Development of acute dystonia in three brothers due to metoclopramide
The patient was 15 years old and male. The story was same with his brothers. Ten mg doses of metoclopramide had been prescribed to the patient. Conscious of the patient was clear but he was agitated and restless. Pulse was 92/min; blood pressure was 125/85 mmHg. Respiratory rate was 22/min as normal. There were speech dysfunction, trismus and dystonic movements of arms. And involuntary movements gradually increased and opistotonus developed. Results of CBC, liver, and kidney function tests and electrolytes were found as normal. Examination of the other systems was also normal.\nWe considered that acute dystonic reaction originated from metoclopramide, because the complaints of three brothers began suddenly onset and there were no similar complaints before. Therefore, biperiden 5 mg (IM) was performed to all three cases in order to treat them. The symptoms disappeared dramatically after 10 min from drug application. Patients were followed in observation room and there were no additional developing problem after the observation. Therefore, he was discharged to come back for control. The family was informed about the issue.