This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autacoids, Subject name: Pharmacology
[{'content': 'Which is not a 2nd generation anti-histamine agents \nSelect and explain. \nA. Cetirizine, B. Cyclizine, C. Loratidine, D. Fexofenadine', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Anti histamines are classified into first generation and second generation compounds on the basis of CNS penetration and anti cholinergic propeies. First generation anti-histamine can penetrate blood brain barrier and possess additional anti cholinergic propeies which are lacking in second generation drugs. Cyclizine is a first generation where as cetrizine, loratidine and fexofenadine are second generation drugs Refer Goodman & Gilman 12/e p921', 'role': 'assistant'}]