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0 20 40 60 80 100 0 10 2 10 3 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 20 40 60 80 100 0 10 2 10 3 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 20 40 60 80 100 0 10 2 10 3 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 20 40 60 80 100 0 10 2 10 3 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 Kim et al. Supplemental Fig. 2 MG A 60 80 100 A1/Library A5/Library A4/Library A3/Library A2/Library A6/Library GBM3 TICs GBM4 Non-TICs GBM2 TICs GBM2 Non-TICs C E B D 0 20 40 60 80 100 0 10 2 10 3 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 20 40 60 80 100 0 10 2 10 3 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 20 40 60 80 100 0 10 2 10 3 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 20 40 60 80 100 0 10 2 10 3 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 Kim et al. Supplemental Fig. 0 20 40 60 80 100 0 10 2 10 3 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 20 40 60 80 100 0 10 2 10 3 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 20 40 60 80 100 0 10 2 10 3 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 20 40 60 80 100 0 10 2 10 3 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 Kim et al. Supplemental Fig. 2 MG A 60 80 100 A1/Library A5/Library A4/Library A3/Library A2/Library A6/Library GBM3 TICs GBM4 Non-TICs GBM2 TICs GBM2 Non-TICs C E B D 2 MG A 60 80 100 A1/Library A5/Library A4/Library A3/Library A2/Library A6/Library GBM3 TICs GBM4 Non-TICs GBM2 TICs GBM2 Non-TICs C E B D 0 20 40 60 80 100 0 10 2 10 3 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 A A1/Library A5/Library A4/Library A3/Library A2/Library A6/Library GBM2 TICs B A 0 10 10 0 10 10 0 10 10 0 10 10 0 10 10 0 10 10 0 20 40 60 80 100 0 10 2 10 3 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 GBM2 Non-TICs B B GBM2 Non-TICs 0 20 40 60 0 10 2 10 3 0 20 40 60 0 20 40 60 0 20 40 60 0 20 40 60 0 20 40 60 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 20 40 60 80 100 0 10 2 10 3 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 20 40 60 80 100 0 10 2 10 3 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 U87MG 0 20 40 60 80 100 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 GBM3 TICs GBM4 Non-TICs GBM2 No C E D C 0 20 40 60 80 100 0 10 2 10 3 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 GBM3 TICs C D 0 20 40 60 80 100 0 10 2 10 3 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 20 40 60 80 100 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 GBM4 Non-TICs D E U87MG 0 20 40 60 80 100 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 0 10 2 10 3 E
1,457
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Aptamer_Identification_of_Brain_Tumor_Initiating_Cells/22395543/1/files/39841167.pdf
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Supplemental Figure 2 Supplemental Figure 2 G Cy T-GVAX No Rx Cy/T-GVAX G T-GVAX G T-GVAX Cy Cy/T-GVAX
18
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Cyclophosphamide_Augments_Antitumor_Immunity_Studies_in_an_Autochthonous_Prostate_Cancer_Model/22378428/1/files/39823782.pdf
null
unk
Suppl Suppl Supplemental Figure 2
5
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Cytokine_Receptor_CXCR4_Mediates_Estrogen-Independent_Tumorigenesis_Metastasis_and_Resistance_to_Endocrine_Therapy_in_Human_Breast_Cancer/22388001/1/files/39833478.pdf
null
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1 1 1 1 1 EZ235 (20 mg/Kg) 2 BEZ235 (20 mg/Kg) Control 2 2 2 2
17
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Dual_Inhibition_of_the_PI3K_mTOR_Pathway_Increases_Tumor_Radiosensitivity_by_Normalizing_Tumor_Vasculature/22393160/1/files/39838739.pdf
null
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M14 M14 M14 M14BRR2 M14BRR2 M14BRR2 M14 Figure S2 Figure S2
11
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Elevated_CRAF_as_a_Potential_Mechanism_of_Acquired_Resistance_to_BRAF_Inhibition_in_Melanoma/22371194/1/files/39816287.pdf
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400 600 800 1000 1200 r2 = 0.428 Css min (ng/ml) 400 600 800 1000 1200 r2 = 0.428 Css min (ng/ml)
22
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_First-in-Human_Phase_I_Trial_of_Two_Schedules_of_OSI-930_a_Novel_Multikinase_Inhibitor_Incorporating_Translational_Proof-of-Mechanism_Studies/22449204/1/files/39900267.pdf
null
unk
Hartman_FigS2 Hartman_FigS2 A B Hartman_FigS2 ** ## A B ## A B
12
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_HER2_Overexpression_Elicits_a_Proinflammatory_IL-6_Autocrine_Signaling_Loop_That_Is_Critical_for_Tumorigenesis/22387641/1/files/39833112.pdf
null
unk
gure 2 TUBB3 H-score gure 2 TUBB3 H-score
8
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_High_TUBB3_Expression_an_Independent_Prognostic_Marker_in_Patients_with_Early_Non_Small_Cell_Lung_Cancer_Treated_by_Preoperative_Chemotherapy_Is_Regulated_by_K-Ras_Signaling_Pathway/22497367/1/files/39955714.pdf
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Supplemental Figure 2 siSV1-Cy3 2X siSV1-Cy3 20X siSV1-Cy3 20X 20X Supplemental Figure 2 siSV1-Cy3 2X siSV1-Cy3 20X siSV1-Cy3 20X 20X Supplemental Figure 2 siSV1-Cy3 2X siSV1-Cy3 20X Supplemental Figure 2 siSV1-Cy3 20X 20X 20X
34
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_KLF6-SV1_Is_a_Novel_Antiapoptotic_Protein_That_Targets_the_BH3-Only_Protein_NOXA_for_Degradation_and_Whose_Inhibition_Extends_Survival_in_an_Ovarian_Cancer_Model/22377747/1/files/39823089.pdf
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unk
Vehicle ML264 (2 x 25 mg/kg) Vehicle ML264 (2 x 25 mg/kg) ML264 (2 x 25 mg/kg) ML264 (2 x 25 mg/kg) A Vehicle KLF5 #1 KLF5 #2 KLF5 #3
30
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_ML264_A_Novel_Small-Molecule_Compound_That_Potently_Inhibits_Growth_of_Colorectal_Cancer/22504276/1/files/39963733.pdf
null
unk
UO SB 967 3 MLK3 UO SB p-paxi S178 p paxi S178 paxillin
13
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_MLK3_Regulates_Paxillin_Phosphorylation_in_Chemokine-Mediated_Breast_Cancer_Cell_Migration_and_Invasion_to_Drive_Metastasis/22391699/1/files/39837248.pdf
null
unk
Supplemental Figure 2 Supplemental Figure 2 Supplemental Figure 2 A B A B A B A B
17
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Molecular_Dissection_of_AKT_Activation_in_Lung_Cancer_Cell_Lines/22510207/1/files/39972088.pdf
null
unk
NB1 LOC402592 OSBPL5 LOC389167 SAPS2 HSF1 PAK7 EtOH E2 NB1 LOC402592 OSBPL5 LOC389167 SAPS2 HSF1 PAK7 EtOH E2 1 OC402592 OSBPL5 LOC389167 SAPS2 HSF1 PAK7 EtOH E2
27
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Novel_Estrogen_Receptor-_Binding_Sites_and_Estradiol_Target_Genes_Identified_by_Chromatin_Immunoprecipitation_Cloning_in_Breast_Cancer/22367831/1/files/39812903.pdf
null
unk
2 2
2
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Nupr1-Aurora_Kinase_A_Pathway_Provides_Protection_against_Metabolic_Stress-Mediated_Autophagic-Associated_Cell_Death/22450875/1/files/39901953.pdf
null
unk
Figure S2 Figure S2 Figure S2 Figure S2
8
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Overexpression_of_Mitotic_Centromere_Associated_Kinesin_Stimulates_Microtubule_Detachment_and_Confers_Resistance_to_Paclitaxel/22496881/1/files/39954901.pdf
null
unk
             !  " #                  !  " #    
42
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Paradoxical_Relationship_between_Chromosomal_Instability_and_Survival_Outcome_in_Cancer/22388780/1/files/39834269.pdf
null
unk
Figure S2 Figure S2 A Ki-67 central IHC score Frequency 0 100 200 300 400 0 0.2 0.4 0.6 0.8 1.0 A Ki-67 central IHC score Frequency 0 100 200 300 400 0 0.2 0.4 0.6 0.8 1.0 A A B Ki-67 central IHC score Frequency Ki-67 central IHC score Frequency 0 0 20 40 60 80 100 0 100 200 300 400 0.2 0.4 0.6 0.8 1.0 0 0.2 0.4 0.6 0.8 1.0 Frequency B B Ki-67 central IHC score Frequency 0 0 20 40 60 80 100 0.2 0.4 0.6 0.8 1.0 Frequency Ki-67 central IHC score
99
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Patients_with_Slowly_Proliferative_Early_Breast_Cancer_Have_Low_Five-Year_Recurrence_Rates_in_a_Phase_III_Adjuvant_Trial_of_Capecitabine/22459088/1/files/39910382.pdf
null
unk
A B 4x 10x A B 4x 10x 4x
9
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Pharmacokinetic_Modeling_of_Tumor_Bioluminescence_Implicates_Efflux_and_Not_Influx_as_the_Bigger_Hurdle_in_Cancer_Drug_Therapy/22390686/1/files/39836217.pdf
null
unk
Figure S2
2
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Resveratrol_Inhibits_Proliferation_and_Survival_of_Epstein_Barr_Virus_Infected_Burkitt_s_Lymphoma_Cells_Depending_on_Viral_Latency_Program/22519143/1/files/39981762.pdf
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A. A. A. A. A. A. B. C. D. B. B. C. C. D. D.
15
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Reversal_of_NK-Cell_Exhaustion_in_Advanced_Melanoma_by_Tim-3_Blockade/22538039/1/files/40001342.pdf
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FIGURE S2 DAPI IEC-6-MEK1DD pERK1/2 DAPI C C+N N 0 25 50 75 100 pMEK1/2 pERK1/2 (% Cells) pMEK1/2 FIGURE S2 DAPI IEC-6-MEK1DD pERK1/2 DAPI C C+N N 0 25 50 75 100 pMEK1/2 pERK1/2 (% Cells) pMEK1/2 FIGURE S2 FIGURE S2 DAPI IEC-6-MEK1DD pERK1/2 DAPI C C+N N 0 25 50 75 100 pMEK1/2 pERK1/2 (% Cells) pMEK1/2 IEC-6-MEK1DD
60
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Sef_Downregulation_by_Ras_Causes_MEK1_2_to_Become_Aberrantly_Nuclear_Localized_Leading_to_Polyploidy_and_Neoplastic_Transformation/22395305/1/files/39840932.pdf
null
unk
Supplemental Figure S2 Supplemental Figure S2 D A B B D C D
13
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Serum_Glutamate_Levels_Correlate_with_Gleason_Score_and_Glutamate_Blockade_Decreases_Proliferation_Migration_and_Invasion_and_Induces_Apoptosis_in_Prostate_Cancer_Cells/22446156/1/files/39897204.pdf
null
unk
Supplemental Figure 2 Supplemental Figure 2 Supplemental Figure 2 pp g
11
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Temozolomide-Mediated_Radiosensitization_of_Human_Glioma_Cells_in_a_Zebrafish_Embryonic_System/22376133/1/files/39821433.pdf
null
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Suppl. Fig. 2 Suppl. Fig. 2 Suppl. Fig. 2 A ** A B a b c d B a b B A c d c a b d d ** b
31
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_The_Activation_of_MEK_ERK_Signaling_Pathway_by_Bone_Morphogenetic_Protein_4_to_Increase_Hepatocellular_Carcinoma_Cell_Proliferation_and_Migration/22516791/1/files/39979365.pdf
null
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0 3 6 9 2 5 8 Normal Tumor T24 control T24 miR101 TCCSUP control TCCSUP miR101 UMUC3 control UMUC3 miR101 UMUC3 control 5nM UMUC3 miR101 5nM 0 3 6 9 2 5 8 Normal Tumor T24 control T24 miR101 TCCSUP control TCCSUP miR101 UMUC3 control UMUC3 miR101 UMUC3 control 5nM UMUC3 miR101 5nM
54
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_The_Putative_Tumor_Suppressor_microRNA-101_Modulates_the_Cancer_Epigenome_by_Repressing_the_Polycomb_Group_Protein_EZH2/22380654/1/files/39826059.pdf
null
unk
Supplemental Figure S2 Supplemental Figure S2 Supplemental Figure S2
9
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Threonine_2609_Phosphorylation_of_the_DNA-Dependent_Protein_Kinase_Is_a_Critical_Prerequisite_for_Epidermal_Growth_Factor_Receptor_Mediated_Radiation_Resistance/22516561/1/files/39979129.pdf
null
unk
A B A B A B A B B A
10
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Triptolide_Induces_the_Expression_of_miR-142-3p_A_Negative_Regulator_of_Heat_Shock_Protein_70_and_Pancreatic_Cancer_Cell_Proliferation/22500373/1/files/39959641.pdf
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Figure S2 cell number (x10^6) control-Ig 13F3 0.0 0.5 1.0 1.5 2.0 2.5 viable cells% control-Ig 13F3 0 20 40 60 80 100 control-Ig 13F3 cell number (x10^6) control-Ig 13F3 0.0 0.5 1.0 1.5 2.0 2.5 viable cells% control-Ig 13F3 0 20 40 60 80 100 control-Ig 13F3
48
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_VISTA_Regulates_the_Development_of_Protective_Antitumor_Immunity/22401467/1/files/39847259.pdf
null
unk
Serum PDGF 0 2 5 8 12 2 5 8 12 eIF4E eIF4AI eIF4GI c-Myc EF-1 Time (h): 1 2 3 4 5 6 7 8 9 Serum PDGF 0 2 5 8 12 2 5 8 12 eIF4E eIF4AI eIF4GI c-Myc EF-1 Time (h): 1 2 3 4 5 6 7 8 9 Serum PDGF 0 2 5 8 12 2 5 8 12 eIF4E eIF4AI eIF4GI c-Myc EF-1 Time (h): 1 2 3 4 5 6 7 8 9
81
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_c-Myc_and_eIF4F_Are_Components_of_a_Feedforward_Loop_that_Links_Transcription_and_Translation/22374612/1/files/39819852.pdf
null
unk
GFP miR-31 Alpha Beta3 Alpha Beta1 Alpha * * * * * GFP miR-31 Alpha Beta3 Alpha Beta1 Alpha * * * * *
24
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_miR-31_Is_a_Broad_Regulator_of_1-Integrin_Expression_and_Function_in_Cancer_Cells/22519228/1/files/39981847.pdf
null
unk
20000 40000 luore 0 20000 OSC-78 OSC-83 OS-85 OS-93 Fl OS-85 OSC-78 OS-93 OSC-83 20000 40000 luore 0 20000 OSC-78 OSC-83 OS-85 OS-93 Fl OS-85 OSC-78 OS-93 OSC-83 93 OS-85 OS-93 20000 0 20000 OSC-78 OSC-83 OS-85 OS-9 20000 0 20000 OSC-78 OSC-83 OS-85 OS OSC-78 OSC-83 -78 83 SC-83 OS-85 O 800 1000
54
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_A_Mutation_Threshold_Distinguishes_the_Antitumorigenic_Effects_of_the_Mitochondrial_Gene_i_MTND1_i_an_i_Oncojanus_i_Function/22388781/1/files/39834270.pdf
null
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Figure Supplement 3 Figure Supplement 3 Figure Supplement 3
9
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_A_Phase_II_and_Biomarker_Study_of_Ramucirumab_a_Human_Monoclonal_Antibody_Targeting_the_VEGF_Receptor-2_as_First-Line_Monotherapy_in_Patients_with_Advanced_Hepatocellular_Cancer/22448427/1/files/39899472.pdf
null
unk
D D D D
4
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_A_Survivin-Associated_Adaptive_Response_in_Radiation_Therapy/22395008/1/files/39840629.pdf
null
unk
B B
2
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Activation_of_the_Wnt_Pathway_through_AR79_a_GSK3_Inhibitor_Promotes_Prostate_Cancer_Growth_in_Soft_Tissue_and_Bone/22509195/1/files/39971073.pdf
null
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$%&'()!*+! $%&'()!*+! ! "! #! $%&'( p=0.025 *p=0.007 p=0.005 *p=0.002 p=0.328 n=46 n=46 n=36 "! $%&'()!*+! p=0.005 *p=0.002 .328 n=46 n=46 "! $%&' p=0.005 *p=0.002 n=46 ! p=0.328 n=46 "! ! ! #! p=0.025 *p=0.007 n=36 #!
37
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Alternate_Splicing_of_the_p53_Inhibitor_HDMX_Offers_a_Superior_Prognostic_Biomarker_than_p53_Mutation_in_Human_Cancer/22391741/1/files/39837290.pdf
null
unk
  
3
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Alternative_Cleavage_and_Polyadenylation_during_Colorectal_Cancer_Development/22452587/1/files/39903662.pdf
null
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Supplemental Fig 3 . B. C. B. C. B. A. C.
11
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_An_Epithelial_Mesenchymal_Transition_Gene_Signature_Predicts_Resistance_to_EGFR_and_PI3K_Inhibitors_and_Identifies_Axl_as_a_Therapeutic_Target_for_Overcoming_EGFR_Inhibitor_Resistance/22446704/1/files/39897749.pdf
null
unk
b b
2
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Antigen_Shedding_May_Improve_Efficiencies_for_Delivery_of_Antibody-Based_Anticancer_Agents_in_Solid_Tumors/22393442/1/files/39839027.pdf
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Supplementary Figure 3 Supplementary Figure 3 -9 -8 -7 -6 -5 0.00 0.25 0.50 0.75 1.00 1.25 Log [navitoclax] (M) Fraction alive -8 -7 -6 -5 -4 0.00 0.25 0.50 0.75 1.00 1.25 Log [A-1331852] (M) Fraction alive CAL1 THP1 TF1 U937 MOLM13 KASUMI1 OCI-AML2 CAL1 THP1 TF1 U937 MOLM13 KASUMI1 OCI-AML2 -9 -8 -7 -6 -5 0.00 0.25 0.50 0.75 1.00 1.25 Log [navitoclax] (M) Fraction alive CAL1 THP1 TF1 U937 MOLM13 KASUMI1 OCI-AML2 -8 -7 -6 -5 -4 0.00 0.25 0.50 0.75 1.00 1.25 Log [A-1331852] (M) Fraction alive CAL1 THP1 TF1 U937 MOLM13 KASUMI1 OCI-AML2
98
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Blastic_Plasmacytoid_Dendritic_Cell_Neoplasm_Is_Dependent_on_BCL2_and_Sensitive_to_Venetoclax/22531389/1/files/39994566.pdf
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P=0.0095 P<0.0001 A B C Figure S3 P=0.0095 P<0.0001 A B C Figure S3 A A P=0.0095 B B P<0.0001 C C Figure S3
24
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Common_and_Overlapping_Oncogenic_Pathways_Contribute_to_the_Evolution_of_Acute_Myeloid_Leukemias/22388187/1/files/39833664.pdf
null
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Supplemental Figure 3 Supplemental Figure 3
6
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Cytokine_Receptor_CXCR4_Mediates_Estrogen-Independent_Tumorigenesis_Metastasis_and_Resistance_to_Endocrine_Therapy_in_Human_Breast_Cancer/22387998/1/files/39833475.pdf
null
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1 1 1 1
4
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Dual_Inhibition_of_the_PI3K_mTOR_Pathway_Increases_Tumor_Radiosensitivity_by_Normalizing_Tumor_Vasculature/22393154/1/files/39838733.pdf
null
unk
A B A B A B B
7
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_HER2-Associated_Radioresistance_of_Breast_Cancer_Stem_Cells_Isolated_from_HER2-Negative_Breast_Cancer_Cells/22451729/1/files/39902804.pdf
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20 40 Weeks AUC 0.64 AUC 0.7 60 100 80 20 40 Weeks AUC 0.64 AUC 0.7 60 100 80 20 40 Weeks 60
24
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Hsa-miR-31-3p_Expression_Is_Linked_to_Progression-free_Survival_in_Patients_with_KRAS_Wild-type_Metastatic_Colorectal_Cancer_Treated_with_Anti-EGFR_Therapy/22450919/1/files/39902000.pdf
null
unk
A B
2
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Identification_of_Anaplastic_Lymphoma_Kinase_as_a_Potential_Therapeutic_Target_in_Ovarian_Cancer/22389594/1/files/39835110.pdf
null
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Supplemental Fig. 3 Supplemental Fig. 3 SKBR3 p-mTOR (S2448) p-TSC2 (T1462) pan mTOR - + - + - + Rapa INK control HRG p ( ) p-AKT (T308) p-AKT (S473) pan AKT pan TSC2 pan AKT
36
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Identification_of_mTORC2_as_a_Necessary_Component_of_HRG_ErbB2-Dependent_Cellular_Transformation/22511302/1/files/39973267.pdf
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A. Sanford et. al. Supplementary Figure S3 B. C. A. Sanford et. al. Supplementary Figure S3 B. C. A. Sanford et. al. Supplementary Figure S3 A. B. C. B. B. C. C.
32
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Inflammatory_Monocyte_Mobilization_Decreases_Patient_Survival_in_Pancreatic_Cancer_A_Role_for_Targeting_the_CCL2_CCR2_Axis/22452632/1/files/39903707.pdf
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B BT549 #2 p-JNK MLK3 CXCL12 S178 K p-paxi S178 JNK n actin paxillin p-ERK B BT549 p-JNK MLK3 CXCL12 p-paxi S178 JNK actin paxillin p-ERK
26
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_MLK3_Regulates_Paxillin_Phosphorylation_in_Chemokine-Mediated_Breast_Cancer_Cell_Migration_and_Invasion_to_Drive_Metastasis/22391696/1/files/39837242.pdf
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ntal Figure 3 Supplemental Figure 3 mental Figure 3 Supplemental Figure 3
12
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_MicroRNA-205_Inhibits_Src-Mediated_Oncogenic_Pathways_in_Renal_Cancer/22389456/1/files/39834972.pdf
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Supplemental Figure 3 Supplemental Figure 3
6
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Molecular_Dissection_of_AKT_Activation_in_Lung_Cancer_Cell_Lines/22510204/1/files/39972085.pdf
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Figure S3. Figure S3. Figure S3.
6
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Molecular_Photoacoustic_Imaging_of_Follicular_Thyroid_Carcinoma/22450770/1/files/39901848.pdf
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ACNB1 LOC402592 OSBPL5 LOC389167 SAPS2 HSF1 PAK7 EtOH E2 ACNB1 LOC402592 OSBPL5 LOC389167 SAPS2 HSF1 PAK7 EtOH E2 CNB1 LOC402592 OSBPL5 LOC389167 SAPS2 HSF1 PAK7 E2
26
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Novel_Estrogen_Receptor-_Binding_Sites_and_Estradiol_Target_Genes_Identified_by_Chromatin_Immunoprecipitation_Cloning_in_Breast_Cancer/22367828/1/files/39812900.pdf
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FLAG Actin Tet G418R PtxR - + - Figure S3 FLAG Actin Tet G418R PtxR - + - Figure S3 Figure S3
22
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Overexpression_of_Mitotic_Centromere_Associated_Kinesin_Stimulates_Microtubule_Detachment_and_Confers_Resistance_to_Paclitaxel/22496878/1/files/39954898.pdf
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126
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Paradoxical_Relationship_between_Chromosomal_Instability_and_Survival_Outcome_in_Cancer/22388777/1/files/39834266.pdf
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Ran_FigS3 Ran_FigS3 Ran_FigS3 A B A B A A B B
11
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Proliferation-Independent_Control_of_Tumor_Glycolysis_by_PDGFR-Mediated_AKT_Activation/22398918/1/files/39844644.pdf
null
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Figure S3 Figure S3 Figure S3 Figure S3
8
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Resveratrol_Inhibits_Proliferation_and_Survival_of_Epstein_Barr_Virus_Infected_Burkitt_s_Lymphoma_Cells_Depending_on_Viral_Latency_Program/22519140/1/files/39981759.pdf
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A. B.B. C. D. A. B.B. C. D. A. A. A. B.B. C. D. FIG. S3 B.B. B.B. C. C. D. D.
22
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Reversal_of_NK-Cell_Exhaustion_in_Advanced_Melanoma_by_Tim-3_Blockade/22538036/1/files/40001339.pdf
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unk
Supplemental Figure 3 Supplemental Figure 3 Control 0.0 0.4 0.8 50 0.0 0.4 0.8 100 0.0 0.4 0.8 150 0.0 0.4 0.8 200 0.0 0.4 0.8 250 0.0 0.4 0.8 300 Resveratrol Control Resveratrol Control Resveratrol Control Resveratrol Control Resveratrol Control Resveratrol SIRTl1 Pathway Activation D. GSE9008 0.0 0.4 0.8 0.0 0.4 0.8 0.0 0.4 0.8 0.0 0.4 0.8 0.0 0.4 0.8 0.0 0.4 0.8 SIRTl1 Pathway Activation Control TSC Control TSC A549 Calu-6 Control TSC Control TSC A549 Calu-6 Control TSC Control TSC A549 Calu-6 Control TSC Control TSC A549 Calu-6 Control TSC Control TSC A549 Calu-6 Control TSC Control TSC A549 Calu-6 E. GSE13309 0.0 0.4 0.8 0.0 0.4 0.8 0.0 0.4 0.8 0.0 0.4 0.8 0.0 0.4 0.8 0.0 0.4 0.8 Luciferase SIRT1 Knockdown Luciferase SIRT1 Knockdown Luciferase SIRT1 Knockdown Luciferase SIRT1 Knockdown Luciferase SIRT1 Knockdown Luciferase SIRT1 Knockdown SIRTl1 Pathway Activation F. Supplemental Figure 3 GSE13459 0.0 0.4 0.8 0.0 0.4 0.8 0.0 0.4 0.8 0.0 0.4 0.8 0.0 0.4 0.8 0.0 0.4 0.8 IR exposure Pre- Post-2h Post-4h Post-8h Post-12h Post-24h H1299 H460 Pre- Post-2h Post-4h Post-8h Post-12h Post-24h IR exposure Pre- Post-2h Post-4h Post-8h Post-12h Post-24h H1299 H460 Pre- Post-2h Post-4h Post-8h Post-12h Post-24h IR exposure Pre- Post-2h Post-4h Post-8h Post-12h Post-24h H1299 H460 Pre- Post-2h Post-4h Post-8h Post-12h Post-24h IR exposure Pre- Post-2h Post-4h Post-8h Post-12h Post-24h H1299 H460 Pre- Post-2h Post-4h Post-8h Post-12h Post-24h IR exposure Pre- Post-2h Post-4h Post-8h Post-12h Post-24h H1299 H460 Pre- Post-2h Post-4h Post-8h Post-12h Post-24h IR exposure Pre- Post-2h Post-4h Post-8h Post-12h Post-24h H1299 H460 Pre- Post-2h Post-4h Post-8h Post-12h Post-24h 0.0 0.4 0.8 0.0 0.4 0.8 0.0 0.4 0.8 0.0 0.4 0.8 0.0 0.4 0.8 0.0 0.4 0.8 Se Deficient 0.08ug Se 0.24ug Se 0.8ug Se 2ug Se 5ug Se Se Deficient 0.08ug Se 0.24ug Se 0.8ug Se 2ug Se 5ug Se Se Deficient 0.08ug Se 0.24ug Se 0.8ug Se 2ug Se 5ug Se Se Deficient 0.08ug Se 0.24ug Se 0.8ug Se 2ug Se 5ug Se Se Deficient 0.08ug Se 0.24ug Se 0.8ug Se 2ug Se 5ug Se Se Deficient 0.08ug Se 0.24ug Se 0.8ug Se 2ug Se 5ug Se ATM Pathway Activation GPX1 Pathway Activation 0.0 0.4 0.8 0.0 0.4 0.8 0.0 0.4 0.8 0.0 0.4 0.8 0.0 0.4 0.8 0.0 0.4 0.8 None MAP3K14 IKBKB None MAP3K14 IKBKB H929 SACHI None MAP3K14 IKBKB None MAP3K14 IKBKB H929 SACHI None MAP3K14 IKBKB None MAP3K14 IKBKB H929 SACHI None MAP3K14 IKBKB None MAP3K14 IKBKB H929 SACHI None MAP3K14 IKBKB None MAP3K14 IKBKB H929 SACHI None MAP3K14 IKBKB None MAP3K14 IKBKB H929 SACHI IKBKB Pathway Activation A. GSE20549 B. GSE23895 C. GSE18047 pp g 100 0.0 0.4 0.8 IR exposure Pre- Post-2h Post-4h Post-8h Post-12h Post-24h H1299 H460 Pre- Post-2h Post-4h Post-8h Post-12h Post-24h p 0.0 0.4 0.8 Se Deficient 0.08ug Se 0.24ug Se 0.8ug Se 2ug Se 5ug Se GPX1 Pathway Activation B. Supplemental Figure 3 GSE23895 0.0 0.4 0.8 0.0 0.4 0.8 Se Deficient 0.08ug Se 0.24ug Se 0.8ug Se 2ug Se 5ug Se Se Deficient 0.08ug Se 0.24ug Se 0.8ug Se 2ug Se 5ug Se 0.0 0.4 0.8 Se Deficient 0.08ug Se 0.24ug Se 0.8ug Se 2ug Se 5ug Se 0.0 0.4 0.8 Se Deficient 0.08ug Se 0.24ug Se 0.8ug Se 2ug Se 5ug Se 0.0 0.4 0.8 Se Deficient 0.08ug Se 0.24ug Se 0.8ug Se 2ug Se 5ug Se D GSE9008 Se 0.0 0.4 0.8 None MAP3K14 IKBKB None MAP3K14 IKBKB H929 SACHI IKBKB Pathway Activation C. GSE18047 0.0 0.4 0.8 None MAP3K14 IKBKB None MAP3K14 IKBKB H929 SACHI 0.0 0.4 0.8 None MAP3K14 IKBKB None MAP3K14 IKBKB H929 SACHI 0.0 0.4 0.8 None MAP3K14 IKBKB None MAP3K14 IKBKB H929 SACHI 0.0 0.4 0.8 I None MAP3K14 IKBKB None MAP3K14 IKBKB H929 SACHI 0.8 0.8
622
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_SIRT1_Pathway_Dysregulation_in_the_Smoke-Exposed_Airway_Epithelium_and_Lung_Tumor_Tissue/22393869/1/files/39839460.pdf
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Supplemental Figure S3 Supplemental Figure S3 B D B D B A B A B D D C
18
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Serum_Glutamate_Levels_Correlate_with_Gleason_Score_and_Glutamate_Blockade_Decreases_Proliferation_Migration_and_Invasion_and_Induces_Apoptosis_in_Prostate_Cancer_Cells/22446153/1/files/39897201.pdf
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3 3
2
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Sirtuin_1_Is_Upregulated_in_a_Subset_of_Hepatocellular_Carcinomas_where_It_Is_Essential_for_Telomere_Maintenance_and_Tumor_Cell_Growth/22388603/1/files/39834092.pdf
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b b b b
4
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_The_Activation_of_MEK_ERK_Signaling_Pathway_by_Bone_Morphogenetic_Protein_4_to_Increase_Hepatocellular_Carcinoma_Cell_Proliferation_and_Migration/22516788/1/files/39979362.pdf
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G2/M Cells (%) 0 20 40 60 80 100 10 uM 15 uM G1 S DMSO 20 uM 20 nM Rap Sertraline Suppl. Figure 3 G2/M Cells (%) 0 20 40 60 80 100 10 uM 15 uM G1 S DMSO 20 uM 20 nM Rap Sertraline Suppl. Figure 3 G2/M Cells (%) 0 20 40 60 80 100 10 uM 15 uM G1 S DMSO 20 uM 20 nM Rap Sertraline Suppl. Figure 3 G2/M Cells (%) 0 20 40 60 80 100 10 uM 15 uM G1 S DMSO 20 uM 20 nM Rap Sertraline Suppl. Figure 3
100
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_The_Antidepressant_Sertraline_Inhibits_Translation_Initiation_by_Curtailing_Mammalian_Target_of_Rapamycin_Signaling/22386704/1/files/39832172.pdf
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CUED MEMORY
2
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_The_Effects_of_Chemotherapy_on_Cognitive_Function_in_a_Mouse_Model_A_Prospective_Study/22446003/1/files/39897048.pdf
null
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Supplemental Figure S3 Supplemental Figure S3
6
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Therapeutic_Efficacy_of_an_Fc-Enhanced_TCR-like_Antibody_to_the_Intracellular_WT1_Oncoprotein/22451916/1/files/39902994.pdf
null
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Supplemental Figure S3 Supplemental Figure S3
6
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Threonine_2609_Phosphorylation_of_the_DNA-Dependent_Protein_Kinase_Is_a_Critical_Prerequisite_for_Epidermal_Growth_Factor_Receptor_Mediated_Radiation_Resistance/22516558/1/files/39979126.pdf
null
unk
Actin Rad51 TGF-β1 - - + + + - - + + + 24h 48h 72h 24h 72h 48h NC104 ..PD6 NC104-E6E7 PD20 . NC105 ..PD6 NC105-E6E7 PD20 . Actin Rad51 TGF-β1 - - + + + - - + + + 24h 48h 72h 24h 72h 48h NC104 ..PD6 NC104-E6E7 PD20 . NC105 ..PD6 NC105-E6E7 PD20 . Deng Supplementary Fig. S3 Actin Rad51 TGF-β1 - - + + + - - + + + 24h 48h 72h 24h 72h 48h NC104 ..PD6 NC104-E6E7 PD20 . NC105 ..PD6 NC105-E6E7 PD20 . Actin Rad51 TGF-β1 - - + + + - - + + + 24h 48h 72h 24h 72h 48h NC104 ..PD6 NC104-E6E7 PD20 . NC105 ..PD6 NC105-E6E7 PD20 . Deng Supplementary Fig. S3 Deng Supplementary Fig. S3
128
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Transforming_Growth_Factor_1_Promotes_Chromosomal_Instability_in_Human_Papillomavirus_16_E6E7_Infected_Cervical_Epithelial_Cells/22371150/1/files/39816243.pdf
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A B C A B C A A A B C plemental Figure S3 B B C C C Supplemental Figure S3
22
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Triptolide_Induces_the_Expression_of_miR-142-3p_A_Negative_Regulator_of_Heat_Shock_Protein_70_and_Pancreatic_Cancer_Cell_Proliferation/22500370/1/files/39959638.pdf
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eIF4GIwt/Luc eIF4AIwt/Luc pBabe pBabe-Myc pBabe-Myc/BR .5 1 .5 0 .0 pBabe pBabe-Myc pBabe-Myc/BR
13
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_c-Myc_and_eIF4F_Are_Components_of_a_Feedforward_Loop_that_Links_Transcription_and_Translation/22374609/1/files/39819849.pdf
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5 ITGAV ITGB1 ITGB3 ITGB5 Figu 5 ITGAV ITGB1 ITGB3 ITGB5 Figu
12
https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_miR-31_Is_a_Broad_Regulator_of_1-Integrin_Expression_and_Function_in_Cancer_Cells/22519225/1/files/39981844.pdf
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unk
C60_1.TG C54_0.TG C64_1.TG C56_3.TG C58_0.TG C62_0.TG C58_1.TG C58_3.TG C50_3.TG C64_2.TG C40_0.TG C42_0.TG C42_1.TG C44_3.TG C54_5.TG C40_1.TG C44_4.TG C46_3.TG C40_0.DG C38_0.TG C40_1.DG C42_1.DG C64_3.TG C50_4.TG C30_0.DG C50_5.TG C54_1.TG C56_1.TG C46_4.TG C50_6.TG C62_4.TG C56_5.TG C56_2.TG C48_1.TG C58_5.TG C58_8.TG C46_0.TG C62_3.TG C56_0.TG C48_2.TG C56_6.TG C50_1.TG C54_6.TG C52_1.TG C58_4.TG C52_5.TG C54_7.TG C48_0.TG C56_8.TG C36_0.aDG C58_2.TG C32_0.DG C56_4.TG C50_2.TG C52_4.TG C54_4.TG C62_5.TG C40_2.TG C58_9.TG C48_4.TG C42_3.TG C52_6.TG C42_2.TG C44_0.TG C56_7.TG C44_1.TG C48_3.TG C52_7.TG C38_1.TG C44_2.TG C58_6.TG C42_0.DG C58_7.TG C46_1.TG C46_2.TG C34_0.DG C50_0.TG C62_1.TG C54_2.TG C60_2.TG C60_4.TG C32_0.aDG C52_3.TG C60_0.TG C60_3.TG C62_2.TG C52_0.TG C34_0.aDG C52_2.TG C32_2.aDG C18_2.MG C34_1.aDG C34_2.aDG C36_0.DG C24_0.FA C38_6.DG C16_0.MG C36_3.aDG C38_1.DG C18_0.MG C36_1.aDG C18_1.MG C36_1.DG C54_3.TG C32_1.aDG C34_3.aDG C30_1.aDG C36_4.aDG C22_2.FA C22_1.FA C40_3.DG C44_1.DG C20_2.FA C20_3.FA C22_3.FA C20_4.FA C34_4.aDG C42_2.DG C18_0.FaCN C20_1.FA C40_7.aDG C22_4.FA C44_2.DG C40_6.DG C30_2.aDG C22_6.FA C40_5.DG C18_0.FA C38_5.DG C22_5.FA C40_2.DG C18_1.FA C26_1.FA C30_1.DG C38_2.DG C32_3.aDG C36_2.DG C18_2.FA C24_1.FA C38_3.DG C38_4.DG C14_1.FA C16_0.FA C32_2.DG C32_1.DG C36_2.aDG C34_1.DG C40_7.DG C26_0.FA C38_6.aDG C38_4.aDG C38_5.aDG C38_3.aDG C36_3.DG C14_0.FA C16_0.FaCN C16_1.FA C34_2.DG C16_1.MG C34_3.DG C40_6.aDG C36_5.aDG C40_4.DG C38_2.aDG C40_5.aDG ID C36_0.PI C14_1.aLPC C16_0.LPA C40_0.PS C38_0.PI C30_1.PA C18_0.LPA C40_3.PA C40_4.PA C34_0.PA C28_0.PA C30_0.PA C32_0.PA C26_0.PC C26_0.PA C32_2.PA C16_2.aLPC C40_5.PE C28_1.PA C36_0.PA C16_0.aLPC C44_6.aPE C40_1.PE C42_1.PE C42_4.PC C36_4.aPC C36_5.aPC C40_3.aPC C28_0.PC C42_6.PC C20_0.LPC C32_0.PI C18_0.LPC C40_4.aPC C36_1.aPE C44_6.PC C36_6.PE C30_0.PI C30_2.aPC C34_1.PA C34_2.PA C38_7.aPC C36_3.PA C44_7.PC C32_1.PA C42_5.PA C36_0.PE C34_0.PC C42_6.PS C20_2.LPC C20_3.LPC C42_9.PE C42_7.PI C14_0.LPC C30_1.PS C20_4.LPC C34_3.PS C38_4.PA C40_8.PI C16_1.LPC C18_3.aLPC C28_1.PE C62_3.CL C42_7.PE C34_4.PC C74_8.CL C18_1.LPC C18_2.LPC C36_4.PS C28_0.PE C40_3.PG C40_4.PG C38_7.PG C38_5.PS C70_5.CL C40_8.PC C40_9.aPE C38_7.PC C40_5.PG C40_9.PI C72_6.CL C34_4.PE C40_7.PG C42_8.PE C40_6.PG C42_6.PA C74_7.CL C30_0.PE C38_3.PS C42_8.aPE C72_7.CL C44_7.aPE C40_7.PE C66_5.CL C32_1.PE C70_3.CL C42_4.PI C74_6.CL C30_2.PC C70_6.CL C20_1.LPC C28_0.LPC C38_6.PG C72_8.CL C42_5.aPE C40_9.PE C72_5.CL C34_1.PE C68_5.CL C30_1.PE C74_9.CL C16_1.aLPC C38_6.PS C70_7.CL C42_6.PE C66_4.CL C38_2.PS C38_1.PG C38_4.PG C40_6.PA C38_5.PG C32_2.PE C34_2.PS C36_5.PI C68_6.CL C38_2.PG C36_1.PS C32_2.PI C40_6.PS C40_7.PS C38_3.PG C70_4.CL C36_2.PA C68_4.CL C34_3.PI C38_4.PS C66_2.CL C34_1.PS C40_4.PS C34_3.PC C36_2.PS C42_6.aPC C12_0.LPC C42_2.PS C66_3.CL C32_0.PE C34_1.PG C36_4.PG C32_1.PS C18_1.aLPC C30_2.aPE C36_4.PI C64_4.CL C34_2.PE C16_0.LPC C42_4.PE C36_6.aPE C38_4.aPC C24_0.aLPC C36_3.aPC C38_3.aPE C30_1.aPC C36_4.aPE C18_1.LPA C38_6.aPC C38_5.aPC C40_5.PA C38_2.aPC C28_1.PC C40_4.PE C38_2.aPE C40_3.PE C38_6.PE C38_4.PE C38_4.aPE C36_2.aPC C68_3.CL C36_6.aPC C42_2.PE C42_5.PI C30_0.PC C42_4.aPC C38_1.aPC C40_7.aPC C34_1.aPE C40_8.aPC C42_6.PI C40_6.aPC C74_5.CL C20_1.aLPC C38_3.aPC C40_5.aPC C40_3.PC C38_3.PE C38_3.PA C40_6.PC C42_3.PE C40_5.PC C38_5.PE C42_5.PS C42_5.PC C32_1.aPC C40_7.PI C36_4.PE C34_0.PI C38_4.PC C38_1.PE C38_1.PC C38_6.PC C22_0.aLPC C30_0.PG C38_2.PE C42_5.PE C26_0.aPC C40_1.aPC C44_5.PC C30_0.aPC C40_2.PC C34_1.aPC C40_2.PE C40_4.PC C36_2.aPE C32_2.aPC C34_2.aPC C40_5.PI C40_4.PI C34_0.PS C40_6.PI C42_7.PC C36_5.aPE C36_5.PE C32_0.PC C38_3.PC C36_1.aPC C36_3.aPE C30_1.PC C32_2.aPE C36_3.PE C40_8.PE C36_6.PC C38_3.PI C40_2.PS C32_1.PI C36_3.PI C24_0.LPC C30_0.aPE C42_7.aPC C36_2.PI C34_0.aPC C36_1.PG C34_2.PC C40_2.aPC C26_1.LPC C40_1.PS C28_1.aPE C42_7.aPE C24_1.LPC C42_4.aPE C34_1.PI C34_1.PC C34_3.PE C34_2.PI C34_3.PG C32_1.PC C34_2.PG C40_7.PC C36_2.PE C40_3.PS C36_3.PG C32_2.PG C36_3.PS C34_0.PG C40_6.aPE C32_2.PC C40_7.aPE C28_2.aPE C38_2.PI C42_6.aPE C38_1.PS C40_8.aPE C40_5.PS C36_2.PG C30_1.PI C36_5.PG C20_0.aLPC C36_0.PG C72_4.CL C34_3.aPC C42_4.PS C32_0.aPC C40_3.aPE C40_3.PI C34_4.aPE C38_5.PC C28_0.aPC C38_7.PE C32_0.PG C38_5.aPE C38_2.PA C32_0.aPE C38_5.PI C32_0.PS C14_0.aLPC C64_3.CL C30_1.PG C42_5.aPC C36_1.PI C34_2.aPE C38_6.aPE C36_5.PC C36_1.PC C32_1.aPE C44_8.aPE C40_2.PI C36_3.PC C38_2.PC C22_2.aLPC C38_7.aPE C40_5.aPE C30_0.PS C34_3.aPE C36_1.PA C38_6.PI C36_4.PC C42_7.PA C32_3.PC C32_1.PG C28_0.PS C38_1.PI C44_5.aPE C42_1.PS C38_4.PI C34_0.PE C36_1.PE C40_6.PE C40_4.aPE C30_1.aPE C36_2.PC C18_2.aLPC ID C38_1.TG C30_2.aDG C38_3.aDG C40_5.aDG C18_0.FaCN C32_1.aDG C36_5.aDG C18_0.FA C38_5.aDG C38_4.aDG C40_7.aDG C32_2.aDG C14_1.FA C38_6.aDG C16_0.FA C34_2.DG C34_3.DG C30_1.DG C38_4.DG C40_6.aDG C32_1.DG C32_0.aDG C32_2.DG C36_2.aDG C14_0.FA C16_1.FA C36_4.DG C38_0.TG C34_3.aDG 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C30_0.aPC C38_0.PI C36_1.aPC C34_1.aPE C36_0.PE C20_0.LPC C40_3.PA C40_3.aPE C36_4.aPC C30_2.aPE C26_0.PA C36_1.aPE C16_0.LPA C40_3.aPC C26_0.PC C32_0.PA C38_3.aPE C36_6.PC C30_0.PA C38_4.aPC C38_4.aPE C40_6.aPC C18_0.LPA C42_1.PE C28_1.PA C36_2.aPC C38_7.aPC C42_3.PE C38_2.aPE C40_0.PS C36_6.aPE C30_1.PA C38_6.aPC C40_4.aPC C38_5.aPC C42_5.aPC C14_0.aLPC C36_3.aPC C28_0.PA C44_7.PC C40_4.PA C32_1.aPC C40_1.PE C42_5.PA C40_8.aPC C42_6.PC C32_0.aPC ID C38_1.TG C44_4.TG C16_0.MG C44_2.DG C38_1.DG C42_0.TG C34_0.aDG C34_0.DG C40_0.TG C58_1.TG C18_1.MG C56_0.TG C56_1.TG C40_1.DG C60_2.TG C62_3.TG C54_0.TG C48_0.TG C50_0.TG C32_0.DG C40_2.TG C30_0.DG C58_2.TG C46_0.TG C26_0.FA C44_0.TG C42_0.DG C36_0.aDG C42_1.TG C46_4.TG C62_1.TG C58_0.TG C44_3.TG C44_1.DG C64_3.TG C42_2.DG C60_1.TG C40_0.DG C62_2.TG C42_2.TG C40_1.TG C42_1.DG C52_0.TG C18_2.MG C64_2.TG C22_1.FA C54_3.TG C20_2.FA C50_3.TG C48_3.TG C38_3.DG C56_4.TG C18_0.FA C24_0.FA C36_3.DG C58_5.TG C38_6.DG C54_4.TG C40_4.DG C52_6.TG C50_4.TG C50_5.TG C16_1.FA C38_5.DG C56_6.TG C16_1.MG C14_1.FA C38_2.aDG C36_1.aDG C32_1.aDG C38_0.TG C58_6.TG C24_1.FA C54_5.TG C40_5.DG C18_1.FA C22_2.FA C30_1.aDG C52_5.TG C56_5.TG C32_2.DG C52_4.TG C34_1.DG C20_1.FA C38_2.DG C58_3.TG C32_0.aDG C60_4.TG C46_2.TG C50_1.TG C56_2.TG C62_4.TG C44_1.TG C60_3.TG C30_1.DG C46_3.TG C44_2.TG C52_1.TG C62_5.TG C46_1.TG C54_1.TG C40_2.DG C48_1.TG C32_1.DG C36_1.DG C26_1.FA C52_7.TG C48_4.TG C48_2.TG C54_2.TG C52_2.TG C50_2.TG C56_3.TG C40_3.DG C14_0.FA C50_6.TG C52_3.TG C16_0.FA C34_2.DG C36_4.DG C58_4.TG C34_4.aDG C36_2.DG C18_0.MG C30_2.aDG C36_0.DG C36_3.aDG C20_3.FA C40_6.DG C38_3.aDG C38_4.DG C18_2.FA C34_3.aDG C22_4.FA C34_3.DG C54_6.TG C22_3.FA C34_1.aDG C36_4.aDG C36_2.aDG C34_2.aDG C38_4.aDG C40_7.aDG C40_6.aDG C58_7.TG C22_6.FA C18_0.FaCN C40_5.aDG C22_5.FA C54_7.TG C32_2.aDG C40_7.DG C56_7.TG C32_3.aDG C38_5.aDG C20_4.FA C38_6.aDG C16_0.FaCN C58_9.TG C56_8.TG C36_5.aDG C58_8.TG ID C40_2.PE C70_5.CL C38_3.PA C68_3.CL C30_1.aPE C36_3.aPE C38_6.PS C20_1.LPC C40_6.PS C74_9.CL C40_5.PI C40_3.PC C70_6.CL C38_2.PE C38_7.PE C36_4.aPE C32_0.PE C38_2.aPE C34_1.PE C74_7.CL C74_5.CL C30_1.PS C44_8.aPE C68_5.CL C34_0.PI C40_9.aPE C40_1.PS C42_7.PC C36_3.PE C46_7.aPE C40_2.PC C16_2.aLPC C42_5.PS C36_3.PI C36_1.PG C38_6.aPE C36_3.PA C70_7.CL C36_4.PI C42_5.PA C40_7.PC C40_5.PS C32_0.PS C38_2.PG C40_3.PG C32_2.PI C36_2.PA C40_4.PC C16_0.aLPC C42_5.aPC C32_2.PE C42_4.PS C40_6.aPC C34_1.PS C34_3.aPE C38_3.PI C34_0.PC C40_3.aPC C38_2.PC C30_1.aPC C26_1.aLPC C34_4.PE C28_0.PS C30_0.PS C40_5.aPC C40_7.PS C34_2.PE C36_2.PE C74_6.CL C32_1.PS C40_8.aPC C36_2.aPE C34_2.PI C38_1.PE C36_2.PI C40_5.PC C34_1.aPE C34_1.PG C34_4.aPE C70_4.CL C38_1.PI C40_3.aPE C30_0.PA C36_6.PE C72_4.CL C72_8.CL C44_5.PC C66_5.CL C42_1.PE C30_0.PG C32_1.PI C64_4.CL C28_1.PC C40_6.aPE C30_1.PE C28_0.PE C42_3.PE C42_5.PI C68_6.CL C40_1.aPC C66_3.CL C42_4.aPC C42_2.PE C42_6.aPE C44_6.PC C34_0.aPC C28_0.PC C64_3.CL C42_5.aPE C42_6.PS C40_4.aPE C40_5.aPE C38_6.PE C40_5.PE C38_3.aPE C46_5.aPE C46_9.aPE C72_7.CL C38_4.aPE C30_1.PI C32_1.PG C40_4.PA C42_7.aPC C36_4.PE C38_2.PI C34_1.PI C46_6.aPE C38_1.PC C44_5.aPE C36_0.PI C40_4.PE C34_1.PA C66_4.CL C40_7.aPE C18_3.aLPC C36_1.aPE C38_7.aPE C38_6.PI C40_3.PE C42_7.aPE C38_4.PE C30_0.PC C38_5.aPE C42_2.PS C42_7.PI C72_5.CL C30_0.PE C32_0.aPE C14_1.aLPC C36_5.PE C32_0.PG C40_1.PE C42_1.PS C40_8.aPE C40_6.PI C40_3.PI C44_7.PC C40_4.PI C40_7.PI C42_4.PC C46_8.aPE C42_6.PC C36_1.PI C42_6.aPC C38_0.PI C74_8.CL C30_0.aPE C38_5.PE C44_6.aPE C38_3.PE C42_8.aPE C26_0.aPC C72_6.CL C44_7.aPE C42_5.PC C68_4.CL C32_1.PE C38_1.PG C16_1.aLPC C22_0.aLPC C40_3.PA C40_2.aPC C24_0.aLPC C20_1.aLPC C40_8.PE C42_9.PE C66_2.CL C26_0.PC C40_7.PE C24_1.LPC C42_6.PE C42_4.PE C30_1.PG C26_1.LPC C42_5.PE C40_2.PI C40_6.PE C70_3.CL C42_7.PE C42_8.PE C32_0.PI C42_6.PI C32_1.PA C62_3.CL C24_0.LPC C34_0.PA C32_0.PA C30_0.PI C42_4.PI C20_0.LPC C42_4.aPE C18_1.LPA C32_2.PC C36_4.PG C40_6.PA C36_4.PC C38_4.PI C42_6.PA C38_5.PG C42_7.PA C38_5.PC C38_7.PC C36_4.aPC C34_3.PI C36_3.PG C40_7.PG C38_5.aPC C12_0.LPC C14_0.aLPC C34_3.PC C34_4.PC C36_5.aPC C38_6.aPC C40_5.PA C38_4.aPC C36_4.PS C40_6.PG C34_2.aPC C38_1.aPC C30_2.PC C36_2.aPC C34_3.PS C34_2.PG C34_2.PC C32_1.aPC C32_0.aPC C32_2.aPC C38_4.PC C38_4.PG C34_3.aPC C36_2.PG C38_6.PC C36_1.aPC C36_1.PA C36_3.aPC C36_3.PC C38_7.aPC C36_0.PE C34_2.PA C32_1.PC C32_2.PG C16_0.LPC C36_2.PC C14_0.LPC C40_5.PG C36_1.PS C34_0.PG C20_2.LPC C36_6.aPE C34_1.PC C38_5.PS C40_3.PS C40_4.aPC C38_4.PS C38_3.PG C30_2.aPC C38_5.PI C40_4.PS C38_2.PS C28_0.aPC C34_0.PE C34_2.PS C36_1.PC C40_4.PG C38_3.aPC C38_2.PA C38_3.PC C38_2.aPC C30_1.PC C38_1.PS C36_5.aPE C28_1.aPE C34_3.PE C36_3.PS C36_5.PI C30_2.aPE C36_0.PG C32_1.aPE C32_2.aPE C40_8.PC C18_0.LPC C32_0.PC C34_0.PS C38_3.PS C40_8.PI C34_2.aPE C36_1.PE C40_2.PS C36_2.PS C30_0.aPC C40_7.aPC C28_2.aPE C40_6.PC C16_0.LPA C20_0.aLPC C24_1.aLPC C20_3.LPC C20_4.LPC C18_2.aLPC C16_1.LPC C32_2.PA C38_7.PG C36_6.PC C18_2.LPC C36_5.PG C38_4.PA C18_1.aLPC C38_6.PG C36_5.PC C18_1.LPC C32_3.PC C34_3.PG ID hibition C. mTOR inhibition B. PI3k inhibition gure 4. Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. AKT, B. PI3K and C. mTOR tor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families, and lipids within family are sorted by name. 1 0.5 0 0.5 1 Neutral Lipids rol 0.3μM 3μM FA MG DG TG CL PS PI PG PA PC PE Neutral Lipids ol 0.3μM 3μM Phospholipids Control 0.3μM 3μM Phospholipids Control 0.3μM 3μM Neutral Lipids Control 0.1μM 0.3μM Phospholipids Control 0.1μM 0.3μM Neutral Lipids Control 0.1μM 0.3μM Phospholipids Control 0.1μM 0.3μM Neutral Lipids Control 0.1μM 1μM Phospholipids Control 0.1μM 1μM Phospholipids Control 0.1μM 1μM Neutral Lipids Control 0.1μM 1μM Neutral Lipids Phospholipids Fold Change C60_1.TG C54_0.TG C64_1.TG C56_3.TG C58_0.TG C62_0.TG C58_1.TG C58_3.TG C50_3.TG C64_2.TG C40_0.TG C42_0.TG C42_1.TG C44_3.TG C54_5.TG C40_1.TG C44_4.TG C46_3.TG C40_0.DG C38_0.TG C40_1.DG C42_1.DG C64_3.TG C50_4.TG C30_0.DG C50_5.TG C54_1.TG C56_1.TG C46_4.TG C50_6.TG C62_4.TG C56_5.TG C56_2.TG C48_1.TG C58_5.TG C58_8.TG C46_0.TG C62_3.TG C56_0.TG C48_2.TG C56_6.TG C50_1.TG C54_6.TG C52_1.TG C58_4.TG C52_5.TG C54_7.TG C48_0.TG C56_8.TG C36_0.aDG C58_2.TG C32_0.DG C56_4.TG C50_2.TG C52_4.TG C54_4.TG C62_5.TG C40_2.TG C58_9.TG C48_4.TG C42_3.TG C52_6.TG C42_2.TG C44_0.TG C56_7.TG C44_1.TG C48_3.TG C52_7.TG C38_1.TG C44_2.TG C58_6.TG C42_0.DG C58_7.TG C46_1.TG C46_2.TG C34_0.DG C50_0.TG C62_1.TG C54_2.TG C60_2.TG C60_4.TG C32_0.aDG C52_3.TG C60_0.TG C60_3.TG C62_2.TG C52_0.TG C34_0.aDG C52_2.TG C32_2.aDG C18_2.MG C34_1.aDG C34_2.aDG C36_0.DG C24_0.FA C38_6.DG C16_0.MG C36_3.aDG C38_1.DG C18_0.MG C36_1.aDG C18_1.MG C36_1.DG C54_3.TG C32_1.aDG C34_3.aDG C30_1.aDG C36_4.aDG C22_2.FA C22_1.FA C40_3.DG C44_1.DG C20_2.FA C20_3.FA C22_3.FA C20_4.FA C34_4.aDG C42_2.DG C18_0.FaCN C20_1.FA C40_7.aDG C22_4.FA C44_2.DG C40_6.DG C30_2.aDG C22_6.FA C40_5.DG C18_0.FA C38_5.DG C22_5.FA C40_2.DG C18_1.FA C26_1.FA C30_1.DG C38_2.DG C32_3.aDG C36_2.DG C18_2.FA C24_1.FA C38_3.DG C38_4.DG C14_1.FA C16_0.FA C32_2.DG C32_1.DG C36_2.aDG C34_1.DG C40_7.DG C26_0.FA C38_6.aDG C38_4.aDG C38_5.aDG C38_3.aDG C36_3.DG C14_0.FA C16_0.FaCN C16_1.FA C34_2.DG C16_1.MG C34_3.DG C40_6.aDG C36_5.aDG C40_4.DG C38_2.aDG C40_5.aDG ID C36_0.PI C14_1.aLPC C16_0.LPA C40_0.PS C38_0.PI C30_1.PA C18_0.LPA C40_3.PA C40_4.PA C34_0.PA C28_0.PA C30_0.PA C32_0.PA C26_0.PC C26_0.PA C32_2.PA C16_2.aLPC C40_5.PE C28_1.PA C36_0.PA C16_0.aLPC C44_6.aPE C40_1.PE C42_1.PE C42_4.PC C36_4.aPC C36_5.aPC C40_3.aPC C28_0.PC C42_6.PC C20_0.LPC C32_0.PI C18_0.LPC C40_4.aPC C36_1.aPE C44_6.PC C36_6.PE C30_0.PI C30_2.aPC C34_1.PA C34_2.PA C38_7.aPC C36_3.PA C44_7.PC C32_1.PA C42_5.PA C36_0.PE C34_0.PC C42_6.PS C20_2.LPC C20_3.LPC C42_9.PE C42_7.PI C14_0.LPC C30_1.PS C20_4.LPC C34_3.PS C38_4.PA C40_8.PI C16_1.LPC C18_3.aLPC C28_1.PE C62_3.CL C42_7.PE C34_4.PC C74_8.CL C18_1.LPC C18_2.LPC C36_4.PS C28_0.PE C40_3.PG C40_4.PG C38_7.PG C38_5.PS C70_5.CL C40_8.PC C40_9.aPE C38_7.PC C40_5.PG C40_9.PI C72_6.CL C34_4.PE C40_7.PG C42_8.PE C40_6.PG C42_6.PA C74_7.CL C30_0.PE C38_3.PS C42_8.aPE C72_7.CL C44_7.aPE C40_7.PE C66_5.CL C32_1.PE C70_3.CL C42_4.PI C74_6.CL C30_2.PC C70_6.CL C20_1.LPC C28_0.LPC C38_6.PG C72_8.CL C42_5.aPE C40_9.PE C72_5.CL C34_1.PE C68_5.CL C30_1.PE C74_9.CL C16_1.aLPC C38_6.PS C70_7.CL C42_6.PE C66_4.CL C38_2.PS C38_1.PG C38_4.PG C40_6.PA C38_5.PG C32_2.PE C34_2.PS C36_5.PI C68_6.CL C38_2.PG C36_1.PS C32_2.PI C40_6.PS C40_7.PS C38_3.PG C70_4.CL C36_2.PA C68_4.CL C34_3.PI C38_4.PS C66_2.CL C34_1.PS C40_4.PS C34_3.PC C36_2.PS C42_6.aPC C12_0.LPC C42_2.PS C66_3.CL C32_0.PE C34_1.PG C36_4.PG C32_1.PS C18_1.aLPC C30_2.aPE C36_4.PI C64_4.CL C34_2.PE C16_0.LPC C42_4.PE C36_6.aPE C38_4.aPC C24_0.aLPC C36_3.aPC C38_3.aPE C30_1.aPC C36_4.aPE C18_1.LPA C38_6.aPC C38_5.aPC C40_5.PA C38_2.aPC C28_1.PC C40_4.PE C38_2.aPE C40_3.PE C38_6.PE C38_4.PE C38_4.aPE C36_2.aPC C68_3.CL C36_6.aPC C42_2.PE C42_5.PI C30_0.PC C42_4.aPC C38_1.aPC C40_7.aPC C34_1.aPE C40_8.aPC C42_6.PI C40_6.aPC C74_5.CL C20_1.aLPC C38_3.aPC C40_5.aPC C40_3.PC C38_3.PE C38_3.PA C40_6.PC C42_3.PE C40_5.PC C38_5.PE C42_5.PS C42_5.PC C32_1.aPC C40_7.PI C36_4.PE C34_0.PI C38_4.PC C38_1.PE C38_1.PC C38_6.PC C22_0.aLPC C30_0.PG C38_2.PE C42_5.PE C26_0.aPC C40_1.aPC C44_5.PC C30_0.aPC C40_2.PC C34_1.aPC C40_2.PE C40_4.PC C36_2.aPE C32_2.aPC C34_2.aPC C40_5.PI C40_4.PI C34_0.PS C40_6.PI C42_7.PC C36_5.aPE C36_5.PE C32_0.PC C38_3.PC C36_1.aPC C36_3.aPE C30_1.PC C32_2.aPE C36_3.PE C40_8.PE C36_6.PC C38_3.PI C40_2.PS C32_1.PI C36_3.PI C24_0.LPC C30_0.aPE C42_7.aPC C36_2.PI C34_0.aPC C36_1.PG C34_2.PC C40_2.aPC C26_1.LPC C40_1.PS C28_1.aPE C42_7.aPE C24_1.LPC C42_4.aPE C34_1.PI C34_1.PC C34_3.PE C34_2.PI C34_3.PG C32_1.PC C34_2.PG C40_7.PC C36_2.PE C40_3.PS C36_3.PG C32_2.PG C36_3.PS C34_0.PG C40_6.aPE C32_2.PC C40_7.aPE C28_2.aPE C38_2.PI C42_6.aPE C38_1.PS C40_8.aPE C40_5.PS C36_2.PG C30_1.PI C36_5.PG C20_0.aLPC C36_0.PG C72_4.CL C34_3.aPC C42_4.PS C32_0.aPC C40_3.aPE C40_3.PI C34_4.aPE C38_5.PC C28_0.aPC C38_7.PE C32_0.PG C38_5.aPE C38_2.PA C32_0.aPE C38_5.PI C32_0.PS C14_0.aLPC C64_3.CL C30_1.PG C42_5.aPC C36_1.PI C34_2.aPE C38_6.aPE C36_5.PC C36_1.PC C32_1.aPE C44_8.aPE C40_2.PI C36_3.PC C38_2.PC C22_2.aLPC C38_7.aPE C40_5.aPE C30_0.PS C34_3.aPE C36_1.PA C38_6.PI C36_4.PC C42_7.PA C32_3.PC C32_1.PG C28_0.PS C38_1.PI C44_5.aPE C42_1.PS C38_4.PI C34_0.PE C36_1.PE C40_6.PE C40_4.aPE C30_1.aPE C36_2.PC C18_2.aLPC ID C38_1.TG C30_2.aDG C38_3.aDG C40_5.aDG C18_0.FaCN C32_1.aDG C36_5.aDG C18_0.FA C38_5.aDG C38_4.aDG C40_7.aDG C32_2.aDG C14_1.FA C38_6.aDG C16_0.FA C34_2.DG C34_3.DG C30_1.DG C38_4.DG C40_6.aDG C32_1.DG C32_0.aDG C32_2.DG C36_2.aDG C14_0.FA C16_1.FA C36_4.DG C38_0.TG C34_3.aDG C36_4.aDG C30_1.aDG C34_1.aDG C34_2.aDG C36_3.aDG C18_1.FA C36_1.aDG C16_0.FaCN C18_2.FA C38_2.aDG C40_2.TG C32_3.aDG C38_3.DG C24_1.FA C36_0.aDG C38_2.DG C40_3.DG C16_0.MG C36_1.DG C34_0.aDG C20_4.FA C18_0.MG C26_0.FA C32_0.DG C36_2.DG C18_2.MG C42_3.TG C34_1.DG C38_5.DG C16_1.MG C24_0.FA C36_3.DG C34_4.aDG C30_0.DG C56_8.TG C52_5.TG C54_7.TG C56_7.TG C58_7.TG C58_8.TG C48_3.TG C50_4.TG C52_7.TG C56_4.TG C52_4.TG C54_5.TG C56_5.TG C58_6.TG C50_5.TG C58_5.TG C20_2.FA C56_6.TG C58_4.TG C54_6.TG C50_3.TG C52_6.TG C50_6.TG C58_9.TG C20_1.FA C62_0.TG C22_5.FA C38_6.DG C40_1.DG C38_1.DG C40_2.DG C26_1.FA C36_0.DG C40_1.TG C40_0.DG C52_0.TG C40_5.DG C22_4.FA C42_0.DG C22_2.FA C42_1.DG C20_3.FA C58_0.TG C40_4.DG C44_4.TG C42_2.DG C42_0.TG C48_0.TG C60_0.TG C40_0.TG C56_0.TG C50_0.TG C44_1.DG C34_0.DG C42_1.TG C44_2.DG C60_2.TG C56_1.TG C60_1.TG C22_1.FA C46_0.TG C44_1.TG C58_1.TG C40_6.DG C46_3.TG C52_1.TG C62_1.TG C62_5.TG C62_3.TG C22_6.FA C44_3.TG C62_2.TG C54_1.TG C62_4.TG C50_1.TG C48_1.TG C58_2.TG C42_2.TG C44_0.TG C46_1.TG C60_4.TG C54_0.TG C52_3.TG C64_1.TG C54_2.TG C52_2.TG C56_2.TG C60_3.TG C58_3.TG C48_4.TG C56_3.TG C46_2.TG C50_2.TG C46_4.TG C18_1.MG C64_2.TG C40_7.DG C64_3.TG C44_2.TG C54_4.TG C22_3.FA C48_2.TG C54_3.TG ID C28_1.PA C30_2.aPC C36_0.aPC C72_4.CL C44_8.aPE C46_9.aPE C46_8.aPE C36_5.aPC C40_9.PI C38_7.aPC C40_8.aPC C28_1.PE C42_7.aPC C40_6.aPE C30_1.aPC C42_1.PE C36_6.aPC C36_1.aPE C40_8.PI C38_0.PI C42_7.PC 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C56_3.TG C40_3.DG C14_0.FA C50_6.TG C52_3.TG C16_0.FA C34_2.DG C36_4.DG C58_4.TG C34_4.aDG C36_2.DG C18_0.MG C30_2.aDG C36_0.DG C36_3.aDG C20_3.FA C40_6.DG C38_3.aDG C38_4.DG C18_2.FA C34_3.aDG C22_4.FA C34_3.DG C54_6.TG C22_3.FA C34_1.aDG C36_4.aDG C36_2.aDG C34_2.aDG C38_4.aDG C40_7.aDG C40_6.aDG C58_7.TG C22_6.FA C18_0.FaCN C40_5.aDG C22_5.FA C54_7.TG C32_2.aDG C40_7.DG C56_7.TG C32_3.aDG C38_5.aDG C20_4.FA C38_6.aDG C16_0.FaCN C58_9.TG C56_8.TG C36_5.aDG C58_8.TG ID C40_2.PE C70_5.CL C38_3.PA C68_3.CL C30_1.aPE C36_3.aPE C38_6.PS C20_1.LPC C40_6.PS C74_9.CL C40_5.PI C40_3.PC C70_6.CL C38_2.PE C38_7.PE C36_4.aPE C32_0.PE C38_2.aPE C34_1.PE C74_7.CL C74_5.CL C30_1.PS C44_8.aPE C68_5.CL C34_0.PI C40_9.aPE C40_1.PS C42_7.PC C36_3.PE C46_7.aPE C40_2.PC C16_2.aLPC C42_5.PS C36_3.PI C36_1.PG C38_6.aPE C36_3.PA C70_7.CL C36_4.PI C42_5.PA C40_7.PC C40_5.PS C32_0.PS C38_2.PG C40_3.PG C32_2.PI C36_2.PA C40_4.PC C16_0.aLPC C42_5.aPC C32_2.PE C42_4.PS C40_6.aPC C34_1.PS C34_3.aPE C38_3.PI C34_0.PC C40_3.aPC C38_2.PC C30_1.aPC C26_1.aLPC C34_4.PE C28_0.PS C30_0.PS C40_5.aPC C40_7.PS C34_2.PE C36_2.PE C74_6.CL C32_1.PS C40_8.aPC C36_2.aPE C34_2.PI C38_1.PE C36_2.PI C40_5.PC C34_1.aPE C34_1.PG C34_4.aPE C70_4.CL C38_1.PI C40_3.aPE C30_0.PA C36_6.PE C72_4.CL C72_8.CL C44_5.PC C66_5.CL C42_1.PE C30_0.PG C32_1.PI C64_4.CL C28_1.PC C40_6.aPE C30_1.PE C28_0.PE C42_3.PE C42_5.PI C68_6.CL C40_1.aPC C66_3.CL C42_4.aPC C42_2.PE C42_6.aPE C44_6.PC C34_0.aPC C28_0.PC C64_3.CL C42_5.aPE C42_6.PS C40_4.aPE C40_5.aPE C38_6.PE C40_5.PE C38_3.aPE C46_5.aPE C46_9.aPE C72_7.CL C38_4.aPE C30_1.PI C32_1.PG C40_4.PA C42_7.aPC C36_4.PE C38_2.PI C34_1.PI C46_6.aPE C38_1.PC C44_5.aPE C36_0.PI C40_4.PE C34_1.PA C66_4.CL C40_7.aPE C18_3.aLPC C36_1.aPE C38_7.aPE C38_6.PI C40_3.PE C42_7.aPE C38_4.PE C30_0.PC C38_5.aPE C42_2.PS C42_7.PI C72_5.CL C30_0.PE C32_0.aPE C14_1.aLPC C36_5.PE C32_0.PG C40_1.PE C42_1.PS C40_8.aPE C40_6.PI C40_3.PI C44_7.PC C40_4.PI C40_7.PI C42_4.PC C46_8.aPE C42_6.PC C36_1.PI C42_6.aPC C38_0.PI C74_8.CL C30_0.aPE C38_5.PE C44_6.aPE C38_3.PE C42_8.aPE C26_0.aPC C72_6.CL C44_7.aPE C42_5.PC C68_4.CL C32_1.PE C38_1.PG C16_1.aLPC C22_0.aLPC C40_3.PA C40_2.aPC C24_0.aLPC C20_1.aLPC C40_8.PE C42_9.PE C66_2.CL C26_0.PC C40_7.PE C24_1.LPC C42_6.PE C42_4.PE C30_1.PG C26_1.LPC C42_5.PE C40_2.PI C40_6.PE C70_3.CL C42_7.PE C42_8.PE C32_0.PI C42_6.PI C32_1.PA C62_3.CL C24_0.LPC C34_0.PA C32_0.PA C30_0.PI C42_4.PI C20_0.LPC C42_4.aPE C18_1.LPA C32_2.PC C36_4.PG C40_6.PA C36_4.PC C38_4.PI C42_6.PA C38_5.PG C42_7.PA C38_5.PC C38_7.PC C36_4.aPC C34_3.PI C36_3.PG C40_7.PG C38_5.aPC C12_0.LPC C14_0.aLPC C34_3.PC C34_4.PC C36_5.aPC C38_6.aPC C40_5.PA C38_4.aPC C36_4.PS C40_6.PG C34_2.aPC C38_1.aPC C30_2.PC C36_2.aPC C34_3.PS C34_2.PG C34_2.PC C32_1.aPC C32_0.aPC C32_2.aPC C38_4.PC C38_4.PG C34_3.aPC C36_2.PG C38_6.PC C36_1.aPC C36_1.PA C36_3.aPC C36_3.PC C38_7.aPC C36_0.PE C34_2.PA C32_1.PC C32_2.PG C16_0.LPC C36_2.PC C14_0.LPC C40_5.PG C36_1.PS C34_0.PG C20_2.LPC C36_6.aPE C34_1.PC C38_5.PS C40_3.PS C40_4.aPC C38_4.PS C38_3.PG C30_2.aPC C38_5.PI C40_4.PS C38_2.PS C28_0.aPC C34_0.PE C34_2.PS C36_1.PC C40_4.PG C38_3.aPC C38_2.PA C38_3.PC C38_2.aPC C30_1.PC C38_1.PS C36_5.aPE C28_1.aPE C34_3.PE C36_3.PS C36_5.PI C30_2.aPE C36_0.PG C32_1.aPE C32_2.aPE C40_8.PC C18_0.LPC C32_0.PC C34_0.PS C38_3.PS C40_8.PI C34_2.aPE C36_1.PE C40_2.PS C36_2.PS C30_0.aPC C40_7.aPC C28_2.aPE C40_6.PC C16_0.LPA C20_0.aLPC C24_1.aLPC C20_3.LPC C20_4.LPC C18_2.aLPC C16_1.LPC C32_2.PA C38_7.PG C36_6.PC C18_2.LPC C36_5.PG C38_4.PA C18_1.aLPC C38_6.PG C36_5.PC C18_1.LPC C32_3.PC C34_3.PG ID hibition C. C60_1.TG C54_0.TG C64_1.TG C56_3.TG C58_0.TG C62_0.TG C58_1.TG C58_3.TG C50_3.TG C64_2.TG C40_0.TG C42_0.TG C42_1.TG C44_3.TG C54_5.TG C40_1.TG C44_4.TG C46_3.TG C40_0.DG C38_0.TG C40_1.DG C42_1.DG C64_3.TG C50_4.TG C30_0.DG C50_5.TG C54_1.TG C56_1.TG C46_4.TG C50_6.TG C62_4.TG C56_5.TG C56_2.TG C48_1.TG C58_5.TG C58_8.TG C46_0.TG C62_3.TG C56_0.TG C48_2.TG C56_6.TG C50_1.TG C54_6.TG C52_1.TG C58_4.TG C52_5.TG C54_7.TG C48_0.TG C56_8.TG C36_0.aDG C58_2.TG C32_0.DG C56_4.TG C50_2.TG C52_4.TG C54_4.TG C62_5.TG C40_2.TG C58_9.TG C48_4.TG C42_3.TG C52_6.TG C42_2.TG C44_0.TG C56_7.TG C44_1.TG C48_3.TG C52_7.TG C38_1.TG C44_2.TG C58_6.TG C42_0.DG C58_7.TG C46_1.TG C46_2.TG C34_0.DG C50_0.TG C62_1.TG C54_2.TG C60_2.TG C60_4.TG C32_0.aDG C52_3.TG C60_0.TG C60_3.TG C62_2.TG C52_0.TG C34_0.aDG C52_2.TG C32_2.aDG C18_2.MG C34_1.aDG C34_2.aDG C36_0.DG C24_0.FA C38_6.DG C16_0.MG C36_3.aDG C38_1.DG C18_0.MG C36_1.aDG C18_1.MG C36_1.DG C54_3.TG C32_1.aDG C34_3.aDG C30_1.aDG C36_4.aDG C22_2.FA C22_1.FA C40_3.DG C44_1.DG C20_2.FA C20_3.FA C22_3.FA C20_4.FA C34_4.aDG C42_2.DG C18_0.FaCN C20_1.FA C40_7.aDG C22_4.FA C44_2.DG C40_6.DG C30_2.aDG C22_6.FA C40_5.DG C18_0.FA C38_5.DG C22_5.FA C40_2.DG C18_1.FA C26_1.FA C30_1.DG C38_2.DG C32_3.aDG C36_2.DG C18_2.FA C24_1.FA C38_3.DG C38_4.DG C14_1.FA C16_0.FA C32_2.DG C32_1.DG C36_2.aDG C34_1.DG C40_7.DG C26_0.FA C38_6.aDG C38_4.aDG C38_5.aDG C38_3.aDG C36_3.DG C14_0.FA C16_0.FaCN C16_1.FA C34_2.DG C16_1.MG C34_3.DG C40_6.aDG C36_5.aDG C40_4.DG C38_2.aDG C40_5.aDG ID C36_0.PI C14_1.aLPC C16_0.LPA C40_0.PS C38_0.PI C30_1.PA C18_0.LPA C40_3.PA C40_4.PA C34_0.PA C28_0.PA C30_0.PA C32_0.PA C26_0.PC C26_0.PA C32_2.PA C16_2.aLPC C40_5.PE C28_1.PA C36_0.PA C16_0.aLPC C44_6.aPE C40_1.PE C42_1.PE C42_4.PC C36_4.aPC C36_5.aPC C40_3.aPC C28_0.PC C42_6.PC C20_0.LPC C32_0.PI C18_0.LPC C40_4.aPC C36_1.aPE C44_6.PC C36_6.PE C30_0.PI C30_2.aPC C34_1.PA C34_2.PA C38_7.aPC C36_3.PA C44_7.PC C32_1.PA C42_5.PA C36_0.PE C34_0.PC C42_6.PS C20_2.LPC C20_3.LPC C42_9.PE C42_7.PI C14_0.LPC C30_1.PS C20_4.LPC C34_3.PS C38_4.PA C40_8.PI C16_1.LPC C18_3.aLPC C28_1.PE C62_3.CL C42_7.PE C34_4.PC C74_8.CL C18_1.LPC C18_2.LPC C36_4.PS C28_0.PE C40_3.PG C40_4.PG C38_7.PG C38_5.PS C70_5.CL C40_8.PC C40_9.aPE C38_7.PC C40_5.PG C40_9.PI C72_6.CL C34_4.PE C40_7.PG C42_8.PE C40_6.PG C42_6.PA C74_7.CL C30_0.PE C38_3.PS C42_8.aPE C72_7.CL C44_7.aPE C40_7.PE C66_5.CL C32_1.PE C70_3.CL C42_4.PI C74_6.CL C30_2.PC C70_6.CL C20_1.LPC C28_0.LPC C38_6.PG C72_8.CL C42_5.aPE C40_9.PE C72_5.CL C34_1.PE C68_5.CL C30_1.PE C74_9.CL C16_1.aLPC C38_6.PS C70_7.CL C42_6.PE C66_4.CL C38_2.PS C38_1.PG C38_4.PG C40_6.PA C38_5.PG C32_2.PE C34_2.PS C36_5.PI C68_6.CL C38_2.PG C36_1.PS C32_2.PI C40_6.PS C40_7.PS C38_3.PG C70_4.CL C36_2.PA C68_4.CL C34_3.PI C38_4.PS C66_2.CL C34_1.PS C40_4.PS C34_3.PC C36_2.PS C42_6.aPC C12_0.LPC C42_2.PS C66_3.CL C32_0.PE C34_1.PG C36_4.PG C32_1.PS C18_1.aLPC C30_2.aPE C36_4.PI C64_4.CL C34_2.PE C16_0.LPC C42_4.PE C36_6.aPE C38_4.aPC C24_0.aLPC C36_3.aPC C38_3.aPE C30_1.aPC C36_4.aPE C18_1.LPA C38_6.aPC C38_5.aPC C40_5.PA C38_2.aPC C28_1.PC C40_4.PE C38_2.aPE C40_3.PE C38_6.PE C38_4.PE C38_4.aPE C36_2.aPC C68_3.CL C36_6.aPC C42_2.PE C42_5.PI C30_0.PC C42_4.aPC C38_1.aPC C40_7.aPC C34_1.aPE C40_8.aPC C42_6.PI C40_6.aPC C74_5.CL C20_1.aLPC C38_3.aPC C40_5.aPC C40_3.PC C38_3.PE C38_3.PA C40_6.PC C42_3.PE C40_5.PC C38_5.PE C42_5.PS C42_5.PC C32_1.aPC C40_7.PI C36_4.PE C34_0.PI C38_4.PC C38_1.PE C38_1.PC C38_6.PC C22_0.aLPC C30_0.PG C38_2.PE C42_5.PE C26_0.aPC C40_1.aPC C44_5.PC C30_0.aPC C40_2.PC C34_1.aPC C40_2.PE C40_4.PC C36_2.aPE C32_2.aPC C34_2.aPC C40_5.PI C40_4.PI C34_0.PS C40_6.PI C42_7.PC C36_5.aPE C36_5.PE C32_0.PC C38_3.PC C36_1.aPC C36_3.aPE C30_1.PC C32_2.aPE C36_3.PE C40_8.PE C36_6.PC C38_3.PI C40_2.PS C32_1.PI C36_3.PI C24_0.LPC C30_0.aPE C42_7.aPC C36_2.PI C34_0.aPC C36_1.PG C34_2.PC C40_2.aPC C26_1.LPC C40_1.PS C28_1.aPE C42_7.aPE C24_1.LPC C42_4.aPE C34_1.PI C34_1.PC C34_3.PE C34_2.PI C34_3.PG C32_1.PC C34_2.PG C40_7.PC C36_2.PE C40_3.PS C36_3.PG C32_2.PG C36_3.PS C34_0.PG C40_6.aPE C32_2.PC C40_7.aPE C28_2.aPE C38_2.PI C42_6.aPE C38_1.PS C40_8.aPE C40_5.PS C36_2.PG C30_1.PI C36_5.PG C20_0.aLPC C36_0.PG C72_4.CL C34_3.aPC C42_4.PS C32_0.aPC C40_3.aPE C40_3.PI C34_4.aPE C38_5.PC C28_0.aPC C38_7.PE C32_0.PG C38_5.aPE C38_2.PA C32_0.aPE C38_5.PI C32_0.PS C14_0.aLPC C64_3.CL C30_1.PG C42_5.aPC C36_1.PI C34_2.aPE C38_6.aPE C36_5.PC C36_1.PC C32_1.aPE C44_8.aPE C40_2.PI C36_3.PC C38_2.PC C22_2.aLPC C38_7.aPE C40_5.aPE C30_0.PS C34_3.aPE C36_1.PA C38_6.PI C36_4.PC C42_7.PA C32_3.PC C32_1.PG C28_0.PS C38_1.PI C44_5.aPE C42_1.PS C38_4.PI C34_0.PE C36_1.PE C40_6.PE C40_4.aPE C30_1.aPE C36_2.PC C18_2.aLPC ID C38_1.TG C30_2.aDG C38_3.aDG C40_5.aDG C18_0.FaCN C32_1.aDG C36_5.aDG C18_0.FA C38_5.aDG C38_4.aDG C40_7.aDG C32_2.aDG C14_1.FA C38_6.aDG C16_0.FA C34_2.DG C34_3.DG C30_1.DG C38_4.DG C40_6.aDG C32_1.DG C32_0.aDG C32_2.DG C36_2.aDG C14_0.FA C16_1.FA C36_4.DG C38_0.TG C34_3.aDG C36_4.aDG C30_1.aDG C34_1.aDG C34_2.aDG C36_3.aDG C18_1.FA C36_1.aDG C16_0.FaCN C18_2.FA C38_2.aDG C40_2.TG C32_3.aDG C38_3.DG C24_1.FA C36_0.aDG C38_2.DG C40_3.DG C16_0.MG C36_1.DG C34_0.aDG C20_4.FA C18_0.MG C26_0.FA C32_0.DG C36_2.DG C18_2.MG C42_3.TG C34_1.DG C38_5.DG C16_1.MG C24_0.FA C36_3.DG C34_4.aDG C30_0.DG C56_8.TG C52_5.TG C54_7.TG C56_7.TG C58_7.TG C58_8.TG C48_3.TG C50_4.TG C52_7.TG C56_4.TG C52_4.TG C54_5.TG C56_5.TG C58_6.TG C50_5.TG C58_5.TG C20_2.FA C56_6.TG C58_4.TG C54_6.TG C50_3.TG C52_6.TG C50_6.TG C58_9.TG C20_1.FA C62_0.TG C22_5.FA C38_6.DG C40_1.DG C38_1.DG C40_2.DG C26_1.FA C36_0.DG C40_1.TG C40_0.DG C52_0.TG C40_5.DG C22_4.FA C42_0.DG C22_2.FA C42_1.DG C20_3.FA C58_0.TG C40_4.DG C44_4.TG C42_2.DG C42_0.TG C48_0.TG C60_0.TG C40_0.TG C56_0.TG C50_0.TG C44_1.DG C34_0.DG C42_1.TG C44_2.DG C60_2.TG C56_1.TG C60_1.TG C22_1.FA C46_0.TG C44_1.TG C58_1.TG C40_6.DG C46_3.TG C52_1.TG C62_1.TG C62_5.TG C62_3.TG C22_6.FA C44_3.TG C62_2.TG C54_1.TG C62_4.TG C50_1.TG C48_1.TG C58_2.TG C42_2.TG C44_0.TG C46_1.TG C60_4.TG C54_0.TG C52_3.TG C64_1.TG C54_2.TG C52_2.TG C56_2.TG C60_3.TG C58_3.TG C48_4.TG C56_3.TG C46_2.TG C50_2.TG C46_4.TG C18_1.MG C64_2.TG C40_7.DG C64_3.TG C44_2.TG C54_4.TG C22_3.FA C48_2.TG C54_3.TG ID C28_1.PA C30_2.aPC C36_0.aPC C72_4.CL C44_8.aPE C46_9.aPE C46_8.aPE C36_5.aPC C40_9.PI C38_7.aPC C40_8.aPC C28_1.PE C42_7.aPC C40_6.aPE C30_1.aPC C42_1.PE C36_6.aPC C36_1.aPE C40_8.PI C38_0.PI C42_7.PC C40_5.aPE C18_0.LPC C14_1.aLPC C16_1.aLPC C38_6.aPC C40_3.aPE C18_2.aLPC C36_1.PC C38_6.PC C70_3.CL C42_4.PC C26_0.PC C70_4.CL C40_8.PC C40_6.PE C74_8.CL C40_1.PE C40_5.aPC C40_3.PC C42_5.PS C40_7.PC C46_5.aPE C40_2.PC C40_7.aPC C44_5.PC C40_6.PC C38_6.aPE C40_4.PI C40_6.PI C26_0.aPC C40_5.PC C42_6.aPC C40_3.PE C40_5.PI C38_1.PG C42_6.PE C42_8.PE C42_5.PI C42_5.PC C40_4.PE C38_4.aPE C44_7.PC C40_1.aPC C16_2.aLPC C42_6.PC C72_7.CL C40_6.aPC C40_4.PC C40_3.PI C38_2.PC C36_4.aPE C38_3.aPE C40_4.aPE C40_6.PS C42_6.PI C42_7.aPE C46_7.aPE C44_7.aPE C46_6.aPE C42_6.aPE C44_6.aPE C36_0.PA C72_5.CL C22_1.aLPC C42_5.aPE C74_7.CL C42_8.aPE C44_5.aPE C74_5.CL C20_1.aLPC C40_9.PE C38_1.PC C42_6.PS C72_6.CL C38_5.aPE C40_7.aPE C42_4.aPE C40_8.aPE C28_0.LPC C38_7.aPE C36_5.aPE C40_9.aPE C12_0.LPC C40_5.PA C32_1.PA C34_1.PA C40_0.PS C20_4.LPC C40_6.PA C42_6.PA C32_2.PA C38_4.PA C34_3.aPC C36_4.aPC C40_3.aPC C36_6.PC C42_4.aPC C42_3.PE C34_0.PC C38_1.aPC C38_6.PE C38_2.aPC C40_2.aPC C20_1.LPC C70_5.CL C38_3.PC C36_6.aPE C42_7.PE C42_2.PE C44_6.PC C28_0.PE C66_3.CL C38_7.PC C40_5.PE C38_2.aPE C36_1.aPC C40_2.PE C42_9.PE C40_5.PS C42_1.PS C74_9.CL C36_1.PG C38_3.aPC C42_4.PI C24_0.LPC C38_3.PA C70_6.CL C20_2.LPC C38_2.PE C36_3.aPE C40_7.PI C42_5.aPC C42_4.PE C42_2.PS C18_1.aLPC C74_6.CL C38_1.PE C42_7.PI C28_0.PC C38_5.aPC C38_4.aPC C72_8.CL C42_5.PE C40_4.aPC C34_0.PI C20_0.LPC C34_1.PG C38_6.PI C38_3.PI C34_0.aPC C34_0.PA C38_3.PE C38_4.PI C38_4.PE C38_1.PI C34_1.PC C40_2.PI C26_1.LPC C30_0.PC C36_2.aPC C36_4.PI C36_3.aPC 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C32_2.aPE C36_5.aPE C36_1.PS C40_6.PI C40_6.PA C36_2.PS C70_7.CL C34_2.aPC C34_2.aPE C38_6.aPC C38_5.PI C36_5.aPC C38_7.PE C36_3.PS C34_2.PA C30_2.PC C34_3.aPE C32_2.aPC C34_3.aPC C36_2.PA C32_2.PE C68_6.CL C74_6.CL C38_1.PS C34_2.PI C42_4.PS C34_3.PI C36_3.PA C34_2.PS C32_1.PA C34_3.PS C32_2.PA C36_4.PI C34_4.aPE C38_4.PA C36_5.PI C40_3.PS C36_6.aPE C18_1.LPA C38_4.PI C32_2.PC C34_3.PC C34_3.PG C32_3.PC C34_3.PE C36_4.PS C34_4.PC C36_1.PA C36_0.PE C74_9.CL C34_1.PA C36_3.PC C36_3.PG C38_7.PC C32_1.aPC C36_5.PG C34_2.PC C36_5.PC C14_0.aLPC C38_4.PS C36_4.PC C38_5.PC C32_1.PC C36_4.PG C38_5.PG C34_1.PC C38_4.PC C38_6.PC C36_2.PC C38_5.aPC C34_2.PG C20_3.LPC C12_0.LPC C18_1.LPC C16_1.LPC C34_0.PG C20_4.LPC C38_6.PG C18_2.LPC C38_4.PG C32_0.PC C40_5.PI C36_0.PI C36_2.aPC C42_5.PA C34_1.PG C38_5.PS C72_4.CL C36_4.aPC C72_8.CL C38_3.PC C18_0.LPC C16_0.LPA C32_1.aPE C36_1.PC C36_3.aPC C32_2.PG C28_1.aPE C38_6.aPE C34_1.PS C40_8.PE C36_3.PI C70_6.CL C40_8.aPC C40_7.PE C40_8.aPE C68_5.CL C32_2.PI C42_9.PE C72_7.CL C40_4.PS C36_2.PI C40_8.PI C38_7.aPC C38_3.PI C38_3.PS C30_2.aPC C38_2.PA C40_9.aPE C40_7.PI C40_5.PA C38_3.PA C40_7.PS C40_4.PA C38_6.PI C42_8.PE C30_1.aPE C74_8.CL C38_7.aPE C38_5.aPE C32_1.PS C70_5.CL C68_4.CL C70_4.CL C30_1.aPC C66_4.CL C66_5.CL C40_7.aPE C32_1.PI C30_1.PC C44_6.aPE C44_7.aPE C40_5.PS C68_3.CL C42_5.PE C34_4.PE C38_0.PI C42_6.aPE C40_6.aPE C42_5.aPE C42_7.aPE C42_8.aPE C30_1.PI C44_5.aPE C66_3.CL C14_1.aLPC C42_2.PS C46_6.aPE C72_6.CL C44_8.aPE C46_7.aPE C42_7.PE C46_9.aPE C28_0.aPC C38_3.aPC C30_0.aPC C40_5.PC C36_0.PG C40_2.aPC C40_4.PC C16_0.aLPC C38_6.PE C40_7.PC C34_0.aPC C20_0.aLPC C16_1.aLPC C40_5.PG C38_4.PE C38_3.PG C34_1.PE C36_2.aPE C42_5.aPC C32_0.PG C40_3.PC C38_2.PE C38_1.PE C40_4.PG C40_5.aPC C20_1.LPC C38_2.PC C40_6.aPC C32_0.PS C38_3.PE C28_0.PA C40_1.PE C34_0.PA C40_3.PG C38_1.PC C32_0.PA C40_7.aPC C42_5.PC C28_0.PS C30_0.PS C36_4.PE C66_2.CL C40_2.PE C42_1.PE C42_6.PC C38_5.PE C36_1.PG C74_7.CL C40_3.aPC C34_1.aPE C42_7.PC C16_2.aLPC C30_0.PA C36_6.PE C40_3.aPE C40_5.PE C40_6.PE C30_1.PE C30_0.PG C34_0.PI C28_1.PC C34_0.PS C40_6.PS C38_4.aPE C64_3.CL C32_1.PG C42_7.aPC C42_7.PI C40_4.aPE C24_1.aLPC C34_1.PI C38_2.PI C20_0.LPC C42_6.PE C72_5.CL C42_4.PE C38_1.PG C62_3.CL C40_5.aPE C42_4.aPE C42_3.PE C40_2.PC C42_4.PC C36_4.aPE C32_1.PE C36_1.aPE C32_0.PE C26_0.aPC C26_0.PC C30_0.aPE C40_3.PI C44_7.PC C42_6.aPC C44_5.PC C42_2.PE C36_1.PI C30_0.PC C42_5.PI C20_1.aLPC C70_3.CL C40_1.PS C38_2.aPE C42_6.PI C38_6.PS C28_0.PE C42_1.PS C38_1.PI C64_4.CL C28_0.PC C30_0.PE C36_3.aPE C40_2.PI C40_3.PE C38_2.PG C24_1.LPC C24_0.aLPC C42_5.PS C40_4.PE C32_0.PI C42_6.PS C44_6.PC C46_5.aPE C30_0.PI C40_4.PI C42_4.PI C26_1.LPC C40_3.PA C32_0.aPE C38_3.aPE ID C32_0.DG C40_0.DG C36_3.aDG C36_4.aDG C36_1.aDG C32_0.aDG C34_0.DG C42_0.DG C32_1.aDG C34_0.aDG C46_2.TG C42_2.TG C44_1.TG C40_1.TG C40_0.TG C42_1.TG C42_0.TG C44_2.TG C46_3.TG C30_0.DG C44_4.TG C46_4.TG C38_0.TG C38_1.TG C50_5.TG C36_0.aDG C44_3.TG C50_4.TG C34_1.DG C42_1.DG C18_1.MG C36_1.DG C40_1.DG C50_6.TG C34_1.aDG C38_1.DG C32_2.aDG C32_1.DG C14_1.FA C14_0.FA C54_7.TG C34_2.DG C16_1.FA C36_0.DG C16_0.FA C34_2.aDG C16_0.MG C36_2.aDG C32_2.DG C38_2.aDG C36_5.aDG C18_0.FA C42_2.DG C38_2.DG C38_4.DG C58_5.TG C40_4.DG C44_2.DG C38_3.DG C58_8.TG C18_0.FaCN C54_6.TG C40_7.DG C44_1.DG C38_5.aDG C40_2.DG C30_1.DG C36_3.DG C20_3.FA C64_3.TG C22_4.FA C62_4.TG C34_3.DG C38_6.DG C56_2.TG C60_0.TG C34_3.aDG C38_6.aDG C18_2.FA C16_0.FaCN C38_5.DG C22_3.FA C40_6.DG C40_5.aDG C30_2.aDG C34_4.aDG C58_7.TG C18_1.FA C62_5.TG C56_8.TG C58_4.TG C40_5.DG C56_5.TG C40_3.DG C36_2.DG C18_0.MG C56_6.TG C40_6.aDG C38_4.aDG C54_5.TG C26_0.FA C20_2.FA C52_1.TG C54_3.TG C58_9.TG C26_1.FA C52_0.TG C24_0.FA C22_2.FA C52_2.TG C58_6.TG C60_2.TG C62_0.TG C24_1.FA C60_4.TG C18_2.MG C54_2.TG C20_4.FA C62_2.TG C22_5.FA C58_1.TG C54_4.TG C62_3.TG C22_1.FA C54_0.TG C50_0.TG C52_3.TG C52_4.TG C60_1.TG C60_3.TG C22_6.FA C54_1.TG C16_1.MG C56_0.TG C56_1.TG C56_3.TG C56_4.TG C62_1.TG C64_2.TG C58_0.TG C58_2.TG C58_3.TG C50_2.TG C56_7.TG C20_1.FA C40_7.aDG C50_1.TG C52_6.TG C48_0.TG C52_5.TG C64_1.TG C30_1.aDG C32_3.aDG C48_3.TG C40_2.TG C46_1.TG C44_0.TG C52_7.TG C48_1.TG C48_2.TG C42_3.TG C46_0.TG C48_4.TG C38_3.aDG C50_3.TG ID C40_7.PS C34_0.aPC C36_3.PA C36_3.PE C40_5.PI C42_5.PC C40_8.PI C32_3.PC C38_6.aPE C40_4.PI C34_2.aPC C36_5.aPC C42_5.PE C38_2.PE C24_0.aLPC C38_7.aPE C36_5.aPE C40_5.PE C40_5.aPE C36_4.PE C44_6.aPE C34_1.PA C34_3.aPC C34_4.aPE C34_2.PA C22_0.aLPC C40_4.aPE C34_3.PE C40_3.PC C42_4.PC C40_7.PI C18_0.LPC C38_5.aPE C38_1.PE C38_6.PE C40_4.PE C30_1.aPC C42_6.PI C36_5.PE C42_7.PI C18_1.LPA C26_0.aPC C36_2.aPE C40_2.PE C32_1.PA C38_3.PE C40_2.PC C42_7.PC C42_6.aPC C38_4.PE C36_3.aPE C38_5.PE C44_5.PC C40_6.PI C14_1.aLPC C40_5.aPC C40_7.aPC C28_0.PC C40_3.PE C36_6.PE C34_1.aPC C42_2.PE C42_4.aPC C42_4.PS C30_1.PI C42_6.PS C38_7.PE C36_4.aPE C16_1.LPC C38_3.PG C72_4.CL C12_0.LPC C36_1.PI C66_5.CL C20_2.LPC C38_2.PG C20_1.LPC C38_4.PG C42_7.aPC C34_1.PS C70_3.CL C34_2.PS C40_6.PG C34_3.PG C74_5.CL C34_3.PI C36_4.PG C30_0.aPE C40_2.PS C38_2.PS C42_7.PA C36_1.PS C38_2.PI C36_2.PI C28_0.aPC C70_5.CL C30_0.PG C74_6.CL C38_5.PS C42_1.PS C36_5.PI C32_1.PI C16_0.LPC C36_2.PS C40_7.PG C66_3.CL C66_4.CL C38_7.PG C18_2.LPC C38_6.PG C36_1.PG C40_5.PG C18_1.LPC C36_2.PG C26_1.LPC C20_3.LPC C34_2.PG C34_0.PS C68_4.CL C34_4.PC C20_4.LPC C38_1.PS C36_3.PG C68_5.CL C70_4.CL C38_2.PA C42_9.PE C68_6.CL C32_2.PI C34_1.PG C40_1.PS C38_5.PG C30_1.PC C40_7.PE C34_1.PC C28_2.aPE C42_5.aPE C30_1.aPE C32_0.PE C42_7.PE C42_8.PE C40_4.PS C38_3.PI C40_7.aPE C34_3.PC C38_7.PC C40_9.aPE C42_8.aPE C42_4.PI C36_4.PI C36_5.PG C28_1.aPE C32_0.PS C40_6.PS C34_2.PC C36_1.PA C22_2.aLPC C28_0.PS C30_0.PS C30_1.PE C32_2.PC C70_6.CL C42_2.PS C70_7.CL C34_2.PI C42_6.PE C34_1.PI C72_5.CL C74_7.CL C40_3.PS C36_4.PS C38_3.PS C40_9.PE C42_5.PS C74_9.CL C44_8.aPE C72_6.CL C32_1.PC C72_8.CL C30_0.PE C72_7.CL C28_0.PE C16_1.aLPC C40_6.PA C38_4.PS C36_3.PI C36_3.PS C74_8.CL C30_1.PS C36_5.PC C32_2.aPC C38_5.PI C40_8.PC C34_1.PE C42_7.aPE C38_4.PA C34_0.PC C28_1.PE C40_5.PA C36_1.PC C20_1.aLPC C38_4.PC C42_4.PE C38_6.PS C32_0.PC C44_7.aPE C38_4.PI C36_2.PC C38_5.PC C36_3.PC C42_6.aPE C36_4.PC C38_6.PC C40_6.aPE C40_8.PE C40_8.aPE C34_0.PI C20_0.aLPC C40_9.PI C30_2.aPC C68_3.CL C34_3.aPE C38_1.PC C40_6.PE C34_4.PE C30_0.PC C34_2.aPE C36_2.PA C40_7.PC C36_1.PE C40_2.PI C32_2.PA C38_3.PC C40_6.PC C18_3.aLPC C40_5.PC C34_2.PE C38_2.PC C40_4.PC C28_1.PC C36_2.PE C42_5.PI C38_3.PA C44_5.aPE C38_6.PI C18_1.aLPC C40_5.PS C18_2.aLPC C40_3.PI C32_0.aPE C34_3.PS C16_2.aLPC C32_2.PE C36_0.PG C30_2.PC C30_1.PG C38_1.PI C24_0.LPC C28_0.LPC C32_1.PE C64_3.CL C14_0.LPC C40_4.PG C32_1.PS C32_2.PG C38_1.PG C64_4.CL C62_3.CL C66_2.CL C32_0.PG C32_1.PG C24_1.LPC C34_0.PG C36_6.aPC C42_6.PA C40_3.PG C32_1.aPE C42_4.aPE C16_0.aLPC C34_0.PE C38_1.aPC C32_0.PI C36_0.PI C32_2.aPE C36_0.PA C38_3.aPC C40_2.aPC C40_1.aPC C38_2.aPC C30_0.PI C44_6.PC C34_0.PA C30_0.aPC C38_0.PI C36_1.aPC C34_1.aPE C36_0.PE C20_0.LPC C40_3.PA C40_3.aPE C36_4.aPC C30_2.aPE C26_0.PA C36_1.aPE C16_0.LPA C40_3.aPC C26_0.PC C32_0.PA C38_3.aPE C36_6.PC C30_0.PA C38_4.aPC C38_4.aPE C40_6.aPC C18_0.LPA C42_1.PE C28_1.PA C36_2.aPC C38_7.aPC C42_3.PE C38_2.aPE C40_0.PS C36_6.aPE C30_1.PA C38_6.aPC C40_4.aPC C38_5.aPC C42_5.aPC C14_0.aLPC C36_3.aPC C28_0.PA C44_7.PC C40_4.PA C32_1.aPC C40_1.PE C42_5.PA C40_8.aPC C42_6.PC C32_0.aPC ID C38_1.TG C44_4.TG C16_0.MG C44_2.DG C38_1.DG C42_0.TG C34_0.aDG C34_0.DG C40_0.TG C58_1.TG C18_1.MG C56_0.TG C56_1.TG C40_1.DG C60_2.TG C62_3.TG C54_0.TG C48_0.TG C50_0.TG C32_0.DG C40_2.TG C30_0.DG C58_2.TG C46_0.TG C26_0.FA C44_0.TG C42_0.DG C36_0.aDG C42_1.TG C46_4.TG C62_1.TG C58_0.TG C44_3.TG C44_1.DG C64_3.TG C42_2.DG C60_1.TG C40_0.DG C62_2.TG C42_2.TG C40_1.TG C42_1.DG C52_0.TG C18_2.MG C64_2.TG C22_1.FA C54_3.TG C20_2.FA C50_3.TG C48_3.TG C38_3.DG C56_4.TG C18_0.FA C24_0.FA C36_3.DG C58_5.TG C38_6.DG C54_4.TG C40_4.DG C52_6.TG C50_4.TG C50_5.TG C16_1.FA C38_5.DG C56_6.TG C16_1.MG C14_1.FA C38_2.aDG C36_1.aDG C32_1.aDG C38_0.TG C58_6.TG C24_1.FA C54_5.TG C40_5.DG C18_1.FA C22_2.FA C30_1.aDG C52_5.TG C56_5.TG C32_2.DG C52_4.TG C34_1.DG C20_1.FA C38_2.DG C58_3.TG C32_0.aDG C60_4.TG C46_2.TG C50_1.TG C56_2.TG C62_4.TG C44_1.TG C60_3.TG C30_1.DG C46_3.TG C44_2.TG C52_1.TG C62_5.TG C46_1.TG C54_1.TG C40_2.DG C48_1.TG C32_1.DG C36_1.DG C26_1.FA C52_7.TG C48_4.TG C48_2.TG C54_2.TG C52_2.TG C50_2.TG C56_3.TG C40_3.DG C14_0.FA C50_6.TG C52_3.TG C16_0.FA C34_2.DG C36_4.DG C58_4.TG C34_4.aDG C36_2.DG C18_0.MG C30_2.aDG C36_0.DG C36_3.aDG C20_3.FA C40_6.DG C38_3.aDG C38_4.DG C18_2.FA C34_3.aDG C22_4.FA C34_3.DG C54_6.TG C22_3.FA C34_1.aDG C36_4.aDG C36_2.aDG C34_2.aDG C38_4.aDG C40_7.aDG C40_6.aDG C58_7.TG C22_6.FA C18_0.FaCN C40_5.aDG C22_5.FA C54_7.TG C32_2.aDG C40_7.DG C56_7.TG C32_3.aDG C38_5.aDG C20_4.FA C38_6.aDG C16_0.FaCN C58_9.TG C56_8.TG C36_5.aDG C58_8.TG ID C40_2.PE C70_5.CL C38_3.PA C68_3.CL C30_1.aPE C36_3.aPE C38_6.PS C20_1.LPC C40_6.PS C74_9.CL C40_5.PI C40_3.PC C70_6.CL C38_2.PE C38_7.PE C36_4.aPE C32_0.PE C38_2.aPE C34_1.PE C74_7.CL C74_5.CL C30_1.PS C44_8.aPE C68_5.CL C34_0.PI C40_9.aPE C40_1.PS C42_7.PC C36_3.PE C46_7.aPE C40_2.PC C16_2.aLPC C42_5.PS C36_3.PI C36_1.PG C38_6.aPE C36_3.PA C70_7.CL C36_4.PI C42_5.PA C40_7.PC C40_5.PS C32_0.PS C38_2.PG C40_3.PG C32_2.PI C36_2.PA C40_4.PC C16_0.aLPC C42_5.aPC C32_2.PE C42_4.PS C40_6.aPC C34_1.PS C34_3.aPE C38_3.PI C34_0.PC C40_3.aPC C38_2.PC C30_1.aPC C26_1.aLPC C34_4.PE C28_0.PS C30_0.PS C40_5.aPC C40_7.PS C34_2.PE C36_2.PE C74_6.CL C32_1.PS C40_8.aPC C36_2.aPE C34_2.PI C38_1.PE C36_2.PI C40_5.PC C34_1.aPE C34_1.PG C34_4.aPE C70_4.CL C38_1.PI C40_3.aPE C30_0.PA C36_6.PE C72_4.CL C72_8.CL C44_5.PC C66_5.CL C42_1.PE C30_0.PG C32_1.PI C64_4.CL C28_1.PC C40_6.aPE C30_1.PE C28_0.PE C42_3.PE C42_5.PI C68_6.CL C40_1.aPC C66_3.CL C42_4.aPC C42_2.PE C42_6.aPE C44_6.PC C34_0.aPC C28_0.PC C64_3.CL C42_5.aPE C42_6.PS C40_4.aPE C40_5.aPE C38_6.PE C40_5.PE C38_3.aPE C46_5.aPE C46_9.aPE C72_7.CL C38_4.aPE C30_1.PI C32_1.PG C40_4.PA C42_7.aPC C36_4.PE C38_2.PI C34_1.PI C46_6.aPE C38_1.PC C44_5.aPE C36_0.PI C40_4.PE C34_1.PA C66_4.CL C40_7.aPE C18_3.aLPC C36_1.aPE C38_7.aPE C38_6.PI C40_3.PE C42_7.aPE C38_4.PE C30_0.PC C38_5.aPE C42_2.PS C42_7.PI C72_5.CL C30_0.PE C32_0.aPE C14_1.aLPC C36_5.PE C32_0.PG C40_1.PE C42_1.PS C40_8.aPE C40_6.PI C40_3.PI C44_7.PC C40_4.PI C40_7.PI C42_4.PC C46_8.aPE C42_6.PC C36_1.PI C42_6.aPC C38_0.PI C74_8.CL C30_0.aPE C38_5.PE C44_6.aPE C38_3.PE C42_8.aPE C26_0.aPC C72_6.CL C44_7.aPE C42_5.PC C68_4.CL C32_1.PE C38_1.PG C16_1.aLPC C22_0.aLPC C40_3.PA C40_2.aPC C24_0.aLPC C20_1.aLPC C40_8.PE C42_9.PE C66_2.CL C26_0.PC C40_7.PE C24_1.LPC C42_6.PE C42_4.PE C30_1.PG C26_1.LPC C42_5.PE C40_2.PI C40_6.PE C70_3.CL C42_7.PE C42_8.PE C32_0.PI C42_6.PI C32_1.PA C62_3.CL C24_0.LPC C34_0.PA C32_0.PA C30_0.PI C42_4.PI C20_0.LPC C42_4.aPE C18_1.LPA C32_2.PC C36_4.PG C40_6.PA C36_4.PC C38_4.PI C42_6.PA C38_5.PG C42_7.PA C38_5.PC C38_7.PC C36_4.aPC C34_3.PI C36_3.PG C40_7.PG C38_5.aPC C12_0.LPC C14_0.aLPC C34_3.PC C34_4.PC C36_5.aPC C38_6.aPC C40_5.PA C38_4.aPC C36_4.PS C40_6.PG C34_2.aPC C38_1.aPC C30_2.PC C36_2.aPC C34_3.PS C34_2.PG C34_2.PC C32_1.aPC C32_0.aPC C32_2.aPC C38_4.PC C38_4.PG C34_3.aPC C36_2.PG C38_6.PC C36_1.aPC C36_1.PA C36_3.aPC C36_3.PC C38_7.aPC C36_0.PE C34_2.PA C32_1.PC C32_2.PG C16_0.LPC C36_2.PC C14_0.LPC C40_5.PG C36_1.PS C34_0.PG C20_2.LPC C36_6.aPE C34_1.PC C38_5.PS C40_3.PS C40_4.aPC C38_4.PS C38_3.PG C30_2.aPC C38_5.PI C40_4.PS C38_2.PS C28_0.aPC C34_0.PE C34_2.PS C36_1.PC C40_4.PG C38_3.aPC C38_2.PA C38_3.PC C38_2.aPC C30_1.PC C38_1.PS C36_5.aPE C28_1.aPE C34_3.PE C36_3.PS C36_5.PI C30_2.aPE C36_0.PG C32_1.aPE C32_2.aPE C40_8.PC C18_0.LPC C32_0.PC C34_0.PS C38_3.PS C40_8.PI C34_2.aPE C36_1.PE C40_2.PS C36_2.PS C30_0.aPC C40_7.aPC C28_2.aPE C40_6.PC C16_0.LPA C20_0.aLPC C24_1.aLPC C20_3.LPC C20_4.LPC C18_2.aLPC C16_1.LPC C32_2.PA C38_7.PG C36_6.PC C18_2.LPC C36_5.PG C38_4.PA C18_1.aLPC C38_6.PG C36_5.PC C18_1.LPC C32_3.PC C34_3.PG ID hibition C. mTOR inhibition B. PI3k inhibition gure 4. Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. AKT, B. PI3K and C. mTOR tor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families, and lipids within family are sorted by name. 1 0.5 0 0.5 1 Neutral Lipids rol 0.3μM 3μM FA MG DG TG CL PS PI PG PA PC PE Neutral Lipids ol 0.3μM 3μM Phospholipids Control 0.3μM 3μM Phospholipids Control 0.3μM 3μM Neutral Lipids Control 0.1μM 0.3μM Phospholipids Control 0.1μM 0.3μM Neutral Lipids Control 0.1μM 0.3μM Phospholipids Control 0.1μM 0.3μM Neutral Lipids Control 0.1μM 1μM Phospholipids Control 0.1μM 1μM Phospholipids Control 0.1μM 1μM Neutral Lipids Control 0.1μM 1μM Neutral Lipids Phospholipids Fold Change mTOR inhibition B. PI3k inhibition gure 4. Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. AKT, B. PI3K and C. mTOR tor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families, and lipids within family are sorted by name. 1 0.5 0 0.5 1 Neutral Lipids rol 0.3μM 3μM FA MG DG TG CL PS PI PG PA PC PE Neutral Lipids ol 0.3μM 3μM Phospholipids Control 0.3μM 3μM Phospholipids Control 0.3μM 3μM Neutral Lipids Control 0.1μM 0.3μM Phospholipids Control 0.1μM 0.3μM Neutral Lipids Control 0.1μM 0.3μM Phospholipids Control 0.1μM 0.3μM Neutral Lipids Control 0.1μM 1μM Phospholipids Control 0.1μM 1μM Phospholipids Control 0.1μM 1μM Neutral Lipids Control 0.1μM 1μM Neutral Lipids Phospholipids Fold Change C. mTOR inhibition C. mTOR inhibition A. AKT inhibition A. AKT inhibition B. PI3k inhibition B. C60_1.TG C54_0.TG C64_1.TG C56_3.TG C58_0.TG C62_0.TG C58_1.TG C58_3.TG C50_3.TG C64_2.TG C40_0.TG C42_0.TG C42_1.TG C44_3.TG C54_5.TG C40_1.TG C44_4.TG C46_3.TG C40_0.DG C38_0.TG C40_1.DG C42_1.DG C64_3.TG C50_4.TG C30_0.DG C50_5.TG C54_1.TG C56_1.TG C46_4.TG C50_6.TG C62_4.TG C56_5.TG C56_2.TG C48_1.TG C58_5.TG C58_8.TG C46_0.TG C62_3.TG C56_0.TG C48_2.TG C56_6.TG C50_1.TG C54_6.TG C52_1.TG C58_4.TG C52_5.TG C54_7.TG C48_0.TG C56_8.TG C36_0.aDG C58_2.TG C32_0.DG C56_4.TG C50_2.TG C52_4.TG C54_4.TG C62_5.TG C40_2.TG C58_9.TG C48_4.TG C42_3.TG C52_6.TG C42_2.TG C44_0.TG C56_7.TG C44_1.TG C48_3.TG C52_7.TG C38_1.TG C44_2.TG C58_6.TG C42_0.DG C58_7.TG C46_1.TG C46_2.TG C34_0.DG C50_0.TG C62_1.TG C54_2.TG C60_2.TG C60_4.TG C32_0.aDG C52_3.TG C60_0.TG C60_3.TG C62_2.TG C52_0.TG C34_0.aDG C52_2.TG C32_2.aDG C18_2.MG C34_1.aDG C34_2.aDG C36_0.DG C24_0.FA C38_6.DG C16_0.MG C36_3.aDG C38_1.DG C18_0.MG C36_1.aDG C18_1.MG C36_1.DG C54_3.TG C32_1.aDG C34_3.aDG C30_1.aDG C36_4.aDG C22_2.FA C22_1.FA C40_3.DG C44_1.DG C20_2.FA C20_3.FA C22_3.FA C20_4.FA C34_4.aDG C42_2.DG C18_0.FaCN C20_1.FA C40_7.aDG C22_4.FA C44_2.DG C40_6.DG C30_2.aDG C22_6.FA C40_5.DG C18_0.FA C38_5.DG C22_5.FA C40_2.DG C18_1.FA C26_1.FA C30_1.DG C38_2.DG C32_3.aDG C36_2.DG C18_2.FA C24_1.FA C38_3.DG C38_4.DG C14_1.FA C16_0.FA C32_2.DG C32_1.DG C36_2.aDG C34_1.DG C40_7.DG C26_0.FA C38_6.aDG C38_4.aDG C38_5.aDG C38_3.aDG C36_3.DG C14_0.FA C16_0.FaCN C16_1.FA C34_2.DG C16_1.MG C34_3.DG C40_6.aDG C36_5.aDG C40_4.DG C38_2.aDG C40_5.aDG ID C36_0.PI C14_1.aLPC C16_0.LPA C40_0.PS C38_0.PI C30_1.PA C18_0.LPA C40_3.PA C40_4.PA C34_0.PA C28_0.PA C30_0.PA C32_0.PA C26_0.PC C26_0.PA C32_2.PA C16_2.aLPC C40_5.PE C28_1.PA C36_0.PA C16_0.aLPC C44_6.aPE C40_1.PE C42_1.PE C42_4.PC C36_4.aPC C36_5.aPC C40_3.aPC C28_0.PC C42_6.PC C20_0.LPC C32_0.PI C18_0.LPC C40_4.aPC C36_1.aPE C44_6.PC C36_6.PE C30_0.PI C30_2.aPC C34_1.PA C34_2.PA C38_7.aPC C36_3.PA C44_7.PC C32_1.PA C42_5.PA C36_0.PE C34_0.PC C42_6.PS C20_2.LPC C20_3.LPC C42_9.PE C42_7.PI C14_0.LPC C30_1.PS C20_4.LPC C34_3.PS C38_4.PA C40_8.PI C16_1.LPC C18_3.aLPC C28_1.PE C62_3.CL C42_7.PE C34_4.PC C74_8.CL C18_1.LPC C18_2.LPC C36_4.PS C28_0.PE C40_3.PG C40_4.PG C38_7.PG C38_5.PS C70_5.CL C40_8.PC C40_9.aPE C38_7.PC C40_5.PG C40_9.PI C72_6.CL C34_4.PE C40_7.PG C42_8.PE C40_6.PG C42_6.PA C74_7.CL C30_0.PE C38_3.PS C42_8.aPE C72_7.CL C44_7.aPE C40_7.PE C66_5.CL C32_1.PE C70_3.CL C42_4.PI C74_6.CL C30_2.PC C70_6.CL C20_1.LPC C28_0.LPC C38_6.PG C72_8.CL C42_5.aPE C40_9.PE C72_5.CL C34_1.PE C68_5.CL C30_1.PE C74_9.CL C16_1.aLPC C38_6.PS C70_7.CL C42_6.PE C66_4.CL C38_2.PS C38_1.PG C38_4.PG C40_6.PA C38_5.PG C32_2.PE C34_2.PS C36_5.PI C68_6.CL C38_2.PG C36_1.PS C32_2.PI C40_6.PS C40_7.PS C38_3.PG C70_4.CL C36_2.PA C68_4.CL C34_3.PI C38_4.PS C66_2.CL C34_1.PS C40_4.PS C34_3.PC C36_2.PS C42_6.aPC C12_0.LPC C42_2.PS C66_3.CL C32_0.PE C34_1.PG C36_4.PG C32_1.PS C18_1.aLPC C30_2.aPE C36_4.PI C64_4.CL C34_2.PE C16_0.LPC C42_4.PE C36_6.aPE C38_4.aPC C24_0.aLPC C36_3.aPC C38_3.aPE C30_1.aPC C36_4.aPE C18_1.LPA C38_6.aPC C38_5.aPC C40_5.PA C38_2.aPC C28_1.PC C40_4.PE C38_2.aPE C40_3.PE C38_6.PE C38_4.PE C38_4.aPE C36_2.aPC C68_3.CL C36_6.aPC C42_2.PE C42_5.PI C30_0.PC C42_4.aPC C38_1.aPC C40_7.aPC C34_1.aPE C40_8.aPC C42_6.PI C40_6.aPC C74_5.CL C20_1.aLPC C38_3.aPC C40_5.aPC C40_3.PC C38_3.PE C38_3.PA C40_6.PC C42_3.PE C40_5.PC C38_5.PE C42_5.PS C42_5.PC C32_1.aPC C40_7.PI C36_4.PE C34_0.PI C38_4.PC C38_1.PE C38_1.PC C38_6.PC C22_0.aLPC C30_0.PG C38_2.PE C42_5.PE C26_0.aPC C40_1.aPC C44_5.PC C30_0.aPC C40_2.PC C34_1.aPC C40_2.PE C40_4.PC C36_2.aPE C32_2.aPC C34_2.aPC C40_5.PI C40_4.PI C34_0.PS C40_6.PI C42_7.PC C36_5.aPE C36_5.PE C32_0.PC C38_3.PC C36_1.aPC C36_3.aPE C30_1.PC C32_2.aPE C36_3.PE C40_8.PE C36_6.PC C38_3.PI C40_2.PS C32_1.PI C36_3.PI C24_0.LPC C30_0.aPE C42_7.aPC C36_2.PI C34_0.aPC C36_1.PG C34_2.PC C40_2.aPC C26_1.LPC C40_1.PS C28_1.aPE C42_7.aPE C24_1.LPC C42_4.aPE C34_1.PI C34_1.PC C34_3.PE C34_2.PI C34_3.PG C32_1.PC C34_2.PG C40_7.PC C36_2.PE C40_3.PS C36_3.PG C32_2.PG C36_3.PS C34_0.PG C40_6.aPE C32_2.PC C40_7.aPE C28_2.aPE C38_2.PI C42_6.aPE C38_1.PS C40_8.aPE C40_5.PS C36_2.PG C30_1.PI C36_5.PG C20_0.aLPC C36_0.PG C72_4.CL C34_3.aPC C42_4.PS C32_0.aPC C40_3.aPE C40_3.PI C34_4.aPE C38_5.PC C28_0.aPC C38_7.PE C32_0.PG C38_5.aPE C38_2.PA C32_0.aPE C38_5.PI C32_0.PS C14_0.aLPC C64_3.CL C30_1.PG C42_5.aPC C36_1.PI C34_2.aPE C38_6.aPE C36_5.PC C36_1.PC C32_1.aPE C44_8.aPE C40_2.PI C36_3.PC C38_2.PC C22_2.aLPC C38_7.aPE C40_5.aPE C30_0.PS C34_3.aPE C36_1.PA C38_6.PI C36_4.PC C42_7.PA C32_3.PC C32_1.PG C28_0.PS C38_1.PI C44_5.aPE C42_1.PS C38_4.PI C34_0.PE C36_1.PE C40_6.PE C40_4.aPE C30_1.aPE C36_2.PC C18_2.aLPC ID C38_1.TG C30_2.aDG C38_3.aDG C40_5.aDG C18_0.FaCN C32_1.aDG C36_5.aDG C18_0.FA C38_5.aDG C38_4.aDG C40_7.aDG C32_2.aDG C14_1.FA C38_6.aDG C16_0.FA C34_2.DG C34_3.DG C30_1.DG C38_4.DG C40_6.aDG C32_1.DG C32_0.aDG C32_2.DG C36_2.aDG C14_0.FA C16_1.FA C36_4.DG C38_0.TG C34_3.aDG C36_4.aDG C30_1.aDG C34_1.aDG C34_2.aDG C36_3.aDG C18_1.FA C36_1.aDG C16_0.FaCN C18_2.FA C38_2.aDG C40_2.TG C32_3.aDG C38_3.DG C24_1.FA C36_0.aDG C38_2.DG C40_3.DG C16_0.MG C36_1.DG C34_0.aDG C20_4.FA C18_0.MG C26_0.FA C32_0.DG C36_2.DG C18_2.MG C42_3.TG C34_1.DG C38_5.DG C16_1.MG C24_0.FA C36_3.DG C34_4.aDG C30_0.DG C56_8.TG C52_5.TG C54_7.TG C56_7.TG C58_7.TG C58_8.TG C48_3.TG C50_4.TG C52_7.TG C56_4.TG C52_4.TG C54_5.TG C56_5.TG C58_6.TG C50_5.TG C58_5.TG C20_2.FA C56_6.TG C58_4.TG C54_6.TG C50_3.TG C52_6.TG C50_6.TG C58_9.TG C20_1.FA C62_0.TG C22_5.FA C38_6.DG C40_1.DG C38_1.DG C40_2.DG C26_1.FA C36_0.DG C40_1.TG C40_0.DG C52_0.TG C40_5.DG C22_4.FA C42_0.DG C22_2.FA C42_1.DG C20_3.FA C58_0.TG C40_4.DG C44_4.TG C42_2.DG C42_0.TG C48_0.TG C60_0.TG C40_0.TG C56_0.TG C50_0.TG C44_1.DG C34_0.DG C42_1.TG C44_2.DG C60_2.TG C56_1.TG C60_1.TG C22_1.FA C46_0.TG C44_1.TG C58_1.TG C40_6.DG C46_3.TG C52_1.TG C62_1.TG C62_5.TG C62_3.TG C22_6.FA C44_3.TG C62_2.TG C54_1.TG C62_4.TG C50_1.TG C48_1.TG C58_2.TG C42_2.TG C44_0.TG C46_1.TG C60_4.TG C54_0.TG C52_3.TG C64_1.TG C54_2.TG C52_2.TG C56_2.TG C60_3.TG C58_3.TG C48_4.TG C56_3.TG C46_2.TG C50_2.TG C46_4.TG C18_1.MG C64_2.TG C40_7.DG C64_3.TG C44_2.TG C54_4.TG C22_3.FA C48_2.TG C54_3.TG ID C28_1.PA C30_2.aPC C36_0.aPC C72_4.CL C44_8.aPE C46_9.aPE C46_8.aPE C36_5.aPC C40_9.PI C38_7.aPC C40_8.aPC C28_1.PE C42_7.aPC C40_6.aPE C30_1.aPC C42_1.PE C36_6.aPC C36_1.aPE C40_8.PI C38_0.PI C42_7.PC C40_5.aPE C18_0.LPC C14_1.aLPC C16_1.aLPC C38_6.aPC C40_3.aPE C18_2.aLPC C36_1.PC C38_6.PC C70_3.CL C42_4.PC C26_0.PC C70_4.CL C40_8.PC C40_6.PE C74_8.CL C40_1.PE C40_5.aPC C40_3.PC C42_5.PS C40_7.PC C46_5.aPE C40_2.PC C40_7.aPC C44_5.PC C40_6.PC C38_6.aPE C40_4.PI C40_6.PI C26_0.aPC C40_5.PC C42_6.aPC C40_3.PE C40_5.PI C38_1.PG C42_6.PE C42_8.PE C42_5.PI C42_5.PC C40_4.PE C38_4.aPE C44_7.PC C40_1.aPC C16_2.aLPC C42_6.PC C72_7.CL C40_6.aPC C40_4.PC C40_3.PI C38_2.PC C36_4.aPE C38_3.aPE C40_4.aPE C40_6.PS C42_6.PI C42_7.aPE C46_7.aPE C44_7.aPE C46_6.aPE C42_6.aPE C44_6.aPE C36_0.PA C72_5.CL C22_1.aLPC C42_5.aPE C74_7.CL C42_8.aPE C44_5.aPE C74_5.CL C20_1.aLPC C40_9.PE C38_1.PC C42_6.PS C72_6.CL C38_5.aPE C40_7.aPE C42_4.aPE C40_8.aPE C28_0.LPC C38_7.aPE C36_5.aPE C40_9.aPE C12_0.LPC C40_5.PA C32_1.PA C34_1.PA C40_0.PS C20_4.LPC C40_6.PA C42_6.PA C32_2.PA C38_4.PA C34_3.aPC C36_4.aPC C40_3.aPC C36_6.PC C42_4.aPC C42_3.PE C34_0.PC C38_1.aPC C38_6.PE C38_2.aPC C40_2.aPC C20_1.LPC C70_5.CL C38_3.PC C36_6.aPE C42_7.PE C42_2.PE C44_6.PC C28_0.PE C66_3.CL C38_7.PC C40_5.PE C38_2.aPE C36_1.aPC C40_2.PE C42_9.PE C40_5.PS C42_1.PS C74_9.CL C36_1.PG C38_3.aPC C42_4.PI C24_0.LPC C38_3.PA C70_6.CL C20_2.LPC C38_2.PE C36_3.aPE C40_7.PI C42_5.aPC C42_4.PE C42_2.PS C18_1.aLPC C74_6.CL C38_1.PE C42_7.PI C28_0.PC C38_5.aPC C38_4.aPC C72_8.CL C42_5.PE C40_4.aPC C34_0.PI C20_0.LPC C34_1.PG C38_6.PI C38_3.PI C34_0.aPC C34_0.PA C38_3.PE C38_4.PI C38_4.PE C38_1.PI C34_1.PC C40_2.PI C26_1.LPC C30_0.PC C36_2.aPC C36_4.PI C36_3.aPC C18_3.aLPC C36_6.PE C38_4.PC C36_2.aPE C40_1.PS C36_1.PA C38_5.PC C40_7.PE C42_4.PS C38_2.PI C40_7.PG C36_1.PS C68_4.CL C40_8.PE C38_1.PS C36_4.PC C40_3.PA C38_5.PE C36_4.PE C28_1.aPE C28_0.aPC C70_7.CL C40_7.PS C36_1.PI C40_2.PS C66_4.CL C36_2.PS C62_3.CL C16_0.LPA C32_1.PC C36_3.PE C30_0.aPC C66_5.CL C38_2.PS C30_1.PE C34_1.aPE C38_7.PE C32_1.PI C22_0.aLPC C28_0.PA C30_0.PA C36_5.PE C34_4.aPE C38_3.PS C68_6.CL C34_1.PE C36_2.PI C34_0.PE C28_2.aPE C28_1.PC C36_0.PE C34_1.PS C36_3.PI C32_2.aPC C24_1.LPC C32_0.PG C68_5.CL C36_3.PC C68_3.CL C64_3.CL C16_0.LPC C30_0.PG C34_1.PI C34_0.PS C36_0.PI C36_5.PI C32_0.PI C38_2.PA C34_2.aPC C38_5.PI C36_2.PC C36_1.PE C36_5.PC C32_0.PA C32_0.PE C66_2.CL C32_0.PC C30_0.PE C38_3.PG C38_5.PG C40_4.PG C38_4.PG C40_5.PG C30_1.PA C42_7.PA C16_1.LPC C36_0.PG C36_2.PG C32_3.PC C40_3.PG C34_2.PA C26_1.aLPC C38_2.PG C34_1.aPC C30_1.PC C18_1.LPC C36_2.PE C32_0.PS C40_4.PS C34_2.PC C40_3.PS C32_1.aPC C64_4.CL C16_0.aLPC C32_1.PG C36_3.PS C18_0.LPA C32_1.PE C38_5.PS C34_2.PI C34_3.aPE C30_0.PI C30_1.PI C32_2.PE C32_0.aPE C14_0.aLPC C34_3.PE C42_5.PA C30_0.aPE C20_0.aLPC C34_3.PS C30_1.PG C38_4.PS C40_6.PG C34_2.PS C32_2.PI C32_1.PS C34_3.PI C18_1.LPA C34_4.PE C34_2.PE C34_2.aPE C34_2.PG C36_5.PG C34_3.PC C40_4.PA C32_0.aPC C36_2.PA C32_2.PG C22_2.aLPC C18_2.LPC C32_1.aPE C34_4.PC C24_0.aLPC C38_6.PS C30_2.aPE C32_2.PC C32_2.aPE C38_7.PG C20_3.LPC C28_0.PS C30_0.PS C36_4.PG C24_1.aLPC C30_1.PS C14_0.LPC C34_0.PG C34_3.PG C30_2.PC C36_4.PS C36_3.PA C30_1.aPE C36_3.PG C38_6.PG ID C44_3.TG C64_2.TG C46_4.TG C48_4.TG C44_2.TG C44_4.TG C52_7.TG C46_2.TG C50_5.TG C50_6.TG C64_1.TG C46_3.TG C52_6.TG C40_1.TG C44_1.TG C42_1.TG C42_2.TG C62_0.TG C38_0.TG C40_2.TG C38_1.TG C42_3.TG C52_1.TG C34_0.DG C48_1.TG C54_1.TG C50_1.TG C52_0.TG C40_0.TG C36_0.DG C62_2.TG C42_0.TG C46_1.TG C62_1.TG C42_1.DG C38_1.DG C50_0.TG C34_0.aDG C48_0.TG C58_1.TG C54_0.TG C36_1.aDG C58_0.TG C60_0.TG C30_0.DG C46_0.TG C36_0.aDG C56_1.TG C60_2.TG C42_0.DG C44_0.TG C40_0.DG 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C42_7.PC C16_2.aLPC C30_0.PA C36_6.PE C40_3.aPE C40_5.PE C40_6.PE C30_1.PE C30_0.PG C34_0.PI C28_1.PC C34_0.PS C40_6.PS C38_4.aPE C64_3.CL C32_1.PG C42_7.aPC C42_7.PI C40_4.aPE C24_1.aLPC C34_1.PI C38_2.PI C20_0.LPC C42_6.PE C72_5.CL C42_4.PE C38_1.PG C62_3.CL C40_5.aPE C42_4.aPE C42_3.PE C40_2.PC C42_4.PC C36_4.aPE C32_1.PE C36_1.aPE C32_0.PE C26_0.aPC C26_0.PC C30_0.aPE C40_3.PI C44_7.PC C42_6.aPC C44_5.PC C42_2.PE C36_1.PI C30_0.PC C42_5.PI C20_1.aLPC C70_3.CL C40_1.PS C38_2.aPE C42_6.PI C38_6.PS C28_0.PE C42_1.PS C38_1.PI C64_4.CL C28_0.PC C30_0.PE C36_3.aPE C40_2.PI C40_3.PE C38_2.PG C24_1.LPC C24_0.aLPC C42_5.PS C40_4.PE C32_0.PI C42_6.PS C44_6.PC C46_5.aPE C30_0.PI C40_4.PI C42_4.PI C26_1.LPC C40_3.PA C32_0.aPE C38_3.aPE ID C32_0.DG C40_0.DG C36_3.aDG C36_4.aDG C36_1.aDG C32_0.aDG C34_0.DG C42_0.DG C32_1.aDG C34_0.aDG C46_2.TG C42_2.TG C44_1.TG C40_1.TG C40_0.TG C42_1.TG C42_0.TG C44_2.TG C46_3.TG C30_0.DG C44_4.TG C46_4.TG C38_0.TG C38_1.TG C50_5.TG C36_0.aDG C44_3.TG C50_4.TG C34_1.DG C42_1.DG C18_1.MG C36_1.DG C40_1.DG C50_6.TG C34_1.aDG C38_1.DG C32_2.aDG C32_1.DG C14_1.FA C14_0.FA C54_7.TG C34_2.DG C16_1.FA C36_0.DG C16_0.FA C34_2.aDG C16_0.MG C36_2.aDG C32_2.DG C38_2.aDG C36_5.aDG C18_0.FA C42_2.DG C38_2.DG C38_4.DG C58_5.TG C40_4.DG C44_2.DG C38_3.DG C58_8.TG C18_0.FaCN C54_6.TG C40_7.DG C44_1.DG C38_5.aDG C40_2.DG C30_1.DG C36_3.DG C20_3.FA C64_3.TG C22_4.FA C62_4.TG C34_3.DG C38_6.DG C56_2.TG C60_0.TG C34_3.aDG C38_6.aDG C18_2.FA C16_0.FaCN C38_5.DG C22_3.FA C40_6.DG C40_5.aDG C30_2.aDG C34_4.aDG C58_7.TG C18_1.FA C62_5.TG C56_8.TG C58_4.TG C40_5.DG C56_5.TG C40_3.DG C36_2.DG C18_0.MG C56_6.TG C40_6.aDG C38_4.aDG C54_5.TG C26_0.FA C20_2.FA C52_1.TG C54_3.TG C58_9.TG C26_1.FA C52_0.TG C24_0.FA C22_2.FA C52_2.TG C58_6.TG C60_2.TG C62_0.TG C24_1.FA C60_4.TG C18_2.MG C54_2.TG C20_4.FA C62_2.TG C22_5.FA C58_1.TG C54_4.TG C62_3.TG C22_1.FA C54_0.TG C50_0.TG C52_3.TG C52_4.TG C60_1.TG C60_3.TG C22_6.FA C54_1.TG C16_1.MG C56_0.TG C56_1.TG C56_3.TG C56_4.TG C62_1.TG C64_2.TG C58_0.TG C58_2.TG C58_3.TG C50_2.TG C56_7.TG C20_1.FA C40_7.aDG C50_1.TG C52_6.TG C48_0.TG C52_5.TG C64_1.TG C30_1.aDG C32_3.aDG C48_3.TG C40_2.TG C46_1.TG C44_0.TG C52_7.TG C48_1.TG C48_2.TG C42_3.TG C46_0.TG C48_4.TG C38_3.aDG C50_3.TG ID C40_7.PS C34_0.aPC C36_3.PA C36_3.PE C40_5.PI C42_5.PC C40_8.PI C32_3.PC C38_6.aPE C40_4.PI C34_2.aPC C36_5.aPC C42_5.PE C38_2.PE C24_0.aLPC C38_7.aPE C36_5.aPE C40_5.PE C40_5.aPE C36_4.PE C44_6.aPE C34_1.PA C34_3.aPC C34_4.aPE C34_2.PA C22_0.aLPC C40_4.aPE C34_3.PE C40_3.PC C42_4.PC C40_7.PI C18_0.LPC C38_5.aPE C38_1.PE C38_6.PE C40_4.PE C30_1.aPC C42_6.PI C36_5.PE C42_7.PI C18_1.LPA C26_0.aPC C36_2.aPE C40_2.PE C32_1.PA C38_3.PE C40_2.PC C42_7.PC C42_6.aPC C38_4.PE C36_3.aPE C38_5.PE C44_5.PC C40_6.PI C14_1.aLPC C40_5.aPC C40_7.aPC C28_0.PC C40_3.PE C36_6.PE C34_1.aPC C42_2.PE C42_4.aPC C42_4.PS C30_1.PI C42_6.PS C38_7.PE C36_4.aPE C16_1.LPC C38_3.PG C72_4.CL C12_0.LPC C36_1.PI C66_5.CL C20_2.LPC C38_2.PG C20_1.LPC C38_4.PG C42_7.aPC C34_1.PS C70_3.CL C34_2.PS C40_6.PG C34_3.PG C74_5.CL C34_3.PI C36_4.PG C30_0.aPE C40_2.PS C38_2.PS C42_7.PA C36_1.PS C38_2.PI C36_2.PI C28_0.aPC C70_5.CL C30_0.PG C74_6.CL C38_5.PS C42_1.PS C36_5.PI C32_1.PI C16_0.LPC C36_2.PS C40_7.PG C66_3.CL C66_4.CL C38_7.PG C18_2.LPC C38_6.PG C36_1.PG C40_5.PG C18_1.LPC C36_2.PG C26_1.LPC C20_3.LPC C34_2.PG C34_0.PS C68_4.CL C34_4.PC C20_4.LPC C38_1.PS C36_3.PG C68_5.CL C70_4.CL C38_2.PA C42_9.PE C68_6.CL C32_2.PI C34_1.PG C40_1.PS C38_5.PG C30_1.PC C40_7.PE C34_1.PC C28_2.aPE C42_5.aPE C30_1.aPE C32_0.PE C42_7.PE C42_8.PE C40_4.PS C38_3.PI C40_7.aPE C34_3.PC C38_7.PC C40_9.aPE C42_8.aPE C42_4.PI C36_4.PI C36_5.PG C28_1.aPE C32_0.PS C40_6.PS C34_2.PC C36_1.PA C22_2.aLPC C28_0.PS C30_0.PS C30_1.PE C32_2.PC C70_6.CL C42_2.PS C70_7.CL C34_2.PI C42_6.PE C34_1.PI C72_5.CL C74_7.CL C40_3.PS C36_4.PS C38_3.PS C40_9.PE C42_5.PS C74_9.CL C44_8.aPE C72_6.CL C32_1.PC C72_8.CL C30_0.PE C72_7.CL C28_0.PE C16_1.aLPC C40_6.PA C38_4.PS C36_3.PI C36_3.PS C74_8.CL C30_1.PS C36_5.PC C32_2.aPC C38_5.PI C40_8.PC C34_1.PE C42_7.aPE C38_4.PA C34_0.PC C28_1.PE C40_5.PA C36_1.PC C20_1.aLPC C38_4.PC C42_4.PE C38_6.PS C32_0.PC C44_7.aPE C38_4.PI C36_2.PC C38_5.PC C36_3.PC C42_6.aPE C36_4.PC C38_6.PC C40_6.aPE C40_8.PE C40_8.aPE C34_0.PI C20_0.aLPC C40_9.PI C30_2.aPC C68_3.CL C34_3.aPE C38_1.PC C40_6.PE C34_4.PE C30_0.PC C34_2.aPE C36_2.PA C40_7.PC C36_1.PE C40_2.PI C32_2.PA C38_3.PC C40_6.PC C18_3.aLPC C40_5.PC C34_2.PE C38_2.PC C40_4.PC C28_1.PC C36_2.PE C42_5.PI C38_3.PA C44_5.aPE C38_6.PI C18_1.aLPC C40_5.PS C18_2.aLPC C40_3.PI C32_0.aPE C34_3.PS C16_2.aLPC C32_2.PE C36_0.PG C30_2.PC C30_1.PG C38_1.PI C24_0.LPC C28_0.LPC C32_1.PE C64_3.CL C14_0.LPC C40_4.PG C32_1.PS C32_2.PG C38_1.PG C64_4.CL C62_3.CL C66_2.CL C32_0.PG C32_1.PG C24_1.LPC C34_0.PG C36_6.aPC C42_6.PA C40_3.PG C32_1.aPE C42_4.aPE C16_0.aLPC C34_0.PE C38_1.aPC C32_0.PI C36_0.PI C32_2.aPE C36_0.PA C38_3.aPC C40_2.aPC C40_1.aPC C38_2.aPC C30_0.PI C44_6.PC C34_0.PA C30_0.aPC C38_0.PI C36_1.aPC C34_1.aPE C36_0.PE C20_0.LPC C40_3.PA C40_3.aPE C36_4.aPC C30_2.aPE C26_0.PA C36_1.aPE C16_0.LPA C40_3.aPC C26_0.PC C32_0.PA C38_3.aPE C36_6.PC C30_0.PA C38_4.aPC C38_4.aPE C40_6.aPC C18_0.LPA C42_1.PE C28_1.PA C36_2.aPC C38_7.aPC C42_3.PE C38_2.aPE C40_0.PS C36_6.aPE C30_1.PA C38_6.aPC C40_4.aPC C38_5.aPC C42_5.aPC C14_0.aLPC C36_3.aPC C28_0.PA C44_7.PC C40_4.PA C32_1.aPC C40_1.PE C42_5.PA C40_8.aPC C42_6.PC C32_0.aPC ID C38_1.TG C44_4.TG C16_0.MG C44_2.DG C38_1.DG C42_0.TG C34_0.aDG C34_0.DG C40_0.TG C58_1.TG C18_1.MG C56_0.TG C56_1.TG C40_1.DG C60_2.TG C62_3.TG C54_0.TG C48_0.TG C50_0.TG C32_0.DG C40_2.TG C30_0.DG C58_2.TG C46_0.TG C26_0.FA C44_0.TG C42_0.DG C36_0.aDG C42_1.TG C46_4.TG C62_1.TG C58_0.TG C44_3.TG C44_1.DG C64_3.TG C42_2.DG C60_1.TG C40_0.DG C62_2.TG C42_2.TG C40_1.TG C42_1.DG C52_0.TG C18_2.MG C64_2.TG C22_1.FA C54_3.TG C20_2.FA C50_3.TG C48_3.TG C38_3.DG C56_4.TG C18_0.FA C24_0.FA C36_3.DG C58_5.TG C38_6.DG C54_4.TG C40_4.DG C52_6.TG C50_4.TG C50_5.TG C16_1.FA C38_5.DG C56_6.TG C16_1.MG C14_1.FA C38_2.aDG C36_1.aDG C32_1.aDG C38_0.TG C58_6.TG C24_1.FA C54_5.TG C40_5.DG C18_1.FA C22_2.FA C30_1.aDG C52_5.TG C56_5.TG C32_2.DG C52_4.TG C34_1.DG C20_1.FA C38_2.DG C58_3.TG C32_0.aDG C60_4.TG C46_2.TG C50_1.TG C56_2.TG C62_4.TG C44_1.TG C60_3.TG C30_1.DG C46_3.TG C44_2.TG C52_1.TG C62_5.TG C46_1.TG C54_1.TG C40_2.DG C48_1.TG C32_1.DG C36_1.DG C26_1.FA C52_7.TG C48_4.TG C48_2.TG C54_2.TG C52_2.TG C50_2.TG C56_3.TG C40_3.DG C14_0.FA C50_6.TG C52_3.TG C16_0.FA C34_2.DG C36_4.DG C58_4.TG C34_4.aDG C36_2.DG C18_0.MG C30_2.aDG C36_0.DG C36_3.aDG C20_3.FA C40_6.DG C38_3.aDG C38_4.DG C18_2.FA C34_3.aDG C22_4.FA C34_3.DG C54_6.TG C22_3.FA C34_1.aDG C36_4.aDG C36_2.aDG C34_2.aDG C38_4.aDG C40_7.aDG C40_6.aDG C58_7.TG C22_6.FA C18_0.FaCN C40_5.aDG C22_5.FA C54_7.TG C32_2.aDG C40_7.DG C56_7.TG C32_3.aDG C38_5.aDG C20_4.FA C38_6.aDG C16_0.FaCN C58_9.TG C56_8.TG C36_5.aDG C58_8.TG ID C40_2.PE C70_5.CL C38_3.PA C68_3.CL C30_1.aPE C36_3.aPE C38_6.PS C20_1.LPC C40_6.PS C74_9.CL C40_5.PI C40_3.PC C70_6.CL C38_2.PE C38_7.PE C36_4.aPE C32_0.PE C38_2.aPE C34_1.PE C74_7.CL C74_5.CL C30_1.PS C44_8.aPE C68_5.CL C34_0.PI C40_9.aPE C40_1.PS C42_7.PC C36_3.PE C46_7.aPE C40_2.PC C16_2.aLPC C42_5.PS C36_3.PI C36_1.PG C38_6.aPE C36_3.PA C70_7.CL C36_4.PI C42_5.PA C40_7.PC C40_5.PS C32_0.PS C38_2.PG C40_3.PG C32_2.PI C36_2.PA C40_4.PC C16_0.aLPC C42_5.aPC C32_2.PE C42_4.PS C40_6.aPC C34_1.PS C34_3.aPE C38_3.PI C34_0.PC C40_3.aPC C38_2.PC C30_1.aPC C26_1.aLPC C34_4.PE C28_0.PS C30_0.PS C40_5.aPC C40_7.PS C34_2.PE C36_2.PE C74_6.CL C32_1.PS C40_8.aPC C36_2.aPE C34_2.PI C38_1.PE C36_2.PI C40_5.PC C34_1.aPE C34_1.PG C34_4.aPE C70_4.CL C38_1.PI C40_3.aPE C30_0.PA C36_6.PE C72_4.CL C72_8.CL C44_5.PC C66_5.CL C42_1.PE C30_0.PG C32_1.PI C64_4.CL C28_1.PC C40_6.aPE C30_1.PE C28_0.PE C42_3.PE C42_5.PI C68_6.CL C40_1.aPC C66_3.CL C42_4.aPC C42_2.PE C42_6.aPE C44_6.PC C34_0.aPC C28_0.PC C64_3.CL C42_5.aPE C42_6.PS C40_4.aPE C40_5.aPE C38_6.PE C40_5.PE C38_3.aPE C46_5.aPE C46_9.aPE C72_7.CL C38_4.aPE C30_1.PI C32_1.PG C40_4.PA C42_7.aPC C36_4.PE C38_2.PI C34_1.PI C46_6.aPE C38_1.PC C44_5.aPE C36_0.PI C40_4.PE C34_1.PA C66_4.CL C40_7.aPE C18_3.aLPC C36_1.aPE C38_7.aPE C38_6.PI C40_3.PE C42_7.aPE C38_4.PE C30_0.PC C38_5.aPE C42_2.PS C42_7.PI C72_5.CL C30_0.PE C32_0.aPE C14_1.aLPC C36_5.PE C32_0.PG C40_1.PE C42_1.PS C40_8.aPE C40_6.PI C40_3.PI C44_7.PC C40_4.PI C40_7.PI C42_4.PC C46_8.aPE C42_6.PC C36_1.PI C42_6.aPC C38_0.PI C74_8.CL C30_0.aPE C38_5.PE C44_6.aPE C38_3.PE C42_8.aPE C26_0.aPC C72_6.CL C44_7.aPE C42_5.PC C68_4.CL C32_1.PE C38_1.PG C16_1.aLPC C22_0.aLPC C40_3.PA C40_2.aPC C24_0.aLPC C20_1.aLPC C40_8.PE C42_9.PE C66_2.CL C26_0.PC C40_7.PE C24_1.LPC C42_6.PE C42_4.PE C30_1.PG C26_1.LPC C42_5.PE C40_2.PI C40_6.PE C70_3.CL C42_7.PE C42_8.PE C32_0.PI C42_6.PI C32_1.PA C62_3.CL C24_0.LPC C34_0.PA C32_0.PA C30_0.PI C42_4.PI C20_0.LPC C42_4.aPE C18_1.LPA C32_2.PC C36_4.PG C40_6.PA C36_4.PC C38_4.PI C42_6.PA C38_5.PG C42_7.PA C38_5.PC C38_7.PC C36_4.aPC C34_3.PI C36_3.PG C40_7.PG C38_5.aPC C12_0.LPC C14_0.aLPC C34_3.PC C34_4.PC C36_5.aPC C38_6.aPC C40_5.PA C38_4.aPC C36_4.PS C40_6.PG C34_2.aPC C38_1.aPC C30_2.PC C36_2.aPC C34_3.PS C34_2.PG C34_2.PC C32_1.aPC C32_0.aPC C32_2.aPC C38_4.PC C38_4.PG C34_3.aPC C36_2.PG C38_6.PC C36_1.aPC C36_1.PA C36_3.aPC C36_3.PC C38_7.aPC C36_0.PE C34_2.PA C32_1.PC C32_2.PG C16_0.LPC C36_2.PC C14_0.LPC C40_5.PG C36_1.PS C34_0.PG C20_2.LPC C36_6.aPE C34_1.PC C38_5.PS C40_3.PS C40_4.aPC C38_4.PS C38_3.PG C30_2.aPC C38_5.PI C40_4.PS C38_2.PS C28_0.aPC C34_0.PE C34_2.PS C36_1.PC C40_4.PG C38_3.aPC C38_2.PA C38_3.PC C38_2.aPC C30_1.PC C38_1.PS C36_5.aPE C28_1.aPE C34_3.PE C36_3.PS C36_5.PI C30_2.aPE C36_0.PG C32_1.aPE C32_2.aPE C40_8.PC C18_0.LPC C32_0.PC C34_0.PS C38_3.PS C40_8.PI C34_2.aPE C36_1.PE C40_2.PS C36_2.PS C30_0.aPC C40_7.aPC C28_2.aPE C40_6.PC C16_0.LPA C20_0.aLPC C24_1.aLPC C20_3.LPC C20_4.LPC C18_2.aLPC C16_1.LPC C32_2.PA C38_7.PG C36_6.PC C18_2.LPC C36_5.PG C38_4.PA C18_1.aLPC C38_6.PG C36_5.PC C18_1.LPC C32_3.PC C34_3.PG ID hibition C. mTOR inhibition B. PI3k inhibition gure 4. Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. AKT, B. PI3K and C. mTOR tor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families, and lipids within family are sorted by name. 1 0.5 0 0.5 1 Neutral Lipids rol 0.3μM 3μM FA MG DG TG CL PS PI PG PA PC PE Neutral Lipids ol 0.3μM 3μM Phospholipids Control 0.3μM 3μM Phospholipids Control 0.3μM 3μM Neutral Lipids Control 0.1μM 0.3μM Phospholipids Control 0.1μM 0.3μM Neutral Lipids Control 0.1μM 0.3μM Phospholipids Control 0.1μM 0.3μM Neutral Lipids Control 0.1μM 1μM Phospholipids Control 0.1μM 1μM Phospholipids Control 0.1μM 1μM Neutral Lipids Control 0.1μM 1μM Neutral Lipids Phospholipids Fold Change PI3k inhibition C32_0.DG C40_0.DG C36_3.aDG C36_4.aDG C36_1.aDG C32_0.aDG C34_0.DG C42_0.DG C32_1.aDG C34_0.aDG C46_2.TG C42_2.TG C44_1.TG C40_1.TG C40_0.TG C42_1.TG C42_0.TG C44_2.TG C46_3.TG C30_0.DG C44_4.TG C46_4.TG C38_0.TG C38_1.TG C50_5.TG C36_0.aDG C44_3.TG C50_4.TG C34_1.DG C42_1.DG C18_1.MG C36_1.DG C40_1.DG C50_6.TG C34_1.aDG C38_1.DG C32_2.aDG C32_1.DG C14_1.FA C14_0.FA C54_7.TG C34_2.DG C16_1.FA C36_0.DG C16_0.FA C34_2.aDG C16_0.MG C36_2.aDG C32_2.DG C38_2.aDG C36_5.aDG C18_0.FA C42_2.DG C38_2.DG C38_4.DG C58_5.TG C40_4.DG C44_2.DG C38_3.DG C58_8.TG C18_0.FaCN C54_6.TG C40_7.DG C44_1.DG C38_5.aDG C40_2.DG C30_1.DG C36_3.DG C20_3.FA C64_3.TG C22_4.FA C62_4.TG C34_3.DG C38_6.DG C56_2.TG C60_0.TG C34_3.aDG C38_6.aDG C18_2.FA C16_0.FaCN C38_5.DG C22_3.FA C40_6.DG C40_5.aDG C30_2.aDG C34_4.aDG C58_7.TG C18_1.FA C62_5.TG C56_8.TG C58_4.TG C40_5.DG C56_5.TG C40_3.DG C36_2.DG C18_0.MG C56_6.TG C40_6.aDG C38_4.aDG C54_5.TG C26_0.FA C20_2.FA C52_1.TG C54_3.TG C58_9.TG C26_1.FA C52_0.TG C24_0.FA C22_2.FA C52_2.TG C58_6.TG C60_2.TG C62_0.TG C24_1.FA C60_4.TG C18_2.MG C54_2.TG C20_4.FA C62_2.TG C22_5.FA C58_1.TG C54_4.TG C62_3.TG C22_1.FA C54_0.TG C50_0.TG C52_3.TG C52_4.TG C60_1.TG C60_3.TG C22_6.FA C54_1.TG C16_1.MG C56_0.TG C56_1.TG C56_3.TG C56_4.TG C62_1.TG C64_2.TG C58_0.TG C58_2.TG C58_3.TG C50_2.TG C56_7.TG C20_1.FA C40_7.aDG C50_1.TG C52_6.TG C48_0.TG C52_5.TG C64_1.TG C30_1.aDG C32_3.aDG C48_3.TG C40_2.TG C46_1.TG C44_0.TG C52_7.TG C48_1.TG C48_2.TG C42_3.TG C46_0.TG C48_4.TG C38_3.aDG C50_3.TG ID C40_7.PS C34_0.aPC C36_3.PA C36_3.PE C40_5.PI C42_5.PC C40_8.PI C32_3.PC C38_6.aPE C40_4.PI C34_2.aPC C36_5.aPC C42_5.PE C38_2.PE C24_0.aLPC C38_7.aPE C36_5.aPE C40_5.PE C40_5.aPE C36_4.PE C44_6.aPE C34_1.PA C34_3.aPC C34_4.aPE C34_2.PA C22_0.aLPC C40_4.aPE C34_3.PE C40_3.PC C42_4.PC C40_7.PI C18_0.LPC C38_5.aPE C38_1.PE C38_6.PE C40_4.PE C30_1.aPC C42_6.PI C36_5.PE C42_7.PI C18_1.LPA C26_0.aPC C36_2.aPE C40_2.PE C32_1.PA C38_3.PE C40_2.PC C42_7.PC C42_6.aPC C38_4.PE C36_3.aPE C38_5.PE C44_5.PC C40_6.PI C14_1.aLPC C40_5.aPC C40_7.aPC C28_0.PC C40_3.PE C36_6.PE C34_1.aPC C42_2.PE C42_4.aPC C42_4.PS C30_1.PI C42_6.PS C38_7.PE C36_4.aPE C16_1.LPC C38_3.PG C72_4.CL C12_0.LPC C36_1.PI C66_5.CL C20_2.LPC C38_2.PG C20_1.LPC C38_4.PG C42_7.aPC C34_1.PS C70_3.CL C34_2.PS C40_6.PG C34_3.PG C74_5.CL C34_3.PI C36_4.PG C30_0.aPE C40_2.PS C38_2.PS C42_7.PA C36_1.PS C38_2.PI C36_2.PI C28_0.aPC C70_5.CL C30_0.PG C74_6.CL C38_5.PS C42_1.PS C36_5.PI C32_1.PI C16_0.LPC C36_2.PS C40_7.PG C66_3.CL C66_4.CL C38_7.PG C18_2.LPC C38_6.PG C36_1.PG C40_5.PG C18_1.LPC C36_2.PG C26_1.LPC C20_3.LPC C34_2.PG C34_0.PS C68_4.CL C34_4.PC C20_4.LPC C38_1.PS C36_3.PG C68_5.CL C70_4.CL C38_2.PA C42_9.PE C68_6.CL C32_2.PI C34_1.PG C40_1.PS C38_5.PG C30_1.PC C40_7.PE C34_1.PC C28_2.aPE C42_5.aPE C30_1.aPE C32_0.PE C42_7.PE C42_8.PE C40_4.PS C38_3.PI C40_7.aPE C34_3.PC C38_7.PC C40_9.aPE C42_8.aPE C42_4.PI C36_4.PI C36_5.PG C28_1.aPE C32_0.PS C40_6.PS C34_2.PC C36_1.PA C22_2.aLPC C28_0.PS C30_0.PS C30_1.PE C32_2.PC C70_6.CL C42_2.PS C70_7.CL C34_2.PI C42_6.PE C34_1.PI C72_5.CL C74_7.CL C40_3.PS C36_4.PS C38_3.PS C40_9.PE C42_5.PS C74_9.CL C44_8.aPE C72_6.CL C32_1.PC C72_8.CL C30_0.PE C72_7.CL C28_0.PE C16_1.aLPC C40_6.PA C38_4.PS C36_3.PI C36_3.PS C74_8.CL C30_1.PS C36_5.PC C32_2.aPC C38_5.PI C40_8.PC C34_1.PE C42_7.aPE C38_4.PA C34_0.PC C28_1.PE C40_5.PA C36_1.PC C20_1.aLPC C38_4.PC C42_4.PE C38_6.PS C32_0.PC C44_7.aPE C38_4.PI C36_2.PC C38_5.PC C36_3.PC C42_6.aPE C36_4.PC C38_6.PC C40_6.aPE C40_8.PE C40_8.aPE C34_0.PI C20_0.aLPC C40_9.PI C30_2.aPC C68_3.CL C34_3.aPE C38_1.PC C40_6.PE C34_4.PE C30_0.PC C34_2.aPE C36_2.PA C40_7.PC C36_1.PE C40_2.PI C32_2.PA C38_3.PC C40_6.PC C18_3.aLPC C40_5.PC C34_2.PE C38_2.PC C40_4.PC C28_1.PC C36_2.PE C42_5.PI C38_3.PA C44_5.aPE C38_6.PI C18_1.aLPC C40_5.PS C18_2.aLPC C40_3.PI C32_0.aPE C34_3.PS C16_2.aLPC C32_2.PE C36_0.PG C30_2.PC C30_1.PG C38_1.PI C24_0.LPC C28_0.LPC C32_1.PE C64_3.CL C14_0.LPC C40_4.PG C32_1.PS C32_2.PG C38_1.PG C64_4.CL C62_3.CL C66_2.CL C32_0.PG C32_1.PG C24_1.LPC C34_0.PG C36_6.aPC C42_6.PA C40_3.PG C32_1.aPE C42_4.aPE C16_0.aLPC C34_0.PE C38_1.aPC C32_0.PI C36_0.PI C32_2.aPE C36_0.PA C38_3.aPC C40_2.aPC C40_1.aPC C38_2.aPC C30_0.PI C44_6.PC C34_0.PA C30_0.aPC C38_0.PI C36_1.aPC C34_1.aPE C36_0.PE C20_0.LPC C40_3.PA C40_3.aPE C36_4.aPC C30_2.aPE C26_0.PA C36_1.aPE C16_0.LPA C40_3.aPC C26_0.PC C32_0.PA C38_3.aPE C36_6.PC C30_0.PA C38_4.aPC C38_4.aPE C40_6.aPC C18_0.LPA C42_1.PE C28_1.PA C36_2.aPC C38_7.aPC C42_3.PE C38_2.aPE C40_0.PS C36_6.aPE C30_1.PA C38_6.aPC C40_4.aPC C38_5.aPC C42_5.aPC C14_0.aLPC C36_3.aPC C28_0.PA C44_7.PC C40_4.PA C32_1.aPC C40_1.PE C42_5.PA C40_8.aPC C42_6.PC C32_0.aPC ID C. C60_1.TG C54_0.TG C64_1.TG C56_3.TG C58_0.TG C62_0.TG C58_1.TG C58_3.TG C50_3.TG C64_2.TG C40_0.TG C42_0.TG C42_1.TG C44_3.TG C54_5.TG C40_1.TG C44_4.TG C46_3.TG C40_0.DG C38_0.TG C40_1.DG C42_1.DG C64_3.TG C50_4.TG C30_0.DG C50_5.TG C54_1.TG C56_1.TG C46_4.TG C50_6.TG C62_4.TG C56_5.TG C56_2.TG C48_1.TG C58_5.TG C58_8.TG C46_0.TG C62_3.TG C56_0.TG C48_2.TG C56_6.TG C50_1.TG C54_6.TG C52_1.TG C58_4.TG C52_5.TG C54_7.TG C48_0.TG C56_8.TG C36_0.aDG C58_2.TG C32_0.DG C56_4.TG C50_2.TG C52_4.TG C54_4.TG C62_5.TG C40_2.TG C58_9.TG C48_4.TG C42_3.TG C52_6.TG C42_2.TG C44_0.TG C56_7.TG C44_1.TG C48_3.TG C52_7.TG C38_1.TG C44_2.TG C58_6.TG C42_0.DG C58_7.TG C46_1.TG C46_2.TG C34_0.DG C50_0.TG C62_1.TG C54_2.TG C60_2.TG C60_4.TG C32_0.aDG C52_3.TG C60_0.TG C60_3.TG C62_2.TG C52_0.TG C34_0.aDG C52_2.TG C32_2.aDG C18_2.MG C34_1.aDG C34_2.aDG C36_0.DG C24_0.FA C38_6.DG C16_0.MG C36_3.aDG C38_1.DG C18_0.MG C36_1.aDG C18_1.MG C36_1.DG C54_3.TG C32_1.aDG C34_3.aDG C30_1.aDG C36_4.aDG C22_2.FA C22_1.FA C40_3.DG C44_1.DG C20_2.FA C20_3.FA C22_3.FA C20_4.FA C34_4.aDG C42_2.DG C18_0.FaCN C20_1.FA C40_7.aDG C22_4.FA C44_2.DG C40_6.DG C30_2.aDG C22_6.FA C40_5.DG C18_0.FA C38_5.DG C22_5.FA C40_2.DG C18_1.FA C26_1.FA C30_1.DG C38_2.DG C32_3.aDG C36_2.DG C18_2.FA C24_1.FA C38_3.DG C38_4.DG C14_1.FA C16_0.FA C32_2.DG C32_1.DG C36_2.aDG C34_1.DG C40_7.DG C26_0.FA C38_6.aDG C38_4.aDG C38_5.aDG C38_3.aDG C36_3.DG C14_0.FA C16_0.FaCN C16_1.FA C34_2.DG C16_1.MG C34_3.DG C40_6.aDG C36_5.aDG C40_4.DG C38_2.aDG C40_5.aDG ID C36_0.PI C14_1.aLPC C16_0.LPA C40_0.PS C38_0.PI C30_1.PA C18_0.LPA C40_3.PA C40_4.PA C34_0.PA C28_0.PA C30_0.PA C32_0.PA C26_0.PC C26_0.PA C32_2.PA C16_2.aLPC C40_5.PE C28_1.PA C36_0.PA C16_0.aLPC C44_6.aPE C40_1.PE C42_1.PE C42_4.PC C36_4.aPC C36_5.aPC C40_3.aPC C28_0.PC C42_6.PC C20_0.LPC C32_0.PI C18_0.LPC C40_4.aPC C36_1.aPE C44_6.PC C36_6.PE C30_0.PI C30_2.aPC C34_1.PA C34_2.PA C38_7.aPC C36_3.PA C44_7.PC C32_1.PA C42_5.PA C36_0.PE C34_0.PC C42_6.PS C20_2.LPC C20_3.LPC C42_9.PE C42_7.PI C14_0.LPC C30_1.PS C20_4.LPC C34_3.PS C38_4.PA C40_8.PI C16_1.LPC C18_3.aLPC C28_1.PE C62_3.CL C42_7.PE C34_4.PC C74_8.CL C18_1.LPC C18_2.LPC C36_4.PS C28_0.PE C40_3.PG C40_4.PG C38_7.PG C38_5.PS C70_5.CL C40_8.PC C40_9.aPE C38_7.PC C40_5.PG C40_9.PI C72_6.CL C34_4.PE C40_7.PG C42_8.PE C40_6.PG C42_6.PA C74_7.CL C30_0.PE C38_3.PS C42_8.aPE C72_7.CL C44_7.aPE C40_7.PE C66_5.CL C32_1.PE C70_3.CL C42_4.PI C74_6.CL C30_2.PC C70_6.CL C20_1.LPC C28_0.LPC C38_6.PG C72_8.CL C42_5.aPE C40_9.PE C72_5.CL C34_1.PE C68_5.CL C30_1.PE C74_9.CL C16_1.aLPC C38_6.PS C70_7.CL C42_6.PE C66_4.CL C38_2.PS C38_1.PG C38_4.PG C40_6.PA C38_5.PG C32_2.PE C34_2.PS C36_5.PI C68_6.CL C38_2.PG C36_1.PS C32_2.PI C40_6.PS C40_7.PS C38_3.PG C70_4.CL C36_2.PA C68_4.CL C34_3.PI C38_4.PS C66_2.CL C34_1.PS C40_4.PS C34_3.PC C36_2.PS C42_6.aPC C12_0.LPC C42_2.PS C66_3.CL C32_0.PE C34_1.PG C36_4.PG C32_1.PS C18_1.aLPC C30_2.aPE C36_4.PI C64_4.CL C34_2.PE C16_0.LPC C42_4.PE C36_6.aPE C38_4.aPC C24_0.aLPC C36_3.aPC C38_3.aPE C30_1.aPC C36_4.aPE C18_1.LPA C38_6.aPC C38_5.aPC C40_5.PA C38_2.aPC C28_1.PC C40_4.PE C38_2.aPE C40_3.PE C38_6.PE C38_4.PE C38_4.aPE C36_2.aPC C68_3.CL C36_6.aPC C42_2.PE C42_5.PI C30_0.PC C42_4.aPC C38_1.aPC C40_7.aPC C34_1.aPE C40_8.aPC C42_6.PI C40_6.aPC C74_5.CL C20_1.aLPC C38_3.aPC C40_5.aPC C40_3.PC C38_3.PE C38_3.PA C40_6.PC C42_3.PE C40_5.PC C38_5.PE C42_5.PS C42_5.PC C32_1.aPC C40_7.PI C36_4.PE C34_0.PI C38_4.PC C38_1.PE C38_1.PC C38_6.PC C22_0.aLPC C30_0.PG C38_2.PE C42_5.PE C26_0.aPC C40_1.aPC C44_5.PC C30_0.aPC C40_2.PC C34_1.aPC C40_2.PE C40_4.PC C36_2.aPE C32_2.aPC C34_2.aPC C40_5.PI C40_4.PI C34_0.PS C40_6.PI C42_7.PC C36_5.aPE C36_5.PE C32_0.PC C38_3.PC C36_1.aPC C36_3.aPE C30_1.PC C32_2.aPE C36_3.PE C40_8.PE C36_6.PC C38_3.PI C40_2.PS C32_1.PI C36_3.PI C24_0.LPC C30_0.aPE C42_7.aPC C36_2.PI C34_0.aPC C36_1.PG C34_2.PC C40_2.aPC C26_1.LPC C40_1.PS C28_1.aPE C42_7.aPE C24_1.LPC C42_4.aPE C34_1.PI C34_1.PC C34_3.PE C34_2.PI C34_3.PG C32_1.PC C34_2.PG C40_7.PC C36_2.PE C40_3.PS C36_3.PG C32_2.PG C36_3.PS C34_0.PG C40_6.aPE C32_2.PC C40_7.aPE C28_2.aPE C38_2.PI C42_6.aPE C38_1.PS C40_8.aPE C40_5.PS C36_2.PG C30_1.PI C36_5.PG C20_0.aLPC C36_0.PG C72_4.CL C34_3.aPC C42_4.PS C32_0.aPC C40_3.aPE C40_3.PI C34_4.aPE C38_5.PC C28_0.aPC C38_7.PE C32_0.PG C38_5.aPE C38_2.PA C32_0.aPE C38_5.PI C32_0.PS C14_0.aLPC C64_3.CL C30_1.PG C42_5.aPC C36_1.PI C34_2.aPE C38_6.aPE C36_5.PC C36_1.PC C32_1.aPE C44_8.aPE C40_2.PI C36_3.PC C38_2.PC C22_2.aLPC C38_7.aPE C40_5.aPE C30_0.PS C34_3.aPE C36_1.PA C38_6.PI C36_4.PC C42_7.PA C32_3.PC C32_1.PG C28_0.PS C38_1.PI C44_5.aPE C42_1.PS C38_4.PI C34_0.PE C36_1.PE C40_6.PE C40_4.aPE C30_1.aPE C36_2.PC C18_2.aLPC ID C38_1.TG C30_2.aDG C38_3.aDG C40_5.aDG C18_0.FaCN C32_1.aDG C36_5.aDG C18_0.FA C38_5.aDG C38_4.aDG C40_7.aDG C32_2.aDG C14_1.FA C38_6.aDG C16_0.FA C34_2.DG C34_3.DG C30_1.DG C38_4.DG C40_6.aDG C32_1.DG C32_0.aDG C32_2.DG C36_2.aDG C14_0.FA C16_1.FA C36_4.DG C38_0.TG C34_3.aDG C36_4.aDG C30_1.aDG C34_1.aDG C34_2.aDG C36_3.aDG C18_1.FA C36_1.aDG C16_0.FaCN C18_2.FA C38_2.aDG C40_2.TG C32_3.aDG C38_3.DG C24_1.FA C36_0.aDG C38_2.DG C40_3.DG C16_0.MG C36_1.DG C34_0.aDG C20_4.FA C18_0.MG C26_0.FA C32_0.DG C36_2.DG C18_2.MG C42_3.TG C34_1.DG C38_5.DG C16_1.MG C24_0.FA C36_3.DG C34_4.aDG C30_0.DG C56_8.TG C52_5.TG C54_7.TG C56_7.TG C58_7.TG C58_8.TG C48_3.TG C50_4.TG C52_7.TG C56_4.TG C52_4.TG C54_5.TG C56_5.TG C58_6.TG C50_5.TG C58_5.TG C20_2.FA C56_6.TG C58_4.TG C54_6.TG C50_3.TG C52_6.TG C50_6.TG C58_9.TG C20_1.FA C62_0.TG C22_5.FA C38_6.DG C40_1.DG C38_1.DG C40_2.DG C26_1.FA C36_0.DG C40_1.TG C40_0.DG C52_0.TG C40_5.DG C22_4.FA C42_0.DG C22_2.FA C42_1.DG C20_3.FA C58_0.TG C40_4.DG C44_4.TG C42_2.DG C42_0.TG C48_0.TG C60_0.TG C40_0.TG C56_0.TG C50_0.TG C44_1.DG C34_0.DG C42_1.TG C44_2.DG C60_2.TG C56_1.TG C60_1.TG C22_1.FA C46_0.TG C44_1.TG C58_1.TG C40_6.DG C46_3.TG C52_1.TG C62_1.TG C62_5.TG C62_3.TG C22_6.FA C44_3.TG C62_2.TG C54_1.TG C62_4.TG C50_1.TG C48_1.TG C58_2.TG C42_2.TG C44_0.TG C46_1.TG C60_4.TG C54_0.TG C52_3.TG C64_1.TG C54_2.TG C52_2.TG C56_2.TG C60_3.TG C58_3.TG C48_4.TG C56_3.TG C46_2.TG C50_2.TG C46_4.TG C18_1.MG C64_2.TG C40_7.DG C64_3.TG C44_2.TG C54_4.TG C22_3.FA C48_2.TG C54_3.TG ID C28_1.PA C30_2.aPC C36_0.aPC C72_4.CL C44_8.aPE C46_9.aPE C46_8.aPE C36_5.aPC C40_9.PI C38_7.aPC C40_8.aPC C28_1.PE C42_7.aPC C40_6.aPE C30_1.aPC C42_1.PE C36_6.aPC C36_1.aPE C40_8.PI C38_0.PI C42_7.PC C40_5.aPE C18_0.LPC C14_1.aLPC C16_1.aLPC C38_6.aPC C40_3.aPE C18_2.aLPC C36_1.PC C38_6.PC C70_3.CL C42_4.PC C26_0.PC C70_4.CL C40_8.PC C40_6.PE C74_8.CL C40_1.PE C40_5.aPC C40_3.PC C42_5.PS C40_7.PC C46_5.aPE C40_2.PC C40_7.aPC C44_5.PC C40_6.PC C38_6.aPE C40_4.PI C40_6.PI C26_0.aPC C40_5.PC C42_6.aPC C40_3.PE C40_5.PI C38_1.PG C42_6.PE C42_8.PE C42_5.PI C42_5.PC C40_4.PE C38_4.aPE C44_7.PC C40_1.aPC C16_2.aLPC C42_6.PC C72_7.CL C40_6.aPC C40_4.PC C40_3.PI C38_2.PC C36_4.aPE C38_3.aPE C40_4.aPE C40_6.PS C42_6.PI C42_7.aPE C46_7.aPE 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C36_3.aPE C38_6.PS C20_1.LPC C40_6.PS C74_9.CL C40_5.PI C40_3.PC C70_6.CL C38_2.PE C38_7.PE C36_4.aPE C32_0.PE C38_2.aPE C34_1.PE C74_7.CL C74_5.CL C30_1.PS C44_8.aPE C68_5.CL C34_0.PI C40_9.aPE C40_1.PS C42_7.PC C36_3.PE C46_7.aPE C40_2.PC C16_2.aLPC C42_5.PS C36_3.PI C36_1.PG C38_6.aPE C36_3.PA C70_7.CL C36_4.PI C42_5.PA C40_7.PC C40_5.PS C32_0.PS C38_2.PG C40_3.PG C32_2.PI C36_2.PA C40_4.PC C16_0.aLPC C42_5.aPC C32_2.PE C42_4.PS C40_6.aPC C34_1.PS C34_3.aPE C38_3.PI C34_0.PC C40_3.aPC C38_2.PC C30_1.aPC C26_1.aLPC C34_4.PE C28_0.PS C30_0.PS C40_5.aPC C40_7.PS C34_2.PE C36_2.PE C74_6.CL C32_1.PS C40_8.aPC C36_2.aPE C34_2.PI C38_1.PE C36_2.PI C40_5.PC C34_1.aPE C34_1.PG C34_4.aPE C70_4.CL C38_1.PI C40_3.aPE C30_0.PA C36_6.PE C72_4.CL C72_8.CL C44_5.PC C66_5.CL C42_1.PE C30_0.PG C32_1.PI C64_4.CL C28_1.PC C40_6.aPE C30_1.PE C28_0.PE C42_3.PE C42_5.PI C68_6.CL C40_1.aPC C66_3.CL C42_4.aPC C42_2.PE C42_6.aPE C44_6.PC C34_0.aPC C28_0.PC C64_3.CL C42_5.aPE C42_6.PS C40_4.aPE C40_5.aPE C38_6.PE C40_5.PE C38_3.aPE C46_5.aPE C46_9.aPE C72_7.CL C38_4.aPE C30_1.PI C32_1.PG C40_4.PA C42_7.aPC C36_4.PE C38_2.PI C34_1.PI C46_6.aPE C38_1.PC C44_5.aPE C36_0.PI C40_4.PE C34_1.PA C66_4.CL C40_7.aPE C18_3.aLPC C36_1.aPE C38_7.aPE C38_6.PI C40_3.PE C42_7.aPE C38_4.PE C30_0.PC C38_5.aPE C42_2.PS C42_7.PI C72_5.CL C30_0.PE C32_0.aPE C14_1.aLPC C36_5.PE C32_0.PG C40_1.PE C42_1.PS C40_8.aPE C40_6.PI C40_3.PI C44_7.PC C40_4.PI C40_7.PI C42_4.PC C46_8.aPE C42_6.PC C36_1.PI C42_6.aPC C38_0.PI C74_8.CL C30_0.aPE C38_5.PE C44_6.aPE C38_3.PE C42_8.aPE C26_0.aPC C72_6.CL C44_7.aPE C42_5.PC C68_4.CL C32_1.PE C38_1.PG C16_1.aLPC C22_0.aLPC C40_3.PA C40_2.aPC C24_0.aLPC C20_1.aLPC C40_8.PE C42_9.PE C66_2.CL C26_0.PC C40_7.PE C24_1.LPC C42_6.PE C42_4.PE C30_1.PG C26_1.LPC C42_5.PE C40_2.PI C40_6.PE C70_3.CL C42_7.PE C42_8.PE C32_0.PI C42_6.PI C32_1.PA C62_3.CL C24_0.LPC C34_0.PA C32_0.PA C30_0.PI C42_4.PI C20_0.LPC C42_4.aPE C18_1.LPA C32_2.PC C36_4.PG C40_6.PA C36_4.PC C38_4.PI C42_6.PA C38_5.PG C42_7.PA C38_5.PC C38_7.PC C36_4.aPC C34_3.PI C36_3.PG C40_7.PG C38_5.aPC C12_0.LPC C14_0.aLPC C34_3.PC C34_4.PC C36_5.aPC C38_6.aPC C40_5.PA C38_4.aPC C36_4.PS C40_6.PG C34_2.aPC C38_1.aPC C30_2.PC C36_2.aPC C34_3.PS C34_2.PG C34_2.PC C32_1.aPC C32_0.aPC C32_2.aPC C38_4.PC C38_4.PG C34_3.aPC C36_2.PG C38_6.PC C36_1.aPC C36_1.PA C36_3.aPC C36_3.PC C38_7.aPC C36_0.PE C34_2.PA C32_1.PC C32_2.PG C16_0.LPC C36_2.PC C14_0.LPC C40_5.PG C36_1.PS C34_0.PG C20_2.LPC C36_6.aPE C34_1.PC C38_5.PS C40_3.PS C40_4.aPC C38_4.PS C38_3.PG C30_2.aPC C38_5.PI C40_4.PS C38_2.PS C28_0.aPC C34_0.PE C34_2.PS C36_1.PC C40_4.PG C38_3.aPC C38_2.PA C38_3.PC C38_2.aPC C30_1.PC C38_1.PS C36_5.aPE C28_1.aPE C34_3.PE C36_3.PS C36_5.PI C30_2.aPE C36_0.PG C32_1.aPE C32_2.aPE C40_8.PC C18_0.LPC C32_0.PC C34_0.PS C38_3.PS C40_8.PI C34_2.aPE C36_1.PE C40_2.PS C36_2.PS C30_0.aPC C40_7.aPC C28_2.aPE C40_6.PC C16_0.LPA C20_0.aLPC C24_1.aLPC C20_3.LPC C20_4.LPC C18_2.aLPC C16_1.LPC C32_2.PA C38_7.PG C36_6.PC C18_2.LPC C36_5.PG C38_4.PA C18_1.aLPC C38_6.PG C36_5.PC C18_1.LPC C32_3.PC C34_3.PG ID hibition C. mTOR inhibition B. PI3k inhibition gure 4. Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. AKT, B. PI3K and C. mTOR tor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families, and lipids within family are sorted by name. 1 0.5 0 0.5 1 Neutral Lipids rol 0.3μM 3μM FA MG DG TG CL PS PI PG PA PC PE Neutral Lipids ol 0.3μM 3μM Phospholipids Control 0.3μM 3μM Phospholipids Control 0.3μM 3μM Neutral Lipids Control 0.1μM 0.3μM Phospholipids Control 0.1μM 0.3μM Neutral Lipids Control 0.1μM 0.3μM Phospholipids Control 0.1μM 0.3μM Neutral Lipids Control 0.1μM 1μM Phospholipids Control 0.1μM 1μM Phospholipids Control 0.1μM 1μM Neutral Lipids Control 0.1μM 1μM Neutral Lipids Phospholipids Fold Change mTOR inhibition FA MG DG TG CL PS PI PG PA PC PE Neutral Lipids Control 0.1μM 1μM Phospholipids Control 0.1μM 1μM Neutral Lipids Phospholipids C40_7.PS C34_0.aPC C36_3.PA C36_3.PE C40_5.PI C42_5.PC C40_8.PI C32_3.PC C38_6.aPE C40_4.PI C34_2.aPC C36_5.aPC C42_5.PE C38_2.PE C24_0.aLPC C38_7.aPE C36_5.aPE C40_5.PE C40_5.aPE C36_4.PE C44_6.aPE C34_1.PA C34_3.aPC C34_4.aPE C34_2.PA C22_0.aLPC C40_4.aPE C34_3.PE C40_3.PC C42_4.PC C40_7.PI C18_0.LPC C38_5.aPE C38_1.PE C38_6.PE C40_4.PE C30_1.aPC C42_6.PI C36_5.PE C42_7.PI C18_1.LPA C26_0.aPC C36_2.aPE C40_2.PE C32_1.PA C38_3.PE C40_2.PC C42_7.PC C42_6.aPC C38_4.PE C36_3.aPE C38_5.PE C44_5.PC C40_6.PI C14_1.aLPC C40_5.aPC C40_7.aPC C28_0.PC C40_3.PE C36_6.PE C34_1.aPC C42_2.PE C42_4.aPC C42_4.PS C30_1.PI C42_6.PS C38_7.PE C36_4.aPE C16_1.LPC C38_3.PG C72_4.CL C12_0.LPC C36_1.PI C66_5.CL C20_2.LPC C38_2.PG C20_1.LPC C38_4.PG C42_7.aPC C34_1.PS C70_3.CL C34_2.PS C40_6.PG C34_3.PG C74_5.CL C34_3.PI C36_4.PG C30_0.aPE C40_2.PS C38_2.PS C42_7.PA C36_1.PS C38_2.PI C36_2.PI C28_0.aPC C70_5.CL C30_0.PG C74_6.CL C38_5.PS C42_1.PS C36_5.PI C32_1.PI C16_0.LPC C36_2.PS C40_7.PG C66_3.CL C66_4.CL C38_7.PG C18_2.LPC C38_6.PG C36_1.PG C40_5.PG C18_1.LPC C36_2.PG C26_1.LPC C20_3.LPC C34_2.PG C34_0.PS C68_4.CL C34_4.PC C20_4.LPC C38_1.PS C36_3.PG C68_5.CL C70_4.CL C38_2.PA C42_9.PE C68_6.CL C32_2.PI C34_1.PG C40_1.PS C38_5.PG C30_1.PC C40_7.PE C34_1.PC C28_2.aPE C42_5.aPE C30_1.aPE C32_0.PE C42_7.PE C42_8.PE C40_4.PS C38_3.PI C40_7.aPE C34_3.PC C38_7.PC C40_9.aPE C42_8.aPE C42_4.PI C36_4.PI C36_5.PG C28_1.aPE C32_0.PS C40_6.PS C34_2.PC C36_1.PA C22_2.aLPC C28_0.PS C30_0.PS C30_1.PE C32_2.PC C70_6.CL C42_2.PS C70_7.CL C34_2.PI C42_6.PE C34_1.PI C72_5.CL C74_7.CL C40_3.PS C36_4.PS C38_3.PS C40_9.PE C42_5.PS C74_9.CL C44_8.aPE C72_6.CL C32_1.PC C72_8.CL C30_0.PE C72_7.CL C28_0.PE C16_1.aLPC C40_6.PA C38_4.PS C36_3.PI C36_3.PS C74_8.CL C30_1.PS C36_5.PC C32_2.aPC C38_5.PI C40_8.PC C34_1.PE C42_7.aPE C38_4.PA C34_0.PC C28_1.PE C40_5.PA C36_1.PC C20_1.aLPC C38_4.PC C42_4.PE C38_6.PS C32_0.PC C44_7.aPE C38_4.PI C36_2.PC C38_5.PC C36_3.PC C42_6.aPE C36_4.PC C38_6.PC C40_6.aPE C40_8.PE C40_8.aPE C34_0.PI C20_0.aLPC C40_9.PI C30_2.aPC C68_3.CL C34_3.aPE C38_1.PC C40_6.PE C34_4.PE C30_0.PC C34_2.aPE C36_2.PA C40_7.PC C36_1.PE C40_2.PI C32_2.PA C38_3.PC C40_6.PC C18_3.aLPC C40_5.PC C34_2.PE C38_2.PC C40_4.PC C28_1.PC C36_2.PE C42_5.PI C38_3.PA C44_5.aPE C38_6.PI C18_1.aLPC C40_5.PS C18_2.aLPC C40_3.PI C32_0.aPE C34_3.PS C16_2.aLPC C32_2.PE C36_0.PG C30_2.PC C30_1.PG C38_1.PI C24_0.LPC C28_0.LPC C32_1.PE C64_3.CL C14_0.LPC C40_4.PG C32_1.PS C32_2.PG C38_1.PG C64_4.CL C62_3.CL C66_2.CL C32_0.PG C32_1.PG C24_1.LPC C34_0.PG C36_6.aPC C42_6.PA C40_3.PG C32_1.aPE C42_4.aPE C16_0.aLPC C34_0.PE C38_1.aPC C32_0.PI C36_0.PI C32_2.aPE C36_0.PA C38_3.aPC C40_2.aPC C40_1.aPC C38_2.aPC C30_0.PI C44_6.PC C34_0.PA C30_0.aPC C38_0.PI C36_1.aPC C34_1.aPE C36_0.PE C20_0.LPC C40_3.PA C40_3.aPE C36_4.aPC C30_2.aPE C26_0.PA C36_1.aPE C16_0.LPA C40_3.aPC C26_0.PC C32_0.PA C38_3.aPE C36_6.PC C30_0.PA C38_4.aPC C38_4.aPE C40_6.aPC C18_0.LPA C42_1.PE C28_1.PA C36_2.aPC C38_7.aPC C42_3.PE C38_2.aPE C40_0.PS C36_6.aPE C30_1.PA C38_6.aPC C40_4.aPC C38_5.aPC C42_5.aPC C14_0.aLPC C36_3.aPC C28_0.PA C44_7.PC C40_4.PA C32_1.aPC C40_1.PE C42_5.PA C40_8.aPC C42_6.PC C32_0.aPC ID FA MG DG TG CL PS PI PG PA PC PE Phospholipids Control 0.1μM 1μM Neutral Lipids Phospholipids C36_1.PA C70_4.CL C28_2.aPE C44_5.aPE C36_4.PS C40_6.PI C36_2.PE C36_3.PS C68_5.CL C40_6.PA C42_1.PS C36_5.PI C34_4.aPE C30_1.PC C68_4.CL C36_1.PG C34_2.PS C38_4.PA C40_5.aPE C42_6.PA C38_3.PG C38_3.PI C74_7.CL C74_9.CL C38_2.PS C34_3.PI C38_5.aPE C38_6.PG C38_7.PC C36_3.PI C34_3.PG C72_6.CL C38_1.PS C38_4.PG C40_3.PS C36_1.PS C72_5.CL C36_2.PI C72_7.CL C40_1.PS C74_6.CL C68_6.CL C40_7.PS C34_2.PI C70_6.CL C72_8.CL C36_4.PG C36_2.PS C42_2.PS C40_9.PI C36_4.PI C28_0.PS C30_0.PS C40_9.PE C42_7.PC C28_1.aPE C70_7.CL C74_5.CL C38_3.PS C36_5.PG C38_2.PG C36_2.PA C34_2.PG C34_2.aPE C70_5.CL C38_6.PI C38_4.PS C72_4.CL C40_4.PC C20_3.LPC C44_6.aPE C38_3.PC C38_4.PC C20_4.LPC C18_2.LPC C20_2.LPC C40_7.PI C38_6.PC C40_9.aPE C36_3.PC C32_1.PC C42_8.aPE C36_4.PC C36_2.PC C40_7.aPE C34_2.PC C40_8.aPE C34_1.PC C40_5.PC C18_1.LPC C12_0.LPC C42_8.PE C44_8.aPE C32_2.PC C42_6.aPE C42_9.PE C38_5.PC C42_7.aPE C16_1.LPC C38_7.PG C40_6.aPE C40_7.PG C40_8.PE C42_7.PE C38_7.aPE C40_6.PC C42_5.aPE C34_3.PC C40_7.PC C74_8.CL C36_5.PC C36_3.PG C20_1.aLPC C42_7.PA C40_2.PS C36_2.PG C32_0.PS C38_5.PG C38_6.aPE C36_1.PC C38_2.PC C40_5.PG C40_8.PC C38_5.PI C40_6.PG C40_4.PG C36_6.aPE C38_4.PI C44_7.aPE C40_7.PE C34_0.PS C36_5.aPE C40_8.PI C40_3.PG C30_2.PC C32_0.PC C32_3.PC C28_0.PA C16_0.LPA C34_0.aPC C36_0.PE C26_0.PA C40_4.PA C34_0.PC C30_2.aPC C38_1.aPC C36_0.PA C28_0.aPC C18_2.aLPC C28_1.PA C40_3.PA C18_0.LPA C42_4.PC C16_2.aLPC C36_5.aPC C40_3.aPC C20_0.aLPC C42_4.aPC C40_3.PC C22_0.aLPC C34_3.PS C42_5.aPC C16_1.aLPC C42_6.aPC C14_1.aLPC C34_3.aPE C66_2.CL C38_2.PI C70_3.CL C42_7.aPC C42_5.PS C38_5.PS C40_4.PS C32_2.PI C40_5.PI C66_4.CL C40_6.PS C66_5.CL C42_4.PE C40_4.aPE C30_1.PS C34_1.PG C40_6.PE C42_4.aPE C32_2.aPE C40_3.PI C42_5.PI C66_3.CL C68_3.CL C30_0.PE C40_2.aPC C40_3.aPE C30_1.PE C30_1.PI C42_7.PI C40_2.PI C40_5.PA C34_4.PC C30_2.aPE C32_1.PI C32_0.PE C38_3.PA C34_1.PS C34_1.PI C38_2.PA C32_2.PG C42_6.PE C30_1.aPE C32_1.PG C34_3.aPC C34_1.PA C44_6.PC C42_4.PI C34_2.aPC C42_5.PE C32_0.aPE C38_1.PC C38_2.PE C24_0.LPC C62_3.CL C30_0.aPE C26_0.PC C38_1.PI C26_1.LPC C36_3.aPE C40_4.PE C34_1.aPC C34_3.PE C20_1.LPC C34_1.PE C34_2.PE C34_4.PE C16_0.LPC C32_1.PE C26_0.aPC C36_3.PA C38_5.PE C42_6.PI C32_1.PS C32_2.PA C36_1.PE C40_3.PE C34_0.PG C64_4.CL C28_0.PC C38_4.aPE C30_0.PC C32_2.PE C34_0.PE C24_1.LPC C30_0.PG C28_1.PC C36_3.PE C32_0.PG C14_0.LPC C38_7.PE C36_1.PI C40_5.PE C40_5.PS C38_6.PE C36_0.PG C28_0.PE C36_6.PC C64_3.CL C40_4.PI C38_1.PG C44_7.PC C24_0.aLPC C30_0.PA C32_0.PA C30_0.aPC C40_4.aPC C18_1.aLPC C34_0.PA C32_0.aPC C32_2.aPC C44_5.PC C38_0.PI C38_3.aPC C34_1.aPE C42_4.PS C40_2.PC C38_2.aPE C40_1.PE C36_1.aPE C42_6.PS C36_4.aPC C40_2.PE C36_6.PE C34_2.PA C42_6.PC C28_1.PE C40_1.aPC C20_0.LPC C28_0.LPC C36_2.aPE C42_1.PE C30_1.PG C42_3.PE C32_1.PA C32_0.PI C32_1.aPC C40_8.aPC C34_0.PI C40_0.PS C36_4.PE C42_5.PA C38_4.PE C42_5.PC C38_6.PS C38_4.aPC C40_5.aPC C30_1.PA C36_6.aPC C38_5.aPC C38_3.PE C38_2.aPC C18_1.LPA C40_6.aPC C32_1.aPE C40_7.aPC C30_1.aPC C16_0.aLPC C36_2.aPC C38_1.PE C38_3.aPE C38_6.aPC C18_0.LPC C30_0.PI C38_7.aPC C36_1.aPC C36_5.PE C36_4.aPE C36_0.PI C36_3.aPC C42_2.PE ID Phospholipids Control 0.1μM 0.3μM C36_0.PI C14_1.aLPC C16_0.LPA C40_0.PS C38_0.PI C30_1.PA C18_0.LPA C40_3.PA C40_4.PA C34_0.PA C28_0.PA C30_0.PA C32_0.PA C26_0.PC C26_0.PA C32_2.PA C16_2.aLPC C40_5.PE C28_1.PA C36_0.PA C16_0.aLPC C44_6.aPE C40_1.PE C42_1.PE C42_4.PC C36_4.aPC C36_5.aPC C40_3.aPC C28_0.PC C42_6.PC C20_0.LPC C32_0.PI C18_0.LPC C40_4.aPC C36_1.aPE C44_6.PC C36_6.PE C30_0.PI C30_2.aPC C34_1.PA C34_2.PA C38_7.aPC C36_3.PA C44_7.PC C32_1.PA C42_5.PA C36_0.PE C34_0.PC C42_6.PS C20_2.LPC C20_3.LPC C42_9.PE C42_7.PI C14_0.LPC C30_1.PS C20_4.LPC C34_3.PS C38_4.PA C40_8.PI C16_1.LPC C18_3.aLPC C28_1.PE C62_3.CL C42_7.PE C34_4.PC C74_8.CL C18_1.LPC C18_2.LPC C36_4.PS C28_0.PE C40_3.PG C40_4.PG C38_7.PG C38_5.PS C70_5.CL C40_8.PC C40_9.aPE C38_7.PC C40_5.PG C40_9.PI C72_6.CL C34_4.PE C40_7.PG C42_8.PE C40_6.PG C42_6.PA C74_7.CL C30_0.PE C38_3.PS C42_8.aPE C72_7.CL C44_7.aPE C40_7.PE C66_5.CL C32_1.PE C70_3.CL C42_4.PI C74_6.CL C30_2.PC C70_6.CL C20_1.LPC C28_0.LPC C38_6.PG C72_8.CL C42_5.aPE C40_9.PE C72_5.CL C34_1.PE C68_5.CL C30_1.PE C74_9.CL C16_1.aLPC C38_6.PS C70_7.CL C42_6.PE C66_4.CL C38_2.PS C38_1.PG C38_4.PG C40_6.PA C38_5.PG C32_2.PE C34_2.PS C36_5.PI C68_6.CL C38_2.PG C36_1.PS C32_2.PI C40_6.PS C40_7.PS C38_3.PG C70_4.CL C36_2.PA C68_4.CL C34_3.PI C38_4.PS C66_2.CL C34_1.PS C40_4.PS C34_3.PC C36_2.PS C42_6.aPC C12_0.LPC C42_2.PS C66_3.CL C32_0.PE C34_1.PG C36_4.PG C32_1.PS C18_1.aLPC C30_2.aPE C36_4.PI C64_4.CL C34_2.PE C16_0.LPC C42_4.PE C36_6.aPE C38_4.aPC C24_0.aLPC C36_3.aPC C38_3.aPE C30_1.aPC C36_4.aPE C18_1.LPA C38_6.aPC C38_5.aPC C40_5.PA C38_2.aPC C28_1.PC C40_4.PE C38_2.aPE C40_3.PE C38_6.PE C38_4.PE C38_4.aPE C36_2.aPC C68_3.CL C36_6.aPC C42_2.PE C42_5.PI C30_0.PC C42_4.aPC C38_1.aPC C40_7.aPC C34_1.aPE C40_8.aPC C42_6.PI C40_6.aPC C74_5.CL C20_1.aLPC C38_3.aPC C40_5.aPC C40_3.PC C38_3.PE C38_3.PA C40_6.PC C42_3.PE C40_5.PC C38_5.PE C42_5.PS C42_5.PC C32_1.aPC C40_7.PI C36_4.PE C34_0.PI C38_4.PC C38_1.PE C38_1.PC C38_6.PC C22_0.aLPC C30_0.PG C38_2.PE C42_5.PE C26_0.aPC C40_1.aPC C44_5.PC C30_0.aPC C40_2.PC C34_1.aPC C40_2.PE C40_4.PC C36_2.aPE C32_2.aPC C34_2.aPC C40_5.PI C40_4.PI C34_0.PS C40_6.PI C42_7.PC C36_5.aPE C36_5.PE C32_0.PC C38_3.PC C36_1.aPC C36_3.aPE C30_1.PC C32_2.aPE C36_3.PE C40_8.PE C36_6.PC C38_3.PI C40_2.PS C32_1.PI C36_3.PI C24_0.LPC C30_0.aPE C42_7.aPC C36_2.PI C34_0.aPC C36_1.PG C34_2.PC C40_2.aPC C26_1.LPC C40_1.PS C28_1.aPE C42_7.aPE C24_1.LPC C42_4.aPE C34_1.PI C34_1.PC C34_3.PE C34_2.PI C34_3.PG C32_1.PC C34_2.PG C40_7.PC C36_2.PE C40_3.PS C36_3.PG C32_2.PG C36_3.PS C34_0.PG C40_6.aPE C32_2.PC C40_7.aPE C28_2.aPE C38_2.PI C42_6.aPE C38_1.PS C40_8.aPE C40_5.PS C36_2.PG C30_1.PI C36_5.PG C20_0.aLPC C36_0.PG C72_4.CL C34_3.aPC C42_4.PS C32_0.aPC C40_3.aPE C40_3.PI C34_4.aPE C38_5.PC C28_0.aPC C38_7.PE C32_0.PG C38_5.aPE C38_2.PA C32_0.aPE C38_5.PI C32_0.PS C14_0.aLPC C64_3.CL C30_1.PG C42_5.aPC C36_1.PI C34_2.aPE C38_6.aPE C36_5.PC C36_1.PC C32_1.aPE C44_8.aPE C40_2.PI C36_3.PC C38_2.PC C22_2.aLPC C38_7.aPE C40_5.aPE C30_0.PS C34_3.aPE C36_1.PA C38_6.PI C36_4.PC C42_7.PA C32_3.PC C32_1.PG C28_0.PS C38_1.PI C44_5.aPE C42_1.PS C38_4.PI C34_0.PE C36_1.PE C40_6.PE C40_4.aPE C30_1.aPE C36_2.PC C18_2.aLPC ID Phospholipids Control 0.3μM 3μM C44_3.TG C64_2.TG C46_4.TG C48_4.TG C44_2.TG C44_4.TG C52_7.TG C46_2.TG C50_5.TG C50_6.TG C64_1.TG C46_3.TG C52_6.TG C40_1.TG C44_1.TG C42_1.TG C42_2.TG C62_0.TG C38_0.TG C40_2.TG C38_1.TG C42_3.TG C52_1.TG C34_0.DG C48_1.TG C54_1.TG C50_1.TG C52_0.TG C40_0.TG C36_0.DG C62_2.TG C42_0.TG C46_1.TG C62_1.TG C42_1.DG C38_1.DG C50_0.TG C34_0.aDG C48_0.TG C58_1.TG C54_0.TG C36_1.aDG C58_0.TG C60_0.TG C30_0.DG C46_0.TG C36_0.aDG C56_1.TG C60_2.TG C42_0.DG C44_0.TG C40_0.DG C32_0.DG C60_1.TG C32_0.aDG C56_0.TG C34_1.aDG C40_1.DG C30_1.aDG C32_1.aDG C36_4.aDG C44_1.DG C36_3.aDG C32_2.aDG C36_2.aDG C36_1.DG C38_4.aDG C34_2.aDG C34_3.aDG C38_3.aDG C40_4.DG C32_1.DG C34_1.DG C26_0.FA C40_6.DG C24_0.FA C38_6.DG C40_5.DG C38_5.aDG C44_2.DG C38_2.aDG C30_1.DG C14_0.FA C38_6.aDG C26_1.FA C38_2.DG C40_6.aDG C62_5.TG C40_3.DG C24_1.FA C40_7.aDG C34_2.DG C38_3.DG C16_1.FA C38_5.DG C36_5.aDG C16_0.FA C40_2.DG C14_1.FA C18_0.FaCN C18_2.MG C32_2.DG C42_2.DG C20_4.FA C22_2.FA C18_0.FA C22_3.FA C22_6.FA C36_2.DG C34_3.DG C36_3.DG C40_7.DG C40_5.aDG C18_1.MG C18_1.FA C18_2.FA C22_4.FA C22_5.FA C16_0.FaCN C20_1.FA C38_4.DG C52_2.TG C54_2.TG C56_3.TG C58_3.TG C16_0.MG C52_3.TG C32_3.aDG C60_3.TG C34_4.aDG C54_3.TG C16_1.MG C22_1.FA C20_2.FA C20_3.FA C30_2.aDG C50_2.TG C58_4.TG C50_3.TG C54_4.TG C56_4.TG C48_2.TG C60_4.TG C56_5.TG C58_8.TG C52_4.TG C56_2.TG C58_5.TG C58_7.TG C62_3.TG C54_5.TG C56_8.TG C62_4.TG C48_3.TG C58_9.TG C54_7.TG C50_4.TG C64_3.TG C56_7.TG C52_5.TG C54_6.TG C56_6.TG C58_6.TG C18_0.MG C58_2.TG IDi Neutral Lipids Control 0.1μM 0.3μM C32_0.DG C40_0.DG C36_3.aDG C36_4.aDG C36_1.aDG C32_0.aDG C34_0.DG C42_0.DG C32_1.aDG C34_0.aDG C46_2.TG C42_2.TG C44_1.TG C40_1.TG C40_0.TG C42_1.TG C42_0.TG C44_2.TG C46_3.TG C30_0.DG C44_4.TG C46_4.TG C38_0.TG C38_1.TG C50_5.TG C36_0.aDG C44_3.TG C50_4.TG C34_1.DG C42_1.DG C18_1.MG C36_1.DG C40_1.DG C50_6.TG C34_1.aDG C38_1.DG C32_2.aDG C32_1.DG C14_1.FA C14_0.FA C54_7.TG C34_2.DG C16_1.FA C36_0.DG C16_0.FA C34_2.aDG C16_0.MG C36_2.aDG C32_2.DG C38_2.aDG C36_5.aDG C18_0.FA C42_2.DG C38_2.DG C38_4.DG C58_5.TG C40_4.DG C44_2.DG C38_3.DG C58_8.TG C18_0.FaCN C54_6.TG C40_7.DG C44_1.DG C38_5.aDG C40_2.DG C30_1.DG C36_3.DG C20_3.FA C64_3.TG C22_4.FA C62_4.TG C34_3.DG C38_6.DG C56_2.TG C60_0.TG C34_3.aDG C38_6.aDG C18_2.FA C16_0.FaCN C38_5.DG C22_3.FA C40_6.DG C40_5.aDG C30_2.aDG C34_4.aDG C58_7.TG C18_1.FA C62_5.TG C56_8.TG C58_4.TG C40_5.DG C56_5.TG C40_3.DG C36_2.DG C18_0.MG C56_6.TG C40_6.aDG C38_4.aDG C54_5.TG C26_0.FA C20_2.FA C52_1.TG C54_3.TG C58_9.TG C26_1.FA C52_0.TG C24_0.FA C22_2.FA C52_2.TG C58_6.TG C60_2.TG C62_0.TG C24_1.FA C60_4.TG C18_2.MG C54_2.TG C20_4.FA C62_2.TG C22_5.FA C58_1.TG C54_4.TG C62_3.TG C22_1.FA C54_0.TG C50_0.TG C52_3.TG C52_4.TG C60_1.TG C60_3.TG C22_6.FA C54_1.TG C16_1.MG C56_0.TG C56_1.TG C56_3.TG C56_4.TG C62_1.TG C64_2.TG C58_0.TG C58_2.TG C58_3.TG C50_2.TG C56_7.TG C20_1.FA C40_7.aDG C50_1.TG C52_6.TG C48_0.TG C52_5.TG C64_1.TG C30_1.aDG C32_3.aDG C48_3.TG C40_2.TG C46_1.TG C44_0.TG C52_7.TG C48_1.TG C48_2.TG C42_3.TG C46_0.TG C48_4.TG C38_3.aDG C50_3.TG ID Neutral Lipids Control 0.1μM 1μM C60_1.TG C54_0.TG C64_1.TG C56_3.TG C58_0.TG C62_0.TG C58_1.TG C58_3.TG C50_3.TG C64_2.TG C40_0.TG C42_0.TG C42_1.TG C44_3.TG C54_5.TG C40_1.TG C44_4.TG C46_3.TG C40_0.DG C38_0.TG C40_1.DG C42_1.DG C64_3.TG C50_4.TG C30_0.DG C50_5.TG C54_1.TG C56_1.TG C46_4.TG C50_6.TG C62_4.TG C56_5.TG C56_2.TG C48_1.TG C58_5.TG C58_8.TG C46_0.TG C62_3.TG C56_0.TG C48_2.TG C56_6.TG C50_1.TG C54_6.TG C52_1.TG C58_4.TG C52_5.TG C54_7.TG C48_0.TG C56_8.TG C36_0.aDG C58_2.TG C32_0.DG C56_4.TG C50_2.TG C52_4.TG C54_4.TG C62_5.TG C40_2.TG C58_9.TG C48_4.TG C42_3.TG C52_6.TG C42_2.TG C44_0.TG C56_7.TG C44_1.TG C48_3.TG C52_7.TG C38_1.TG C44_2.TG C58_6.TG C42_0.DG C58_7.TG C46_1.TG C46_2.TG C34_0.DG C50_0.TG C62_1.TG C54_2.TG C60_2.TG C60_4.TG C32_0.aDG C52_3.TG C60_0.TG C60_3.TG C62_2.TG C52_0.TG C34_0.aDG C52_2.TG C32_2.aDG C18_2.MG C34_1.aDG C34_2.aDG C36_0.DG C24_0.FA C38_6.DG C16_0.MG C36_3.aDG C38_1.DG C18_0.MG C36_1.aDG C18_1.MG C36_1.DG C54_3.TG C32_1.aDG C34_3.aDG C30_1.aDG C36_4.aDG C22_2.FA C22_1.FA C40_3.DG C44_1.DG C20_2.FA C20_3.FA C22_3.FA C20_4.FA C34_4.aDG C42_2.DG C18_0.FaCN C20_1.FA C40_7.aDG C22_4.FA C44_2.DG C40_6.DG C30_2.aDG C22_6.FA C40_5.DG C18_0.FA C38_5.DG C22_5.FA C40_2.DG C18_1.FA C26_1.FA C30_1.DG C38_2.DG C32_3.aDG C36_2.DG C18_2.FA C24_1.FA C38_3.DG C38_4.DG C14_1.FA C16_0.FA C32_2.DG C32_1.DG C36_2.aDG C34_1.DG C40_7.DG C26_0.FA C38_6.aDG C38_4.aDG C38_5.aDG C38_3.aDG C36_3.DG C14_0.FA C16_0.FaCN C16_1.FA C34_2.DG C16_1.MG C34_3.DG C40_6.aDG C36_5.aDG C40_4.DG C38_2.aDG C40_5.aDG ID MDA-MB-468 Neutral Lipids Control 0.3μM 3μM MDA-MB-468 C38_1.TG C30_2.aDG C38_3.aDG C40_5.aDG C18_0.FaCN C32_1.aDG C36_5.aDG C18_0.FA C38_5.aDG C38_4.aDG C40_7.aDG C32_2.aDG C14_1.FA C38_6.aDG C16_0.FA C34_2.DG C34_3.DG C30_1.DG C38_4.DG C40_6.aDG C32_1.DG C32_0.aDG C32_2.DG C36_2.aDG C14_0.FA C16_1.FA C36_4.DG C38_0.TG C34_3.aDG C36_4.aDG C30_1.aDG C34_1.aDG C34_2.aDG C36_3.aDG C18_1.FA C36_1.aDG C16_0.FaCN C18_2.FA C38_2.aDG C40_2.TG C32_3.aDG C38_3.DG C24_1.FA C36_0.aDG C38_2.DG C40_3.DG C16_0.MG C36_1.DG C34_0.aDG C20_4.FA C18_0.MG C26_0.FA C32_0.DG C36_2.DG C18_2.MG C42_3.TG C34_1.DG C38_5.DG C16_1.MG C24_0.FA C36_3.DG C34_4.aDG C30_0.DG C56_8.TG C52_5.TG C54_7.TG C56_7.TG C58_7.TG C58_8.TG C48_3.TG C50_4.TG C52_7.TG C56_4.TG C52_4.TG C54_5.TG C56_5.TG C58_6.TG C50_5.TG C58_5.TG C20_2.FA C56_6.TG C58_4.TG C54_6.TG C50_3.TG C52_6.TG C50_6.TG C58_9.TG C20_1.FA C62_0.TG C22_5.FA C38_6.DG C40_1.DG C38_1.DG C40_2.DG C26_1.FA C36_0.DG C40_1.TG C40_0.DG C52_0.TG C40_5.DG C22_4.FA C42_0.DG C22_2.FA C42_1.DG C20_3.FA C58_0.TG C40_4.DG C44_4.TG C42_2.DG C42_0.TG C48_0.TG C60_0.TG C40_0.TG C56_0.TG C50_0.TG C44_1.DG C34_0.DG C42_1.TG C44_2.DG C60_2.TG C56_1.TG C60_1.TG C22_1.FA C46_0.TG C44_1.TG C58_1.TG C40_6.DG C46_3.TG C52_1.TG C62_1.TG C62_5.TG C62_3.TG C22_6.FA C44_3.TG C62_2.TG C54_1.TG C62_4.TG C50_1.TG C48_1.TG C58_2.TG C42_2.TG C44_0.TG C46_1.TG C60_4.TG C54_0.TG C52_3.TG C64_1.TG C54_2.TG C52_2.TG C56_2.TG C60_3.TG C58_3.TG C48_4.TG C56_3.TG C46_2.TG C50_2.TG C46_4.TG C18_1.MG C64_2.TG C40_7.DG C64_3.TG C44_2.TG C54_4.TG C22_3.FA C48_2.TG C54_3.TG ID C28_1.PA C30_2.aPC C36_0.aPC C72_4.CL C44_8.aPE C46_9.aPE C46_8.aPE C36_5.aPC C40_9.PI C38_7.aPC C40_8.aPC C28_1.PE C42_7.aPC C40_6.aPE C30_1.aPC C42_1.PE C36_6.aPC C36_1.aPE C40_8.PI C38_0.PI C42_7.PC C40_5.aPE C18_0.LPC C14_1.aLPC C16_1.aLPC C38_6.aPC C40_3.aPE C18_2.aLPC C36_1.PC C38_6.PC C70_3.CL C42_4.PC C26_0.PC C70_4.CL C40_8.PC C40_6.PE C74_8.CL C40_1.PE C40_5.aPC C40_3.PC C42_5.PS C40_7.PC C46_5.aPE C40_2.PC C40_7.aPC C44_5.PC C40_6.PC C38_6.aPE C40_4.PI C40_6.PI C26_0.aPC C40_5.PC C42_6.aPC C40_3.PE C40_5.PI C38_1.PG C42_6.PE C42_8.PE C42_5.PI C42_5.PC C40_4.PE C38_4.aPE C44_7.PC C40_1.aPC C16_2.aLPC C42_6.PC C72_7.CL C40_6.aPC C40_4.PC C40_3.PI C38_2.PC C36_4.aPE C38_3.aPE C40_4.aPE C40_6.PS C42_6.PI C42_7.aPE C46_7.aPE C44_7.aPE C46_6.aPE C42_6.aPE C44_6.aPE C36_0.PA C72_5.CL C22_1.aLPC C42_5.aPE C74_7.CL C42_8.aPE C44_5.aPE C74_5.CL C20_1.aLPC C40_9.PE C38_1.PC C42_6.PS C72_6.CL C38_5.aPE C40_7.aPE C42_4.aPE C40_8.aPE C28_0.LPC C38_7.aPE C36_5.aPE C40_9.aPE C12_0.LPC C40_5.PA C32_1.PA C34_1.PA C40_0.PS C20_4.LPC C40_6.PA C42_6.PA C32_2.PA C38_4.PA C34_3.aPC C36_4.aPC C40_3.aPC C36_6.PC C42_4.aPC C42_3.PE C34_0.PC C38_1.aPC C38_6.PE C38_2.aPC C40_2.aPC C20_1.LPC C70_5.CL C38_3.PC C36_6.aPE C42_7.PE C42_2.PE C44_6.PC C28_0.PE C66_3.CL C38_7.PC C40_5.PE C38_2.aPE C36_1.aPC C40_2.PE C42_9.PE C40_5.PS C42_1.PS C74_9.CL C36_1.PG C38_3.aPC C42_4.PI C24_0.LPC C38_3.PA C70_6.CL C20_2.LPC C38_2.PE C36_3.aPE C40_7.PI C42_5.aPC C42_4.PE C42_2.PS C18_1.aLPC C74_6.CL C38_1.PE C42_7.PI C28_0.PC C38_5.aPC C38_4.aPC C72_8.CL C42_5.PE C40_4.aPC C34_0.PI C20_0.LPC C34_1.PG C38_6.PI C38_3.PI C34_0.aPC C34_0.PA C38_3.PE C38_4.PI C38_4.PE C38_1.PI C34_1.PC C40_2.PI C26_1.LPC C30_0.PC C36_2.aPC C36_4.PI C36_3.aPC C18_3.aLPC C36_6.PE C38_4.PC C36_2.aPE C40_1.PS C36_1.PA C38_5.PC C40_7.PE C42_4.PS C38_2.PI C40_7.PG C36_1.PS C68_4.CL C40_8.PE C38_1.PS C36_4.PC C40_3.PA C38_5.PE C36_4.PE C28_1.aPE C28_0.aPC C70_7.CL C40_7.PS C36_1.PI C40_2.PS C66_4.CL C36_2.PS C62_3.CL C16_0.LPA C32_1.PC C36_3.PE C30_0.aPC C66_5.CL C38_2.PS C30_1.PE C34_1.aPE C38_7.PE C32_1.PI C22_0.aLPC C28_0.PA C30_0.PA C36_5.PE C34_4.aPE C38_3.PS C68_6.CL C34_1.PE C36_2.PI C34_0.PE C28_2.aPE C28_1.PC C36_0.PE C34_1.PS C36_3.PI C32_2.aPC C24_1.LPC C32_0.PG C68_5.CL C36_3.PC C68_3.CL C64_3.CL C16_0.LPC C30_0.PG C34_1.PI C34_0.PS C36_0.PI C36_5.PI C32_0.PI C38_2.PA C34_2.aPC 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C58_2.TG C44_0.TG C60_2.TG C62_3.TG C56_0.TG C30_0.DG C42_1.TG C20_2.FA C40_2.DG C44_1.DG C30_1.DG C34_0.aDG C64_3.TG C40_0.TG C44_3.TG C32_1.DG C20_1.FA C22_2.FA C24_1.FA C46_4.TG C20_3.FA C26_1.FA C26_0.FA C38_3.aDG C18_0.MG C22_3.FA C22_4.FA C18_2.FA C36_2.aDG C32_3.aDG C32_2.aDG C34_2.aDG C36_4.aDG C42_3.TG C24_0.FA C18_1.FA C22_6.FA C16_1.FA C32_1.aDG C22_5.FA C36_0.DG ID C36_1.aPC C36_2.PE C36_2.PG C40_6.PG C16_0.LPC C74_5.CL C20_2.LPC C38_1.aPC C34_2.PE C40_6.PC C32_0.aPC C18_2.aLPC C34_0.PE C38_7.PG C38_2.aPC C36_3.PE C40_7.PG C42_4.aPC C22_0.aLPC C36_5.PE C18_3.aLPC C34_0.PC C40_4.aPC C40_8.PC C14_0.LPC C38_4.aPC C18_1.aLPC C36_1.PE C36_6.PC C38_2.PS C40_2.PS C32_2.aPE C36_5.aPE C36_1.PS C40_6.PI C40_6.PA C36_2.PS C70_7.CL C34_2.aPC C34_2.aPE C38_6.aPC C38_5.PI C36_5.aPC C38_7.PE C36_3.PS C34_2.PA C30_2.PC C34_3.aPE C32_2.aPC C34_3.aPC C36_2.PA C32_2.PE C68_6.CL C74_6.CL C38_1.PS C34_2.PI C42_4.PS C34_3.PI C36_3.PA C34_2.PS C32_1.PA C34_3.PS C32_2.PA C36_4.PI C34_4.aPE 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C32_1.PE C36_1.aPE C32_0.PE C26_0.aPC C26_0.PC C30_0.aPE C40_3.PI C44_7.PC C42_6.aPC C44_5.PC C42_2.PE C36_1.PI C30_0.PC C42_5.PI C20_1.aLPC C70_3.CL C40_1.PS C38_2.aPE C42_6.PI C38_6.PS C28_0.PE C42_1.PS C38_1.PI C64_4.CL C28_0.PC C30_0.PE C36_3.aPE C40_2.PI C40_3.PE C38_2.PG C24_1.LPC C24_0.aLPC C42_5.PS C40_4.PE C32_0.PI C42_6.PS C44_6.PC C46_5.aPE C30_0.PI C40_4.PI C42_4.PI C26_1.LPC C40_3.PA C32_0.aPE C38_3.aPE ID C38_1.TG C44_4.TG C16_0.MG C44_2.DG C38_1.DG C42_0.TG C34_0.aDG C34_0.DG C40_0.TG C58_1.TG C18_1.MG C56_0.TG C56_1.TG C40_1.DG C60_2.TG C62_3.TG C54_0.TG C48_0.TG C50_0.TG C32_0.DG C40_2.TG C30_0.DG C58_2.TG C46_0.TG C26_0.FA C44_0.TG C42_0.DG C36_0.aDG C42_1.TG C46_4.TG C62_1.TG C58_0.TG C44_3.TG C44_1.DG C64_3.TG C42_2.DG C60_1.TG C40_0.DG C62_2.TG C42_2.TG C40_1.TG C42_1.DG C52_0.TG C18_2.MG C64_2.TG C22_1.FA C54_3.TG C20_2.FA C50_3.TG C48_3.TG C38_3.DG C56_4.TG C18_0.FA C24_0.FA C36_3.DG C58_5.TG C38_6.DG C54_4.TG C40_4.DG C52_6.TG C50_4.TG C50_5.TG C16_1.FA C38_5.DG C56_6.TG C16_1.MG C14_1.FA C38_2.aDG C36_1.aDG C32_1.aDG C38_0.TG C58_6.TG C24_1.FA C54_5.TG C40_5.DG C18_1.FA C22_2.FA C30_1.aDG C52_5.TG C56_5.TG C32_2.DG C52_4.TG C34_1.DG C20_1.FA C38_2.DG C58_3.TG C32_0.aDG C60_4.TG C46_2.TG C50_1.TG C56_2.TG C62_4.TG C44_1.TG C60_3.TG C30_1.DG C46_3.TG C44_2.TG C52_1.TG C62_5.TG C46_1.TG C54_1.TG C40_2.DG C48_1.TG C32_1.DG C36_1.DG C26_1.FA C52_7.TG C48_4.TG C48_2.TG C54_2.TG C52_2.TG C50_2.TG C56_3.TG C40_3.DG C14_0.FA C50_6.TG C52_3.TG C16_0.FA C34_2.DG C36_4.DG C58_4.TG C34_4.aDG C36_2.DG C18_0.MG C30_2.aDG C36_0.DG C36_3.aDG C20_3.FA C40_6.DG C38_3.aDG C38_4.DG C18_2.FA C34_3.aDG C22_4.FA C34_3.DG C54_6.TG C22_3.FA C34_1.aDG C36_4.aDG C36_2.aDG C34_2.aDG C38_4.aDG C40_7.aDG C40_6.aDG C58_7.TG C22_6.FA C18_0.FaCN C40_5.aDG C22_5.FA C54_7.TG C32_2.aDG C40_7.DG C56_7.TG C32_3.aDG C38_5.aDG C20_4.FA C38_6.aDG C16_0.FaCN C58_9.TG C56_8.TG C36_5.aDG C58_8.TG ID C40_2.PE C70_5.CL C38_3.PA C68_3.CL C30_1.aPE C36_3.aPE C38_6.PS C20_1.LPC C40_6.PS C74_9.CL C40_5.PI C40_3.PC C70_6.CL C38_2.PE C38_7.PE C36_4.aPE C32_0.PE C38_2.aPE C34_1.PE C74_7.CL C74_5.CL C30_1.PS C44_8.aPE C68_5.CL C34_0.PI C40_9.aPE C40_1.PS C42_7.PC C36_3.PE C46_7.aPE C40_2.PC C16_2.aLPC C42_5.PS C36_3.PI C36_1.PG C38_6.aPE C36_3.PA C70_7.CL C36_4.PI C42_5.PA C40_7.PC C40_5.PS C32_0.PS C38_2.PG C40_3.PG C32_2.PI C36_2.PA C40_4.PC C16_0.aLPC C42_5.aPC C32_2.PE C42_4.PS C40_6.aPC C34_1.PS C34_3.aPE C38_3.PI C34_0.PC C40_3.aPC C38_2.PC C30_1.aPC C26_1.aLPC C34_4.PE C28_0.PS C30_0.PS C40_5.aPC C40_7.PS C34_2.PE C36_2.PE C74_6.CL C32_1.PS C40_8.aPC C36_2.aPE C34_2.PI C38_1.PE C36_2.PI C40_5.PC C34_1.aPE C34_1.PG C34_4.aPE C70_4.CL C38_1.PI C40_3.aPE C30_0.PA C36_6.PE C72_4.CL C72_8.CL C44_5.PC C66_5.CL C42_1.PE C30_0.PG C32_1.PI C64_4.CL C28_1.PC C40_6.aPE C30_1.PE C28_0.PE C42_3.PE C42_5.PI C68_6.CL C40_1.aPC C66_3.CL C42_4.aPC C42_2.PE C42_6.aPE C44_6.PC C34_0.aPC C28_0.PC C64_3.CL C42_5.aPE C42_6.PS C40_4.aPE C40_5.aPE C38_6.PE C40_5.PE C38_3.aPE C46_5.aPE C46_9.aPE C72_7.CL C38_4.aPE C30_1.PI C32_1.PG C40_4.PA C42_7.aPC C36_4.PE C38_2.PI C34_1.PI C46_6.aPE C38_1.PC C44_5.aPE C36_0.PI C40_4.PE C34_1.PA C66_4.CL C40_7.aPE C18_3.aLPC C36_1.aPE C38_7.aPE C38_6.PI C40_3.PE C42_7.aPE C38_4.PE C30_0.PC C38_5.aPE C42_2.PS C42_7.PI C72_5.CL C30_0.PE C32_0.aPE C14_1.aLPC C36_5.PE C32_0.PG C40_1.PE C42_1.PS C40_8.aPE C40_6.PI C40_3.PI C44_7.PC C40_4.PI C40_7.PI C42_4.PC C46_8.aPE C42_6.PC C36_1.PI C42_6.aPC C38_0.PI C74_8.CL C30_0.aPE C38_5.PE C44_6.aPE C38_3.PE C42_8.aPE C26_0.aPC C72_6.CL C44_7.aPE C42_5.PC C68_4.CL C32_1.PE C38_1.PG C16_1.aLPC C22_0.aLPC C40_3.PA C40_2.aPC C24_0.aLPC C20_1.aLPC C40_8.PE C42_9.PE C66_2.CL C26_0.PC C40_7.PE C24_1.LPC C42_6.PE C42_4.PE C30_1.PG C26_1.LPC C42_5.PE C40_2.PI C40_6.PE C70_3.CL C42_7.PE C42_8.PE C32_0.PI C42_6.PI C32_1.PA C62_3.CL C24_0.LPC C34_0.PA C32_0.PA C30_0.PI C42_4.PI C20_0.LPC C42_4.aPE C18_1.LPA C32_2.PC C36_4.PG C40_6.PA C36_4.PC C38_4.PI C42_6.PA C38_5.PG C42_7.PA C38_5.PC C38_7.PC C36_4.aPC C34_3.PI C36_3.PG C40_7.PG C38_5.aPC C12_0.LPC C14_0.aLPC C34_3.PC C34_4.PC C36_5.aPC C38_6.aPC C40_5.PA C38_4.aPC C36_4.PS C40_6.PG C34_2.aPC C38_1.aPC C30_2.PC C36_2.aPC C34_3.PS C34_2.PG C34_2.PC C32_1.aPC C32_0.aPC C32_2.aPC C38_4.PC C38_4.PG C34_3.aPC C36_2.PG C38_6.PC C36_1.aPC C36_1.PA C36_3.aPC C36_3.PC C38_7.aPC C36_0.PE C34_2.PA C32_1.PC C32_2.PG C16_0.LPC C36_2.PC C14_0.LPC C40_5.PG C36_1.PS C34_0.PG C20_2.LPC C36_6.aPE C34_1.PC C38_5.PS C40_3.PS C40_4.aPC C38_4.PS C38_3.PG C30_2.aPC C38_5.PI C40_4.PS C38_2.PS C28_0.aPC C34_0.PE C34_2.PS C36_1.PC C40_4.PG C38_3.aPC C38_2.PA C38_3.PC C38_2.aPC C30_1.PC C38_1.PS C36_5.aPE C28_1.aPE C34_3.PE C36_3.PS C36_5.PI C30_2.aPE C36_0.PG C32_1.aPE C32_2.aPE C40_8.PC C18_0.LPC C32_0.PC C34_0.PS C38_3.PS C40_8.PI C34_2.aPE C36_1.PE C40_2.PS C36_2.PS C30_0.aPC C40_7.aPC C28_2.aPE C40_6.PC C16_0.LPA C20_0.aLPC C24_1.aLPC C20_3.LPC C20_4.LPC C18_2.aLPC C16_1.LPC C32_2.PA C38_7.PG C36_6.PC C18_2.LPC C36_5.PG C38_4.PA C18_1.aLPC C38_6.PG C36_5.PC C18_1.LPC C32_3.PC C34_3.PG ID 1 0.5 0 0.5 1 Neutral Lipids Control 0.3μM 3μM Phospholipids Control 0.3μM 3μM Neutral Lipids Control 0.1μM 0.3μM Phospholipids Control 0.1μM 0.3μM Phospholipids Control 0.1μM 1μM Neutral Lipids Control 0.1μM 1μM Fold Change G CN G G G G G G G G G G CN G G G G G G G G G G G G G G C36_1.aPC C36_2.PE C36_2.PG C40_6.PG C16_0.LPC C74_5.CL C20_2.LPC C38_1.aPC C34_2.PE C40_6.PC C32_0.aPC C18_2.aLPC C34_0.PE C38_7.PG C38_2.aPC C36_3.PE C40_7.PG C42_4.aPC C22_0.aLPC C36_5.PE C18_3.aLPC C34_0.PC C40_4.aPC C40_8.PC C14_0.LPC C38_4.aPC C18_1.aLPC C36_1.PE C36_6.PC C38_2.PS C40_2.PS C32_2.aPE C36_5.aPE C36_1.PS C40_6.PI C40_6.PA C36_2.PS C70_7.CL C34_2.aPC C34_2.aPE C38_6.aPC C38_5.PI C36_5.aPC C38_7.PE C36_3.PS C34_2.PA C30_2.PC C34_3.aPE C32_2.aPC C34_3.aPC C36_2.PA C32_2.PE C68_6.CL C74_6.CL C38_1.PS C34_2.PI C42_4.PS C34_3.PI C36_3.PA C34_2.PS C32_1.PA C34_3.PS C32_2.PA C36_4.PI C34_4.aPE C38_4.PA C36_5.PI C40_3.PS C36_6.aPE C18_1.LPA C38_4.PI C32_2.PC C34_3.PC C34_3.PG C32_3.PC C34_3.PE C36_4.PS C34_4.PC C36_1.PA C36_0.PE C74_9.CL C34_1.PA C36_3.PC C36_3.PG C38_7.PC C32_1.aPC C36_5.PG C34_2.PC C36_5.PC C14_0.aLPC C38_4.PS C36_4.PC C38_5.PC C32_1.PC C36_4.PG C38_5.PG C34_1.PC C38_4.PC C38_6.PC C36_2.PC C38_5.aPC C34_2.PG C20_3.LPC C12_0.LPC C18_1.LPC C16_1.LPC C34_0.PG C20_4.LPC C38_6.PG C18_2.LPC C38_4.PG C32_0.PC C40_5.PI C36_0.PI C36_2.aPC C42_5.PA C34_1.PG C38_5.PS C72_4.CL C36_4.aPC C72_8.CL C38_3.PC C18_0.LPC C16_0.LPA C32_1.aPE C36_1.PC C36_3.aPC C32_2.PG C28_1.aPE C38_6.aPE C34_1.PS C40_8.PE C36_3.PI C70_6.CL C40_8.aPC C40_7.PE C40_8.aPE C68_5.CL C32_2.PI C42_9.PE C72_7.CL C40_4.PS C36_2.PI C40_8.PI C38_7.aPC C38_3.PI C38_3.PS C30_2.aPC C38_2.PA C40_9.aPE C40_7.PI C40_5.PA C38_3.PA C40_7.PS C40_4.PA C38_6.PI C42_8.PE C30_1.aPE C74_8.CL C38_7.aPE C38_5.aPE C32_1.PS C70_5.CL C68_4.CL C70_4.CL C30_1.aPC C66_4.CL C66_5.CL C40_7.aPE C32_1.PI C30_1.PC C44_6.aPE C44_7.aPE C40_5.PS C68_3.CL C42_5.PE C34_4.PE C38_0.PI C42_6.aPE C40_6.aPE C42_5.aPE C42_7.aPE C42_8.aPE C30_1.PI C44_5.aPE C66_3.CL C14_1.aLPC C42_2.PS C46_6.aPE C72_6.CL C44_8.aPE C46_7.aPE C42_7.PE C46_9.aPE C28_0.aPC C38_3.aPC C30_0.aPC C40_5.PC C36_0.PG C40_2.aPC C40_4.PC C16_0.aLPC C38_6.PE C40_7.PC C34_0.aPC C20_0.aLPC C16_1.aLPC C40_5.PG C38_4.PE C38_3.PG C34_1.PE C36_2.aPE C42_5.aPC C32_0.PG C40_3.PC C38_2.PE C38_1.PE C40_4.PG C40_5.aPC C20_1.LPC C38_2.PC C40_6.aPC C32_0.PS C38_3.PE C28_0.PA C40_1.PE C34_0.PA C40_3.PG C38_1.PC C32_0.PA C40_7.aPC C42_5.PC C28_0.PS C30_0.PS C36_4.PE C66_2.CL C40_2.PE C42_1.PE C42_6.PC C38_5.PE C36_1.PG C74_7.CL C40_3.aPC C34_1.aPE C42_7.PC C16_2.aLPC C30_0.PA C36_6.PE C40_3.aPE C40_5.PE C40_6.PE C30_1.PE C30_0.PG C34_0.PI C28_1.PC C34_0.PS C40_6.PS C38_4.aPE C64_3.CL C32_1.PG C42_7.aPC C42_7.PI C40_4.aPE C24_1.aLPC C34_1.PI C38_2.PI C20_0.LPC C42_6.PE C72_5.CL C42_4.PE C38_1.PG C62_3.CL C40_5.aPE C42_4.aPE C42_3.PE C40_2.PC C42_4.PC C36_4.aPE C32_1.PE C36_1.aPE C32_0.PE C26_0.aPC C26_0.PC C30_0.aPE C40_3.PI C44_7.PC C42_6.aPC C44_5.PC C42_2.PE C36_1.PI C30_0.PC C42_5.PI C20_1.aLPC C70_3.CL C40_1.PS C38_2.aPE C42_6.PI C38_6.PS C28_0.PE C42_1.PS C38_1.PI C64_4.CL C28_0.PC C30_0.PE C36_3.aPE C40_2.PI C40_3.PE C38_2.PG C24_1.LPC C24_0.aLPC C42_5.PS C40_4.PE C32_0.PI C42_6.PS C44_6.PC C46_5.aPE C30_0.PI C40_4.PI C42_4.PI C26_1.LPC C40_3.PA C32_0.aPE C38_3.aPE ID C38_1.TG C44_4.TG C16_0.MG C44_2.DG C38_1.DG C42_0.TG C34_0.aDG C34_0.DG C40_0.TG C58_1.TG C18_1.MG C56_0.TG C56_1.TG C40_1.DG C60_2.TG C62_3.TG C54_0.TG C48_0.TG C50_0.TG C32_0.DG C40_2.TG C30_0.DG C58_2.TG C46_0.TG C26_0.FA C44_0.TG C42_0.DG C36_0.aDG C42_1.TG C46_4.TG C62_1.TG C58_0.TG C44_3.TG C44_1.DG C64_3.TG C42_2.DG C60_1.TG C40_0.DG C62_2.TG C42_2.TG C40_1.TG C42_1.DG C52_0.TG C18_2.MG C64_2.TG C22_1.FA C54_3.TG C20_2.FA C50_3.TG C48_3.TG C38_3.DG C56_4.TG C18_0.FA C24_0.FA C36_3.DG C58_5.TG C38_6.DG C54_4.TG C40_4.DG C52_6.TG C50_4.TG C50_5.TG C16_1.FA C38_5.DG C56_6.TG C16_1.MG C14_1.FA C38_2.aDG C36_1.aDG C32_1.aDG C38_0.TG C58_6.TG C24_1.FA C54_5.TG C40_5.DG C18_1.FA C22_2.FA C30_1.aDG C52_5.TG C56_5.TG C32_2.DG C52_4.TG C34_1.DG C20_1.FA C38_2.DG C58_3.TG C32_0.aDG C60_4.TG C46_2.TG C50_1.TG C56_2.TG C62_4.TG C44_1.TG C60_3.TG C30_1.DG C46_3.TG C44_2.TG C52_1.TG C62_5.TG C46_1.TG C54_1.TG C40_2.DG C48_1.TG C32_1.DG C36_1.DG C26_1.FA C52_7.TG C48_4.TG C48_2.TG C54_2.TG C52_2.TG C50_2.TG C56_3.TG C40_3.DG C14_0.FA C50_6.TG C52_3.TG C16_0.FA C34_2.DG C36_4.DG C58_4.TG C34_4.aDG C36_2.DG C18_0.MG C30_2.aDG C36_0.DG C36_3.aDG C20_3.FA C40_6.DG C38_3.aDG C38_4.DG C18_2.FA C34_3.aDG C22_4.FA C34_3.DG C54_6.TG C22_3.FA C34_1.aDG C36_4.aDG C36_2.aDG C34_2.aDG C38_4.aDG C40_7.aDG C40_6.aDG C58_7.TG C22_6.FA C18_0.FaCN C40_5.aDG C22_5.FA C54_7.TG C32_2.aDG C40_7.DG C56_7.TG C32_3.aDG C38_5.aDG C20_4.FA C38_6.aDG C16_0.FaCN C58_9.TG C56_8.TG C36_5.aDG C58_8.TG ID C40_2.PE C70_5.CL C38_3.PA C68_3.CL C30_1.aPE C36_3.aPE C38_6.PS C20_1.LPC C40_6.PS C74_9.CL C40_5.PI C40_3.PC C70_6.CL C38_2.PE C38_7.PE C36_4.aPE C32_0.PE C38_2.aPE C34_1.PE C74_7.CL C74_5.CL C30_1.PS C44_8.aPE C68_5.CL C34_0.PI C40_9.aPE C40_1.PS C42_7.PC C36_3.PE C46_7.aPE C40_2.PC C16_2.aLPC C42_5.PS C36_3.PI C36_1.PG C38_6.aPE C36_3.PA C70_7.CL C36_4.PI C42_5.PA C40_7.PC C40_5.PS C32_0.PS C38_2.PG C40_3.PG C32_2.PI C36_2.PA C40_4.PC C16_0.aLPC C42_5.aPC C32_2.PE C42_4.PS C40_6.aPC C34_1.PS C34_3.aPE C38_3.PI C34_0.PC C40_3.aPC C38_2.PC C30_1.aPC C26_1.aLPC C34_4.PE C28_0.PS C30_0.PS C40_5.aPC C40_7.PS C34_2.PE C36_2.PE C74_6.CL C32_1.PS C40_8.aPC C36_2.aPE C34_2.PI C38_1.PE C36_2.PI C40_5.PC C34_1.aPE C34_1.PG C34_4.aPE C70_4.CL C38_1.PI C40_3.aPE C30_0.PA C36_6.PE C72_4.CL C72_8.CL C44_5.PC C66_5.CL C42_1.PE C30_0.PG C32_1.PI C64_4.CL C28_1.PC C40_6.aPE C30_1.PE C28_0.PE C42_3.PE C42_5.PI C68_6.CL C40_1.aPC C66_3.CL C42_4.aPC C42_2.PE C42_6.aPE C44_6.PC C34_0.aPC C28_0.PC C64_3.CL C42_5.aPE C42_6.PS C40_4.aPE C40_5.aPE C38_6.PE C40_5.PE C38_3.aPE C46_5.aPE C46_9.aPE C72_7.CL C38_4.aPE C30_1.PI C32_1.PG C40_4.PA C42_7.aPC C36_4.PE C38_2.PI C34_1.PI C46_6.aPE C38_1.PC C44_5.aPE C36_0.PI C40_4.PE C34_1.PA C66_4.CL C40_7.aPE C18_3.aLPC C36_1.aPE C38_7.aPE C38_6.PI C40_3.PE C42_7.aPE C38_4.PE C30_0.PC C38_5.aPE C42_2.PS C42_7.PI C72_5.CL C30_0.PE C32_0.aPE C14_1.aLPC C36_5.PE C32_0.PG C40_1.PE C42_1.PS C40_8.aPE C40_6.PI C40_3.PI C44_7.PC C40_4.PI C40_7.PI C42_4.PC C46_8.aPE C42_6.PC C36_1.PI C42_6.aPC C38_0.PI C74_8.CL C30_0.aPE C38_5.PE C44_6.aPE C38_3.PE C42_8.aPE C26_0.aPC C72_6.CL C44_7.aPE C42_5.PC C68_4.CL C32_1.PE C38_1.PG C16_1.aLPC C22_0.aLPC C40_3.PA C40_2.aPC C24_0.aLPC C20_1.aLPC C40_8.PE C42_9.PE C66_2.CL C26_0.PC C40_7.PE C24_1.LPC C42_6.PE C42_4.PE C30_1.PG C26_1.LPC C42_5.PE C40_2.PI C40_6.PE C70_3.CL C42_7.PE C42_8.PE C32_0.PI C42_6.PI C32_1.PA C62_3.CL C24_0.LPC C34_0.PA C32_0.PA C30_0.PI C42_4.PI C20_0.LPC C42_4.aPE C18_1.LPA C32_2.PC C36_4.PG C40_6.PA C36_4.PC C38_4.PI C42_6.PA C38_5.PG C42_7.PA C38_5.PC C38_7.PC C36_4.aPC C34_3.PI C36_3.PG C40_7.PG C38_5.aPC C12_0.LPC C14_0.aLPC C34_3.PC C34_4.PC C36_5.aPC C38_6.aPC C40_5.PA C38_4.aPC C36_4.PS C40_6.PG C34_2.aPC C38_1.aPC C30_2.PC C36_2.aPC C34_3.PS C34_2.PG C34_2.PC C32_1.aPC C32_0.aPC C32_2.aPC C38_4.PC C38_4.PG C34_3.aPC C36_2.PG C38_6.PC C36_1.aPC C36_1.PA C36_3.aPC C36_3.PC C38_7.aPC C36_0.PE C34_2.PA C32_1.PC C32_2.PG C16_0.LPC C36_2.PC C14_0.LPC C40_5.PG C36_1.PS C34_0.PG C20_2.LPC C36_6.aPE C34_1.PC C38_5.PS C40_3.PS C40_4.aPC C38_4.PS C38_3.PG C30_2.aPC C38_5.PI C40_4.PS C38_2.PS C28_0.aPC C34_0.PE C34_2.PS C36_1.PC C40_4.PG C38_3.aPC C38_2.PA C38_3.PC C38_2.aPC C30_1.PC C38_1.PS C36_5.aPE C28_1.aPE C34_3.PE C36_3.PS C36_5.PI C30_2.aPE C36_0.PG C32_1.aPE C32_2.aPE C40_8.PC C18_0.LPC C32_0.PC C34_0.PS C38_3.PS C40_8.PI C34_2.aPE C36_1.PE C40_2.PS C36_2.PS C30_0.aPC C40_7.aPC C28_2.aPE C40_6.PC C16_0.LPA C20_0.aLPC C24_1.aLPC C20_3.LPC C20_4.LPC C18_2.aLPC C16_1.LPC C32_2.PA C38_7.PG C36_6.PC C18_2.LPC C36_5.PG C38_4.PA C18_1.aLPC C38_6.PG C36_5.PC C18_1.LPC C32_3.PC C34_3.PG ID 1 0.5 0 0.5 1 Phospholipids Control 0.1μM 0.3μM Phospholipids Control 0.1μM 1μM Neutral Lipids Control 0.1μM 1μM Fold Change C38_1.TG C30_2.aDG C38_3.aDG C40_5.aDG C18_0.FaCN C32_1.aDG C36_5.aDG C18_0.FA C38_5.aDG C38_4.aDG C40_7.aDG C32_2.aDG C14_1.FA C38_6.aDG C16_0.FA C34_2.DG C34_3.DG C30_1.DG C38_4.DG C40_6.aDG C32_1.DG C32_0.aDG C32_2.DG C36_2.aDG C14_0.FA C16_1.FA C36_4.DG C38_0.TG C34_3.aDG C36_4.aDG C30_1.aDG C34_1.aDG C34_2.aDG C36_3.aDG C18_1.FA C36_1.aDG C16_0.FaCN C18_2.FA C38_2.aDG C40_2.TG C32_3.aDG C38_3.DG C24_1.FA C36_0.aDG C38_2.DG C40_3.DG C16_0.MG C36_1.DG C34_0.aDG C20_4.FA C18_0.MG C26_0.FA C32_0.DG C36_2.DG C18_2.MG C42_3.TG C34_1.DG C38_5.DG C16_1.MG C24_0.FA C36_3.DG C34_4.aDG C30_0.DG C56_8.TG C52_5.TG C54_7.TG C56_7.TG C58_7.TG C58_8.TG C48_3.TG C50_4.TG C52_7.TG C56_4.TG C52_4.TG C54_5.TG C56_5.TG C58_6.TG C50_5.TG C58_5.TG C20_2.FA C56_6.TG C58_4.TG C54_6.TG C50_3.TG C52_6.TG C50_6.TG C58_9.TG C20_1.FA C62_0.TG C22_5.FA C38_6.DG C40_1.DG C38_1.DG C40_2.DG C26_1.FA C36_0.DG C40_1.TG C40_0.DG C52_0.TG C40_5.DG C22_4.FA C42_0.DG C22_2.FA C42_1.DG C20_3.FA C58_0.TG C40_4.DG C44_4.TG C42_2.DG C42_0.TG C48_0.TG C60_0.TG C40_0.TG C56_0.TG C50_0.TG C44_1.DG C34_0.DG C42_1.TG C44_2.DG C60_2.TG C56_1.TG C60_1.TG C22_1.FA C46_0.TG C44_1.TG C58_1.TG C40_6.DG C46_3.TG C52_1.TG C62_1.TG C62_5.TG C62_3.TG C22_6.FA C44_3.TG C62_2.TG C54_1.TG C62_4.TG C50_1.TG C48_1.TG C58_2.TG C42_2.TG C44_0.TG C46_1.TG C60_4.TG C54_0.TG C52_3.TG C64_1.TG C54_2.TG C52_2.TG C56_2.TG C60_3.TG C58_3.TG C48_4.TG C56_3.TG C46_2.TG C50_2.TG C46_4.TG C18_1.MG C64_2.TG C40_7.DG C64_3.TG C44_2.TG C54_4.TG C22_3.FA C48_2.TG C54_3.TG ID C28_1.PA C30_2.aPC C36_0.aPC C72_4.CL C44_8.aPE C46_9.aPE C46_8.aPE C36_5.aPC C40_9.PI C38_7.aPC C40_8.aPC C28_1.PE C42_7.aPC C40_6.aPE C30_1.aPC C42_1.PE C36_6.aPC C36_1.aPE C40_8.PI C38_0.PI C42_7.PC C40_5.aPE C18_0.LPC C14_1.aLPC C16_1.aLPC C38_6.aPC C40_3.aPE C18_2.aLPC C36_1.PC C38_6.PC C70_3.CL C42_4.PC C26_0.PC C70_4.CL C40_8.PC C40_6.PE C74_8.CL C40_1.PE C40_5.aPC C40_3.PC C42_5.PS C40_7.PC C46_5.aPE C40_2.PC C40_7.aPC C44_5.PC C40_6.PC C38_6.aPE C40_4.PI C40_6.PI C26_0.aPC C40_5.PC C42_6.aPC C40_3.PE C40_5.PI C38_1.PG C42_6.PE C42_8.PE C42_5.PI C42_5.PC C40_4.PE C38_4.aPE C44_7.PC C40_1.aPC C16_2.aLPC C42_6.PC C72_7.CL C40_6.aPC C40_4.PC C40_3.PI C38_2.PC C36_4.aPE C38_3.aPE C40_4.aPE C40_6.PS C42_6.PI C42_7.aPE C46_7.aPE C44_7.aPE C46_6.aPE C42_6.aPE C44_6.aPE C36_0.PA C72_5.CL C22_1.aLPC C42_5.aPE C74_7.CL C42_8.aPE C44_5.aPE C74_5.CL C20_1.aLPC C40_9.PE C38_1.PC C42_6.PS C72_6.CL C38_5.aPE C40_7.aPE C42_4.aPE C40_8.aPE C28_0.LPC C38_7.aPE C36_5.aPE C40_9.aPE C12_0.LPC C40_5.PA C32_1.PA C34_1.PA C40_0.PS C20_4.LPC C40_6.PA C42_6.PA C32_2.PA C38_4.PA C34_3.aPC C36_4.aPC C40_3.aPC C36_6.PC C42_4.aPC C42_3.PE C34_0.PC C38_1.aPC C38_6.PE C38_2.aPC C40_2.aPC C20_1.LPC C70_5.CL C38_3.PC C36_6.aPE C42_7.PE C42_2.PE C44_6.PC C28_0.PE C66_3.CL C38_7.PC C40_5.PE C38_2.aPE C36_1.aPC C40_2.PE C42_9.PE C40_5.PS C42_1.PS C74_9.CL C36_1.PG C38_3.aPC C42_4.PI C24_0.LPC C38_3.PA C70_6.CL C20_2.LPC C38_2.PE C36_3.aPE C40_7.PI C42_5.aPC C42_4.PE C42_2.PS C18_1.aLPC C74_6.CL C38_1.PE C42_7.PI C28_0.PC C38_5.aPC C38_4.aPC C72_8.CL C42_5.PE C40_4.aPC C34_0.PI C20_0.LPC C34_1.PG C38_6.PI C38_3.PI C34_0.aPC C34_0.PA C38_3.PE C38_4.PI C38_4.PE C38_1.PI C34_1.PC C40_2.PI C26_1.LPC C30_0.PC C36_2.aPC C36_4.PI C36_3.aPC C18_3.aLPC C36_6.PE C38_4.PC C36_2.aPE C40_1.PS C36_1.PA C38_5.PC C40_7.PE C42_4.PS C38_2.PI C40_7.PG C36_1.PS C68_4.CL C40_8.PE C38_1.PS C36_4.PC C40_3.PA C38_5.PE C36_4.PE C28_1.aPE C28_0.aPC C70_7.CL C40_7.PS C36_1.PI C40_2.PS C66_4.CL C36_2.PS C62_3.CL C16_0.LPA C32_1.PC C36_3.PE C30_0.aPC C66_5.CL C38_2.PS C30_1.PE C34_1.aPE C38_7.PE C32_1.PI C22_0.aLPC C28_0.PA C30_0.PA C36_5.PE C34_4.aPE C38_3.PS C68_6.CL C34_1.PE C36_2.PI C34_0.PE C28_2.aPE C28_1.PC C36_0.PE C34_1.PS C36_3.PI C32_2.aPC C24_1.LPC C32_0.PG C68_5.CL C36_3.PC C68_3.CL C64_3.CL C16_0.LPC C30_0.PG C34_1.PI C34_0.PS C36_0.PI C36_5.PI C32_0.PI C38_2.PA C34_2.aPC C38_5.PI C36_2.PC C36_1.PE C36_5.PC C32_0.PA C32_0.PE C66_2.CL C32_0.PC C30_0.PE C38_3.PG C38_5.PG C40_4.PG C38_4.PG C40_5.PG C30_1.PA C42_7.PA C16_1.LPC C36_0.PG C36_2.PG C32_3.PC C40_3.PG C34_2.PA C26_1.aLPC C38_2.PG C34_1.aPC C30_1.PC C18_1.LPC C36_2.PE C32_0.PS C40_4.PS C34_2.PC C40_3.PS C32_1.aPC C64_4.CL C16_0.aLPC C32_1.PG C36_3.PS C18_0.LPA C32_1.PE C38_5.PS C34_2.PI C34_3.aPE C30_0.PI C30_1.PI C32_2.PE C32_0.aPE C14_0.aLPC C34_3.PE C42_5.PA C30_0.aPE C20_0.aLPC C34_3.PS C30_1.PG C38_4.PS C40_6.PG C34_2.PS C32_2.PI C32_1.PS C34_3.PI C18_1.LPA C34_4.PE C34_2.PE C34_2.aPE C34_2.PG C36_5.PG C34_3.PC C40_4.PA C32_0.aPC C36_2.PA C32_2.PG C22_2.aLPC C18_2.LPC C32_1.aPE C34_4.PC C24_0.aLPC C38_6.PS C30_2.aPE C32_2.PC C32_2.aPE C38_7.PG C20_3.LPC C28_0.PS C30_0.PS C36_4.PG C24_1.aLPC C30_1.PS C14_0.LPC C34_0.PG C34_3.PG C30_2.PC C36_4.PS C36_3.PA C30_1.aPE C36_3.PG C38_6.PG ID C40_7.DG C54_6.TG C54_7.TG C34_3.DG C38_0.TG C16_0.FA C56_7.TG C36_0.aDG C56_8.TG C58_8.TG C38_4.DG C38_5.DG C16_0.FaCN C20_4.FA C34_2.DG C58_9.TG C18_0.FA C40_5.aDG C14_1.FA C34_4.aDG C40_7.aDG C36_5.aDG C38_5.aDG C34_3.aDG C36_3.aDG C40_6.aDG C38_4.aDG C38_6.aDG C16_1.MG C54_4.TG C50_4.TG C52_6.TG C32_2.DG C36_3.DG C38_1.TG C40_6.DG C54_5.TG C18_0.FaCN C38_6.DG C58_7.TG C52_7.TG C52_5.TG C56_6.TG C52_4.TG C14_0.FA C30_2.aDG C38_2.aDG C22_1.FA C40_5.DG C18_2.MG C16_0.MG C38_3.DG C50_3.TG C30_1.aDG C36_2.DG C50_5.TG C48_4.TG C52_3.TG C48_3.TG C56_5.TG C36_1.aDG C52_2.TG C56_4.TG C42_2.DG C48_2.TG C50_2.TG C40_3.DG C54_3.TG C58_6.TG C36_1.DG C18_1.MG C40_4.DG C46_3.TG C50_6.TG C34_1.aDG C48_1.TG C54_2.TG C44_2.DG C46_2.TG C42_0.DG C32_0.DG C50_1.TG C34_1.DG C40_1.DG C58_5.TG C38_2.DG C56_3.TG C58_4.TG C40_0.DG C60_0.TG C46_1.TG C42_2.TG C52_1.TG C42_0.TG C54_0.TG C32_0.aDG C48_0.TG C60_4.TG C64_2.TG C40_1.TG C62_4.TG C50_0.TG C56_2.TG C58_3.TG C60_3.TG C44_2.TG C46_0.TG C60_1.TG C34_0.DG C38_1.DG C42_1.DG C58_1.TG C56_1.TG C62_5.TG C52_0.TG C62_1.TG C58_0.TG C62_2.TG C44_1.TG C54_1.TG C40_2.TG C58_2.TG C44_0.TG C60_2.TG C62_3.TG C56_0.TG C30_0.DG C42_1.TG C20_2.FA C40_2.DG C44_1.DG C30_1.DG C34_0.aDG C64_3.TG C40_0.TG C44_3.TG C32_1.DG C20_1.FA C22_2.FA C24_1.FA C46_4.TG C20_3.FA C26_1.FA C26_0.FA C38_3.aDG C18_0.MG C22_3.FA C22_4.FA C18_2.FA C36_2.aDG C32_3.aDG C32_2.aDG C34_2.aDG C36_4.aDG C42_3.TG C24_0.FA C18_1.FA C22_6.FA C16_1.FA C32_1.aDG C22_5.FA C36_0.DG ID C36_1.aPC C36_2.PE C36_2.PG C40_6.PG C16_0.LPC C74_5.CL C20_2.LPC C38_1.aPC C34_2.PE C40_6.PC C32_0.aPC C18_2.aLPC C34_0.PE C38_7.PG C38_2.aPC C36_3.PE C40_7.PG C42_4.aPC C22_0.aLPC C36_5.PE C18_3.aLPC C34_0.PC C40_4.aPC C40_8.PC C14_0.LPC C38_4.aPC C18_1.aLPC C36_1.PE C36_6.PC C38_2.PS C40_2.PS C32_2.aPE C36_5.aPE C36_1.PS C40_6.PI C40_6.PA C36_2.PS C70_7.CL C34_2.aPC C34_2.aPE C38_6.aPC C38_5.PI C36_5.aPC C38_7.PE C36_3.PS C34_2.PA C30_2.PC C34_3.aPE C32_2.aPC C34_3.aPC C36_2.PA C32_2.PE C68_6.CL C74_6.CL C38_1.PS C34_2.PI C42_4.PS C34_3.PI C36_3.PA C34_2.PS C32_1.PA C34_3.PS C32_2.PA C36_4.PI C34_4.aPE C38_4.PA C36_5.PI C40_3.PS C36_6.aPE C18_1.LPA C38_4.PI C32_2.PC C34_3.PC C34_3.PG C32_3.PC C34_3.PE C36_4.PS C34_4.PC C36_1.PA C36_0.PE C74_9.CL C34_1.PA C36_3.PC C36_3.PG C38_7.PC C32_1.aPC C36_5.PG C34_2.PC C36_5.PC C14_0.aLPC C38_4.PS C36_4.PC C38_5.PC C32_1.PC C36_4.PG C38_5.PG C34_1.PC C38_4.PC C38_6.PC C36_2.PC C38_5.aPC C34_2.PG C20_3.LPC C12_0.LPC C18_1.LPC C16_1.LPC C34_0.PG C20_4.LPC C38_6.PG C18_2.LPC C38_4.PG C32_0.PC C40_5.PI C36_0.PI C36_2.aPC C42_5.PA C34_1.PG C38_5.PS C72_4.CL C36_4.aPC C72_8.CL C38_3.PC C18_0.LPC C16_0.LPA C32_1.aPE C36_1.PC C36_3.aPC C32_2.PG C28_1.aPE C38_6.aPE C34_1.PS C40_8.PE C36_3.PI C70_6.CL C40_8.aPC C40_7.PE C40_8.aPE C68_5.CL C32_2.PI C42_9.PE C72_7.CL C40_4.PS C36_2.PI C40_8.PI C38_7.aPC C38_3.PI C38_3.PS C30_2.aPC C38_2.PA C40_9.aPE C40_7.PI C40_5.PA C38_3.PA C40_7.PS C40_4.PA C38_6.PI C42_8.PE C30_1.aPE C74_8.CL C38_7.aPE C38_5.aPE C32_1.PS C70_5.CL C68_4.CL C70_4.CL C30_1.aPC C66_4.CL C66_5.CL C40_7.aPE C32_1.PI C30_1.PC C44_6.aPE C44_7.aPE C40_5.PS C68_3.CL C42_5.PE C34_4.PE C38_0.PI C42_6.aPE C40_6.aPE C42_5.aPE C42_7.aPE C42_8.aPE C30_1.PI C44_5.aPE C66_3.CL C14_1.aLPC C42_2.PS C46_6.aPE C72_6.CL C44_8.aPE C46_7.aPE C42_7.PE C46_9.aPE C28_0.aPC C38_3.aPC C30_0.aPC C40_5.PC C36_0.PG C40_2.aPC C40_4.PC C16_0.aLPC C38_6.PE C40_7.PC C34_0.aPC C20_0.aLPC C16_1.aLPC C40_5.PG C38_4.PE C38_3.PG C34_1.PE C36_2.aPE C42_5.aPC C32_0.PG C40_3.PC C38_2.PE C38_1.PE C40_4.PG C40_5.aPC C20_1.LPC C38_2.PC C40_6.aPC C32_0.PS C38_3.PE C28_0.PA C40_1.PE C34_0.PA C40_3.PG C38_1.PC C32_0.PA C40_7.aPC C42_5.PC C28_0.PS C30_0.PS C36_4.PE C66_2.CL C40_2.PE C42_1.PE C42_6.PC C38_5.PE C36_1.PG C74_7.CL C40_3.aPC C34_1.aPE C42_7.PC C16_2.aLPC C30_0.PA C36_6.PE C40_3.aPE C40_5.PE C40_6.PE C30_1.PE C30_0.PG C34_0.PI C28_1.PC C34_0.PS C40_6.PS C38_4.aPE C64_3.CL C32_1.PG C42_7.aPC C42_7.PI C40_4.aPE C24_1.aLPC C34_1.PI C38_2.PI C20_0.LPC C42_6.PE C72_5.CL C42_4.PE C38_1.PG C62_3.CL C40_5.aPE C42_4.aPE C42_3.PE C40_2.PC C42_4.PC C36_4.aPE C32_1.PE C36_1.aPE C32_0.PE C26_0.aPC C26_0.PC C30_0.aPE C40_3.PI C44_7.PC C42_6.aPC C44_5.PC C42_2.PE C36_1.PI C30_0.PC C42_5.PI C20_1.aLPC C70_3.CL C40_1.PS C38_2.aPE C42_6.PI C38_6.PS C28_0.PE C42_1.PS C38_1.PI C64_4.CL C28_0.PC C30_0.PE C36_3.aPE C40_2.PI C40_3.PE C38_2.PG C24_1.LPC C24_0.aLPC C42_5.PS C40_4.PE C32_0.PI C42_6.PS C44_6.PC C46_5.aPE C30_0.PI C40_4.PI C42_4.PI C26_1.LPC C40_3.PA C32_0.aPE C38_3.aPE ID Neutral Lipids Control 0.3μM 3μM Phospholipids Control 0.3μM 3μM Neutral Lipids Control 0.1μM 0.3μM Phospholipids Control 0.1μM 0.3μM C38_1.TG C30_2.aDG C38_3.aDG C40_5.aDG C18_0.FaCN C32_1.aDG C36_5.aDG C18_0.FA C38_5.aDG C38_4.aDG C40_7.aDG C32_2.aDG C14_1.FA C38_6.aDG C16_0.FA C34_2.DG C34_3.DG C30_1.DG C38_4.DG C40_6.aDG C32_1.DG C32_0.aDG C32_2.DG C36_2.aDG C14_0.FA C16_1.FA C36_4.DG C38_0.TG C34_3.aDG C36_4.aDG C30_1.aDG C34_1.aDG C34_2.aDG C36_3.aDG C18_1.FA C36_1.aDG C16_0.FaCN C18_2.FA C38_2.aDG C40_2.TG C32_3.aDG C38_3.DG C24_1.FA C36_0.aDG C38_2.DG C40_3.DG C16_0.MG C36_1.DG C34_0.aDG C20_4.FA C18_0.MG C26_0.FA C32_0.DG C36_2.DG C18_2.MG C42_3.TG C34_1.DG C38_5.DG C16_1.MG C24_0.FA C36_3.DG C34_4.aDG C30_0.DG C56_8.TG C52_5.TG C54_7.TG C56_7.TG C58_7.TG C58_8.TG C48_3.TG C50_4.TG C52_7.TG C56_4.TG C52_4.TG C54_5.TG C56_5.TG C58_6.TG C50_5.TG C58_5.TG C20_2.FA C56_6.TG C58_4.TG C54_6.TG C50_3.TG C52_6.TG C50_6.TG C58_9.TG C20_1.FA C62_0.TG C22_5.FA C38_6.DG C40_1.DG C38_1.DG C40_2.DG C26_1.FA C36_0.DG C40_1.TG C40_0.DG C52_0.TG C40_5.DG C22_4.FA C42_0.DG C22_2.FA C42_1.DG C20_3.FA C58_0.TG C40_4.DG C44_4.TG C42_2.DG C42_0.TG C48_0.TG C60_0.TG C40_0.TG C56_0.TG C50_0.TG C44_1.DG C34_0.DG C42_1.TG C44_2.DG C60_2.TG C56_1.TG C60_1.TG C22_1.FA C46_0.TG C44_1.TG C58_1.TG C40_6.DG C46_3.TG C52_1.TG C62_1.TG C62_5.TG C62_3.TG C22_6.FA C44_3.TG C62_2.TG C54_1.TG C62_4.TG C50_1.TG C48_1.TG C58_2.TG C42_2.TG C44_0.TG C46_1.TG C60_4.TG C54_0.TG C52_3.TG C64_1.TG C54_2.TG C52_2.TG C56_2.TG C60_3.TG C58_3.TG C48_4.TG C56_3.TG C46_2.TG C50_2.TG C46_4.TG C18_1.MG C64_2.TG C40_7.DG C64_3.TG C44_2.TG C54_4.TG C22_3.FA C48_2.TG C54_3.TG ID C28_1.PA C30_2.aPC C36_0.aPC C72_4.CL C44_8.aPE C46_9.aPE C46_8.aPE C36_5.aPC C40_9.PI C38_7.aPC C40_8.aPC C28_1.PE C42_7.aPC C40_6.aPE C30_1.aPC C42_1.PE C36_6.aPC C36_1.aPE C40_8.PI C38_0.PI C42_7.PC C40_5.aPE C18_0.LPC C14_1.aLPC C16_1.aLPC C38_6.aPC C40_3.aPE C18_2.aLPC C36_1.PC C38_6.PC C70_3.CL C42_4.PC C26_0.PC C70_4.CL C40_8.PC C40_6.PE C74_8.CL C40_1.PE C40_5.aPC C40_3.PC C42_5.PS C40_7.PC C46_5.aPE C40_2.PC C40_7.aPC C44_5.PC C40_6.PC C38_6.aPE C40_4.PI C40_6.PI C26_0.aPC C40_5.PC C42_6.aPC C40_3.PE C40_5.PI C38_1.PG C42_6.PE C42_8.PE C42_5.PI C42_5.PC C40_4.PE C38_4.aPE C44_7.PC C40_1.aPC C16_2.aLPC C42_6.PC C72_7.CL C40_6.aPC C40_4.PC C40_3.PI C38_2.PC C36_4.aPE C38_3.aPE C40_4.aPE C40_6.PS C42_6.PI C42_7.aPE C46_7.aPE C44_7.aPE C46_6.aPE C42_6.aPE C44_6.aPE C36_0.PA C72_5.CL C22_1.aLPC C42_5.aPE C74_7.CL C42_8.aPE C44_5.aPE C74_5.CL C20_1.aLPC C40_9.PE C38_1.PC C42_6.PS C72_6.CL C38_5.aPE C40_7.aPE C42_4.aPE C40_8.aPE C28_0.LPC C38_7.aPE C36_5.aPE C40_9.aPE C12_0.LPC C40_5.PA C32_1.PA C34_1.PA C40_0.PS C20_4.LPC C40_6.PA C42_6.PA C32_2.PA C38_4.PA C34_3.aPC C36_4.aPC C40_3.aPC C36_6.PC C42_4.aPC C42_3.PE C34_0.PC C38_1.aPC C38_6.PE C38_2.aPC C40_2.aPC C20_1.LPC C70_5.CL C38_3.PC C36_6.aPE C42_7.PE C42_2.PE C44_6.PC C28_0.PE C66_3.CL C38_7.PC C40_5.PE C38_2.aPE C36_1.aPC C40_2.PE C42_9.PE C40_5.PS C42_1.PS C74_9.CL C36_1.PG C38_3.aPC C42_4.PI C24_0.LPC C38_3.PA C70_6.CL C20_2.LPC C38_2.PE C36_3.aPE C40_7.PI C42_5.aPC C42_4.PE C42_2.PS C18_1.aLPC C74_6.CL C38_1.PE C42_7.PI C28_0.PC C38_5.aPC C38_4.aPC C72_8.CL C42_5.PE C40_4.aPC C34_0.PI C20_0.LPC C34_1.PG C38_6.PI C38_3.PI C34_0.aPC C34_0.PA C38_3.PE C38_4.PI C38_4.PE C38_1.PI C34_1.PC C40_2.PI C26_1.LPC C30_0.PC C36_2.aPC C36_4.PI C36_3.aPC C18_3.aLPC C36_6.PE C38_4.PC C36_2.aPE C40_1.PS C36_1.PA C38_5.PC C40_7.PE C42_4.PS C38_2.PI C40_7.PG C36_1.PS C68_4.CL C40_8.PE C38_1.PS C36_4.PC C40_3.PA C38_5.PE C36_4.PE C28_1.aPE C28_0.aPC C70_7.CL C40_7.PS C36_1.PI C40_2.PS C66_4.CL C36_2.PS C62_3.CL C16_0.LPA C32_1.PC C36_3.PE C30_0.aPC C66_5.CL C38_2.PS C30_1.PE C34_1.aPE C38_7.PE C32_1.PI C22_0.aLPC C28_0.PA C30_0.PA C36_5.PE C34_4.aPE C38_3.PS C68_6.CL C34_1.PE C36_2.PI C34_0.PE C28_2.aPE C28_1.PC C36_0.PE C34_1.PS C36_3.PI C32_2.aPC C24_1.LPC C32_0.PG C68_5.CL C36_3.PC C68_3.CL C64_3.CL C16_0.LPC C30_0.PG C34_1.PI C34_0.PS C36_0.PI C36_5.PI C32_0.PI C38_2.PA C34_2.aPC C38_5.PI C36_2.PC C36_1.PE C36_5.PC C32_0.PA C32_0.PE C66_2.CL C32_0.PC C30_0.PE C38_3.PG C38_5.PG C40_4.PG C38_4.PG C40_5.PG C30_1.PA C42_7.PA C16_1.LPC C36_0.PG C36_2.PG C32_3.PC C40_3.PG C34_2.PA C26_1.aLPC C38_2.PG C34_1.aPC C30_1.PC C18_1.LPC C36_2.PE C32_0.PS C40_4.PS C34_2.PC C40_3.PS C32_1.aPC C64_4.CL C16_0.aLPC C32_1.PG C36_3.PS C18_0.LPA C32_1.PE C38_5.PS C34_2.PI C34_3.aPE C30_0.PI C30_1.PI C32_2.PE C32_0.aPE C14_0.aLPC C34_3.PE C42_5.PA C30_0.aPE C20_0.aLPC C34_3.PS C30_1.PG C38_4.PS C40_6.PG C34_2.PS C32_2.PI C32_1.PS C34_3.PI C18_1.LPA C34_4.PE C34_2.PE C34_2.aPE C34_2.PG C36_5.PG C34_3.PC C40_4.PA C32_0.aPC C36_2.PA C32_2.PG C22_2.aLPC C18_2.LPC C32_1.aPE C34_4.PC C24_0.aLPC C38_6.PS C30_2.aPE C32_2.PC C32_2.aPE C38_7.PG C20_3.LPC C28_0.PS C30_0.PS C36_4.PG C24_1.aLPC C30_1.PS C14_0.LPC C34_0.PG C34_3.PG C30_2.PC C36_4.PS C36_3.PA C30_1.aPE C36_3.PG C38_6.PG ID C40_7.DG C54_6.TG C54_7.TG C34_3.DG C38_0.TG C16_0.FA C56_7.TG C36_0.aDG C56_8.TG C58_8.TG C38_4.DG C38_5.DG C16_0.FaCN C20_4.FA C34_2.DG C58_9.TG C18_0.FA C40_5.aDG C14_1.FA C34_4.aDG C40_7.aDG C36_5.aDG C38_5.aDG C34_3.aDG C36_3.aDG C40_6.aDG C38_4.aDG C38_6.aDG C16_1.MG C54_4.TG C50_4.TG C52_6.TG C32_2.DG C36_3.DG C38_1.TG C40_6.DG C54_5.TG C18_0.FaCN C38_6.DG C58_7.TG C52_7.TG C52_5.TG C56_6.TG C52_4.TG C14_0.FA C30_2.aDG C38_2.aDG C22_1.FA C40_5.DG C18_2.MG C16_0.MG C38_3.DG C50_3.TG C30_1.aDG C36_2.DG C50_5.TG C48_4.TG C52_3.TG C48_3.TG C56_5.TG C36_1.aDG C52_2.TG C56_4.TG C42_2.DG C48_2.TG C50_2.TG C40_3.DG C54_3.TG C58_6.TG C36_1.DG C18_1.MG C40_4.DG C46_3.TG C50_6.TG C34_1.aDG C48_1.TG C54_2.TG C44_2.DG C46_2.TG C42_0.DG C32_0.DG C50_1.TG C34_1.DG C40_1.DG C58_5.TG C38_2.DG C56_3.TG C58_4.TG C40_0.DG C60_0.TG C46_1.TG C42_2.TG C52_1.TG C42_0.TG C54_0.TG C32_0.aDG C48_0.TG C60_4.TG C64_2.TG C40_1.TG C62_4.TG C50_0.TG C56_2.TG C58_3.TG C60_3.TG C44_2.TG C46_0.TG C60_1.TG C34_0.DG C38_1.DG C42_1.DG C58_1.TG C56_1.TG C62_5.TG C52_0.TG C62_1.TG C58_0.TG C62_2.TG C44_1.TG C54_1.TG C40_2.TG C58_2.TG C44_0.TG C60_2.TG C62_3.TG C56_0.TG C30_0.DG C42_1.TG C20_2.FA C40_2.DG C44_1.DG C30_1.DG C34_0.aDG C64_3.TG C40_0.TG C44_3.TG C32_1.DG C20_1.FA C22_2.FA C24_1.FA C46_4.TG C20_3.FA C26_1.FA C26_0.FA C38_3.aDG C18_0.MG C22_3.FA C22_4.FA C18_2.FA C36_2.aDG C32_3.aDG C32_2.aDG C34_2.aDG C36_4.aDG C42_3.TG C24_0.FA C18_1.FA C22_6.FA C16_1.FA C32_1.aDG C22_5.FA C36_0.DG ID Neutral Lipids Control 0.3μM 3μM Phospholipids Control 0.3μM 3μM Neutral Lipids Control 0.1μM 0.3μM C38_1.TG C30_2.aDG C38_3.aDG C40_5.aDG C18_0.FaCN C32_1.aDG C36_5.aDG C18_0.FA C38_5.aDG C38_4.aDG C40_7.aDG C32_2.aDG C14_1.FA C38_6.aDG C16_0.FA C34_2.DG C34_3.DG C30_1.DG C38_4.DG C40_6.aDG C32_1.DG C32_0.aDG C32_2.DG C36_2.aDG C14_0.FA C16_1.FA C36_4.DG C38_0.TG C34_3.aDG C36_4.aDG C30_1.aDG C34_1.aDG C34_2.aDG C36_3.aDG C18_1.FA C36_1.aDG C16_0.FaCN C18_2.FA C38_2.aDG C40_2.TG C32_3.aDG C38_3.DG C24_1.FA C36_0.aDG C38_2.DG C40_3.DG C16_0.MG C36_1.DG C34_0.aDG C20_4.FA C18_0.MG C26_0.FA C32_0.DG C36_2.DG C18_2.MG C42_3.TG C34_1.DG C38_5.DG C16_1.MG C24_0.FA C36_3.DG C34_4.aDG C30_0.DG C56_8.TG C52_5.TG C54_7.TG C56_7.TG C58_7.TG C58_8.TG C48_3.TG C50_4.TG C52_7.TG C56_4.TG C52_4.TG C54_5.TG C56_5.TG C58_6.TG C50_5.TG C58_5.TG C20_2.FA C56_6.TG C58_4.TG C54_6.TG C50_3.TG C52_6.TG C50_6.TG C58_9.TG C20_1.FA C62_0.TG C22_5.FA C38_6.DG C40_1.DG C38_1.DG C40_2.DG C26_1.FA C36_0.DG C40_1.TG C40_0.DG C52_0.TG C40_5.DG C22_4.FA C42_0.DG C22_2.FA C42_1.DG C20_3.FA C58_0.TG C40_4.DG C44_4.TG C42_2.DG C42_0.TG C48_0.TG C60_0.TG C40_0.TG C56_0.TG C50_0.TG C44_1.DG C34_0.DG C42_1.TG C44_2.DG C60_2.TG C56_1.TG C60_1.TG C22_1.FA C46_0.TG C44_1.TG C58_1.TG C40_6.DG C46_3.TG C52_1.TG C62_1.TG C62_5.TG C62_3.TG C22_6.FA C44_3.TG C62_2.TG C54_1.TG C62_4.TG C50_1.TG C48_1.TG C58_2.TG C42_2.TG C44_0.TG C46_1.TG C60_4.TG C54_0.TG C52_3.TG C64_1.TG C54_2.TG C52_2.TG C56_2.TG C60_3.TG C58_3.TG C48_4.TG C56_3.TG C46_2.TG C50_2.TG C46_4.TG C18_1.MG C64_2.TG C40_7.DG C64_3.TG C44_2.TG C54_4.TG C22_3.FA C48_2.TG C54_3.TG ID PC3 Neutral Lipids Control 0.3μM 3μM PC3 S. C60_1.TG C54_0.TG C64_1.TG C56_3.TG C58_0.TG C62_0.TG C58_1.TG C58_3.TG C50_3.TG C64_2.TG C40_0.TG C42_0.TG C42_1.TG C44_3.TG C54_5.TG C40_1.TG C44_4.TG C46_3.TG C40_0.DG C38_0.TG C40_1.DG C42_1.DG C64_3.TG C50_4.TG C30_0.DG C50_5.TG C54_1.TG C56_1.TG C46_4.TG C50_6.TG C62_4.TG C56_5.TG C56_2.TG C48_1.TG C58_5.TG C58_8.TG C46_0.TG C62_3.TG C56_0.TG C48_2.TG C56_6.TG C50_1.TG C54_6.TG C52_1.TG C58_4.TG C52_5.TG C54_7.TG C48_0.TG C56_8.TG C36_0.aDG C58_2.TG C32_0.DG C56_4.TG C50_2.TG C52_4.TG C54_4.TG C62_5.TG C40_2.TG C58_9.TG C48_4.TG C42_3.TG C52_6.TG C42_2.TG C44_0.TG C56_7.TG C44_1.TG C48_3.TG C52_7.TG C38_1.TG C44_2.TG C58_6.TG C42_0.DG C58_7.TG C46_1.TG C46_2.TG C34_0.DG C50_0.TG C62_1.TG C54_2.TG C60_2.TG C60_4.TG C32_0.aDG C52_3.TG C60_0.TG C60_3.TG C62_2.TG C52_0.TG C34_0.aDG C52_2.TG C32_2.aDG C18_2.MG C34_1.aDG C34_2.aDG C36_0.DG C24_0.FA C38_6.DG C16_0.MG C36_3.aDG C38_1.DG C18_0.MG C36_1.aDG C18_1.MG C36_1.DG C54_3.TG C32_1.aDG C34_3.aDG C30_1.aDG C36_4.aDG C22_2.FA C22_1.FA C40_3.DG C44_1.DG C20_2.FA C20_3.FA C22_3.FA C20_4.FA C34_4.aDG C42_2.DG C18_0.FaCN C20_1.FA C40_7.aDG C22_4.FA C44_2.DG C40_6.DG C30_2.aDG C22_6.FA C40_5.DG C18_0.FA C38_5.DG C22_5.FA C40_2.DG C18_1.FA C26_1.FA C30_1.DG C38_2.DG C32_3.aDG C36_2.DG C18_2.FA C24_1.FA C38_3.DG C38_4.DG C14_1.FA C16_0.FA C32_2.DG C32_1.DG C36_2.aDG C34_1.DG C40_7.DG C26_0.FA C38_6.aDG C38_4.aDG C38_5.aDG C38_3.aDG C36_3.DG C14_0.FA C16_0.FaCN C16_1.FA C34_2.DG C16_1.MG C34_3.DG C40_6.aDG C36_5.aDG C40_4.DG C38_2.aDG C40_5.aDG ID C36_0.PI C14_1.aLPC C16_0.LPA C40_0.PS C38_0.PI C30_1.PA C18_0.LPA C40_3.PA C40_4.PA C34_0.PA C28_0.PA C30_0.PA C32_0.PA C26_0.PC C26_0.PA C32_2.PA C16_2.aLPC C40_5.PE C28_1.PA C36_0.PA C16_0.aLPC C44_6.aPE C40_1.PE C42_1.PE C42_4.PC C36_4.aPC C36_5.aPC C40_3.aPC C28_0.PC C42_6.PC C20_0.LPC C32_0.PI C18_0.LPC C40_4.aPC C36_1.aPE C44_6.PC C36_6.PE C30_0.PI C30_2.aPC C34_1.PA C34_2.PA C38_7.aPC C36_3.PA C44_7.PC C32_1.PA C42_5.PA C36_0.PE C34_0.PC C42_6.PS C20_2.LPC C20_3.LPC C42_9.PE C42_7.PI C14_0.LPC C30_1.PS C20_4.LPC C34_3.PS C38_4.PA C40_8.PI C16_1.LPC C18_3.aLPC C28_1.PE C62_3.CL C42_7.PE C34_4.PC C74_8.CL C18_1.LPC C18_2.LPC C36_4.PS C28_0.PE C40_3.PG C40_4.PG C38_7.PG C38_5.PS C70_5.CL C40_8.PC C40_9.aPE C38_7.PC C40_5.PG C40_9.PI C72_6.CL C34_4.PE C40_7.PG C42_8.PE C40_6.PG C42_6.PA C74_7.CL C30_0.PE C38_3.PS C42_8.aPE C72_7.CL C44_7.aPE C40_7.PE C66_5.CL C32_1.PE C70_3.CL C42_4.PI C74_6.CL C30_2.PC C70_6.CL C20_1.LPC C28_0.LPC C38_6.PG C72_8.CL C42_5.aPE C40_9.PE C72_5.CL C34_1.PE C68_5.CL C30_1.PE C74_9.CL C16_1.aLPC C38_6.PS C70_7.CL C42_6.PE C66_4.CL C38_2.PS C38_1.PG C38_4.PG C40_6.PA C38_5.PG C32_2.PE C34_2.PS C36_5.PI C68_6.CL C38_2.PG C36_1.PS C32_2.PI C40_6.PS C40_7.PS C38_3.PG C70_4.CL C36_2.PA C68_4.CL C34_3.PI C38_4.PS C66_2.CL C34_1.PS C40_4.PS C34_3.PC C36_2.PS C42_6.aPC C12_0.LPC C42_2.PS C66_3.CL C32_0.PE C34_1.PG C36_4.PG C32_1.PS C18_1.aLPC C30_2.aPE C36_4.PI C64_4.CL C34_2.PE C16_0.LPC C42_4.PE C36_6.aPE C38_4.aPC C24_0.aLPC C36_3.aPC C38_3.aPE C30_1.aPC C36_4.aPE C18_1.LPA C38_6.aPC C38_5.aPC C40_5.PA C38_2.aPC C28_1.PC C40_4.PE C38_2.aPE C40_3.PE C38_6.PE C38_4.PE C38_4.aPE C36_2.aPC C68_3.CL C36_6.aPC C42_2.PE C42_5.PI C30_0.PC C42_4.aPC C38_1.aPC C40_7.aPC C34_1.aPE C40_8.aPC C42_6.PI C40_6.aPC C74_5.CL C20_1.aLPC C38_3.aPC C40_5.aPC C40_3.PC C38_3.PE C38_3.PA C40_6.PC C42_3.PE C40_5.PC C38_5.PE C42_5.PS C42_5.PC C32_1.aPC C40_7.PI C36_4.PE C34_0.PI C38_4.PC C38_1.PE C38_1.PC C38_6.PC C22_0.aLPC C30_0.PG C38_2.PE C42_5.PE C26_0.aPC C40_1.aPC C44_5.PC C30_0.aPC C40_2.PC C34_1.aPC C40_2.PE C40_4.PC C36_2.aPE C32_2.aPC C34_2.aPC C40_5.PI C40_4.PI C34_0.PS C40_6.PI C42_7.PC C36_5.aPE C36_5.PE C32_0.PC C38_3.PC C36_1.aPC C36_3.aPE C30_1.PC C32_2.aPE C36_3.PE C40_8.PE C36_6.PC C38_3.PI C40_2.PS C32_1.PI C36_3.PI C24_0.LPC C30_0.aPE C42_7.aPC C36_2.PI C34_0.aPC C36_1.PG C34_2.PC C40_2.aPC C26_1.LPC C40_1.PS C28_1.aPE C42_7.aPE C24_1.LPC C42_4.aPE C34_1.PI C34_1.PC C34_3.PE C34_2.PI C34_3.PG C32_1.PC C34_2.PG C40_7.PC C36_2.PE C40_3.PS C36_3.PG C32_2.PG C36_3.PS C34_0.PG C40_6.aPE C32_2.PC C40_7.aPE C28_2.aPE C38_2.PI C42_6.aPE C38_1.PS C40_8.aPE C40_5.PS C36_2.PG C30_1.PI C36_5.PG C20_0.aLPC C36_0.PG C72_4.CL C34_3.aPC C42_4.PS C32_0.aPC C40_3.aPE C40_3.PI C34_4.aPE C38_5.PC C28_0.aPC C38_7.PE C32_0.PG C38_5.aPE C38_2.PA C32_0.aPE C38_5.PI C32_0.PS C14_0.aLPC C64_3.CL C30_1.PG C42_5.aPC C36_1.PI C34_2.aPE C38_6.aPE C36_5.PC C36_1.PC C32_1.aPE C44_8.aPE C40_2.PI C36_3.PC C38_2.PC C22_2.aLPC C38_7.aPE C40_5.aPE C30_0.PS C34_3.aPE C36_1.PA C38_6.PI C36_4.PC C42_7.PA C32_3.PC C32_1.PG C28_0.PS C38_1.PI C44_5.aPE C42_1.PS C38_4.PI C34_0.PE C36_1.PE C40_6.PE C40_4.aPE C30_1.aPE C36_2.PC C18_2.aLPC ID C38_1.TG C30_2.aDG C38_3.aDG C40_5.aDG C18_0.FaCN C32_1.aDG C36_5.aDG C18_0.FA C38_5.aDG C38_4.aDG C40_7.aDG C32_2.aDG C14_1.FA C38_6.aDG C16_0.FA C34_2.DG C34_3.DG C30_1.DG C38_4.DG C40_6.aDG C32_1.DG C32_0.aDG C32_2.DG C36_2.aDG C14_0.FA C16_1.FA C36_4.DG C38_0.TG C34_3.aDG 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C48_1.TG C58_2.TG C42_2.TG C44_0.TG C46_1.TG C60_4.TG C54_0.TG C52_3.TG C64_1.TG C54_2.TG C52_2.TG C56_2.TG C60_3.TG C58_3.TG C48_4.TG C56_3.TG C46_2.TG C50_2.TG C46_4.TG C18_1.MG C64_2.TG C40_7.DG C64_3.TG C44_2.TG C54_4.TG C22_3.FA C48_2.TG C54_3.TG ID C28_1.PA C30_2.aPC C36_0.aPC C72_4.CL C44_8.aPE C46_9.aPE C46_8.aPE C36_5.aPC C40_9.PI C38_7.aPC C40_8.aPC C28_1.PE C42_7.aPC C40_6.aPE C30_1.aPC C42_1.PE C36_6.aPC C36_1.aPE C40_8.PI C38_0.PI C42_7.PC C40_5.aPE C18_0.LPC C14_1.aLPC C16_1.aLPC C38_6.aPC C40_3.aPE C18_2.aLPC C36_1.PC C38_6.PC C70_3.CL C42_4.PC C26_0.PC C70_4.CL C40_8.PC C40_6.PE C74_8.CL C40_1.PE C40_5.aPC C40_3.PC C42_5.PS C40_7.PC C46_5.aPE C40_2.PC C40_7.aPC C44_5.PC C40_6.PC C38_6.aPE C40_4.PI C40_6.PI C26_0.aPC C40_5.PC C42_6.aPC C40_3.PE C40_5.PI C38_1.PG C42_6.PE C42_8.PE C42_5.PI C42_5.PC C40_4.PE C38_4.aPE C44_7.PC C40_1.aPC C16_2.aLPC C42_6.PC C72_7.CL C40_6.aPC C40_4.PC C40_3.PI C38_2.PC C36_4.aPE C38_3.aPE C40_4.aPE C40_6.PS C42_6.PI C42_7.aPE C46_7.aPE 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C54_6.TG C56_6.TG C58_6.TG C18_0.MG C58_2.TG ID C36_1.PA C70_4.CL C28_2.aPE C44_5.aPE C36_4.PS C40_6.PI C36_2.PE C36_3.PS C68_5.CL C40_6.PA C42_1.PS C36_5.PI C34_4.aPE C30_1.PC C68_4.CL C36_1.PG C34_2.PS C38_4.PA C40_5.aPE C42_6.PA C38_3.PG C38_3.PI C74_7.CL C74_9.CL C38_2.PS C34_3.PI C38_5.aPE C38_6.PG C38_7.PC C36_3.PI C34_3.PG C72_6.CL C38_1.PS C38_4.PG C40_3.PS C36_1.PS C72_5.CL C36_2.PI C72_7.CL C40_1.PS C74_6.CL C68_6.CL C40_7.PS C34_2.PI C70_6.CL C72_8.CL C36_4.PG C36_2.PS C42_2.PS C40_9.PI C36_4.PI C28_0.PS C30_0.PS C40_9.PE C42_7.PC C28_1.aPE C70_7.CL C74_5.CL C38_3.PS C36_5.PG C38_2.PG C36_2.PA C34_2.PG C34_2.aPE C70_5.CL C38_6.PI C38_4.PS C72_4.CL C40_4.PC C20_3.LPC C44_6.aPE C38_3.PC C38_4.PC C20_4.LPC C18_2.LPC C20_2.LPC C40_7.PI C38_6.PC C40_9.aPE C36_3.PC C32_1.PC C42_8.aPE C36_4.PC C36_2.PC C40_7.aPE C34_2.PC C40_8.aPE C34_1.PC C40_5.PC C18_1.LPC C12_0.LPC C42_8.PE C44_8.aPE C32_2.PC C42_6.aPE C42_9.PE C38_5.PC C42_7.aPE C16_1.LPC C38_7.PG C40_6.aPE C40_7.PG C40_8.PE 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C36_3.PS C74_8.CL C30_1.PS C36_5.PC C32_2.aPC C38_5.PI C40_8.PC C34_1.PE C42_7.aPE C38_4.PA C34_0.PC C28_1.PE C40_5.PA C36_1.PC C20_1.aLPC C38_4.PC C42_4.PE C38_6.PS C32_0.PC C44_7.aPE C38_4.PI C36_2.PC C38_5.PC C36_3.PC C42_6.aPE C36_4.PC C38_6.PC C40_6.aPE C40_8.PE C40_8.aPE C34_0.PI C20_0.aLPC C40_9.PI C30_2.aPC C68_3.CL C34_3.aPE C38_1.PC C40_6.PE C34_4.PE C30_0.PC C34_2.aPE C36_2.PA C40_7.PC C36_1.PE C40_2.PI C32_2.PA C38_3.PC C40_6.PC C18_3.aLPC C40_5.PC C34_2.PE C38_2.PC C40_4.PC C28_1.PC C36_2.PE C42_5.PI C38_3.PA C44_5.aPE C38_6.PI C18_1.aLPC C40_5.PS C18_2.aLPC C40_3.PI C32_0.aPE C34_3.PS C16_2.aLPC C32_2.PE C36_0.PG C30_2.PC C30_1.PG C38_1.PI C24_0.LPC C28_0.LPC C32_1.PE C64_3.CL C14_0.LPC C40_4.PG C32_1.PS C32_2.PG C38_1.PG C64_4.CL C62_3.CL C66_2.CL C32_0.PG C32_1.PG C24_1.LPC C34_0.PG C36_6.aPC C42_6.PA C40_3.PG C32_1.aPE C42_4.aPE C16_0.aLPC C34_0.PE C38_1.aPC C32_0.PI C36_0.PI C32_2.aPE C36_0.PA C38_3.aPC C40_2.aPC C40_1.aPC C38_2.aPC C30_0.PI C44_6.PC C34_0.PA C30_0.aPC C38_0.PI C36_1.aPC C34_1.aPE C36_0.PE C20_0.LPC C40_3.PA C40_3.aPE C36_4.aPC C30_2.aPE C26_0.PA C36_1.aPE C16_0.LPA C40_3.aPC C26_0.PC C32_0.PA C38_3.aPE C36_6.PC C30_0.PA C38_4.aPC C38_4.aPE C40_6.aPC C18_0.LPA C42_1.PE C28_1.PA C36_2.aPC C38_7.aPC C42_3.PE C38_2.aPE C40_0.PS C36_6.aPE C30_1.PA C38_6.aPC C40_4.aPC C38_5.aPC C42_5.aPC C14_0.aLPC C36_3.aPC C28_0.PA C44_7.PC C40_4.PA C32_1.aPC C40_1.PE C42_5.PA C40_8.aPC C42_6.PC C32_0.aPC ID C38_1.TG C44_4.TG C16_0.MG C44_2.DG C38_1.DG C42_0.TG C34_0.aDG C34_0.DG C40_0.TG C58_1.TG C18_1.MG C56_0.TG C56_1.TG C40_1.DG C60_2.TG C62_3.TG C54_0.TG C48_0.TG C50_0.TG C32_0.DG C40_2.TG C30_0.DG C58_2.TG C46_0.TG C26_0.FA C44_0.TG C42_0.DG C36_0.aDG C42_1.TG C46_4.TG C62_1.TG C58_0.TG C44_3.TG C44_1.DG C64_3.TG C42_2.DG C60_1.TG C40_0.DG C62_2.TG C42_2.TG C40_1.TG C42_1.DG C52_0.TG C18_2.MG C64_2.TG C22_1.FA C54_3.TG C20_2.FA C50_3.TG C48_3.TG C38_3.DG C56_4.TG C18_0.FA C24_0.FA C36_3.DG C58_5.TG C38_6.DG C54_4.TG C40_4.DG C52_6.TG C50_4.TG C50_5.TG C16_1.FA C38_5.DG C56_6.TG C16_1.MG C14_1.FA C38_2.aDG C36_1.aDG C32_1.aDG C38_0.TG C58_6.TG C24_1.FA C54_5.TG C40_5.DG C18_1.FA C22_2.FA C30_1.aDG C52_5.TG C56_5.TG C32_2.DG C52_4.TG C34_1.DG C20_1.FA C38_2.DG C58_3.TG C32_0.aDG C60_4.TG C46_2.TG C50_1.TG C56_2.TG C62_4.TG C44_1.TG C60_3.TG C30_1.DG C46_3.TG C44_2.TG C52_1.TG C62_5.TG C46_1.TG C54_1.TG C40_2.DG C48_1.TG C32_1.DG C36_1.DG C26_1.FA C52_7.TG C48_4.TG C48_2.TG C54_2.TG C52_2.TG C50_2.TG C56_3.TG C40_3.DG C14_0.FA C50_6.TG C52_3.TG C16_0.FA C34_2.DG C36_4.DG C58_4.TG C34_4.aDG C36_2.DG C18_0.MG C30_2.aDG C36_0.DG C36_3.aDG C20_3.FA C40_6.DG C38_3.aDG C38_4.DG C18_2.FA C34_3.aDG C22_4.FA C34_3.DG C54_6.TG C22_3.FA C34_1.aDG C36_4.aDG C36_2.aDG C34_2.aDG C38_4.aDG C40_7.aDG C40_6.aDG C58_7.TG C22_6.FA C18_0.FaCN C40_5.aDG C22_5.FA C54_7.TG C32_2.aDG C40_7.DG C56_7.TG C32_3.aDG C38_5.aDG C20_4.FA C38_6.aDG C16_0.FaCN C58_9.TG C56_8.TG C36_5.aDG C58_8.TG ID C40_2.PE C70_5.CL C38_3.PA C68_3.CL C30_1.aPE C36_3.aPE C38_6.PS C20_1.LPC C40_6.PS C74_9.CL C40_5.PI C40_3.PC C70_6.CL C38_2.PE C38_7.PE C36_4.aPE C32_0.PE C38_2.aPE C34_1.PE C74_7.CL C74_5.CL C30_1.PS C44_8.aPE C68_5.CL C34_0.PI C40_9.aPE C40_1.PS C42_7.PC C36_3.PE C46_7.aPE C40_2.PC C16_2.aLPC C42_5.PS C36_3.PI C36_1.PG C38_6.aPE C36_3.PA C70_7.CL C36_4.PI C42_5.PA C40_7.PC C40_5.PS C32_0.PS C38_2.PG C40_3.PG C32_2.PI C36_2.PA C40_4.PC C16_0.aLPC C42_5.aPC C32_2.PE C42_4.PS C40_6.aPC C34_1.PS C34_3.aPE C38_3.PI C34_0.PC C40_3.aPC C38_2.PC C30_1.aPC C26_1.aLPC C34_4.PE C28_0.PS C30_0.PS C40_5.aPC C40_7.PS C34_2.PE C36_2.PE C74_6.CL C32_1.PS C40_8.aPC C36_2.aPE C34_2.PI C38_1.PE C36_2.PI C40_5.PC C34_1.aPE C34_1.PG C34_4.aPE C70_4.CL C38_1.PI C40_3.aPE C30_0.PA C36_6.PE C72_4.CL C72_8.CL C44_5.PC C66_5.CL C42_1.PE C30_0.PG C32_1.PI C64_4.CL C28_1.PC C40_6.aPE C30_1.PE C28_0.PE C42_3.PE C42_5.PI C68_6.CL C40_1.aPC C66_3.CL C42_4.aPC C42_2.PE C42_6.aPE C44_6.PC C34_0.aPC C28_0.PC C64_3.CL C42_5.aPE C42_6.PS C40_4.aPE C40_5.aPE C38_6.PE C40_5.PE C38_3.aPE C46_5.aPE C46_9.aPE C72_7.CL C38_4.aPE C30_1.PI C32_1.PG C40_4.PA C42_7.aPC C36_4.PE C38_2.PI C34_1.PI C46_6.aPE C38_1.PC C44_5.aPE C36_0.PI C40_4.PE C34_1.PA C66_4.CL C40_7.aPE C18_3.aLPC C36_1.aPE C38_7.aPE C38_6.PI C40_3.PE C42_7.aPE C38_4.PE C30_0.PC C38_5.aPE C42_2.PS C42_7.PI C72_5.CL C30_0.PE C32_0.aPE C14_1.aLPC C36_5.PE C32_0.PG C40_1.PE C42_1.PS C40_8.aPE C40_6.PI C40_3.PI C44_7.PC C40_4.PI C40_7.PI C42_4.PC C46_8.aPE C42_6.PC C36_1.PI C42_6.aPC C38_0.PI C74_8.CL C30_0.aPE C38_5.PE C44_6.aPE C38_3.PE C42_8.aPE C26_0.aPC C72_6.CL C44_7.aPE C42_5.PC C68_4.CL C32_1.PE C38_1.PG C16_1.aLPC C22_0.aLPC C40_3.PA C40_2.aPC C24_0.aLPC C20_1.aLPC C40_8.PE C42_9.PE C66_2.CL C26_0.PC C40_7.PE C24_1.LPC C42_6.PE C42_4.PE C30_1.PG C26_1.LPC C42_5.PE C40_2.PI C40_6.PE C70_3.CL C42_7.PE C42_8.PE C32_0.PI C42_6.PI C32_1.PA C62_3.CL C24_0.LPC C34_0.PA C32_0.PA C30_0.PI C42_4.PI C20_0.LPC C42_4.aPE C18_1.LPA C32_2.PC C36_4.PG C40_6.PA C36_4.PC C38_4.PI C42_6.PA C38_5.PG C42_7.PA C38_5.PC C38_7.PC C36_4.aPC C34_3.PI C36_3.PG C40_7.PG C38_5.aPC C12_0.LPC C14_0.aLPC C34_3.PC C34_4.PC C36_5.aPC C38_6.aPC C40_5.PA C38_4.aPC C36_4.PS C40_6.PG C34_2.aPC C38_1.aPC C30_2.PC C36_2.aPC C34_3.PS C34_2.PG C34_2.PC C32_1.aPC C32_0.aPC C32_2.aPC C38_4.PC C38_4.PG C34_3.aPC C36_2.PG C38_6.PC C36_1.aPC C36_1.PA C36_3.aPC C36_3.PC C38_7.aPC C36_0.PE C34_2.PA C32_1.PC C32_2.PG C16_0.LPC C36_2.PC C14_0.LPC C40_5.PG C36_1.PS C34_0.PG C20_2.LPC C36_6.aPE C34_1.PC C38_5.PS C40_3.PS C40_4.aPC C38_4.PS C38_3.PG C30_2.aPC C38_5.PI C40_4.PS C38_2.PS C28_0.aPC C34_0.PE C34_2.PS C36_1.PC C40_4.PG C38_3.aPC C38_2.PA C38_3.PC C38_2.aPC C30_1.PC C38_1.PS C36_5.aPE C28_1.aPE C34_3.PE C36_3.PS C36_5.PI C30_2.aPE C36_0.PG C32_1.aPE C32_2.aPE C40_8.PC C18_0.LPC C32_0.PC C34_0.PS C38_3.PS C40_8.PI C34_2.aPE C36_1.PE C40_2.PS C36_2.PS C30_0.aPC C40_7.aPC C28_2.aPE C40_6.PC C16_0.LPA C20_0.aLPC C24_1.aLPC C20_3.LPC C20_4.LPC C18_2.aLPC C16_1.LPC C32_2.PA C38_7.PG C36_6.PC C18_2.LPC C36_5.PG C38_4.PA C18_1.aLPC C38_6.PG C36_5.PC C18_1.LPC C32_3.PC C34_3.PG ID hibition C. mTOR inhibition B. PI3k inhibition gure 4. Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. AKT, B. PI3K and C. mTOR tor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families, and lipids within family are sorted by name. 1 0.5 0 0.5 1 Neutral Lipids rol 0.3μM 3μM FA MG DG TG CL PS PI PG PA PC PE Neutral Lipids ol 0.3μM 3μM Phospholipids Control 0.3μM 3μM Phospholipids Control 0.3μM 3μM Neutral Lipids Control 0.1μM 0.3μM Phospholipids Control 0.1μM 0.3μM Neutral Lipids Control 0.1μM 0.3μM Phospholipids Control 0.1μM 0.3μM Neutral Lipids Control 0.1μM 1μM Phospholipids Control 0.1μM 1μM Phospholipids Control 0.1μM 1μM Neutral Lipids Control 0.1μM 1μM Neutral Lipids Phospholipids Fold Change Figure 4. Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. AKT, B. PI3K and C. mTOR inhibitor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families, and lipids within each family are sorted by name. p analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. AKT, B. PI3K and C. mTOR ons. All Lipids were compared against DMSO control. Side covariates indicate lipid families, and lipids within
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Figure S4 Figure S4
4
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Alternative_Cleavage_and_Polyadenylation_during_Colorectal_Cancer_Development/22452584/1/files/39903659.pdf
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4 R 3’UTR WT EGFR 3’UTR Mutant EGFR 3’UTR WT RW2982 SW620 Colo320 WT Mutant WT 3 6 9 12 /GAPDH 0.5 1.0 3 EGFR mRNA/ SW48 LIM2405 LIM1215 HCT116 HCA7 Caco-2 RW2982 SW620 Colo320 0.0 4 R 3’UTR WT EGFR 3’UTR Mutant EGFR 3’UTR WT RW2982 SW620 Colo320 WT Mutant WT 3 6 9 12 /GAPDH 0.5 1.0 3 EGFR mRNA/ SW48 LIM2405 LIM1215 HCT116 HCA7 Caco-2 RW2982 SW620 Colo320 0.0 R 3’UTR utant EGFR 3’UTR WT utant WT M1215 CT116 HCA7 Caco-2 W2982 SW620 lo320 R EG Colo320 3 6 9 12 /GAPDH 0.5 1.0 3 EGFR mRNA/ SW48 LIM2405 LIM 0.0
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https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_An_A13_Repeat_within_the_3_-Untranslated_Region_of_Epidermal_Growth_Factor_Receptor_EGFR_Is_Frequently_Mutated_in_Microsatellite_Instability_Colon_Cancers_and_Is_Associated_with_Increased_EGFR_Expression/22378871/1/files/39824231.pdf
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Supplementary Figure 4 Supplementary Figure 4 Supplementary Figure 4 Supplementary Figure 4 Bcl3 + Bcl3 5 Bcl3 + Bcl3 - TEB migration 1.3mm +/- 1.0 1.2mm +/- 1.3 week TEB migration 4.3mm +/- 0.8 4.7mm +/- 0.9 6 week 21 week Inter-branch interval 1.7 +/- 0.04 1.5 +/- 0.35 week Bcl3 + Bcl3 5 Bcl3 + Bcl3 - TEB migration 1.3mm +/- 1.0 1.2mm +/- 1.3 week TEB migration 4.3mm +/- 0.8 4.7mm +/- 0.9 6 week 21 week Inter-branch interval 1.7 +/- 0.04 1.5 +/- 0.35 week Bcl3 + Bcl3 5 Bcl3 + Bcl3 - TEB migration 1.3mm +/- 1.0 1.2mm +/- 1.3 week TEB migration 4.3mm +/- 0.8 4.7mm +/- 0.9 6 week 5 6 21
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Supplementary Fig. S4 A C B uptake (%) 70 60 50 40 ** * MKN1 * 70 60 50 40 (μM) MKN1 0 50 100 500 (μM) P-AMPK LC3-I 2-DG (12h) E Glucose u 30 20 10 0 0 1 5 10 (pmol) si-CAV1 0 1 5 10 (pmol) si-GLUT3 30 20 10 0 ATP LC3 I LC3-II Actin HCT116 MOCK D DAPI MitoTracker Merge i-Control si-Control si-CAV1 si si-CAV1 F p53+/+ p53-/- 0 5 10 0 5 10 si-CAV1 (pmol) HCT116 100 101 102 103 104 H GLUT3 CAV1 1 2 3 4 5 6 7 8 9 10 11 12 13 Pellet si-Control p53 GLUT3 CAV1 Actin CAV1 GLUT3 CAV1 si-CAV-1 G II Supplementary Fig. S4 A C B uptake (%) 70 60 50 40 ** * MKN1 * 70 60 50 40 (μM) MKN1 0 50 100 500 (μM) P-AMPK LC3-I 2-DG (12h) E Glucose u 30 20 10 0 0 1 5 10 (pmol) si-CAV1 0 1 5 10 (pmol) si-GLUT3 30 20 10 0 ATP LC3 I LC3-II Actin HCT116 MOCK D DAPI MitoTracker Merge i-Control si-Control si-CAV1 si si-CAV1 F p53+/+ p53-/- 0 5 10 0 5 10 si-CAV1 (pmol) HCT116 100 101 102 103 104 H GLUT3 CAV1 1 2 3 4 5 6 7 8 9 10 11 12 13 Pellet si-Control p53 GLUT3 CAV1 Actin CAV1 GLUT3 CAV1 si-CAV-1 G II B uptake (%) 70 60 50 40 ** * MKN1 Glucose u 30 20 10 0 0 1 5 10 (pmol) si-CAV1 A * 70 60 50 40 (μM) MKN1 0 1 5 10 (pmol) si-GLUT3 30 20 10 0 ATP Supplementary A C B uptake (%) 70 60 50 40 ** * MKN1 * 70 60 50 40 (μM) MKN1 0 50 100 500 (μM) P-AMPK LC3-I 2-DG (12h) Glucose u 30 20 10 0 0 1 5 10 (pmol) si-CAV1 0 1 5 10 (pmol) si-GLUT3 30 20 10 0 ATP LC3 I LC3-II Actin HCT116 Supplementary Fig. Supplementary Fig. S4 A C B uptake (%) 70 60 50 40 ** * MKN1 * 70 60 50 40 (μM) MKN1 0 50 100 500 (μM) P-AMPK LC3-I 2-DG (12h) E Glucose u 30 20 10 0 0 1 5 10 (pmol) si-CAV1 0 1 5 10 (pmol) si-GLUT3 30 20 10 0 ATP LC3 I LC3-II Actin HCT116 MOCK D DAPI MitoTracker Merge i-Control si-Control si-CAV1 si si-CAV1 F p53+/+ p53-/- 0 5 10 0 5 10 si-CAV1 (pmol) HCT116 100 101 102 103 104 H GLUT3 CAV1 1 2 3 4 5 6 7 8 9 10 11 12 13 Pellet si-Control p53 GLUT3 CAV1 Actin CAV1 GLUT3 CAV1 si-CAV-1 G II S4 C B A 0 50 100 500 (μM) P-AMPK LC3-I 2-DG (12h) LC3 I LC3-II Actin HCT116 E 0 0 1 5 10 (pmol) si-CAV1 0 1 5 10 (pmol) si-GLUT3 0 MOCK D DAPI MitoTracker Merge i-Control si-Control si-CAV1 si si-CAV1 F p53+/+ p53-/- 0 5 10 0 5 10 si-CAV1 (pmol) HCT116 100 101 102 103 104 H GLUT3 CAV1 1 2 3 4 5 6 7 8 9 10 11 12 13 Pellet si-Control p53 GLUT3 CAV1 Actin CAV1 GLUT3 CAV1 si-CAV-1 G I 0 1 5 10 GLUT9 (556 bp) GLUT10 (504 bp) GLUT11 (222 bp) GLUT1 (332 bp) GLUT2 (525 bp) GLUT4 (301 bp) 0 1 5 10 si-CAV1 (pmol) si-CAV1 (pmol) I p53+/+ p53-/- si-Control si-GLUT3 25 20 15 f cell (x 105) si-Control si-GLUT3 * ( p) GLUT12 (268 bp) GLUT13 (256 bp) GLUT14 (435 bp) GAPDH (343 bp) ( p) GLUT5 (440 bp) GLUT6 (416 bp) GLUT7 (581 bp) GLUT8 (471 bp) 0 1 2 3 4 5 Days after transfection ** 10 5 0 Number of E MOCK si-Control si-CAV1 100 101 102 103 104 E MOCK D DAPI MitoTracker Merge i-Control si-Control si-CAV1 si si-CAV1 E D DAPI MitoTracker Merge i-Control si-CAV1 si D si-CAV1 F GLUT3 CAV1 1 2 3 4 5 6 7 8 9 10 11 12 13 Pellet si-Control CAV1 GLUT3 CAV1 si-CAV-1 F p53+/+ p53-/- 0 5 10 0 5 10 si-CAV1 (pmol) HCT116 H p53 GLUT3 CAV1 Actin H G 0 1 5 10 GLUT9 (556 bp) GLUT10 (504 bp) GLUT11 (222 bp) GLUT1 (332 bp) GLUT2 (525 bp) GLUT4 (301 bp) 0 1 5 10 si-CAV1 (pmol) si-CAV1 (pmol) ( p) GLUT12 (268 bp) GLUT13 (256 bp) GLUT14 (435 bp) GAPDH (343 bp) ( p) GLUT5 (440 bp) GLUT6 (416 bp) GLUT7 (581 bp) GLUT8 (471 bp) G G II p53+/+ p53-/- si-Control si-GLUT3 25 20 15 f cell (x 105) si-Control si-GLUT3 * 0 1 2 3 4 5 Days after transfection ** 10 5 0 Number of II Days after transfection
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4 4 4
3
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Chromatin_Remodeling_Underlies_the_Senescence-Associated_Secretory_Phenotype_of_Tumor_Stromal_Fibroblasts_That_Supports_Cancer_Progression/22394648/1/files/39840260.pdf
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Supplemental Figure S4 A B C Supplemental Figure S4 A B C Supplemental Figure S4 A B Supplemental Figure S4 A A B B C C C
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A B A B A A B B
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https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_HER2-Associated_Radioresistance_of_Breast_Cancer_Stem_Cells_Isolated_from_HER2-Negative_Breast_Cancer_Cells/22451726/1/files/39902801.pdf
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1 6 1.8 ** ** sion 0.6 0.8 1.0 1.2 1.4 1.6 elative expres 1 2 0.0 0.2 0.4 HBEC HBEC KRasV12 HBEC KrasV12 SiRNA HBEC KrasV12 SiRNA TUBB3 re 1 6 1.8 ** ** sion 0.6 0.8 1.0 1.2 1.4 1.6 elative expres 1 2 0.0 0.2 0.4 HBEC HBEC KRasV12 HBEC KrasV12 SiRNA HBEC KrasV12 SiRNA TUBB3 re 2 12 HBEC KrasV12 SiRNA ** ** 1 2 HBEC KRasV12 HBEC KrasV12 SiRNA HBEC KrasV12 SiRNA ** 1 HBEC KRasV12 HBEC Kras SiRNA 1 6 1.8 ** sion 0.6 0.8 1.0 1.2 1.4 1.6 elative expres 0.0 0.2 0.4 HBEC TUBB3 re
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309
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Identification_of_Small-Molecule_Inhibitors_of_the_Colorectal_Cancer_Oncogene_Kr_ppel-like_Factor_5_Expression_by_Ultrahigh-Throughput_Screening/22496779/1/files/39954805.pdf
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Supplemental Fig. 4 Supplemental Fig. 4 ctrl Rictor shRNA 1 Rictor shRNA 1 + Rictor WT - + - + - + HRG Rictor p-AKT (T308) p-AKT (S473) pan AKT
30
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Identification_of_mTORC2_as_a_Necessary_Component_of_HRG_ErbB2-Dependent_Cellular_Transformation/22511299/1/files/39973264.pdf
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Sanford et. al. Supplementary Figure S4 Sanford et. al. Supplementary Figure S4 Sanford et. al. Supplementary Figure S4 Sanford et. al. Supplementary Figure S4 A. B. C. A. A. B. C. B. B. C.
34
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Inflammatory_Monocyte_Mobilization_Decreases_Patient_Survival_in_Pancreatic_Cancer_A_Role_for_Targeting_the_CCL2_CCR2_Axis/22452629/1/files/39903704.pdf
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T - Localized cancer M - Metastatic cancer N - Non- Recurrent R - Recurrent
15
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Integrative_Microarray_Analysis_of_Pathways_Dysregulated_in_Metastatic_Prostate_Cancer/22370967/1/files/39816054.pdf
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4 4
2
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_MicroRNA-205_Inhibits_Src-Mediated_Oncogenic_Pathways_in_Renal_Cancer/22389453/1/files/39834969.pdf
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Supplemental Figure 4 Supplemental Figure 4 Supplemental Figure 4
9
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Molecular_Dissection_of_AKT_Activation_in_Lung_Cancer_Cell_Lines/22510201/1/files/39972082.pdf
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Figure S4. Figure S4. Figure S4.
6
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Molecular_Photoacoustic_Imaging_of_Follicular_Thyroid_Carcinoma/22450767/1/files/39901845.pdf
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0 1 2 3 4 5 6 7 BMP4 CHEK2 DNMT3B FN1 HMGA1 HSC20 KITLG PTK2 SHMT1 SYNE2 UTRN Genes Normal Pool 1 Normal Pool 2 Serous Pool 1 Serous Pool 2 0 1 2 3 4 5 6 7 BMP4 CHEK2 DNMT3B FN1 HMGA1 HSC20 KITLG PTK2 SHMT1 SYNE2 UTRN Genes Normal Pool 1 Normal Pool 2 Serous Pool 1 Serous Pool 2
64
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Multiple_Alternative_Splicing_Markers_for_Ovarian_Cancer/22373678/1/files/39818915.pdf
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ACNB1 LOC402592 OSBPL5 LOC389167 SAPS2 HSF1 PAK7 E2 ACNB1 LOC402592 OSBPL5 LOC389167 SAPS2 HSF1 PAK7 E2 CNB1 LOC402592 OSBPL5 LOC389167 SAPS2 HSF1 PAK7
23
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Novel_Estrogen_Receptor-_Binding_Sites_and_Estradiol_Target_Genes_Identified_by_Chromatin_Immunoprecipitation_Cloning_in_Breast_Cancer/22367825/1/files/39812897.pdf
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94
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Paradoxical_Relationship_between_Chromosomal_Instability_and_Survival_Outcome_in_Cancer/22388774/1/files/39834263.pdf
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Figure S4 Figure S4 Figure S4 Figure S4
8
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Resveratrol_Inhibits_Proliferation_and_Survival_of_Epstein_Barr_Virus_Infected_Burkitt_s_Lymphoma_Cells_Depending_on_Viral_Latency_Program/22519137/1/files/39981756.pdf
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FIGURE S4 50 100 150 200 250 (x 1,000) PI-A 0 250 500 750 1,000 1,250 Count Specimen_001-iec-6 J6 50 100 150 200 250 (x 1,000) PI-A 0 250 500 750 1,000 1,250 Count Specimen_001-iec-6 50 100 150 200 250 (x 1,000) PI-A 0 50 100 150 200 250 300 350 400 450 Count Specimen_001-MCF10A J6 50 100 150 200 250 (x 1,000) PI-A 0 50 100 150 200 250 300 350 400 Count Specimen_001-MCF10A ctl 50 100 150 200 250 (x 1,000) PI-A 0 25 50 75 100 125 Count Specimen_001-NIH - b PI 370 50 100 150 200 250 (x 1,000) PI-A 0 50 100 150 Count Specimen_001-NIH - b PI 370rj6 Vector H-RasV12 H-RasV12 Cells >4N (%) Vector H-Ras V12 Cells >4N (%) Vector H-Ras V12 Cells >4N (%) Vector H-Ras V12 0 5 10 15 20 0 5 10 15 20 0 5 10 15 20 *** *** *** IEC-6 MCF-10A Vector Vector NIH 3T3 H-RasV12 FIGURE S4 50 100 150 200 250 (x 1,000) PI-A 0 250 500 750 1,000 1,250 Count Specimen_001-iec-6 J6 50 100 150 200 250 (x 1,000) PI-A 0 250 500 750 1,000 1,250 Count Specimen_001-iec-6 50 100 150 200 250 (x 1,000) PI-A 0 50 100 150 200 250 300 350 400 450 Count Specimen_001-MCF10A J6 50 100 150 200 250 (x 1,000) PI-A 0 50 100 150 200 250 300 350 400 Count Specimen_001-MCF10A ctl 50 100 150 200 250 (x 1,000) PI-A 0 25 50 75 100 125 Count Specimen_001-NIH - b PI 370 50 100 150 200 250 (x 1,000) PI-A 0 50 100 150 Count Specimen_001-NIH - b PI 370rj6 Vector H-RasV12 H-RasV12 Cells >4N (%) Vector H-Ras V12 Cells >4N (%) Vector H-Ras V12 Cells >4N (%) Vector H-Ras V12 0 5 10 15 20 0 5 10 15 20 0 5 10 15 20 *** *** *** IEC-6 MCF-10A Vector Vector NIH 3T3 H-RasV12 FIGURE S4 50 100 150 200 250 (x 1,000) PI-A 0 250 500 750 1,000 1,250 Count Specimen_001-iec-6 J6 50 100 150 200 250 (x 1,000) PI-A 0 250 500 750 1,000 1,250 Count Specimen_001-iec-6 H-RasV12 Cells >4N (%) Vector H-Ras V12 0 5 10 15 20 *** IEC-6 Vector FIGURE S4 FIGURE S4 50 100 150 200 250 (x 1,000) PI-A 0 250 500 750 1,000 1,250 Count Specimen_001-iec-6 J6 50 100 150 200 250 (x 1,000) PI-A 0 250 500 750 1,000 1,250 Count Specimen_001-iec-6 50 100 150 200 250 (x 1,000) PI-A 0 50 100 150 200 250 300 350 400 450 Count Specimen_001-MCF10A J6 50 100 150 200 250 (x 1,000) PI-A 0 50 100 150 200 250 300 350 400 Count Specimen_001-MCF10A ctl 75 100 125 Count Specimen_001-NIH - b PI 370 100 150 Count Specimen_001-NIH - b PI 370rj6 Vector H-RasV12 H-RasV12 Cells >4N (%) Vector H-Ras V12 >4N (%) Cells >4N (%) Vector H-Ras V12 0 5 10 15 20 0 5 10 15 20 10 15 20 *** *** *** IEC-6 MCF-10A Vector Vector H 3T3 H-RasV12 50 100 150 200 250 (x 1,000) PI-A 0 250 500 750 1,000 1,250 Count Specimen_001-iec-6 IEC-6 Vector 50 100 150 200 250 (x 1,000) PI-A 0 250 500 750 Count 50 100 150 200 250 (x 1,000) PI-A 0 250 500 750 Count 50 100 150 200 250 (x 1,000) PI-A 0 50 100 150 200 250 300 350 400 450 Count Specimen_001-MCF10A J6 50 100 150 200 250 (x 1,000) PI-A 0 50 100 150 200 250 300 350 400 Count Specimen_001-MCF10A ctl Vector H-RasV12 Cells >4N Vector H-Ras V12 Cells >4N (%) Vector H-Ras V12 0 5 10 0 5 10 15 20 *** IEC-6 MCF-10A 50 100 150 200 250 (x 1,000) PI-A 0 250 50 100 150 200 250 (x 1,000) PI-A 0 250 50 100 150 200 250 (x 1,000) PI-A 0 50 100 150 200 250 300 350 400 450 Count Specimen_001-MCF10A J6 50 100 150 200 250 (x 1,000) PI-A 0 50 100 150 200 250 300 350 400 Count Specimen_001-MCF10A ctl 50 100 150 200 250 (x 1,000) PI-A 0 25 50 75 100 125 Count Specimen_001-NIH - b PI 370 50 100 150 200 250 (x 1,000) PI-A 0 50 100 150 Count Specimen_001-NIH - b PI 370rj6 Vector H-RasV12 C Vector H-Ras V12 Cells >4N (%) Vector H-Ras V12 Cells >4N (%) Vector H-Ras V12 0 5 0 5 10 15 20 0 5 10 15 20 *** *** MCF-10A Vector NIH 3T3 H-RasV12 (x 1,000) PI-A (x 1,000) PI-A 50 100 150 200 250 (x 1,000) PI-A 0 50 100 150 200 250 300 350 400 450 Count Specimen_001-MCF10A J6 50 100 150 200 250 (x 1,000) PI-A 0 50 100 150 200 250 300 350 400 Count Specimen_001-MCF10A ctl Vector H-RasV12 Vector H-Ras Cells >4N (%) Vector H-Ras V12 0 5 10 15 20 *** MCF-10A 50 100 150 200 250 (x 1,000) PI-A 0 50 100 150 200 250 300 350 400 450 Count Specimen_001-MCF10A J6 H-RasV12 50 100 150 200 250 (x 1,000) PI-A 0 50 100 150 200 250 300 350 400 Count Specimen_001-MCF10A ctl Vector MCF-10A 50 100 150 200 250 (x 1,000) PI-A 0 25 50 75 100 125 Count Specimen_001-NIH - b PI 370 50 100 150 200 250 (x 1,000) PI-A 0 50 100 150 Count Specimen_001-NIH - b PI 370rj6 Cells >4N (%) Vector H-Ras V12 0 5 10 15 20 *** Vector NIH 3T3 H-RasV12 50 100 150 200 250 (x 1,000) PI-A 0 25 50 75 100 125 Count Specimen_001-NIH - b PI 370 Vector NIH 3T3 Count
936
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Sef_Downregulation_by_Ras_Causes_MEK1_2_to_Become_Aberrantly_Nuclear_Localized_Leading_to_Polyploidy_and_Neoplastic_Transformation/22395299/1/files/39840926.pdf
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** . 4 A B C ** . 4 A B C ** A B C ** A A A B C B C
24
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_The_Activation_of_MEK_ERK_Signaling_Pathway_by_Bone_Morphogenetic_Protein_4_to_Increase_Hepatocellular_Carcinoma_Cell_Proliferation_and_Migration/22516785/1/files/39979359.pdf
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NMTS NMTS
2
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_The_Effects_of_Chemotherapy_on_Cognitive_Function_in_a_Mouse_Model_A_Prospective_Study/22446000/1/files/39897045.pdf
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CD8+ ICOS+ Wit 0.6% Wit
5
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_The_ICOS_ICOSL_Pathway_Is_Required_for_Optimal_Antitumor_Responses_Mediated_by_Anti_CTLA-4_Therapy/22388822/1/files/39834311.pdf
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Supplemental Figure S4 Supplemental Figure S4
6
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Threonine_2609_Phosphorylation_of_the_DNA-Dependent_Protein_Kinase_Is_a_Critical_Prerequisite_for_Epidermal_Growth_Factor_Receptor_Mediated_Radiation_Resistance/22516555/1/files/39979123.pdf
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VISTA Ig 3.1 4.13 VISTA-Ig ber 60 cell numb (x10^3) 20 40 101 102 103 104 0.11 .69 control 0 STA Ig 4.13 STA-Ig ber 60 cell numb (x10^3) 20 40 01 102 103 104 0.11 contro 0 VIST VIST
40
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_VISTA_Regulates_the_Development_of_Protective_Antitumor_Immunity/22401461/1/files/39847253.pdf
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4 8 12 Met Incorporation (x 104 cpm) LMS 4 8 12 Met Incorporation (x 104 cpm) LMS 8 12 orporation cpm) LMS orporation
24
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_c-Myc_and_eIF4F_Are_Components_of_a_Feedforward_Loop_that_Links_Transcription_and_Translation/22374606/1/files/39819846.pdf
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7 8 evels B ** 3 4 5 6 ive BCL2L11 le 0 1 2 Relati 7 8 vels D ** 3 4 5 6 tive PMAIP1 lev 0 1 2 Relat 7 8 evels B ** 3 4 5 6 ive BCL2L11 le 0 1 2 Relati 7 8 vels D ** 3 4 5 6 tive PMAIP1 lev 0 1 2 Relat **
65
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_c-Src_Modulates_Estrogen-Induced_Stress_and_Apoptosis_in_Estrogen-Deprived_Breast_Cancer_Cells/22397577/1/files/39843273.pdf
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Figure S4 B D F Figure S4 B D F Figure S4 D F D F
16
https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_miR-31_Is_a_Broad_Regulator_of_1-Integrin_Expression_and_Function_in_Cancer_Cells/22519222/1/files/39981841.pdf
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Figure S5 Figure S5 A. Fig A. B. Fi A. B. B.
12
https://figshare.com/articles/journal_contribution/Supplementary_Figure_5_from_Activation_of_the_Wnt_Pathway_through_AR79_a_GSK3_Inhibitor_Promotes_Prostate_Cancer_Growth_in_Soft_Tissue_and_Bone/22509189/1/files/39971064.pdf
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4
https://figshare.com/articles/journal_contribution/Supplementary_Figure_5_from_Alternative_Cleavage_and_Polyadenylation_during_Colorectal_Cancer_Development/22452581/1/files/39903656.pdf
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