Aspiration pneumonia caused by fentanyl-induced cough -a case report-
A 32-year-old man (height 168 cm, weight 66 kg) was presented for a hand-assisted laparoscopic left nephrectomy for renal cell carcinoma. He has suffered from ulcerative colitis for 2 years and taken oral mesalazine daily. He was also diagnosed with diabetes mellitus 6 months ago, and his blood sugar levels have been well controlled by metformin. There was no history of allergies to food or drugs. He fasted for more than 8 hours before surgery and was given no sedative or opioid premedication.\nWhen arriving at an operating room, the patient was monitored with an electrocardiogram, a non-invasive arterial blood pressure monitor and a pulse oximeter. Anesthesia was induced intravenously with thiopental sodium 350 mg, following preoxygenation with 100% oxygen. After confirming the loss of consciousness and self respiration, we mask-ventilate the patient with oxygen. Mask ventilation was performed without difficulty, and he did not show any signs of airway irritation including cough. Vecuronium 10 mg was given for neuromuscular block, and then fentanyl 100 µg was administered. After a few seconds after the injection of fentanyl, the patient began to cough suddenly and vigorously. Coughing has persisted for about 30 seconds until he vomited a large volume of greenish fluid around the face mask. His head was immediately turned to the left and head down tilt of the table was applied. When vomiting ceased, after suctioning of the oral cavity and oropharynx, endotracheal intubation was achieved. During this episode, the arterial oxygen saturation transiently decreased to 93%, but soon recovered to 98%. Anesthesia was maintained with sevoflurane and 50% oxygen in air. A nasogastric tube was placed, and nearly 100 ml of bile-stained gastric fluid was drained. A small amount of greenish fluid was aspirated out of the endotracheal tube. Then, the surgery started with the patient in the right lateral decubitus position. After peritoneal insufflation with carbon dioxide (CO2), the peak inspiratory pressure increased from 21 to 26 mmHg. His arterial oxygen saturation has gradually fallen from 98 to 92% since the introduction of CO2. Although no more gastric fluids or secretions were suctioned through the endotracheal tube, a coarse crackle was heard throughout the right lung field on auscultation. The patient was placed on 100% oxygen and positive end-expiratory pressure of 5 mmHg was applied. The arterial oxygen saturation rose to 95%. An arterial blood gas analysis, checked at this time on a FiO2 of 1.0 and an ETCO2 of 37, was as follows: pH 7.334, PaO2 82.2 mmHg, PaCO2 44.2 mmHg, bicarbonate 24.9 mEq/L and SaO2 95.4%. Surgery proceeded uneventfully and vital signs were stable during the operation. The total anesthetic time was 255 minutes and blood loss was estimated at 300 ml. The patient was transferred to the intensive care unit and his arterial oxygen saturation which ranged between 93 and 95% with mechanical ventilation with a FiO2 of 1.0. Chest radiography taken postoperatively has shown patchy consolidation at the right lower lung field and decreased volume of the right lung, suggestive of pulmonary aspiration and atelectasis (). Fiberoptic bronchoscopic examination revealed a large amount of bile-stained fluid and some undigested food particles around the trachea, right main bronchus and lower lobar bronchi, which was aspirated and removed. The arterial oxygen saturation increased to 99-100% thereafter. His body temperature rose to 38.6℃ and antimicrobial therapy was initiated. Suction through the endotracheal tube and chest percussions were also frequently applied. On the next day, his temperature dropped to 36.5℃ and a radiologic improvement on the chest X-ray was observed. The patient was extubated and transferred to a general ward. Supplemental oxygen was delivered via the nasal prong at a rate of 3 L/min. He did not complain of dyspnea, productive cough or purulent sputum any more. Over the ensuing five days, mild cough and sputum left over were relieved, the arterial hypoxemia resolved and pulmonary infiltration was much improved (). The patient was discharged home seven days after surgery.