SaProtHub/DMS_RASH_HUMAN

Base model: westlake-repl/SaProt_35M_AF2

Model Card for Model ID

This model is trained on a sigle site deep mutation scanning dataset and can be used to predict fitness score of mutant amino acid sequence of protein RASH_HUMAN (GTPase HRas).

Protein Function

This protein involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Task type

protein level regression

Dataset description

The dataset is from Deep generative models of genetic variation capture the effects of mutations. And can also be found on SaprotHub dataset.

Label means fitness score of each mutant amino acid sequence, ranging from minus infinity to positive infinity where 0 is value of wildtype, larger means higher fitness.

Model input type

Amino acid sequence

Performance

0.64 Spearman's ρ

LoRA config

lora_dropout: 0.0

lora_alpha: 16

target_modules: ["query", "key", "value", "intermediate.dense", "output.dense"]

modules_to_save: ["classifier"]

Training config

class: AdamW

betas: (0.9, 0.98)

weight_decay: 0.01

learning rate: 1e-4

epoch: 50

batch size: 256

precision: 16-mixed