This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cytotoxic Anticancer Drugs, Subject name: Pharmacology
[{'content': 'Which anti-cancer drug affects DNA as well as RNA? \nSelect and explain. \nA. 5-FU, B. Methotrexate, C. Actinomycin-D, D. Etoposide', 'role': 'user'}, {'content': "Answer: C \nExplanation: Actinomycin-D is one of the anti-tumor antibiotic. It has two mechanisms of action: - It blocks RNA transcription by interfering with template function of DNA. - It causes single strand breaks in the DNA. It is used in the treatment of Wilm's tumor and rhabdomyosarcoma.", 'role': 'assistant'}]