This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Which of the following agents enhances the bioavailability of levodopa - \nSelect and explain. \nA. Amantadine, B. Ropinirole, C. Entacapone, D. Selegiline', 'role': 'user'}, {'content': "Answer: C \nExplanation: Ans. is 'c' i.e., Entacapone o When peripheral decarboxylation of levodopa is blocked by carbidopa/benserazide, it is mainly metabolized by COMT to 3-0-methyldopa. o Blockade of this pathway by entacaptone/tolcapone fuher prolongs the t 1/2 of levodopa and allows a larger fraction of administered dose to cross to brain.", 'role': 'assistant'}]