This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General Pharmacology, Subject name: Pharmacology
[{'content': 'True statement about first order kinetics is \nSelect and explain. \nA. A constant amount of a drug is eliminated in unit time, B. The half-life increases with an increase in dose, C. The rate of elimination is constant, D. The rate of elimination is proportional to the plasma concentration', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ans. (D) The rate of elimination is proportional to the plasma concentration (Ref: KDT 8th/e p38)Drugs may follow zero order or first order kinetics. It depends on the following formula:Rate of Elimination a {PlasmaConcentration}order* Thus, if a drug follows zero order kinetics, {PlasmaConcentration}0 is equal to one, in other words rate of elimination is independent of plasma concentration or rate of elimination is constant.* From the above formula, rate of elimination is proportional to plasma concentration for the drugs following first order kinetics.', 'role': 'assistant'}]