This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Pathology
[{'content': 'In Hereditary spherocytosis an inherited abnormality is seen in which of the following red blood cell component- \nSelect and explain. \nA. A-globin chain, B. a-globin chain, C. Phosphatidylinositol glycan A, D. Spectrin', 'role': 'user'}, {'content': 'Answer: D \nExplanation: HS is caused pathogenic mutations that affect ankyrin , band 3, spectrin , or band 4.2. Which causes insufficiency of membrane skeletal components. Ref :Robbins pathologic basis of disease ; south east asia edition ;pg:633', 'role': 'assistant'}]