This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pharmacology
[{'content': 'Which diuretic could be considered appropriate for combining with ACE inhibitors \nSelect and explain. \nA. Spironolactone, B. Eplerenone, C. Hydrochlorothiazide, D. Amiloride', 'role': 'user'}, {'content': 'Answer: C \nExplanation: ACE inhibitors are contra-indicated in the presence of hyperkalemia.Aldosterone antagonists and epithelial sodium channel blockers are potassium sparing diuretics and should not be combined with ACE inhibitors. Thiazides on the other hand cause hypokalemia and can be combined with ACE inhibitors.', 'role': 'assistant'}]