Estradiol/norethisterone acetate
Estradiol/norethisterone acetate (E2/NETA), sold under brand names including Activella, Amabelz, Estracomb, Kliofem, and Novofem, is a combination of estradiol (E2) and norethisterone acetate (NETA) which is used in the treatment of vasomotor symptoms, vulvar and vaginal atrophy, and osteoporosis associated with menopause. Activella specifically is marketed by Novo Nordisk and is supplied as film-coated tablets containing 1 mg estradiol and 0.5 mg norethisterone acetate. CombiPatch is a combination of estradiol and NETA provided as a transdermal patch.