This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': "Glanzmann's thrombasthenia is characterized by defective \nSelect and explain. \nA. Gp IB/IX, B. Gp IIB/IIIA, C. Gp IB/IIIA, D. Gp IIB/IX", 'role': 'user'}, {'content': "Answer: B \nExplanation: Glanzmann's thrombasthenia -\xa0It is an autosomal recessive disorder due to deficiency/dysfunction of glycoprotein Ilb-IIla (Gp Ilb/IIIa).\nThus there is defective platelet aggregation.\nPlatelet aggregation is normal to ristocetin(ln constant to Bernard Soulier syndrome) but no aggregation occurs in response to standard agonists (collagen,\xa0A DP, thrombin). Other differentiating features include normal platelet count and morphology.\xa0BT is prolonged. VWF is normal.\nThe disease manifests at birth with increased bleeding from umbilical cord stump.", 'role': 'assistant'}]