This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Fluroquinolone mechanism of action in gram positive organism is by - \nSelect and explain. \nA. DNA gyrase, B. Topoisomerase II, C. Topoisomerase III, D. Topoisomerase IV', 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans. is 'd' i.e., Topoisomerase IV o The FQs inhibit the enzyme enzyme bacterial DNA gyrase in gram negative bacteria. In the gram - positive bacteria the major target of FQ action is a similar enzyme topoisomerase IV which nicks and separates daughter DNA strands after DNA replication.", 'role': 'assistant'}]