This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Medullary carcinoma of Thyroid is characterized by all, except - \nSelect and explain. \nA. Hereditary in nature, B. Hormone dependent, C. Secretes Calcitonin, D. Amyloid stroma is seen', 'role': 'user'}, {'content': "Answer: B \nExplanation: Medullary carcinoma thyroid \n\nAccounts for approximately 7% of malignant tumour of the thyroid.\nIt arises from ultimobranchial bodies (from the parafollicular C cells derived from neural crest and not from thyroid follicles).\nIt contains amyloid stroma\nFamilial medullary carcinoma occurs in 25% of patients (Marfanoid habitus, Amyloidosis and Hirschsprung's disease also occur in patients with familial medullary cancer).\nMedullary carcinoma occurs in association with (MEN) syndrome.\nAll patients with medullary carcinoma of thyroid should be screened for RET point mutation on chromosome 10.\nMedullary Ca thyroid secretes calcitonin, this cause hypocalcemia. Calcitonin also acts as tumour marker.\nInvolvement of the lymph node is very common in medullary carcinoma. It is seen in 50-60% of cases.", 'role': 'assistant'}]