This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
[{'content': 'The commonest mode of inheritance of congenital hea disease is \nSelect and explain. \nA. Autosomal dominant, B. Autosomal recessive, C. Sexlinked dominant, D. Multifactorial', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ref Harrison 19 th ed pg 1516 The most common bih defects are cardiovascular in origin. These malformations are due to complex multifactorial genetic and environ- mental causes. Recognized chromosomal aberrations and mutations of single genes account for <10% of all cardiac malformations. Congenital hea disease (CHD) complicates ~1% of all live bihs in the general population--about 40,000 bihs/year--but occurs more frequently in the offspring (about 4-10%, depending on maternal CHD type) of women with CHD. Owing to the remarkable surgical advances over the last 60 years, >90% of afflicted neonates and children now reach adulthood; women with CHD may now frequently successfully bear children after competent repairs.', 'role': 'assistant'}]