This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Breast Cancer - Prognosis and Follow-Up, Subject name: Surgery
[{'content': 'Least risk of CA breast is seen in - \nSelect and explain. \nA. BRCA1, B. BRCA2, C. Li-Fraumeni syndrome, D. Ataxia telangiectasia', 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans. is 'd' i.e. Ataxia telangiectasia Only about 5 to 10% of breast cancers are caused by inheritance of germline mutations most important of which are BRCA-1 & BRCA-2.Percent Incidence of Sporadic, Familial, and Hereditary Breast CancerSporadic breast cancer 65-75%Familial breast cancer 20-30%Hereditary breast cancer 5-10%BRCA-145% BRCA-235% p53 (Li-Fraumeni Syndrome)1% STK 11/LKB1 (Peutz-Jeghners syndrome)<1% PTEN (Cowden disease)<1% MSH2/MLH1 (Muir Torre syndrome)<1% ATM (Ataxia-telangiectasia)<1% Unknown20%", 'role': 'assistant'}]