This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
[{'content': 'The following affects the duration of action of Local Anesthesia, except \nSelect and explain. \nA. Protein binding capacity of Local Anesthetic, B. Addition of vasoconstrictor, C. Vasodilator activity of Local Anesthetic, D. Non-nervous tissue diffusibility', 'role': 'user'}, {'content': 'Answer: D \nExplanation: None', 'role': 'assistant'}]