This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cellular Pathology, Subject name: Pathology
[{'content': 'Which of the following is true about Nodular Regenerative Hyperplasia? \nSelect and explain. \nA. Nodule size 0.1 to 1 cm, B. Fibrosis septa present, C. Portal hypertension seen in 50% of patients, D. AST and ALT are markedly elevated', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ans: (c) Portal hypertension seen in 50% of patientsRef: Robbins Pathology, 9th editionFeatures of Nodular Regenerative Hyperplasia of LiverNodular hyperplasia diffusely affecting entire liver but with no / minimal fibrous septaDevelops at all ages but usually symptomatic at age 40+Associated with:Portal hypertensionConnective tissue disease (rheumatoid arthritis, polyarteritis nodosa)Myeloproliferative disordersLymphoproliferative disordersVascular disordersChemotherapyImmunosuppressive drugsAST - ALT mild elevation or normalPresents as non-cirrhotic portal hypertensionPathology (Gross and Microscopy)1-3 mm diameter nodulesNo fibrosis, only nodulesOn biopsy, apparent lack of central veins and presence of curvilinear areas of congestion are suggestiveReticulin stain highlights the fibrous nature', 'role': 'assistant'}]