This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anticoagulants and Coagulants, Subject name: Pharmacology
[{'content': 'Recent oral direct thrombin inhibitor which can be used for prevention of stroke is: \nSelect and explain. \nA. Dabigatran, B. Ximelagatran, C. Lepirudin, D. Saxagliptin', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. (A) Dabigatran:(Ref: Katzung 11/e p594, CMDT 2012/537, KDT 8/e p671,672)Ximelagatran was the first oral direct thrombin inhibitor approved; however it was later withdrawn because of hepatotoxicity. Recently a new direct thrombin inhibitor dabigatran has been approved for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation. It is administered as a prodrug; dabigatran etexilate. It is not metabolized by CYP enzymes however dose adjustment is required in renal failure.', 'role': 'assistant'}]