This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.N.S, Subject name: Medicine
[{'content': 'Contraindication for PA in ischemic stroke is \nSelect and explain. \nA. Clinical diagnosis of stroke, B. Systolic BP < 180 mm of Hg, C. Comatose patient, D. Onset of symptoms < 4.5 hours', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Contraindications for administration of Intravenous Recombinant Tissue Plasminogen Activator (PA ) for Acute Ischemic Stroke (AIS)Sustained BP >185/110 mmHg despite treatmentPlatelets <100,000; HCT <25%; glucose <50 or >400 mg/dLUse of heparin within 48 h and prolonged PTT, or elevated INRRapidly improving symptomsPrior stroke or head injury within3 months; prior intracranial haemorrhageMajor surgery in preceding 14 daysMinor stroke symptomsGastrointestinal bleeding in preceding21 daysRecent myocardial infarctionComa or stuporRef: Harrison 19e pg: 2562', 'role': 'assistant'}]