This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Medicine
[{'content': 'HBV replication is indicated by - \nSelect and explain. \nA. HBV DNA, B. DNA polymerase, C. HBeAg, D. IgMAnti-HBc', 'role': 'user'}, {'content': "Answer: C \nExplanation: Hepatitis B e antigen Hepatitis B e antigen (HBeAg) is an indicator of viral replication. In acute hepatitis B it may appear only transiently at the outset of the illness; its appearance is followed by the production of antibody (anti-HBe). The HBeAg reflects active replication of the virus in the liver. Chronic HBV infection (see below) is marked by the presence of HBsAg and anti-HBc (IgG) in the blood. Usually, HBeAg or anti-HBe is also present; HBeAg indicates continued active replication of the virus in the liver. The absence of HBeAg usually implies low viral replication; the exception is HBeAg-negative chronic hepatitis B (also called 'pre-core mutant' infection, ), in which high levels of viral replication, serum HBV-DNA and hepatic necroinflammation are seen, despite negative HBeAg. Ref Davidson edition23rd pg 875", 'role': 'assistant'}]