This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NEET 2018, Subject name: Medicine
[{'content': 'Which of the following is true about factor V leiden mutation? \nSelect and explain. \nA. Increased bleeding tendency, B. Factor V becomes resistant to cleavage by protein C, C. Arginine to glycine substitution, D. Deficiency of factor V', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Factor V Leiden mutation is hypercoagulable disorder characterized by deep venous thrombosis and pulmonary thromboembolism. Factor V becomes resistant to cleavage by protein C. It occurs due to arginine to glutamate substitution. Factor V deficiency is known as Para hemophilia.', 'role': 'assistant'}]