This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Biosynthesis of Fatty Acids and Eicosanoids, Subject name: Biochemistry
[{'content': 'Catabolism of long chain fatty acids occur in: \nSelect and explain. \nA. Mitochondria, B. Peroxisome, C. Endolysosome, D. Golgi bodies', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans: A (Mitochondria) Ref: Lippincott Illustrated Biochemlstryt 6th edition, chapter 16, pg 190Explanation:Mechanism of catabolismChieforganelleFatty acidsBeta oxidationMitochondria* Long chain fatty acids* Medium chain fatty acids* Short chain fatty acidsBeta oxidationPeroxisomes* Very long chain fatty acidsOmegaoxidationEndoplasmicreticulum* Works only when mitochondria does not oxidizeAlpha oxidationPeroxisomes* Branched chain fatty acidsAlso Remember:Alpha-Oxidation occurs in Peroxisomes and is used for branched fatty acids that cannot directly undergo |3-oxidation such as phytanic acid.Omega-oxidation occurs in smooth ER of the liver and is primarily used for detoxification but can become more active if mitochondrial |3-oxidation is defective.Beta oxidation of very long chain [20 or more carbons) fatty acids occur in peroxisome.VLCFA should be first broken down to a manageable size in peroxisome before it can be oxidized in mitochondria.', 'role': 'assistant'}]