This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Which of the following drugs decreases hepatic glucose output and improves peripheral insulin utilization? \nSelect and explain. \nA. Chlorpropamide, B. Glyburide, C. Miglitol, D. Pioglitazone', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Thiazolidinediones, such as pioglitazone, are antidiabetic agents that increase insulin sensitivity through a variety of mechanisms that result in decreased hepatic gluconeogenesis and increased insulin-dependent muscle glucose uptake. Chlorpropamide is an oral hypoglycemic agent that is a sulfonylurea derivative. It stimulates secretion of insulin from the pancreas. Glyburide is a sulfonylurea derivative that stimulates insulin secretion from the pancreas. Miglitol is an antidiabetic agent that retards glucose absorption in the intestinal tract. The net result is a lowering of postprandial glucose levels.', 'role': 'assistant'}]