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| import re | |
| import gradio as gr | |
| import pandas as pd | |
| import torch | |
| from model import MimicTransformer | |
| from utils import load_rule, get_attribution, get_diseases, get_drg_link, get_icd_annotations, visualize_attn | |
| from transformers import AutoTokenizer, AutoModel, set_seed, pipeline | |
| model_path = 'checkpoint_0_9113.bin' | |
| related_tensor = torch.load('discharge_embeddings.pt') | |
| all_summaries = pd.read_csv('all_summaries.csv')['SUMMARIES'].to_list() | |
| similarity_tokenizer = AutoTokenizer.from_pretrained('kamalkraj/BioSimCSE-BioLinkBERT-BASE') | |
| similarity_model = AutoModel.from_pretrained('kamalkraj/BioSimCSE-BioLinkBERT-BASE') | |
| similarity_model.eval() | |
| def read_model(model, path): | |
| model.load_state_dict(torch.load(path, map_location=torch.device('cpu')), strict=False) | |
| return model | |
| mimic = MimicTransformer(cutoff=512) | |
| mimic = read_model(model=mimic, path=model_path) | |
| tokenizer = mimic.tokenizer | |
| mimic.eval() | |
| # disease ner model | |
| pipe = pipeline("token-classification", model="alvaroalon2/biobert_diseases_ner") | |
| # default DRG summary examples | |
| ex1 = """HEAD CT: Head CT showed no intracranial hemorrhage or mass effect, but old infarction consistent with past medical history.""" | |
| ex2 = """Radiologic studies also included a chest CT, which confirmed cavitary lesions in the left lung apex consistent with infectious tuberculosis. This also moderate-sized left pleural effusion.""" | |
| ex3 = """We have discharged Mrs Smith on regular oral Furosemide (40mg OD) and we have requested an outpatient ultrasound of her renal tract which will be performed in the next few weeks. We will review Mrs Smith in the Cardiology Outpatient Clinic in 6 weeks time.""" | |
| ex4 = """Blood tests revealed a raised BNP. An ECG showed evidence of left-ventricular hypertrophy and echocardiography revealed grossly impaired ventricular function (ejection fraction 35%). A chest X-ray demonstrated bilateral pleural effusions, with evidence of upper lobe diversion.""" | |
| ex5 = """Mrs Smith presented to A&E with worsening shortness of breath and ankle swelling. On arrival, she was tachypnoeic and hypoxic (oxygen saturation 82% on air). Clinical examination revealed reduced breath sounds and dullness to percussion in both lung bases. There was also a significant degree of lower limb oedema extending up to the mid-thigh bilaterally.""" | |
| examples = [ex1, ex2, ex3, ex4, ex5] | |
| related_summaries = [[ex1]] | |
| related_chosen = [] | |
| related_attn = [] | |
| related_clr_bts = [] | |
| correct_drg_text_list = [] | |
| correct_salient_words_list = [] | |
| rule_df, drg2idx, i2d, d2mdc, d2w = load_rule('MSDRG_RULE13.csv') | |
| def mean_pooling(model_output, attention_mask): | |
| token_embeddings = model_output[0] #First element of model_output contains all token embeddings | |
| input_mask_expanded = attention_mask.unsqueeze(-1).expand(token_embeddings.size()).float() | |
| return torch.sum(token_embeddings * input_mask_expanded, 1) / torch.clamp(input_mask_expanded.sum(1), min=1e-9) | |
| def get_model_results(text): | |
| inputs = tokenizer(text, return_tensors='pt', padding='max_length', max_length=512, truncation=True) | |
| outputs = mimic(input_ids=inputs.input_ids, attention_mask=inputs.attention_mask, drg_labels=None) | |
| attribution, reconstructed_text = get_attribution(text=text, tokenizer=tokenizer, model_outputs=outputs, inputs=inputs, k=10) | |
| logits = outputs[0][0] | |
| out = logits.detach().cpu()[0] | |
| drg_code = i2d[out.argmax().item()] | |
| print(out.topk(5)) | |
| prob = torch.nn.functional.softmax(out).max() | |
| return { | |
| 'class': drg_code, | |
| 'prob': prob, | |
| 'attn': attribution, | |
| 'tokens': reconstructed_text, | |
| 'logits': logits | |
| } | |
| def find_related_summaries(text): | |
| inputs = similarity_tokenizer( | |
| text, padding='max_length', truncation=True, return_tensors='pt', max_length=512 | |
| ) | |
| outputs = similarity_model(**inputs) | |
| embedding = mean_pooling(outputs, attention_mask=inputs.attention_mask) | |
| embedding = torch.nn.functional.normalize(embedding) | |
| scores = torch.mm(related_tensor, embedding.transpose(1,0)) | |
| scores_indices = scores.topk(k=50, dim=0) | |
| indices, scores = scores_indices[-1], torch.round(100 * scores_indices[0], decimals=2) | |
| summary_score_list = [] | |
| score_set = set() | |
| for summary_idx, score in zip(indices, scores): | |
| score = score.item() | |
| if len(summary_score_list) == 5: | |
| break | |
| corresp_summary = all_summaries[summary_idx] | |
| if score in score_set: | |
| continue | |
| summary_score_list.append( | |
| [round(score,2), corresp_summary]) | |
| score_set.add(score) | |
| return summary_score_list | |
| def run(text, related_discharges=False): | |
| # initial drg results | |
| model_results = get_model_results(text=text) | |
| drg_code = model_results['class'] | |
| # find diseases | |
| diseases = get_diseases(text=text, pipe=pipe) | |
| model_results['diseases'] = diseases | |
| drg_link = get_drg_link(drg_code=drg_code) | |
| icd_results = get_icd_annotations(text=text) | |
| row = rule_df[rule_df['DRG_CODE'] == drg_code] | |
| drg_description = row['DESCRIPTION'].values[0] | |
| model_results['class_dsc'] = drg_description | |
| model_results['drg_link'] = drg_link | |
| model_results['icd_results'] = icd_results | |
| global related_summaries | |
| # related_summaries = generate_similar_summeries() | |
| related_summaries = find_related_summaries(text=text) | |
| if related_discharges: | |
| return visualize_attn(model_results=model_results) | |
| return ( | |
| visualize_attn(model_results=model_results), | |
| # gr.Dataset.update(samples=related_summaries, visible=True, label='Related Discharge Summaries'), | |
| gr.DataFrame.update(value=related_summaries, visible=True), | |
| gr.ClearButton.update(visible=True), | |
| gr.TextArea.update(visible=True), | |
| gr.Button.update(visible=True), | |
| gr.Button.update(visible=True), | |
| gr.TextArea.update(visible=True), | |
| gr.TextArea.update(visible=True) | |
| ) | |
| def run_related(): | |
| global related_chosen | |
| attn_list = [] | |
| clr_bts = [] | |
| correct_drg_list = [] | |
| correct_salient_list = [] | |
| for related in related_chosen: | |
| text = related[0] | |
| attn_html = run(text=text, related_discharges=True) | |
| attn_list.append(gr.HTML.update(value=attn_html)) | |
| clr_bts.append(gr.ClearButton.update(visible=True)) | |
| correct_drg_list.append(gr.Textbox.update(visible=True)) | |
| correct_salient_list.append(gr.Textbox.update(visible=True)) | |
| if len(attn_list) != 3: | |
| # find difference | |
| diff = 3 - len(attn_list) | |
| for i in range(diff): | |
| attn_list.append(gr.HTML.update(value='')) | |
| clr_bts.append(gr.ClearButton.update(visible=False)) | |
| correct_drg_list.append(gr.Textbox.update(visible=False)) | |
| correct_salient_list.append(gr.Textbox.update(visible=False)) | |
| return attn_list + clr_bts + correct_drg_list + correct_salient_list | |
| def load_example(example_id): | |
| global related_summaries | |
| global related_chosen | |
| sample = related_summaries[example_id][0] | |
| cleaned_sample = sample.split('% Similarity Rate for the following Discharge Summary:\n\n')[1:] | |
| related_chosen.append(cleaned_sample) | |
| return prettify_text(related_chosen) | |
| # return related_chosen | |
| def load_df_example(df, event: gr.SelectData): | |
| global related_chosen | |
| discharge_summary = event.value | |
| related_chosen.append([discharge_summary]) | |
| return prettify_text(related_chosen) | |
| def save_results(text): | |
| return gr.Textbox.update(value='Thank you for your input!') | |
| def prettify_text(nested_list): | |
| string = '' | |
| for li in nested_list: | |
| striped = re.sub(' +', ' ', li[0]).strip() | |
| delimiters = 99 * '=' | |
| string += f'{striped}\n{delimiters}\n' | |
| return string.strip() | |
| def remove_most_recent(): | |
| global related_chosen | |
| related_chosen = related_chosen[:-1] | |
| if len(related_chosen) == 0: | |
| return '' | |
| return prettify_text(related_chosen) | |
| def clr_btn(): | |
| return gr.ClearButton.update(visible=False), gr.Textbox.update(visible=False), gr.Textbox.update(visible=False) | |
| def main(): | |
| with gr.Blocks() as demo: | |
| gr.Markdown(""" | |
| # DRGCoder | |
| This interface outlines DRGCoder, an explainable clinical coding for the early prediction of diagnostic-related groups (DRGs). Please note all summaries will be truncated to 512 words if longer. | |
| """) | |
| with gr.Row() as row: | |
| input = gr.Textbox( | |
| label="Input Discharge Summary Here", placeholder='sample discharge summary', | |
| text_align='left', interactive=True | |
| ) | |
| with gr.Row() as row: | |
| gr.Examples(examples, [input]) | |
| with gr.Row() as row: | |
| btn = gr.Button(value="Submit") | |
| with gr.Row() as row: | |
| attn_viz = gr.HTML() | |
| with gr.Row() as row: | |
| with gr.Column() as col: | |
| correct_drg_text = gr.Textbox(visible=False, label="Input Correct DRG", interactive=True) | |
| correct_drg_text.submit(save_results, inputs=correct_drg_text, outputs=correct_drg_text) | |
| with gr.Column() as col: | |
| salient_words_box = gr.Textbox(visible=False, label="Input Salient Words (comma separated)", interactive=True) | |
| salient_words_box.submit(save_results, inputs=salient_words_box, outputs=salient_words_box) | |
| attn_clr_btn = gr.ClearButton(value='Remove DRG Results', visible=False, components=[attn_viz]) | |
| attn_clr_btn.click(clr_btn, outputs=[attn_clr_btn, correct_drg_text, salient_words_box]) | |
| # related row 1 | |
| with gr.Row() as row: | |
| attn_1 = gr.HTML() | |
| related_attn.append(attn_1) | |
| with gr.Row() as row: | |
| with gr.Column() as col: | |
| correct_drg_text_1 = gr.Textbox(visible=False, label="Input Correct DRG", interactive=True) | |
| correct_drg_text_1.submit(save_results, inputs=correct_drg_text_1, outputs=correct_drg_text_1) | |
| correct_drg_text_list.append(correct_drg_text_1) | |
| with gr.Column() as col: | |
| salient_words_box_1 = gr.Textbox(visible=False, label="Input Salient Words (comma separated)", interactive=True) | |
| salient_words_box_1.submit(save_results, inputs=salient_words_box_1, outputs=salient_words_box_1) | |
| correct_salient_words_list.append(salient_words_box_1) | |
| attn_clr_1 = gr.ClearButton(value='Remove DRG Results', visible=False, components=[attn_1]) | |
| related_clr_bts.append(attn_clr_1) | |
| attn_clr_1.click(clr_btn, outputs=[attn_clr_1, correct_drg_text_1, salient_words_box_1]) | |
| # related row 2 | |
| with gr.Row() as row: | |
| attn_2 = gr.HTML() | |
| related_attn.append(attn_2) | |
| with gr.Row() as row: | |
| with gr.Column() as col: | |
| correct_drg_text_2 = gr.Textbox(visible=False, label="Input Correct DRG", interactive=True) | |
| correct_drg_text_2.submit(save_results, inputs=correct_drg_text_2, outputs=correct_drg_text_2) | |
| correct_drg_text_list.append(correct_drg_text_2) | |
| with gr.Column() as col: | |
| salient_words_box_2 = gr.Textbox(visible=False, label="Input Salient Words (comma separated)", interactive=True) | |
| salient_words_box_2.submit(save_results, inputs=salient_words_box_2, outputs=salient_words_box_2) | |
| correct_salient_words_list.append(salient_words_box_2) | |
| attn_clr_2 = gr.ClearButton(value='Remove DRG Results', visible=False, components=[attn_2]) | |
| related_clr_bts.append(attn_clr_2) | |
| attn_clr_2.click(clr_btn, outputs=[attn_clr_2, correct_drg_text_2, salient_words_box_2]) | |
| # related row 3 | |
| with gr.Row() as row: | |
| attn_3 = gr.HTML() | |
| related_attn.append(attn_3) | |
| with gr.Row() as row: | |
| with gr.Column() as col: | |
| correct_drg_text_3 = gr.Textbox(visible=False, label="Input Correct DRG", interactive=True) | |
| correct_drg_text_3.submit(save_results, inputs=correct_drg_text_3, outputs=correct_drg_text_3) | |
| correct_drg_text_list.append(correct_drg_text_3) | |
| with gr.Column() as col: | |
| salient_words_box_3 = gr.Textbox(visible=False, label="Input Salient Words (comma separated)", interactive=True) | |
| salient_words_box_3.submit(save_results, inputs=salient_words_box_3, outputs=salient_words_box_3) | |
| correct_salient_words_list.append(salient_words_box_3) | |
| attn_clr_3 = gr.ClearButton(value='Remove DRG Results', visible=False, components=[attn_3]) | |
| related_clr_bts.append(attn_clr_3) | |
| attn_clr_3.click(clr_btn, outputs=[attn_clr_3, correct_drg_text_3, salient_words_box_3]) | |
| # input to related summaries | |
| with gr.Row() as row: | |
| input_related = gr.TextArea(label="Input up to 3 Related Discharge Summaries Here", visible=False, text_align='left', min_width=300) | |
| with gr.Row() as row: | |
| rmv_related_btn = gr.Button(value='Remove Related Summary', visible=False) | |
| sbm_btn = gr.Button(value="Submit Related Summaries", components=[input_related], visible=False) | |
| with gr.Row() as row: | |
| related = gr.DataFrame( | |
| value=None, headers=['Similarity Score', 'Related Discharge Summary'], max_rows=5, | |
| datatype=['number', 'str'], col_count=(2, 'fixed'), visible=False | |
| ) | |
| # initial run | |
| btn.click(run, inputs=[input], outputs=[ | |
| attn_viz, related, attn_clr_btn, input_related, | |
| sbm_btn, rmv_related_btn, correct_drg_text, salient_words_box | |
| ]) | |
| # find related summaries | |
| # related.click(load_example, inputs=[related], outputs=[input_related]) | |
| related.select(load_df_example, inputs=[related], outputs=[input_related]) | |
| # remove related summaries | |
| rmv_related_btn.click(remove_most_recent, outputs=[input_related]) | |
| # perform attribution on related summaries | |
| sbm_btn.click(run_related, outputs=related_attn + related_clr_bts + correct_drg_text_list + correct_salient_words_list) | |
| demo.launch() | |
| if __name__ == "__main__": | |
| main() |