This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Acute Inflammation - Overview and Morphologic Patterns, Subject name: Pathology
[{'content': 'Which of the following is responsible for respiratory burst and production of superoxide ions- \nSelect and explain. \nA. Hydrolase, B. Catalase, C. Peroxidase, D. NADPH oxidase', 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans. is 'D' i.e., NADPH oxidase o The final step in the microbial killing is due to reactive oxygen species called as respiratory burst. o Phagocytes require an enzyme to produce reactive oxygen species to destroy bacteria after they ingest the bacteria in a process called phagocytosis. o ROS are produced by the rapid assembly and activation of a multicomponent oxidase, NADPH oxidase and, in the process, reduces oxygen to superoxide anion (O2). o In neutrophils, this oxidative reaction is triggered by activating signals and accompanies phagocytosis and is called the respiratory burst.", 'role': 'assistant'}]