This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Lipids, Subject name: Biochemistry
[{'content': 'The deficient enzyme in Niemann-Pick disease is: \nSelect and explain. \nA. b-Glucosidase, B. Sphingomyelinase, C. b-Galactosidase, D. Cerebrosidase', 'role': 'user'}, {'content': "Answer: B \nExplanation: (Sphingomyelinase): Ref: 206-LP, 203-HP (56- R.S.7th)NIEMANN-PICK DISEASE: -* Sphingomyelinase deficiency* Enlarged liver and spleen filled with lipid* Severe mental retardation and neurodegeneration* Death in early childhood.* Tay-sach's disease (GM2-gangliosidosis): - hexosaaminidase A* GMi Gangliosidosis - b galactosidase* Metachromic Leukodystrophy (MLD): - Aryl sulfatase A* Fabry's disease - a - Galactosidase* Krabbe's disease - b Galactosidase* Gaucher's disease - b - Glucosidase* Farber's disease - Ceramide", 'role': 'assistant'}]