This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Neoplastic Agents, Subject name: Pharmacology
[{'content': 'Ifosfamide belongs to which group of anticancer drugs- \nSelect and explain. \nA. Alkylating agents, B. Antiimetobolites, C. Mitotic inhibitors, D. Topoisomerase inhibitors', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Alkylating agents Ifosfamide belongs to alkylating agentIt is an analogue of cyclophosphamide.It is used in combination for germ cell testicular cancer and is widely used to treat pediatric and adult sarcomas. Adverse effect of If sodamide:-Ifosfamide has virtually the same toxicity profile as cyclophosphamide although it causes greater platelet suppression, neurotoxicity, nephrotoxicity and in the absence of mesna, urothelial damage.When it is used in high doses (myeloablative doses) it causes severe neurological toxicity.When it is used in non myeloablative or low doses it causes severe urinary tract abnormalities. Intravenous mesna is given together with ifosfamide to prevent urinary tract adverse effects.", 'role': 'assistant'}]