This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General Pharmacology, Subject name: Pharmacology
[{'content': 'Phase I trial is done to test: \nSelect and explain. \nA. Safety, B. Efficacy, C. Dose, D. Pharmacokinetics', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ans. D. PharmacokineticsPhase I trial is also called First in human trial. In this phase, 10-100 healthy people are enrolled to calculate pharmacokinetic data. Phase 0 trials are also done sometimes prior to phase I studies to calculate early pharmacokinetic data. Phase II and III trials usually enrol patients. Phase II trials enrol 50-100 and usually determine drug efficacy and dose ranging. Phase III trials confirm the efficacy in larger population (100-1000). Phase IV trials are also known as postmarketing studies which determine safety (adverse drug reactions, adverse events, and drug-drug interactions). Even safety of long-term drug treatment can be determined in Phase IV trials which can be missed in clinical trials due to limited duration of clinical trials.', 'role': 'assistant'}]