This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.N.S, Subject name: Medicine
[{'content': 'Anti-epileptic that can be safely used in pregnancy \nSelect and explain. \nA. Valproic acid, B. Phenytoin, C. Carbamazepine, D. Lamotrigine', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Valproic acid is strongly associated with an increased risk of adverse fetal outcomes (7-20%). Recent findings from a large pregnancy registry suggest that other than topiramate, the newer antiepileptic drugs are far safer than valproic acid.Enzyme-inducing drugs such as phenytoin, carbamazepine, oxcarbazepine, topiramate, phenobarbital, and primidone cause a transient and reversible deficiency of vitamin K-dependent clotting factors in ~50% of newborn infants.Ref: Harrison 19e 2559', 'role': 'assistant'}]