This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Biochemistry
[{'content': 'Which one of the following diseases or conditions predisposes a patient to acetaminophen toxicity? \nSelect and explain. \nA. Type 1 diabetes, B. Type 2 diabetes, C. Alcoholism, D. Pernicious anemia', 'role': 'user'}, {'content': 'Answer: C \nExplanation: The enzyme that produces the toxic NAPQI, CYP2E1, is induced by alcohol. Diabetes (either type 1 or type 2) will not lead to an induction of CYP2E1, nor will pernicious anemia (intrinsic factor deficiency) or obesity (in the absence of alcoholism). Chronic alcoholics have a reduced tolerance for acetaminophen because of the induction of the MEOS, which results in increased levels of CYPE21.', 'role': 'assistant'}]