This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Cancer, Subject name: Pharmacology
[{'content': 'Most emetogenic anti CA drug: \nSelect and explain. \nA. 5 FU, B. Methotrexate, C. Cisplatin, D. All', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ref: Katzung 14th ed. pg. 956; KDT, 6th ed. pg. 828* Cisplatin is a platinum coordination complex that is hydrolyzed intracellularly to produce a highly reactive moiety which causes cross linking of DNA by platinum compound.* It is a highly emetic drug. Antiemetics are routinely administered before infusing cisplatin.* DOC for cisplatin induced vomiting: Ondansetron* Major s/e of cispltin: Ototoxicity and nephrotoxicity.', 'role': 'assistant'}]