This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Howell-jolly bodies are seen in: September 2005 \nSelect and explain. \nA. Sickle cell anemia, B. Splenectomy, C. Both of the above, D. None of the above', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ans. C: Both of the above Howell-Jolly bodies are histopathological findings of basophilic nuclear remnants (clusters of DNA) in circulating erythrocytes. During maturation in the bone marrow erythrocytes normally expel their nuclei, but in some cases a small poion of DNA remains Howell-Jolly bodies are present in some red cells due to asplenia. Common causes of asplenia are splenectomy due to trauma and autosplenectomy caused by sickle cell anemia.', 'role': 'assistant'}]