This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hemoglobinopathies: Sickle cell anemia, Subject name: Pathology
[{'content': 'Decreased osmotic fragility is not seen in which of the following conditions? \nSelect and explain. \nA. Thalassemia, B. Hereditary spherocytosis, C. Sickle cell anemia, D. Iron deficiency', 'role': 'user'}, {'content': 'Answer: B \nExplanation: - Hereditary spherocytosis is associated with increased osmotic fragility because RBCs are spherical & unstable d/t defect in their cytoskeleton. Osmotic fragility curves of normal and hereditary spherocytosis red blood cells.', 'role': 'assistant'}]