This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Drugs in Pregnancy, Subject name: Gynaecology & Obstetrics
[{'content': 'In terms of bih defect potential, the safest of the following drugs is \nSelect and explain. \nA. Alcohol, B. Isotretinoin (Accutane), C. Tetracyclines, D. Progesterones', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Alcohol sequelae include retardation of intrauterine growth, craniofacial abnormalities, and mental retardation. Isotretinoin, a drug for acne, is asoociated with congenital anomalies like Microtia, Micrognathia, cleft palate, thymic aplasia, CVS anomalies, NTDs Tetracyclines interfere with development of bone and can lead to stained teeth in children. Regarding progesterones use in pregnancy, controlled studies have failed to demonstrate a significant association with increased risk.', 'role': 'assistant'}]