This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
[{'content': 'A farmer presents with multiple dicharging sinuses in the leg not responding to antibiotics. Most likely diagnosis is - \nSelect and explain. \nA. Madurella, B. Actino-mycetoma, C. Nocardia, D. Sporothrix', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Madurella . Multiple discharging sinuses not responding to antibiotics suggest the diagnosis of mycetoma. . Actinomycetoma may respond to antibiotic therapy. eg. combination of streptomycin and dapsone or combination of streptomycin and trimethoprim sulfamethoxazole. . Actinomycetoma is caused by Actinomadura, Nocardia and streptomyces. . Eumycetoma rarely respond to antibiotics, some cases caused by madurella mycetoma have appeared to respond to ketoconazole or itraconazole.", 'role': 'assistant'}]