This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Phenylalanine and Tyrosine metabolism Detail, Subject name: Biochemistry
[{'content': 'Nitisinone is an example of \nSelect and explain. \nA. Enzyme activation therapy, B. Enzyme replacement therapy, C. Substrate addition therapy, D. Substrate reduction therapy', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Nitisinone is prescribed for infantile tyrosinemia because it decreases production of the substrate (fumarylacetoacetate) for the hydrolase, thus decreasing the velocity of the reaction preventing substrate accumulation.', 'role': 'assistant'}]