This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Nephrotic and Nephritic syndrome, Subject name: Medicine
[{'content': 'ADTKD patients have a defect in which of the following genes? \nSelect and explain. \nA. MUC1, B. PKD1, C. BBS 1, D. NPHS1', 'role': 'user'}, {'content': 'Answer: A \nExplanation: AD Tubulointerstitial Kidney Disease - Defect in MUC1 & UMOD NPHS1: Related to development of Congenital/Finnish Nephrotic Syndrome NPHS2: Related to pediatric- infantile Nephrotic Syndrome. PKD1/2: ADPKD BBS1:Bardet Biedl Syndrome', 'role': 'assistant'}]