This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Pathology
[{'content': 'The type of mutation that leads to replacement of Valine for glutamate in Sickle Cell Disease is \nSelect and explain. \nA. Point mutation, B. Silent mutation, C. Nonsense mutation, D. None', 'role': 'user'}, {'content': 'Answer: A \nExplanation: .', 'role': 'assistant'}]