This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Pathology
[{'content': 'Which of the following antibodies is most frequently seen in Antiphospholipid Syndrome ? - \nSelect and explain. \nA. Beta 2 microglobulin antibody, B. Anti-nuclear antibody, C. Anti-centromere antibody, D. Anti- beta 2 glycoprotein antibody', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Antiphospholipid antibody syndrome has clinical manifestations including recurrent thrombosis, repeated miscarriages, cardiac valve vegetations and thrombocytopenia. Suspected Ab target include Beta 2 Glycoprotein 1, a plasma protein that associates with the surfaces of endothelial cells and trophoblasts. Anti nuclear antibody and beta 2microglobulin Ab seen in SLE. Reference : Robbins and Cotran Pathologic basis of disease.South Asia Edition -9;volume 1.page no. 124', 'role': 'assistant'}]