This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Detoxication of drugs is controlled by \nSelect and explain. \nA. Cytochrome, B. Cytochrome p450, C. Cytochrome, D. Cytochrome A', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Cytochrome p450 enzymes are microsomal enzymes that are involved in phase I metabolism of many drugs,\nMost of the drugs are metabolized by CYP 3 A4 isoform. Drug metabolizing enzymes The drug-metabolizing enzymes are divided into two types :\n1. Microsomal These are located on smooth endoplasmic reticulum primarily in the liver, also in kidney, intestinal mucosa and lungs.\nExamples are monooxygenase, cytochrome P450, glucuronyl transferase.\nThey catalyze most of the oxidation, reduction, hydrolysis and glucuronide conjugation.\nThey are inducible by drugs, diet and other agencies.\n2. Nonmicrosomal These are present in the cytoplasm and mitochondria of hepatic cells as well as in other tissues including plasma.\nExamples are flavoprotein oxidase, esterases, amidases and conjugases.\nThey catalyze some oxidation and reduction, many hydrolysis and all conjugation except glucuronidation.\nThey are not inducible but many show genetic polymorphism (acetyltransferase, pseudocholinesterase)', 'role': 'assistant'}]