This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Glycogen, Subject name: Biochemistry
[{'content': "Which of the following substrates can't contribute to net gluconeogenesis in mammalian liver? \nSelect and explain. \nA. Alanine, B. Glutamate, C. Palmitate, D. Pyruvate", 'role': 'user'}, {'content': "Answer: C \nExplanation: Palmitate can't contribute to net gluconeogenesis in mammalian liver Palmitate Fatty acid with 16 carbon atoms Not a substrate of gluconeogenesis. Even chain fatty acids yield Acetyl CoA upon oxidation. Odd chain fatty acid acts as a substrates of gluconeogenesis Propionyl CoA- the product of their oxidation can enter TCA cycle through formation of succinyl CoA Alanine, pyruvate and glutamate are glucogenic.", 'role': 'assistant'}]