This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Major Depression, Subject name: Psychiatry
[{'content': 'Which of the following is true about depression: \nSelect and explain. \nA. Increased Serotonin and Norepinephrine, B. Increased serotonin decreased Norepinephrine, C. Decreased serotonin and Norepinephrine, D. Decreased serotonin increased Norepinephrine', 'role': 'user'}, {'content': "Answer: C \nExplanation: Ans. (c) Decreased serotonin and NorepinephrineRef : Harrison 19th ed. / 2714-2715* Depression is one of the mood disorders* It is considered as most common psychiatric disorder.* Most commonly seen in middle age females. M:F ratio= 1:2* Neurotransmitters involved are serotonin and NE. Both are decreased.Diagnostic Criteria of DepressionMajor CriteriaMinor CriteriaPersistent sadness of moodLoss of appetiteLoss of pleasure in activitiesSleep disturbanceEasy fatiguabilityDecreased libido| ConcentrationIdeas of guilt, worthlessness, hopelessnessSuicidal ideas.Depression Category on Basis of Severity* Mild Depression :2 major + 2 minor* Moderate Depression :2 major + 3 minor* Severe Depression : 2 major + 4 minorAlso KnowDiseaseRelated NeurotransmitterAlzheimer's diseaseAcetyl cholineDepressionNorepinephrine, Serotonin (5-HT) & dopamine are DECREASEDOCNSerotonin (5 HT)SchizophreniaDopamine, Serotonin & Norepinephrine are INCREASED", 'role': 'assistant'}]