This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cytogenetic Disorders, Subject name: Pathology
[{'content': 'The gene that regulates normal morphogenesis during development is : \nSelect and explain. \nA. FMR-1 gene, B. Homeobox gene., C. P-16, D. FTEN.', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e. Homeobox gene Homeobox geneis associated with normal morphogenesis.Their expression results in the production of localized cellular condensation of primitive mesenchyme in the sites of future bones.They play an important role in patterning of limbs, vertebrae and craniofacial structures.Mutations in Homeobox gene produces an extra digit between 3rd and fourth fingers as well as some degree of syndactyly.About other optionsFMR geneIt is familial mental retardation gene mutation in this gene causes Fragile-X- syndromePTENIt is phosphatase and tensin homologue.It is frequently deleted in many human cancers such as Glioblastomas, Prostate cancers, endometrial cancers and Breast cancer.P-16It is a tumour suppressor gene.", 'role': 'assistant'}]