This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anaesthesia, Subject name: Anaesthesia
[{'content': 'Which of the following inhalational agent is contraindicated in renal disease? \nSelect and explain. \nA. Methoxyflurane, B. Sevoflurane, C. Desflurane, D. Isoflurane', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Methoxyflurane produces inorganic fluoride, which was responsible for the sporadic incidence of nephrotoxicity (i.e., high-output renal failure) after prolonged anesthesia Basics of anesthesia 7e pg:95', 'role': 'assistant'}]