This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cardiovascular system, Subject name: Pathology
[{'content': 'Earliest histological change in MI- \nSelect and explain. \nA. Macrophage infiltration, B. Neutrophilic Infiltration, C. Waviness of fibers, D. Coagulative necrosis', 'role': 'user'}, {'content': 'Answer: C \nExplanation: The microscopic appearance also undergoes a characteristic sequence of changes Typical features of coagulative necrosis become detectable within 4 to 12 hours of infarction. "Wavy fibers" also can be present at the edges of an infarct; these reflect the stretching and buckling of noncontractile dead fibers. Sublethal ischemia can also induce intracellular myocyte vacuolization; such myocytes are ble but frequently are poorly contractile. (Robbins Basic Pathology,9th edition,pg no.383)', 'role': 'assistant'}]