This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: mycology, Subject name: Microbiology
[{'content': 'When amphotericin B inhibits fungal growth, which mechanism is affected? \nSelect and explain. \nA. Inhibition of cell-wall synthesis, B. Inhibition of cytoplasmic membrane function, C. Inhibition of nucleic acid metabolism, D. Inhibition of protein synthesis', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Amphotericin B is a complex polyene that has no inhibitory effect against bacteria, but strongly inhibits several pathogenic fungi. Amphotericin B binds to sterols on the fungal cell membrane and disturbs cytoplasmic membrane function. Given intravenously as micelles of sodium deoxycholate dissolved in dextrose solution, the drug is widely distributed in tissues. It does not penetrate well to the cerebrospinal fluid. Once attached to the fungal membrane, an amphotericin pore is introduced. Small molecules and ions are lost, eventually resulting in cell death. Mammalian cells are relatively resistant to amphotericin because it binds weakly to the cholesterol in mammalian cell membranes.Amphotericin B is a broad-spectrum antifungal agent with activity against coccidioidomycosis, blastomycosis, histoplasmosis, sporotrichosis, cryptococcosis, mucormycosis, and candidiasis.Amphotericin B does not work by any of the other four antimicrobial mechanisms of action.', 'role': 'assistant'}]