This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Which virus is implicated in Burkitts lymphoma? \nSelect and explain. \nA. HTLV, B. HPV, C. EBV, D. HHV8', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Explanation: BURKITT LYMPHOMA There are three clinical types:\n1. African (endemic) Burkitt lymphoma.\n2. Sporadic (nonendemic) Burkitt lymphoma.\n3. Aggressive lymphomas associated with HIV.\nThese 3 types are histologically identical. Morphology The tumor exhibits a high mitotic index and contains numerous apoptotic cells,\nthe nuclear remnants of which are phagocytosed by interspersed benign macrophages.\nThese phagocytes have abundant clear cytoplasm, creating a characteristic “starry sky” pattern. Immunophenotype These are tumors of mature B cells.\nIt express surface IgM, CD 19, CD20, CD 10 and BCL6. a phenotype consistent with a germinal center B-cell origin.\nUnlike other tumors of germinal center origin, this does not express anti-apoptotic protein BCL2.\nMolecular Pathogenesis All forms of Burkin lymphoma are associated with translocations of the c-MYC gene on chromosome 8.\nThe translocation partner is usually the IgH locus  light-chain loci.\nAll endemic tumors are latently infected with EBV. which is also present in about 25% of HIVassociated tumors and 15% to 20% of sporadic cases.\nClinical Features Endemic Burkitt lymphoma often presents as a mass involving the mandible and shows an unusual predilection for involvement of abdominal viscera,\nparticularly the kidneys, ovaries and adrenal glands. Sporadic Burkitt lymphoma most often appears as a mass involving the ileocecum and peritoneum.\nBurkitt lymphoma is very aggressive but responds well to intensive chemotherapy', 'role': 'assistant'}]