This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Enzymes, Subject name: Biochemistry
[{'content': 'Which enzyme is deficient in c/c alcoholics? \nSelect and explain. \nA. Aconitase, B. Citrate synthase, C. Isocitrate dehydrogenase, D. Alpha ketoglutarate dehydrogenase', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ans. D. Alpha ketoglutarate dehydrogenaseBecause in alcoholics there is thiamine deficiency, so a thiamine dependent enzyme will be deficient.So answer is Alpha Ketoglutarate Dehydrogenase.', 'role': 'assistant'}]