This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Neoplastic Agents, Subject name: Pharmacology
[{'content': 'Which of the following is a cardiotoxic anticancer drug? \nSelect and explain. \nA. Bleomycin, B. Doxorubicin, C. 5 FU, D. Dactinomycin', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans: B (Doxorubicin) Ref: Goodman &Gillman's The Pharmacological Basis of Therapeutics, 2011. 12th Edition, McGraw Hill, Burton LL P 1712-1718Explanation:Cardiomyopathy is the most important long term toxicity of DoxorubicinIn the acute phase, ST and T wave changes and arrhythmias can be precipitated.Pericarditis- myocardiatis sy ndrome following infusion of this drug w hich either manifests as CHF with pericarditis and conduction disturbances.Cumulative toxicity is characterized by CHF and damage to myocardial fibrilsDexrazoxane may reduce troponin T elevation and cardio toxicity.Note:Pulmonary toxicity is the serious adverse reaction of Bleomycin.", 'role': 'assistant'}]