Primary extraskeletal mesenchymal chondrosarcoma of the vulva
A 68-year-old woman was referred to our clinic with a diagnosis of a mass of the vulva. The patient had noticed a small but growing mass on her right vulva which had been palpated one month earlier. On physical examination, a globular, movable mass measuring about 4 cm in diameter was palpated in the right major labium. The mass was excised with a 2 cm resection margin. Frozen section biopsy of the resected specimen demonstrated a chondrosarcoma with a negative resection margin. The final pathological report confirmed a 6 × 2.8 × 2.3 cm sized EMC of the vulva revealing no microscopic lesions on the resection margins (). Tumor markers were within normal range (carcinoembryonic antigen [CEA], CA-19-9, CA-125, and alpha fetoprotein [AFP]). Immunohistochemistry was performed on the tumor to analyze the expression of vimentin, S-100 protein, desmin, and epithelial membrane antigen (EMA). The tumor was strongly positive for vimentin and S-100 protein but negative for the other markers. The patient recovered from surgery without any postoperative complications. Bone scans and chest radiographs for disease staging were negative. Thirty months following from the initial diagnosis, the patient revealed no evidence of recurrence as assessed by pelvic magnetic resonance imaging (MRI) and chest radiographs.