This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cellular Pathology, Subject name: Pathology
[{'content': 'Pro-apoptotic gene and anti-apoptotic gene belong to which gene family? \nSelect and explain. \nA. p53, B. Bcl, C. BRAF, D. Rb', 'role': 'user'}, {'content': 'Answer: B \nExplanation: * The major mechanism of intrinsic mitochondrial pathway of apoptosis is by pro- and anti-apoptotic members of bcl proteins.* Bcl protein was first detected on B cell lymphoma and hence its name.* It is located on mitochondrial inner membrane and regulates cell growth and cell death.* Pro-apoptotic mechanisms can damage mitochondrial membranes and allow leakage of cytochrome C into the cytoplasm. Cytochrome C is the lifeline of intact mitochondria.Growth promoter/anti-apoptotic proteinsPro-apoptotic proteinsBcl-2, Bcl-X and Mcl-1Bim, Bad and Bid', 'role': 'assistant'}]