This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
[{'content': 'A patient was being treated with a drug that interfaces with the activity of enzyme pyruvate ferredoxin oxidoreductase; Which of the following is the most likely organism causing infection in this patient? \nSelect and explain. \nA. Beef tapeworm, B. Whipworm, C. Cryptosporidium, D. Try panosoma', 'role': 'user'}, {'content': 'Answer: A \nExplanation: For Taenia saginata(Beef tapeworm): Praziquantel, Niclosamide Niclosamide Niclosamide is a highly effective drug against cestodes infesting man-Taenia saginata, T. solium, Diphyllobothrium latum and Hymenolepis nana, as well as threadworm. The drug appears to act by inhibiting oxidative phosphorylation in mitochondria and interfering with anaerobic generation of ATP by the tapeworm. Nitazoxanide: This salicylamide congener of the anthelmintic niclosamide, recently introduced for the treatment of giardiasis is also active against E. histolytica, T. vaginalis, Cryptosporidium, H. pylori, Ascaris, H. nana and some other protozoa and helminths. It is a prodrug which on absorption is conveed to the active form tizoxanide, an inhibitor of PFOR enzyme that is an essential pathway of electron transpo energy metabolism in anaerobic organisms ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SIXTH EDITION PAGE NO:802,814', 'role': 'assistant'}]