Familial steroid-sensitive idiopathic nephrotic syndrome: seven cases from three families in China
The first case was an 8-year-old girl who presented on March 3, 2004 with edema, massive proteinuria, and hypoalbuminemia that had persisted for seven days. The level of protein in a 24-hr urine sample was 3.42 g, and the blood albumin concentration was 14.5 g/L. Primary nephrotic syndrome was diagnosed, and treatment with 1.5 mg/kg/day of prednisone was initiated. Over time, the patient developed frequently relapsing nephrotic syndrome, and a renal biopsy performed in 2006 revealed minimal change disease (MCD). Subsequently, pulse cyclophosphamide (CTX) therapy was applied for four months at a total dose of 145 mg/kg CTX. The patient achieved remission and has since maintained this state.