This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Magnetic Resonance Imaging, Subject name: Radiology
[{'content': 'Tigroid Pattern on MRI is associated with which of the following disease? \nSelect and explain. \nA. Krabbe disease, B. Niemann Pick disease, C. Alexander disease, D. Metachromatic Leukodystrophy', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Metachromatic Leukodystrophy: Is a deep white matter leukodystrophy with sparing of subcoical U-fibers and lamellated or Tigroid pattern of the involved white matter. It is associated with Aryl Sulfatase deficiency. Characterized by bilateral symmetrical confluent areas of periventricular deep white matter signal change, in paicular around the atria and frontal horns with sparing of subcoical U fibres can also leads to a "butterfly pattern". Progression can lead to coical and subcoical atrophy.', 'role': 'assistant'}]