This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': "Lowe's syndrome is characterised by the following except- \nSelect and explain. \nA. Hypophosphatamic rickets, B. Undescended testes, C. Defect in the CNS and eyes, D. Aminoaciduria", 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e., Undescendended testes Lowe's syndrome It is also known as oculocerebrorenal syndrome of Lowe. o It is X-linked disorder. It is characterized by : i) Congenital cataract ii) Mental retardation iii) Fanconi syndrome --> Aminoacidurina o The disease is caused by mutation in the OCRL1 gene, which encodes the phosphatidylinosital polyphosphate 5-phasphatase. Clinical features Progressive growth failure Hypotonia Fanconi syndrome Significant proteinuria Blindness Renal infufficiency Behavioural problems", 'role': 'assistant'}]