This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of nucleic acids, Subject name: Biochemistry
[{'content': 'Lesch - Nyhan Syndrome - associated with \nSelect and explain. \nA. Purine necleoside phosphorylase deficiency, B. Adenosine deaminase deficiency, C. Hypoxanthine - guanine phosphoribosyl transferase defect, D. Xanthine oxidase deficiency', 'role': 'user'}, {'content': 'Answer: C \nExplanation: It is X-linked inherited disorder of purine metabolismDeficiency of HGPase, so the rate of salvage pathway is decreased resulting in the accumulation of PRPP and decreased level of inhibitory purine nucleotide Disease is characterized by self-mutilation, mental retardation excessive uric acid and nephrolithiasis Ref: DM Vasudevan, 7th edition, page no: 568', 'role': 'assistant'}]