This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
[{'content': "Which of the following is the characteristic pathological feature of Parkinson's disease? \nSelect and explain. \nA. Lewy bodies, B. Babes nodule, C. Neurofibrillary tangle, D. Negri bodies", 'role': 'user'}, {'content': "Answer: A \nExplanation: Lewy bodies are inclusion bodies found within neurons in parkinson' s disease. Bodies are single or multiple, intracy- toplasmic, eosinophilic, round and elongated inclusions that often have a dense core surrounded by a pale halo. Ultrastructurally: These are composed of fine filaments densely packed in the core but loose at the rim. They are composed of a - synuclien, neurofilament antigens, parkin, and ubiquitin. Pathologic examination in parkinson's shows the following: Gross / macroscopically: pallor of the substantia nigra and locus coeruleus Microscopic examination: Loss of catecholaminergic neurons in these regions + gliosis Lewy bodies.", 'role': 'assistant'}]