This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
[{'content': 'Which of the following are alkylating agents: \nSelect and explain. \nA. Cyclophosphamide, B. Ifosfamide, C. Paclitaxel, D. Methotrexate', 'role': 'user'}, {'content': 'Answer: A \nExplanation: ALKYLATI NG AGE NTS These compounds produce highly reactive carbonium ion intermediates which transfer alkyl groups to cellular macromolecules by forming covalent bonds. The position 7 of guanine residues in DNA is especially susceptible, but other molecular sites are also involved. Alkylation results in cross linking/ abnormal base pairing/ scission of DNA strand. Cross linking of nucleic acids with proteins can also take place. >Mechlorethamine (Mustine HCL) >Cyclophosphamide >Ifosfamide >Chlorambucil >Melphalan >Thio-TEPA >Busulfan >Nitrosoureas >Dacarbazine(DTIC) ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SIXTH EDITION PAGE NO:821,822', 'role': 'assistant'}]