This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Biochemistry
[{'content': 'Increased blood levels of cholesterol that are seen in hypothyroidism are most likely due to \nSelect and explain. \nA. Decreased calorigenesis, B. Decreased production of LDL receptor in liver and the thus decreased clearance by liver, C. Decreased production of LDL receptor in the adipose tissue and increases release of cholesterol from adipose tissues, D. Increased breakdown of lipoproteins releasing releasing cholesterol in circulation', 'role': 'user'}, {'content': "Answer: C \nExplanation: Thyroid hormones induce the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, which is the first step in cholesterol biosynthesis.Moreover, triiodothyronine (T3) upregulates LDL receptors by controlling the LDL receptor gene activation. This T3-mediated gene activation is done by the direct binding of T3 to specific thyroid hormone-responsive elementsFuhermore, T3 controls the sterol regulatory element-binding protein-2 (SREBP-2), which in turn regulates LDL receptor's gene expression Ref: DM Vasudevan, 7th edition, page no: 336, 334, 676", 'role': 'assistant'}]