This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Which drug abolishes coicomedullary osmotic gradient ? \nSelect and explain. \nA. Furosemide, B. Thiazide, C. Spironolactone, D. Triamterene', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is'a'i.e., Furosemide (Ref. KDT p. 579)Furosemide (Frusemide)It is a high ceiling (loop) diuretic which inhibits of Na+-K+-2cl- cotranspoer.The coicomedullary osmotic gradient is abolished and positive as well as negative free water clearance is blocked.K+ excretion is increased mainly due to high Na+ load reaching DT.", 'role': 'assistant'}]