This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunity, Subject name: Pathology
[{'content': 'Anti-histone antibodies are diagnostic of? \nSelect and explain. \nA. Drug induced LE, B. Systemic sclerosis, C. Mixed connective tissue disorder, D. Sicca syndrome', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans is 'a' i.e., Drug induced LE * There is an extremely high frequency of antihistone antibodies drug induced LE.Generic antinuclear antibody-Most sensitive for SLEAnti ds DNA & anti smith (Sm)-Most specific for SLEAnti histone-Drug induced lupusAnti-Ro & Anti-La-Neonatal lupus with congenital heart block and sjogren syndromeAnti DNA Topoisomerase (Anti Scl-70)-Diffuse systemic sclerosis (Diffuse scleroderma)Anti - centromere-Localized systemic sclerosis (Localized scleroderma - CREST syndrome)Anti Jo-1 (Histidyl-t-RNA synthase)-Inflammatory myopathiesAnti U1 RNP-Mixed connective tissue disease", 'role': 'assistant'}]