This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'A male patient 59 year old complains of multiple swellings in the neck, fever, and weight loss. He gives a history of hypertension treatment. General examination reveals painless lymph nodal enlargement in the neck and on blood investigation, anaemia is revealed. Lymph node biopsy shows typical owl eye-shaped appearance cells.\nWhat can be the most probable diagnosis for this patient? \nSelect and explain. \nA. Multiple myeloma, B. Hodgkin’s lymphoma, C. Non-hodgkin’s lymphoma, D. Burkitt’s lymphoma', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Hodgkin lymphoma, like NHL, usually manifests\xa0 as\xa0 painless\xa0 lymphadenopathy.\xa0 Although\xa0 a definitive\xa0 distinction\xa0 from\xa0 NHL\xa0 can\xa0 be\xa0 made\xa0 only\xa0 by examination\xa0 of\xa0 a\xa0 tissue\xa0 biopsy,\xa0 several\xa0 clinical\xa0 features favor\xa0 the\xa0 diagnosis\xa0 of\xa0 Hodgkin\xa0 lymphoma.\xa0 \xa0After the diagnosis is established, staging is used to guide therapy\xa0 and\xa0 determine\xa0 prognosis.\nYounger patients with more favorable subtypes tend to present with stage I or stage II disease and usually are free of so-called “B symptoms” (fever, weight loss, night sweats). Patients with advanced disease (stages III and IV) are more likely to\xa0 exhibit\xa0 B\xa0symptoms\xa0 as\xa0 well\xa0 as\xa0 pruritus\xa0 and\xa0 anemia.\nThe sine qua non of Hodgkin lymphoma is the Reed-Sternberg (RS) cell, a very large cell (15 to 45 µm in diameter) with an enormous multilobate nucleus, exceptionally prominent nucleoli, and abundant, usually slightly eosinophilic cytoplasm. Particularly characteristic are cells with two mirror-image\xa0 nuclei\xa0 or\xa0 nuclear\xa0 lobes,\xa0 each\xa0 containing\xa0 a\xa0 large (inclusion-like)\xa0 acidophilic\xa0 nucleolus\xa0 surrounded\xa0 by\xa0 a clear zone, features that impart an owl-eye appearance.\n\n\u200bDifference between Hodgkin Lymphoma and Non-Hodgkin Lymphoma', 'role': 'assistant'}]