Cutaneous neonatal lupus with cutis marmorata\ntelangiectatica congenita-like lesions
A 3-month-old female infant born at term showed erythematous and scaly lesions on the\nface after photoexposure at 4 weeks of life. At 2 months, she showed marble-like,\nslightly infiltrative erythematous, purpuric lesions, which resembled CMTC lesions, on\nthe limbs ( and ). Histopathological analysis of the lesions on the limbs showed\nchronic lichenoid interface dermatitis, acantholysis, spongiosis, and vacuolization of\nthe basal layer, which was highly suggestive of cutaneous lupus (). The results of anti-Ro autoantibody analysis were\npositive for both the patient and her mother, confirming the diagnosis of neonatal\nlupus. The results of haematologic screening involving blood cell count and erythrocyte\nsedimentation rate (ESR), hepatic screening involving liver function and liver enzyme\nanalysis, and cardiological testing involving electrocardiography and echocardiography\nwere normal.\nThe treatment of lesions was only preventive, avoiding sun exposure, which caused\nregression of lesions at 7 months without scarring. The patient's mother was\nasymptomatic at the time of pregnancy, with an ESR of 116 mm/h, a fine speckled\nanti-nuclear antibody pattern, and an ANA titre of 1:640. Therefore, she was instructed\nto ensure outpatient follow-up because of the possibility of developing connective\ntissue diseases.