This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': "A 12 year old girl with the mood and emotional liability has a golden brown discoloration in descement membrane. Most likely diagnosis is – \nSelect and explain. \nA. Fabry's disease, B. Wilson's disease, C. Glycogen storage disease, D. Acute rheumatic fever", 'role': 'user'}, {'content': "Answer: B \nExplanation: Emotional liability, tremors (Neurological symptoms) with brown discoloration of descemet's membrane of coenea suggest the diagnosis of Wilson's disease.\n\nWilson's disease -\n\nIt occurs due to reduced mobilization of copper from lysosomes in liver cells for excretion into the bile.\nAbnormal gene for Wilson's disease is on long arm of chromosome 13 (AR).\n\tClinical features -\nYounger patient likely to develop hepatic involvement.\nLater on Neurologic manifestation like tremor, dystonia, behavioral changes also develops.\nK-F rings may be absent in young patients with liver diseases but are always present in patient with neurologic symptoms.\nHemolysis may be an initial manifestation.\nSensory changes never occur.\n\tDiagnosis -\nDecrease ceruloplasmin level\nLiver biopsy", 'role': 'assistant'}]