This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Genetic and genetic disorders, Subject name: Pediatrics
[{'content': 'Neurofibromatosis 1 criteria include all except: \nSelect and explain. \nA. Brain tumor, B. Acoustic neuromas, C. Dysplasia of the sphenoidal and tibial bone, D. Cafe-au-lait spots', 'role': 'user'}, {'content': 'Answer: B \nExplanation: In Neurofibromatosis 1 (NF1), two or more of the following clinical manifestations are present: Six or more Cafe-au-lait macules Axillary and inguinal freckling Two or more iris Lisch nodules Two or more neurofibromas or 1 plexiform neurofibroma A distinctive osseous lesion such as sphenoidal and tibial dysplasia Optic gliomas A 1st degree relative with NF1 Ref: Nelson textbook of pediatrics 21st edition pgno: 3141', 'role': 'assistant'}]