Angelman syndrome in three biological siblings: Focusing on the neuropsychiatric domain
A 5-year-old girl, younger sister of the above two also had complaints of difficulty in speech, poor comprehension, and communication ability, compromised ability to do the activities of daily living with history of global delayed developmental milestones and ataxic gait. There was no evidence of vision impairment, hearing, motor function, or history of seizure. She had microcephaly with an open mouth and protruded tongue. Her SQ was found to be 19 on Vineland Social Maturity Scale, suggestive of profound MR.