This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'True about acute ITP – \nSelect and explain. \nA. Specific anti platelet antibodies detected, B. Viral infection predisposes as seen after vaccination, C. More common in children, D. All of these', 'role': 'user'}, {'content': "Answer: D \nExplanation: Specific anti platelet antibodies detected; 'c' i.e., Viral infection predisposes as seen after vaccination; `e' i.e., More common in children Pathogenesis of ITP (immune thrombocytopenia)\n\nChronic ITP is caused by the formation of autoantibodies against platelet membrane glycoproteins most often 11b-Hla or Ib-IX.\nAntibodies reactive with these membrane glycoprotein can be demonstrated in the plasma as well as bound to platelet surface in approximately 80% of the patients.\n\n\nIn overwhelming majority of cases the antiplatelet antibodies are of the IgG class.\nThe mechanism of platelet destruction is similar to that seen in autoimmune hemolytic anemias. Opsonized platelets are rendered susceptible to phagocytosis by the cells of the mononuclear phagocyte system.\nThe spleen is the major site of the destruction of platelets.\n\nThe differences between Acute & Chronic ITP are -", 'role': 'assistant'}]