This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Disorders of Amino acid Metabolism, Subject name: Pediatrics
[{'content': 'A 6-month-baby presented with recurrent seizures and developmental delay. On examination there was alopecia and scaly skin rashes. Investigations revealed metabolic acidosis, elevated lactates & ketonuria. What could be the underlying enzyme deficiency? \nSelect and explain. \nA. Phenylalanine hydroxylase, B. Epimerase, C. Multiple carboxylase, D. Glucose 6 phosphatase', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Skin rashes with presence of ketones and metabolic acidosis are all features of Multiple carboxylase deficiency. Phenylalanine hydroxylase deficiency- microcephaly, hypopigmentation, musty body odour Glucose 6 phosphatase deficiency- doll like facies', 'role': 'assistant'}]