This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'The conjugation of bilirubin to glucuronic acid in the liver - \nSelect and explain. \nA. Converts a hydrophilic compound to a hydrophobic one, B. Converts a hydrophobic compound to a hydrophilic one, C. Enables the bilirubin molecule to cross the cell membrane, D. Is increased during neonatal jaundice', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Unconjugated bilirubin (hydrophobic) is converted to conjugated bilirubin (hydrophilic) by the process of conjugation with UDP-glucuronic acid in the liver.\nAs conjugated bilirubin is hydrophilic (not lipophilic) it cannot cross the plasma membrane easily (lipophilic or lipid soluble substances cross plasma membrane easily). Thus, unconjugated bilirubin (lipophilic) can cross plasma membrane easily but not conjugated bilirubin (hydrophilic).\nIn neonatal jaundice, conjugation process is immature.', 'role': 'assistant'}]