This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Fungal Drugs, Subject name: Pharmacology
[{'content': 'If amphotericin B is administered, the patient should not be premedicated with: \nSelect and explain. \nA. Diphenhydramine, B. Ibuprofen, C. Prednisone, D. Atazanavir', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Amphotericin B infusion is associated with Acute Reaction which consists of chills, fever, aches and pain all over, nausea, vomiting and dyspnoea lasting for 2- 5 hour, probably due to release of cytokines (IL, TNFa). Therefore to prevent this reaction, patient should be premedicated with: H1 antihistaminics like diphenhydramine NSAIDs like ibuprofen Steroids like prednisone', 'role': 'assistant'}]