This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of carbohydrate, Subject name: Biochemistry
[{'content': 'Within the RCBC, hypoxia stimulates glycolysis by which of the following regulating pathways? \nSelect and explain. \nA. Hypoxia Stimulates pyruvate dehydrogenase by increased 2, 3 BPG, B. Hypoxia inhibits hexokinase, C. Hypoxia stimulates release of all Glycolytic enzymes from Band 3 on RBC membrane, D. Activation of the regulatory enzymes by high PH', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Rapapo Leubering Cycle (BPG Shunt) In the erythrocytes, step 6 of glycolysis is bypassed. Bis phosphoglycerate mutase conves 1,3- bisphosphoglycerate (BPG) to 2,3-BPG. Then BPG phosphatase removes the phosphate group to form 3-phosphoglycerate Significance of BPGThe 2,3-BPG combines with hemoglobin and reduces the affinity towards oxygen. So, in presence of 2,3-BPG, oxyhemoglobin will unload oxygen more easily in tissues.Under hypoxic conditions, the 2,3-BPG concentration in the RBC increases, thus oring the release of oxygen to the tissues even when PO2 is lowThe compensatory increase in 2,3-BPG in high altitudes ors oxygen dissociation. BPG is increased in fetal circulation.In this shunt pathway, no ATP is generatedRef: DM Vasudevan, 7th edition, page no: 100', 'role': 'assistant'}]