A Case of Idiopathic Anaphylaxis Followed by Acute Liver Injury
A 36-year-old woman was admitted for evaluation due to recurrent anaphylaxis. Three days before her hospital visit, the patient drank about 2,000 mL beer because of heavy stress. Normally she drank 1,500-2,000 mL beer twice a week. Two days later, she ate fried chicken for lunch and after 1-2 hours generalized urticaria and lip swelling developed, accompanied by dyspnea and light-headedness. However, there was no loss of consciousness. The patient recovered after a few hours of rest, although pruritus and general weakness remained. The following day, the patient underwent blood tests at a local hospital and marked elevations in her aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were noted. When the patient arrived at the hospital, her blood pressure was 110/70 mmHg and urticaria with pruritus observed. She was treated with an antihistamine and steroids and referred to the emergency department at our hospital for further evaluation.\nThe patient had experienced five similar episodes in the past. The first episode occurred 10 years previously. At that time, the patient was suffering from stress brought on by overwork. The next day, 3 or 4 hours after eating black bean sauce with noodles, the patient developed generalized urticaria, lip and periorbital swelling, and nausea. At the same time, her throat felt constricted and she was short of breath. She recovered after treatment in the emergency department; however, it was difficult to determine the exact therapeutic regimen. The second episode occurred 3 years later. Generalized urticaria, lip swelling, and dyspnea developed after eating chicken stew. When the patient visited the emergency department of another hospital, her serum aminotransferase levels were between 1,000 and 2,000 IU/L and she was admitted. She was negative for hepatitis virus markers, and an abdominal ultrasound detected no abnormal findings. Her serum aminotransferase levels quickly dropped below 200 IU/L over the following week and she was discharged. About a month later, at a follow-up visit, her serum aminotransferase levels had returned to normal values. The third and fourth episodes, which occurred 3 years ago and 7 months ago, respectively, were similar except that neither was associated with specific foods. Worthy of note is that during the fourth episode, which was treated at another hospital, it was initially suspected that her blood pressure was low. In both the third and fourth episodes, her serum aminotransferase values rose to 5,000 IU/L and then improved rapidly. The fifth episode occurred 6 months ago after the patient ate noodles. These episodes had increased in frequency over the past year from approximately once every 3 or 4 years to twice a year.\nThe patient had no history of bronchial asthma or drug or food allergies. She also had not been taking any medicine or herbal supplements for several months. Her family history was unremarkable. The patient was a married housewife who had a regular menstrual cycle. She had been living in urban areas and had never had pets.\nAt the present admission, the patient was alert. Her blood pressure was 145/87 mmHg, and her other vital signs were normal. Neither urticaria nor angioedema was present because they had already resolved. Her abdomen was soft, without tenderness, distension, or organomegaly. Laboratory testing revealed that her complete blood count and differential were normal without peripheral eosinophilia (white blood cell, 9,400/µL; total eosinophil count, 47/µL). Her serum creatinine level was normal, and her blood glucose concentration was mildly elevated (177 mg/dL). In addition, her AST and ALT levels were markedly elevated (681 and 1,337 IU/L, respectively). Her levels of alkaline phosphatase, gamma-glutamyl transpeptidase, and lactate dehydrogenase were also elevated to 122, 129, and 339 IU/L, respectively; however, there was no hyperbilirubinemia. Serological analyses for hepatitis A, B, and C viruses and tests for autoantibodies such as anti-nuclear antibody, anti-mitochondrial antibody, and anti-liver kidney microsomal type 1 antibody were all negative. Furthermore, her serum ceruloplasmin level was normal. Serum tryptase and histamine or its urinary metabolites were not measured. Testing for metanephrine or catecholamines and other hormonal studies was not performed because of a low probability of pheochromocytoma or carcinoid syndrome. Abdominal computed tomography demonstrated mild periportal edema of the liver. There was no evidence of abnormal focal lesions in the liver or biliary dilatation. A liver biopsy was not performed.\nInitially, we suspected food-induced anaphylaxis, specifically wheat-induced anaphylaxis, because the intake of wheat-containing foods was a common feature in several episodes. Although her total serum IgE levels were 297 kU/L (reference range ≤100), wheat-specific IgE antibodies were not detected. Moreover, a skin prick test with a large panel of commercial extracts of food allergens, including wheat, returned negative results. The skin panel also contained extracts of apple, banana, grape, orange, peach, pineapple, tomato, beef, cabbage, carrot, celery, chicken, chicken egg, milk, codfish, crab, lobster, shrimp, oyster, peanut, walnut, hazelnut, and mushroom (Allergopharma, Reinbek, Germany). The skin test results were confirmed by a multiple allergen simultaneous test (Advansure Allergy Screen, LG Life Sciences, Seoul, Korea). In addition, when an oral provocation test with noodles was performed under controlled conditions and monitoring, no reaction was observed over the course of 1 hour. The patient then underwent a 20-minute exercise challenge test. The patient experienced no symptoms either during or after exercise, which suggested that the attacks were not caused by wheat or exercise. No association between the previous episodes and foods, medications, or other triggers could be identified.\nHer AST and ALT values improved rapidly without specific treatment, and on day 5 of her hospital stay her values were 40 and 258 IU/L, respectively (). Self-injectable epinephrine was prescribed and the patient was discharged.