This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Inflammation, Subject name: Pathology
[{'content': 'Which mediator of inflammation does NOT cause fever? \nSelect and explain. \nA. IL-1, B. TNF-a, C. Nitric Oxide, D. Prostaglandin', 'role': 'user'}, {'content': 'Answer: C \nExplanation: PYROGENS: Exogenous pyrogen : LPS Endogenous pyrogen : IL1/TNF alpha - NO is free radical causes vasodilation.', 'role': 'assistant'}]