This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
[{'content': 'Inherited defect in the extracellular glycoprotein called fibrillin-1 results in which disease? \nSelect and explain. \nA. Hereditary spherocytosis, B. Marfan syndrome, C. Marfan syndrome, D. Duchenne muscular dystrophy', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Robbins basic pathology 9th edition page no 220,Heading=marfans syndrome Marfan syndrome is a connective tissue disorder of autosomal dominant inheritance, the basic biochemical abnormality is a mutation affecting fibrillin. Fibrillin is encoded by FBN1gene, which maps to chromosomal locus15q21. Mutations in the FBN1gene are found in all patients with Marfan syndrome.', 'role': 'assistant'}]