This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Histology of Alport syndrome -a) Foamy cells in interstitiumb) Foamy cells in tubular epithelial cellsc) Thickening of GBM > 100 nmd) Thinning of GBM < 100 nme) Intimal proliferation \nSelect and explain. \nA. b, B. c, C. ad, D. ab', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Histological characteristics of Alport’s syndrome:\n• Diffuse basement membrane thinning\xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0\xa0• Vascular sclerosis\n• Foam cells in interstitium\xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0\xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 • Tubular atrophy\n• In advanced stage there is focal or global glomerulosclerosis\xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0\xa0• Interstitial fibrosis\nOn electron microscopy (diagnostic of this disorder), GBM shows\n• Irregular foci of thickening alternating with thinning\n• Pronounced splitting and lamination of lamina densa (basket weave appearance).\n• Info: Immunohistochemistry shows failure to stain a-3, 4, 5 collagen.', 'role': 'assistant'}]