This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'All of the following are vitamin K dependent coagulation factors except: \nSelect and explain. \nA. Factor X, B. Factor VII, C. Factor II, D. Factor VIII', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Clotting factors II, VII, IX and X are vitamin K dependent factors.\nSix of the proteins involved in clotting require conversion of a number of glutamic acid residues to\xa0γ-carboxyglutamic acid residues before being released into the circulation, and hence all six are vitamin K-dependent. These proteins are factors II (prothrombin), VII, IX, and X, protein C\xa0and protein S.\nCoumarin derivatives such as dicumarol and warfarin are also effective anticoagulants. They inhibit the action of vitamin K, which is a necessary cofactor for the enzyme that catalyzes the conversion of glutamic acid residues to γ-carboxyglutamic acid residues.\xa0\nReference: Ganong’s Review of Medical Physiology TWENTY - FIFTH\xa0 EDITION page no 566,567', 'role': 'assistant'}]