This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
[{'content': 'Which of the following is an inhibitor of RNA polymerase in eukaryotes ? \nSelect and explain. \nA. Alpha-amanitin, B. Rifampicin, C. Both, D. None', 'role': 'user'}, {'content': 'Answer: A \nExplanation: RNA polymerase II enzyme is inhibited by a-amanitin in eukaryotes. a-amanitin is a potent toxin produced by the poisonous mushroom Amanita phalloides (sometimes called "death cap"). a-Amanitin forms a tight complex with the polymerase, thereby inhibiting mRNA synthesis and, ultimately, protein synthesis. Rifampicin inhibits the prokaryotic DNA dependent RNA polymerase Reference: Harpers illustrated biochemistry 30th edition', 'role': 'assistant'}]