This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
[{'content': 'Epitope spreading refers to \nSelect and explain. \nA. A type of mechanism of spread of malignant tumor, B. One type of mechanism of HIV dissemination, C. A mechanism for the persistence and evolution of autoimmune disease, D. One of the mechanism of apoptosis', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ref Robbins 9/e p217 It is a phenomenon in which an immune response against one self antigens causes tissues damage releasing other antigens .and resulting in the activation of lymphocytes by these newly encountered epitope', 'role': 'assistant'}]