This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Breast, Subject name: Pathology
[{'content': 'All of the following are invasive carcinoma breast except \nSelect and explain. \nA. Comedo carcinoma, B. Colloid carcinoma, C. Lobular carcinoma in situ, D. Medullary carcinoma', 'role': 'user'}, {'content': 'Answer: A \nExplanation: The comedo subtype is distinctive and is characterized by cells with high-grade nuclei with extensive central necrosis.The name derives from the toothpaste-like necrotic tissue that extrudes from transected ducts on application of gentle pressure ref : Robbins Basic Pathology, 9E,page-710', 'role': 'assistant'}]