This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hemolytic anemia, Subject name: Pediatrics
[{'content': 'All of the following statements are true about sickle cell disease EXCEPT: \nSelect and explain. \nA. Patient may require frequent blood transfusions, B. Acute infection is the most common cause of moality before 3 years of age, C. There is positive correlation between concentration of HbS and polymerisation of HbS, D. Patient presents early in life before 6 months of life', 'role': 'user'}, {'content': 'Answer: D \nExplanation: - Patients of Sickle cell anemia rarely presents before 6 months age as abundance of HbF inhibits polymerisation of HbS. CLINICAL FEATURES OF SICKLE CELL ANEMIA: Hand foot syndrome / dactylitis of bones of hands, feet Priapism & erectile dysfunction Stroke & retinopathy- loss of visual acuity & blindness Auto splenectomy d/t splenic INFARCTS (Spleen becomes non palpable) Chronic hemolysis - pt may require frequent blood transfusions Renal Involvement- papillary necrosis & hyposthenuria cardiomegaly Infections mainly by encapsulated bacteria . - Fever in a child with sickle cell anemia is a medical emergency, require prompt medical evaluation and delivery of antibiotics because of increased risk of bacterial infection and subsequent high moality rate. - Positive correlation is seen b/w concentration of HbS & polymerization of HbS', 'role': 'assistant'}]