This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': "Which of the following differentiates Hodgkin's lymphoma from non Hodgkin's lymphoma? \nSelect and explain. \nA. Fever, night sweat, weight loss, B. Generalized lymphadenopathy, C. Elderly, D. Reed stern berg cells", 'role': 'user'}, {'content': 'Answer: D \nExplanation: In classic Hodgkin lymphoma, the neoplastic cell is the Reed-Sternberg (RS) cell. Reed-Sternberg cells comprise only 1-2% of the total tumor cell mass. Most Reed-Sternberg cells are of B-cell origin. The Reed-Sternberg cells consistently express the CD30 (Ki-1) and CD15 (Leu-M1) antigens. Age-specific incidence rates of Hodgkin lymphoma and non-Hodgkin lymphoma have a bimodal distribution in both sexes, peaking in young adults (aged 15-34 y) and older individuals (>55 y). Asymptomatic lymphadenopathy may be present in both. Constitutional symptoms (eg, unexplained weight loss, fever, night sweats) are present in 40% of patients.', 'role': 'assistant'}]