This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Bleeding Disorders, Subject name: Pathology
[{'content': 'Hemophilia is associated with - \nSelect and explain. \nA. X Chromosome, B. Y Chromosome, C. Chromosome 3, D. Chromosome 16', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., X chromosome o Hemophilia A is caused due to defect or decrease in factor VIII.o The factor VIII gene is one of the largest genes known comprising about .l%of the X chromosome.o Factor VIII contains several areas of internal homology '.Hemophilia A geneso Hemophilic gens does not demonstrate a uniform abnormality, instead numerous different mutations in the Factor VIII gene have been described.o Seven different mutations have been demonstrated in the hemophilia gene.o Most common mutation associated with hemophilia A is major inversion of a section of the tip of the long arm of X chromosome.", 'role': 'assistant'}]