This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Pathology
[{'content': 'Poor prognostic indicator in ALL- \nSelect and explain. \nA. Age <2 year, B. TLC4000-10,000, C. Presence of testicular involvement at presentation, D. Presence of blasts in peripheral smear', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Poor prognostic factors in ALL Age less than two years, largely because of the strong association of infantile ALL with translocation involving MLL gene. Presentation in adolescence oor adulthood Peripheral blood blast count greater than 100000 which probably denotes a high tumour burden. Reference : Robbins and Cotran Pathologic basis of disease.South Asia Edition volume 1.page no. 592', 'role': 'assistant'}]