This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'Defect leading to thalassemia lies in – \nSelect and explain. \nA. Haemoglobin, B. Osmotic fragility, C. RBC membrane, D. Platelets', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Disorders off hemoglobin\n\nDisorders of hemoglobin may be of two types -\n\n1)\xa0\xa0 Qualitative defect of hemoglobin (hemoglobinopathy)\n\nHem oglobinopathies are disorders of hemoglobin, characterized by a defect that results in abnormal structure of one of the globin chain of hemoglobin.\nExamples are - Siclde cell anemia, HbC, HbE, HbD-Punjab, Hb O-Arab, Hb Lepore.\n\n2)\xa0\xa0 Quantitative defect of hemoglobin\n\nThese disorders are characterized by a defect that results in decreased rate of synthesis of one of the globin chain of hemoglobin.\nExample - Thalassemia', 'role': 'assistant'}]