This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
[{'content': 'Peau d’orange appearance is due to - \nSelect and explain. \nA. Intra-epithelial cancer, B. Sub-epidermal cancer, C. Lymphatic permeation, D. Vascular embolization', 'role': 'user'}, {'content': "Answer: C \nExplanation: Phenomena resulting from lymphatic obstruction in advanced breast cancer\n1. Peaud* orange \xa0Peau d' orange is due to cutaneous lymphatic edema, where the infiltrated skin is tethered by the sweat ducts, it cannot swell, leading to an appearance like orange skin. Occasionally it may be seen in a chronic abscess.\xa0\n2. Cancer-en-cuirasse Is infiltration of the skin with carcinoma\n3. Lymphangiosarcoma \xa0It’s a rare complication of lymphodema with an onset many years following the treatment.\nIt takes the form of multiple subcutaneous nodules in the upper limb and must be distinguished from recurrent carcinoma of the breast.", 'role': 'assistant'}]