This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pediatrics, environment and nutrition, Subject name: Pathology
[{'content': "Anaplasia in Wilm's tumor is evident by- \nSelect and explain. \nA. Increased mitosis, B. Pleomorphic nuclei, C. Large nucleus, D. p53 mutation", 'role': 'user'}, {'content': 'Answer: B \nExplanation: ROBBINS BASIC PATHOLOGY. 10th edition. Chapter Genetic and Pediatric Diseases. Page no. 290. Approximately 5% of tumors contain foci of anaplasia (cells with large, hyperchromatic, pleomorphic nuclei and abnormal mitoses). The presence of anaplasia correlates with the presence of acquired TP53 mutations and the emergence of resistance to chemotherapy.', 'role': 'assistant'}]