Aquagenic keratoderma. Two new case reports and a new hypothesis
The second patient was a 27-year-old male suffering from cystic fibrosis (CF) and focal palmar hyperhidrosis. He was tested positive for homozygosity for the ΔF508 mutation of the CF transmembrane conductance regulator (CFTR) gene. His medication consisted of macrolide antibiotic prophylaxis and inhaled corticosteroids. Without immersion in the water, he showed whitish translucent papules and increased wrinkling of the palms []. Symptoms worsened after water immersion. He did not report pruritus or pain sensation.\nWe treated him twice daily with a topical aluminum chlorohydrate emulsion (Ansudor N, Galderma). Palmar symptoms improved markedly.