Giant cell glioblastoma in the pediatric age group: Report of two cases
An 18-year-old male patient presented with focal seizure involving right upper limb since past 1 month and right-sided hemiparesis. Neurological examination revealed right-sided hemiparesis with a power of 4/5 (Medical Research Council grading). MRI brain revealed a mass lesion in the left frontal region; hypointense on T1, hyperintense on T2, and FLAIR images with inhomogenous post-contrast enhancement []. It was associated with perilesional edema and mass effect. The patient underwent left fronto-parietal craniotomy and gross total excision of tumor. He had an uneventful peri-operative course and was discharged on 7th post-operative day. Histopathological examination was suggestive of GCG. MIB-1 labeling index was 25%. The patient received post-operative radiotherapy and chemotherapy including temozolamide. He was well for 30 months when he had a recurrence of tumor in frontoparietal region and died 1 month later.