This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Adverse Drug Effect, Subject name: Pharmacology
[{'content': 'Cholelithiasis and choledocholithiasis is caused by? \nSelect and explain. \nA. Clofibrate, B. Chloramphenicol, C. Cotrimaxozole, D. NS AIDS', 'role': 'user'}, {'content': "Answer: A \nExplanation: ANSWER: (A) ClofibrateREF: Robbin's 8th ed CH: 8Drugs causing cholelithiasis and choledocholithiasis:Clofibrates: Clofibrate, used to lower blood cholesterol, increases hepatic HMG-CoA reductase and decreases conversion of cholesterol to bile acids by reducing cholesterol 7-a-hydroxylase activity. The net result of these influences is excess biliary secretion of cholesterolEstrogen and OOP'SSomatostatin analogues appear to predispose to gallstones by decreasing gallbladder emptying.Ampicillin", 'role': 'assistant'}]