This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology and breast, Subject name: Surgery
[{'content': 'The microscopic feature that differentiates a follicular carcinoma from a follicular adenoma is \nSelect and explain. \nA. Nuclear pleomorphism, B. Huhle cell change, C. Capsular invasion, D. Absence of colloid', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Follicular carcinoma can normally only be differentiated from follicular adenoma by the architecture of histology.Histologic diagnosis of FTC depends on the demonstration of follicular cells occupying abnormal positions, including capsular or vascular invasion. The cells may not demonstrate nuclear atypia; however, when present, marked nuclear atypia is associated with a worse prognosis.Ref: Sabiston 20e, page no: 927', 'role': 'assistant'}]