This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Drug distribution is influenced by: \nSelect and explain. \nA. Plasma protein binding, B. Lipid solubility, C. Degree of blood flow, D. All of these', 'role': 'user'}, {'content': 'Answer: D \nExplanation: - Factors affecting drug distribution\n\n\xa0Lipid solubility - Higher the solubility, higher the distribution\n\xa0Ionization at physiological pH - Higher the ionization, lower the distribution\nThe degree of plasma protein binding - More the binding, less the distribution\n\xa0Affinity for different tissues - Higher affinity, higher distribution\n\xa0Regional blood flow - More the flow, more the distribution\n\xa0Fat: lean body mass ratio (changes with age) - Increases with age\n\xa0Disease like CHF, uremia, cirrhosis', 'role': 'assistant'}]