This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
[{'content': 'Gastric carcinoma is associated with all EXCEPT: \nSelect and explain. \nA. Inactivation of p53, B. Over expression of C -erb, C. Over expression of C-met, D. Activation of RAS', 'role': 'user'}, {'content': 'Answer: B \nExplanation: ANSWER: (B) Overexpression of C-erbREF: Robbins 7thedition page 824, The diversity of gastric carcinoma: pathogenesis, diagnosis, and therapy by Michio Kaminishi, Kaiyo Takubo, Ken-ichi Mafune Page 55MOLECULAR STOMACH CARCINOGENESIS:p53 mutation commonly participates in early steps of stomach carcinogenesis.Amplification and overexpression of c-met and cyclin E genes are frequently associated with advanced stagesReduced expression of p27 participates in both the development and progression of gastric carcinoma.K-ras mutation, HER-2/c-erb/B2 amplification, and APC mutation preferentially occur in well-differentiated type.Inactivation of cadherin and catenins and amplification of K-sam and c-met are frequently associated with poorly differentiated with or scirrhous type carcinoma.', 'role': 'assistant'}]