This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Genetics, Subject name: Pathology
[{'content': 'The phenomenon where subsequent generations are at risk of earlier and more severe disease is known as: \nSelect and explain. \nA. Anticipation, B. Pleiotropy, C. Imprinting, D. Mosaicism', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Anticipation refers to the phenomenon in which clinical features of a genetic disease worsen with each successive generation. Eg : Fragile X syndrome and Huntington disease (CAG repeats).', 'role': 'assistant'}]