This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pediatrics
[{'content': 'A 1 -year-old child is brought to the hospital with thyroid swelling. The child has abnormal weight gain and has poor activities. His TSH is found raised and T4 is very low. Which of the following is most likely cause of his disease? \nSelect and explain. \nA. Hypothalamic disease, B. Thyroid dysgenesis, C. Dyshormonogenesis, D. End organ receptor insensitivity', 'role': 'user'}, {'content': "Answer: C \nExplanation: c. Dyshormonogenesis(Ref: Nelson's 20/e p 2669-2773, Ghai 8/e p 516-521)Most common cause of congenital hypothyroidism in a child with goiter is Thyroid dyshormonogenesis.", 'role': 'assistant'}]