This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Genetic Basics Of Carcinogenesis, Subject name: Pathology
[{'content': 'A 15 year old boy presents was brought to OPD with a history of pain and swelling in the right thigh. Biopsy of the mass demonstrates Osteosarcoma. His mother was diagnosed with breast cancer 1 year ago and his maternal grandmother died of the breast cancer 10 years ago. The child has 3 younger siblings. Siblings are at an increased risk of developing which of the following cancer ? \nSelect and explain. \nA. Wilms, B. Neuroblastoma, C. Hepatoblastoma, D. Glioma', 'role': 'user'}, {'content': 'Answer: D \nExplanation: This is a likely the case of Li Fraumeni syndrome. Li Fraumeni syndrome Cancer predisposition syndrome before the age of 45 years Associated with high risks for a diverse spectrum of childhood- and adult-onset malignancies due to germline p53 gene mutation as per Chompret criteria. 5 cancer types are : Adrenocoical carcinomas, Breast cancer, Central nervous system tumors, Osteosarcomas, Soft-tissue sarcomas. Out of the given options central nervous system tumor is glioma', 'role': 'assistant'}]