This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Medicine
[{'content': 'Osteoporosis is caused by all except - \nSelect and explain. \nA. Methotrexate, B. Glucocoicoids, C. Heparin, D. Estradiol', 'role': 'user'}, {'content': "Answer: D \nExplanation: Medications causing osteoporosis are : * Aluminum (in antacids) * Anticoagulants (heparin) * Anticonvulsants * Aromatase inhibitors * Barbiturates * Cancer chemotherapeutic drugs * Cyclosporine A and tacrolimus * Depo-medroxyprogesterone (premenopausal contraception) * Glucocoicoids (>=5 mg/d prednisone or equivalent for >=3 months) * Gonadotropin-releasing hormone antagonists and agonists * Lithium * Methotrexate * Proton pump inhibitors * Selective serotonin reuptake inhibitors * Tamoxifen (premenopausal use) * Thiazolidinediones (such as pioglitazone and rosiglitazone) * Thyroid hormones (in excess) * Parenteral nutrition Reference : page 2490 Harrison's Principles of Internal Medicine 19th edition", 'role': 'assistant'}]