This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Disorders of Adrenal Gland, Subject name: Medicine
[{'content': 'Pheochromocytoma is associated with: \nSelect and explain. \nA. Vitiligo, B. Cafe-au-lait spots, C. Ash leaf amelanotic macules, D. Acanthosis Nigricans', 'role': 'user'}, {'content': 'Answer: B \nExplanation: About 25-33% of patients with a Pheochromocytoma or paraganglioma have an inherited syndrome. Neurofibromatosis type 1 (NF 1) was the first described pheochromocytoma-associated syndrome. The NF1 gene functions as a tumor suppressor by regulating the Ras signaling cascade. Classic features of neurofibromatosis include multiple neurofibromas, cafe au lait spots, axillary freckling of the skin, and Lisch nodules of the iris. Pheochromocytomas occur in only about 1% of these patients and are located predominantly in the adrenals.', 'role': 'assistant'}]