This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Genetics And Genetic Disorders, Subject name: Pediatrics
[{'content': 'Submicroscopic deletions of any size can be detected by: \nSelect and explain. \nA. Multiplex ligation-Dependent probe amplification (MLPA), B. Southern blotting, C. Cytogenomic array technology, D. Chromosome painting', 'role': 'user'}, {'content': "Answer: A \nExplanation: a. Multiplex ligation-Dependent probe amplification(Ref: Nelson's 20/e p 605, Ghai 8/e p 6045)Multiplex Ligation-Dependent Probe Amplification (MLPA): It is a technique which mixes DNA hybridization, ligation, & PCR amplification to detect deletions & duplications of any size, including anomalies that are too large to be detected by PCR and too small to be identified by FISH.", 'role': 'assistant'}]