This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General obstetrics, Subject name: Gynaecology & Obstetrics
[{'content': 'Minimum amount of folic acid supplementation a woman should take preconceptionally is \nSelect and explain. \nA. 10 micrograms, B. 40 micrograms, C. 100 micrograms, D. 400 micrograms', 'role': 'user'}, {'content': "Answer: D \nExplanation: The incidence of neural-tube defects (NTDs) is 0.9 per 1000 live bihs, and they are second only to cardiac anomalies as the most frequent structural fetal malformationIt is currently recommended, that all women who may become pregnant take daily 400mg of folic acid orally before conception and through the first trimesterReference: William's obstetrics; 25th edition; Chapter 8; Preconceptional care", 'role': 'assistant'}]