This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Ophthalmology
[{'content': "Leber's optic neuropathy- \nSelect and explain. \nA. Typically presents in the fourth decade of life, B. Males do not transmit the disease, C. Is inherited in autosomal X-link fashion, D. The optic disc is pale early in the disease", 'role': 'user'}, {'content': "Answer: B \nExplanation: Leber's hereditary optic neuropathy is a mitochondrial disorder. Since mitochondrial DNA is exclusively derived from mothers, males do not transmit the disease.\nThe optic disc becomes pale and atrophic in late atrophic phase (not early).", 'role': 'assistant'}]