This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Pathology
[{'content': 'most common leukemia in downsyndrome of less than 3yrs old is ? \nSelect and explain. \nA. ALL, B. AML-M5, C. HODGKINS LYMPHOMA, D. AML-M7', 'role': 'user'}, {'content': 'Answer: D \nExplanation: DOWNS SYNDROME : most commonly associated with ALL in less than 3 yrs old m/c is AML -M7 (MEGAKARYOCYTIC LUEKEMIA ) Clinical features * Life expectancy : 55 years (National Down Syndrome Society) * Physical appearances -- flat facial profile and an upward slant to the eye -- sho neck -- abnormally shaped ears -- white spots on the iris of the eye (called Brushfield spots) -- single, deep transverse crease on the palm of the hand. REF : ROBBINS 10TH ED', 'role': 'assistant'}]