This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Medicine
[{'content': "Lewis body is characteristically is seen in \nSelect and explain. \nA. Parkinsonism, B. Pick's disease, C. Azlheimer's disease, D. Neiman Pick disease", 'role': 'user'}, {'content': 'Answer: A \nExplanation: (A) Parkinsonism # Parkinsonism: Pathologically, it is characterized by development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain. These inclusions have similar structural features to "classical" Lewy Bodies seen subcortically in Parkinson\'s disease> LB\'s have a high concentration of a- synuclein and are pathologic hallmark of parkinson\'s disease# Dementia with Lewy Bodies (DLB) exhibits clinical overlap between Alzheimer\'s disease and Parkinson\'s disease> Additionally, there is a loss of dopamine-producing neurons (in the substantia nigra) similar to that seen in Parkinson\'s disease, and a loss of acetylcholine-producing neurons (in the basal nucleus of Meynert and elsewhere) similar to that seen in Alzheimer\'s disease.> Cerebral atrophy (or shrinkage) also occurs as the cerebral cortex degenerates. Autopsy series have revealed that the pathology of DLB is often concomitant with the pathology of Alzheimer\'s disease.> That is, when Lewy Body inclusions are found in the cortex, they often co-occur with Alzheimer\'s disease pathology found primarily in the hippocampus, including: neurofibrillary tangles (abnormally phosphorylated tau protein), senile plaques (deposited beta-amyloid protein), and granulovacuolar degeneration.', 'role': 'assistant'}]