This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Muscle, Subject name: Physiology
[{'content': 'In malignant hypehermia, excess heat production is due to: \nSelect and explain. \nA. Increased muscle metabolism by excess of calcium ions, B. Thermic effect of food, C. Increased sympathetic discharge, D. Mitochondrial thermogenesis', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Malignant hypehermia is an autosomal-dominant disease in which the defect is in RyR1 gene. When such individuals are administered inhalation anaesthetics (halothane or ether) or muscle relaxant succinylcholine , there is excess release of Ca++ in the sarcoplasm. This increases muscle metabolism.', 'role': 'assistant'}]