This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Virology, Subject name: Microbiology
[{'content': 'Active replication in Hepatitis B infection is indicated by ? \nSelect and explain. \nA. HBeAg, B. HBsAg, C. HBcAg, D. Anti-HBsAg', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Circulating HBeAg is an indicator of active intra hepatic viral replication REF:ANANTHANARYANAN TEXT BOOK OF MICROBIOLOGY 9EDITION PGNO.547', 'role': 'assistant'}]