This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Which of the following is associated with cystic disease in kidney? \nSelect and explain. \nA. Fibrocystin, B. Polycystin-1, C. Polycystin-2, D. All of the above', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Autosomal dominant polycystic kidney disease is caused by mutations in: The PKD1 gene encodes a large (460-kD) integral membrane protein named polycystin-1 The PKD2 gene product polycystin-2 Autosomal recessive kidney disease is caused due to mutation in PKHD1 gene coding for fibrocystin. Ref: Robbins 8th edition Chapter 20.', 'role': 'assistant'}]