Gingival plasma cell granuloma
A 58-year-old woman was admitted in November 2010 who presented with an enlarging, painless mass in the oral cavity. The mass was present since five years and was slowly increasing in size. There was no history of trauma or surgery to the oral cavity. She had no systemic symptoms. On oral examination, the mass was polypoidal, nontender, firm measuring 3 × 2 cms and was located on the inner aspect of upper gingiva extending from right middle incisor to the left canine region. The mass did not involve the palate. Radiological examination and serum electrophoresis were normal. Routine laboratory examination was normal. The mass was excised and sent for histopathological examination.\nGrossly, the lesion was polypoidal and solid measuring 3 × 2 × 1.5 cms with smooth white cut surface []. Microscopically, the mass was lined by stratified squamous epithelium with focal ulceration. The mass was composed of nodular infiltrates of mature plasma cells admixed with lymphocytes and histiocytes on the background of loose myxoid and collagenized stroma showing scattered fibroblasts and myofibroblasts [Figures and ]. In areas, the lymphoplasmacytic infiltrate was prominent around the blood vessels. Russell bodies were also seen []. Mitotic figures or nuclear atypia were not seen. Immunostaining for kappa and lambda light chains revealed a polyclonal plasma cell population [Figures and ].