This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Disorders of Amino acid Metabolism, Subject name: Pediatrics
[{'content': 'Hyperuricemia is caused in newborn due to defect in: \nSelect and explain. \nA. Adenosine deaminase, B. Ornithine transcarbamylase, C. Xanthine oxidase, D. Hypoxanthine guanine ribosyltransferase', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Plasma uric acid is elevated in Lesch Nyhan disease (Hypoxanthine guanine ribosyltransferase deficiency) Xanthine oxidase deficiency- plasma uric acid | Adenosine deaminase deficiency leads to hypouricemia. Ornithine transcarbamylase deficiency- | ammonia', 'role': 'assistant'}]