This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'True about pendred syndrome - \nSelect and explain. \nA. Diffuse colloid goiter, B. Nodular goiter, C. Mental retardation, D. All', 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans. is 'a' i.e., Diffuse colloid goiter; 'b' i.e., Nodular goiter; 'c' i.e., Mental retardation Pendred syndrome o It is an autosomal recessive disorder o Goiter with sensory neural deafness is seen in pendred syndrome. o Goiter is due to several mutation in TPO gene which lead to defective organification and congenital hypothyroidism. o Hearing loss is usually present at bih but goiter appears after pubey. o Goitre is usually soft and diffuse and later life become nodular. o It is due to defect in a sulfate transpoer protein common to thyroid gland and cochlea.", 'role': 'assistant'}]