This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Orthopaedics
[{'content': 'Treatment of postmenopausal osteoporosis -a) Tamoxifenb) Progesterone c) Estrogend) Alendronatee) Calcitonin \nSelect and explain. \nA. abd, B. acd, C. bde, D. cde', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Drug used in osteoporosis\n\nInhibit resorption : -Bisphosphonates, donesumab, cinacalcet, calcitonin, estrogen, SERMS, gallium nitrate.\nStimulate formation : -Teriparatide, calcium, calcitriol, fluorides,.\nBoth actions : - Strontium renelate.\n\n\nDrugs decreasing bone resorption initially increase bone mineral density (BMD), but it reaches a plateau in 2-3 yrs because bone formation also decreases.\nOn the other hand, drugs promoting bone formation can increase BMD through the period of treatment.\n\n\nSERMs (selective estrogen receptor modifier) used for osteoporosis → Raloxifene.\nBisphosphonates → Etidronate, Pamidronate, Alendronate, Ibandronate, Risedronate, Zolendronate.', 'role': 'assistant'}]