This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General, Subject name: Skin
[{'content': 'Acantholysis is: \nSelect and explain. \nA. Lysis of basale cell layer, B. Separation of keratinocytes, C. Thickening of granular layer, D. Thickening of corneum layer', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Ans. (b) Separation of keratinocytesRef: Harrison 19th ed. / 370* Keratinocytes are connected to one another by intracellular desmosomal bridges.* If there is loss of these desmosomal bridges, it will lead to separation of keratinocytes and the condition is known as acantholysis.* If separation continues, there will be intracellular edema, and the condition is known as Ballooning.Also Know* Degeneration of stratum basale is seen in: Lichen planus* Acanthosis: thickening of stratum spinosum* Hypergranulosis: Thickening of stratum granulosum* Hyperkeratosis: Thickening of stratum corneum* Parakeratosis: persistence of nucleus in stratum corneum layer', 'role': 'assistant'}]