Xanthogranulomatous Endometritis: An Unusual Pathological Entity Mimicking Endometrial Carcinoma
Herein, we report a case of a 45-year-old multigravida who presented with the complaints of continuous bleeding per vaginum for last 3 months with irregular menstrual history for 1 year. Per vaginal examination showed bulky retroverted uterus with clear bilateral fornices and healthy cervix and vagina. Laboratory investigations showed leukocytosis and low hemoglobin (8.0 gm %). On ultrasonography, she had a bulky uterus with slight thickening of anterior wall. Endometrial thickness was 12 mm. With these findings, clinical diagnosis of endometrial hyperplasia/carcinoma was made. Subsequently, she underwent fractional curettage. Grossly, we received multiple soft tissue pieces together measuring 1.5 × 1.0 × 0.5 cm. Hematoxylin and Eosin (H and E) stained sections showed proliferative endometrial glands with loose and edematous stroma, along with numerous histiocytes having foamy cytoplasm, lymphocytes, plasma cells, and areas of hemorrhage [Figures -]. No evidence of malignancy was present. Serological marker for carcinoembryonic antigen was measured to exclude malignancy. Special stains for bacteria, acid-fast bacilli (AFB), and fungi were negative. With the above findings, histological diagnosis of XE was made. Patient is currently under regular follow-up.