This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NEET 2018, Subject name: Pharmacology
[{'content': 'Amphotericin B acts on:- \nSelect and explain. \nA. Cell membrane, B. Cell wall, C. Nucleus, D. Cytoplasm', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Various drugs used in fungal infections with their mechanism of action are: Class of drugs Drugs bf action Polyenes * Amphotericin-B * Nystatin Bind to ergosterol and create pores in cell membrane. 5-flucytosine(5-FC) DNA polymerase inhibitor Azoles * Ketoconazole * Fluconazole * Itraconazole * Clotrimazole * Voriconazole Inhibits the enzyme lanosterol-14-a-demethylase resulting in reduced ergosterol synthesis. Allylamines * Terbinafine * Butenafine * Naftifine Inhibits squalene epoxidase-pores in cell membrane and accumulation of squalene(major factor) Griseofulvin Microtubule inhibition Echinocandins * Caspofungin Inhibit 1,3 beta glucan synthase enzyme resulting in inhibition of cell wall synthesis', 'role': 'assistant'}]