This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Osteogenesis imperfect defect in - \nSelect and explain. \nA. Collagen type I, B. Elastin, C. Collagen type IV, D. basement membrane', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. is \'a\' i.e., Collagen type I o Osteogenesis imperfecta also known as brittle bone disease, or "Lobstein syndrome" is a congenital bone disorder. o People with 01 are born with defective connective tissue, or without the ability to make it, usually because of a deficiency of Type-I collagen. o This deficiency arises from an amino acid substitution of glycine to bulkier amino acids in the collagen triple helix structure.', 'role': 'assistant'}]