This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Lipoprotein X is elevated in - \nSelect and explain. \nA. Primary biliary cirrhosis, B. Indian childhood cirrhosis, C. Hyper cholesterolemia, D. Alcoholic cirrhosis', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Lipoprotein x is an abnormal lipoprotein that is raised in conditions causing cholestasis.\nPrimary biliary cirrhosis is a cholestatic liver disease → So, lipoprotein X is elevated in PBC.\n\nPrimary biliary cirrhosis :-\n\nPrimary biliary cirrhosis is a chronic, progressive, and often fatal cholestatic liver disease characterized by\n\n\nThe destruction of intrahepatic bile ducts,\nPortal inflammation and\nScarring and the eventual development of liver failure.\n\n\nThe primary feature of this disease is a nonsuppurative. inflammatory, destruction of medium sized intrahepatic ducts. \n\nPathology\n\nThe main pathology of Primary biliary cirrhosis is obstruction of the intrahepatic biliary duct caused due to fibrosis.\nInitially there is infiltration of the chronic inflammatory cells such as plasma cells and lymphocytes followed by fibrosis.\nWith time, the obstruction to intrahepatic bile flow leads to progressive secondary hepatic damage.\nOver years to decades the parenchyma develops generalized cholestasis and relentless portal tract scarring and bridging fibrosis leads to cirrhosis.', 'role': 'assistant'}]