A Case of Muir-Torre Syndrome with Multiple Cancers of Bilateral Eyelids and Breast
A 71-year-old woman presented with a swelling on her left upper eyelid in 2009. She also had a small mass on her right upper eyelid that been present for the previous 3 years. She had a history of breast cancer occurring in 1991, which was treated successfully without recurrence for 18 years. Laboratory data tests showed no remarkable changes. There was a significant family history of cancer; two of her brothers had also been diagnosed with cancers. Surgical excision and skin biopsy identified a sebaceous carcinoma in her right eyelid and a morphea-like basal cell carcinoma of her left eyelid (). Immunohistochemical analysis was done using anti-mutL homolog (MLH) 1 (mouse monoclonal; 1:50; BD Pharmingen, San Diego, CA, USA) and anti-MSH2 (mouse monoclonal; 1:40; Calbiochem, San Diego, CA, USA). A MLH1 gene product was present in both tumors, but no MSH2 genes were found in either tumor (). Colon cancer tissue obtained from another patient was used as a positive control specimen, with the patient's permission.