This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'The gene involved in GIST - \nSelect and explain. \nA. C-KIT, B. BRAC-1, C. p53, D. BRAC-2', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., C-KIT Pathogenesis of GISTs o Approximately 75% to 80% of all GISTs have oncogenic, gain-of-function mutations of gene encoding the tyrosine kinase c-KIT o Approximately 8% of GISTs have mutations that activate a related tyrosine kinase, platelet derived growth factor receptor a (PDGFRA). o Consitutively active c-KIT or PDGFRA receptor tyrosine kinases activate RAS and P13K/AKT pathways and thereby promote tumor cell proliferation.", 'role': 'assistant'}]