This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Liver & Biliary Tract, Subject name: Pathology
[{'content': 'Focal or confluent periportal necrosis along with ballooning degeneration of hepatocytes with or without Mallory bodies and megamitochondriais suggestive of? \nSelect and explain. \nA. Acute Hepatitis B, B. Chronic Hepatitis B, C. Alcoholic liver injury, D. Primary HCC', 'role': 'user'}, {'content': "Answer: C \nExplanation: Ans. (c) Alcoholic liver injury(Ref: Rosai and Ackerman's Surgical Pathology, Volume 1, chapter 13, Box 13.2)Megamitochondria appear as eosinophilic, PAS- diastase-negative, round, oval, or cigar-shaped inclusionsBetter visualized with chromotrope-aniline blue (CAB) stain & immunohistochemistry.They are not specific for alcohol-induced liver disease, but found more frequently in alcohol-related fibrosisOxyphilic granular hepatocytes or oncocytes are a common, though not pathognomonic, cellular component in acute and chronic alcoholic liver disease.On Electron microscopy, Oncocytes are characterized by a large number of mitochondria (mitochondriosis).", 'role': 'assistant'}]