This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of nucleic acids, Subject name: Biochemistry
[{'content': 'Unwinding of DNA during replication is done by \nSelect and explain. \nA. Ligase, B. Helicase, C. Polymerase, D. Prinase', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Helicases are enzymes that bind and may even remodel nucleic acid or nucleic acid-protein complexes. There are DNA and RNA helicases. DNA helicases are essential during DNA replication because they separate double-stranded DNA into single strands allowing each strand to be copied Ref-Sathyanarayana 4/e', 'role': 'assistant'}]