This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Childhood tumors, Subject name: Pediatrics
[{'content': 'The poor prognostic factor associated with ALL in children is \nSelect and explain. \nA. Total leucocytle count 4000-100000, B. Age less than 2 years, C. Testicular involvement, D. Blast in Peripheral Smear', 'role': 'user'}, {'content': 'Answer: C \nExplanation: The standard features are age and WBC at diagnosis, with infants (less than one year), adolescents (greater than nine years), and children with WBC above 50,000/ml being at higher risk. Ceain chromosomal abnormalities are also strong predictors; in paicular, the Philadelphia chromosome and MLL gene rearrangements (especially in infants) are adverse features, while TEL-AML1 is orable. It is impoant to note, however, that even the most impoant known predictors explain only a small propoion of the variability in outcome. Testicular involvement Is a poor prognostic factor for ALL Reference: GHAI Essential pediatrics, 8th edition', 'role': 'assistant'}]