This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'Which of the following syndromes is best associated with congenital heart disease – \nSelect and explain. \nA. Lesch–Nyhan syndrome, B. Rasumussen syndrome, C. Holt Oram syndrome, D. LEOPARD syndrome', 'role': 'user'}, {'content': 'Answer: C \nExplanation: "The strongest familial tendency is known in ASD associated with bony abnormalities (Holt-oram syndrome)"\nGenetics of Congenital heart disease', 'role': 'assistant'}]