This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
[{'content': 'With Intracytoplasmic sperm injection, which of the following step in fertilization is skipped? \nSelect and explain. \nA. Sperm-oocyte binding, B. Zona reaction, C. Acrosome reaction, D. Cortical reaction', 'role': 'user'}, {'content': 'Answer: C \nExplanation: With ICSI method, acrosome reaction is skipped.', 'role': 'assistant'}]