This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
[{'content': 'The bacterial drug resistance in tuberculosis results from \nSelect and explain. \nA. Transduction, B. Transformation, C. Plasmid method, D. Mutation', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Refer Katzung 11/e p824 Resistance to INH occurs due to point mutation in inhA gene Resistance to Rifampicin occurs due to point mutation in rpoB gene Resistance to Ethambutol is due to mutation resulting in over expression of embB gene', 'role': 'assistant'}]