This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology and breast, Subject name: Surgery
[{'content': 'Risk of breast cancer is highest in \nSelect and explain. \nA. Lobular carcinoma in situ, B. Proliferative disease without atypia, C. Proliferative disease with atypia, D. Atypical ductal hyperplasia', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Atypical ductal or lobular hyperplasia are proliferative disease with atypia. Lobular carcinoma in situ carries the highest riskHISTOLOGIC DIAGNOSIS ESTIMATESRRNonproliferative disease1.0Proliferative disease without atypia1.3-1.9Proliferative disease with atypia3.7-4.2Proliferative disease with atypia and strong family history4-9LCIS >7Ref: Sabiston 20e, page: 832', 'role': 'assistant'}]