This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Drugs with high plasma protein binding have: \nSelect and explain. \nA. Short duration of action, B. Less drug interactions, C. Lower volumes of distribution, D. All of the above', 'role': 'user'}, {'content': 'Answer: C \nExplanation: -\xa0Plasma protein binding of drugs causes\n\n\xa0 \xa0Lower volume of distribution\n\xa0 \xa0Longer duration of action\n\xa0 \xa0Increased drug interactions- due to drug displacement for the binding site.', 'role': 'assistant'}]