Prolonged Delirium Secondary to Hypoxic-ischemic Encephalopathy Following Cardiac Arrest
A 59-year-old male was transferred from a general hospital to the tertiary psychiatric hospital in August 2011 after treatment of heart failure. He had been "healthy" and functioning well premorbidly and had multiple medical conditions such as hypertension, diabetes mellitus and hyperlipidaemia. He was first admitted to the cardiology unit of a general hospital in January 2011 after he collapsed during jogging. Following basic cardiac life support he was rushed to the emergency room of the general hospital. He was diagnosed to have acute myocardial infarction secondary to triple vessel disease and was arranged for coronary artery bypass surgery when his physical condition was stabilised. The electroencephalography and computerised tomography (CT) scans of the brain done on the day of admission in view of his fall were normal but the magnetic resonance imaging of the brain 10 days later showed mild generalized involutional change and disproportionate atrophy of basal ganglia and hippocampus. He regained full consciousness about 5 hours after the admission and was noted to have resting tremors and mild cogwheel rigidity before the administration of any psychotropic medications. He showed mild impairment in both retrograde and anterograde memory, which was greater for short term than long term memory. Subsequently, he was observed to have fluctuating conscious state and agitation but no localised motor or sensory neurological deficits. Laboratory investigations, which were performed including full blood count, renal, liver, thyroid function tests, and infective screen did not reveal any abnormalities. He was then discharged to a unit for cognitive rehabilitation in April 2011 and he was receiving oral haloperidol 2.5 mg daily for his agitation. For the next two months at the rehabilitation centre, he remained disoriented to time, place and person and can be emotionally labile at times.\nIn June 2011, he underwent his scheduled coronary artery bypass surgery. Intra-operatively he did not have any complications related to the surgical procedures or anaesthesia. However, postoperatively, he continued to be agitated and more disoriented to time, place and person, which persisted for the next 3 months. A month after his cardiac procedures, he was transferred to a residential facility for further cognitive rehabilitation and he was receiving oral haloperidol drops 3 mg daily for his agitation. He was subsequently re-admitted twice to a general hospital after he punched a nursing home staff on both occasions. In order to control his agitation, aggression and perceptual abnormalities, many antipsychotic medications were tried. His psychotropic medication was finally changed to olanzapine 2.5 mg daily as he exhibited extrapyramidal side effects attributable to the haloperidol and risperidone and orthostatic hypotension to quetiapine. The treating team also tried mood stabilisers but he developed adverse drug reactions such as maculopapular rash with lithium, sodium valproate and Steven Johnson syndrome with carbamazepine. As he also assaulted a staff nurse in the general hospital, he was transferred to a tertiary psychiatric hospital for further management of his neuropsychiatric condition.\nAt the psychiatric facility, his disorientation to time, place and person continued. He was agitated frequently, which needed rapid tranquilization and brief periods of minimal physical restraint for his safety. Formal cognitive assessment was attempted using Mini Mental State Examination (MMSE) and clock drawing test, but could not be completed owing to his uncooperative behaviour. The repeat CT scan of his brain revealed increased generalized volume loss of his brain. The nurses noted "sun downing effect" as he tended to become more disoriented and agitated towards the latter part of the day. He had impaired sleep wake cycle in that he was noted to be sleepy during the day time and more alert and disturbed at night. He also insisted on being only attended by female staff and even requested for alcohol in the ward although he was a teetotaller. As he continued to exhibit high risk of agitation, he was transferred to a high dependency psychiatric care unit for closer observation and management.\nDuring his four weeks' stay in the high dependency psychiatric care unit, he continued to have cognitive deficits in orientation, attention and concentration, memory which mainly worsened at night. Gradually his agitation responded to sulpiride 800 mg daily which was chosen due to the lower tendency for extra pyramidal symptoms. He could repeat sentences but was unable to recall the names of his close family members. Formal cognitive testing was attempted several times but to no avail due his uncooperativeness. Repeated laboratory investigations including full blood count, renal, liver and thyroid function tests, serum calcium and magnesium levels and cardiac enzymes were normal and his electrocardiogram showed sinus rhythm with left ventricular hypertrophy. Since his cognitive functions did not improve, he was referred to a psycho-geriatrician and subsequently transferred to the psychogeriatric ward for further management.\nIn the psychogeriatric ward, his clinical status remained the same for another few months. Nine months after the index cardiac event, the delirious features including disorientation to place and person, impaired attention and concentration, altered sensorium, perceptual disturbances such as visual and auditory hallucinations, emotional lability and psychomotor disturbances slowly improved. The altered sensorium, perceptual and psychomotor disturbances finally completely resolved with residual short term and long term memory deficits. He needed assistance for all his basic activities of daily living including toileting and feeding. He became more cooperative with the formal cognitive testing scoring 14 out 30 on MMSE. Input from the multi-disciplinary team involving psychiatric nurses, occupational therapist, physiotherapist, speech therapist and psychologist was sought to manage and improve his functional status. His social issues were addressed by the medical social worker. He was also reviewed by the visiting geriatrician on a regular basis for the management of his underlying medical conditions and he was prescribed clopidogrel 75 mg daily, frusemide 20 mg daily, perindopril 2 mg daily, simvastatin 40 mg daily and gliclazide 20 mg daily for his medical conditions. Overall, he was diagnosed with dementia which was secondary to cardiac arrest related HIE and complicated by prolonged delirium-which started following the incipient episode of cardiac arrest in January 2011 with further exacerbation after the cardiac bypass surgery. The other possibility of depressive episode resulting in cognitive deficits such as "pseudo dementia" was ruled out, as there was no clinical evidence to suggest a depressive episode that preceded the cognitive disturbance in this patient.\nAt the time of writing this case report, the patient still remained confused with significant impairment in short term and long term memory, although there was no fluctuation in consciousness or perceptual abnormalities. He needs assistance in all his basic activities of daily living and he displays aggressive behaviour in the ward on and off.