Morbihan syndrome
A 60-year-old Caucasian man was admitted to our Department because of a dermatitis on the face. The patient stated that he was in good general health, except for obesity (120 kg), and that he was not in therapy with systemic drugs. The patient also stated that the dermatitis appeared approximately 4 years before and that it was unsuccessfully treated with oral corticosteroids.\nDermatological examination revealed a severe erythematous edema involving the forehead, glabella and both eyelids, because of which the patient was not able to open his eyes completely. Furthermore, erythema and telangiectasiae were visible on the nose and cheeks [Figures and ].\nGeneral physical examination did not reveal anything pathological.\nAll laboratory and instrumental examinations (echography of periorbital area, carotids, and thyroid, chest X-rays, electrocardiogram, echocardiogram, and echography of the abdomen) were within normal ranges or negative.\nHistopathological examination showed dermal edema, perivascular and periadnexal lympho-histiocytic infiltrate, and sebaceous gland hyperplasia. No mast cells were observed.\nA diagnosis of Morbihan syndrome was made.\nThe patient was treated with oral isotretinoin [starting daily dosage: 0.5 mg/kg (=60 mg/day) for 4 weeks)]. Maintenance dosage was 0.5 mg/kg/day for 22 weeks. Only a mild increase in total cholesterol levels was recorded. No significant clinical improvement was observed.