This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Nucleotides, Subject name: Biochemistry
[{'content': 'Inhibition of which of the following enzyme is responsible for the anticancer action of 5-Fluorouracil ? \nSelect and explain. \nA. Dihydrofolate reductase, B. Thymidylate kinase, C. Thymidylate reductase, D. Thymidylate synthase', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Drugs Inhibitor of 5-Fluorouracil thymidylate synthase(Suicidal inhibition) Methotrexate Dihydrofolate reductase Acyclovir thymidylate kinase', 'role': 'assistant'}]