Radical vaginal trachelectomy at 16 weeks' gestation: A case report
A 27 year old nulliparous woman presented in November 2008 with a 2 month history of intermenstrual/postcoital bleeding. All previous smears were negative and she is a non-smoker. Clinically on examination there was a 2 × 2.5 cm exophytic lesion on the anterior lip of the cervix. Biopsy taken was inconclusive but suggestive of severe cervical glandular intraepithelial neoplasia (CGIN). The patient was subsequently seen in colposcopy clinic in December 2008 and a superficial LLETZ (12 × 10 × 8 mm) was performed which revealed a moderately differentiated adenocarcinoma of the cervix (10 mm horizontal width × 5 mm depth), incompletely excised, with lymphovascular space invasion (LVSI). The patient was then referred to a cancer centre with the expertise to perform fertility-sparing surgery.\nAt the cancer centre review the pathology and MRI of the pelvis were suggestive of stage 1b1 cervical cancer with a suspicious right obturator node. An endovaginal MRI pelvis was performed in order to obtain the following two measurements to determine that the correct cervical length was excised: the endocervical canal measured 2 cm and the length from the internal os to the top of the uterine cavity 4.2 cm. At the time of referral the patient was not pregnant and detailed counselling of the patient and her partner not only included the standard treatment but also fertility-sparing surgery. They were warned about the risks of prematurity but also the need for completion treatment by chemoradiation.\nIn January 2009 the patient underwent a laparoscopic pelvic lymphadenectomy and all 39 nodes were negative. At that time the pregnancy test was negative. In February 2009 a radical vaginal trachelectomy was scheduled but on the morning of her operation the pregnancy test was positive despite having used condoms for contraception. The first day of her last period was 28/12/08.\nThe case was re-discussed at the weekly multidisciplinary meeting and the following options were discussed:Termination of pregnancy would delay the subsequent procedure of radical vaginal trachelectomy for there would be a 6 week interval to allow for healing and resolution of artefact. This would defeat the purpose of preserving fertility and against the wishes of the couple. Radical vaginal trachelectomy during second trimester. A glandular tumour with positive margins requires removal of the endocervical canal in its entirety i.e. up to the isthmus. This is associated with an increased risk of rupturing membranes and thereby miscarriage at the time of the procedure. Obstetric advice was sought and by performing the procedure during the second trimester would minimise the risk of miscarriage associated with the first trimester. Neoadjuvant chemotherapy which would be implemented during the second trimester to avoid the greater teratogenic risk of treatment in the first trimester.\nAt 16 weeks' gestation a radical vaginal trachelectomy was performed and the specimen measured 40 mm × 40 mm × 38 mm. The maximum tumour dimension was 32 mm in addition to a tumour dimension of at least 10 mm in the LLETZ specimen. There was no evidence of LVSI in the trachelectomy specimen though it was evident in the LLETZ specimen. The anterior margin was close to the resection margin. The lateral and distal margins were well clear as was the proximal isthmic margin. By reviewing the reports in order to reconstruct the cervical cancer and estimate the size of the tumour, the conclusion reached was a diameter of 42 mm The final stage was stage 1b2 moderately differentiated adenocarcinoma of the cervix.\nIn an attempt to prevent uterine contractions a prophylactic nifedipine patch was administered at the time of the procedure and continued for a further 24 h. There is a significant risk of preterm labour in this group and an empirical course of erythromycin 250 mg qds was administered for 10 days and repeated at 24 weeks. Elective steroid administration was administered at 24 weeks' gestation to accelerate foetal lung maturity. Bed rest was preferable at home rather than a prolonged hospital stay between 22 and 26 weeks. At 25 weeks' gestation she had ruptured her membranes and was admitted to her local hospital for conservative management with monitoring of inflammatory markers and received a course of antibiotics. The patient was admitted 10 days following rupture of membranes with an antepartum haemorrhage. However, there was clinical and biochemical evidence of chorioamnionitis and she underwent an emergency classical caesarean section. A live female infant weighing 830 g was delivered at 26 weeks' gestation with Apgar scores of 6 and 10, at 1 and 5 min, respectively. Neonatal complications included respiratory distress syndrome, chorioamnionitis, and necrotising enterocolitis. The infant was discharged at a corrected gestational age of 36 weeks weighing 2440 g.\nAt 3 months postpartum the patient underwent a staging examination with multiple random biopsies. There was no evidence of disease recurrence either clinically, radiologically, or histologically. It is now 46 months following primary treatment for cervical cancer and there is no evidence of recurrence as assessed clinically and radiologically.