This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.V.S., Subject name: Pediatrics
[{'content': 'Indomethacin causes: \nSelect and explain. \nA. Closure of ductus in premature neonate, B. Patent ductus arteriosus, C. Closure of ductus in term & premature neonates, D. Closure of ductus in older children also', 'role': 'user'}, {'content': "Answer: A \nExplanation: a. Closure of ductus in premature neonate(Ref: Nelson's 20/e p 2197)Indomethacin, a Prostaglandin inhibitor is used in medical closure of Ductus arteriosus in preterm neonates with PDA.", 'role': 'assistant'}]