This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemical Mediators and Regulators of Inflammation, Subject name: Pathology
[{'content': 'IL-1 is the principle chemical mediator of - \nSelect and explain. \nA. Fever, B. Itching, C. Vasoconstriction, D. Chemotaxis', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. is \'a\' i.e., Fever "IL-l and TNF-a are the two most important pyrogenes " -- Physiology basics.', 'role': 'assistant'}]