This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General Pharmacology, Subject name: Pharmacology
[{'content': 'Apparent volume of distribution (Vd) of a drug exceeds total body fluid volume, if a drug is: \nSelect and explain. \nA. Sequestrated in body tissues, B. Slowly eliminated from body, C. Poorly soluble in plasma, D. Highly bound to plasma proteins', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. (A) Sequestered in body tissues(Ref: KDT 8th/e p24)* Apparent volume of distribution (Vd ) is more for drugs sequestered in tissues.* Lipid insoluble drugs do not enter cells, Vd approximates ECF volume.', 'role': 'assistant'}]