Ranibizumab in patients with dense cataract and proliferative diabetic retinopathy with rubeosis
A 70-year-old Hispanic female with an 11-year history of insulin-dependent type 2 DM, an 11-year history of hypertension controlled with medications, and a 4-year history of chronic kidney disease and diabetic nephropathy. Rubeosis was noted to have resolved 4 days after the first injection. There was no recurrence of NVI or PDR seen during subsequent study visits. Notably, she was hospitalized at month -11 for bilateral pedal edema and dyspnea. She was treated for CHF exacerbation and pulmonary edema with intravenous steroids and diuretics, and also for an exacerbation of her pre-existing chronic kidney disease. The ETDRS BCVA improved from 20/400 at baseline to 20/63 at month -2, 20/25 at month 7, 20/23 at month -12.