This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
[{'content': 'Which of the following drugs produce significant nephrotoxicity? \nSelect and explain. \nA. Cisplatin, B. Carboplatin, C. Vinblastine, D. Vincristine', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Carboplatin It is a less reactive second generation platinum compound that is better tolerated and has a toxicity profile different from cisplatin. Nephrotoxicity, ototoxicity and neurotoxicity are low. Nausea and vomiting is milder and is delayed: only infrequently limits the dose. The dose-limiting toxicity is thrombocytopenia and less often leucopenia. Because of less plasma protein binding, it is rapidly eliminated by the kidney (half life 4-6 hr). It is primarily indicated in ovarian carcinoma of epithelial origin, and has shown promise in squamous carcinoma of head and neck, small cell lung cancer and seminoma. ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SIXTH EDITION PAGE NO:828', 'role': 'assistant'}]