This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Blood, Subject name: Medicine
[{'content': 'Which is the most common cause of thrombocytopenia in an ICU patient? \nSelect and explain. \nA. Sepsis, B. Bone marrow failure, C. ITP, D. Drug induced', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Sepsis Thrombocytopenias in ICU patients :* Thrombocytopenia is a common laboratory abnormality that has been associated with adverse outcomes in ICU patients.* Thrombocytopenia is defined as platelet count < 150 X 103 cells / mcL.* Following table depicts the probable mechanisms and the causes for presence of thrombocytopenia in ICU patients.Thrombocytopenia in ICU : mechanisms and causesSix possible mechanisms* Hemodilution* Increased consumption* Increased destruction* Decreased production* Increased sequestration* Laboratory artifact (pseudothrombocytopenia) Specific causes* Sepsis, multiorgan failure* Trauma or major surgery* Bone marrow failure (leukemia, aplastic anemia)* Immune-mediated platelet consumption (ITP)* Drug induced (heparin, GPIIb/GPIIa inhibitors, antibiotics)* TIP and related disorders (HUS, TMA, and peripartum HELLP syndrome)* Sepsis is the most common cause accounting for 48% of the total patients of thrombocytopenia in ICU patients.* More than 25% of the patients have more than one associated cause.", 'role': 'assistant'}]