This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Bacteriology, Subject name: Microbiology
[{'content': 'Burkholderia cepacia is intrinsically resistant to: \nSelect and explain. \nA. Doxycycline, B. TMP-SMX, C. Polymyxin B, D. Meropenem', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Burkholderia cepacia complex strains are intrinsically resistant to a wide range of antimicrobial agents including Aminoglycosides, Polymyxin, First and Second generation cephalosporins and Carboxypenicillins. TMP-SMX, Meropenem and Doxycycline are the most effective agents in vitro and may be staed as first-line agents. Burkholderia cepacia: Gram Negative, rod-shaped, motile bacteria with obligate aerobic characteristic) Recognized as an antibiotic-resistant nosocomial pathogen in ICU patients Cause of the &;Cepacia syndrome&; in CF patient (Rapidly fatal syndrome of respiratory distress and septicemia) Intrinsically Resistant B.cepacia complex strains are intrinsically resistant to a wide range of anti microbial agents Susceptible Antimicrobial agents that are effective agianst B.cepacia complex in vitro include Aminoglycosides Polymyxins (Polymyxin B) First and Second generation of Cephalosporins Carbocypenicillins Trimethoprim-Suplhamethoxazole (Co-trimaxazole) Carbapenems (Meropenem) Cephalosporins (Third generation e.g., Ceftazidime) Ureidopenicillins Fluroquinolones Doxycycline or Minocycline Chloramphenicol Ref: Harrison&;s ; Ananthanarayana 10th edition/156', 'role': 'assistant'}]