Cisplatin induced paroxysmal supraventricular tachycardia
Our patient was a 55-year-old male who had been recently diagnosed as having small cell carcinoma of the right lung. Patient was normotensive and had no underlying cardiac illness. Baseline electrocardiogram (ECG) and Echocardiography were normal as were other parameters []. He was planned for cisplatin based chemotherapy Cisplatin (62 mg D1, D2 + Etoposide 165 mg D1, D2, D3). Patient received first cycle of chemotherapy uneventfully. During the second cycle while on cisplatin infusion, patient complained of palpitations. An ECG was performed that revealed PSVT []. Cisplatin infusion was stopped and the patient was given diltiazem 15 mg intravenous. Meanwhile, blood samples were collected for serum Na+, K+, Ca2+ and Mg2+, which were reported as normal. Echocardiography and electrophysiological studies were carried out later, which were normal. Besides, subsequent ECGs were also normal []. Patient received tab bisoprolol 5 mg prior to each cycle and didn’t develop any arrhythmia in subsequent cycles.