This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Dental
[{'content': 'A 12 year old female patient complains of multiple missing teeth. The karyogram of  the patient is shown below. Intra-oral ﬁndings include missing 12, 17, 33 and 43.\nOpen bite, macroglossia and generalised periodontitis is also present. Which of the  following is commonly seen in this condition? \nSelect and explain. \nA. Mouth breathing, B. Prognathic maxilla, C. Macrodontia, D. High level of caries', 'role': 'user'}, {'content': "Answer: A \nExplanation: Patient is suffering from Down's syndrome (trisomy of chromosome No. 21).\nSkeletal ﬁndings are an underdeveloped mid-face, creating a prognathic occlusal relationship.\xa0\nOral\xa0ﬁndings include mouth breathing, open bite, appearance of macroglossia, ﬁssured lips and tongue,\xa0angular cheilitis, delayed eruption times, missing and malformed teeth, oligodontia, small roots,\xa0microdontia, crowding, and a low level of caries.\xa0\nChildren with Down syndrome experience a high\xa0incidence of rapid, destructive periodontal disease, which may be related to local factors such as tooth\xa0morphology, bruxism, malocclusion, and poor oral hygiene.", 'role': 'assistant'}]