This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Surgery
[{'content': 'True about early stages of GERD \nSelect and explain. \nA. Increased number of TLOSRs, B. Increased LOS pressure, C. Shoening of LOS, D. Loss of intra abdominal oesophagus', 'role': 'user'}, {'content': 'Answer: A \nExplanation: In normal circumstances, the LOS transiently relaxes as a coordinated pa of swallowing, as a means of allowing vomiting to occur and in response to stretching of the gastric fundus, paicularly after a meal to allow swallowed air to be vented. Most episodes of physiological reflux occur during postprandial transient LOS relaxations (TLOSRs). In the early stages of GORD, most pathological reflux occurs as a result of an increased number of TLOSRs rather than a persistent fall in overall sphincter pressure. In more severe GORD, LOS pressure tends to be generally low, and this loss of sphincter function seems to be made worse if there is loss of an adequate length of intraabdominal oesophagus.Ref: Bailey and Love 27e pg: 1076', 'role': 'assistant'}]