This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': "Finding on histopathological examination in the liver in case of malaria is - \nSelect and explain. \nA. Microabscess formation, B. Kupffer's cell hyperplasia with macrophage infiltration around periportal area laden with pigments, C. Non caseating granuloma, D. Non specific finding of neutrophilic infiltration", 'role': 'user'}, {'content': 'Answer: B \nExplanation: In severe infections with Plasmodium falciparum, the vital organs are packed with erythrocytes containing a mature form of the parasite.\nThere is abundant intra and extraerythrocytic pigment and organs such as liver, spleen and placenta may be\xa0grey black in colour.\n\nLiver and spleen in severe malaria\n\nThe liver is generally enlarged and maybe black from malarial pigment.\nThere is congestion of the centrilobular capillaries with sinusoidal dilatation and kupffer cell hyperplasia\nThe Kupffer cells are heavily laden with malarial pigment, parasites and cellular debris.\nSequestration of parasitized erythrocytes is associated with variable cloudy swelling of the hepatocytes and perivenous ischemic change and sometimes centrizonal necrosis.\nHepatic glycogen is often present despite hypoglycemia.\nThe spleen is often dark or black from malarial pigment, enlarged, soft and friable.\nIt is full of erythrocytes containing mature and immature parasites.\nThere is evidence of reticular hyperplasia and architectural reorganization.\nThe soft and acutely enlarged spleen of acute lethal infections contrasts with the hard fibrous enlargement associated with repeated malaria.', 'role': 'assistant'}]