This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Pathology
[{'content': 'Which of the following zone of the liver lobule is more prone to ischemia? \nSelect and explain. \nA. Peripoal, B. Midzonal parenchyma, C. Centrilobular zone, D. All zones are affected equally', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Centrilobular zone (zone 3) is zone with poor oxygenation , therefore is more prone to ischemia * Liver is divided histologically into lobules. * The center of the lobule is the central vein. * At the periphery of the lobule are poal triads. * Based on the oxygen supply , the liver can be divided into three zones. Zone 1 : Peripoal zone - encircles the poal tracts where the oxygenated blood from hepatic aeries enters. Zone 2 : Midzonal parencyma - is located in between. Zone 3 : Centrilobular Zone - is located around central veins, where oxygenation is poor.', 'role': 'assistant'}]