This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Medicine
[{'content': 'In multiple myeloma following are seen -( \nSelect and explain. \nA. Increase Calcium, B. Bone pain, C. Renal failure, D. All of the above', 'role': 'user'}, {'content': 'Answer: A \nExplanation: In multiple myeloma ,hypercalcemia occurs due to destruction of bone. Bone pain is the most common symptom.The pain usually involves the back & ribs. Pathological fracture may occur causing localised pain.Bone pain results from the proliferation of tumour cells in the marrow & activation of osteoclasts which destroy the bone. Renal failure occurs due to hypercalcaemia, glomerular deposits of amyloid,hyperuricaemia, & infiltration of kidney by myeloma cells.Reference:Harsh mohan textbook of pathology sixth edition pg no 383.', 'role': 'assistant'}]