This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
[{'content': 'In apoptosis, the nucleus is destroyed by \nSelect and explain. \nA. Endonuclease fragmentation, B. Karyolysis, C. Phagocytosis, D. Necrosis', 'role': 'user'}, {'content': 'Answer: A \nExplanation: In H&E-stained tissue sections, the nuclei of apoptotic cells show various stages of chromatin condensation and aggregation and, ultimately, karyorrhexis (Fig. 1-21); at the molecular level this is reflected in fragmentation of DNA into nucleosome-sized pieces. Ref Robbins 9/e p 18', 'role': 'assistant'}]