This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
[{'content': 'Which of the following antimicrobial is effective against on organism producing extended spectrum beta lactamase? \nSelect and explain. \nA. Amoxicillin- Clavulinic acid, B. Cefepime, C. Piperacillin-Tazobactam, D. Ceftriaxone', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Tazobactam is a Beta-lactamase inhibitor similar to sulbactam. Its pharmacokinetics matches with piperacillin with which it has been combined for use in severe infections like peritonitis, pelvic/ urinary /respiratory infections caused by Beta-lactamase producing bacilli . However, the combination is not active against piperacillin-resistant Pseudomonas, because tazobactam (like clavulanic acid and sulbactam) does not inhibit inducible chromosomal Beta lactamase produced by Enterobacteriaceae. It is also of no help against Pseudomonas that develop resistance by losing permeability to piperacillin. ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SIXTH EDITION PAGE NO:703', 'role': 'assistant'}]