This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
[{'content': 'Genes involved in the development of colon carcinoma includes all of the following, except: \nSelect and explain. \nA. APC, B. DPC4, C. K-ras, D. Mismatch Repair Genes', 'role': 'user'}, {'content': 'Answer: B \nExplanation: DPC4 gene is on chromosome 18q, inactivation of this gene is associated with the development of pancreatic cancer. DPC4 gene encodes for a protein Smad4, which is involved in transforming growth factor beta signaling. APC gene, Beta-Catenin gene, K-ras mutation and Mismatch repair genes all are involved in the development of colorectal cancer. Ref: Pancreatic Cancer By John P. Neoptolemos, Page 125; Colon and Rectal Surgery By Marvin L. Corman, Pages 728-9; Caveolins in Cancer Pathogenesis, Prevention and Therapy By Isabelle Mercier, Page 19', 'role': 'assistant'}]