This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Pharmacology
[{'content': 'About first-order kinetics, the true statement is \nSelect and explain. \nA. Clearance remains constant, B. Fixed amount of the drug is eliminated, C. Half life increase with dose, D. Decreased clearance with increasing dose', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Most of the drugs follow 1st order kinetics in 1st order kinetics-clearance is constant and, elimination is not saturable, and the rate of drug elimination is directly propoional to the concentration. This is usually referred to as first-order elimination Reference: Katzung Pharmacology; 13th edition; Chapter 3; Pharmacokinetics & Pharmacodynamics: Rational Dosing & the Time Course of Drug Action', 'role': 'assistant'}]