This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: miscellaneous, Subject name: Biochemistry
[{'content': 'Tangier disease is characterized by \nSelect and explain. \nA. Low HDL, B. Defective LDL receptors, C. No chylomicrons, D. Overproduction of VLDL', 'role': 'user'}, {'content': 'Answer: A \nExplanation: DyslipoproteinemiasDefectRemarksFamilial alpha-lipoprotein deficiencyTangier diseaseFish-eye diseaseApo-A-I deficienciesAll have a low or near absence of HDLA tendency toward hyperiacylglycerolemia as a resultof the absence of apo C-ll, causing inactive LPL. Low LDLlevels. Atherosclerosis in the elderlyRef: Harper&;s biochemistry; 30th edition; Chapter 26; Cholesterol Synthesis, Transpo, & Excretion', 'role': 'assistant'}]