This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemical Mediators and Regulators of Inflammation, Subject name: Pathology
[{'content': 'Fever occurs due to - \nSelect and explain. \nA. IL 1, B. Endoephin, C. Enkephalin, D. Histamine', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., IL1 Pyrogeneso Pyrogenes are substances that cause fever.o Pyrogens may be exogenous or endogenous* Exogenous- Bacterial toxins* Endogenous- IL0-l,TNF-a, IL-6, Interferons, Cilioiy's neurotropic factoro These pyrogenes increase the level of PGE2 in the hypothalamus that elevates the thermoregulatory set point and causes fever.", 'role': 'assistant'}]