This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': "All of the following conditions have autosomal dominant inheritance except – \nSelect and explain. \nA. Fabry's disease, B. Marfan's syndrome, C. Osteogenesis imperfecta, D. Ehlers Danlos syndrome", 'role': 'user'}, {'content': 'Answer: A \nExplanation: Autosomal dominant disorders \n\nNormally a gene pair has two alleles.\nWhen one allele becomes abnormal due to mutation it is called heterozygous state.\nWhen both the alleles become abnormal due to mutation it is called homozygous state.\nAutosomal dominant disorders are manifested in heterozygous state, i.e. only if one allel is abnormal the disease will be manifested.\n\nAutosomal dominant disorders', 'role': 'assistant'}]