Adenoid Cystic Carcinoma of the Breast: A Case Series of Six Patients and Literature Review
A 47-year-old female presented with a palpable mass in her left breast, which she had discovered three years before being seen by us. Mammography and breast US showed multiple masses in the left upper breast. Breast MRI showed an enhancing lobulated mass measuring 1.1×1.2 cm in the left upper breast and multiple small adjacent and posterior nodules. Results of a subsequent diagnostic core biopsy revealed an infiltrative ductal carcinoma with features of ACC. The patient underwent a modified radical mastectomy (MRM) with SLNB. Histopathologic examination of the resected specimen showed multiple ACCs measuring a total of 4.2×2.3×3 cm. There were no metastatic lymph nodes (pT2N0M0). IHC was negative for ER, PR, and HER2 expression. The patient underwent six cycles of adjuvant chemotherapy using cyclophosphamide, methotrexate, and 5-fluorouracil. She has been free of recurrence for 48 months.