This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'Following are the findings in sickle cell Anemia, except – \nSelect and explain. \nA. Fish vertebra, B. Enlarged heart, C. Splenomegaly usually seen, D. Leukocytosis', 'role': 'user'}, {'content': "Answer: C \nExplanation: Splenomegaly is found in the early stage of sickle cell anemia. By continued infarction and hypoxia - leads to progressive scaring and shrinkage of the spleen, so that by adolescent or adulthood, only a small nubbin of fibrous tissue may be left; this is called autosplenctomy.\n\nAbout other options\nOption 'a'\nBone changes in sickle cell anemia are -\n\nCrew haircut appearance of skull bone\nFish mouth vertebrae\n\nOption 'b'\n\nCardiomegaly particularly increases in left ventricular dimension and mass results from an increase in cardiac output caused by chronic anaemia and has its onset in early childhood.\n\nOption 'd'\n\nThe WBC count is consistently elevated owing to an increase in the number of mature granulocytes. This increase is explained to a large extent by a shift of granulocytes from the marginated to the circulating compartments.", 'role': 'assistant'}]