This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Medical & Surgical Illness Complication Pregnancy, Subject name: Gynaecology & Obstetrics
[{'content': 'A fetus was found to have congenital heart block what should be evaluated in the mother? \nSelect and explain. \nA. Apla Syndrome, B. Congenital heart defects, C. SLE, D. Hemolytic anemia', 'role': 'user'}, {'content': "Answer: C \nExplanation: Ans. (c) SLERef- Williams Obstetrics 25th Ed; Page No-1139-42* Congenital heart block develops almost exclusively in fetuses of women with antibodies to the SS-A or SS-B antigens for Anti-Ro (SS-A) antibody.* Prevalence rate with these antibodies are 30-49%.* Fetal cardiac monitoring is performed between 18 and 26 weeks' gestation in pregnancies with either of these antibodies.* Incidence of fetal myocarditis is only 2-3%; if these antibodies are present.Extra MileAutoantibodies produced in patients with systemic lupus erythematosus (SLE)AntibodyClinical associationsPrevalenceAntihistoneCommon in drug-induced lupus70%Anti-Ro (SS-A)Associated with sicca syndrome, predisposes to cutaneous lupus, neonatal lupus with heart block, reduced risk of nephritis30-49%Anti-La (SS- B)Associated with anti-Ro10-35%Anti-dsDNAMay correlate with disease activity, nephritis, and vasculitis Anti- RNPhigh titers associated with rheumatic syndromes33-40%Antinuclear (ANA)Best screening test, multiple antibodies; a second negative test makes SLE unlikely84-98Anti-Sm (Smith)Specific for SLE25-38%Antiphospho- lipidLupus anticoagulant and anticardiolipin anti bodies associated with thrombosis, fetal loss, thrombocytopenia, valvular heart disease; false positive test for syphilis21-50%AntierythrocyteDirect Coo m b s test, may develop hemolysis60%", 'role': 'assistant'}]