Neoadjuvant chemotherapy followed by fertility-sparing surgery for women with stage IB1 cervical cancer
A 29-year-old woman G0P0 was presented in November 25th 2005. In October 12th, she was admitted to local hospital with abdominal pain. The gynecologic physical examination revealed a tumor measured 2.5 cm×2.5 cm. Colposcopy and biopsy specimen showed squamous cell carcinoma of non-keratinizing type. In November, she was given one cycle chemotherapy (PF regimen: cisplatin 100 mg/m2, day 1; 5-fluorouracil (5-FU) 1,000 mg/m2, day 1-4). Repeat gynecologic physical examination showed no tumor and magnetic resonance imaging (MRI) showed no metastatic lymph nodes. In November 29th 2005, she underwent surgery. Laparoscopy pelvic lymphadenectomy was done first and the frozen section was negative. Then it was followed by VRT. The final histopathological examination revealed carcinoma in situ without evidence of invasive cancer. The 11 removed lymph nodes confirmed negative. The patient was followed up via gynecologic physical examination, colposcopy every month and positron-emission tomography each year. The patient is free of disease for 69 months. However, she has not attempted to conceive.