This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'True about alpha-1 antitrypsin deficiency, is/are -a) Autosomal dominantb) Pulmonary emphysemac) Diastase resistant hepatic cellsd) Hepatic cells are orcein stain positivee) Associated with berry aneurysm \nSelect and explain. \nA. bc, B. c, C. ac, D. ad', 'role': 'user'}, {'content': "Answer: A \nExplanation: α\u200b1\xa0-anti-trypsin deficiency\n\nα\u200b1 -anti-trypsin deficiency, is an autosomal recessive disease marked by abnormally low levels of (serum) of this major protease inhibitor (Pi)\nDeficiency of the enzyme leads to pulmonary emphysema (panacinar)\nLiver is characterised by :\nPresence of round to oval cytoplasmic globular inclusions in hepatocytes which on H and E stains acidophilic and indistinctly demarcated from surrounding cytoplasm.\nThey are PAS positive and diastase resistant\nIn most part, only distinctive feature is globules infrequently-fatty change, mallory bodies.\nNeonatal hepatitis with cholestasis\nFatty change (steatosis)\nCirrhosis may develop which can transform into heptocellular carcinoma.\n\nFollowing information has been added in 8th/e of Robbins \n\nIn addition, cutaneous panniculitis, arterial aneurysm, bronchiectasis and wegner's granulomatosis can occur in α\u200b1- antitrypsin deficiency.", 'role': 'assistant'}]