Primary extraskeletal mesenchymal chondrosarcoma of the vulva
A 59-year-old woman was referred to gynecologic clinic with a diagnosis of the lipoma of the left vulva. She identified a small but growing mass before one month. A globular, movable mass measuring about 3 cm in diameter was palpated in the left major labium. The mass was excised with a 2 cm resection margin. Frozen section biopsy of the resected specimen demonstrated a chondrosarcoma with a negative resection margin. The final pathological report confirmed a 4×4×3 cm sized EMC of the vulva revealing no microscopic lesions on the resection margins. Tumor markers were within normal range (CEA, CA-19-9, CA-125, and AFP). Immunohistochemistry was performed on the tumor to analyze the expression of vimentin, S-100 protein, desmin, and EMA. The tumor was strongly positive for vimentin, but negative for the other markers. The patient recovered from surgery without any postoperative complications. Bone scans and chest radiographs for disease staging were negative. After twenty four-month of following-up, she did not present any recurrence as assessed by pelvic MRI and chest radiographs.