This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: miscellaneous, Subject name: Biochemistry
[{'content': 'Ladder pattern of DNA electrophoresis in apoptosis is caused by the action of the following enzyme \nSelect and explain. \nA. Endonuclease, B. Transglutaminase, C. DNAse, D. Caspase', 'role': 'user'}, {'content': 'Answer: A \nExplanation: 1.Apoptosis progresses quickly and its products are quickly removed, making it difficult or visualize. 2.During karyorrhexis endonuclease activation leaves sho DNA fragments, regularly spaced in size. 3.this gives a characteristic laddered appearance on agar gel electrophoresis. 4.This laddered pattern is characteristic but not specific for apoptosis..It may seen in necrosis also. Ref Endonuclease. Robbins 7 th /edition, pg 26, 27and 28.', 'role': 'assistant'}]