This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'The most appropriate management for maintaining patency of ductus arteriosus in a neonate is – \nSelect and explain. \nA. Prostaglandin E1, B. Oxygen, C. Nitric oxide, D. Indomethacin', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ductus arteriosus remains patent in the uterus in the fetal life because of high level of vasodilators especially prostaglandin E2 in the blood.\nAfter birth the prostaglandin synthesis is inhibited by inhibition of cycloxygenase at birth.\nSo if the patency of ductus arteriosus has to be maintained → prostaglandins should be given.\nThe drug which is specifically used for this is prostaglandin E1 (Misoprost, Rioprostil)\nIf the ductus arteriousus has to be closed, prostaglandin synthesis inhibitor - Indomethacin should be given.', 'role': 'assistant'}]