This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: JIPMER 2018, Subject name: Pharmacology
[{'content': 'Mechanism of action of Temozolomide is : \nSelect and explain. \nA. Alkylation of DNA, B. Inhibition of topoisomerase, C. Microtubule inhibition, D. Proteasome inhibition', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Temozolomide is an alkylating agent . It is the drug of choice for brain tumors.Other alkylating agents are:* If: Ifosfamide* Bus: Busulfan* Not: Nitrosoureas* Present: Procarbazine* Take: Temozolamide* My: Mephalan, Mechlorethamaide* Cycle: CyclophosphamideTopoisomerase inhibitor is Etoposide.Microtubule inhibitors are Vincristin, Vinblastin.Proteosome inhibitors are Boezomib.', 'role': 'assistant'}]