HSC
HSC may stand for:

Business
 Hughes Systique Corporation
 Halifax Shopping Centre
 Harmonized System Code
 Harsco Corporation

Computing
 Hitachi Data Systems Corporation Storage Cluster
 HSC50 (Hierarchical Storage Controller Model 50), a mass storage controller from Digital Equipment Corporation implementing their Mass Storage Control Protocol
 Hughes Systique Corporation

Medicine
 Health and Social Care in Northern Ireland
 Hematopoietic stem cell
 Hepatic stellate cell
 Hospital for Sick Children, Toronto, Canada
 Hydraulic Sinus Condensing, a technique used in dentistry to lift the sinus
 Hysteroscopy, a method for looking into the uterus via the cervix

Organizations
 Health Service Commissioner for England
 Health Sponsorship Council
 Heraldry Society of Canada
 Huntington Society of Canada
 Health and Safety Commission
 United States Homeland Security Council
 Harare Sports Club, sports venue in Zimbabwe

Schooling

Certificates

 Higher School Certificate (New South Wales) (New South Wales, Australia)
 Higher School Certificate (Victoria), the former high school leaving certificate in Victoria, Australia which was superseded by the Victorian Certificate of Education
 Higher School Certificate (UK), a British qualification which preceded the A Level
 Higher Secondary (School) Certificate (Bangladesh, India and Pakistan)

Schools
 Hampden–Sydney College
 Hillfield Strathallan College, private school in Hamilton, Ontario, Canada
 Hsin Sheng College of Medical Care and Management, private junior college in Taoyuan City, Taiwan

Related
 High School Cadets
 Hindu Students Council

Other
 High-speed craft
 Home Shopping Club, former name of the Home Shopping Network
 Hot Sauce Committee Part Two, an album by the Beastie Boys
 Houston Ship Channel
 Hyper Suprime-Cam, an ultra-wide-field camera for Subaru Telescope
 The Mauser HSc pistol
 Shaoguan Guitou Airport, IATA code