Simultaneous renal clear cell carcinoma and gastrointestinal stromal tumor in one case
A 65-year-old man presented to PeKing Union Medical College Hospital (PUMCH) with a four-month history of weakness, anorexia, upper abdominal discomfort, and weight loss of 3 kg. A 64-spiral computed tomography (CT) scanning of the abdomen demonstrated the presence of a 5 cm × 5 cm × 4 cm left renal mass and 10 cm × 9 cm × 8 cm gastric mass [Figures -]. There were no metastases seen in the liver or lung. The patient underwent surgical resection with radical nephrectomy and partial gastrectomy. Histological appraisal of the specimens revealed a clear cell type Fuhrman grade 2 renal cell carcinoma and a gastrointestinal stromal tumor (GIST). All resection margins were clear of tumor and the GIST was positive for c-KIT and DOG-1. The patient was treated with sunitinib at a standard dose postoperatively (50 mg daily, 4 wk on, 2 wk off).