Cutaneous Lymphangiosarcoma Following Chronic Lymphedema of Filarial Origin
A 36 year old female patient had bilateral lymphedema following filarial infection since 20 yrs. She came with a complaint of fungating mass on left leg. To start with it was reddish nodule which progressed into a fungating mass within a span of 4 months.\nOn physical examination patient had extensive skin thickening and an fungating soft tissue mass measuring 10 cm × 7 cm in the medial aspect of the left leg [].\nA skin biopsy was performed which showed a tumor composed of numerous pleomorphic spindle cells lining the anastomozing blood vessels []. Focal areas of dystrophic calcification in the form of calcosphere were seen consistent with old filarial infection. On immunohistochemistry, tumor cells were positive for CD34, CD31, vimentin, and negative for Cytokeratin (CK) which confirmed our diagnosis of angiosarcoma.\nPatient undergone below knee amputation without any adjuvant therapy. The follow up of the patient till date show no evidence of recurrence or metastasis.