This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
[{'content': 'In severe hypospadias the possibility of an intersex problem is settled by - \nSelect and explain. \nA. Careful inspection of genitals, B. Biopsy for gonadal tissue, C. Karyotyping, D. Hormone assay', 'role': 'user'}, {'content': 'Answer: C \nExplanation: None', 'role': 'assistant'}]