This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous (Bio-Chemistry), Subject name: Biochemistry
[{'content': "HMG-Co-A Reductase is associated with \nSelect and explain. \nA. Type 2 Diabetes, B. Familial Hypercholesterolemia, C. Gaucher's disease, D. Abetalipoproteinemia", 'role': 'user'}, {'content': 'Answer: B \nExplanation: (B) Familial Hypercholesterolemia # HMG-CoA reductase (or 3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGR) is the first enzyme of the HMG-CoA reductase pathway, the metabolic pathway that produces cholesterol and various other biomolecules.> HMG-CoA reductase is a polytopic, transmembrane protein that catalyzes a key step in the mevalonate pathway which is involved in the synthesis of sterols, isoprenoids and other lipids.> HMG-CoA reductase is the rate-limiting step in cholesterol synthesis and represents the sole major drug target for contemporary cholesterol-lowering drugs.', 'role': 'assistant'}]