Neutralizing antibodies to botulinum neurotoxin type A in aesthetic medicine: five case reports
The patient in the fourth case study was a 43-year-old Caucasian woman who had received botulinum toxin type A for facial rejuvenation over a period of 8 years, starting in 2004. During this time she had received a total of 1,000 U of abobotulinumtoxinA (Dysport®) over eight injection sessions, with injection points in the frontalis, corrugator, procerus, orbicularis oculi, and platysmal bands (). For the first 3 years, the duration of effect lasted 6–8 months. However, after 2007, treatment effects could not be observed after 3 months. Results of antibody titers were high positive (++).