Multiple Familial Trichoepithelioma with Malignant Transformation
A 65-year-old male, the father of the first patient, was presented similarly by papulo-nodular lesions with the same distribution and morphology described in his daughter but larger in size []. These lesions appeared since 57 years but were neglected as they were asymptomatic. One month before reaching us, one of those nodules enlarged markedly to reach a size of 6 cm with repeated bleeding, ulceration and crustation [].\nExcisional biopsy was taken from a representative papule and incisional biopsy was taken from the enlarging nodule after taking patient consent.\nFor the former biopsy, examination of H and E-stained sections and immunohistochemical-stained sections of the same antibodies revealed the same results as the first case.\nFor the latter biopsy, islands of basaloid cells extending from the epidermis to the dermis with peripheral palisading and prominent stromal epithelial retraction artifacts were observed. Cells were large, with uniform large nuclei and scanty cytoplasm. So the diagnosis of BCC was suggested. Immunohistochemical staining revealed that, the basaloid cells stained diffusely with Bcl2 [], CD10 [] and focally with AR antibodies []. CD34 immunostaining was negative [].