This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
[{'content': 'All of the following clinicopathologic features are seen more often in seminomas as compared to non-seminomatous germ cell tumors of the testis except: \nSelect and explain. \nA. Tumors remain localized to testis for a long time, B. They are radiosensitive, C. They metastasize predominantly by lymphatics, D. They are often associated with raised levels of serum AFP and HCG', 'role': 'user'}, {'content': 'Answer: D \nExplanation: "While hCG concentration may be inceased in patients with either nonseminoma or seminoma histology, the AFP concentration is increased only in patietns with nonseminoma." - Harrison\n\nSeminomas represent about 50% of all Germ cell tumors of testis.\nMedian age is 4th decade (Nonseminomas are most frequent in the 3rd decade).\n\nSeminomas follow a more indolent course.\n\nMost seminomas (70%) present with stage I disease (disease limited to testis),\nabout 20% with stage II disease (with retroperitoneal metastases),\nand 10% with stage III disease (spread beyond retroperitoneum)\n\n\n\nSeminomas as well as non-seminomas typically metastasize through lymphatics (except Choriocarcinoma which demonstrates early hematogenous spread)\nSeminomas are one of the most radiosensitive tumors (Non seminomas are insensitive to radiation).', 'role': 'assistant'}]