This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': "Prophylactic gonadectomy is done in \nSelect and explain. \nA. Testicular feminising syndrome, B. Klinefelter's syndrome, C. Kalman's syndrome, D. Down's syndrome", 'role': 'user'}, {'content': 'Answer: A \nExplanation: Gonadectomy is often advised in CAIS due to the risk of gonadal malignancy.\nThe malignancy risk is poorly defined (possibly 5-10% in childhood rising to 30% by the age of 50 years) and is thought to be due to intra abdominal position of the testes.\n\nTiming of gonadectomy is controversial.\n\nSome clinicians advocate early i.e. childhood gonadectomy due to the malignant potential with subsequent HRT to induce puberty.\nOthers prefer to delay gonadectomy until after puberty to allow endogenous gonadal hormones to work throughout puberty.\nHormone replacement therapy is essential after gonadectomy for many aspects of health and well being. One of these is the maintenance of bone mineral density.\n\nMore on management of CAIS\n\nMajority of women with CAIS will have a shortened vagina.\nThe hypoplastic vagina requires treatment.\nThe two main options for vaginal enlargement are vaginoplasty surgery or manual vaginal dilatation.\nVaginal dilatation is usually the first line treatment.', 'role': 'assistant'}]