This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: vitamins, Subject name: Biochemistry
[{'content': 'Which of the vitamin deficiency lead to lactic acidosis? \nSelect and explain. \nA. Riboflavin, B. Thiamin, C. Niacin, D. Panthotheic acid', 'role': 'user'}, {'content': 'Answer: B \nExplanation: thiamine deficiency in alcoholism may cause impairment of conversion of pyruvate to acetyl-CoA the result is increased plasma concentration of pyruvate and lactate, leading to lactic acidosis ref DM Vasudevan 8th ed page 467', 'role': 'assistant'}]