This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of nucleic acids, Subject name: Biochemistry
[{'content': 'Unwinding of DNA is done by \nSelect and explain. \nA. DNA polymerase, B. DNA primase, C. Helicase, D. DNA ligase', 'role': 'user'}, {'content': 'Answer: C \nExplanation: In addition to binding to the nucleosome, the H1 protein binds to the "linker DNA" (approximately 20-80 nucleotides in length) region between nucleosomes, helping stabilize the zig-zagged 30 nm chromatin fiber Ref-Sathyanarayana 4/e p360', 'role': 'assistant'}]