This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'Earliest symptom of Tay sach disease \nSelect and explain. \nA. Exaggerated stale response, B. Bone deformation, C. Hepatomegaly, D. Excessive bleeding', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Exaggerated stale response Tay-Sach diseaseClinical symptoms are usually evident in the first year of lifeInitial signs are not dramatic and present as enfeeblement, spasticity and slow development.An exaggerated stale response to sound may be the most significant early sign of which a parent is aware.Other features are mental retardation, deterioration of vision and early death.", 'role': 'assistant'}]