A unique case of Turner syndrome accompanying prolactinoma and unexpected elongated styloid process: Clinical and cone-beam computed tomographic features
A 40-year-old female patient was referred to ukurova University Faculty of Dentistry with the requisition of orthodontic treatment and odontalgia due to dental caries. Medical anamnesis of the patient revealed that she had TS accompanying prolactinoma and osteoporosis (). The patient was also receiving care from the endocrinology, neurology, and physical and rehabilitation medicine departments at the university hospital. A general physical examination showed that the patient height was 140 cm and weight 40 kg with normal gait and vital signs. According to the patient's medical history, it was revealed that she had undergone ear surgery due to otorrhea and recurrent otitis media at the age of 6. She had been diagnosed with TS at the age of 12 by endocrinologists due to the patient's complaints of amenorrhea and shortness in stature. At the age of 16, prolactinoma had been diagnosed with the complaints of visual disturbances and chronic headaches. The patient had been on medical treatment (dopamine agonist therapy) for a period of about 8 years for the tumor. She had responded to the medical treatment well without needing any surgical treatment. However, the last cranial magnetic resonance imaging (MRI) of the patient showed a recurrence of the prolactinoma. She has been continuing to follow up at the neurology clinic and receiving medical treatment with a dopamine agonist for her microadenoma ().\nThe patient's general clinical symptoms were hirsutism, amenorrhea, congenital speech difficulties, partial hearing loss, sinusitis, headache, neck and throat pain, and dysphagia (). She used calcium supplements, oral bisphosphonate, and vitamin D for osteoporosis; ethinyl estradiol for increasing growth velocity; cyproterone for hirsutism; and lansoprazol for peptic ulcer.\nThe intraoral examination and panoramic radiograph demonstrated that the patient had malocclusion, maxillary micrognatia, high and narrow palatal arch, retrusive mandible, bifid uvula, prevalent microdontia, hypoplastic first maxillary premolars, and short dental roots ( and ). The dental caries of the patient were restorated in the pediatric dentistry clinic.\nWe utilized the patient's CBCT (Iluma cone-beam CT Scanner, Imtec Imaging L.L.C., Ardmore, OK, USA) scan, which was performed for orthodontic evaluation, and detected a number of craniofacial abnormalities specific to TS. The dental tomographic examination showed the crowding of teeth, especially in the maxillary anterior region, because of the maxillary narrowness. The maxilla and mandible were both micrognathic. Relative mandibular retrusion, malocclusion and open-bite were observed (). An elongated styloid process (length of 32.7 mm) was also detected on the right side ().\nThe patient was referred to the otolaryngology department of the university hospital for a detailed examination and assessment of speech problems. The temporal bone axial and coronal computed tomography (CT) reports noted that the tympanic membranes looked thick and retracted bilaterally; on the left side, peripheral soft tissue density appeared at the external auditory canal. Otoscopic examination showed that the right tympanic membrane was intact and calcified plaques were visible around the tympanic membrane. The left tympanic membrane was perforated, and there was an adhesion to the head of the stapes. According to endoscopic rhinoscopy, the nasal septum deviated to the left side; there was also a slight polypoid degeneration in the middle nasal conchas and adenoid vegetation at the nasopharynx. Otolaryngologists recommended surgical treatment for ES, but the patient rejected the surgical intervention.