This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': 'Cholestatic jaundice is associated with all of the following, except: \nSelect and explain. \nA. Predominantly conjugated hyperbilirubinemia, B. Minimal biochemical changes of parenchymal liver damage, C. A moderate to marked increase in serum alkaline phosphatase, D. A moderate to marked increase in SGOT', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Clinical features\xa0comprise those due to cholestasis\xa0itself, those due to secondary infection (cholangitis) and those\xa0of the underlying condition. Obstruction of the bile\xa0duct drainage due to blockage of the extrahepatic biliary tree\xa0is characteristically associated with pale stools and dark urine.\xa0\xa0\n\xa0\nPruritus may be a dominant feature and can be accompanied\xa0by skin excoriations. Peripheral stigmata of chronic liver disease\xa0are absent. If the gallbladder is palpable, the jaundice is unlikely\xa0to be caused by biliary obstruction due to gallstones, probably\xa0because a chronically inflamed, stone-containing gallbladder\xa0cannot readily dilate. This is Courvoisier’s Law, and suggests that jaundice is due to a malignant biliary obstruction (e.g. pancreatic cancer). Cholangitis is characterised by ‘Charcot’s\xa0triad’ of jaundice, right upper quadrant pain and fever. Cholestatic\xa0jaundice is characterised by a relatively greater elevation of ALP\xa0and GGT than the aminotransferases.\xa0\xa0\n\xa0\nKey Concept:\nCholestatic jaundice is associated with predominantly conjugated hyperbilirubinemia. There is minimal biochemical changes in parenchymal liver damage.', 'role': 'assistant'}]