This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'In acute inflammation due to the contraction of endothelial cell cytoskeleton, which of the following results \nSelect and explain. \nA. Delayed transient increase in permeability, B. Delayed permanent increase, C. Early permanent increase, D. Early transient increase', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Since the two major mechanisms of host defence against microbes i.e. antibodies and leucocytes are normally\xa0carried in the bloodstream, it is not surprising that vascular phenomenon plays a major role in acute inflammation\xa0\nNormally, plasma proteins and circulating cells are sequestered inside the vessels and move in the direction of flow.\nIn inflammation, blood vessels undergo a series of changes that are designed to maximize the movement of\xa0plasma proteins and circulating cells out of the circulation and into the site of injury or infection.\n\nChanges in vessel\nThe changes occur in the following order\n(i) Vasodilatation - the Earliest manifestation of acute inflammation\xa0sometimes it follows a transient constriction of arterioles.\nii. Vasodilation is quickly followed by increased permeability of the microvasculature.\niii. Stasis - Increased vascular permeability • The hallmark of acute inflammation\xa0is increased vascular permeability Acute\xa0inflammation\xa0has three major steps: -', 'role': 'assistant'}]