This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Blood, Subject name: Pathology
[{'content': 'Autosplenectomy is seen in? \nSelect and explain. \nA. Hereditary spherocytosis, B. G6 PD deficiency, C. Sickle cell anemia, D. Thalassemia major', 'role': 'user'}, {'content': 'Answer: C \nExplanation: ANSWER: (C) Sickle cell anemiaREF: Harrisons Internal Medicine 17th edition Chapter 60. Enlargement of Lymph Nodes and Spleen, CMDT 2009 chapter 13 Blood Disorders > AnemiasPatients with sickle cell disease often suffer from autosplenectomy as a result of splenic destruction by the numerous infarcts associated with sickle cell crises during childhood.Indeed, the presence of a palpable spleen in a patient with sickle cell disease after age 5 suggests a coexisting hemoglobinopathy, e.g., thalassemia or hemoglobin C', 'role': 'assistant'}]