This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Diabetes, Subject name: Biochemistry
[{'content': 'The activity of which of the following enzymes is increased in Diabetes Mellitus? \nSelect and explain. \nA. CPT-1, B. Phosphoenol Pyruvate carboxykinase (PEPCK), C. Glucose-6-Phosphatase, D. All', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Diabetic situation is same like fasting or starvation i.e. catabolic situation in the body. So, in Diabetes Mellitus, the activity of Catabolic enzymes is increased. Carnitine Palmitoyl Transferase-I (CPT-I) is an enzyme of b-Oxidation which is a Catabolic pathway. Therefore, it is increased in Diabetes. Option b & c - Phosphoenol Pyruvate Carboxykinase (PEPCK) and Glucose -6-Phosphatase are enzymes of Gluconeogenesis which is a Catabolic pathway and hence increased in Diabetes. So, answer is all.', 'role': 'assistant'}]