This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: viral infection, Subject name: Medicine
[{'content': 'Which Anti-viral drug causes the below given condition : \nSelect and explain. \nA. Entecavir, B. Abacavir, C. Adefovir, D. Nelfinavir', 'role': 'user'}, {'content': 'Answer: D \nExplanation: PROTEASE INHIBITORS - These drugs have adverse effects on Fat metabolism and redistribution on prolonged intake resulting in LIPODYSTROPHY SYNDROME (Buffalo hump appearance , central obesity , metabolic syndrome etc) These drugs cause LIPODYSTROPHY SYNDROME by - | GLUCOSE | LIPIDS INSULIN RESISTANCE WT. GAIN. - These include drugs like: INDINAVIR RITONAVIR LOPINAVIR AMPRENAVIR FOS-AMPRENAVIR ATAZANAVIR (Lowest risk of Lipodystrophy syndrome but can cause hyperbilrubinemia) SAQUINAVIR NELFINAVIR Abacavir, Entecavir and Adefovir - NI (Nucleoside reverse transcriptase inhibitors)', 'role': 'assistant'}]