This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pharmacology
[{'content': 'Systemic adverse effects of long term inhaled steroids are evident only at doses more than - \nSelect and explain. \nA. 200 mcg/day, B. 400 mcg/day, C. 600 mcg/day, D. 800 mcg/day', 'role': 'user'}, {'content': "Answer: C \nExplanation: Ans. is 'c' i.e., 600 mcg/day Adverse effects of inhaled steroids* Hoarseness of voice, dysphonia, sore throat, asymptomatic or symptomatic oropharyngeal candidiasis are the most common side effects.* These can be minimized by the use of a spacer, gargling after every dose (to wash off the drug deposited on oral and pharyngeal mucosa) and prevented as well as treated by topical nystatin/clotrimazole.* There is no evidence of mucosal damage or increased incidence of chest infections, even on prolonged use.* Systemic effects of long-term inhaled glucocorticoids are clinically relevant only at doses > 600 mg/day. The significant ones are--mood changes, osteoporosis, growth retardation in children, bruising, petechiae, hyperglycaemia and pituitary-adrenal suppression; several reports of adrenal crisis have appeared, especially in children, during stress (of an infection, etc).* Inhaled steroids are safe during pregnancy.", 'role': 'assistant'}]