This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Skin
[{'content': 'Spongiosis involves ? \nSelect and explain. \nA. Stratum basal, B. Stratum carneum, C. Stratum granulosum, D. Stratum spinosum', 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans. is 'd' i.e., Stratum spinosum Separation of keratinocytes due to loss of intracellular bridges --> Acantholysis Intracellular edema of keratinocytes ---> Ballooning Stratum basale Acantholytic cells of pemphigus vulgaris are derived from stratum basal. Basal cell degeneration occurs in Lichen planus. Stratum spinosum Intercellular (in between the cells) edema --> Spongiosis Thickening --> Acanthosis Stratum granulosum Thickening-Hypergranulosis Stratum corneum Retention of nuclei within cells Thickening Stratum corneum is involved in --> Parakeratosis --> Hyperkeratosis --> Micromunro abscess, Dermatophytes", 'role': 'assistant'}]