This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Digitalis, Subject name: Pharmacology
[{'content': 'All are true statement about digitalis action EXCEPT: \nSelect and explain. \nA. Increases cardiac contraction, B. Pumps sodium out of cell, C. Increases intracellular calcium, D. Causes bradycardia', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Ans. (b) Pumps sodium out of cell* Digitalis is one of the cardiac glycosides which increases myocardial contractility and output in a hypodynamic heart without a proportionate increase in oxygen consumption.* Compounds in cardiac glycosides group include: digoxin, digitoxin, strophanthin, ouabain etc.* MOA of Digitalis: binds to Na+K+ATPase of myocardial fibres and inhibits this enzyme. This leads to progressive accumulation of Na+ intracellularly which indirectly results in intracellular Calcium accumulation.* ACTION:# Digitalis increases the force of contraction and decreases the heart rate# It also decreases the AV conduction, hence contraindication in WPW syndrome.# Causes diuresis in CHF patients# Causes decrease in peripheral resistance in CHF patients (because of withdrawal of reflex sympathetic overactivity)', 'role': 'assistant'}]