This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: GIT, Subject name: Surgery
[{'content': "All of the following are true about diffuse gastric cancer according to Lauren's classification except: \nSelect and explain. \nA. Familial, B. more common in males, C. undifferentiated, D. more common in the proximal pa", 'role': 'user'}, {'content': "Answer: B \nExplanation: Lauren Classification System for carcinoma Intestinal Diffuse - Environmental - Gastric atrophy, intestinal metaplasia - Men > Women - Increasing incidence with age - Gland formation - Hematogenous spread - Microsatellite instability - APC gene mutations - p53, p16 inactivation - Epidemic - Distal pa of the stomach - Familial - Blood group 'A' - Women > Men - Younger age group - Poorly differentiated signet ring cells - Transmural/ Lymphatic spread - Decreased E-cadherin - p53, p16 inactivation - Endemic - Proximal pa of the stomach", 'role': 'assistant'}]