This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Medicine
[{'content': 'Following investigations are required in initial evaluation of a chronic myeloid leukemia patient EXCEPT - \nSelect and explain. \nA. Peripheral smear, B. Test for Philadelphia chromosome, C. Bone marrow testing, D. HLA typing', 'role': 'user'}, {'content': 'Answer: D \nExplanation: CML is established by identification of the clone of hematopoietic stem cells that possesses the reciprocal translocation between chromosome 9 & 22,forming Philadelphia chromosome. Peripheral smear shows metamyelocytes, myelocytes, mature segmented neutrophils , basophils.Bone marrow examination reveals hypercellularity with predominance of myeloid cells.Reference:Harsh mohan textbook of pathology sixth edition pg no 357', 'role': 'assistant'}]