This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Eczema and related disorders, Subject name: Dental
[{'content': 'A 25 year old male presents with recurrent lip edema to the OPD. On performing lab investigations, it revealed |C4, |C1-INH levels, |C1-INH function, normal C1q levels. What is the most probable diagnosis? \nSelect and explain. \nA. Hereditary angioedema Type 1, B. Hereditary angioedema Type 2, C. Acquired angioedema Type 1, D. Acquired angioedema Type 2', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Hereditary angioedema(HAE) Disorder characterized by recurrent episodes of severe swelling (angioedema). 3 main types of HAE. Type I and II are caused by a mutation in the SERPING1 gene that makes the C1 inhibitor protein while type III is often due to a mutation of the factor KhII gene. This results in increased amounts of bradykinin which promotes swelling. Distinguishing b/w HAE & AAE( Acquired angioedema): C1q levels normal-HAE C1q levels low-AAE Type 1 HAE-Low C1-INH level & low C4 level Type 2 HAE- Normal or elevated C1-INH level & low C4 level. Function of C1-INH is reduced in both type 1 & 2 HAE.', 'role': 'assistant'}]