This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pharmacology, Subject name: Pharmacology
[{'content': 'Which of the following statement is true regarding Fixed Dose Combination of drugs \nSelect and explain. \nA. Adverse effect of one drug may be reduced by the other drug, B. Two drugs with different pharmacokinetics can be combined easily, C. Dose of one drug can be altered independently as per requirement, D. Adverse effect can be ascribed to a single drug', 'role': 'user'}, {'content': "Answer: A \nExplanation: Fixed Drug Combination (FDC) Two different drug moieties are combined into a single pharmaceutical formulation. * As a rule, two drugs are ideal for combination into a FDC only when they have comparable pharmacokinetics. E.g: Cotrimoxazole = Sulfamethoxazole (t1/2 -11h) + Trimethoprim(t1/2 - 10h) Syndopa = Levodopa (t1/2 -1.7h) + Carbidopa (t1/2 -2h) Ref:- HL & KK Sharma's Principles of Pharmacology 3rd Ed; Pg.No: 57-8", 'role': 'assistant'}]