Aromatase inhibitors in male sex
A 14-year-old male was referred for obesity. He had delayed puberty.\nWt - 66.6 kg; Ht - 158 cm; SMR - G1P1, SPL - 4 cm.\nLH - 3.59 IU/L; FSH - 2.48 IU/L; PRL - 13.8 ng/ml, normal TSH and T4.\nT - 25.81 ng/dl; E2 - 141.3 pg/ml; T/E2 = 0.18:1.\nHe was prescribed injection T - 100 mg monthly and letrozole 2.5 mg - 3 times/week for 4 months. After 3 weeks of last dose of injection T and 3 days of last dose of letrozlole: Wt - 68.9 kg; Ht - 159.5 cm; SMR-G2P2, SPL ~5 cm.\nT - 310.6 ng/dl; E2 - 13.15 pg/ml; T/E2 = 23.6:1.\nThere was ~1100% increase in T and 90% decrease in E2.