This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'The type of mammary ductal carcinoma in situ (DCIS) most likely to result in a palpable abnormality in the breast is - \nSelect and explain. \nA. Apocrine DCIS, B. Neuroendocrine DCIS, C. Well differentiated DCIS, D. Comedo DCIS', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Carcinoma of the breast is divided into :\n\nCarcinoma in situ → neoplastic cells is limited to ducts and lobules by the basement membrane.\nInvasive carcinoma (infiltrating carcinoma) → cells invade beyond the basement membrane.\n\nCaricnoma in situ :\n\nIt is of two types\n\nA. Ductal carcinoma insitu (DCIS, intraductal carinoma )\n\nMost frequently present as manzmographic calcification.\nRarely palpable mass may also occur in comedocarcinoma.\nDCTS is of two types -\n\ni.\xa0Comedocarcinoma\nii.\xa0Noncomedo DCTS →\xa0Solid, cribriform, papillary or micropapillary\n\nB. Lubular carcinoma in Situ (LCIS)\n\nAlways an incidental finding in a biopsy performed for another reason.\nLCIS is not associated with calcification → Therefore, it remains infrequent with or without mammography (in contrast to DCIS)\nFrequently multicentric and bilateral\nSignet ring cells are common.', 'role': 'assistant'}]