This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Febrile response in CNS is mediated by? \nSelect and explain. \nA. Bacterial toxin, B. IL-1, C. IL-6, D. All', 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans. is 'a' i.e., Bacterial toxin; 'b' i.e., IL-1; 'c' i.e., IL-6 Pyrogenes Pyrogenes are substances that cause fever. Pyrogens may be exogenous or endogenous Exogenous --> Bacterial toxins Endogenous --> IL-1, TNF-a, IL-6, Interferons, Ciliory's neurotropic factor These pyrogenes increase the level of PGE2 in the hypothalamus that elevates the thermoregulatory set point and causes fever.", 'role': 'assistant'}]