This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Interstitial lung diseases, Subject name: Pathology
[{'content': 'All of the following statement are true regarding silicosis, except: \nSelect and explain. \nA. Crystalline forms are much more fibrogenic, B. Phagocytosed silica crystals activate the inflammasome, leading to the release of inflammatory mediators, paicularly IL-2 and TNF, C. As the disease progresses, nodules coalesce into hard, collagenous scars, D. Histologic examination reveals the hallmark lesion characterized by a central area of whorled collagen fibers with a more peripheral zone of dust-laden macrophages.', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Silica occurs in both crystalline and amorphous forms, but crystalline forms (including quaz, cristobalite, and tridymite) are much more fibrogenic. After inhalation, the paicles are phagocytosed by macrophages. The phagocytosed silica crystals activate the inflammasome, leading to the release of inflammatory mediators, paicularly IL-1 and IL-18. As the disease progresses, these nodules coalesce into hard, collagenous scars. Histologic examination reveals the hallmark lesion characterized by a central area of whorled collagen fibers with a more peripheral zone of dust-laden macrophages.', 'role': 'assistant'}]