This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Targeted Anticancer Drugs and Immunosuppressants, Subject name: Pharmacology
[{'content': 'Sirolimus is more likely to cause ____________ more than cyclosporine: \nSelect and explain. \nA. Hypeension, B. Osteoporosis, C. Renal insufficiency, D. Thrombocytopenia', 'role': 'user'}, {'content': 'Answer: D \nExplanation: * Sirolimus (rapamycin) results in suppression of bone marrow,mainly causing thrombocytopenia.other adverse effects are diarrhoea,liver damage and pneumonitis. * Cyclosporine and tacrolimus cause nephrotoxicity,hepatotoxicity,neurotoxicity as an adverse effect.', 'role': 'assistant'}]