This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Non-depolarising Neuromuscular Blocking Agents, Subject name: Anaesthesia
[{'content': 'Neuromuscular blocker of choice in real failure: \nSelect and explain. \nA. Atracurium, B. Pancuronium, C. Rocuronium, D. Tubocurare', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans: A (Atracurium) Ref: Ajay Yadav's Short Textbook of Anaesthesia, 1st ed. Pg 89.Explanation:AtracuriumIt has a unique method of degradationIts metabolism is independent of hepatic and renal functionsIt undergoes HOFFMAN DEGREDATION (95%) and ester hydrolysis (5%) in plasmaSystemic effects,CVS: Can cause hypotension because of histamine releaseResp: Can cause Bronchospasm due to histamine releaseCNS: At higher doses, its metabolic product Laudanosine can precipitate convulsionsAllergic reactions from pruritic rash to angioedema can occurUsesAtracurium is relaxant of choice inHepatic failureRenal failureMyasthenia gravis", 'role': 'assistant'}]