Generalized Dowling-Degos Disease: Case Reports
A 50-year-old woman, the younger sister of the patient in case 2, had progressively generalized skin lesions after puberty. Her skin lesions were very similar to his brother's lesions, with generalized reticulate hyperpigmentation, open comedo-like lesions and multiple pits of varying sizes on the face, perioral area, flexures and axillae. There was no history of inflammatory skin diseases prior to the onset of the lesion. There was no significant past medical, surgical and gynecological history. Skin examination revealed multiple pits of varying sizes distributed over the face, upper back, upper chest, arms, cubital fossa and over forearms. There was diffuse reticulate pigmentation over the cubital fossa, axillae, inguinal region and face. The rest of the skin examination was unremarkable. Her general physical examination and all relevant investigations were within the normal limit. We did not perform a genetic study in our patients due to their religious belief.