This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: JIPMER 2019, Subject name: Pediatrics
[{'content': "False about hanup's disease \nSelect and explain. \nA. Defect in neutral aminoacid transpo, B. Mental retardation is the common presentation, C. Most children are asymptomatic, D. Photosensitivity", 'role': 'user'}, {'content': 'Answer: B \nExplanation: It is a rare inborn error of metabolism with autosomal recessive inheritance. Neutral amino acids, including tryptophan, are not transpoed across the brush border epithelium of the intestine and kidneys, This results in deficiency of synthesis of nicotinamide It causes a photo-induced pellagra-like syndrome. Cutaneous signs precede neurologic manifestations Eczematous, occasionally vesiculobullous eruption noted on the face and extremities in a glove-and-stocking photodistribution. Neurologic symptoms are fully reversible. Administration of nicotinamide and protection from sunlight improves both cutaneous and neurologic manifestations.', 'role': 'assistant'}]