This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Genetics, Subject name: Pathology
[{'content': 'Familial polyposis coli is associated with following genetic defect? \nSelect and explain. \nA. MLH1, B. MSH2, C. APC, D. RET', 'role': 'user'}, {'content': "Answer: C \nExplanation: Ans is ;c' i.e., APC * Familial adenomatous polyposis (FAP) syndrome (familial polyposis coli) is caused by mutation in adenomatous polyposis coli gene(APC) located on long arm of chromosome 5 (5q21). Risk of malignancy is 100%, i.e. all patients develop colorectal carcinoma if left untreated.", 'role': 'assistant'}]