This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'The risk of developing infective endocarditis is the least in a patient with - \nSelect and explain. \nA. Small VSD, B. Severe aortic regurgitation, C. Severe mitral regurgitation, D. Large ASD', 'role': 'user'}, {'content': 'Answer: D \nExplanation: None', 'role': 'assistant'}]