Mosaic epidermolytic ichthyosis - Case report
Female patient, 37 years old, has presented with blisters and erosions in her axilla,\ngroin, gluteal region and left flank since she was 3 months old. Lesions later became\nhyperkeratotic and verrucous. The patient has a healthy son without similar lesions. She\nreported no previous diseases, use of medication, previous hospitalizations, surgeries,\ndrug allergies or similar diseases in the family.\nOn examination, hyperchromic plaques with verrucous papules were observed in her axilla,\ngroin and gluteal region, following Blaschko's lines. Palmoplantar hyperkeratosis (-)\nwas also seen. All lesions were located in her left hemibody.\nThe patient underwent a biopsy procedure. Histopathologic examination revealed an\nepidermis with extensive foci of hyperkeratosis and parakeratosis, under which there\nwere hypergranulosis and vacuolar degeneration of the granular layer and the upper\nlayers of the stratum spinosum (). The\npattern described confirmed the clinical hypothesis of epidermolytic ichthyosis.\nThe patient was treated with topical retinoic acid with improvement of the lesions on\nthe trunk and persistence of the other lesions.