This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Anaesthesia
[{'content': 'True about Epidural anesthesia: \nSelect and explain. \nA. Effects sta immediately, B. C/I in coagulopathies, C. Given in subarachnoid space, D. All', 'role': 'user'}, {'content': 'Answer: B \nExplanation: B i.e. C/I in coagulopathies Epidural anaesthesia is given in epidural spaceQ (extending from foramen magnum to sacral hiatus) not in subarachnoid spaceQ (which is used for intrathecal - spinal anesthesia). In comparison to spinal anesthesia, the volume of drug given is larger, onset on effect is delayed (5-20 min) and duration of action is prolongedQ in epidural anesthesia. Both epidural & spinal anesthesia block sympathetic outflow (T12 - L2). This produces dilation of resistance and capacitance vessels decreasing venous return & causing hypo-tensionQ. However, this fall is sudden & profound in spinal anesthesia, whereas slower & profound in epidural anesthesia. Centrineuraxial (spinal & epidural) anesthesia is contraindicated in coagulopathy, blood dyscariasis, full anticoagulant (oral warfarin, LMVV heparin & fibrinolytic) therapy but can be given to patients on antiplatelet agents like aspirin & NSAIDs.', 'role': 'assistant'}]