This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Lipids, Subject name: Biochemistry
[{'content': 'A patient was diagnosed with isolated increase in LDL. His father and brother had the same disease with increased cholesterol. The likely diagnosis is: \nSelect and explain. \nA. Familial type III hyperlipoproteinemia, B. Abetalipoproteinemia, C. Familial LPL deficiency (type I), D. LDL receptor mutation', 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans. D. LDL receptor mutation(Ref: Harrison 19/e, Table 356.3)Frederickson's Classification of HyperlipoproteinemiaPhenotypeType IType IIType IIIMolecular defectLipoprotein lipase apo CIILDL receptor defect apo B100 defective Apo E defectGenetic nomenclatureFamilial chylomicronemia syndromeFamilial Hypercholesterolemia Familial Defective apo BFamilial dysbetalipoproteinemiaClinical featuresEruptive Xanthoma Pancreatitis Lactescent Plasma No Coronary/ Peripheral AtherosclerosisTendon Xanthoma Tuberous Xanthoma No Pancreatitis No Lactescent Plasma Coronary atherosclerosis+++Peripheral Atherosclerosis +Tuberoeruptive XanthomaNo Pancreatitis Coronary atherosclerosis +++ Peripheral Atherosclerosis +Lipid elevatedTriacylglycerol NB: Cholesterol normalCholesterolNB: Triacylglycerol normalCholesterol triacylglycerolLipoprotein elevatedChylomicronLDLChylomicron remnant VLDL remnant", 'role': 'assistant'}]