This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Respiratory system, Subject name: Pharmacology
[{'content': 'Omalizumab is \nSelect and explain. \nA. Interleukin 2 receptor blocker, B. Anti IgE antibody, C. Anti IgM antibody, D. Leukotriene receptor blocker', 'role': 'user'}, {'content': 'Answer: B \nExplanation: ANTI-IgE ANTIBODY Omalizumab It is a humanized monoclonal antibody against IgE. Administered s.c., Mech of action:- It neutralizes free IgE in circulation without activating mast cells and other inflammatory cells. On antigen challenge, little IgE is available bound to the mast cell surface receptors (FceR1) to trigger mediator release and cause bronchoconstriction. In severe extrinsic asthma, omalizumab has been found to reduce exacerbations and steroid requirement. No benefit has been noted in nonallergic asthma. Ref:- kd tripathi; pg num:-231', 'role': 'assistant'}]