This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Types of Genetic Disorders, Subject name: Pediatrics
[{'content': 'Single gene defect causing multiple unrelated problems is called? \nSelect and explain. \nA. Pleiotropism, B. Pseudodominance, C. Penetrance, D. Anticipation', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Pleotropism refers to single gene defect causing multiple traits. Penetrance- extent to which a paicular gene or set of genes is expressed in the phenotypes of individuals carrying it Pseudodominance- sudden appearance of a recessive phenotype in a pedigree, due to deletion of a masking dominant gene Anticipation- disease manifestation worsen from 1 generation to next', 'role': 'assistant'}]