This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
[{'content': 'SMAC/DIABLO is a \nSelect and explain. \nA. Anti apoptotic protein, B. Induces necrosis, C. Acts both as anti and pro apoptotic protein, D. Pro-apoptotic protein', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Diablo homolog (DIABLO) is a mitochondrial proteinthat in humans is encoded by the DIABLO (direct IAPbinding protein with low pI) gene on chromosome 12. DIABLO is also referred to as second mitochondria-derived activator of caspases or SMAC. This protein binds inhibitor of apoptosis proteins (IAPs), thus freeing caspases to activate apoptosis. Due to its proapoptotic function, ref Robbins 9/e p 19, and internet', 'role': 'assistant'}]