Giant orbital oncocytoma
A 19-year-old male from Papua New Guinea (PNG) presented with the long-standing complaint of left-sided proptosis which had slowly progressed over a period of 10 years. Visual acuity was preserved although lid retraction due to the degree of exophthalmos was causing exposure keratitis which could become sight-threatening. Computed tomography (CT) scan of the brain and orbits in PNG identified the cause to be a large soft tissue mass which was retro-ocular but entirely confined to the left orbit. The patient could not be treated in PNG and was subsequently referred to a tertiary hospital in Melbourne, Australia, for further assessment and specialist surgical treatment. On clinical examination, visual acuity was found to be 6/12 in the left eye and 6/5 in the right eye. Range of movement in the left eye was well preserved with very slight limitation of upward and downward gaze []. The cranial nerves were intact, Humphrey visual field testing revealed no deficit, and fundoscopy was unremarkable with normal appearances of the optic discs bilaterally.\nMagnetic resonance (MR) imaging of the brain and orbits demonstrated the lesion to be non-enhancing, multi-cystic, both intra- and extra-conal and infiltrating the left superior and inferior rectus muscles. The optic nerve was displaced by the mass but there was no radiological evidence of intracranial extension [Figures and ]. The most likely diagnosis based on the radiological findings was lymphangioma, oncocytoma was not considered. Surgical excision of the lesion was indicated to correct proptosis, reverse the corneal irritation, preserve vision and to obtain histology. Due to the retro-ocular location of the lesion, the planned approach was via a left fronto-orbitozygomatic craniotomy to maximize access and reduce the likelihood of injury to the globe and associated structures.\nIntraoperatively, the cystic mass was found to be diffusely infiltrating the superior and inferior recti, with no plane between tumour and normal tissue. Identification of the divisions of the oculomotor nerve and the abducens nerve was impossible due to the grossly distorted orbital anatomy and infiltrating tumour. The intraconal portion of the lesion was adherent to the optic nerve, displacing it laterally. The cystic elements containing a milky, turbid fluid were opened and the intraconaltumour was extensively debulked. A sub-total excision of the lesion was obtained.\nPost-operatively, there was initially significant periorbital swelling which improved rapidly. Formal ophthalmological review 11 days post-operatively revealed a dramatic improvement in the degree of exophthalmos although there was a complete ptosis possibly indicating deficit of the superior division of the oculomotor nerve, as well as a complete left lateral rectus palsy. Visual acuity remained unchanged.\nAt 1-month post-operatively, the previously noted ptosis and ophthalmoplegia remained unchanged with mild intortion of the eye in a resting state although acuity remained preserved. Delayed surgical correction of the ptosis and strabismus may be indicated in the future.\nHistological findings demonstrated fibrous connective tissue with multiple cystic spaces lined with a bi-layered cuboidal epithelium. Some fragments of normal lacrimal gland were also identified. The histological features were felt to be most consistent with a benign cystic oncocytoma, arising from the lacrimal gland [].