This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hypeension, Arrhythmias, Dyslipidemia, Subject name: Pharmacology
[{'content': 'Which antihypeensive is a prodrug and is conveed to its active form in brain? \nSelect and explain. \nA. Clonidine, B. Methyl dopa, C. Minoxidil, D. Nitroprusside', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Both methyldopa and minoxidil are prodrugs. Conversion of methyl dopa to a-methylnorepinephrine takes palce in the brain. Minoxidil is activated to minoxidil sulphate (by phase II reaction) in the periphery.', 'role': 'assistant'}]