This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunology and Rheumatology, Subject name: Medicine
[{'content': 'A 69-year-old man develops clubbing of his fingers. Which of the following is most likely associated with this condition? \nSelect and explain. \nA. RF, B. aortic stenosis, C. periosteal inflammation, D. crystal-induced arthritis', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Mononuclear cell infiltration and edema develop in the periosteum, synovial membrane, and joint capsule. Secondary hypertrophic osteoarthropathy (HOA) (e.g., lung cancer) is more common than primary HOA.', 'role': 'assistant'}]