Transfusion-Associated HIV Infection in Pediatric Leukemia Patients (Two Case Reports)
Case 2: A 4-year-9-month old girl weighing 21 kg was admitted to hematology department of our hospital on December 8, 2009 because of 20 days of abdominal discomfort and anorexia. The initial CBC showed WBC 0.83×109/L, N 7.2%, Hb 90 g/L, Plt 202×109/L. The diagnosis was ALL (L2, common-B, low risk) according to the results of bone marrow cytomorphology examination, FCMI and CBC. During the first hospitalization from December 8, 2009 to January 22, 2010, she formally underwent chemotherapy. During the second hospitalization from February 16, 2010 to April 3, 2010, sequential chemotherapy was carried out. Totally, 2 U RBC, 5 U platelets and 1500 ml fresh frozen plasma were transfused during the two hospitalizations. During the third hospitalization, her blood test for HIV-Ab was positive [human immunodeficiency virus antibody diagnosis reagents (double antigen-binding enzyme-linked immunosorbent assay), INTEC (Xiamen) technology Ltd. LOT: 2010046607]. The result was also confirmed by CDC (HIV 1/2 Antibody Immunoblot Kit, MP Biomedicals Asia Pacific Pte. Ltd. Lot: AE9015). Later, tests of blood products transfused showed that the fourth RBC carried the HIV. There was no transfusion before her diagnosis of leukemia, no operation and infectious disease in her past history. Her history of vaccinations was normal. Her parents were healthy, and their blood sample was negative for HIV-Ab.