This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Pathology
[{'content': 'Which of the following is the most significant factor for development of gastric carcinoma? \nSelect and explain. \nA. paneth cell metaplasia, B. Pyloric metaplasia, C. Intestinal metaplasia, D. Ciliated metaplasia', 'role': 'user'}, {'content': 'Answer: C \nExplanation: There are some conditions of pre-malignant changes in the gastric mucosa which have increased risk to the development of gastric cancer: I) hypo- or achlorhydria in atrophic gastritis of gastric mucosa with intestinal metaplasia. ii)Adenomatous (neoplastic) polyps of the stomach. iii)Chronic gastric ulcer (ulcer-cancer), and its association with achlorhydria. iv) Stump carcinoma in patients who have undergone paial gastrectomy. TEXTBOOK OF PATHOLOGY 6TH EDITION HARSH MOHAN PAGE NO:555', 'role': 'assistant'}]