This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pharmacology
[{'content': 'Causes of reduced bioavailability of a drug includes \nSelect and explain. \nA. High first pass metabolism, B. Increased absorption, C. IV drug administration, D. High lipid solubility', 'role': 'user'}, {'content': 'Answer: A \nExplanation: When the metabolism of a drug is high during its passage from the site of absorption into the systemic circulation, the rate, and extent of absorption of that drug decreases. absorption- amount of drug reaching the systemic circulation from the site of administration (Ref.Essentials of medical pharmacology TD Tripathi 7th edition page no.16,27)', 'role': 'assistant'}]