This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Enzymes, Subject name: Biochemistry
[{'content': 'Aspirin irreversibly inhibits the following enzyme in the formation of eicosanoids: \nSelect and explain. \nA. Lipoxygenase, B. Cyclooxygenase, C. Phospholipase-A2, D. Peroxidase', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Ans. B. CyclooxygenaseCyclooxygenase is required for the synthesis of prostaglandins by arachidonic acid. Aspirin, indomethacin, brufen, phenyl butazone and other NSAIDS inhibits COX (Cyclooxygenase). Aspirin inhibits COX of both PGHS-1 and PGHS-2 by acetylation', 'role': 'assistant'}]