Primary cutaneous anaplastic large-cell lymphoma - Case report
A woman, aged 57, female, from Campina Grande-PB, has had skin lesions since 2001. The\nlesions began as eczema located in upper and lower limbs that have evolved to a\nwidespread scaly and quite pruritic rash with papules and nodules which ulcerated and\nspontaneously regressed, leaving permanent hypochromic stains ( and ).\nShe did outpatient treatment with a specialist since the onset of disease, but she only\nreceived a definitive diagnosis in 2007 (after six years of evolution). Until the\ndiagnosis, she had been given oral antihistamines and topical steroids, without\nimprovement. She also needed hospitalizations for secondary infections.\nShe underwent three skin biopsies (in 2004, 2006 and 2007); the first two were not\nconclusive.\nThe lesion biopsy performed in 2007 showed infiltration of atypical lymphoid cells of\nmedium and large sizes in the superficial and reticular dermis and in the subcutaneous\ntissue with significant eosinophilia ()\nsuggesting the creation of a immunohistochemical panel for cancer that was positive for\nCD30 , CD3 and CD15 markers and negative for Ki67 and ALK.\nAs for the diagnosis, tomography of the chest showed several nodules scattered\nthroughout the parenchyma of both lungs ().\nTreatment was initiated with methotrexate in weekly doses and achieved good clinical\nresponse.