Primary neuroendocrine carcinoma of breast with liver and bone metastasis detected with fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography
Here we describe a case of a 45-year-old female patient who presented with jaundice and was evaluated to have multiple liver lesions and biopsy from liver showed metastatic neuroendocrine tumor. Her chromogranin level was 886 ng/ml (normal < 78 ng/ml). She was referred for the whole body PET/CT for detection of the primary site. PET/CT showed an intense uptake in the soft- tissue necrotic lesion in the inner quadrant of the left breast [Figure and ] with the same charecteristic feature of multiple hypodense liver lesions []. Furthermore uptake noted in a lytic lesion in the D4 vertebra [Figure and ]. Patient underwent fine-needle aspiration of the breast lesion, which confirmed neuroendocrine origin [Figure and ]. A diagnosis of primary NEC of the left breast with metastasis was made and she was treated with peptide receptor radionuclide therapy and is on follow-up now.