This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Pathology
[{'content': 'Translocation of bcr-abl gene is characteristically seen in- \nSelect and explain. \nA. Chronic myeloid leukemia, B. Acute myeloid leukemia, C. Chronic lymphatic leukemia, D. Acute lymphatic leukemia', 'role': 'user'}, {'content': 'Answer: A \nExplanation: In CML BCR-ABL directs the synthesis of a constitutively active BCR-ABL tyrosine kinase , which in CML is usually 210kDa in size . In more than 90% of cases ,BCR - ABL is created by reciprocal translocation ( the so called Philadelphia chromosome) Ref: Robbins. Pathologic basis of disease ;pg 616', 'role': 'assistant'}]