This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Sterilization and Disinfection, Subject name: Microbiology
[{'content': 'Prions are best killed by - \nSelect and explain. \nA. Autoclaving at 121degC, B. 5% formaline, C. Sodium hydroxide, D. Sodium hypochloride', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ans. is \'c\' i.e., Sodium hydroxide o Incineration is apparently the only way of disinfecting prion-contaminated materials or tissues,o Boiling or irradiation have no effect and even routine autoclaving (at 1210C) is not reliable. Therefore, where there is a risk of exposure, surgeons use disposable instruments.o To sterilize reusable instruments, WHO currently recommends combined use of a strong solution of sodium hydroxide and extended autoclaving at 134degC."Autoclaving at 134{>C for 5 hrs or treatment with 2 N NaOH for several hours is recommended for sterilization ofprions ". -- Harrison', 'role': 'assistant'}]