Angelman syndrome in three biological siblings: Focusing on the neuropsychiatric domain
An 8-year-old girl, the elder sister of the above, also had similar history of delayed milestones (social, motor, language and cognition), wide-based ataxic gait, since she learned walking with support. Always she used to remain happy and cheerful with frequent excessive, inappropriate laughter. There was no history of seizure, vision impairment, hearing loss, motor incoordination, and any extrapyramidal symptoms. Her social quotient (SQ) was found to be 15 on Vineland Social Maturity Scale, suggestive of profound MR.