This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous (Bio-Chemistry), Subject name: Biochemistry
[{'content': 'NADPH oxidase deficiency causes: \nSelect and explain. \nA. Chedickhigasi syndrome, B. Chronic granulomatous disease, C. Leucocyte adhesion defect type 1, D. Leucocyte adhesion defect type 2', 'role': 'user'}, {'content': 'Answer: B \nExplanation: ANSWER: (B) Chronic granulomatous diseaseREF: Medical biochemistry at a glance J. G. Salway page 47, The Metabolic basis of inherited disease John Bruton Stanbury page 1971Chronic granulomatous disease is a rare, X-linked deficiency of NADPH oxidase activity which drastically impairs the ability of macrophages and neutrophils to destroy pathogens. Patients are especially vulnerable to mycobacteria, E coli, and staphylococcus since these organisms produces catalase to defend themselves against hydrogen peroxide attack by phagocytes.', 'role': 'assistant'}]