This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'Percentage of dose given as basal insulin in bolus basal regimen in children is? \nSelect and explain. \nA. 0 – 25%, B. 25 – 50%, C. 50 – 75%, D. None of these', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Several factors influence the initial daily insulin dose per kilogram of body weight.\nThe dose is usually higher in pubertal children.\nIt is higher in those who have to restore greater deficits of body glycogen, protein, and fat stores and who, therefore, have higher initial caloric capacity.\nOn the other hand, most children with new-onset diabetes have some residual a-cell function (the "honeymoon" period), which reduces exogenous insulin needs.\nResidual (3-cell) function usually fades within a few months and is reflected as a steady increase in insulin requirements and wider glucose excursions.\nThe initial insulin schedule should be directed toward the optimal degree of glucose control in an attempt to duplicate the activity of the (3-cell).\nAcceptable glucose control can be obtained with new insulin analogs used in a basal-bolus regimen, that is, with slow-onset, long-duration background insulin for between-meal glucose control and rapid-onset insulin at each meal.\n\n\n\n\nBolus Insulin\n\n\nAge(yr)\nTarget glucose(Mg/dl)\nTotal daily insulin(U/kg/d)\nBasal insulin,% of total daily dose\nUnits added per 100 mg/dl above target\nUnits added per 15g at meal\n\n\n0 - 5\n100 - 200\n0.6 - 0.7\n25 - 30\n0 - 50\n0 - 50\n\n\n5 - 12\n80 - 150\n0.7 - 1.0\n40 - 50\n0 - 75\n0 - 75\n\n\n12 - 18\n80 - 150\n1.0 - 1.2\n40 - 50\n1 - 2\n1 - 2', 'role': 'assistant'}]