This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autacoids, Subject name: Pharmacology
[{'content': 'Which of the following disease modifying anti-rheumatic drugs (DMARDs) is the drug of first choice? \nSelect and explain. \nA. Methotrexate, B. Gold compounds, C. D-penidillamine, D. Anakinra', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Methotrexate: DMARD of 1st choice Folate antagonist Potent immunosuppressant and anti-inflammatory action Beneficial effects in RA are probably related to inhibition of cytokine production, chemotaxis, and cell-mediated immune reaction. Induction of oral low-dose 7.5-15mg) weekly MTX regimen has improved acceptability of this drug in RA. The onset of symptoms relatively rapid (4-6 weeks), therefore preferred for initial treatment. Mtx is now the Drug of first choice and the standard treatment for most patients, including cases of juvenile RA. ESSENTIALS OF MEDICAL PHARMACOLOGY;7TH EDITION;KD TRIPATHI;PAGE NO 211', 'role': 'assistant'}]