This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'A 25 year old women presents with a history of recurrent shortness  of breath and severe wheezing. Laboratory studies demonstrate that she a has a deficiency of C1 inhibitor, an esterase inhibitor that regulates the activation of the classical complement pathway. What is the diagnosis? \nSelect and explain. \nA. Chronic granulomatous disease, B. Hereditary angiodema, C. Myeloperoxidase deficiency, D. Wiskott-Aldrich syndrome', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Deficiency of C1 inhibitor, with excessive clearage of C4 and C2 by CLS, is associated with the syndrome of hereditory angioedema. This disease is characterised by episodic, painless, non pitting edema of soft tissue. It is the result of chronic complement activation, with the generation of a vasoactive peptide form C2 and may be life threatening because of the occurence of laryngeal edema.\nChronic granulomatous disease is due to a hereditory deficiency of NADPH oxidase\n\tMyeloperoxidase deficiency increases susceptibility to infections with candida.\nSelective IgA deficiency and Wiskott Aldrich syndrome are congenital immunodeficiency disorders associated with defects in Lymphocyte Function.', 'role': 'assistant'}]