This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Regarding trastuzumab, all of the following are true except : \nSelect and explain. \nA. Shows better response in combination with paclitaxel, B. Used in non-metastatic breast cancer, C. Causes upregulation of HER2/neu, D. Do not cause bone marrow toxicity', 'role': 'user'}, {'content': 'Answer: C \nExplanation: None', 'role': 'assistant'}]