This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Anatomy
[{'content': 'Ram Prasad is admitted to Guru Teg Bahadur Hospital with respiratory infection for which antibiotic tobramycin is ordered. The clearance and vd of tobramycin in him are 160ml/min and 40L ,respectively.if you wish to give Ram Prasad and intravenous loading dose to achieve the therapeutic plasma concentration of 4mg/L rapidly, how much should be given \nSelect and explain. \nA. 0.1mg, B. 10mg, C. 115.2mg, D. 160mg', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ref-Katzung 10/e p45 Loading dise= Vd xtarget Plasma concentration =40Lx4mg/L =160mg clearance plays no role in the determination of loading dose. it is given to confuse you', 'role': 'assistant'}]