This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Paediatrics, Subject name: Pediatrics
[{'content': 'A 3 year old girl is found to have recurrent fractures after tril trauma. On taking a detailed history, several other family members were found to be affected by similar complaints. So, a pedigree cha was drawn, which is shown below. Which of the following is the mode of inheritance of this disorder? \nSelect and explain. \nA. Autosomal dominant disorder, B. Autosomal recessive disorder, C. X linked recessive disorder, D. X linked dominant disorder', 'role': 'user'}, {'content': "Answer: A \nExplanation: 3 Golden rules of Pedigree Analysis are: If all children of an affected female have the disease - Mitochondrial inheritance If at least 1 of the parent is affected by disease - Dominant Inheritance Father to Son transmission - Rules out X- linked disease In the given pedigree, As all affected individuals have one parent affected, it is 'Dominant' inheritance. As there is a father-to-son transmission, it cannot be X-linked inheritance. So, the given pedigree shows 'Autosomal dominant' inheritance.", 'role': 'assistant'}]