This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
[{'content': 'Retinoblastoma is associated with, which of the following tumors \nSelect and explain. \nA. Osteoclastoma, B. Hepatocellular carcinoma, C. Squamous cell carcinoma, D. Osteosarcoma', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ref Robbins 8/e p293 Childhood retino- blastoma is the most striking example of this category. Approximately 40% of retinoblastomas are familial. As is discussed later, inherited disabling mutations in a tumor suppressor gene are responsible for the development of this tumor in families. Carriers of this gene have a 10,000-fold increased risk of developing retinoblastoma. Unlike those with sporadic retinoblastoma, patients with familial retino- blastoma develop bilateral tumors, and they also have a greatly increased risk of developing a second cancer, par- ticularly osteosarcoma', 'role': 'assistant'}]