This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'In Sickle Cell Anaemia defect is in which chain: \nSelect and explain. \nA. Alphachain, B. Beta chain, C. Both the chains, D. None of these', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Beta chain', 'role': 'assistant'}]