This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunology, Subject name: Microbiology
[{'content': "Most common cause of chronic granulomatous disease in children is - \nSelect and explain. \nA. Myeloperoxidase deficiency, B. Defective phagocytosis, C. Defective H2 O2 production, D. Job's disease", 'role': 'user'}, {'content': "Answer: C \nExplanation: Chronic granulomatous disease stas in early life. Chronic suppurative lesions develop in skin and lymph nodes with hepatoslpenomegaly, progressive infiltration of lungs and granulomatous septic ostemyelitis. Diminished H2 02 production affect is the main reason for the bactericidal defect in this disease. Thus leukocyte do not undergo degranulation following phagocytosis. Reference : Anathanarayan & paniker's 9th edition, pg no:175 <\\p>", 'role': 'assistant'}]