This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Medicine
[{'content': 'Non pitting edema is seen in ? \nSelect and explain. \nA. Congestive cardiac failure, B. Myxedema, C. Liver failure, D. Renal failure', 'role': 'user'}, {'content': "Answer: B \nExplanation: A consequence of prolonged hypothyroidism is increased dermal infiltration of glycosaminoglycans (mucopolysaccharides, hyaluronic acid and chondroitin sulphate) which traps water, giving rise to skin thickening without pitting (myxedema). Typical features include a puffy face with edematous eyelids and nonpitting pretibial edema. Reference : page 2291 Harrison's Principles of Internal Medicine 19th edition and page 743 Davidson's Principles and practice of Medicine 22nd edition", 'role': 'assistant'}]