This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: COPD and Asthma, Subject name: Medicine
[{'content': 'Roflumilast is introduced in management of COPD in? \nSelect and explain. \nA. Group A, B. Group B, C. Group C, D. Group D', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Group A Low Risk, low symptom Bronchodilator Group B Low Risk, High symptom LABA/LAMA, if failed- LAMA+LABA Group C High Risk, Low symptom LAMA+LABA or LABA+ICS Group D High Risk, High symptom LAMA+LABA+ICS | symptoms persists Phosphodiesterase inhibitor (Roflumilast) or Macrolides', 'role': 'assistant'}]