This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Psychiatry
[{'content': 'Features of serotonin syndrome associated with SSRI & MAOIs are -a) Tremorsb) Agitationc) Cardiovascular collapse d) Hypothermiae) Suicidal tendency \nSelect and explain. \nA. abc, B. bc, C. acd, D. bcd', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Serotonin syndrome \n\nSerotonin syndrome refers to a dangerous and potentially fatal syndrome caused by excess synaptic serotonin levels due to use of serotonin potentiating drugs.\nThis condition is associated confusion, altered consciousness, hyperthermia, tremors, myoclonus, rigidity and hyperreflexia.\nDrugs causing serotonin syndrome are :-\n\n\nInhibiting 5-HT metabolism :- MAO inhibitors (e.g. tranylcypromine, phenelzine, meclobemide, selegilline)\nInhibit serotonin reuptake SSRIs, TCAs, amphetamine, cocaine, pethidine (mepridine),Pentazocin, MDMA, tramadol, Nefazodone, dextromethorphan.\nIncrease 5-HT release :- Amphetamine, cocaine, fenfluramine, MDMA, sibutramine.\nSerotonin Agonists Buspirone, lithium, LSD, Ergots (Dihydroergotamine), triptans (Sumitriptan), Piperazine.\nOther :- ECT, trazodone / Nafazodone, Carbamezapine.\n\nClinical features \n\nClinical features of serotonin syndrome are :-\n\n\n, Mental status :- altered consciousness, restlessness, insomnia, elevated mood, coma.\nNeurological:- Myoclonus, tremor, shivering, rigidity, hyper-reflexia, agitation, incordination, akathesia, mydriasis\nVital and autonomic:- Fever (hyperthermia), sweating, tachycardia & palpitation, tachypnea or dysnea, diarrhea, hypertension or hypotension, cardiovascular collapse.\n\nTreatment\n\nAggressive cooling and sedation with a benzodiazepine remain the basis of therapy.', 'role': 'assistant'}]