This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Most impoant change to occur in irreversible cell injury - \nSelect and explain. \nA. Decreased basophillia, B. Pyknosis, C. Accumulation of myelin figures, D. Membrane damage', 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans is 'd' i.e. Membrane damage Membrane damage is the central pathogenic process in irreversible injury.", 'role': 'assistant'}]