This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Virology, Subject name: Microbiology
[{'content': "All of the following are prion associated disease except: \nSelect and explain. \nA. Kuru, B. Creutzfeldt-Jacob disease, C. Alzheimer's disease, D. Scrapie", 'role': 'user'}, {'content': "Answer: C \nExplanation: Ans. C. Alzheimer's diseasePrionsa. Infectious proteins that cause CNs degenerationb. Prion diseases are disorder of protein conformationc. Reproduce by binding to normal, cellular isoforms of prion protein (PrPc) & stimulating conversion of (PrPc) into disease causing isoform (PrPSc)d. (PrPc )-rich in alpha helixe. (PrPSc )- rich in beta structure.f. Properties: - -devoid of NA- Infectious, genetic or sporadic- Disease result with accumulation of (PrPSc)* PrP gene- PRNP, located on chromosome 20* Most patients present with de mentia and myoclonus* Prion diseases:i. Kuruii. Familial fatal insomniaiii. Transmissible Mink Encephalopathyiv. Creutzfeldt- Jacob disease (CJD)v. Gerstmann- Straussler- Scheinker diseasevi. Scrapievii. Bovine Spongiform Encephalopathy", 'role': 'assistant'}]