This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
[{'content': 'Epigenetics deals with genetic modification that do not alter the sequence of DNA. All of the following can detect epigenetic modifications except \nSelect and explain. \nA. Chip on chip, B. Bisulphite method, C. HPLC, D. Methylation specific PCR', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Methods to detect epigenetic modifications Sequencing Chip on chip (Microarray) Using Methylation specific primers in PCR Bisulphite method: Bisulphite conves unmethylated cytosine to uracil. This can be detected by sequence analysis.', 'role': 'assistant'}]