This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Hypercoagulability due to defective factor V gene is called \nSelect and explain. \nA. Lisbon mutation, B. Antiphospholipid syndrome, C. Leiden mutation, D. Inducible thrombocytopenia syndrome', 'role': 'user'}, {'content': 'Answer: C \nExplanation: • Mutation in factor V gene is caused by the substitution of glutamine for the normal arginine residue at position 506. It is known as Leiden mutation and it is the most common inherited cause of hypercoagulability.\nNote: Lisbon mutation is associated with a mutation in thyroid peroxidase gene.', 'role': 'assistant'}]