This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cardiovascular system, Subject name: Pharmacology
[{'content': 'Lipid lowering drug that significantly reduces lipo protein-a levels is? \nSelect and explain. \nA. Fenofibrate, B. Gemfibrosil, C. Rosuvastatin, D. Nicotinic acid', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Nicotinic acid is B3 vitamin which in higher doses reduce plasma lipids. When nicotinic acid is given, TGs and VLDL decrease rapidly, followed by a moderate fall in LDH-CH and total CH. It also reduces Lp(a) which is considered more atherogenic. It acts by inhibiting lipoprotein lipase produced from the endothelium From essentials of medical pharmacology K D Tripathi 7th edition page no 640', 'role': 'assistant'}]