Sunitinib Treatment for Metastatic Renal Cell Carcinoma in Patients with Von Hippel-Lindau Disease
A 49-year-old male patient was diagnosed with RCC in the right kidney five years ago and underwent radical nephrectomy of that kidney. Pathology of the sample revealed clear cell RCC. At that time, the patient was also found to have hemangioblastoma in the right retina and the cerebellum and was diagnosed with VHL disease. On surveillance chest CT, multiple lung and pleural metastases were found. The patient was treated with sunitinib (50 mg, four-week treatment with a two-week rest period) and achieved partial response according to RECIST criteria four months after treatment with sunitinib (), which lasted four years and three months. Follow-up chest CT showed disease progression and the patient's medication was changed to everolimus. After two months of treatment with everolimus, response studies showed further disease progression and the patient is now receiving supportive care without further chemotherapy due to poor general condition.