This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'True regarding clavulanic acid is ? \nSelect and explain. \nA. Deactivates beta lactamase, B. Decreases renal excretion of amoxycillin, C. Potentiates action of penicillin, D. Decreases the side effects of amoxicillin', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Deactivates Beta lactamase Clavulanic acid Clavulanic acid is a beta-lactamase inhibitor. Addition of clavulanic acid re-estabilishes the activity of amoxicillin against (3-lactamase producing organisms. Clavulanic acid has a b-lactam ring but no antibacterial activity of its own. Clavulanic acid is a suicide inhibitor, it gets inactivated ofter binding to the enzyme because of ireversible binding. Clavulanic acid is a progressive inhibitor, binding is reversible initially, but become irreversible later due to covalent bonding, i.e. inhibition increases with time. Other beta-lactamase inhibitors Sulbactam is combined with ampicillin. Tazobactom is combined with piperacillin.", 'role': 'assistant'}]