This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
[{'content': 'What is the mechanism of action of Fluconazole? \nSelect and explain. \nA. Inhibits fungal mitosis, B. Inhibits lanosterol 14 demethylase, C. Inhibits squalene epoxidase, D. Inhibit ß1,3 glucan synthase', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Ref. KDT. Page. 793\nFluconazole\n\nThey inhibit the fungal cytochrome P450 enzyme ‘lanosterol 14-demethylase’ and thus impair ergosterol synthesis leading to a cascade of membrane abnormalities in the fungus.\nlower affinity for mammalian CYP450 enzymes and lesser propensity to inhibit mammalian sterol synthesis – causes less side effects\nIt is a water-soluble triazole having a wider range of activity\nIndications include cryptococcal meningitis, systemic and mucosal candidiasis in both normal and immunocompromised patients, coccidioidal meningitis and histoplasmosis', 'role': 'assistant'}]