This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Thyroid Gland, Subject name: Surgery
[{'content': 'The screening test for neonatal hypothyroidism \nSelect and explain. \nA. Blood iodine levels, B. Radioiodine uptake, C. TSH and T4 assays on heel prick blood sample, D. USG', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ans. (c) TSH and T4 assaysRef Harrison 17th edition Chapter 335* Neonatal hypothyroidism is due to thyroid gland dysgenesis in 80-85%, to inborn errors of thyroid hormone synthesis in 10-15%, and is TSH-R antibody-mediated in 5% of affected newborns.* Because of the severe neurologic consequences of untreated congenital hypothyroidism, neonatal screening programs have been established.* These are generally based on measurement of TSH or T4 levels in heel-prick blood specimens* When the diagnosis is confirmed, T4 is instituted at a dose of 10-15g/Kgper day, and the dose is adjusted by close monitoring of TSH levels.* T4 requirements are relatively great during the first year of life, and a high circulating T4 level is usually needed to normalize TSH.* Early treatment with T4 results in normal IQ levels, but subtle neurodevelopmental abnormalities may occur in those with the most severe hypothyroidism at diagnosis or when treatment is suboptimal', 'role': 'assistant'}]