This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'Hormone that stimulates gluconeogenesis is: \nSelect and explain. \nA. Glucagon, B. Epinephrine, C. None of the above, D. Both of the above', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ans:D.)Both of the Above. Glucagon and epinephrine, hormones that are responsive to a decrease in blood glucose, inhibit glycolysis and stimulate gluconeogenesis in the liver by increasing the concentration of cAMP. This in turn activates cAMP-dependent protein kinase, leading to the phosphorylation and inactivation of pyruvate kinase. They also affect the concentration of fructose 2,6-bisphosphate and therefore glycolysis and gluconeogenesis Ref: Harper 28thedition, chapter 20.', 'role': 'assistant'}]