This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autonomic nervous system, Subject name: Pharmacology
[{'content': 'Which of the following is the longest acting Beta-blocker \nSelect and explain. \nA. Esmolol, B. Sotalol, C. Carvedilol, D. Nadalol', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Nadolol is a non-selective b-adrenergic antagonist that lacks intrinsic sympathomimetic activity and membrane-stabilizing propeies. Graeme Alexander, in Clinical Pharmacology (Eleventh Edition), 2012', 'role': 'assistant'}]