This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Medicine
[{'content': 'In DM type-II Insulin resistance develops due to \nSelect and explain. \nA. End organ target receptor insensitivity, B. DKA, C. HONK (Hyperosmolar nonketosis), D. Genetic', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. a (End organ target receptor insensitivity). (Ref. Harrison, Principles of Medicine, 18th/2109)DIABETES MELLITUSType 2 DM is usually characterized bya) Variable degree of insulin resistanceb) Impaired insulin secretionc) Increased glucose production# The distinct pathologic processes are end organ target receptor insensitivity and a genetic and metabolic defect in insulin secretion and action.# Amyloidosis of pancreas is also a cause.# Type 1A DM results from autoimmune beta-cell destruction (has tendency to develop ketosis)# While in Type IB DM the mechanism of destruction is not known.', 'role': 'assistant'}]