This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: AML & ALL, Subject name: Medicine
[{'content': 'Which is the most impoant prognostic marker in ALL? \nSelect and explain. \nA. Leucocyte count >50000, B. Hyperploidy, C. Response to treatment, D. Organomegaly', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Response to treatment is the most impoant prognostic marker in ALL. Leucocyte count> 50000/ul Poor prognosis Hyperploidy Favorable prognostic factor Response to treatment Remission status at 14 days of chemotherapy is best guide to prognosis. Organomegaly Poor prognosis. Lymph node, liver, spleen and testis enlargement indicate spread of cancer Unorable prognostic factors for ALL: Extreme age group: <1 year or >10 years Black males TLC>1 lac/cu.mm Organomegaly CNS Leukemia L2 ALL, pre B cell and mature B cell ALL Hypoploidy t(9:22) and t(4:11) Remission> 14 days', 'role': 'assistant'}]