This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hemolytic anemia, Subject name: Pediatrics
[{'content': 'Beta globin missense gene mutation seen in? \nSelect and explain. \nA. Thalassemia, B. Sickle cell anemia, C. Hb Ba, D. HbH', 'role': 'user'}, {'content': 'Answer: B \nExplanation: - Point mutation (missense) in 6th codon of b-globin gene leading to replacement of glutamic acid by valine residue is seen in sickle cell anemia OTHER OPTIONS: - Common mutations of Beta Thalassemia in India: IVS 1-5 G - C IVS 1-1 G - T Codon 41/42 Codon 819 619 bp deletion - Hb Ba: Most severe form of alpha thalassemia, results from the loss of all four alpha-globin alleles. - HbH: D/t loss of three of four alpha-globin alleles.', 'role': 'assistant'}]