This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': "Crook's hyaline change occurs in - \nSelect and explain. \nA. Voluntary muscles, B. Diabetes mellitus liver, C. Basophils of pitutary gland in cushings disease, D. Viral hepatitis- B liver", 'role': 'user'}, {'content': 'Answer: C \nExplanation: The pituitary in Cushing syndrome shows changes regardless of the cause.The most common change is Crooke hyaline change -the normal granular, basophilic cytoplasm of ACTH producing cells is replaced by homogenous, lightly basophilic material. This alteration is the result of the accumulation of intermediated keratin filament in the cytoplasm.', 'role': 'assistant'}]