This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Cyclosporin acts by inhibiting the proliferation of: \nSelect and explain. \nA. IL1, B. IL2, C. IL6, D. Macrophages', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Mechanism of action of cyclosporine Normally when antigen presenting cell (e.g. macrophage) present antigen to Helper T cell, there is activation of T cell by sequential intracellular eventsFirst calcium ions, after binding to calmodulin activate a membrane serine / threonine phosphatase called calcineurin. Calcineurin activates nuclear factor of activated T cells (NFAT) by dephosphorylation. Activated NFAT migrates to nucleus and induce transcription of cytokines IL-2 and other cytokinase. IL-2 activates T cells and cause proliferation of T cells. Cyclosporine enters target cells and bind to cyclophilin (an immunophilin). This cyclosporine – cyclophilin complex inactivates calcineurin IL-2 trascripitan and proliferation of T cells', 'role': 'assistant'}]