This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Concepts in physiology, Subject name: Physiology
[{'content': 'Which of the following events does not occur in M phase of mitosis? \nSelect and explain. \nA. Condensation of the chromosomes, B. Replication of the genome, C. Fragmentation of the nuclear envelope, D. Alignment of the chromatids along the equatorial plate', 'role': 'user'}, {'content': 'Answer: B \nExplanation: DNA replication occurs during the S phase of the cell cycle and precedes mitosis. Condensation of the chromosomes occurs during the prophase of mitosis. Fragmentation of the nuclear envelope occurs during the prometaphase of mitosis. The chromatids align at the equatorial plate during metaphase and separate into two complete sets of daughter chromosomes during anaphase.', 'role': 'assistant'}]