This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autoimmune Skin Disorders, Subject name: Skin
[{'content': "Patient with pruritic lesion over Left shoulder showing cigarette paper atrophy and poikiloderma with generalized lymphadenopathy. Histopathologv exmanination of lesion shows CD4 positive sezary leutzner cells. What is the dermo- epidermal manifestation of this disease? \nSelect and explain. \nA. Pautrier's micro abscess, B. Pin point ulcers, C. Discharging sinus, D. Miliaria", 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Pautrier's micro abscess o Patient with pruritic lesion over Left shoulder showing cigarette paper atrophy and poikiloderma with generalized lymphadenopathy. Histopathologv exmanination of lesion shows CD4 positive sezary leutzner cells - points to the diagnosis of Mycosis fungoides.HistplogicaLfeatures of mycpsis fungoideso Histological hallmark is the presence of sezary-Lutzner cells (CD4 positive).o These sezary-Lutzner cells form band like aggregates within superficial dermis and invade epidermis as single cells and small clusters, referred to as pautrier microabscess,o There is pronounced infiltration of sezary-lutzner cells into epidermis which is referred to as epidermotropism.o In more advanced nodular stage these malignant T cells (sezary cells) lose their epidermotropic tendency and grow deeply into the dermis, and eventually seed lymphatics and peripheral circulation.", 'role': 'assistant'}]