This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Mediator of acute inflammation not derived from the cell is (D. REPEAT Feb 2014) \nSelect and explain. \nA. Histamine, B. Kinins, C. Leukotrienes, D. Cytokines', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Chemical Mediators of Inflammation\nAka permeability factors or endogenous mediators of increased vascular permeability.\nThey are broadly classified into 2 groups:\ni. Mediators released by cells.\nii. Mediators originating from plasma.\nChemical Mediators of Acute Inflammation\nA. Cell-Derived Mediators\n1. Vasoactive amines\n\nHistamine\n5-hydroxytryptamine\nNeuropeptides\n\n2. Arachidonic acid metabolites (Eicosanoids)\ni. Metabolites via cyclo-oxygenase pathway\n\nProstaglandins\nThromboxane A2\nProstacyclin\nResolvins\n\nii. Metabolites via lipo-oxygenase pathway\n\n5-HETE\nLeukotrienes\nLipoxins\n\n3. Lysosomal components (from PM Ns, macrophages)\n4. Platelet-activating factor (PAF)\n5. Cytokines\n\nIL-1\nTNF-α\nTNF-β\nIFN-γ\nChemokines\n\n6. Free radicals\n\nOxygen metabolites\nNitric oxide\n\nB. Plasma-Derived Mediators (Plasma Proteases) Products of:\n1. The Kinin system.\n2. The Clotting system.\n3. The Fibrinolytic system.\n4. The Complement system.', 'role': 'assistant'}]