This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: HAEM synth and porphyrias, Subject name: Biochemistry
[{'content': 'Which of the following enzyme of Heme synthesis is located in mitochondria? \nSelect and explain. \nA. ALA synthase, B. ALA dehydratase, C. Uroporphyrinogen I synthase, D. Uroporphyrinogen decarboxylase', 'role': 'user'}, {'content': 'Answer: A \nExplanation: First reaction and the last 3 reactions of heme synthesis take place in the mitochondria. The rest of them takes place in cytosol. Figure: Heme synthesis occuring in mitochondrion & cytosol', 'role': 'assistant'}]