This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Pharmacology
[{'content': 'Indomethacin can antagonize the diuretic action of loop diuretics by: \nSelect and explain. \nA. Preventing prostaglandin mediated intrarenal-hemodynamic actions, B. Blocking the action in ascending limb of loop of Henle, C. Enhancing salt and water reabsorption in distal tubules, D. Increasing aldosterone secretion', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Loop diuretics release PGs that induce intrarenal hemodynamic changes which secondarily affect salt output. Indomethacin and other NSAIDs inhibit the formation of PG. Therefore, NSAIDs blunt the action of loop diuretics.', 'role': 'assistant'}]