This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Myeloproliferative Disorders, Subject name: Pathology
[{'content': 'Person had severe pruritis while taking hot shower and presents with deep vein thrombosis. He also had JAK 2 mutation and hypeension. Which of the following is the most likely diagnosis of this patient? \nSelect and explain. \nA. Myelofibrosis, B. Polycythemia Vera, C. CML, D. AML', 'role': 'user'}, {'content': 'Answer: B \nExplanation: The presence of JAK2 mutation indicates that it is an example of Myeloproliferative disorder. Polycythemia vera is strongly associated with activating point mutations in the tyrosine kinase JAK2. Clinical features: Headache, dizziness, hypeension,Intense pruritus and peptic ulceration possibly resulting from the release of histamine from basophils. Hot showers ( AQUAGENIC PRURITUS ) will result in degranulation of the basophils thus releasing histamines.', 'role': 'assistant'}]