This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Sumatriptan is used in - \nSelect and explain. \nA. Glaucoma, B. Migraine, C. Hypeension, D. Opioid withdraw', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e., Migraine o Administered at the onset of an attack sumatriptan is as effective and better tolerated than ergotamine. o It tends to suppress nausea and vomiting of migraine, while ergotamine accentuates these symptoms. o Mechanism of action : 1. In migraine, there is throbbing headache due to dilatation of pain sensitive aeries outside the brain (extracerebral) Sumatriptan provides relief by 5-HT 1D/1B receptor mediated constriction of dilated cranial extracerebral vessels. 2. In migraine, there is perivascular neurogenic inflammation occurs due to realease of endogenous neurotransmitter -->sumitriptan inhibit neurotransmitter release.", 'role': 'assistant'}]