Recurrent Stereotyped Episodes in Cerebral Amyloid Angiopathy: Response to Migraine Prophylaxis in Two Patients
A 74-year-old woman presented with 3 weeks of stereotyped episodes of tingling and numbness, starting in her right arm and spreading within minutes to contiguous body parts until the face, arm and leg were involved. She had had 5-7 events per day for 3 years. Exam was normal. EEG was normal. MRI showed subcortical hemosiderin deposits on gradient echo sequences (GRE) typical of CAA. Topiramate 25 mg twice daily terminated the attacks.