This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: vitamins, Subject name: Biochemistry
[{'content': 'Which is not Pyridoxine-dependent? \nSelect and explain. \nA. Oxaluria, B. Homocystinurea, C. Maple syrup urine disease, D. Xanthenuric aciduria', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Deficiency of Vitamin B6 (Pyridoxine) leads to:- Peripheral neuropathy Convulsions: Due to decreased synthesis of GABA Microcytic hypochromic Anemia: Due to decreased heme synthesis Pellagra due to defective niacin synthesis Oxaluria: Due to defective Alanine: Glyoxylate Amino Transferase. Glyoxylate conveed to Oxalic acid Homocystinuria: Due to defective Cystathionine Beta-Synthase Xanthurenic Aciduria: Due to defective Kynureninase Cardiovascular risks: Because of homocysteinemia Maple syrup urine disease is the defect of deficient decarboxylation of branched-chain keto acids. Decarboxylation of the BKA requires thiamine. Reference: DM.VASUDEVAN.TEXTBOOK 8th EDITION page no ;472', 'role': 'assistant'}]