Ranibizumab in patients with dense cataract and proliferative diabetic retinopathy with rubeosis
A 63-year-old Hispanic male with a 2-year history of type 2 insulin-dependent DM. His medical history was significant for coronary heart disease, hypercholesterolemia, and hypertension. His DM had led to bilateral foot ulcers and left hallux amputation 3 months prior to enrollment. He was recruited into the study with NVI extending from 5.30 to 10 o’clock, a dense cataract, and PDR without traction retinal detachment on ultrasound. His NVI regressed 2 weeks after the first ranibizumab injection. No PDR was noted on retinal examination after the cataract surgery at the month -1 visit. However, NVD and NVE were noted at follow-up visits at months -5 and -9. (The detailed course of treatment has been described in the earlier section.) The ETDRS BCVA improved from 20/160 at baseline to 20/50 at month -2 and was 20/63 at month -12. The ocular examination remained stable after retreatment at month -9 with no recurrence of rubeosis through month -24.