This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Anatomy
[{'content': 'Screening method for medullary carcinoma thyroid is \nSelect and explain. \nA. S. alkaline phosphate, B. S. calcium, C. Serum calcitonin, D. S. acid phosphatase', 'role': 'user'}, {'content': 'Answer: C \nExplanation: MCT can be of two types - sporadic and familial (occurring in MEN syn. 2A & 2B and Familial cases without MEN syn.) The familial MTC are more aggressive, multicentric (bilateral) and present at a younger age, therefore high risk cases should be screened for MTC by - detecting RET mutation. The genetic screening tests are supplemented by estimating serum calcitonin levels in the basal state and after stimulation by either calcium or pentagastrin. Prophylactic total thyroidectomy is indicated in RET mutation carriers once the mutation is confirmed. Ref : Bailey & love 25/e p797', 'role': 'assistant'}]