This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: FMGE 2018, Subject name: Biochemistry
[{'content': 'Atherosclerosis is associated with: \nSelect and explain. \nA. Lysine, B. Histidine, C. Homocysteine, D. Leucine', 'role': 'user'}, {'content': 'Answer: C \nExplanation: HOMOCYSTINURIA - HOMOCYSTEINE ACCUMULATION LEAD TO STROKE, ATHEROSCLEROSIS, MI, PULMONARY EMBOLISM Accumulation of derived amino acid Homocysteine, results due to deficiency of Cystathionine Synthase and Cystathionase as shown in figure below. C/F: -MENTAL RETARDATION -ECTOPIA LENTIS -SEIZURES -OSTEOPOROSIS MARFANOID HABITUS -SIMILAR TO MARFAN SYNDROME EXCEPT IN MARFAN LENS IS OUTWARDS AND UPWARDS *IN HOMOCYTINURIA - LENS IS DOWNWARDS AND INWARDS *HOMOCYSTEINE ACCUMULATION OCCURS IN CASE OF B6, B9 & B12 DEFICIENCY', 'role': 'assistant'}]