This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': 'All are TRUE about diuretic associated hypokalemia, EXCEPT: \nSelect and explain. \nA. Loop diuretic cause more hypokalemia than thiazide diuretics, B. Increase in distal tubular Na+ delivery and distal tubular flow rate results hypokalemia, C. Secondary hyperaldosteronism also plays a role, D. Thiazides causes hypocalcuria', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Diuretic use is an impoant cause of hypokalemia. Thiazides cause more profound hypokalemia than loop diuretics. MUST KNOW: Mechanisms of hypokalemia in diuretic use: Increases distal tubular Na+ delivery and distal tubular flow rate in addition to secondary hyperaldosteronism. Thiazides have an effect on plasma K+ concentration greater than that of loop diuretics. It is due to thiazide-associated hypocalciuria versus the hypercalciuria seen with loop diuretics. It reduces the lumen-negative potential difference and attenuating distal K+ excretion. ALSO NOTE: High doses of penicillin-related antibiotics (nafcillin, dicloxacillin, ticarcillin, oxacillin, and carbenicillin) can increase K+ excretion. Aminoglycosides, amphotericin, foscarnet, cisplatin, and ifosfamide cause renal K+ and magnesium wasting, leading to hypokalemia and hypomagnesemia Ref: Harrison, Edition-18, page- 352.', 'role': 'assistant'}]