This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: ENT
[{'content': 'Neurofibromatosis type 2 is associated with: \nSelect and explain. \nA. B/L acoustic neuroma, B. Cafe-au-lait spots, C. Chromosome 22, D. All', 'role': 'user'}, {'content': 'Answer: D \nExplanation: B/L acoustic neuromas are a hallmark of Neurofibromatosis 2 Neurofibromatosis Type 2 is an autosomal dominant highly penetrant condition Gene for NF-2 is located on chromosome 22q. Patients with NF2 present in second and third decade of life, rarely after the age of 60. M/C symptom/Presenting symptom = Hearing loss Skin tumors are present in nearly two thirds of patients of NF-2 -Current Otolaryngology 3/e', 'role': 'assistant'}]