This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology and breast, Subject name: Surgery
[{'content': 'Prognostic stage groups in carcinoma breast include all except \nSelect and explain. \nA. Tumour size, B. Grade, C. HER-2 status, D. Age', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Prognostic stage groups include TNM plus grading, and status of biomarkers HER-2, ER, and PR Ref: AJCC 8th edition', 'role': 'assistant'}]