This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
[{'content': 'Regarding HIV which of the following is not true ? \nSelect and explain. \nA. It is a DNA retrovirus, B. Contains Reverse Transcriptase, C. may infect host CD4 cells other than T lymphocytes, D. Causes a reduction in host CD4 cells at late stage of disease', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., It is a DNA retrovirus HIV is a RNA virus (not DNA) It contains reverse transcriptase enzyme, which is a characteristic feature of retroviruses. The receptor for the virus is the CD4 antigen on surface. The cells affected are : - CD4 T Cells (major target) - B lymphocytes - Monocytes and macrophages - Langerhans cells in dermis Glial cells and microglia in the CNS - Follicular dendritic cells from tonsils can be infected by HIV without the involvement of CD4 CD4 T cells are reduced and T4:T8 Cell ratio is reversed", 'role': 'assistant'}]