This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Growth and development, Subject name: Pediatrics
[{'content': 'The most common cardiovascular lesion in Down&;s syndrome is: \nSelect and explain. \nA. VSD, B. Endocardial cushion defect, C. TOF, D. COA', 'role': 'user'}, {'content': 'Answer: B \nExplanation: The most common cardiovascular lesion in Down&;s syndrome is endocardial cushion defect. Other associated defects are atrial septum defects(ASD), ventricular septum defect(VSD), and patent ductus aeriosus(PDA), aberrant subclan aery, and pulmonary hypeension. Clinical Features: Intellectual disability/Incurved or sho fifth finger with clinodactyly Congenital hea disease Acute megakaryoblastic leukemia/Alzheimer&;s disease/Atlantoaxial instability/Atresia of the duodenum Protruding tongue Round face Occiput flat/Open wide fontanelle/Open mouth Brachycephalic/Brushfiel&;s spots Low (depressed) nasal bridge Epicanthal fold/Ears low set and dysplastic Mongoloid slant (Oblique palpebral fissure) Simian palmar crease and wider gap between first and second toes. Ref: Nelson textbook of pediatrics 21st edition Pgno: 660', 'role': 'assistant'}]