This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'A newborn baby presented with profuse bleeding from umbilical stump after bih. Probable diagnosis is: \nSelect and explain. \nA. Factor- XIII deficiency, B. VWF deficiency, C. Factor-XII deficiency, D. Glanzmann thrombasthenia', 'role': 'user'}, {'content': "Answer: A \nExplanation: Congenital factor XIII deficiency is a rare autosomal recessive disease usually associated with a severe bleeding diathesis. Bleeding typically is delayed, because clots form normally but are susceptible to fibrinolysis. Umbilical stump bleeding is characteristic, and there is a high risk of intracranial bleeding. Replacement can be accomplished with FFP, cryoprecipitate, or a factor XIII concentrate. Ref: Gonzalez E.A., Jastrow K.M., Holcomb J.B., Kozar R.A. (2010). Chapter 4. Hemostasis, Surgical Bleeding, and Transfusion. In F.C. Brunicardi, D.K. Andersen, T.R. Billiar, D.L. Dunn, J.G. Hunter, J.B. Matthews, R.E. Pollock (Eds), Schwaz's Principles of Surgery, 9e.", 'role': 'assistant'}]