This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Pharmacology
[{'content': 'Non-competitive Inhibitors \nSelect and explain. \nA. Increase Km, B. Decrease Km, C. Increase Vmax, D. Decrease Vmax', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Lower V max But Do Not Affect Km', 'role': 'assistant'}]