app.py

from pathlib import Path
import numpy as np
import gradio as gr
import requests
from typing import List

# Define the COLUMN_MIN_MAX as provided
COLUMN_MIN_MAX = {
    "Age": (18, 100),
    "Blood_Glucose_Level": (0, 300),
    "Blood_Pressure_Systolic": (80, 200),
    "Blood_Pressure_Diastolic": (40, 120),
    "BMI": (10, 50),
    "Condition_Severity": (1, 10),
    "Gender": (0, 2),
    "Ethnicity": (0, 5),
    "Geographic_Location": (0, 6),
    "Smoking_Status": (0, 2),
    "Diagnoses_ICD10": (0, 5),
    "Medications": (0, 7),
    "Allergies": (0, 5),
    "Previous_Treatments": (0, 5),
    "Alcohol_Consumption": (0, 3),
    "Exercise_Habits": (0, 4),
    "Diet": (0, 5),
    "Functional_Status": (0, 2),
    "Previous_Trial_Participation": (0, 1),
}

# Define possible categories for fields without predefined categories
additional_categories = {
    "Gender": ["Male", "Female", "Other"],
    "Ethnicity": ["White", "Black or African American", "Asian", "American Indian or Alaska Native", "Native Hawaiian or Other Pacific Islander", "Other"],
    "Geographic_Location": ["North America", "South America", "Europe", "Asia", "Africa", "Australia", "Antarctica"],
    "Smoking_Status": ["Never", "Former", "Current"],
    "Diagnoses_ICD10": ["Actinic keratosis", "Melanoma", "Dermatofibroma", "Vascular lesion","None"],
    "Medications": ["Metformin", "Lisinopril", "Atorvastatin", "Amlodipine", "Omeprazole", "Simvastatin", "Levothyroxine", "None"],
    "Allergies": ["Penicillin", "Peanuts", "Shellfish", "Latex", "Bee stings", "None"],
    "Previous_Treatments": ["Chemotherapy", "Radiation Therapy", "Surgery", "Physical Therapy", "Immunotherapy", "None"],
    "Alcohol_Consumption": ["None", "Occasionally", "Regularly", "Heavy"],
    "Exercise_Habits": ["Sedentary", "Light", "Moderate", "Active", "Very Active"],
    "Diet": ["Omnivore", "Vegetarian", "Vegan", "Pescatarian", "Keto", "Mediterranean"],
    "Functional_Status": ["Independent", "Assisted", "Dependent"],
    "Previous_Trial_Participation": ["Yes", "No"]
}

# Define the input components for the researcher form with constraints
min_age_input = gr.Number(label="Minimum Age", value=18, minimum=COLUMN_MIN_MAX["Age"][0], maximum=COLUMN_MIN_MAX["Age"][1])
max_age_input = gr.Number(label="Maximum Age", value=100, minimum=COLUMN_MIN_MAX["Age"][0], maximum=COLUMN_MIN_MAX["Age"][1])

gender_input = gr.CheckboxGroup(choices=additional_categories["Gender"], label="Gender", value=["Male"])
ethnicity_input = gr.CheckboxGroup(choices=additional_categories["Ethnicity"], label="Ethnicity", value=["White"])
geographic_location_input = gr.CheckboxGroup(choices=additional_categories["Geographic_Location"], label="Geographic Location", value=["North America"])
diagnoses_icd10_input = gr.CheckboxGroup(choices=additional_categories["Diagnoses_ICD10"], label="Skin Diagnosis", value=["Actinic keratosis"])
medications_input = gr.CheckboxGroup(choices=additional_categories["Medications"], label="Medications", value=["Metformin"])
allergies_input = gr.CheckboxGroup(choices=additional_categories["Allergies"], label="Allergies", value=["Peanuts"])
previous_treatments_input = gr.CheckboxGroup(choices=additional_categories["Previous_Treatments"], label="Previous Treatments", value=["None"])

min_blood_glucose_level_input = gr.Number(label="Minimum Blood Glucose Level", value=0, minimum=COLUMN_MIN_MAX["Blood_Glucose_Level"][0], maximum=COLUMN_MIN_MAX["Blood_Glucose_Level"][1])
max_blood_glucose_level_input = gr.Number(label="Maximum Blood Glucose Level", value=3, minimum=COLUMN_MIN_MAX["Blood_Glucose_Level"][0], maximum=COLUMN_MIN_MAX["Blood_Glucose_Level"][1])
blood_glucose_level_input = gr.Number(label="Blood Glucose Level", value=100, minimum=COLUMN_MIN_MAX["Blood_Glucose_Level"][0], maximum=COLUMN_MIN_MAX["Blood_Glucose_Level"][1])

min_blood_pressure_systolic_input = gr.Number(label="Minimum Blood Pressure (Systolic)", value=0, minimum=COLUMN_MIN_MAX["Blood_Pressure_Systolic"][0], maximum=COLUMN_MIN_MAX["Blood_Pressure_Systolic"][1])
max_blood_pressure_systolic_input = gr.Number(label="Maximum Blood Pressure (Systolic)", value=3, minimum=COLUMN_MIN_MAX["Blood_Pressure_Systolic"][0], maximum=COLUMN_MIN_MAX["Blood_Pressure_Systolic"][1])
blood_pressure_systolic_input = gr.Number(label="Blood Pressure (Systolic)", value=120, minimum=COLUMN_MIN_MAX["Blood_Pressure_Systolic"][0], maximum=COLUMN_MIN_MAX["Blood_Pressure_Systolic"][1])

min_blood_pressure_diastolic_input = gr.Number(label="Minimum Blood Pressure (Diastolic)", value=0, minimum=COLUMN_MIN_MAX["Blood_Pressure_Diastolic"][0], maximum=COLUMN_MIN_MAX["Blood_Pressure_Diastolic"][1])
max_blood_pressure_diastolic_input = gr.Number(label="Maximum Blood Pressure (Diastolic)", value=3, minimum=COLUMN_MIN_MAX["Blood_Pressure_Diastolic"][0], maximum=COLUMN_MIN_MAX["Blood_Pressure_Diastolic"][1])
blood_pressure_diastolic_input = gr.Number(label="Blood Pressure (Diastolic)", value=80, minimum=COLUMN_MIN_MAX["Blood_Pressure_Diastolic"][0], maximum=COLUMN_MIN_MAX["Blood_Pressure_Diastolic"][1])

min_bmi_input = gr.Number(label="Minimum BMI", value=0, minimum=COLUMN_MIN_MAX["BMI"][0], maximum=COLUMN_MIN_MAX["BMI"][1])
max_bmi_input = gr.Number(label="Maximum BMI", value=3, minimum=COLUMN_MIN_MAX["BMI"][0], maximum=COLUMN_MIN_MAX["BMI"][1])
bmi_input = gr.Number(label="BMI", value=20, minimum=COLUMN_MIN_MAX["BMI"][0], maximum=COLUMN_MIN_MAX["BMI"][1])

min_condition_severity_input = gr.Number(label="Condition Severity", value=5, minimum=COLUMN_MIN_MAX["Condition_Severity"][0], maximum=COLUMN_MIN_MAX["Condition_Severity"][1])
max_condition_severity_input = gr.Number(label="Condition Severity", value=5, minimum=COLUMN_MIN_MAX["Condition_Severity"][0], maximum=COLUMN_MIN_MAX["Condition_Severity"][1])
condition_severity_input = gr.Number(label="Condition Severity", value=5, minimum=0, maximum=10)

smoking_status_input = gr.CheckboxGroup(choices=additional_categories["Smoking_Status"], label="Smoking Status", value=["Never"])
alcohol_consumption_input = gr.CheckboxGroup(choices=additional_categories["Alcohol_Consumption"], label="Alcohol Consumption", value=["None"])
exercise_habits_input = gr.CheckboxGroup(choices=additional_categories["Exercise_Habits"], label="Exercise Habits", value=["Sedentary"])
diet_input = gr.CheckboxGroup(choices=additional_categories["Diet"], label="Diet", value=["Omnivore"])

functional_status_input = gr.CheckboxGroup(choices=additional_categories["Functional_Status"], label="Functional Status", value=["Independent"])
previous_trial_participation_input = gr.CheckboxGroup(choices=additional_categories["Previous_Trial_Participation"], label="Previous Trial Participation", value=["No"])
# Define the server's URL
SERVER_URL = "https://affordable-prot-bind-clarke.trycloudflare.com/requirements/create"  # Ensure this is the correct endpoint

def encode_categorical_data(data: List[str], category_name: str) -> List[int]:
    """Encodes a list of categorical values into their corresponding indices based on additional_categories."""
    sub_cats = additional_categories.get(category_name, [])
    encoded_data = []
    for value in data:
        if value in sub_cats:
            encoded_index = sub_cats.index(value)
            # Validate that the encoded index is within the specified range
            min_val, max_val = COLUMN_MIN_MAX.get(category_name, (0, len(sub_cats)-1))
            if min_val <= encoded_index <= max_val:
                encoded_data.append(encoded_index)
            else:
                print(f"Encoded value for {category_name}='{value}' is out of range. Setting to 0.")
                encoded_data.append(0)
        else:
            print(f"Value '{value}' not recognized in category '{category_name}'. Setting to 0.")
            encoded_data.append(0)
    return encoded_data

def process_researcher_data(
    min_age, max_age, gender, ethnicity, geographic_location, diagnoses_icd10, medications, allergies, previous_treatments,
    min_blood_glucose_level, max_blood_glucose_level, min_blood_pressure_systolic, max_blood_pressure_systolic,
    min_blood_pressure_diastolic, max_blood_pressure_diastolic, min_bmi, max_bmi, smoking_status, alcohol_consumption,
    exercise_habits, diet, min_condition_severity, max_condition_severity, functional_status, previous_trial_participation
):
    # Encode categorical data
    encoded_gender = encode_categorical_data(gender, "Gender")
    encoded_ethnicity = encode_categorical_data(ethnicity, "Ethnicity")
    encoded_geographic_location = encode_categorical_data(geographic_location, "Geographic_Location")
    encoded_diagnoses_icd10 = encode_categorical_data(diagnoses_icd10, "Diagnoses_ICD10")
    encoded_medications = encode_categorical_data(medications, "Medications")
    encoded_allergies = encode_categorical_data(allergies, "Allergies")
    encoded_previous_treatments = encode_categorical_data(previous_treatments, "Previous_Treatments")
    encoded_smoking_status = encode_categorical_data(smoking_status, "Smoking_Status")
    encoded_alcohol_consumption = encode_categorical_data(alcohol_consumption, "Alcohol_Consumption")
    encoded_exercise_habits = encode_categorical_data(exercise_habits, "Exercise_Habits")
    encoded_diet = encode_categorical_data(diet, "Diet")
    encoded_functional_status = encode_categorical_data(functional_status, "Functional_Status")
    encoded_previous_trial_participation = encode_categorical_data(previous_trial_participation, "Previous_Trial_Participation")

    # Create a list of requirements
    requirements = []

    # Add numerical requirements
    numerical_fields = [
        ("Age", min_age, "greater_than"),
        ("Age", max_age, "less_than"),
        ("Blood_Glucose_Level", min_blood_glucose_level, "greater_than"),
        ("Blood_Glucose_Level", max_blood_glucose_level, "less_than"),
        ("Blood_Pressure_Systolic", min_blood_pressure_systolic, "greater_than"),
        ("Blood_Pressure_Systolic", max_blood_pressure_systolic, "less_than"),
        ("Blood_Pressure_Diastolic", min_blood_pressure_diastolic, "greater_than"),
        ("Blood_Pressure_Diastolic", max_blood_pressure_diastolic, "less_than"),
        ("BMI", min_bmi, "greater_than"),
        ("BMI", max_bmi, "less_than"),
        ("Condition_Severity", min_condition_severity, "greater_than"),
        ("Condition_Severity", max_condition_severity, "less_than"),
    ]

    for field, value, comparison in numerical_fields:
        if value is not None:
            # Ensure the value is within the specified range
            min_val, max_val = COLUMN_MIN_MAX.get(field, (None, None))
            if min_val is not None and max_val is not None:
                if not (min_val <= value <= max_val):
                    print(f"Value for {field}={value} is out of range ({min_val}, {max_val}). Adjusting to fit within range.")
                    value = max(min(value, max_val), min_val)
            requirements.append({
                "column_name": field,
                "value": value,
                "comparison_type": comparison
            })

    # Add categorical requirements
    categorical_fields = [
        ("Gender", encoded_gender, "equal"),
        ("Ethnicity", encoded_ethnicity, "equal"),
        ("Geographic_Location", encoded_geographic_location, "equal"),
        ("Diagnoses_ICD10", encoded_diagnoses_icd10, "equal"),
        ("Medications", encoded_medications, "equal"),
        ("Allergies", encoded_allergies, "equal"),
        ("Previous_Treatments", encoded_previous_treatments, "equal"),
        ("Smoking_Status", encoded_smoking_status, "equal"),
        ("Alcohol_Consumption", encoded_alcohol_consumption, "equal"),
        ("Exercise_Habits", encoded_exercise_habits, "equal"),
        ("Diet", encoded_diet, "equal"),
        ("Functional_Status", encoded_functional_status, "equal"),
        ("Previous_Trial_Participation", encoded_previous_trial_participation, "equal"),
    ]

    for field, encoded_values, comparison in categorical_fields:
        min_val, max_val = COLUMN_MIN_MAX.get(field, (0, len(additional_categories[field])-1))
        for encoded in encoded_values:
            if min_val <= encoded <= max_val:
                requirements.append({
                    "column_name": field,
                    "value": encoded,
                    "comparison_type": comparison
                })
            else:
                print(f"Encoded value {encoded} for {field} is out of range ({min_val}, {max_val}). Skipping.")

    # Encode and add non-categorical fields like medications, allergies, previous treatments
    # Already handled above in categorical_fields

    # Construct the payload as a regular dictionary
    payload = {
        "model_name": "second_model",
        "requirements": requirements
    }

    print("Payload to send:", payload)  # For debugging

    # Make the request to the server
    try:
        res = requests.post(SERVER_URL, json=payload)
        res.raise_for_status()  # Raise an error for bad status codes
    except requests.exceptions.HTTPError as http_err:
        print(f"HTTP error occurred: {http_err}")  # For debugging
        return f"HTTP error occurred: {http_err}"
    except Exception as err:
        print(f"Other error occurred: {err}")  # For debugging
        return f"Other error occurred: {err}"

    # Get the response from the server
    try:
        response = res.json()
        print("Server response:", response)
    except ValueError:
        print("Response is not in JSON format.")
        return "Response is not in JSON format."

    return response.get("message", "No message received from server")

# Create the Gradio interface for researchers
researcher_demo = gr.Interface(
    fn=process_researcher_data, 
    inputs=[
        min_age_input, max_age_input, gender_input, ethnicity_input, geographic_location_input, diagnoses_icd10_input, 
        medications_input, allergies_input, previous_treatments_input, min_blood_glucose_level_input, 
        max_blood_glucose_level_input, min_blood_pressure_systolic_input, max_blood_pressure_systolic_input, 
        min_blood_pressure_diastolic_input, max_blood_pressure_diastolic_input, min_bmi_input, max_bmi_input, 
        smoking_status_input, alcohol_consumption_input, exercise_habits_input, diet_input, 
        min_condition_severity_input, max_condition_severity_input, functional_status_input, previous_trial_participation_input
    ], 
    outputs="text",
    title="Clinical Researcher Criteria Form",
    description="Please enter the criteria for the type of patients you are looking for."
)

# Launch the researcher interface with a public link
if __name__ == "__main__":
    researcher_demo.launch(share=False)