Large Cell Calcifying Sertoli Cell Tumor of the Testis: A Case Study and Review of the Literature
A 24-year-old man was admitted to The Armed Forces Capital Hospital to investigate a left testicular mass, which had been incidentally detected in a plain radiograph taken for lower back pain (). There were no clinical signs of CNC or PJS. A left orchiectomy was performed, whereupon the testis was found to contain a 1.1-cm, well-demarcated, stony hard mass. On a cut section, this lesion had a grey-brown area with, whitish calcific changes and was confined to the testis ().\nMicroscopically, the tumor was composed of neoplastic cells, fibrotic stroma, and laminated or irregularly shaped calcific bodies, containing focal ossification. The tumor cells had abundant eosinophilic or clear cytoplasm, and were arranged in cords, trabeculae, clusters, and diffuse sheets (). An intratubular growth pattern was also apparent, along with thickening of the basal lamina of these tubules, and intratubular microcalcification (IMC) at the periphery (). The nuclei were round with one or two conspicuous nucleoli, and showed moderate degree of nuclear pleomorphism. No mitotic figures, necrosis, Reinke crystalloids, or lipofuscin pigment were present, and the fibrotic stroma appeared benign.\nImmunohistochemically, neoplastic cells were diffusely positive for S-100 protein (ready-to-use, anti-S-100 polyclonal antibody, Dako, Glostrup, Denmark), vimentin (ready-to-use, anti-vimentin monoclonal antibody, clone VIM 3B4, Dako), focally and weakly positive for inhibin alpha (ready-to-use, anti-inhibin alpha monoclonal antibody, clone R1, Dako) () but negative for cytokeratin (ready-to-use, anti-cytokeratin monoclonal antibody, clone AE1/AE3, Dako), CD10 (ready-to-use, anti-CD10 monoclonal antibody, clone 56C6, Dako), and Melan-A (ready-to-use, anti-melan-A monoclonal antibody, clone A103, Dako).