This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Parasitology, Subject name: Microbiology
[{'content': 'Sabin Feldman exclusion test is used for diagnosis of: \nSelect and explain. \nA. Syphilis, B. Leptospirosis, C. Toxoplasmosis, D. Multiple myeloma', 'role': 'user'}, {'content': "Answer: C \nExplanation: Ans. c (Toxoplasmosis). (Ref. Harrison's medicine 16th ed. 1243)TOXOPLASMOSIS# Sabin-Feldman dye test is for trophozoites of Toxoplasma gondii.# IgG antibodies are primarily measured by the Sabin-Feldman Dye Test (DT).# The DT is a sensitive and specific neutralization test in which live organisms are lysed in the presence of complement and the patient's IgG T. gondii-specific antibody.# IgG antibodies usually appear within 1 to 2 weeks of the infection, peak within 1 to 2 months, fall at variable rates, and usually persist for life. The titer does not correlate with the severity of illness.# A positive DT establishes that the patient has been exposed to the parasite. A negative DT essentially rules out prior exposure to T. gondii (unless the patient is hypogammaglobulinemic).# In addition, rare cases of toxoplasmic chorioretinitis and TE (toxoplasmic encephalitis) in immunocompromised patients have been documented in patients negative for T. gondii-specific IgG antibodies.# Rx: Sulfadiazine + pyrimethamine.", 'role': 'assistant'}]