This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'All of the folloiwng statements about meglitinides are true, except: \nSelect and explain. \nA. Act by stimulating insulin release, B. Decrease postprandial hyperglycemia, C. Hypoglycemia is less common than with sulfonylureas, D. Act by decreasing insulin resistance', 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans is 'd' i.e. Act by decreasing insulin resistance o Though structurally unrelated to sulfonylureas, the meglitinides class of hypoglycemic drugs (Repaglinide and Nateglinide) bind to same ATP dependent K channels as do sulfonylureas and stimulate insulin secretion by closing these channels in pancreatic 13-cells-insulin secretogogue action. o The meglintinides are incapable of stimultating insulin secretion in nutrient-starved fl-cells but in the presence of glucose, they demonstrate hypoglycemic effects by augmenting the release of insulin. Consequently, meglitinides seem relatively unlikely to cause fasting hypoglycemia. o For the same reason, meglitinides effectively reduce post pradndial hyperglycemia as they demonstrate hypoglycemic effects in the presence of glucose.", 'role': 'assistant'}]