This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Mechanism of action of paclitaxel is : \nSelect and explain. \nA. Topoisomerase inhibition, B. Increases the polymerization of tubulin, C. Inhibits protein synthesis, D. Alkylation of DNA', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Taxanes (paclitaxel and docetaxel) act by increasing the polymerization of tubulin whereas vinca alkaloids (vincristine, vinblastine and vinorelbine) cause inhibition of tubulin polymerization. Both of these drugs act by causing the disruption of mitosis and are active in M-phase of the cell cycle.', 'role': 'assistant'}]