This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: JIPMER 2017, Subject name: Pathology
[{'content': 'Schistocytes in peripheral smear are seen in all except: \nSelect and explain. \nA. DIC, B. Sickle cell anemia, C. TTP, D. HUS', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Schistocyte is fragmented RBC which is seen in any condition where there is micro and macro angiopathic hemolytic anemias. Microangiopathic hemolytic anemia is most commonly seen with DIC, TTP, hemolytic-uremic syndrome (HUS), malignant HTN, SLE, and disseminated cancer. Macroangiopathic schistocyte is seen in patient with prosthetic hea valve. Sickle cell anemia: Blockage of vessels by sickled cells causes pain crises and tissue infarction, paicularly of the marrow and spleen. Red cell membrane damage caused by repeated bouts of sickling results in a moderate to severe hemolytic anemia.', 'role': 'assistant'}]