This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Virology, Subject name: Microbiology
[{'content': 'In chronic Hepatitis B infection, which one of the following markers is indicative of active viral replication and the corresponding risk of disease transmission? \nSelect and explain. \nA. Hbe antigen, B. HBs antigen, C. Anti - Hbe, D. Anti - HBs', 'role': 'user'}, {'content': 'Answer: A \nExplanation: HBeAg indicates active intrahepatic viral replication, reflecting high infectivity REF:<\\p> ANATHANARAYANAN MICROBIOLOGY NINTH EDITION PAGE.547', 'role': 'assistant'}]