Linear Nevus Sebaceous Syndrome in a Neonate Conceived by Intracytoplasmic Sperm Injection
Full-term male neonate, conceived by ICSI, was born to a 21-year-old mother (gravida 1, para 1) at 39 weeks of gestation by caesarean delivery and resuscitation was assigned as uneventful. A prenatal sonogram at 32 weeks gestation revealed polyhydraminos as well as a well-defined hyperechoic mass 4.5×3 cm in the left lateral side of the face and neck with central cystic area.\nThe initial physical examination showed normal growth parameters with an evident cutaneous abnormality of the face consisted of linear, well-demarcated, raised, yellowish, fleshy and hairless plaques with velvety surface located on the left side of the forehead, the parietal region of the scalp, the face, chin, lower lip, and left ear with a smaller lesion on right side of face []. A similar, less well-formed lesion was present over the midline of the back at the lumbar and the sacral regions and scrotum. Also, a black nodule was noted over the medial canthus of the right eye. There were no other cutaneous manifestations, such as cafe-au-lait spots or hypo- or hyper-pigmentation lesions. The infant appeared healthy otherwise with no apparent neurologic deficit on physical examination.\nMagnetic resonance imaging (MRI) of his brain revealed an extra-axial CSF signal intensity lesion in the left side of the posterior fossa and the cistern magna suggesting arachnoid cyst with mild left cerebellar hypoplasia (Dandy Walker variant) []. Ophthalmologic examination showed bilateral posterior polar cataract. Abdominal sonogram, Doppler of renal vessels, bone survey and echocardiography revealed normal results. Also, serum calcium, phosphorus and urinary calcium were normal.\nHistopathology showed thick hyperplastic epidermis with underlying large immature sebaceous lobules and free cut margins with no evidence of cellular atypia.\nDuring hospitalization of the patient, no seizures occurred and no medication was prescribed. A chromosome study of peripheral blood showed a normal male karyotype.\nWritten informed consent was obtained from the parents of our patient for publication of this case report and any accompanying images. A copy of the written consent signed by the father of our patient is available for review by the Editor-in-Chief of this journal.