This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti Microbial, Subject name: Pharmacology
[{'content': 'Most important side effect of Amphotericin B is \nSelect and explain. \nA. Fever and chills, B. Nephrotoxicity, C. Hyperkalemia, D. Anaemia', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e., Nephrotoxicity Important adverse effects of Amphotericin B:a) Acute reactions - occurs with each infusion and consists of chills, fever, aches and pain due to release of cytokines like TNF a, IL1 and IL6.b) Nephrotoxicity - It is the most important side effect which occurs uniformly and dose related and often manifests as azotemia, reduced GFR, acidosis, hypokalemia. It reverses slowly and often incompletely after stoppage of therapy.c) Anemia due to bone marrow depression which is largely reversible.d) CNS toxicity.", 'role': 'assistant'}]