This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Dental
[{'content': 'Self-inﬂicted bites are seen in: \nSelect and explain. \nA. Lesch-Nyhan syndrome, B. Friese Maria syndrome, C. Cockayne syndrome, D. Brodie syndrome', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Lesch-Nyhan syndrome:\n\nInherited X-linked recessive disorder, affects only males.\nEnzyme defect – hypoxanthine guanine phosphoribosyl transferase (HGPRT)\nCharacterized by excess production of uric acid leading\xa0to GOUT.\nSelf-mutilation – bite their fingers and lips.\nNeurological abnormalities like mental – retardation, aggressive behavior, learning disability occur.\nNeurological symptoms may be due to dependence of brain on the salvage pathway.\nNephrolithiasis – leads to renal failure.', 'role': 'assistant'}]