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The following is a medical question about drug interactions. Provide a detailed answer. | Question: how much iron should an anemic take per day | Answer: The amount of iron needed to treat patients with iron deficiency is higher than the amount found in most daily multivitamin supplements. The amount of iron prescribed by your doctor will be in milligrams (mg) of elemental iron. Most people with iron deficiency need 150-200 mg per day of elemental iron (2 to 5 mg of iron per kilogram of body weight per day). Ask your doctor how many milligrams of iron you should be taking per day. If you take vitamins, bring them to your doctor's visit to be sure.
For more information, visit: http://www.hematology.org/Patients/Anemia/Iron-Deficiency.aspx |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: what is in lidocaine | Answer: LIDOCAINE HYDROCHLORIDE ANHYDROUS 10 mg in 1 mL
INACTIVE INGREDIENTS
SODIUM CHLORIDE 7 mg in 1 mL
SODIUM HYDROXIDE
HYDROCHLORIC ACID
For more information, visit: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e0e479e6-4c94-44d0-8074-d0ee7b2bde22&audience=consumer |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: when taking plavix and xarelto blood thinners is it safe to take dilaudid for pain | Answer: Tell your doctor and pharmacist if you are taking anagrelide (Agrylin); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin, others), indomethacin (Indocin, Tivorbex), ketoprofen, and naproxen (Aleve, Anaprox, others); cilostazol (Pletal); clopidogrel (Plavix); dipyridamole (Persantine); eptifibatide (Integrilin); heparin; prasugrel (Effient); ticagrelor (Brilinta); ticlopidine; tirofiban (Aggrastat), and warfarin (Coumadin, Jantoven). If you experience any of the following symptoms, call your doctor immediately: back pain, muscle weakness, numbness or tingling (especially in your legs), loss of control of your bowels or bladder, or inability to move your legs.
For more information, visit: https://medlineplus.gov/druginfo/meds/a611049.html |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: is erythromycin ophthalmic ointment good for inflamed eyelids? | Answer: For the treatment of superficial ocular infections involving the conjunctiva and/or cornea caused by organisms susceptible to erythromycin.
For more information, visit: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a0353c10-48c9-4d2a-8047-56ea68ace956&audience=consumer |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: how should i dilute ceftriaxone injection? | Answer: Ceftriaxone has been shown to be compatible with Flagyl®*IV (metronidazole hydrochloride). The concentration should not exceed 5 to 7.5 mg/mL metronidazole hydrochloride with ceftriaxone 10 mg/mL as an admixture. The admixture is stable for 24 hours at room temperature only in 0.9% sodium chloride injection or 5% dextrose in water (D5W). No compatibility studies have been conducted with the Flagyl®*IV RTU® or using other diluents. Metronidazole at concentrations greater than 8 mg/mL will precipitate. Do not refrigerate the admixture as precipitation will occur.
Vancomycin and fluconazole are physically incompatible with ceftriaxone in admixtures. When either of these drugs is to be administered concomitantly with ceftriaxone by intermittent intravenous infusion, it is recommended that they be given sequentially, with thorough flushing of the intravenous lines (with one of the compatible fluids) between the administrations.
Do not use diluents containing calcium, such as Ringer’s solution or Hartmann’s solution, to reconstitute ceftriaxone for injection. Particulate formation can result.
Ceftriaxone solutions should not be physically mixed with or piggybacked into solutions containing other antimicrobial drugs or into diluent solutions other than those listed above, due to possible incompatibility (see WARNINGS).
For more information, visit: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f5d7ae2f-5485-42e2-af2b-bd7f06df85d7&audience=consumer |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: symptoms from taking multiple doses of lasix 40 mg per dayproblems with taking lasix 40mg twice daily ? | Answer: Furosemide is a strong diuretic ('water pill') and may cause dehydration and electrolyte imbalance. It is important that you take it exactly as told by your doctor. If you experience any of the following symptoms, call your doctor immediately: decreased urination; dry mouth; thirst; nausea; vomiting; weakness; drowsiness; confusion; muscle pain or cramps; or rapid or pounding heartbeats.
For more information, visit: https://medlineplus.gov/druginfo/meds/a682858.html |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: how long for allergic reaction after using nivolumab | Answer: n patients receiving OPDIVO as a single agent, immune-mediated pneumonitis occurred in 3.1% (61/1994) of patients. The median time to onset of immune-mediated pneumonitis was 3.5 months (range: 1 day to 22.3 months). Immune-mediated pneumonitis led to permanent discontinuation of OPDIVO in 1.1%, and withholding of OPDIVO in 1.3% of patients. Approximately 89% of patients with pneumonitis received high-dose corticosteroids (at least 40 mg prednisone equivalents per day) for a median duration of 26 days (range: 1 day to 6 months). Complete resolution of symptoms following corticosteroid taper occurred in 67% of patients. Approximately 8% of patients had recurrence of pneumonitis after re-initiation of OPDIVO.
For more information, visit: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f570b9c4-6846-4de2-abfa-4d0a4ae4e394&audience=consumer |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: where does fluorouracil come from | Answer: Fluorouracil is a nucleoside metabolic inhibitor that interferes with the synthesis of deoxyribonucleic acid (DNA) and to a lesser extent inhibits the formation of ribonucleic acid (RNA); these affect rapidly growing cells and may lead to cell death.
For more information, visit: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8eff167f-203a-4a81-b2fc-d8773bc3555e&audience=consumer |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: where does fluorouracil come from | Answer: dailymed list of manufacturers
For more information, visit: https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=fluorouracil&pagesize=200&page=1 |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: chlorpheniramine how long in system | Answer: Chlorpheniramine has a serum half-life of approximately 20 hours in adults, and elimination from the body is primarily by metabolism to monodesmethyl and didesmethyl compounds. The half-life is increased in the presence of renal dysfunction and decreased in children. The exact mechanism of the presystemic first-pass elimination and the effects of dose levels on the process presently are unclear. Biopharmaceutical and pharmacokinetic studies after single or multiple doses in humans reveal wide interindividual variations in pharmacokinetics. Age, dialysis, urinary pH and flow influence the elimination kinetics of chlorpheniramine.
For more information, visit: https://www.ncbi.nlm.nih.gov/pubmed/6383755 |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: how long will 6 mgs of suboxone block opiates | Answer: Comparisons of buprenorphine with full agonists such as methadone and hydromorphone suggest that sublingual buprenorphine produces typical opioid agonist effects which are limited by a ceiling effect.
In non-dependent subjects, acute sublingual doses of SUBOXONE tablets produced opioid agonist effects, which reached a maximum between doses of 8 mg and 16mg of SUBUTEX. The effects of 16mg SUBOXONE were similar to those produced by 16mg SUBUTEX (buprenorphine alone).
Opioid agonist ceiling effects were also observed in a double-blind, parallel group, dose ranging comparison of single doses of buprenorphine sublingual solution (1, 2, 4, 8, 16, or 32 mg), placebo, and a full agonist control at various doses. The treatments were given in ascending dose order at intervals of at least one week to 16 opioid-experienced, non-dependent subjects. Both drugs produced typical opioid agonist effects. For all the measures for which the drugs produced an effect, buprenorphine produced a dose-related response but, in each case, there was a dose that produced no further effect. In contrast, the highest dose of the full agonist control always produced the greatest effects. Agonist objective rating scores remained elevated for the higher doses of buprenorphine (8-32 mg) longer than for the lower doses and did not return to baseline until 48 hours after drug administrations. The onset of effects appeared more rapidly with buprenorphine than with the full agonist control, with most doses nearing peak effect after 100 minutes for buprenorphine compared to 150 minutes for the full agonist control.
For more information, visit: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a96619d8-5c87-4adc-9446-b6d3cb3d04aa&audience=consumer |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: what is marijuana? | Answer: Marijuana is a green, brown, or gray mix of dried, crumbled parts from the marijuana plant. It can be rolled up and smoked like a cigarette or cigar or smoked in a pipe. Sometimes people mix it in food or inhale it using a vaporizer.
Marijuana can cause problems with memory, learning, and behavior. Smoking it can cause some of the same coughing and breathing problems as smoking cigarettes. Some people get addicted to marijuana after using it for a while. It is more likely to happen if they use marijuana every day, or started using it when they were teenagers.
Some states have approved "medical marijuana" to ease symptoms of various health problems. The U.S. Food and Drug Administration (FDA) has not approved the marijuana plant as a medicine. However, there have been scientific studies of cannabinoids, the chemicals in marijuana. This has led to two FDA-approved medicines. They contain THC, the active ingredient in marijuana. They treat nausea caused by chemotherapy and increase appetite in patients who have severe weight loss from HIV/AIDS. Scientists are doing more research with marijuana and its ingredients to treat many diseases and conditions.
For more information, visit: https://medlineplus.gov/marijuana.html |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: how is marijuana used | Answer: Marijuana is best known as a drug that people smoke or eat to get high. It is derived from the plant Cannabis sativa. Possession of marijuana is illegal under federal law. Medical marijuana refers to using marijuana to treat certain medical conditions. In the United States, about half of the states have legalized marijuana for medical use.
For more information, visit: https://medlineplus.gov/ency/patientinstructions/000899.htm |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: how is tocilizumab administered | Answer: Tocilizumab injection comes as a solution (liquid) to be injected intravenously (into a vein) in your arm by a doctor or nurse in a medical office or hospital outpatient clinic or as a prefilled syringe to inject subcutaneously (under the skin) by yourself at home. When tocilizumab is given intravenously to treat rheumatoid arthritis or polyarticular juvenile idiopathic arthritis, it is usually given once every 4 weeks. When tocilizumab is given intravenously to treat systemic juvenile idiopathic arthritis, it is usually given once every 2 weeks. When tocilizumab is given intravenously to treat cytokine release syndrome, it is usually given once, but up to 3 additional doses may be given at least 8 hours apart. It will take about 1 hour for you to receive your dose of tocilizumab injection intravenously. When tocilizumab is given subcutaneously to treat rheumatoid arthritis or giant cell arteritis, it is usually given once weekly or once every other week.
You will receive your first subcutaneous dose of tocilizumab injection in your doctor's office. If you will be injecting tocilizumab injection subcutaneously by yourself at home or having a friend or relative inject the medication for you, your doctor will show you or the person who will be injecting the medication how to inject it. You and the person who will be injecting the medication should also read the written instructions for use that come with the medication.
Thirty minutes before you are ready to inject tocilizumab injection, you will need to remove the medication from the refrigerator, take it out of its carton, and allow it to reach room temperature. When removing a prefilled syringe from the box, be careful not to touch the trigger fingers on the syringe. Do not try to warm the medication by heating it in a microwave, placing it in warm water, or through any other method.
Do not remove the cap from the prefilled syringe while the medication is warming. You should remove the cap no more than 5 minutes before you inject the medication. Do not replace the cap after you remove it. Do not use the syringe if you drop it on the floor.
Check the prefilled syringe to be sure that the expiration date printed on the package has not passed, Holding the syringe with the covered needle pointing down, look closely at the liquid in the syringe. The liquid should be clear or pale yellow and should not be cloudy or discolored or contain lumps or particles. Call your pharmacist if there are any problems with the package or the syringe and do not inject the medication.
You may inject tocilizumab injection on the front of the thighs or anywhere on your stomach except your navel (belly button) and the area 2 inches around it. If another person is injecting your medication, the outer area of the upper arms also may be used. Do not inject the medication into skin that is tender, bruised, red, hard, or not intact, or that has scars, moles, or bruises. Choose a different spot each time you inject the medication, at least 1 inch away from a spot that you have used before. If the full dose is not injected, call your doctor or pharmacist.
Do not reuse tocilizumab prefilled syringes and do not recap the syringes after use. Discard any used syringes in a puncture-resistant container and ask your pharmacist how to throw away the container.
For more information, visit: https://medlineplus.gov/druginfo/meds/a611004.html |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: what is diclofenac ointment used for | Answer: Diclofenac topical gel (Voltaren) is used to relieve pain from osteoarthritis (arthritis caused by a breakdown of the lining of the joints) in certain joints such as those of the knees, ankles, feet, elbows, wrists, and hands. Diclofenac topical liquid (Pennsaid) is used to relieve osteoarthritis pain in the knees. Diclofenac is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the body's production of a substance that causes pain.
Diclofenac is also available as a 3% gel (Solaraze; generic) that is applied to the skin to treat actinic keratosis (flat, scaly growths on the skin caused by too much sun exposure). This monograph only gives information about diclofenac gel (Voltaren) and liquid (Pennsaid) for osteoarthritis. If you are using diclofenac gel (Solaraze, generic) for actinic keratosis, read the monograph entitled diclofenac topical (actinic keratosis).
For more information, visit: https://medlineplus.gov/druginfo/meds/a611002.html |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: cephalexin is for what sexual diseases | Answer: Cephalexin is used to treat certain infections caused by bacteria such as pneumonia and other respiratory tract infections; and infections of the bone, skin, ears, , genital, and urinary tract. Cephalexin is in a class of medications called cephalosporin antibiotics. It works by killing bacteria.
Antibiotics such as cephalexin will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.
For more information, visit: https://medlineplus.gov/druginfo/meds/a682733.html |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: what is terfenadine | Answer: Terfenadine is a selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.
For more information, visit: https://pubchem.ncbi.nlm.nih.gov/compound/terfenadine#section=Top |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: what is bisolvon | Answer: Bromhexine hydrochloride is a hydrochloride resulting from the reaction of equimolar amounts of bromhexine and hydrogen chloride. It is used as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of sputum). It has a role as a mucolytic. It contains a bromhexine(1+).
For more information, visit: https://pubchem.ncbi.nlm.nih.gov/compound/5702220#section=Top |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: is it safe for a 72 year old to stop taking premarin? | Answer: Use of estrogen-alone, or in combination with a progestin, should be with the lowest effective dose and for the shortest duration consistent with treatment goals and risks for the individual woman. Postmenopausal women should be re-evaluated periodically as clinically appropriate to determine if treatment is still necessary.
For more information, visit: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=258e1602-a3cf-4ccc-ca80-73dbbfb812ff&audience=consumer |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: what are the side effects of taking the two medication amlodipine metoprolol together | Answer: There were six AEs reported in five patients. Peripheral edema 2.97% (3/101) was the most common AE, which was reported in three patients and was related to the study medication, probably to the amlodipine component. All these patients had hemoglobin (Hb) less than 12 g/dL at baseline (one patient had Hb of 11.6 g/dL at baseline, which was 12.1 at end of study and two had 11.7 g/dL which was 11.3 and 12.9 respectively at the end of study). Of these three, one patient had severe peripheral edema and was withdrawn from the study. The patient was followed-up and after a week time peripheral edema was resolved. Peripheral edema of mild and moderate degree was seen in one patient each. In these two patients, edema was resolved and improved respectively. Vertigo, lumbar spondylosis and eosinophilia (considered unlikely due to the study drug), were seen in one patient each and were mild in intensity. Though there were statistically significant changes in sodium, chloride, which showed decrease and blood urea, fasting blood sugar, which were increased, but these were clinically insignificant. Details of laboratory tests are shown in Table 6. The other AEs were of mild severity and not related to the study medication. Table 7 summarizes the AEs.
For more information, visit: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952407/ |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: how soon does losartan affect blood pressure | Answer: The effect of losartan is substantially present within one week but in some studies the maximal effect occurred in 3 to 6 weeks. In long-term follow-up studies (without placebo control) the effect of losartan appeared to be maintained for up to a year.
For more information, visit: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3cdcf8cc-4964-4c53-e054-00144ff88e88&audience=consumer |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: how do steroids effect the respiratory system | Answer: Several efforts have been made to show the beneficial effects of anabolic agents in humans. In malnourished patients suffering from chronic obstructive pulmonary disease (COPD) nandrolone decanoate was beneficial in regaining respiratory muscle strength.74Recent data showed an improvement in expiratory and inspiratory muscle strength following treatment with oxandrolone in patients with tetraplegia.75 This increase in muscle strength was attributed to the observed increase in diaphragm muscle mass and resulted in an increased vital capacity. Basin and co-workers showed a beneficial effect of a high dose of testosterone on fat free body mass, muscle size, and peripheral muscle strength in normal men.76 During the 1970s and 1980s several studies were performed to investigate the additional effects of anabolic steroids on a training programme in healthy athletes. The results of these studies varied from no additional effect on muscle force production and no improvement in aerobic capacity77 78 to a small but significant increase in muscle force.
For more information, visit: https://thorax.bmj.com/content/54/11/1041 |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: why am i so cold taking bystolic b p med | Answer: Feeling cold is found among people who take Bystolic, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Nexium, and have Depression. This study is created by eHealthMe based on reports of 11,671 people who have side effects when taking Bystolic from FDA, and is updated regularly.
For more information, visit: https://www.ehealthme.com/ds/bystolic/feeling-cold/ |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: pneumococcal vaccine how often | Answer: CDC recommends routine administration of pneumococcal conjugate vaccine (PCV13 or Prevnar13®) for all children younger than 2 years of age:
Give PCV13 to infants as a series of 4 doses, one dose at each of these ages: 2 months, 4 months, 6 months, and 12 through 15 months.
Children who miss their shots or start the series later should still get the vaccine. The number of doses recommended and the intervals between doses will depend on the child’s age when vaccination begins.
Immunization Schedules
HCP adult and child schedules
View current schedules for children, teens, and adults.
CDC recommends pneumococcal vaccination (PCV13 or Prevnar13®, and PPSV23 or Pneumovax23®) for all adults 65 years or older:
Give a dose of PCV13 to adults 65 years or older who have not previously received a dose. Then administer a dose of PPSV23 at least 1 year later.
If the patient already received one or more doses of PPSV23, give the dose of PCV13 at least 1 year after they received the most recent dose of PPSV23.
For more information, visit: https://www.cdc.gov/vaccines/vpd/pneumo/hcp/recommendations.html |
The following is a medical question about drug interactions. Provide a detailed answer. | Question: is it alright to use fluticasone when using oxygen | Answer: Pharmacological therapy can influence morbidity and mortality in severe chronic obstructive pulmonary disease (COPD). Long-term domiciliary oxygen therapy (LTOT) improves survival in COPD with chronic hypoxaemia. Oral steroid medication has been associated with improved survival in men and increased mortality in women, while inhaled steroid medication has been associated with a reduction in the exacerbation rate. We have analysed the relationships between pharmacological therapy including oxygen therapy, sex, performance status and need for hospitalization and mortality in 403 patients with COPD (201 men) after their registration in a national oxygen register for LTOT. The mean value of days spent in hospital per year was 44. An increased need of hospital care was independently predicted by a poor performance status, high age and, in women, orally administered steroid medication. Hospital admissions were significantly longer in the terminal stage of COPD among women receiving oral steroid medication. Increased mortality was predicted by a poor performance status and, in women, oral steroid treatment. Predictors of morbidity and mortality during LTOT were found to coincide. The increased mortality in women receiving oral steroid medication was found to be associated with an increased need of hospital care due to longer hospital stays during the terminal stage of the disease. When analysing effects and side-effects of steroid medication in COPD, the possibility of sex-related differences should be considered.
For more information, visit: https://www.ncbi.nlm.nih.gov/pubmed/9519225 |