This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Histamine causes all EXCEPT: \nSelect and explain. \nA. Aeriolar dilatation, B. Increased permeability of venules, C. Constriction of large aeries, D. Platelet aggregation', 'role': 'user'}, {'content': "Answer: D \nExplanation: Platelet aggregation REF: Robbin's pathology 7th edition page 63 Preformed histamine is present in mast cell granules and is released by mast cell degranulation in response to variety of stimuli. In humans histamine causes: Aeriolar dilatation Increased permeability of venules (however constricts large aeries) Via binding to H1 receptor on endothelial cells", 'role': 'assistant'}]