This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pancreas, Subject name: Pharmacology
[{'content': 'All of the following drugs act by increasing the secretion of insulin except? \nSelect and explain. \nA. Exenatide, B. Saxagliptin, C. Rosiglitazone, D. Glipizide', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Exenatide ->GLP-1 analogue - incretin which release insulin. S/E: Pancreatitis Saxagliptin -> DPP4 inhibitor which inhibit the metabolism of GLP-1, therefore increase insulin. Rosiglitazone acts PPAR gamma receptor. Reverse insulin resistance, associated with increase cardiovascular risk, Fluid retention,edema, anemia, weight gain, macular edema,bone fractures in women Glipizide is a sulfonylurea that increase release of insulin', 'role': 'assistant'}]