This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Proteins and Amino Acids, Subject name: Biochemistry
[{'content': 'Defect in folding of the protein result in which of the following clinical disease:- \nSelect and explain. \nA. Kuru, B. Migraine, C. Hypothyroidism, D. Myopia', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' Kuru .Prion diseases are known to occur because of defect in the secondary-tertiary protein structure (due to defect of folding of the peptide chain).Kuru is a prion disease.Other prion diseases are:Creutzfeldt-Jakob disease*Scrapie* (in sheep).Bovine spongiform encephalopathy* (in cattle).Note:Prion stands for proteinaceous infectious particle*.It contains no nucleic acid*.", 'role': 'assistant'}]