This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Basic Concepts, Subject name: Pathology
[{'content': 'A 62-year-old man is brought to the emergency room in a disoriented state. Physical examination reveals jaundice, splenomegaly, and ascites. Serum levels of ALT, AST, alkaline phosphatase, and bilirubin are all elevated. A liver biopsy demonstrates alcoholic hepatitis with Mallory bodies. These cytoplasmic structures are composed of interwoven bundles of which of the following proteins? \nSelect and explain. \nA. a1-Antitrypsin, B. b-Amyloid (Ab), C. Intermediate filaments, D. Prion protein (PrP)', 'role': 'user'}, {'content': "Answer: C \nExplanation: Intermediate filaments -Hyaline is a term that refers to any material that exhibits a reddish, homogeneous appearance when stained with hematoxylin and eosin (H&E). -Standard terminology includes:- Hyaline aeriolosclerosis Alcoholic hyaline in the liver Hyaline membranes in the lung Hyaline droplets in various cells. -Alcoholic (Mallory) hyaline is composed of cytoskeletal intermediate filaments (cytokeratins) -Pulmonary hyaline membranes consist of plasma proteins deposited in alveoli. -Structurally abnormal a1-antitrypsin molecules (choice A) accumulate in the liver of patients with a1-antitrypsin deficiency. -a-Synuclein accumulates in neurons in the substantia nigra of patients with Parkinson's disease. Diagnosis: Alcoholic liver disease Prions (contain infectious proteins devoid of RNA or DNA)- CJD (Creutzfeldt-Jakob disease) Infective prions have misfolded proteins (alpha helix to beta sheet)", 'role': 'assistant'}]