This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
[{'content': 'An alpha helix of a protein is most likely to be disrupted if a missense mutation introduces the following amino acid within the alpha helical structure: \nSelect and explain. \nA. Alanine, B. Tyrosine., C. Aspaic acid, D. Glycine', 'role': 'user'}, {'content': 'Answer: B \nExplanation: * The alpha helix is disrupted by introduction of following amino acids. 1. Proline - Most common 2. Charged amino acids like H - Histidine A - Aspaic acid A - arginine G - Glutamic acid Ly-Iysine 3. Amino acids with bulky side chains if present in large number eg - (a) Tryptophan (b) Valine (c) Isoleucine', 'role': 'assistant'}]