This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Anaplasia is a hallmark feature of  _________. \nSelect and explain. \nA. Benign tumors, B. Malignant tumors, C. Both 1 & 2, D. Normal cell', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Anaplastic cells often display the following morphologic features:\n\nPleomorphism (i.e. variation in size and shape).\nNuclear abnormalities, consisting of extreme hyperchromatism\xa0(dark-staining),\xa0variation\xa0in\xa0nuclear\xa0size\xa0and shape, or unusually prominent single or multiple nucleoli.\xa0Enlargement of nuclei may result\xa0in\xa0an\xa0increased nuclear-to-cytoplasmic ratio that approaches 1:1 instead of the normal 1:4 or 1:6. Nucleoli may attain astounding sizes,\xa0sometimes approaching\xa0the\xa0diameter\xa0of normal lymphocytes.\nTumor giant cells may be formed.\xa0\nAtypical mitoses,\xa0which\xa0may\xa0be\xa0numerous.\xa0Anarchic multiple spindles may produce tripolar or quadripolar mitotic figures.\xa0\nLoss of polarity.\n\n\u200bReference-Robbins BASIC PATHOLOGY 10th edition pg-193', 'role': 'assistant'}]