This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: CLL & CML, Subject name: Medicine
[{'content': 'First line treatment of T315I mutation in CML management is? \nSelect and explain. \nA. Bosutinib, B. Tofacitinib, C. Ponatinib, D. Nilotinib', 'role': 'user'}, {'content': 'Answer: C \nExplanation: T315I mutation is a mutation in the critical BCR-ABL kinase in the ATP-binding pocket This prevents imatinib binding and hence leads to resistance to imatinib, nilotinib, bosutinib, and dasatinib. Only drug effective for T315I mutation CML = Ponatinib. Otherwise DOC CML= Imatinib. DOC for Imatinib resistant CML = Bosutinib DOC in case of failure of > 2 Tyrosine kinase inhibitor = OMACETAXINE', 'role': 'assistant'}]