This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Physiology
[{'content': 'Clotting factors that is not affected in liver disease is? \nSelect and explain. \nA. Factors II, B. Factor IV, C. Factor IX, D. Factor VIII', 'role': 'user'}, {'content': "Answer: D \nExplanation: Factor VIII REF: Ganong's 22nd ed p. 545 All clotting factors except VIII are produced by liver, which is produced by vascular endothelium", 'role': 'assistant'}]