This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti Microbial, Subject name: Pharmacology
[{'content': 'Mechanism of action tacrolimus is - \nSelect and explain. \nA. Inhibition of calcineurin, B. Antimetabolite, C. mTOR inhibitor, D. Inhibition of DNA synthesis', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Inhibition of calcineurin Tacrolimuso It is a macrolide immunosuppressant agent.o Its mechanism of action is similar to cyclosporine, i.e. inhibition of transcription of IL-2 and T-cell proliferation, but it binds to other immunophiiin called FKBP (in contrast to cyclosporine which binds to cyclophilin). Subsequent steps are some, i.e. inhibition of calcineurin, which inhibits T cell activation,o Tocrolimus is 10-100 times more potent than cyclosporine,o It is also more toxic than cyclosporin.o Adverse effects are nephrotoxicity (most common), neurotoxicity, hyperglycemia (DM).Mechanism of nephrotoxicity - Perigiomerular afferent arteriolar vasoconstrication and reduced GFR.", 'role': 'assistant'}]