This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
[{'content': 'Which is true regarding IL-1? \nSelect and explain. \nA. Mainly derived from neutrophils, B. Produces necrosis of tumor cells, C. Increases expression of MHC coded proteins, D. Upregulates adhesion molecules', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Produced by tissue macrophages, monocytes, fibroblasts and dendritic cells and also expressed by B cells, lymphocytes, NK cells and epithelial cells Increases the expression of adhesion factors on endothelial cells to enable transmigration Causes fever, hyperalgesia, vasodilation and hypotension', 'role': 'assistant'}]