This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Gynaecological oncology, Subject name: Gynaecology & Obstetrics
[{'content': "Increased risk of endometrial and ovarian cancer is seen in \nSelect and explain. \nA. Hereditary nonpolyposis colorectal cancer, B. Peutz-jeghers syndrome, C. Cowden's syndrome, D. Ataxia telangiectasia", 'role': 'user'}, {'content': "Answer: A \nExplanation: HNPCC or Lynch II syndrome is caused by an inherited mutation in one of the following mismatch repair genes: hMSH2, hMLH1, PMS1, PMS2, or hMSH6. The disorder is characterized by early age (average age younger than 45 years) at onset of neoplastic lesions in a variety of tissues, including the colon, uterus, stomach, ureters, ovaries, and skin. The lifetime risk of endometrial cancer in women with Lynch II syndrome is 32% to 60% and the lifetime risk of ovarian cancer is 10% to 12%. Reference: Novak's gynecology; 14th edition; Chapter 35; Uterine cancer", 'role': 'assistant'}]