This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Physiology
[{'content': 'Initiating event of Endotoxic shock \nSelect and explain. \nA. Endothelial injury, B. Peripheral vasodilata on, C. Cytokinin action, D. Decreased pumping of hea', 'role': 'user'}, {'content': "Answer: C \nExplanation: The receptor for the endotoxin in humans is the TLR-4 located on the surface of antigen presenting cells. b. Binding to the receptor activates a cascade of enzymatic reactions which finally leads to the activation of the genes for the proinflammatory cytokines. Ref ganong's review of medical physiology 25e p465", 'role': 'assistant'}]