Primary pulmonary rhabdomyosarcoma in children: Report of three cases with review of literature
A female child aged 9 years, presented to hospital elsewhere with fever, cough, and hemoptysis for 2 months and decreased breath sounds in the right infra-axillary area. She was found to have mass lesion in the apical segment of right lower lobe by chest X-ray [] and CT scan []. Patient underwent right thoracotomy with segmentectomy of apical segment of right lower lobe. The histopathology revealed lung tissue with a tumor composed of compact spindle cells arranged in fascicles, cells showed moderate pleomorphism with an occasional mitosis. The dissected two mediastinal lymph nodes showed reactive changes. IHC revealed cells positive for desmin, MyoD 1, and focally positive for S-100, suggestive of embryonal RMS of spindle cell variant. The metastatic workup was negative. The patient received chemotherapy as per the IRS III protocol and was disease free for 19 months.