Cutis Laxa: A Report of Two Interesting Cases
A 40-year-old Muslim male presented to us with a complaint of loose skin all over his body for last 10 years. He was well till the age of 30, when he noticed that his skin was gradually becoming wrinkled and loose. It started from forehead and progressed slowly downwards over a couple of years after that the process stabilized. At the time of presentation, he was suffering from hypertension and cervical and lumbar spondylosis. He was having beta-blockers for hypertension. He had no episodes of dyspnoea, chest pain or palpitations. His family history was non-contributory. On examination, the patient appeared much older than his age. The skin of his forehead [], neck, abdomen and back [] was diffusely wrinkled and it hung in folds. There was blepharochalasis but no hyper-extensibility of joints. Eye examination did not reveal any angioid streaks.\nIn both the cases investigations revealed normal values for complete blood count, erythrocyte sedimentation rate, routine urine analysis, blood biochemistry, hepatic enzymes and serum electrophoresis. Chest X-ray, electrocardiography and gastroscopy were normal. Biopsy specimens taken from the involved area were stained with Hematoxylin-eosin (H and E), Von Kossa and Verhoeff-van Gieson stain. Histopathological findings were similar in both cases. H and E staining revealed normal epidermis with diminished elastic fibres and mild non-specific chronic lymphohistiocytic infiltrate in upper dermis []. The elastic fibres present were fragmented, stained uneven and showed granular appearance, as evidenced in Verhoeff-van Gieson stain []. Von-Kossa stain did not show any calcification.