This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Urology, Subject name: Surgery
[{'content': 'True about PSA is all except \nSelect and explain. \nA. Levels increase in BPH, B. Levels increase with age, C. Finasteride increases PSA level, D. Metastatic prostate cancer increase PSA level', 'role': 'user'}, {'content': "Answer: C \nExplanation: Prostate-specific antigen (PSA) is a glycoprotein that is a serine protease.Its function may be to facilitate liquefaction of semen, but it is a marker for prostatic disease.The levels increase with age, with prostate cancer and with BPH. There are age-related values but, in general, in men aged 50-69 years, a level of about 3-4 ng/mL would prompt a discussion about the need for prostate biopsy Its level in men with metastatic prostate cancer is usually increased to >30 ng/mL and falls to low levels after successful androgen ablation. Men with locally confined prostate cancer usually have serum PSA levels <10-15 ng/mL.Finasteride and dutasteride, which are used to treatBPH--lower a man's PSA levelPSA is a useful tumour marker in the postsurgery setting, where a supersensitive assay, with sensitivity to 0.02 ng/mL, facilitates early detection of biochemical recurrence.Bailey and Love 27e pg: 1457", 'role': 'assistant'}]