This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Which of the following tumors show increased -kit - \nSelect and explain. \nA. Yolk sac tumor, B. Embryonal carcinoma, C. Choriocarcinoma, D. Seminoma', 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans. is 'd' i.e., Seminoma o C KIT or CDII 7 is a proto-oncogene, overexpression or mutations of this protein can lead to cancer. o Activating mutations in this gene are associated with gastrointestinal stromal tumors, testicular seminoma, mast cell disease, melanoma, acute myeloid leukemia, while inactivating mutations are associated with the genetic defect piebaldism.", 'role': 'assistant'}]