This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.V.S, Subject name: Pharmacology
[{'content': 'Enhancement of the effects of bradykinin is most likely to occur with drugs like \nSelect and explain. \nA. clonidine, B. diazoxide, C. lisinopril, D. losartan', 'role': 'user'}, {'content': 'Answer: C \nExplanation: ACE inhibitors prevent the conversion of angiotensin I to angiotensin II and lower blood pressure by decreasing both the formation of aldosterone formation and the vasoconstrictive action of AII at AT-1 receptors. ACEIs also inhibit the metabolism of bradykinin, and this leads to additional hypotensive effects, because bradykinin is an endogenous vasodilator. Unfortunately, increases in bradykinin are associated with side effects, including cough and angioedema. Losartan, which blocks AT-1 receptors, does not increase bradykinin levels.', 'role': 'assistant'}]