This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Enamel hypo-calciﬁcation and hypo-maturation of tooth is seen in: \nSelect and explain. \nA. Osteogenesis imperfecta, B. Dentinogenesis imperfecta, C. Tricho-dento-osseous syndrome, D. Turner tooth', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Tricho-Dento-Osseous Syndrome\xa0\nThe tricho-dento-osseous (TOP)\xa0syndrome is a hereditary condition, which chiefly involves the hair, teeth, and bones. The condition is inherited as an autosomal dominant disorder and the mutations are mapped to the DLX gene located at chromosome 17q21.3-q22. DLX gene plays a role in the development of craniofacial bone in the early embryogenesis. Later, it is expressed in structures that involve epithelial-mesenchymal interaction such as teeth, hair follicle, and skin.\nThe dental findings include yellow-brown discoloration of teeth, enamel hypoplasia, and severe attrition of enamel. Such defective enamel may be a cause for commonly occurring dental abscesses.\xa0Wide pulp chamber (taurdontism), especially involving the molars, has been reported.\nRadiographic Features\xa0\nIn dental X-rays, large pulp chambers are noticed, often in the molars.\xa0In addition, teeth may remain unerupted\xa0for long, leading to partial anodontia.\xa0\nKey Concept:\nA\xa0pattern\xa0of\xa0teeth\xa0alteration\xa0similar\xa0to\xa0amelogenesis imperfecta with taurodontism is seen in the systemic disorder,\xa0tricho-dento-osseous\xa0syndrome.\nReference:\xa0 Shafer’s Textbook of ORAL PATHOLOGY Eighth Edition page no 483', 'role': 'assistant'}]