Aromatase inhibitors in male sex
A 15-year-old male presented with macromastia. He had delayed puberty.\nWt - 62.7 kg; Ht - 155 cm; Sexual Maturation Rate (SMR) - G1P1, testes - 3 ml, stretched penile length (SPL) - 5 cm.\nLH - 6.3 IU/L, follicle-stimulating hormone (FSH) - 2.9 IU/L, prolactin (PRL) - 5.1 ng/ml, normal thyroid-stimulating hormone (TSH) and T4.\nTestosterone (T) - 43.8 ng/dl and estradiol (E2) - 9.79 pg/ml. T/E2 = 4.4:1. He was prescribed letrozole 2.5 mg - 3 times/week.\nAfter 6 months of AI therapy:\nWt - 68.8 kg; Ht - 158.5 cm; SMR - G3P3, testes 10 ml, SPL - 6 cm. There was insignificant change in breast enlargement.\nT - 331.62 ng/dl; E2-8.05 pg/ml. T/E2 = 41.2.\nThere was 650% increase in T and 17.9% decrease in E2.