This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
[{'content': 'Drug with high plasma protein binding have \nSelect and explain. \nA. Sho duration of action, B. Less drug interaction, C. Lower volume of distribution, D. All of the above', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ref-KDT 6/e p22 Plasma protein binding causes restriction of drugs in the vascular compament and thus lower volume of distribution. Longer duration of action - as the protein-bound fraction is not available for metabolism ofexcretion. Plasma protein bound drugs tend to have more drug internactions due to displacement of a drug with lower affnity by a drug ywith higher affinity for plasma proteins. Hypoalbuminemia can lead to high concentration of free drug and thus drug toxity.', 'role': 'assistant'}]