This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'NSAIDS cause gastric ulcer because- \nSelect and explain. \nA. They inhibit COX - 2 enzyme, B. They inhibit mucus production, C. They increase HCI production, D. They delay gastric emptying', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e., They inhibit mucus production o Normally, gastric mucosal PGs are produced by COX - 1. o Prostaglandins function as natural ulcer protectives by enhancing gastric mucus and HCO3- production, as well as by improving mucosal circulation and health. The ulcerogenic action of NSAIDs may be due to loss of this protective influence. o PGE analogues are cytoprotective at low doses and inhibit gastric acid secretion at higher doses. NSAIDs inhibit prostaglandin secretion and thus antagonizes its cytoprotective effect. o Misoprostol is used in NSAIDs induced ulcers.", 'role': 'assistant'}]