Limitations and obstacles of the spontaneous adverse drugs reactions reporting: Two “challenging” case reports
A 58-year-old female accessed hospital for acute respiratory failure secondary to asthma attack. Physical examination of the chest showed reduced breath sounds with scattered groans and wheezes, and SpO2 (arterial oxygen saturation measured by pulse oximetry) of 89%. The patient had a history of bronchial asthma treated with short-acting β2-agonist bronchodilators for about 10 years. Additionally, since 4 weeks he was taking bimatoprost 0.1 mg/ml, eye drops, solution (Lumigan®-Allergan Pharmaceuticals Ireland) for the treatment of open-angle glaucoma. The patient was treated with intravenous corticosteroid therapy, adrenaline by aerosol and oxygen.\nAfter hospital discharge, the patient reported what happened to her specialist ophthalmologist who diagnosed an asthmatiform crisis likely secondary to treatment with prostanoids and, therefore, decided to discontinue bimatoprost treatment.