This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
[{'content': 'Which one of the following does not indicate good prognosis in Ca penis: \nSelect and explain. \nA. Size less than 2 cm, B. No regional lymph node metastasis, C. No invasion of subepithelial connective tissue, D. No metastases', 'role': 'user'}, {'content': "Answer: A \nExplanation: It is not the size of the tumor but the invasion of the lesion into the corpora or overlying facial layers, which are prognostic indicator.\nLymph node status is the most important prognostic marker of the disease.\nHere's the TNM staging of penile cancer", 'role': 'assistant'}]