This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of protein and amino acid, Subject name: Biochemistry
[{'content': 'Unfolded proteins are handled by \nSelect and explain. \nA. Chaperones, B. Histones, C. Proteases, D. Proteosomes', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Abnormal folding of proteins may lead to prion diseases. Chaperones help to produce the correct spatial arrangement. Chaperones attach to nascent polypeptide chains and prevent wrong foldings so that folding is allowed only in the correct direction.Ref: DM Vasudevan - Textbook of Biochemistry, 7th edition, page no: 604', 'role': 'assistant'}]