This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Integrated QBank, Subject name: Unknown
[{'content': 'A 55-year-old female developed ESRD due to poorly controlled diabetes. She underwent dialysis 2-3 times a week. She was advised for kidney transplant which she received from cadaveric donor. She was put on immunosuppressive therapy with azathioprine, cyclosporine, methylprednisolone and anti-thymocyte globulin. Two weeks following the surgery, the patient was discharged on medications. 2 weeks later she presented to emergency with complaints of decreased urine output. On examination, her BP was noted to be 160/95 mm hg. The region of the graft is enlarged and is tender to touch. Lab investigations revealed serum creatinine of 4 mg/dl. Her differential diagnosis includes transplant rejection and drug toxicity. Which drug could be held responsible for the above clinical scenario? \nSelect and explain. \nA. Azathioprine, B. Cyclosporine, C. Methylprednisolone, D. ATG', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Cyclosporine: Immunosuppressive agent with efficacy in human organ transplantation treatment of graft-versus-host (GVH) disease after hematopoietic stem cell transplantation treatment of selected autoimmune disorders. Cyclosporine act at an early stage in the antigen receptor-induced differentiation of T cells and blocks their activation. Cyclosporine binds to cyclophilin (immunophilins). Toxicities are numerous and include Nephrotoxicity hypeension, hyperglycemia liver dysfunction hyperkalemia Altered mental status Seizures hirsutism. Cyclosporine uses: Cadaveric transplantation of the kidney, pancreas, and liver, and useful in cardiac transplantation. With methotrexate: Prophylactic regimen to prevent GVH disease after allogeneic stem cell transplantation. Autoimmune disorders Uveitis rheumatoid ahritis psoriasis asthma.', 'role': 'assistant'}]