This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Nutrition & Digestion, Subject name: Biochemistry
[{'content': 'Toxicity of ethanol is due to: \nSelect and explain. \nA. Increased NADH/NAD+ ratio, B. Decreased lactate/pyruvate ratio, C. Inhibition of gluconeogenesis, D. Stimulation of fatty acid oxidation', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. A. Increased NADH/NAD+ ratioHigh concentration of NADH leads to high NADH/NAD+ ratio. This is the basic cause of all metabolic alteration in alcoholism.', 'role': 'assistant'}]