This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autacoids, Subject name: Pharmacology
[{'content': 'For pain control in a patient having history of G I bleeding, which of the following is given? \nSelect and explain. \nA. Nimesulide, B. Ibuprofen, C. Rofecoxib, D. Pentazocin', 'role': 'user'}, {'content': 'Answer: C \nExplanation: SELECTIVE COX-2 INHIBITORS- Rofecoxib,etoricoxib,celecoxib They cause little gastric mucosal damage; the occurrence of peptic ulcer and ulcer bleeds is clearly lower than with traditional NSAIDs. They do not depress TXA2 Production by platelets (COX-I dependent); do not inhibit platelet aggregation or prolong bleeding time but reduce PGI2 production by vascular endothelium. They increase the risk of cardiovascular events ESSENTIALS OF MEDICAL PHARMACOLOGY;7TH EDITION;KD TRIPATHI;PAGE NO 205', 'role': 'assistant'}]