This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': "In hashimoto's disease serum antibodies are mainly against -a)  Thyroid folliclesb)  Thyroxinec)  Thyroglobulinsd)  Iodine \nSelect and explain. \nA. a, B. bc, C. ac, D. b", 'role': 'user'}, {'content': "Answer: C \nExplanation: Hashimotos Thyroiditis -\n\nHashimoto's thyroiditis is an autoimmune disorder\nIt is the most common cause of primary hypothyroidism\nIt mainly affects middle aged females\nAlthough it is primarily a disease of the middle aged females, it can occur in children and is a major cause of\xa0nonendemic goitre in children.\nPathogenesis -\nHashimoto's thyroiditis is an autoimmune disorder characterized by the presence of following IgG antibodies -\n\n\nAntithyro globulin antibody\xa0\xa0\xa0\nAntimicrosomal antibody\xa0\nAntibody directed against a component of colloid\nAntibody against TSH receptors\n\n\nThese antibodies do not correlate with severity of disease.\n\nThey have a diagnostic value", 'role': 'assistant'}]