This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
[{'content': 'Anticipation is seen in- \nSelect and explain. \nA. Translocation, B. Chromosome breaking, C. Trinucleotide-repeat expansion, D. Mitochondrial mutation', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Fragile X syndrome is the prototype of diseases in which the causative mutation occurs in a long repeating sequence of three nucleotides Anticipation: This term refers to the phenomenon whereby clinical features of fragile X syndrome worsen with each successive generation, as if the mutation becomes increasingly deleterious as it is transmitted from a man to his grandsons and great-grandsons. (Robbins Basic Pathology,9th edition,pg no. 241)', 'role': 'assistant'}]