This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': "Sickling in 'Hbs' disease is primaily caused by \nSelect and explain. \nA. Decreased Solubility, B. Decreased Stability, C. Altered function, D. Altered O2 binding capacity", 'role': 'user'}, {'content': 'Answer: A \nExplanation: The primary pathophysiological event in sickling is intracellular polymerization of deoxy-HbS due to its markedly reduced solubility.', 'role': 'assistant'}]