This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Pathology
[{'content': '. E-cadherin is more often mutated \nSelect and explain. \nA. Diffuse type of gastric cancer, B. Carcinoid tumour, C. Malignant ulcer of Stomach, D. Erosive gastritis', 'role': 'user'}, {'content': 'Answer: A \nExplanation: A germ line mutation in E-cadherin gene-loss of E-Catherine function-diffuse type of gastric cancer. Microscopy: it is composed of dis cohesive tumor cells(due to absence of E-cadherin) and do not form glands. Tumor cells contain abundant music which expands the cytoplasm and push the nucleus to periphery creating signet- ring cell appearance. GENERAL AND SYSTEMIC PATHOLOGY RAMDAS NAYAK SECOND EDITION PAGE 489 IMAGE REF: GENERAL AND SYSTEMIC PATHOLOGY RAMDAS NAYAK SECOND EDITION FIG:18-11A AND B PAGE 490', 'role': 'assistant'}]