This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
[{'content': 'The most common secondary malignancy in a patient having retinoblastoma is \nSelect and explain. \nA. Osteosarcoma, B. Renal cell carcinoma, C. Pineoblastoma, D. Osteoblastoma', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ref Robbins 9/e p293 Retinoblastoma is the most common primary intraocular malignancy of children . involvement of both eyes with pineal gland gland is called as trilateral retinoblastoma The pinealoblastoma in association with retinoblastoma is a primary tumor In approximately 40% of cases, retinoblastoma occurs in individuals who inherit a germ line mutation of one RB alleles .This variant of retinoblastoma is inherited as an autosomal dominant trait and is associated with osteosarcoma . Osteosarcoma is therefore the commonest secondary malignancy associated with retinoblastoma', 'role': 'assistant'}]