Genetic alterations in syndromes with oral manifestations
A male patient aged 10 years with mental retardation reported to our out-patient department with the chief complaint of decayed tooth. Extraoral examination revealed brachycephaly, oblique palpebral fissure, depressed nasal bridge, short neck, and gap between toes, short broad hands with simian crease and lip incompetence [Figure –].\nIntraoral examination revealed a high arched palate with crowding of teeth [], and macroglossia. These phenotypical features were analyzed and were found to have complete manifestations of Down's syndrome such as abnormal facial and skeletal features[] and mental retardation.[]