This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Which one of the following drugs does not have active metabolite ? \nSelect and explain. \nA. Diazepam, B. Propranolol, C. Allopurinol, D. Lisinopril', 'role': 'user'}, {'content': 'Answer: D \nExplanation: - Among the given options, only Lisinopril does not have an active metabolite. Except for Captopril and Lisinopril, all Angiotensin Converting Enzyme (ACE) inhibitors are prodrugs.\n- Diazepam produces Oxazepam and many other active metabolites.\n- Propranolol can give rise to 4-hydroxyPropranolol which has β antagonist activity\n- Oxypurinol is produced from Allopurinol.', 'role': 'assistant'}]