This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Blood, Subject name: Pathology
[{'content': 'A 25-year-old woman with a history of systemic lupus erythematosus presents with diffuse petechiae and fatigue. Physical examination demonstrates lymphadenopathy and splenomegaly Laboratory findings include normocytic anemia (hemoglobin =6.1 g/dL) and thrombocytopenia (30,000/mL). Which of the following is the most likely underlying mechanism in the development of thrombocytopenia in this patient? \nSelect and explain. \nA. Antibody-mediated platelet destruction, B. Clonal plasma cell circulating paraprotein, C. Decreased susceptibility to complement-mediated lysis, D. Defect in the platelet cytoskeleton', 'role': 'user'}, {'content': 'Answer: A \nExplanation: In common with idiopathic thrombocytopenic purpura and certain drug-induced thrombocytopenias, systemic lupus erythematosus is associated with increased platelet destruction due to immune-mediated damage and removal of circulating platelets (antibody-mediated platelet destruction). The other choices do not represent immune destruction of platelets.Diagnosis: Idiopathic thrombocytopenic purpura, systemiclupus erythematosus', 'role': 'assistant'}]