This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immune system, Subject name: Medicine
[{'content': "Macrophage activation syndrome IS seen in association with? \nSelect and explain. \nA. Systemic sclerosis, B. Sweet's syndrome, C. Polyaeritis nodosa, D. SLE", 'role': 'user'}, {'content': 'Answer: D \nExplanation: Macrophage activation syndrome (MAS) is a life-threatening complication of rheumatic disease that, for unknown reasons, occurs much more frequently in individuals with systemic juvenile idiopathic ahritis (SJIA) and in those with adult-onset Still disease. Macrophage activation syndrome is characterized by pancytopenia, liver insufficiency, coagulopathy, and neurologic symptoms and is thought to be caused by the activation and uncontrolled proliferation of T lymphocytes and well-differentiated macrophages, leading to widespread hemophagocytosis and cytokine overproduction . Ref - reseaechgate.net', 'role': 'assistant'}]