This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Reversible Cell Injury, Subject name: Pathology
[{'content': 'Acute inflammation resulting from activation of the inflammasome is mediated by the release of which of the following cytokines? \nSelect and explain. \nA. TNFa, B. IL-1b, C. IFNa, D. IFNg', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Inflammasome A cytosolic multiprotein complex Consists of NLRP-3 sensor, an adaptor and inactive Caspase-1 enzyme Triggered by NOD-like receptors (NLRs) which sense ingested microbial paicles (pathogenic bacteria) NLRs signal activates that cleaves a precursor form of the cytokine interleukin-1b (Pro IL-1b) to generate the biologically active form (IL-1b) IL-1b is a mediator of inflammation that recruits leukocytes and induces fever Inflammasome pathway may also play a role in mediating inflammation in common disorders such as gout, atherosclerosis, type 2 diabetes', 'role': 'assistant'}]