This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'B12 deficiency causes ? \nSelect and explain. \nA. Demyelination, B. Dermatitis, C. Burning foot syndrome, D. Beriberi', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., DemyelinationB12 in the form of Adenosyl B12 acts as a coenzyme for Methyl malonyl CoA mutase. Methyl Malonyl CoA mutase helps in the conversion of methyl malonyl CoA to Succinyl CoA.in B12 deficiency, methyl malonyl CoA accumulates. Methyl Malonyl CoA gets incorporated into fatty acids (instead of malonyl CoA).This results in abnormal fatty acids getting synthesized. When these fatty acids get incorporated in myelin, it results in rapid demyelination", 'role': 'assistant'}]