Anticonvulsant hypersensitivity syndrome associated with carbamazepine administration: Case series
A 50-year-old male patient was suffering from trigeminal neuralgia and was on tablet carbamazepine 300 mg once a day for last 1 week. He developed reddish-colored skin lesions all over the body, spreading into oral cavity with fever after 8 days of starting the treatment. He was suspected of having drug reaction and referred to department of skin and venereal diseases of Dhiraj hospital, Piparia. On clinical examination, skin lesions were present all over the body with itching and fever []. The lesion appeared first in oral cavity and spread to the trunk and extremities. He was diagnosed as having maculopapular eruptions due to carbamazepine. Blood investigations revealed WBC count 6300/mm3, neutrophils 78%, lymphocytes 15%, urine albumin 3+ and SGPT 60 IU/l, suggestive of liver and kidney involvement. Tablet carbamazepine was stopped immediately and he was given oral prednisolone 30 mg once a day for 1 week and tapered by 5 mg per week along with injection pheniramine maleate 4 mg intramuscularly. He was on regular follow-up with good improvement in his clinical condition.