This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Progressive damage in a cell including the DNA leads to: \nSelect and explain. \nA. Necrosis or Apoptosis, B. Atrophy, C. Metaplasia, D. Calcification', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Decreased nutrients lead to atrophy.\nChronic irritation leads to metaplasia.', 'role': 'assistant'}]