This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunology, Subject name: Microbiology
[{'content': 'Job syndrome is due to \nSelect and explain. \nA. Defect in chemotaxis, B. Defect in phagocytosis, C. Defect in synthesis, D. Defect in leukocyte function', 'role': 'user'}, {'content': "Answer: B \nExplanation: The autosomal dominant hyper-IgE syndrome also known as Job syndrome, characterized by the clinical triad of high serum IgE, recurring staphylococcal skin abscesses, and recurrent pneumonia with the formation of pneumatoceles.There is a defective immune response involving T lymphocytes, neutrophils and the cytokines they produce, especially interferon-gamma. Excessive levels of interferon-gamma result in marked elevation of immunoglobulin E.Disorders of phagocytosis:1.Chronic granulomatous disease2.Myeloperoxidase deficiency3.Chediak-Higashi syndrome4.Leukocyte G6PD deficiency5.Job's syndrome6.Tuftsin deficiency7.Lazy leukocyte syndrome8.Hyper- IgE syndrome9.Actin-binding protein deficiency10. Shwachman's diseaseRef: Ananthanarayan 9th edition, p172", 'role': 'assistant'}]