This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Dental
[{'content': 'In children median diastema between maxillary permanent centrals closes with the eruption of \nSelect and explain. \nA. Maxillary permanent first premolar, B. Maxillary permanent central incisor, C. Maxillary permanent canines, D. Maxillary permanent second molars', 'role': 'user'}, {'content': 'Answer: C \nExplanation: None', 'role': 'assistant'}]