This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Malarial, Subject name: Pharmacology
[{'content': "Even in large dosages used in malaria, quinine does not cause toxicity, because : \nSelect and explain. \nA. It enters in fat cells, B. Elevated plasma alpha acid glycoprotein, C. Deposited in infected RBC's, D. Excreted rapidly in urine", 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' elevated plasma alpha} acid glycoprotein. Patient with malaria can achieve high plasma level of quinine with few signs of toxicity because of the elevated plasma alpha 1 acid glycoproteins, produced during acute phase of infection. It prevents quinine toxicity through binding of most of the drug in the plasma.Peak plasma level which a person can achieve without producing toxicity.a. in severely ill patients -15-20 mg/litreb. in persons without malaria - 10 mg/litreAbout quinineIt is an erythrocytic schizonticide*Used for treatment of multidrug resistant strains of P. falciparumAssociated with a triad of dose related toxicitiesCinchonism*Hypotension*Hypoglycemia*", 'role': 'assistant'}]