This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
[{'content': 'Chloroquine is given as 600 mg loading dose because: \nSelect and explain. \nA. It is rapidly absoed, B. It is rapidly metabolized, C. It has increased tissue binding, D. It is rapidly eliminated', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Oral absorption of CQ is excellent. About 50% gets bound in the plasma. It has high affinity for melanin and nuclear chromatin: gets tightly bound to these tissue constituents and is concentrated in liver, spleen, kidney, lungs (several hundred-fold), skin, leucocytes and some other tissues. Its selective accumulation in retina is responsible for the ocular toxicity seen with prolonged use. ESSENTIALS OF PHARMAXOLOGY page no.822', 'role': 'assistant'}]