This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': "The subtype of Hodgkin's disease, which is histogenetically distinct from all the other subtypes, is - \nSelect and explain. \nA. Lymphocyte predominant, B. Nodular sclerosis, C. Mixed cellularity, D. Lymphocyte depleted", 'role': 'user'}, {'content': "Answer: A \nExplanation: Hodgkin's lymphoma can be divided into two groups.\n\n1. Classical Hodgkin lymphoma\n\nThis group includes\n\n\nNodular sclerosis\xa0 (iii) Lymphocyte-rich\nMixed cellularity\xa0\xa0\xa0 (iv) Lymphocyte-depletion\n\n\nThe Reed-Sternberg cells have similar immunophenotype, i.e., express CD 15 and CD 30.\n\n2. Lymphocytic predominance Hodgkin lymphoma\n\nThe Reed sternberg cells express CD 20 marker, characteristic B-cell immunotype.", 'role': 'assistant'}]