Giant cell glioblastoma in the pediatric age group: Report of two cases
A 10-year-old girl presented with history of two episodes of focal seizures with secondary generalization in the last 6 months and with recent onset headache and vomiting from last 10 days. On examination, the patient did not have any focal neurological deficit. Magnetic resonance imaging (MRI) brain revealed a mass lesion in the right temporo-parietal region, hypointense on T1 and hyperintense on T2 with ring enhancement on contrast administration. It was associated with perilesional edema and mass effect. The radiological features were suggestive of high grade glioma []. The patient underwent right temporo-parietal craniotomy and gross total excision of the tumor. She had an uneventful peri-operative course and was discharged on 7th post-operative day. Histopathological examination was suggestive of GCG. MIB-1 labeling index was 10%. The patient received post-operative radiotherapy and chemotherapy including temozolamide. She was well for 27 months before she was lost to follow-up.