9. While these results are highly variable, it is clear that TLR9 expression increases the capacity for invasion and proliferation. Whether cancer induces modification of TLR9 expression or TLR9 expression hastens the onset of cancer is unclear, but many of the mechanisms that regulate cancer development also play a role in TLR9 expression. DNA damage and the p53 pathway influence TLR9 expression, and the hypoxic environment of tumor cells certainly induces expression of TLR9, further increases proliferation ability of the cancerous cells. Cellular stress has also been shown to relate to TLR9 expression. It is possible that cancer and TLR9 have a feed-forward relationship, where the occurrence of one leads to the up-regulation of the other. Many viruses take advantage of this relationship by inducing certain TLR9 expression patterns to first infect the cell (down-regulate) then trigger the onset of cancer (up-regulate).

Expression in oncogenic viral infection

Human papilloma virus (HPV)
Human papilloma virus is a common and widespread disease that, if left untreated, can lead to epithelial lesions and cervical cancer. HPV infection inhibits the expression of TLR9 in keratinocytes, abolishing the production of IL-8. However inhibition of TLR9 by oncogenic viruses is temporary, and patients with long-lasting HPV actually show higher levels of TLR9 expression in cervical cells. In fact, the increase in expression is so severe that TLR9 could be used as a biomarker for cervical cancer. The relationship between HPV-induced epithelial lesion, cancer progression, and TLR9 expression is still under investigation.

Hepatitis B virus (HBV)
Hepatitis B virus down-regulates the expression of TLR9 in pDCs and B cells, destroying the production of IFNα and IL-6. However, just as in HPV, as the disease progresses TLR9 expression is up-regulated. HBV induces an oncogenic transformation, which leads to a hypoxic cellular environment. This environment causes the release of mitochondrial DNA, which has CpG regions that can bind to TLR9. This induces over-expression of TLR9 in tumor cells, contrary to the inhibitory early stages of infection.

Epstein-Barr virus (EBV)
Epstein-Barr virus, like other oncogenic viruses, decreases the expression of TLR9 in B cells, diminishing production of TNF and IL-6. EBV has been reported to alter expression of TLR9 at the transcription, translation, and protein level.

Polyomavirus
The viruses of the polyomavirus family destroy expression of TLR9 in keratinocytes, inhibiting the release of IL-6 and IL-8. Expression is regulated at the promoter, where antigen proteins inhibit transcription. Similar to HPV and HBV infection, TLR9 expression increases as the disease progresses, probably due to the hypoxic nature of the solid tumor environment.

Clinical relevance of inflammation response
TLR9 has been identified as a major player in systemic lupus erythematosus (SLE) and erythema nodosum leprosum (ENL). Loss of TLR9 exacerbates progression of SLE, and leads to increased activation of dentritic cells. TLR9 also controls the release of IgA and IFN-a in SLE, and loss of the receptor leads to higher levels of both molecules. In SLE, TLR9 and TLR7 have opposing effects. TLR9 regulates inflammatory response, while TLR7 promotes inflammatory response. TLR9 has an opposite effect in ENL. TLR9 is expressed at high levels on monocytes of ENL patients, and is positively linked to the secretion of proinflammatory cytokines TNF, IL-6, and IL-1β. TLR9 agonists and antagonists may be useful in treatment of a variety of inflammatory conditions, and research in this area is active. Autoimmune thyroid diseases have also been shown to correlate with an increase in expression of TLR9 on peripheral blood mononuclear cells (PBMCs). Patients with autoimmune thyroid diseases also have higher levels of the nuclear protein HMGB1 and RAGE protein, which together act as a ligand for TLR9. HMGB1 is released from lysed or damaged cells. HMGB1-DNA complex then binds to RAGE, and activates TLR9. TLR9 can work through MyD88, an adaptor molecule that increases the expression of NF-kB. However autoimmune thyroid diseases also increase sensitivity of MyD88 independent pathways. These pathway ultimately leads to the production of pro-inflammatory cytokines in PMBCs for patients with autoimmune thyroid diseases. Autoimmune diseases can also be triggered by activated cells undergoing apoptosis and being engulfed by antigen presenting cells. Activation of cells leads to de-methylation, which exposes CpG regions of host DNA, allowing an inflammatory response to be activated through TLR9. Although it is possible that TLR9 also recognizes unmethylated DNA, TLR9 undoubtedly has a role in phagocytosis-induced autoimmunity.

Role in heart health
Inflammatory responses mediated by TLR9 pathways can be activated by unmethylated CpG sequences that exist within human mitochondrial DNA. Usually, damaged mitochondria are digested via autophagy in cardiomyocytes, and mitochondrial DNA is digested by the enzyme DNase II. However mitochondria that escape digestion via the lysosome/autophagy pathway can activate TLR9-induced inflammation via the NF-kB pathway. TLR9 expression in hearts with pressure overload leads to increased inflammation due to damaged mitochondria and activation of the CpG binding cite on TLR9.

There is evidence that TLR9 may play a role in heart heath for individuals who have already suffered a myocardial infarction. In murine trials, TLR9-deficient mice had less myofibroblast proliferation, meaning cardiac muscle recovery is connected to TLR9 expression. Furthermore, class B CpG sequences induce proliferation and differentiation of fibroblasts via the NF-kB pathway, the same pathway that initiates pro-inflammatory reactions in the immune responses. TLR9 shows specific activity in post-heart attack fibroblasts, inducing them to differentiate into myofibroblasts and speed repair of left ventricle tissue. In contrast to pre-myocardial infarction, cardiomyocytes in recovering hearts do not induce an inflammation response via TLR9/NF-kB pathway. Instead, the pathway leads to proliferation and differentiation of fibroblasts.

As an immunotherapy target

There are new immunomodulatory treatments undergoing testing which involve the administration of artificial DNA oligonucleotides containing the CpG motif. CpG DNA has applications in treating allergies such as asthma, immunostimulation against cancer,  immunostimulation against pathogens, and as adjuvants in vaccines.

TLR9 agonists
 Lefitolimod (MGN1703) has started clinical trials to treat (in combination with ipilimumab) patients with advanced solid malignancies.
 Ongoing studies are investigating SD-101 (Dynavax) in combination with Keytruda (pembrolizumab), an anti-PD-1 therapy developed by Merck.
 A Phase 1/2 trial is ongoing with tilsotolimod (IMO-2125, Idera, NASDAQ:IDRA) in combination with Yervoy (ipilimumab), an anti-CTLA-4 therapy developed by Bristol-Myers Squibb in anti-PD-1 refractory melanoma patients. FDA also granted fast track designation for tilsotolimod in combination with ipilimumab for treatment of PD-1 refractory metastatic melanoma. A phase 3 global trial in the same population is currently enrolling (Illuminate 301, NCT03445533).

Protein interactions

 TLR9 has been shown to interact with RNF216.
Epidermal growth factor receptor (EGFR) is constitutively bound to TLR9.
 It can be activated by CpG Oligodeoxynucleotides such as Agatolimod.


Mount Leinster

Mount Leinster () is a  mountain in the Republic of Ireland. It straddles the border between Counties Carlow and Wexford, in the province of Leinster. It is the fifth-highest mountain in Leinster after Lugnaquilla 925m, Mullaghcleevaun 849m, Tonelagee 817m, and Cloghernagh 800m, and the highest of the Blackstairs Mountains. A 2RN transmission site tops the peak with a mast height of 122 m.

Summit access
The mountain is most often climbed from the Nine Stones, a landmark point at the foot of Mount Leinster, about 8 miles east of Borris. From Borris there is a road to a visitor car park on the mountain. From there the steep 2RN access road leads to the summit. This road is closed to normal traffic and 2RN have now fenced off the transmitter mast from public access to prevent vandalism.

The Nine Stones and the car park lie on the saddle between Mount Leinster and the nearby Slievebawn (Sliabh Bán; 52°38′18.6″N 6°48′33.32″W; 520m). There are in fact ten stones. They are arranged in a line and the largest is about 50 cm high. The origin of the stones is uncertain.

Other sports

Cycling
Mount Leinster has been used in stages of the Tour of Ireland and on many occasions in the FBD Insurance Rás (Rás Tailteann). It may be climbed from the Borris side in County Carlow or the Bunclody side in County Wexford. Ascending from Borris the climb is 11 km long and has an average gradient of 6.9%. The last two kilometres are very tough reaching a gradient of almost 16%. Although the climb from Bunclody is slightly longer at 13 km its average gradient is 5.9%. The last kilometre of this climb is difficult with a gradient of 16.3%. The mountain is also used by The ML Syndicate (mountain biking club) who use the area for trail riding and MTB sporting events .

Hang gliding
The transmission site is a popular launch location for hang gliding and for radio-controlled gliders. In 2003, a hang glider pilot died from injuries sustained in the crash landing of his flight launched from the mountain. There is a memorial at the peak of the mountain.

Plane Crash

On Wednesday 7 September 1983 a Cessna 182Q Skylane light aircraft crashed 30 m below the summit while on a flight from Birmingham to Kilkenny. The four people aboard all died.

Transmission site
The Mount Leinster transmitter is owned and operated by 2RN and at 796m ASL it is the highest transmission site in Ireland. It was one of the original five main Telefís Éireann television transmitters when it opened on low power in December 1962. It became fully operational on 12 June 1963 with a 625-line service on VHF Band III Channel F. The new RTÉ Radio FM service was added in 1966, and RTÉ's second television channel RTÉ 2 was carried on VHF when it started in 1978. UHF television transmissions from Mount Leinster began in 1996 with the introduction of Teilifís na Gaeilge. The original 1962 mast was replaced in 2010 with a taller one of 122m in preparation for digital television transmissions. In common with all the other 2RN sites, analogue television transmissions from Mount Leinster ceased on 24 October 2012.
Today the site provides the Irish digital television service Saorview, and eight FM radio stations to a large area of South East Ireland.

Current transmissions

Digital television

FM radio

Relay

Relay transmitters that rebroadcast digital television from Mount Leinster:


Jannie de Groot

Adriana Elisabeth "Jannie" de Groot (also Janny; born 4 January 1930) is a retired Dutch swimmer. In 1947 and 1950 she won the national titles and became third in the 200 m breaststroke at the European Aquatics Championships. She competed in the same event at the 1948 Summer Olympics and finished fifth in the final won by Dutch teammate Nel van Vliet. Jannie's brother, Daan de Groot (1933–1982), was an Olympic cyclist.


Khunga, Panchthar

Khunga is a village development committee in Panchthar District in the Mechi Zone of eastern Nepal. At the time of the 1991 Nepal census it had a population of 2287 people living in 397 individual households.


Formula König

Formula König was an open wheel racing series based in Germany and sponsored by German automobile company König Komfort- und Rennsitze GmbH (König comfort and racing seats GmbH). It ran from 1988 to 2004 as a single-seater feeder series. Its most famous champion was seven-time Formula One world champion, Michael Schumacher.

Scoring system

Champions


Verix

Verix is a business intelligence software company headquartered in San Jose, California.  Founded in 2007, Verix delivers AI-driven analytic solutions for Sales and Marketing teams, focusing on the Pharma and Consumer Packaged Goods (CPG) industries.

Verix’s business intelligence software runs either as Software as a Service or on-site on the customer’s servers.  The software integrates with existing business intelligence programs and company data warehouses. Verix solutions are used by sales, marketing and business development departments in identifying areas of the business that need improvement through business intelligence analytics.

Verix developed a proprietary technology for ETL and data analysis based on the statistical, mathematical, machine learning, and bioinformatics fields. Large amounts of data from both internal and external data sources are analyzed, and algorithms applied to identify outliers, statistically significant anomalies, in the intersections between data sets.  Verix performs automatic segmentation of the detected exceptions, known as Intelligent Business Alerts (Hotspots), then analyzes the business drivers attributed to the phenomena. Verix users are alerted to the Hotspots and probable causes, and can use the software to investigate further and make business decisions.

The data storage and access of Verix is Oracle-based, and the application server uses JBoss and J2EE.  The analysis server is Java-based.

Verix clients include P&G, Bayer, Roche and DSI.

HotSpots
"Intelligent Business Alerts (IBA), also known as "HotSpots", are terms coined by Verix to describe statistically significant anomalies in business data. HotSpots are revealed through analysis algorithms of business data using the Patent Pending Verix IBA technology.   HotSpots reveal changes in business performance metrics and trend breaks. They provide points of focus in Verix’s BI analysis as they contain particular potential for increasing business success or preventing business harm.

Hotspots are identified by analyzing very large sets of external and internal sources of business data to discover statistically significant anomalies in the trend patterns, taking into account historical data and performance along with up-to-date data. The anomalies are analyzed to determine common characteristics and condense multiple exceptional points into noteworthy, business-relevant alerts. Analysis is then performed to identify potential causes for the exceptions. Alerts are categorized according to their application to the business, and delivered to users as actionable, categorized alerts. Hotspots facilitate a style of business management termed Management by Exception (MBE).

Hotspots are a purely data-driven alert system, without need for external input in the form of queries and rules to identify relevant alerts. The system is scalable and can manage data sets ranging from small to huge. The analysis algorithms were developed based on the Statistical, Mathematical, Machine Learning, and Bioinformatics fields.


Indus Basin Project

The Indus Basin Project is a water control project that resulted from a treaty, Indus Waters Treaty, signed between India and Pakistan in 1960 that guaranteed that Pakistan would receive water from the Indus River independent from upstream control by India.

Indus Water Treaty (IWT) restrains both (India) and lower (Pakistan) riparian from pulling out of accord from fear of deadly consequences. IWT is founded on World Bank’s professionally prepared com-prehensive terms and conditions keeping in mind future regional developments. This treaty has given control of three eastern rivers (Ravi, Beas and Sutlej) to India and three western rivers (Indus, Jhelum and Chenab) to Pakistan. Upper riparian diverted 34 million acre feet (MAF) water out of eastern rivers before entering into Pakistan and launched run-of-river power plants spree on western rivers in last two decades. Restricting water flow to lower riparian in the name of pond filling needs attention. Unrestricted use of water in run-of-river power plants is pointed out to be a limiting factor in Indus Water Treaty. Continuum of cooperation has room for collaboration under Indus Water Treaty. India and Pakistan can sort out disputes by dialogue, in light of rights and needs, rather Harmon Doctrine.

The project consisted of the construction of two main dams, the Mangla Dam built  on the Jhelum River and the Tarbela Dam constructed on the Indus River, together with their subsidiary dams.

Notes


Adesmus clathratus

Adesmus clathratus is a species of beetle in the family Cerambycidae. It was described by Johannes von Nepomuk Franz Xaver Gistel in 1848. It is known from Brazil.


White Tiger (Izzy Bizu song)

"White Tiger" is a 2015 song by English soul singer Izzy Bizu from the album A Moment of Madness.

It was featured in a 2018 commercial for Cacharel.

Track listing

Charts


Roy Grounds House

The Roy Grounds House, at 24 Hill Street, Toorak in Melbourne, Australia, was designed by Sir Roy Grounds as his own home for his wife Betty and himself. It is celebrated as one of the most outstanding works of modernist domestic architecture of the mid 20th century in Victoria, a time of great experimentation, and one of the most notable designs by Roy Grounds, one of the most well known and influential modern architects in Victoria.

Description
The house is an exercise in pure platonic geometries in plan, a perfectly circular glass walled courtyard within a square of solid brick walls, broken only by the front door (and a back door to the kitchen). A broad flat roof with wide eaves floats above the external wall on continuous highlight windows. Internally the rooms are divided by radial walls, which stop short of the courtyard, the focus of the house.

There are four flats behind the house that reach down the block, the first being a smaller single level studio unit, while the other three are matching larger double storey two bedroom units. These three step towards the driveway, allowing easy access to undercover parking, and increasingly larger courtyard gardens. While they do not have the geometry or oriental repose of the main house, they include distinctive features such as the angled carport walls, small slatted balconies, and a double height main space, with double storey window wall facing the courtyard gardens.

Significance
The complete focus on the internal courtyard, creates an inward looking, almost eastern character. This oriental influence continues to the external design, with strong solid walls, topped by projecting eaves floating above the highlight windows, and a single central large door with oversized knocker. The original planting of the courtyard with persimmon and bamboo also displays an eastern influence.

The house is one of series by Roy Grounds built in the same year that explored pure geometric shapes; this house was square, the Henty House in Frankston was circular, while the Leyser House in Kew was an elevated triangle.

The Roy Grounds House is one of the most well known Mid Century Modernist houses in Melbourne. It received the only award granted in 1954, the Victorian Architecture Medal, which in turn was the only award granted between the awards ceasing in 1942 and restarting in 1964. in 1989 it was one of about 30 houses representing the range of Victorian house styles that were featured as models in the exhibition 'Home Sweet Home: Changes in Victorian Domestic Architecture, 1839-1989' staged by the Royal Australian Institute of Architects and the Museum of Victoria in 1989. In 2001 it was added to the Victorian Heritage Register. The house is considered a prototype for Grounds' design for the National Gallery of Victoria (NGV) in 1959, which also features a rectangular masonry volume, central door, highlight windows with a floating roof, and central courtyards. Since the mid 2000s the house has been rediscovered and elements restored, and is a widely known and celebrated, with owners passionate about its significance.

Gallery

Footnotes

External links
 Collection of architectural drawings for the architects own courtyard house at 24 Hill Street Toorak and four adjoining flats by Roy Grounds, Roy Grounds,Roy Burman Grounds Sir 1905-1981, State Library of Victoria. Found here
Australian Dictionary of Biography entry for Roy Grounds
List of works in Canberra by Canberra House here
 Australian Institute of Architects assessment Grounds House and Flats
Model of house in Museums Victoria collection Architectural Model - Grounds House, Toorak, 1952-1953


Lasioglossum carinifrons

Lasioglossum carinifrons, also known as the Lasioglossum (Evylaeus) carinifrons, is a species of bee in the genus Lasioglossum, of the family Halictidae.


It Had to Be You: The Great American Songbook is the first album of American pop standards recorded by British musician Rod Stewart. It was released on 22 October 2002, and became the first in a five-volume series.

The album was Stewart's first release for Sony Music imprint J Records. It included his second recording of "Every Time We Say Goodbye."

A live DVD of the same title was released on 4 February 2003, which featured performances of material from the studio album as well as Stewart's earlier material.

Track listing

Personnel

 Rod Stewart – lead vocals
 Will Hollis – piano (1, 2), synthesizer (2), string synthesizer and solo arrangements (2), vibraphone (3)
 Renato Neto – piano (1), string synthesizer (1), arrangements (1), synthesizer, flute (13)
 Randy Kerber – piano (3, 7, 13), synthesizer (3, 7, 13)
 Andrew Chukerman – synthesizer (3, 7, 10, 13)
 Rob Mounsey – keyboards (4, 5, 8), piano (4, 5), rhythm arrangements and conductor (4)
 Philippe Saisse – keyboards (4, 5, 6, 8, 9, 10, 12, 14), orchestra arrangements and conductor (5, 8, 12)
 Russ Kassoff – piano (8, 10, 12, 14)
 Lee Musiker – piano intro (9)
 Randy Waldman – piano (11)
 Jim Fox – guitar (1)
 Jimmy Rip – guitar (1, 2)
 Bob Mann – guitar (3, 7, 13), arrangements (3, 7, 13), guitar solo (7)
 Jeff Mironov – guitar (4, 5, 6, 8, 9, 10, 12, 14), guitar solo (14)
 Dennis Budimir – guitar (11)
 Dave Carpenter – bass guitar (1)
 Reggie McBride – bass guitar (2)
 Bob Magnusson – bass guitar (3, 7, 13)
 David Finck – bass guitar (4, 5, 6, 8, 9, 10, 12, 14)
 Tal Bergman – drums (1), drum programming (1, 11), arrangements (1),  percussion (7)
 John Ferraro – drums (2), percussion (7)
 Allan Schwartzberg – drums (3, 7, 13)
 Shawn Pelton – drums (4, 5, 6, 8, 9, 10, 12, 14)
 Harvey Mason – drums (11)
 Dan Higgins – clarinet solo (1), alto saxophone solo (2)
 Michael Brecker – tenor saxophone solo (4)
 Dave Koz – tenor saxophone solo (6, 10)
 Arturo Sandoval – trumpet solo (5), flugelhorn solo (8)
 Chris Botti – trumpet solo (13)
 Richard Perry – arrangements (1), basic track arrangement (2)
 Don Sebesky – orchestra arrangements and conductor (4, 8, 12), rhythm arrangements and conductor (4, 8, 12), arrangements and conductor (9), piano (9)
 Doug Katsaros – rhythm arrangements (5), arrangements and conductor (6, 10, 14), acoustic piano (6)
 Jeremy Lubbock – string arrangements and conductor (11), woodwind arrangements and conductor (11)

Production
 Producers – Richard Perry (Tracks 1, 2, 3, 7, 11 & 13); Phil Ramone (Tracks 4, 5, 6, 8, 9, 10, 12 & 14).
 Associate Producers on Track 1 – Tal Bergman and Renato Neto
 Vocal production on Track 11 – Phil Ramone
 Executive Producer – Clive Davis
 A&R – Keith Naftaly
 Production Coordination on Tracks 1, 2, 3, 7, 11 & 13 – Ben McCarthy
 Music Consultant on Tracks 1, 2, 3, 7, 11 & 13 –  Daphna Kaster
 Production Manager and Music Contractor on Tracks 4, 5, 6, 8, 9, 10, 12 & 14 – Jill Dell'Abate
 Recording Engineers – Mark Valentine (Track 1); Carter Humphrey (Tracks 2 & 3); Jeff "Woody" Woodruff (Tracks 2, 3, 7, 11 & 13); Frank Filipetti (Tracks 4, 5, 6, 8, 9, 10, 12 & 14).
 Additional Engineering and Pro Tools Technicians on Tracks 1, 2, 3, 7, 11 & 13 – J.J. Blair, Brian Cook, Steve Deutsch, Alex Gibson, Bobby Ginsberg, Johnny Kubelka and Trent Slatton.
 Additional Engineering on Tracks 4, 5, 6, 8, 9, 10, 12 & 14 – Joel Moss, Freddy Pinero, Chris Steinmetz and Jeff "Woody" Woodruff.
 Assistant Engineers on Tracks 4, 5, 6, 8, 9, 10, 12 & 14 – Wade Childers, Brian Dixon, Andrew Felluss, Nick Howard, Timorhy Olmstead and Ryan Smith.
 Pro Tools Operation on Tracks 4, 5, 6, 8, 9, 10, 12 & 14 – Steve Deutsch, Andrew Felluss and Pete Karam.
 Mixing – Carter Humphrey (Tracks 1, 2, 3, 7, 11 & 13); Frank Filipetti (Tracks 4, 5, 6, 8, 9, 10, 12 & 14).
 Mix Assistants on Tracks 4, 5, 6, 8, 9, 10, 12 & 14 – Andrew Felluss and Timorhy Olmstead
 Tracks 1, 2, 3, 7, 11 & 13 mastered by Stephen Marcussen at Marcussen Mastering (Los Angeles, CA); Tracks 4, 5, 6, 8, 9, 10, 12 & 14 mastered by Ted Jensen at Sterling Sound (New York, NY).
 Special Production Support on Tracks 1, 2, 3, 7, 11 & 13 –  Lauren Wild
 Additional Production Support on Tracks 1, 2, 3, 7, 11 & 13 – Larry Emerine at Precision Lacquer (Los Angeles); Drew L. and Don Tyler at Quality CD Duplication (Los Angeles).
 Creative Director – Alli Truch
 Art Direction – Jeri Heiden for SMOG L.A.
 Photography – Andrew MacPherson
 Management – Annie Challis and Arnold
Stiefel at Stiefel Entertainment.
 Liner Notes – Rod Stewart and Bill Zehme

Live DVD
 "Forever Young" (Jim Cregan, Kevin Savigar, Bob Dylan, Rod Stewart)
 "Some Guys Have All the Luck" (Jeff Fortgang)
 "They Can't Take That Away from Me" (G. Gershwin, I. Gershwin)
 "The Way You Look Tonight" (Fields, Kern)
 "These Foolish Things" (Link, Marvell, Strachey)
 "Moonglow" (DeLange, Hudson, Mills)
 "Every Time We Say Goodbye" (Porter)
 "The Very Thought of You" (Noble)
 "That Old Feeling" (Brown, Fain)
 "You Go to My Head" (Coots, Gillespie)
 "For All We Know" (Coots, Lewis)
 "The Nearness of You" (Carmichael, Washington)
 "That's All" (Brandt, Haymes)
 "We'll Be Together Again" (Fischer, Laine)
 "Rhythm of My Heart" (Marc Jordan, John Capek)
 "Downtown Train" (Tom Waits)
 "Maggie May" (Stewart, Martin Quittenton)
 "Young Turks" (Stewart, Carmine Appice, Duane Hitchings, Savigar)
 "Hot Legs" (Stewart, Gary Grainger)
 "Having a Party" (Sam Cooke)
 "I'll Be Seeing You" (Fain, Kahal)
 "It Takes Two" (William "Mickey" Stevenson, Sylvia Moy)

Charts

Certifications

Album

DVD


Jorge Matute Remus

Jorge Matute (February 17, 1912 – July 6, 2002) was a Mexican engineer.

His movement of a 1700-ton Teléfonos de México (Mexican telecommunications) building in 1950 to widen a main street (Avenue Juarez) in Guadalajara earned him a place in the city's history. The building was moved 12 meters away from its original position with all the communication operators working inside. At 23 he designed and built a bridge for a federal Mexican road over Coy river in the Huasteca during a professional internship that gained him respect among engineers at such early stage of his life. He dedicated much of his life to the pursuit of a better urban planning, the provision of water for the city and the improvement of higher education. Matute was dean of the Universidad de Guadalajara (1949–1953) and municipal president (1953–1955) of the same city. He was given several honors by the University of Guadalajara (Masters and Doctoral (2006) Honoris Causa), UNESCO, the National Prize for Engineering, the French Academic Palms, among others.

Early life
Matute Remus was born in Guadalajara, the son of Juan Matute Gil and María Concepción Remus and second of five children. In his early years he had to work to help the household economy due to impoverishment caused by the Mexican revolution. In 1941 he married Esmeralda Villaseñor y Villaseñor and had four children: Juan Jorge, Elena, Esmeralda and Pedro.

Movement of the telecommunications building
The city of Guadalajara needed several modernization works and the state governor of Jalisco at the time, José de Jesús González Gallo, was dedicating plenty of attention to these changes. The broadening of Vallarta Avenue (a major avenue connecting Guadalajara's downtown to the west) was included. Buildings along the avenue were demolished, except for the telecommunications building, which would have left the city without telephone service for at least a week. At this situation, Jorge Matute, then dean of the city's university (Mexico's second-largest in student population), proposed to move the building 12 meters with all the workers inside and functioning as normal in order to keep the telephone service working. The works started with a budget of only $100,000 USD, only 17% of the cost of demolishing the building and constructing a new one. In order to gain the trust of the employees he asked his wife to enter the building while the movement was taking place. On October 28, 1950 the building was set on its final position, where it still stands with a statue of Matute pushing the building.

Other works
Founded and built Guadalajara's Technological Institute.
Founder of CETI (Center for technical and industrial education).
Built the Guadalajara's water system.
Founder member of ANUIES (National association of universities and higher education institutes)

Matute Remus Bridge
Matute Remus Bridge


Smolensk War

The Smolensk War (1632–1634) was a conflict fought between the Polish–Lithuanian Commonwealth and Russia.

Hostilities began in October 1632 when Russian forces tried to capture the city of Smolensk. Small military engagements produced mixed results for both sides, but the surrender of the main Russian force in February 1634 led to the Treaty of Polyanovka. Russia accepted Polish–Lithuanian control over the Smolensk region, which lasted for another 20 years.

Background
In 1632, Sigismund III Vasa, the king of Poland and Grand Duke of Lithuania, died. Although the Commonwealth nobility quickly elected Sigismund's son Władysław IV Vasa as their new ruler, Poland's neighbours, expecting delays in the electoral process, tested the Commonwealth's perceived weakness. Swedish king Gustav II Adolph sent envoys to Russia and the Ottoman Empire to propose an alliance and war against the Commonwealth.

The Commonwealth was not ready for war. In 1631, the royal army numbered barely 3,000 men; the Smolensk garrison was about 500 strong, and most garrisons in the border area were composed not of regular or mercenary soldiers but of 100 to 200 local volunteers. Aware that Russia was preparing for war, in the spring of 1632 the Sejm (Polish–Lithuanian parliament) increased the army by recruiting an additional 4,500 men; by mid-1632 the deputy voivode (podwojewoda) of Smolensk, Samuel Drucki-Sokoliński, had about 500 volunteers from pospolite ruszenie and 2,500 regular army soldiers and Cossacks. In May the Senate of Poland agreed to increase the size of the army, but Grand Lithuanian Hetman Lew Sapieha objected, arguing that the current forces were enough and that war was not likely. Nonetheless the Field Lithuanian Hetman Krzysztof Radziwiłł recruited an additional 2,000 soldiers.

Russia, having recovered to a certain extent from the Time of Troubles, agreed with the assessment that the Commonwealth would be weakened by the death of its king, and unilaterally attacked without waiting for the Swedes and the Ottomans. Russia's aim was to gain control of Smolensk, which it had ceded to the Commonwealth in 1618 at the Truce of Deulino, ending the last Russo-Polish War. Smolensk was the capital of the Commonwealth's Smoleńsk Voivodeship, but it had often been contested, and it changed hands many times during the 15th, 16th and 17th centuries (from the days of the Muscovite–Lithuanian Wars). A major supporter of the war was the Tsar's father, Patriarch Filaret, who represented the anti-Polish camp at court. Inspired by the Zemsky Sobor's (Russian parliament's) call for vengeance and reclamation of lost lands, the Russian army sallied west.

Hostilities
The Russian army that crossed the Lithuanian border in early October 1632 had been carefully prepared and was under the experienced command of Mikhail Borisovich Shein, who had previously defended Smolensk against the Poles during the 1609–1611 siege. Several towns and castles fell as the Russians advanced, and on 28 October 1632 (the same day that the historic town of Dorogobuzh was taken), Shein moved to begin the siege of Smolensk.

Former Polish estimates of the size of the Russian forces varied from 25,000 through 30,000 to 34,500, with 160 artillery pieces. Recent research on 17th-century Russian archive documents showed that the size of the Russian army was 23,961. Compared to former Russian armies, Shein's army was significantly modernised. Dissatisfied with their traditional formations of musket-equipped infantry (the streltsy), the Russians looked to foreign officers to update the equipment and training of their troops based on the Western European model of regulars, dragoons, and reiters. Eight such regiments, totaling 14,000 to 17,000 men, comprised part of Shein's army.

Siege of Smolensk

Commonwealth forces in Smolensk were composed of the Smolensk garrison (about 1,600 men with 170 artillery pieces under the command of the Voivode of Smolensk, Aleksander Korwin Gosiewski), strengthened by the local nobility, which formed a pospolite ruszenie force of about 1,500 strong. The city's fortifications had also recently been improved with Italian-style bastions.

Shein constructed lines of circumvallation around the fortress. Using tunnels and mines, his forces damaged a long section of the city wall and one of its towers. Russian heavy artillery, mostly of Western manufacture, reached Smolensk in December 1632 with even heavier guns arriving the following March. After a preliminary artillery bombardment, Shein ordered an assault, which was repulsed by the Polish defenders. Nonetheless the siege was progressing; Smolensk's fortifications were being eroded, and the defenders were suffering heavy casualties and running out of supplies. By June 1633, some soldiers started to desert, and others talked of surrender.

Despite these difficulties, the city, commanded by Deputy Voivode Samuel Drucki-Sokoliński, held out throughout 1633 while the Commonwealth, under its newly elected King Władysław IV, organised a relief force. The Sejm had been informed about the Russian invasion by 30 October 1632, and, starting in November, had discussed the possibility of relief. However, the process was delayed until the spring of 1633, when the Sejm officially sanctioned a declaration of war and authorised a large payment (6.5 million zlotys, the highest tax contribution during Władysław's entire reign) for the raising of a suitable force. The intended relief force would have an effective strength of about 21,500 men and would include: 24 chorągiews of Winged Hussars (~3,200 horses), 27 chorągiews of light cavalry—also known as Cossack cavalry but not composed of Cossacks—(3,600 horses), 10 squadrons of raitars (~1,700 horses), 7 Lithuanian petyhor regiments (~780 horses), 7 large regiments of dragoons (~2,250 horses), and ~20 regiments of infantry (~12,000 men). Over 10,000 of the infantry would be organized based on the Western model, previously not common in Commonwealth armies.

Meanwhile, Field Hetman of Lithuania and Voivode of Vilnius, Krzysztof Radziwiłł, and Voivode Gosiewski established a camp about  from Smolensk, moving from Orsha to Bajów and later, Krasne. By February 1633, they had amassed around 4,500 soldiers, including over 2,000 infantry, and were engaged in raiding the rear areas of the Russian besiegers to disrupt their logistics. Hetman Radziwiłł also managed to break through the Russian lines on several occasions, bringing about 1,000 soldiers and supplies into Smolensk to reinforce the fortress and raising the defenders' morale.

By the summer of 1633, the relief force, led personally by the king and numbering about 25,000 (20,000 in the Polish–Lithuanian army, according to Jasienica), arrived near Smolensk; they reached Orsha on 17 August 1633. By the first days of September, the main body of the relief forces approaching Smolensk numbered around 14,000. The Russian army, recently reinforced, numbered 25,000. Only when Cossack reinforcements, led by Tymosz (Timofiy) Orendarenko and numbering between 10,000 and 20,000, arrived on 17 September would the Commonwealth army gain numerical superiority. The Cossacks under Orendarenko and Marcin Kazanowski raided the Russian rear lines, freeing the Polish–Lithuanian units under Radziwiłł and Gosiewski to join the effort to break the siege.

Władysław's brother, John II Casimir, commanded one of the regiments in the relief army. Another notable commander was the Field Crown Hetman, Marcin Kazanowski. King Władysław IV, a great supporter of the modernization of the Commonwealth army, proved to be a good tactician, and his innovations in the use of artillery and fortifications based on Western ideas greatly contributed to the eventual Polish–Lithuanian success. He had replaced the old arquebusiers with musketeers, and standardized the Commonwealth artillery (introducing 3- to 6-pounder regimental guns), both to great effect.

Commonwealth's cavalry, including the Winged Hussars, significantly restricted Russian mobility, forcing them to stay in their trenches. In a series of fierce engagements, Commonwealth forces gradually overran the Russian field fortifications, and the siege reached its final stages by late September. On 28 September 1633, Commonwealth forces took the main Russian supply points, and by 4 October the siege had broken.

Shein's army retreated to its main camp, which was in turn surrounded by Commonwealth forces in mid-October. The besieged Russians waited for relief, but none arrived, as Commonwealth and Cossack cavalry had been sent to disrupt the Russian rear. Some historians also cite dissent and internal divisions in the Russian camp as responsible for their inaction and ineffectiveness. (Jasienica blames the Russian warlords, and Parker the foreign mercenaries.) The Tatar invasion threatening the south Russian borderlands was a contributory factor, with many soldiers and boyars from those regions deserting the Russian camp to return to protect their homeland. Some foreign mercenaries also deserted to the Commonwealth side.

Shein began surrender negotiations in January 1634, and by February they were in full swing. The Russians finally signed a surrender treaty on 25 February 1634, and on 1 March they vacated their camp. (Some scholars, such as Rickard and Black, give the date of 1 March for Shein's capitulation.) Under the surrender terms, the Russians had to leave behind most of their artillery but were allowed to retain their banners after a ceremony in which they were laid before King Władysław. They also had to promise not to engage Commonwealth forces for the next three months. Shein's forces numbered around 12,000 at the time of their capitulation, but over 4,000, including most of the foreign contingent, immediately decided to defect to the Commonwealth.

Other engagements
Several other towns and fortresses in the region were the site of smaller battles. Russian forces captured several significant locations during their advance in 1632, but Nagielski speculates that the delay in the arrival of their main force and artillery at Smolensk caused by this dilution of effort may have cost them the siege and consequently the war. In July 1633, the Russians took the towns of Polatsk, Velizh, Usvyat, and Ozerishche. Polatsk was the scene of particularly heavy fighting as the Russians captured the city and part of the fortress. However, attacks on Vitebsk and Mstsislaw were successfully repulsed. Polish forces laid siege to Putivl, but due to the desertion of their Cossack allies they were forced to withdraw.

In the autumn of 1633, Commonwealth forces retook Dorogobuzh, an important Russian supply point after its capture the year before. This setback wrecked Russian plans to send reinforcements to Shein's army, although in any event the Russians did not begin to gather a 5,000-strong army for that purpose until January 1634. Also that autumn, Grand Crown Hetman Stanisław Koniecpolski defeated an Ottoman incursion in the south of the Commonwealth, freeing his force to lay siege to the Russian town of Sevsk; although Koniecpolski failed to take the fortress, he tied down large Russian forces, preventing them from moving north towards Smolensk.

After the relief of Smolensk in the spring of 1634, the Commonwealth army moved towards the fortress Belaya. However, the siege of Belaya turned to a fiasco although the king manage to capture Vyazma.

Treaty of Polyanovka

By the spring of 1634, the Russians had not only lost Shein's army but were threatened by Tatar raids that ravaged southern Russia. Patriarch Filaret had died the previous year, and without him the war fervour lessened. Even before the end of 1633, Tsar Michael of Russia was considering how best to end the conflict. Because he had once been elected Tsar of Russia and could realistically lay claim to the Russian throne, King Władysław wanted to continue the war or, because the Polish-Swedish Treaty of Altmark would soon be expiring, ally with the Russians to strike against Sweden. However, the Sejm wanted no more conflict. As Stanisław Łubieński, the Bishop of Płock, wrote two weeks after Shein's surrender: "Our happiness is in remaining within our borders, guaranteeing health and well-being." With neither side keen on prolonging the war, they began negotiating, not for an armistice but for "eternal peace."

Talks began on 30 April 1634, and the Treaty of Polyanovka was signed in May, putting an end to hostilities. The treaty confirmed the pre-war status quo, with Russia paying a large war indemnity (20,000 rubles in gold), while Władysław agreed to surrender his claim to the Russian throne and return the royal insignia to Moscow. Jasienica notes that from the Russian perspective it was likely that Władysław's abnegation of his claim was more important, in terms of the subsequent increase in internal stability, than the loss of disputed borderland. Despite not winning militarily, the Russians may have scored a diplomatic triumph. Other authors, such as Hellie, support this interpretation.

Aftermath

Already during the later stages of the war, when the Commonwealth army moved from Smolensk to Bely, a new threat begun to loom on the southern borders, where the Ottoman Empire was massing an invasion force. Thus Władysław began redirecting his reinforcements to that theater. Later that year, the Commonwealth forces under Stanisław Koniecpolski scored a victory in the south, ending a war against the Ottomans.

Both sides introduced new tactics, units and equipment based on Western models, but the Polish–Lithuanian forces proved more adept with these innovations than the Russians. However, the main factors that kept the Russians from winning were the delay in moving siege artillery to Smolensk and the severe disruption of Russian supply lines by Polish cavalry. A scapegoat was nevertheless needed: Mikhail Shein was accused of treason and, together with his second-in-command Artemy Izmaylov and the latter's son Vasily, executed in Moscow on April 28, 1634. Learning from this defeat, the Russians would adopt new and more successful tactics in the Polish–Russian War (1654–1656).

After the war, Władysław gave the Russians the border town of Serpeysk and nearby territories, hoping to persuade the Tsar to join in an anti-Swedish alliance. However, the king was ultimately unable to overcome objections from the Polish–Lithuanian Sejm, who were unwilling to fight Sweden after the Treaty of Sztumska Wieś. The Russians, unable to see benefit in such an alliance, were also unenthusiastic, and the proposed alliance came to nothing.

The war cost the Commonwealth treasury about 4,300,000 zloties.

The Battle of Smolensk is commemorated on the Tomb of the Unknown Soldier, Warsaw, with the inscription "SMOLENSK 18 X 1632–25 II 1634".


Kozármisleny SE

Kozármisleny SE is a football club based in Kozármisleny, Hungary. The team is currently playing in the league NB2, which is the second tier of Hungarian football.

External links
Official site


Japenzin

Japenzin is a village and a former municipality in the Vorpommern-Greifswald district, in Mecklenburg-Vorpommern, Germany. Since 7 June 2009, it is part of the municipality Spantekow.


The Warren County Board of Chosen Freeholders is a body of three people that govern Warren County, New Jersey. The members of the board are referred to as freeholders.

Structure
The board is responsible for the governance of Warren County, New Jersey. They set out the budget for the county as well as the laws in the county. Each year the members choose to people on the board to serve as Director and Deputy Director. The current Director is Freeholder Jason Sarnoski and Freeholder Richard Gardner is serving as Deputy Director.

Party affiliation

Sessions

2019
In 2018 Freeholder Edward Smith announced his retirement and James Kern was nominated to his seat. Kern won the election and was sworn in on January 1.

Previous Sessions


Niemann–Pick disease, SMPD1-associated

Niemann–Pick disease, SMPD1-associated refers to two different types of Niemann–Pick disease which are associated with the SMPD1 gene.

There are approximately 1,200 cases of NPA and NPB worldwide with the majority of cases being Type B or an intermediate form.

Descriptions of type E and type F have been published, but they are not well characterized, and are currently classified under type B.

Genetics
Mutations in the SMPD1 gene cause Niemann–Pick Types A and B. This gene carries instructions for cells to produce a lysosomal enzyme called acid sphingomyelinase.  Insufficient activity of the enzyme acid sphingomyelinase causes the buildup of toxic amounts of sphingomyelin, a fatty substance present in every cell of the body.  This enzyme is found in special compartments within cells called lysosomes (compartments that digest and recycle materials in the cell), and is required to metabolize the lipid sphingomyelin.  If sphingomyelinase is absent or not functioning properly, sphingomyelin cannot be metabolized properly and is accumulated within the cell, eventually causing cell death and the malfunction of major organ systems.

Diagnosis

Type A
Niemann–Pick Type A, the most common type, occurs in infants and is characterized by jaundice, an enlarged liver, failure to thrive, progressive deterioration of the nervous system and profound brain damage. Children affected by Niemann Pick Type A rarely live beyond 18 months.  Niemann–Pick Type A occurs more frequently among individuals of Ashkenazi (eastern and central European) Jewish descent than in other ethnicities. The incidence within the Ashkenazi population is approximately 1 in 40,000 people. The incidence for other populations is 1 in 250,000 people.

Type B
Niemann–Pick Type B involves an enlarged liver and spleen hepatosplenomegaly, growth retardation, and problems with lung function including frequent lung infections.  Other signs include blood abnormalities such as abnormal cholesterol and lipid levels, and low numbers of blood cells involved in clotting (platelets).  The brain is not affected in Type B and the disease often presents in the pre-teen years.

Treatment


Tom Freddy Aune

Tom Freddy Aune (born 3 June 1970) is a Norwegian former football forward and coach. He was most
recently the head coach of Fredrikstad.

As a player Aune played for Fredrikstad at the second and third tier from 1990 to 1999 only interrupted by two seasons at Sogndal, where he got 19 appearances in Tippeligaen in 1994.

Early life
Aune was born in Oslo, and as a kid he played two years for Enebakk. His family then moved to Lisleby in Fredrikstad, and he started playing for Lisleby FK.

Player career
Aune made his debut for Lisleby's first team in 1988, and the next season he scored 22 goals for the club, which were playing at the fourth tier.

Ahead of the 1990 season he transferred to Fredrikstad FK. The club was then playing at the second tier, and Aune was a regular starter for the team. In 1991, he scored nine goals, and was the team's second top goalscorer, only beaten by Stian Solberg, who scored ten goals. In 1992 Fredrikstad was relegated to the third tier for the first time in the club's history. A lot of players left the club, but Aune stayed for one more year. Fredrikstad finished second in the 1993 Second Division, and Aune was the team's top goalscorer with ten goals.

Aune then moved to Sogndal, and played 19 matches in Tippeligaen in 1994, when the team was relegated. He played for Sogndal until August 1995, when he moved back to his home-town team Fredrikstad. He played four more years for Fredrikstad, before he moved to the local rivals Sarpsborg, where he spent two seasons before he retired.

Coaching career
After his retirement, Aune worked several years as a teacher in high school. He was hired as youth coach in Fredrikstad in 2002, but after one year he quit the job because FFK wanted Aune to work full-time as youth coach while Aune wanted to still be a teacher. After one year as head coach in his youth-club Lisleby, and one year as head coach in Kvik Halden, Aune was again hired as youth-coach in Fredrikstad in October 2004. When Anders Grönhagen was signed as head coach of Fredrikstad, Per Morten Haugen and Aune become assistant coaches. Aune quit his job as a teacher in 2008, and during the 2009-season he stepped in temporarily as head coach when Grönhagen was on a sick leave. Ahead of the 2010-season Aune was appointed as the new head coach of Fredrikstad, and during his first season the club won promotion to Tippeligaen after beating Hønefoss in the promotion-playoff.


Orde Ballantyne

Orde Ballantyne (born 22 January 1962) is a Vincentian athlete, who competed at the 1988 Summer Olympics.

Career
Ballantyne became the first Vincentian to win a gold medal at the CARIFTA Games when competing in the shot put at the 1981 CARIFTA Games held in Nassau, Bahamas.
Six years later Ballantyne competed at the first ever IAAF World Indoor Championships in Athletics held in Indianapolis, United States, he entered the 60 metres and finished fourth in his heat in a time off 7.05 seconds which was a new national record, but still wasn't fast enough to qualify for the next round, he also entered the long jump but didn't make any legitimate jumps so didn't receive an official ranking.

Ballantyne was also part of the first ever Saint Vincent and the Grenadines team to compete at the Summer Olympics in 1988 when they went to Seoul, South Korea, he entered the long jump, but again he failed to register a distance from his three jumps so he didn't advance any further.


John Kent (cartoonist)

John Kent (21 June 1937 – 14 April 2003) was a New Zealand cartoonist who is best known as the author of the erotic and satirical Varoomshka comic strip in the English newspaper The Guardian during the 1970s.

Biography
Born in Oamaru, Kent was self-taught as an artist, influenced by Al Capp, creator of Li'l Abner. He worked principally in felt-tip pen on A4 paper. Kent emigrated to England in 1959, working in advertising before his Grocer Heath strip was published in Private Eye in 1969. Varoomshka appeared in The Guardian from 1969 to 1979, Kent also contributing work to The Sun, The Daily Mail, The Sunday Times and, from 1998, The Times, where his La Bimba strip showed clear echoes of the earlier Varoomshka.

Sources

External links
Michael McNay, "John Kent" obituary, The Guardian, 19 April 2003.
Mark Bryant, Obituary from The Independent, 21 May 2003.
Biography from British Cartoon Archive, University of Kent
John Kent at lambiek.net


Belgian Bowl XVI

In the Belgian Bowl XVI, the Antwerp Diamonds were disqualified giving the title to the Brussels Black Angels.

2003 standings


The Year's Best Science Fiction: Eleventh Annual Collection is an anthology of science fiction short stories edited by Gardner Dozois, the eleventh volume in an ongoing series. It was first published in hardcover and trade paperback by St. Martin's Press in August 1994, with a book club edition co-issued with the Science Fiction Book Club following in September 1994. The first British edition was published in hardcover by Robinson in October of the same year, under the alternate title The Best New Science Fiction: 8th Annual Collection.

Summary
The book collects twenty-three novellas, novelettes and short stories by various science fiction authors, with an introductory summation of the year, notes and concluding list of honorable mentions by the editor. The stories were previously published in 1993 in various science fiction and other magazines.

Contents
"Summation: 1993" (Gardner Dozois)
"Papa" (Ian R. MacLeod)
"Sacred Cow" (Bruce Sterling)
"Dancing on Air" (Nancy Kress)
"A Visit to the Farside" (Don Webb)
"Alien Bootlegger" (Rebecca Ore)
"Death on the Nile" (Connie Willis)
"Friendship Bridge" (Brian W. Aldiss)
"Into the Miranda Rift" (G. David Nordley)
"Mwalimu in the Squared Circle" (Mike Resnick)
"Guest of Honor" (Robert Reed)
"Love Toys of the Gods" (Pat Cadigan)
"Chaff" (Greg Egan)
"Georgia on My Mind" (Charles Sheffield)
"Cush" (Neal Barrett, Jr.)
"On the Collection of Humans" (Mark Rich)
"There and Then" (Steven Utley)
"The Night We Buried Road Dog" (Jack Cady)
"Feedback" (Joe Haldeman)
"Lieserl" (Stephen Baxter)
"Flashback" (Dan Simmons)
"A Child's Christmas in Florida" (William Browning Spencer)
"Whispers" (Maureen F. McHugh and David B. Kisor)
"Wall, Stone, Craft" (Walter Jon Williams)
"Honorable Mentions: 1993" (Gardner Dozois)

Awards
The anthology placed first in the 1995 Locus Poll Award for Best Anthology.

Notes

11


Ek Ke Baad Ek

Ek Ke Baad Ek () is a 1960 Indian Hindi-language film directed by Raja Rishi. The film stars Dev Anand, Sharada and Tarla Mehta.

Plot
Mangal (S. K. Prem) lives with his wife Laxmi (Tarla), their six children and his younger brother Prakash (Dev Anand). Mangal has taken a loan from a local moneylender for Prakash's college education. Mangal's poverty is so bad that he sells his sixth child's bed to buy a blanket. Soon, Laxmi dies due to the family not being able to afford to buy medicine. Meanwhile, Prakash becomes well-educated with a modern outlook and a reformist attitude, he confronts his brother every now and then with hard truths of life. Mangal calls Prakash an iconoclast and asks him to leave the house. This affects the lives of Prakash and his girlfriend Sandhya (Sharada). Her father Gangu Teli (Radhakrishan), a small time businessman, does not approve of their marriage. Prakash loses his cool when he finds his nephews and nieces begging for a living. He then immediately takes up a job in a printing press that promotes family planning and other social issues. After obtaining the advance, Prakash arranges food and clothes for his kin, using Sandhya as the go-between. After Mangal loses his job he requests Gangu Teli to take him to the temple priest, Sanatan (Hiralal) with a request for advance, who while saying he is helpless appeals to the assembly to help him with whatever they can spare. This invokes Mangal’s conscience and he rushes back home.

Cast
Adapted from The Hindu.
Dev Anand as Prakash
Sharada as Sandhya
Tarla Mehta as Laxmi
Radhakrishan as Gangu Teli
Hiralal as Sanatan
S. K. Prem as Mangal
Madhu Apte

Soundtrack

The music was composed by S. D. Burman while Kaifi Azmi wrote the lyrics. On the album, film critic Suresh Kohli of The Hindu noted that except for "Chali Yeh Fauj Humari" and "Thumak Thumak Chali Hai", the other songs were "not really hummable".

Reception
Kohli wrote that the film "was a well-intended message-laden story with a weak, confused screenplay attempting to cash on Anand’s newly formed stardom." The film did not do well at the box office.


Hamelinus Decanus (Dean of Lincoln)

Hamelinus Decanus (Hamelin the Dean) was a Priest in the Roman Catholic Church and founder of the Alvingham Priory

Career
Hamelinus  established a charter which allowed 'The order of St. Gilbert of Sempringham' the creation of Alvingham Priory during the time of Pope Eugene III, between 1145 and 1153. The Charter also shows that the Church of Alvingham was given to Robert de Chesney then Bishop of Lincoln who invested the monks at Alvingham Priory. Hamelinus had made during this time substantial land donations to Alvingham Priory. Hamelinus goes on to provide a gift to the Gilbertine nuns three-quarters of 'his' Parish Church of Alvingham to add to that given to them by their founder Roger son of Jocelin. Therefore, he must have been the Vicar of the Parish Church of Alvingham, as well as its patron and a substantial land holder.

The 'ecclesiae Anlicanae' records that about 1164 Hamelinus was a Dean of Lincoln. He is referred to by some however as Dean of Yarburgh (Yarburgh becoming Yarborough). As the Church in Alvingham was in Louthesk he is more likely to have been Dean there however (Louthesk becoming Ludborough). although as always with these things this is not clear

Regardless about the time of 1164 he is also shown as a Prebendary of Aylesbury which at this time appeared to be a role performed by a Dean of Lincoln.

Hamelinus is known to have resigned from his deanery position however and joined Alvingham Priory as a canon. There he made further gifts of land from the Parish of Grainthorpe.

Family
Hamelinus appears to have been married for he had at least five sons. One of which was called Brian.

He was probably the nephew of Hugh of Avalon who was Bishop of Lincoln.


Fast5

Fast5 (originally called Fastnet) is a variation of netball featuring shortened games and goals worth multiple points. The new format was announced by the International Federation of Netball Associations (IFNA)(now the International Netball Federation) in 2008, and was primarily developed for a new international competition, the Fast5 Netball World Series. The rules were revamped for 2012, with the variation being renamed Fast5.

Background
In 2008, the IFNA released the details of a new, faster format of netball, which eventually became known as "fastnet". The new format was developed for a new international netball competition, the World Netball Series. According to the IFNA, the new rules were ultimately designed to make games faster and more television-friendly, with the ultimate aim of raising the sport's profile and attracting more spectators and greater sponsorship. Previously, the new rules had been trialled by England junior and senior netball squads over a 12-month period. Some of the new rules were announced in December 2008, including six-minute playing quarters and power plays; others were announced in February 2009. The new format was quickly compared to Twenty20 cricket and rugby sevens.

Playing rules
Fast5 features modified rules that are outlined below. Outside of these, the standard rules of netball apply (see Netball rules).
 Players: Each side only has five players on the court, compared with seven in normal netball competition.
 Timing: Each quarter lasts only six minutes, compared with 15 minutes in normal international netball competition. Breaks in between quarters are two minutes each. Injury time-outs are 30 seconds only; standard rules allow for one initial two-minute injury time-out.
 Coaching: Coaches can give instructions to players from the sidelines during play, from in front of their playing bench. Standard international rules do not allow coaching during play.
 Substitutions: Teams are allowed to use rolling substitutions, with no stoppages in play per substitution and with unlimited substitutions per quarter. Standard international rules only allow substitutions either between quarters or when a player is injured.
 Power plays: Each team can separately nominate one "power play" quarter, in which each goal scored by that team counts for double points. This is somewhat similar to power plays in One Day International and Twenty20 cricket, although it is not a feature of standard netball. The two teams cannot nominate the same quarter to be their power play.
 Two and Three-point shots: Similar to three-point field goals in basketball and two-point goals in six-a-side indoor netball, the goal shooter (GS) and goal attack (GA) may shoot goals from outside the shooting circle. These goals count for two points if scored from inside the outer zone and three points if scored in the super shot zone; in a power-play quarter, they would count for four  and six points respectively. In standard netball rules, goals can only be shot from within the shooting circle and count for one point only.
 Centre passes: After each goal, the team that conceded the goal takes the next centre pass; teams alternate taking the first centre pass of each quarter. Under normal rules, a coin toss determines the first centre pass of the match, after which centre passes alternate between the two teams.
 Tied scores: Tied games are decided by penalty shoot-outs, similar to those in association football. Often in competitive netball, tied games simply continue until one team wins in extra time, or else subsequently achieves a two-goal advantage.

Competitions
The main Fast5 competition is the Fast5 Netball World Series; presently, it is the only international competition based on the new format. It was first held in October 2009 and is contested on an annual basis between the top six national netball teams in the IFNA World Rankings. Regional fastnet competitions also emerged in 2009 in England. The Jamaica Netball Association announced plans for a domestic fastnet competition in their country starting in 2010. In the United Kingdom, the British Fast5 Netball All-Stars Championship was launched in 2017 and is fought by each of the teams that participate in the Netball Superleague, the elite domestic netball competition in the UK.


Frederick Campbell Rose

Frederick Campbell Rose CSI (1865 – 18 July 1946) was a Scottish civil engineer who spent most of his career in India.

Rose was born in Elgin and educated at Trinity College, Glenalmond and the Royal Indian Engineering College. He joined the Indian Public Works Department in 1886 and was posted to the Irrigation Branch in the Punjab, where he spent most of his career, becoming a leading authority on irrigation. In 1916 he was appointed Secretary of the Public Works Department, which carried with it membership of the Viceroy's Legislative Council.

He retired from Indian service in 1919 to take up the post of chief engineer of river improvements in the Chili Province of Northern China, finally retiring in 1927.

Rose was appointed Companion of the Order of the Star of India (CSI) in the 1920 New Year Honours.

Footnotes


The Wildcats of St Trinian's

The Wildcats of St. Trinian's is the fifth British comedy film set in the fictional St Trinian's School. Directed by Frank Launder, it was released in 1980.

The film pokes fun at the British trade union movement which had been responsible for the recent wave of strikes that culminated in the Winter of Discontent.

The film was not a critical or commercial success. It has yet to be released on DVD except in the US.

Plot
The girls of St. Trinian's hatch yet another fiendish plot—a trade union for British schoolgirls. Their friend and mentor, Flash Harry, suggests a plan which involves kidnapping girls from other rather more respectable colleges and substituting their own "agents". Thus begins a hilarious, often bloody, battle of wits as the girls meet resistance not only from Olga Vandermeer, their Headmistress, but from the Minister of Education, a private detective, and an oil sheikh. Despite all his desperate efforts to foil the conspiracy, the Minister has to face a growing realisation that the girls' demands will have to be met—for him this will mean a very great and very personal sacrifice.

Cast

 Sheila Hancock as Olga Vandemeer
 Michael Hordern as Sir Charles Hackforth
 Joe Melia as Flash Harry
 Thorley Walters as Hugo Culpepper Brown
 Rodney Bewes as Peregrine Butters
 Deborah Norton as Miss Brenner
 Maureen Lipman as Miss Katy Higgs
 Julia McKenzie as Miss Dolly Dormancott
 Ambrosine Phillpotts as Mrs Mowbray
 Rose Hill as Miss Martingale
 Diana King as Miss Mactavish
 Luan Peters as Miss Poppy Adams
 Barbara Hicks as Miss Coke
 Rosalind Knight as Miss Walsh
 Patsy Smart as Miss Warmold
 Bernadette O'Farrell as Miss Carfax
 Sandra Payne as Miss Taylor
 Hilda Braid as Miss Summers
 Ballard Berkeley as Humphrey Wills
 Frances Ruffelle as Angela Hall / Princess Roxanne
 Danielle Corgan as Eva Potts
 Lisa Vanderpump as Ursula
 Debbie Linden as Mavis
 Veronica Quilligan as Lizzie
 Miranda Hunnisett as Jennie
 Eileen Fletcher as Harriet
 Sarah-Jane Varley as Janet
 Theresa Ratcliff as Maggie
 Sandra Hall as Frieda
 Suzanna Hamilton as Matilda

Production
It had been ten years since the previous St Trinians film. "I didn't want to do another St Trinians unless it could top the previous one," said Launder during filming. "I think this one does." Sidney Gilliat was a production consultant.

Reception
Derek Malcolm of The Guardian called it "one of the worst films I've ever seen... Please don't do anything like it again. Ever."

Launder wanted to follow to the film with an adaptation of the books by Norman Thelwell about a pony school. He almost made it in Norway in the late 1970s and in 1979 planned on making it in Britain the following year. However no movie resulted.