This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Pathology
[{'content': 'Progressive transformation of germinal centers (PTGC) is a precursor lesion of - \nSelect and explain. \nA. Hodgkins lymphoma, nodular sclerosis, B. Hodgkins lymphoma, mixed cellularity, C. Hodgkins lymphoma, lymphocytic predominant, D. Peripheral T cell lymphoma', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Lymphocytic predominance contains lymphocytic and histiocytic (L and H) variant. Thesse variants express B cell markers typical of germinal centre B cells. The IgH genes of L and H variant show evidence of ongoing somatic hypermutation,a modification that occurs only in germinal centre B cells. In 3%to5% of cases this type transforms in to a tumour resembling diffuse large B cell lymphoma. Reference; Robbins and Cotran Pathologic basis of disease.South Asia Edition volume 1.page no. 609,610', 'role': 'assistant'}]