This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Ophthalmology
[{'content': 'Earliest change in diabetic retinopathy is \nSelect and explain. \nA. Hyaloid change, B. Hard exudate, C. Microaneurysms and pin point haemorrhages, D. Vitreous haemorrhage', 'role': 'user'}, {'content': 'Answer: C \nExplanation: (C) Microaneurysms and pin point haemorrhages # Non-proliferative diabetic retinopathy (NPDR)> Ophthalmoscopic features of NPDR include: Microaneurysms in the macular area*(the earliest detectable lesion). Retinal haemorrhages both deep (dot and blot haemorrhages) and superficial haemorrhages (flame-shaped). Hard exudates -yellowish-white waxy-looking patches are arranged in clumps or in circinate pattern. These are commonly seen in the macular area. Retinal oedema characterised by retinal thickening. Cotton-wool spots (if>8, there is high risk of developing PDR). Venous abnormalities, beading, looping and dilatation. Intraretinal microvascular abnormalities (IRMA). Dark-blot haemorrhages representing haemorrhagic retinal infarcts.', 'role': 'assistant'}]