This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: miscellaneous, Subject name: Pathology
[{'content': "The typical 'Orphan-Annie eye' nucleus is described in - \nSelect and explain. \nA. Serous cystadenocarcinoma of ovary, B. Renal cell carcinoma, C. Papillary carcinoma of thyroid, D. Seminoma", 'role': 'user'}, {'content': 'Answer: C \nExplanation: Papillary carcinoma: Accounts for 85% of thyroid malignancy in iodine-deficient areas Most common thyroid cancer in children and in persons exposed to external radiation Most often in women between 30-40 years Excellent prognosis Characteristic nuclear features: Ground glass (Orphan Annie) nuclei pseudoinclusions Nuclear grooves. Nuclear features are used as diagnostic criteria even in the absence of papillae. Papillary carcinoma: Most commonly spreads through lymphatics. Papillary carcinoma: Metastasize through lymphatics and have an excellent prognosis.', 'role': 'assistant'}]