This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cellular Pathology, Subject name: Pathology
[{'content': 'Antinuclear antibody specific for SLE is - \nSelect and explain. \nA. Anti ds DNA, B. Anti nuclear antibodies, C. Anti centromere antibody, D. Anti histone Ab', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Anti ds DNA o Generic antinuclear antibody-Most sensitive for SLE.o Anti ds DNA & anti smith (Sm)-Most specific for SLE.o Anti histone-Drug induced lupus.o Anti-Ro & Anti-La-Neonatal lupus with congenital heart block and sjogren syndrome,o Anti DNA Topoisomerase (Anti Scl-70)-Diffuse systemic sclerosis (Diffuse scleroderma),o Anti - centromere-Localized systemic sclerosis (Localized scleroderma - CREST syndrome).o Anti Jo-1 (Histidyl-t-RNA synthase)-Inflammatory myopathies,o Anti U1 RNP-Mixed connective tissue disease.", 'role': 'assistant'}]