This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous (Bio-Chemistry), Subject name: Biochemistry
[{'content': "Tryptophan deficiency leads to: \nSelect and explain. \nA. Her's disease, B. Lesch Nyhan syndrome, C. Hartnup disease, D. Alkaptonuria", 'role': 'user'}, {'content': "Answer: C \nExplanation: (C) Hartnup disease # Hartnup disease occurs due to impaired intestinal absorption and renal re-absorption of a neutral amino acid, tryptophan.> Tryptophan is required for synthesis of serotonin and nicotinic acid.> Neurological manifestations of Hartnup disease are due to decreased synthesis of serotonin while pellagra-like rash occurs due to decreased synthesis of nicotinic acid.> Her's disease (choice A) is caused by deficiency of liver phosphorylase.", 'role': 'assistant'}]