Adenoid Cystic Carcinoma of the Breast: A Case Series of Six Patients and Literature Review
A 49-year-old female presented with a palpable mass in her right breast, which she had discovered one year earlier. Mammography and breast US showed a poorly defined mass measuring 3.0×2.5 cm in the right upper breast and thickening of the overlying skin. The patient underwent MRM and ALND. Histopathologic examination revealed an ACC measuring 4.5×3.7×2.5 cm and no metastatic lymph nodes (pT2N0M0). The tumor consisted of 50% solid component in addition to necrosis and infiltrative invasion. IHC was negative for expression of ER, PR, and HER2. The patient underwent six cycles of adjuvant chemotherapy using FAC. She was free of disease for 45 months, and was then seen with thickened, reddish skin at the previous surgical site. Results of a skin biopsy indicated recurrent ACC. Local excision was performed, followed by a wide excision and postoperative radiotherapy, because the posterior and lateral resection margins were involved with the tumor. No recurrence has been detected during 52 months of follow-up.