This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hemoglobinopathies: Sickle cell anemia, Subject name: Pathology
[{'content': 'In hereditary spherocytosis, an inherited abnormality is seen in which of the following red blood cell component? \nSelect and explain. \nA. a-globin chain, B. b-globin chain, C. Phosphatidyl inositol glycan A, D. Spectrin', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Hereditary spherocytosis (HS) is caused by diverse mutations that lead to an insufficiency of membrane skeletal components. The pathogenic mutations most commonly affect ankyrin, band 3, spectrin, or band 4.2.', 'role': 'assistant'}]