This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Epilepsy, Subject name: Pharmacology
[{'content': 'Which is gender specific adverse effect of valproate \nSelect and explain. \nA. PCOD, B. Weight gain, C. Alopecia, D. Hepatotoxicity', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Valproate Adverse effects a) Hepatotoxicity Due to a metabolite of valproate. This metabolite is produced more if given with carbamazepine like drugs. So they produce more hepatotoxicity b) Pancreatitis c) Polycystic ovarian disease', 'role': 'assistant'}]