This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'All of the following statements about immunosuppressants are true EXCEPT : \nSelect and explain. \nA. Sirolimus acts by inhibiting the action of IL–2, B. Tacrolimus inhibits calcineurin pathway, C. Mycophenolate acts by inhibiting GMP dehydrogenase, D. Cyclosporine is an integeral component of transplant rejection regimen', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Mycophenolate mofetil acts by blocking IMP dehydrogenase.\nCyclosporine and tacrolimus are calcineurin inhibitors that act by decreasing the transcription of IL-2 gene. Cyclo\xadsporine is commonly used to prevent rejection in transplant recipients.\nSirolimus acts by inhibiting mTOR (a tyrosine kinase) that is the target of IL-2.', 'role': 'assistant'}]