This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunology, Subject name: Microbiology
[{'content': 'An 11-year-old boy was brought to the pediatric OPD with multiple abscesses over his face, chest, and back. The child has a history of recurrentrespiratory infections. On examination, he has atopic excoriating skin and multiple cold abscesses on his back. What is the most probable diagnosis? \nSelect and explain. \nA. Hyper IgE syndrome, B. Hyper IgM syndrome, C. Carcinoid syndrome, D. Wiskott aldrich syndrome', 'role': 'user'}, {'content': "Answer: A \nExplanation: From the above clinical history and examination, the most probable diagnosis is Hyper IgE syndrome (Job's syndrome). It is an autosomal dominant primary immunodeficiency disease caused by a mutation of STAT3 gene. Neutrophils do not generate an immune response, probably due to a defect in chemotaxis. Patients present with recurrent staphylococcal skin abscesses, recurrent lung infections (pneumatoceles), eczema, eosinophilia and high serum levels of lgE. Reference: Ananthanarayan and Paniker&;s Textbook of Microbiology Tenth edition", 'role': 'assistant'}]