This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pharmacokinetics, Subject name: Pharmacology
[{'content': 'Maintenance dose rate of a drug depends primarily on: \nSelect and explain. \nA. Volume of distribution, B. Half life, C. Lipid solubility, D. Total body clearance', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Maintenance dose rate = Clearance x Target Plasma concentration * Maintenance dose depends on clearance and target plasma concentration', 'role': 'assistant'}]