This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': 'Anticentromere antibodies are most commonly associated with: \nSelect and explain. \nA. Diffuse cutaneous systemic sclerosis, B. Mixed connective tissue disease, C. CREST syndrome, D. Polymyositis', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Anti-centromere antibodies react with protein antigens located in the kinetochore region of chromosomes and are present in 40 to 80% of patients with limited cutaneous scleroderma or CREST syndrome. So CREST syndrome is the single best answer of choice. Ref: Harrisons Principles of Internal Medicine, 16th Edition, Pages 1979, 1986.', 'role': 'assistant'}]