This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous (Gynae), Subject name: Gynaecology & Obstetrics
[{'content': 'Commonest cause of carcinoma endometrium is \nSelect and explain. \nA. Unopposed estrogen, B. Multiple sex partner, C. Early marriage, D. Early menarchae', 'role': 'user'}, {'content': 'Answer: A \nExplanation: (Unopposed estrogen) (392-S) (374-SI4th)Predisposing factors for carcinoma endometrium* Unsupervised administration of HRT with oestrogens alone during the menopause predisposes these women to develop endometrial hyperplasia and cancer* Women with oestrogen dominance suffering from endometrial hyperplasia and presenting as cases of DUB are prone to endometrial cancer* In some families there is a strong familial predisposition to the disease. This may be due to genetic factors or dietic habits* Tamoxifen prescribed to women with breast cancer are prone to develop endometrial hyperplasia / cancer* OCP have a protective effect. Also the practice of adding progestogens to oestrogen for HRT during the last 12 to 14 days of the cycle is protective against development of endometrial cancer* Obesity, Hypertension, DM are associated with endometrial cancer in 30% cases* Infertile women, those with fewer children and subjects of PCOD are prone to the disease', 'role': 'assistant'}]