This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Lymphoma and Plasma cell disorder, Subject name: Medicine
[{'content': "Popcorn variant of Reed-Sternberg cell is seen in? \nSelect and explain. \nA. Follicular center lymphoma, B. Lymphocyte depleted Hodgkin's disease, C. Nodular sclerosis Hodgkin's disease, D. Lymphocyte predominant Hodgkin's disease", 'role': 'user'}, {'content': 'Answer: D \nExplanation: Popcorn variant of Reed-Sternberg cell is seen in lymphocyte predominant Hodgkin\'s disease Variants of Reed -Sternberg Cells Subtypes of Hodgkin\'s Associated Mononuclear variant = Variant of R.S. cell, mononucleated. Mixed cellularity Lacunar Variant = Large cells with hyperlobated nucleus, multiple small nuclei and eosinophilic cytoplasm around the nucleus creating an empty space called lacunae Nodular sclerosis Lympho-histiocytic variant (popcorn cell variant) = Cell with multiple folded or convoluted nuclear contour resembling a "popcorn kernel" Lymphocytic predominant Note MC subtype of Hodgkin lymphoma : Nodular sclerosis ( Globally ) Mixed cellularity ( In India )', 'role': 'assistant'}]