This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Growth, Development, and Behavior, Subject name: Pediatrics
[{'content': 'Early eiphyseal closure is seen with \nSelect and explain. \nA. LH, B. FSH, C. Estrogens, D. Progesterone', 'role': 'user'}, {'content': "Answer: C \nExplanation: (Estrogens): Ref: 1859-Nelson 17thEstrogen has direct result of the known on promoting epiphyseal fusion and therapy must begin before the bone age has reached 12 years (Marfan's syndrome)* Recent studies have demonstrated that is estrogen that mediates epiphyseal fusion in both girls and boys* Androgens also accelerates skeletal maturation, presumably via aromatization to estrogens, but at the price of rapid virilization.", 'role': 'assistant'}]