This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': "Wilm's tumor is associated with all the following except : \nSelect and explain. \nA. Aniridia, B. Beckwith syndrome, C. Polycystic kidney, D. Hemi – hypertrohy", 'role': 'user'}, {'content': "Answer: C \nExplanation: Warn' s tamer :\n\nWilm's tumor, also known as nephroblastoma, is the most common malignant tumor of kidney in children. Etiology.\nMost of the tumor are sporadic.\n1- 2% may have family history.\nFamilial predisposition to wilm's tumor is inherited in an autosornal dominant manner.\nMutation of the following genes are seen in wilms tumor.\n\n\nWilms tumor gene (WT 1) on chromosome 11.\nCTNNB I gene encoding the protooncogene beta - ca ten in.\np53.\n\nWilm's tumor is associated with three distinct syndromes.\n\n\n\nWAGR syndrome\nBeck with Wiedemnn syndrome\nDenys - Drash syndrome\n\n\n\n\nWilm's tumor\nAniridia\nGenital abnormalities\nMental Retardation\n\n\n\n\nEnlargement of body organs\nHemihypertrophy\nRenal medullary cysts\nAdrenal cytomegaly : abnormal large cells in adrenal cortex\n\n\n\n\nGonadal dysgenesis (Male pseudo - hermaphrodite)\nNephropathy leading to Renal failure", 'role': 'assistant'}]