Louis Humphreys
Louis Humphreys (September 21, 1816 - May 9, 1880) was a doctor, medical inspector for the Union Army during the American Civil War, and two-term mayor of South Bend, Indiana (1868 - 1872). He was born in Ohio. Abraham Lincoln appointed him as one of eight medical inspectors for the United States Army.

Humphreys was born in Springfield, Ohio. His older brother Harvey was also a doctor. Humphreys came to South Bend in 1844.

He was the second mayor of South Bend. He was a Republican.

Humphreys' father was a native of Ireland who immigrated to the U.S. in his early 20s.

Humphreys was involved in organizing South Bend's original public library.