Striatal Dopaminergic Functioning in Patients with Sporadic and Hereditary Spastic Paraplegias with Parkinsonism
This 73-yr-old male showed gait disturbance at age 71. On walking, he showed a typical spastic gait with postural abnormality. The patient had spastic paraparesis with bilateral Babinski signs and brisk DTRs. After reviewing his sleep pattern, we concluded he had rapid eye movement (REM) sleep behavior disorder (RBD) and periodic limb movement disorder (PLMD). He was diagnosed approximately 8 yr prior with benign prostate hypertrophy, and was suffering from voiding symptoms including frequencyuria and urgency. The genetic tests, including Friedreich ataxia, SPG4, and SCA types 2 and 3, were normal.