This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: vitamins, Subject name: Biochemistry
[{'content': 'Thiamin status of an individual can be detected by which of the following tests/enzymes in erythrocytes? \nSelect and explain. \nA. Transaldolase, B. Glucose-6-phosphatase, C. Transketolase, D. Enolase', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Severe thiamine deficiency is associated with: Decreased RBC transketolase activity this is the earliest manifestation seen even before clinical disturbances Thiamin is a cofactor of Transketolase pyruvate, alpha-ketoglutarate and lactate level in blood increases in thiamine deficiency ref: DM Vasudevan 8th ed page 467', 'role': 'assistant'}]