This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': "Histological features of classical hodgkin's disease -a) Mixed cellularity seen in the backgroundb) Neoplastic cells more than non-neoplastic cells.c) Both neoplastic & non-neoplastic cells are seend) CD15 & CD 34 seene) Reed sternberg cells are seen \nSelect and explain. \nA. acd, B. bde, C. ace, D. ade", 'role': 'user'}, {'content': 'Answer: C \nExplanation: Distinct features of different types of Hodgkin lymphomas : -\nNodular sclerosis variant\n\nIt is the most common variant.\nIt is the only variant common in females.\nMost patients are young adults.\nFrequently involves mediastinum.\nLacunar cells are present on histology.\nIt has good prognosis → 2nd best after lymphocytic predominance.\n\n\nMixed cellularity variant\n\nIt is second most common variant.\nHas biphasic incidence, peaking in young adults and again in adults older than 55.\nMore common in males.\nMononuclear variants of Reed-Sternberg cells are present.\nLymphocyte depletion Type\nLeast common type\nWorst prognosis\nThere is paucity of lymphocytes.\nPleomorphic variants of RS cell are present.\nHodgkin cells (atypical histiocytes) are present.\nPredominant in older patients, HIV - positive individuals, or patients in developing countries.\nMost are EBV positive.\nMore common in males.\nLymphacytic Rich variant\nReactive lymphocytes make up the vast majority of the cellular infiltrate.\nMore common in males.\nIt has very good to excellent prognosis.\n40% are EBV positive.\nLymphocyte predominance type\nBest prognosis\nContains L & H (Popcorn cells) that are positive for CD 20.\nCommon in young males.\nFollicular dendritic cells are seen.\n\nThe diagnosis of classical hodgkin lymphoma requires the presence of both the characteristic neoplastic Reed-Sternberg cells and the characteristic non-neoplastic cellular environment comprising of lymphocytes, histocytes, granulocytes, eosinophils and plasma cells.', 'role': 'assistant'}]