This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'Lactic acidosis  in  thiamine  deficiency  is  due  to which enzyme dysfunction? \nSelect and explain. \nA. Phosphoenol Pyruvate Carboxykinase, B. Pyruvate Dehydrogenase, C. Pyruvate Carboxylase, D. Aldolase', 'role': 'user'}, {'content': 'Answer: B \nExplanation: In Thiamine deficiency, PDH reaction is defective. So, pyruvate is converted to lactic acid.\nCauses of inhibition of PDH leading to lactic acidosis:\n\nInherited PDH deficiency\nThiamine deficiency\nAlcoholics due to thiamine deficiency\nArsenite and Mercury poisoning\n\nHarper 30th edition', 'role': 'assistant'}]