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ESGBERT 25

Our Coaching Learning Path highlights a variety of options to help leaders learn, practice, and build their coaching skills.

Rewarding Innovation Innovation is a core element of our culture and success.

VP, Regulatory Affairs The mentorship program has opened a space for me to get candid feedback and thoughtful advice on how to navigate the corporate landscape, improve my professional interactions, and grow visibility inside the company.

EHS Management System We continue to work under a management system framework to measure performance and continually seek improvement.

Precautionary ApproachThe precautionary approach is embedded in our risk assessments, our environmental aspects/impacts, our EHS Policy, Product Stewardship, and the engagement of our people.

We have established a series of grassroots safety culture teams that drive continuous improvement projects.

We embrace our mission through the establishment, implementation, and maintenance of an integrated EHS management system.

to our EHS policy Compact Principle 15 state in order to protect the environment, the precautionary approach shall be applied.

Our Emergency Action teams—which include our Evacuation Sweep team, first aid volunteers, and Chemical Incidental Spill Response team—work together to create awareness and lead regular preparedness drills and activities.

In our CSR program and across our business, we are committed to conducting ourselves with honesty, integrity, and respect for all.

A: We put a strong governance foundation in action through our Code of Conduct and compliance programs.

We anchor to that Code in how we run the company, and require annual certification.

That culture of compliance and ethics starts at the Board level and is incorporated into every level of our business.

The Board provides oversight on our CSR program, including the key tenets of sustainability and our response to climate change.

The EAB assists us on privacy, ethics, and emerging issues in the genomic space, as we continue to lead in all matters that our technology might touch.

A: The Illumina Corporate Foundation is one element of our holistic giving approach that impacts our CSR focus areas.

Our Objectives The tenets of strong governance are foundational to doing business responsibly.

We put this in action through our Code of Conduct and compliance programs.

For us, doing the right thing is more than just compliance, it is about having a deep sense of integrity and honoring the trust given to us by employees, patients, customers, shareholders, and our communities.

Governance With Integrity Good corporate governance involves balancing the interests of all our stakeholders, including our employees, customers, patients, suppliers, community, government, and shareholders.

By exercising strong corporate governance and ethical leadership, we aim to inspire confidence in our company’s future, and create a safe and supportive work environment for our employees.

Board of Directors Our culture of compliance and ethics starts at Board level, the highest level of our leadership, and is integrated into every level of our business.

The Board has adopted Corporate Governance Guidelines founded on a commitment to building shareholder value, with an emphasis on responsible governance.

These guidelines, together with the Code of Conduct and Board Committee Charters, provide the framework for corporate governance at Illumina. Board Diversity As specified in the Corporate Governance Guidelines, our company seeks to achieve a Board mix that represents a diversity of backgrounds and experience.

Furthermore, our governance guidelines require that independent directors constitute at least a majority of the Board.

Our Board has four Board Committees: • Audit Committee • Compensation Committee • Nominating/Corporate Governance Committee • Science and Technology Committee Ethics Advisory Board Established in (EAB) advises and provides recommendations on ethical issues, policies, and regulations relevant to the genomics industry, including those related to Illumina’s existing, emerging, and prospective products, services, and processes from a research and clinical perspective.

Compliance Committee The Compliance Committee directs and oversees our compliance activities, including the administration of our Code of Conduct.

It is composed of senior executives, and chaired by our General Counsel, who is also the Chief Compliance Officer.

• Foster a culture of ethics and compliance • Advocate and promote global awareness of the company’s compliance program efforts The Compliance Committee has adopted a program framework based upon the seven fundamental elements of an effective compliance program established by the Office of Inspector General.

Reporting Hotline We are committed to fostering a culture in which employees feel comfortable raising compliance concerns without fear of retaliation.

To this end, we promote an open door policy that encourages our people to raise any concerns or questions with their manager, human resources, and/or the compliance reporting resources.

To help facilitate the reporting of good faith concerns, we have established a third-party compliance hotline and website that Illumina employees and others may use for reporting concerns.

The Compliance and Fraud Prevention reporting resources are available to both employees and third-party partners, at (800-461-9330), or electronically at Compliance and Fraud Prevention Reporting.

Callers may choose to self identify or remain anonymous (where permitted by law) when reporting.

We take pride in conducting our business with honesty and transparency, and in accordance with legal standards and ethical principles.

Culture of Compliance Our policies guide employees on how to apply a culture of compliance to their daily work.

Our Code of Conduct promotes honest and ethical conduct, compliance with applicable laws and regulations, and protection of our business interests.

Our Code lays out guidance on making ethical decisions while conducting business on behalf of Illumina.

Key topics include fraud prevention, bribery and corruption, anti-discrimination, anti-harassment, human rights, diversity and inclusion, employee safety, corporate social responsibility, marketing and sales claims, and government interaction.

and Training Our Compliance Committee directs and oversees compliance activities, including administration of our Code of Conduct.

We actively engage our employees in our ethical governance program to ensure they have a thorough understanding of what is expected of them.

We offer Code of Conduct training through our enterprise learning management system (LMS).

Anti-Corruption and Anti-Bribery We forbid bribery and corruption in the conduct of our business, and comply with anti-corruption laws wherever we operate.

We support businesses working against corruption in all its forms, including extortion and bribery, and expect all our partners to maintain the same standards.

Anti-Competitive Behavior We aim to compete and succeed in a fair and honest marketplace, and do not engage in unethical, unfair, or illegal communications with competitors.

We do not enter into formal or informal agreements with competitors to engage in any anti-competitive behavior, and strictly comply with all related laws.

We forbid anti-competitive behavior, antitrust, and monopoly practices.

The Illumina Policy for Interactions with Healthcare Professionals and Organizations guides how we conduct business with these groups, together with ensuring compliance with applicable laws, regulations, and standards of conduct.

Right to exercise freedom of association • Fair wages and working hours • Protection of privacy • Safe workplace • Elimination of child and forced labor • Equal opportunity Human Rights Impact Assessment In rights impact assessment to review additional opportunities.

We have highlighted a few of our key Human Rights Policy pledges: Elimination of Child Labor, Forced Labor, and Human Trafficking We condemn all forms of exploitation of children, will not recruit child labor, and support the elimination of exploitive child labor.

Safe Workplace Our Injury and Illness Prevention Program and Environment, Health and Safety (EHS) Management System Policy enable us to proactively manage risk and engage employees.

In addition, the Illumina State Sponsors of Terrorism (SST) Policy prohibits business in or with SST countries, as defined by the US Department of State, and the Illumina Sanctioned and Embargoed Countries Policy prohibits business in or with parties (country, entity, individual) that violate any applicable trade sanction regulations in the countries where we do business.

This policy is based on the foundation of compliance with economic sanctions, laws, and regulations administered by the United States Department of the Treasury, Office of Foreign Assets Control (OFAC), and all applicable trade sanction regulations in the countries where we do business.

The Internal Audit Department provides independent and objective feedback to the Board Audit Committee.

We continue to assess risks in our business, and endeavor to ensure that all employees adhere to our ethics and compliance protocols.

https://www.illumina.com/company/legal/privacy.html https://emea.illumina.com/content/dam/illumina-marketing/documents/company/privacy-principles_120219.pdf Cybersecurity Genomics data is powering positive progress around the world.

We consider it business-critical to work with suppliers who share our commitment to integrity, and who support an ethical and compliant culture.

The Illumina Supplier Code of Conduct is consistent with commitments we made both as a signatory of the United Nations Global Compact and as a member of the Dow Jones Sustainability World Index.

All new suppliers are required to acknowledge the Supplier Code of Conduct in order to complete the onboarding process.

Our updated Supplier Code of Conduct now includes guidance for suppliers to provide options that support environmentally preferable products (EPP) that meet performance requirements when submitting proposals to Illumina for commodities and services, wherever possible.

Our internal buying teams will prioritize purchasing EPPs when competing products have comparable function and value.

and the Illumina Human Rights Policy • Ensure a safe and healthy workplace • Demonstrate social and environmental responsibility • Conduct business in an ethical manner Supplier Diversity Program Illumina is committed to establishing collaborative partnerships with qualified small and diverse suppliers and recognizes the importance of ensuring our supply base reflects the diversity of the communities in which we live, work, and serve.

We split our suppliers into the following categories: direct, indirect, strategic, differentiating, core, transactional, finished medical device, custom spec, off the shelf, internal, external, and services.

https://www.illumina.com/content/dam/illumina-marketing/documents/company/illumina-supplier-diversity-program.pdf https://www.illumina.com/content/dam/illumina-marketing/documents/company/supplier-code-of-conduct.pdf https://www.illumina.com/content/dam/illumina-marketing/documents/company/supplier-code-of-conduct.pdf https://www.illumina.com/content/dam/illumina-marketing/documents/company/human-rights-policy.pdf Verification and Due Diligence We perform due diligence on new business partners to verify that they meet our standards.

Modern Slavery Illumina is committed to conducting its business lawfully and with integrity.

Furthermore, through our Conflict-Free Minerals Policy we expect all our suppliers to establish their own due diligence program to ensure supply chains are free of conflict minerals and to make their due diligence measures available to Illumina upon request.

The Illumina Channel Partner Code of Conduct requires that channel partners match Illumina’s commitment to business integrity, ethical conduct in the marketplace, adherence to all applicable laws, and the fundamental elements of human rights.

ESG AppendixIntegrity https://www.illumina.com/content/dam/illumina-marketing/documents/company/illumina-ca-transparency-supply-chain-modern-slavery.pdf https://www.illumina.com/content/dam/illumina-marketing/documents/company/illumina-ca-transparency-supply-chain-modern-slavery.pdf http://www.responsiblebusiness.org/code-of-conduct/ http://www.responsiblebusiness.org/code-of-conduct/ https://www.illumina.com/content/dam/illumina-marketing/documents/company/supply-chain-conflict-free-minerals.pdf https://www.illumina.com/content/dam/illumina-marketing/documents/company/investor-relations/code-of-conduct.pdf https://www.advamed.org/issues/code-ethics/code-ethics https://www.advamed.org/issues/code-ethics/code-ethics https://www.medtecheurope.org/resource-library/medtech-europe-code-of-ethical-business-practice https://www.medtecheurope.org/resource-library/medtech-europe-code-of-ethical-business-practice Supplier Quality Vision and Values The aim of the Illumina Supplier Quality Vision is to construct and foster a leading supplier base that ensures safe and quality products every time.

The supplier quality management life cycle incorporates the following phases: • Initial risk assessments • Qualification • Audits • Monitoring Working with our suppliers, we can focus on the customer experience, continual improvement, effectiveness of our quality management system, and compliance.

Product Quality Quality Policy Illumina is dedicated to being the leading provider of integrated solutions that advance the understanding of genetics and health.

We will achieve this through our focus on the customer experience, our commitment to continual improvement, maintaining the effectiveness of our quality management system, and complying with regulatory requirements.

Partnering With Policymakers to Improve Human Health We believe proactive, responsible engagement with public policy stakeholders translates to sharing accurate and reliable information about genomics and advocating for policies that ensure and promote broad access.

Illumina participates in the political and public policy process with governments and organizations around the world to engage and educate policymakers and key stakeholders on issues that impact our mission and business.

Pursuant to our Code of Conduct, we commit to deal with governments, government agencies, and public officials according to the highest ethical standards and in compliance with all applicable laws.

They may also provide expertise on policy and specific regional issues.

Disclosures & Transparency Illumina complies with all applicable laws and requirements in connection with its global political and public policy activities.

As part of this policy, we disclose memberships in trade associations for which we contributed over $as well as the total amount of such dues.

Section Code, such as payments to organizations designated as 501(c)(4) and 501(c)(6).

Oversight How we interact with policymakers must align with our core values, ethical responsibilities and legal obligations.

The Nominating/Corporate Governance Committee of Illumina’s Board of Directors oversees this policy and Illumina’s contribution practices.

The Committee maintains responsibility for ensuring all Illumina political activities promote ethical and transparent engagement, advance the Company’s mission, and comply with applicable laws and reporting requirements.

On an annual basis, Illumina will provide an update on the Company’s public policy priorities, political contributions, lobbying expenditures, and information about significant memberships.

It has been designed to address disclosures and material issues to provide a comprehensive and integrated view of our commitments, progress, and activities related to sustainability and corporate social responsibility.

This section contains key performance indicators for select economic, social, environmental, and governance metrics.

% Choose not to self disclose Notes: 1 % data for new hire by age represents the percentage of the total age group headcount for the reporting year.

Main outcomes of completed legal actions, including any decisions or judgments: The International Equipment Trading, Ltd. (IET) civil action noted in our Illumina expressly denying any liability or wrongdoing.

All data points that have been adjusted are called out with †. Governance Non-compliance with environmental laws and regulations Significant fines and non-monetary sanctions for non-compliance with environmental laws and/or regulations 0 0 # of FDA recalls/total units recalled 0 0 Number of substantiated complaints concerning breaches of customer privacy and losses of customer data 0 0 Anti-corruption 0 0 Anti-competitive1 2 0 Nature and total number of critical concerns communicated to highest governance body regarding CSR topics 0 0 Total employees covered by collective bargaining agreements 0 0 Incidents of discrimination and corrective actions taken During the past 11 years, neither the EEOC nor any court or administrative agency has issued a finding against Illumina in a claim involving discrimination.

Illumina is reporting to the SASB Standards for the first time in 2021 based on our 2020 reporting data.

We are committed to supporting improvements on the effectiveness and comparability of corporate disclosure on environmental, social, and governance (ESG) factors.

Task Force on Climate-related Financial Disclosures (TCFD) Index Illumina is committed to providing transparency on our climate change risk management.

We have used the TCFD recommendations to guide our reporting.

Focus on Illumina, TCFD Details Management role Describe management role in assessing and managing risks and opportunities.

Process to integrate climate risk in overall risk management Describe how processes for identifying, assessing, and managing climate-related risks are integrated into the organization’s overall risk management.

Governance The Board of Directors (Board) provides oversight to the CSR program covering environmental, social, and governance (ESG) topics, including climate-related issues.

The CSR functional group reports directly to the Chief Financial Officer (CFO), with responsibility for program recommendations, management, reporting, and oversight on efforts to incorporate sustainability into our business practices.

For financial planning, we include risk and opportunities evaluated through our standard budget planning.

Potential indirect cost associated with supply chain, future tax, or increased operating costs from extreme weather would connect with these internal workstreams.

Limited action on climate policy will be taken and a doubling down on fossil-based energy sources will result.

Under the well below economic recovery that fully embraces the low-carbon transition, with strong climate policy and regulatory action.

The implications for each scenario were discussed and participants identified risk and opportunity hot spots to help direct further integration of resilience planning and embed climate into our developing enterprise risk management program.