This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autacoids, Subject name: Pharmacology
[{'content': 'The therapeutic efficacy of antihypeensive drugs is blunted by NSAIDs because of : \nSelect and explain. \nA. Cause sodium excretion, B. Increase in the clearance of antihypeensive drugs, C. Decrease in the absorption of antihypeensive drugs, D. Decrease in the synthesis of vascular prostacyclin', 'role': 'user'}, {'content': 'Answer: D \nExplanation: NSAIDs inhibit Prostaglandin production including PGI2 which causes vasodilatation Ref: KD Tripathi 8th ed', 'role': 'assistant'}]