This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Which one of the following drugs increases gastrointestinal motility? \nSelect and explain. \nA. Glycopyrrolate, B. Fentanyl, C. Atropine, D. Neostigmine', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Neostigmine belongs to group Anticholinesterases (anti-ChEs) which are the agents which inhibit\xa0 ChE,\xa0 protect\xa0ACh\xa0from\xa0hydrolysis-produce cholinergic effects in vivo and potentiate ACh,\xa0both\xa0in\xa0vivo and\xa0in\xa0vitro. Quaternary ammonium\xa0 anti-ChEs\xa0like\xa0neostigmine\xa0have additional\xa0direct action\xa0on\xa0nicotinic\xa0cholinoceptors.\xa0\nACTIONS\xa0(of\xa0Ach)\nSmooth\xa0muscle\xa0in\xa0most organs\xa0is\xa0contracted\xa0(mainly\xa0 through\xa0 M3 receptors).\xa0Tone\xa0and\xa0peristalsis\xa0in\xa0the\xa0gastrointestinal\xa0tract\xa0is\xa0increased\xa0and\xa0sphincters\xa0relax\xa0leading to abdominal\xa0cramps\xa0and\xa0evacuation\xa0of bowel.\nThus, Neostigmine increases gastrointestinal motility.\nReference: Essentials of Medical Pharmacology Eighth Edition KD\xa0 TRIPATHI\xa0 page no 114,117', 'role': 'assistant'}]