This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
[{'content': 'Which of the following mutations in a tumour suppressor agent causes breast carcinoma- \nSelect and explain. \nA. p43, B. p53, C. p73, D. p83', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Robbins and Cotran pathologic basis of disease South Asia edition. Breast cancer may be hereditary arising in women with germline mutation in tumour suppressor gene or sporadic. after a cell sustains DNA damage it must undergo cell cycle arrest and either repair its DNA or for by apoptosis by P53 . In its mutated form P53 ceases to act as a protector or as growth suppressor but instead acts like a growth promoter or onco gene..', 'role': 'assistant'}]