This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pharmacokinetics, Subject name: Pharmacology
[{'content': "Which of the following statements is TRUE regarding termination of action of a drug? \nSelect and explain. \nA. Drugs must be excreted from the body to terminate their action, B. Metabolism of drugs always abolishes their pharmacologic activity, C. Hepatic metabolism and renal excretion are the two most impoant mechanisms involved, D. Distribution of a drug out of blood stream terminates the drug's effects", 'role': 'user'}, {'content': 'Answer: C \nExplanation: * Action of a drug can be terminated either by hepatic metabolism or by renal excretion. Other pathways like excretion in sweat or saliva plays minor roles. * Most of the drugs are inactivated by metabolism. However, some drugs may be activated from inactive form (prodrugs) and others may produce active metabolites. * Some drugs may act away from blood e.g. digoxin leaves bloodstream and enters the hea to produce its action.', 'role': 'assistant'}]