This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Misc. (R.B.C), Subject name: Pathology
[{'content': 'Person having heterozygous sickle cell trait is protected from infection of - \nSelect and explain. \nA. Plasmodium falciparum, B. P.vivax, C. Pneumococcus, D. Salmonella', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. (a) Plasmodium falciparum(Ref: Robbins 9th/pg 635-636; 8th/pg 645-646; Wintrobe's 12th/pg 1038)Person having heterozygous sickle cell trait is protected from infection of Plasmodium falciparum Mechanism by which patients with sickle cell trait are protected against Malaria:Preferential sickling of parasitized cells has been seen in the blood of children with sickle cell trait & malaria.Selective removal of sickled cells from the circulation probably reduces the degree of parasitemia and substantially limits the infectious process.", 'role': 'assistant'}]