This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': 'A 35-year-old male patient presented with a history of jaundice for 15 days. The onset was preceded by a prodromal illness. His serum tested positive for HBsAg. A clinical diagnosis of acute Hepatitis B was made. What should be the next best confirmatory investigation - \nSelect and explain. \nA. Antii-HBeAg antibody, B. HBe antigen, C. Anti-HBe IgM antibody, D. HBV DNA by PCR', 'role': 'user'}, {'content': 'Answer: A \nExplanation: None', 'role': 'assistant'}]