This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Female is affected, the male is not. The disease is autosomal dominant, what is the chance in children? \nSelect and explain. \nA. 50% affected, B. 25% affected, C. 75% affected, D. All affected', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Autosomal dominant disorders are manifested in the heterozygous state.\nSo,\xa0at least one of the parent should be affected to transmit the disease to a child.\nThe homozygous state does not exist as it is not compatible with life, i.e. homozygous fetus usually dies in utero.\nSo, all the affected individuals will be heterozygous.\nIf an affected person marries an unaffected one, ie., if one of the parents is affected then every child has\xa050% of chance of having the disease and 50% of chance not having the disease.', 'role': 'assistant'}]