Is neurocysticercosis a risk factor for glioblastoma multiforme or a mere coincidence: A case report with review of literature
A 47-year-old male presented in radiotherapy out door in December 2011 with history of repeated episodes of seizures and persistent headache for 4 months, weakness in left side of the body for 10 days, and altered sensorium for 3 days. His medical history revealed that he had NC 2 years back [Figure and ], for which he received a course of antihelmenthics (Albendazole) and advised antiepileptic (Phenytoin). Subsequently patient was lost to follow up and stopped antiepileptic after 7 months. He again presented now after 2 years with the above complaints. On examination, patient had Glasgow coma scale of 13 (E4 V3 M6) and power of left upper and lower limb was 4/5. Contrast enhanced magnetic resonance imaging (MRI) brain showed multiple cystic ring enhancing lesions along with predominant enhancing lesions in the corpus callosum []. On retrospective review of initial brain MRI and comparing it with present one, it was suggestive of preexisting simultaneous glioma lesion along with NC which progressed to glioblastoma multiformme over a period of 2 years in same corpus callosum region of brain while NC lesions seem to be healed. Patient underwent right frontal craniotomy and total excision of tumor. Postoperative histopathology examination revealed GBM []. Patient has been started on Radical Radiotherapy with 3DCRT with intent to deliver radical dose of 60Gy in 30 fractions over 6 weeks in phased manner. In view of his poor financial status no chemotherapy has been planned.