This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Medicine
[{'content': 'A 37-year-old immunosuppressed patient with renal failure develops sepsis. Which of the following antibiotics, if used, would require a major reduction in dosage? \nSelect and explain. \nA. erythromycin, B. doxycycline, C. tobramycin, D. isoniazid (INH)', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Amikacin and vancomycin are the other antibiotics that require dose reduction in renal failure. Newer antibiotics are often used instead of aminoglycosides to reduce the risk of renal damage.', 'role': 'assistant'}]