This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Paraganglioma seen in -a) Carotid body tumorb) Thoraxc) Para-vertebral locationd) Para-aortic lymph nodes \nSelect and explain. \nA. ab, B. bc, C. acd, D. abc', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Paraganglioma are clusters of neuroendocrine cells associated with the sympathetic and parasympathetic nervous system.\nParaganglioma is the tumor of neuroendocrine cells of these paraganglia that occurs at various body sites including head, neck, thorax and abdomen.\nMost common location of paragangliomas is adrenal medulla, where they are referred to as pheochromocytomas.\nOther locations are\n\n\nParavertebral ganglion (organs of zuckerkandl and rarely bladder)\nParaganglia related to the great vessels of head and neck, so called aorticopulmonary chain, including carotid bodies (most common); ganglion nodosum of vagus nerve; and clusters located about the oral cavity, nose nasopharynx, larynx, and orbit.\n\n\nMicroscopic features of Paraganglioma are:\n\n\nComposed of nests (zellballen) of round to oval chief cells (neuroectodermal origin) that are surrounded by delicate vascular septa.\nChief cells stain strongly for neuroendocrine markers such as chromogronin, synaptophysin, neuron specific enolase, CD56 and CD57.\nThere is a supporting stroma of spindle-shaped cells (sustentacular cells), that are positive for S-100 protein.\nNeuroendocrine granules', 'role': 'assistant'}]