Renovascular Hypertension Treated by Renal Artery Embolization
A 9-year-old boy was referred to our hospital due to uncontrollable arterial hypertension. He was the second baby from twin gestation in a female who underwent in vitro fertiliazation pre-embryo transfer and was prematurely born at 30 weeks and 1 day gestational age with birth weight of 1580 gm. On the 10th day of admission in the neonatal intensive care unit, he presented with elevated blood pressure which was attributed to umbilical cord catheterization. Elimination of the umbilical catheterization and three-day medication with captopril led the high blood pressure to subside. Renal ultrasonography including Doppler interrogation revealed that the size of both kidneys was different from each other (right kidney 4.4×1.7 cm, left kidney 3.6×1.5 cm) and the renal blood flow was decreased in the left kidney. He was discharged with medication of hydralazine and captopril. Although he was recommended to regularly attend outpatient clinic, he was follow-up lost since then.\nSeven years later, he visited a local clinic due to repetitive epistaxis and was referred to the department of pediatric nephrology for the evaluation of uncontrollable hypertension, measuring between 220/100 and 140/90 mm Hg. 274On admission, his body weight was 25 kg (10th percentile) with a height of 132.9 cm (25-50th percentile), a pulse rate of 96 beats per minute, and a blood pressure of 120/75-122/85 mm Hg in all four limbs at rest. There were no abdominal or carotid murmur and no palpable masses in his abdomen. The clinical and neurological examination was normal. The echocardiography showed left ventricular hypertrophy with a left ventricular mass of 116 g/m2 (range, 70-80). The left ventricular function was normal with ejection fraction of 73%, and the aortic arch showed no abnormality. There was no evidence of aortic coarctation or no obvious diastolic dysfunction.\nBlood chemistry values including creatinine, sodium, potassium, and chloride were unremarkable. Additional endocrine tests showed normal values for thyroid hormones. The renin level was >20 ng/mL/hr (range, erect 1.9-6.0), aldosterone level of 44.84 pg/mL (range, 12-340 for age), cortisol level of 10.2 ug/dL (range, 3.1-12.7), vanillylmandellic acid level of 2.68 mg/day (range, 0.0-8.0), and homovanillic acid level of 5 mg/day (range, 0.0-8.0). Urinalysis was within normal limit without proteinuria, hematuria, and renal tubular dysfunction.\nIn abdomenal computed tomography (CT), the left hypoplastic kidney was observed, with narrow and tortuous left renal artery, indicating congenital left renal hypoplasia or secondary contracted left kidney (). On the captopril-primed diethylene triamine pentaacetic acid scan, the early uptake, perfusion, parenchymal transition time, and excretion were all delayed in the left kidney, as well as the decreased left kidney in size (). In contrast, all the values in the right kidney were normal.\nTaking a renal arteriogram, coil embolization was performed in the left two renal arteries. At the end of the procedure, another arteriogram confirmed the complete suppression of arterial flow to the left kidney (). While performing renal arterial embolization, blood was sampled in both renal veins to measure renin levels again. The renin levels in the right and left renal veins were 6.67 ng/mL/hr and above 20 ng/mL/hr, respectively. After the procedure, there was no uptake in the left kidney on dimercaptosuccinic acid (DMSA) scan, showing complete occlusion of the left renal artery (). The embolization caused mild pain in the left flank and slight fever in the patient, which were resolved in one week. Before discharge, we remeasured renin level, and it was 6.76 ng/mL/hr. His blood pressure was maintained between 125/75 and 135/85 mm Hg, and he was discharged with oral medication (amlodipine 5 mg q.d. and angiotensin receptor blocker 50 mg q.d.) for one month.\nOne month later, his blood pressure returned to normal, 95/66-125/75 mm Hg. His renin and aldosterone levels were 7.71 ng/mL/hr and 23.94 pg/mL, respectively. Follow-up abdominal CT showed enhancement in the cortex of the left contracted kidney, suggesting collateral blood that supplies to the left kidney. However, his blood pressure was maintained in the normal range without any antihypertensive medications.