This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Neoplasia, Subject name: Pathology
[{'content': 'Which is not a feature of neoplastic cell? \nSelect and explain. \nA. Hyperchromasia, B. Pleomorphism, C. Atypical mitoses, D. Nuclear cytoplasmic ratio 1:4', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ans: d (Nuclear cytoplasmic ratio 1:4)The hallmark of malignant transformation is anaplasia.The morphological changes in anaplasia are:-1) Pleomorphism: by both cell & nuclei2) Abnormal nuclear morphology: HyperchromasiaNuclear cytoplasmic ratio approaches 1:1 (normal is 1:4 or 1:6)Large nucleoli3) Large no of mitoses4) Loss of polarity5) Other changes: tumour giant cells', 'role': 'assistant'}]