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---
language:
- en
license: apache-2.0
library_name: transformers
tags:
- generated_from_trainer
- medical
datasets:
- opentargets/clinical_trial_reason_to_stop
metrics:
- accuracy
widget:
- text: Study stopped due to problems to recruit patients
example_title: Enrollment issues
- text: Efficacy endpoint unmet
example_title: Negative reasons
- text: Study stopped due to unexpected adverse effects
example_title: Safety
- text: Study paused due to the pandemic
example_title: COVID-19
base_model: bert-base-uncased
model-index:
- name: stop_reasons_classificator_multilabel
results: []
---
<!-- This model card has been generated automatically according to the information the Trainer had access to. You
should probably proofread and complete it, then remove this comment. -->
# Clinical trial stop reasons
This model is a fine-tuned version of [bert-base-uncased](https://huggingface.co/bert-base-uncased) on the task of classification of why a clinical trial has stopped early.
The dataset containing 3,747 manually curated reasons used for fine-tuning is available in the [Hub](https://huggingface.co/datasets/opentargets/clinical_trial_reason_to_stop).
More details on the model training are available in the GitHub project ([link](https://github.com/opentargets/stopReasons)) and in the associated publication (DOI: 10.1038/s41588-024-01854-z).
## Training procedure
### Training hyperparameters
The following hyperparameters were used during training:
- learning_rate: 5e-05
- train_batch_size: 32
- eval_batch_size: 32
- seed: 42
- optimizer: Adam with betas=(0.9,0.999) and epsilon=1e-08
- lr_scheduler_type: linear
- num_epochs: 7
### Training results
| Training Loss | Epoch | Step | Validation Loss | Accuracy Thresh |
|:-------------:|:-----:|:----:|:---------------:|:---------------:|
| No log | 1.0 | 106 | 0.1824 | 0.9475 |
| No log | 2.0 | 212 | 0.1339 | 0.9630 |
| No log | 3.0 | 318 | 0.1109 | 0.9689 |
| No log | 4.0 | 424 | 0.0988 | 0.9741 |
| 0.1439 | 5.0 | 530 | 0.0943 | 0.9743 |
| 0.1439 | 6.0 | 636 | 0.0891 | 0.9763 |
| 0.1439 | 7.0 | 742 | 0.0899 | 0.9760 |
### Framework versions
- Transformers 4.26.0
- Pytorch 1.12.1+cu102
- Datasets 2.9.0
- Tokenizers 0.13.2 |