This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pharmacology, Subject name: Pharmacology
[{'content': 'Zero-order kinetics occur in the following drug with high dose \nSelect and explain. \nA. Phenytoin and Theophylline, B. Digoxin and Propranol, C. Amiloride and Probenecid, D. Lithium and Theophylline', 'role': 'user'}, {'content': 'Answer: A \nExplanation: zero order kinetics -the rate of elimination remains constant irrespective of drug concentration, clearance decreases with increase in concentration, or a constant amount of drug is eliminated in unit time The elimination of some drugs changes from first order to zero order at higher doses eg ; Phenytoin, Tolbutamide, Theophylline, Warfarin, DIGOXIN, aspirin ref; KD Tripathi Pharmacology 7th edition (page no;31 )', 'role': 'assistant'}]