This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Surgery
[{'content': 'Crohn&;s disease is associated with \nSelect and explain. \nA. NOD2\\/CARD15 gene, B. P53 supressor gene, C. Philadelpha chromosomes, D. BRACI gene', 'role': 'user'}, {'content': "Answer: A \nExplanation: .10% of first degree relatives; 50% of monozygotic twins develop Crohn's disease. Genes NOD2 / CARD15 in chromosome 16q12 has got strong association with Crohn's disease. CARD15 is expressed in Paneth cells of the ileum. * Smoking is related to Crohn's disease as aetiology, as for relapse and for exacerbations. There is increased mucus membrane permeability - antigen induced cell mediated inflammatory response - release of cytokines like TNF, interleukin 2 -m defect in suppressor T cell - granuloma and other pathology. ref:SRB&;s manual of surgery ,ed 3,pg no 801", 'role': 'assistant'}]