This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: ETC, Subject name: Biochemistry
[{'content': 'Which of the following is a physiological uncoupler of oxidative phosphorylation: \nSelect and explain. \nA. 2, 4dinitrophenol, B. Cyanide, C. Thermogenin, D. Cyanide', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Uncoupler: Uncoupler means electron flow (oxidation) is occurring but phoshorylation is not occurring. This will lead to reduced ATP formation as phosphorylation is not occurring. It will stimulate electron transpo in order to produce more ATPs. Thermogenin, a protein present in brown fat, is a natural/physiological uncoupler of ETC. This is responsible for non-shivering thermogenesis. ADDITIONAL EDGE: Other uncouplers of ETC are:', 'role': 'assistant'}]