This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Psychiatry
[{'content': 'Antipsychotic drugs act through \nSelect and explain. \nA. Dopamine D1 receptor blockade, B. Dopamine D2 receptor blockade, C. Dopamine D3 receptor blockade, D. Dopamine D4 receptor blockade', 'role': 'user'}, {'content': 'Answer: B \nExplanation: (B) Dopamine D2 receptor blockade # Antipsychotics work by blocking a specific subtype of the dopamine receptor, referred to as the D2 receptor.> Older antipsychotics, known as conventional antipsychotics, block the D2 receptor and improve positive symptoms.> Second generation of antipsychotics or Atypical antipsychotics, block D2 receptors as well as a specific subtype of serotonin receptor, the 5HT2A receptor.> It is believed that this combined action at D2 and 5HT2A receptors treats both the positive and the negative symptoms.> Atypical antipsychotics include clozapine, risperidone, olanzapine, quetiapine, paliperidone and ziprasidone.', 'role': 'assistant'}]