This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Replication, Subject name: Biochemistry
[{'content': 'Enzyme that produces single strand nicks in DNA: \nSelect and explain. \nA. DNA polymerase I, B. DNAase I, C. Polynucleotide kinase, D. l - exonuclease', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Deoxyribonuclease I (DNAase I) Acts on single-stranded DNA, double-stranded DNA, and chromatin. Makes single stranded cuts in nearly any segment of DNA i.e. has low sequence specificity. Digest DNA that is not protected/not bound by protein, into its component deoxynucleotides. Used in DNA Foot Printing. E.g. (DNase I) nick the single strands of double-stranded DNA.', 'role': 'assistant'}]