This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Central Nervous system, Subject name: Pharmacology
[{'content': 'Which of the following opioid should not be used with MAO inhibitors \nSelect and explain. \nA. Pethidine, B. Pentazocine, C. Buprenorphine, D. Morphine', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Pethidine (Meperidine) Toxicity/overdose:- Overdose of pethidine produces many excita tory effects--tremors, mydriasis, hyperreflexia, delirium, myoclonus and convulsions. This is due to accumulation of norpethidine which has excitant effects. Nonselective MAO inhibitors interfere with hydrolysis but not with demethylation of pethidine--norpethidine is produced in excess and excitement occurs. So, pethidine should not be used with MAO inhibitors. Ref:- kd tripathi; pg num:-475', 'role': 'assistant'}]