This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Medicine
[{'content': 'Wolf Chaikoff effect- \nSelect and explain. \nA. Excess iodine intake causes hypothyroidism, B. Iodine induced hypehyroidism, C. Thyrotoxicosis due to excessive amount of iodine ingestion, D. Drug induced hypehyroidism', 'role': 'user'}, {'content': "Answer: A \nExplanation: Wolff-Chaikoff effect is a phenomenon in which excess iodide transiently inhibits thyroid iodide organification by thyroid peroxidase enzyme thus inhibiting thyroid hormone production leadung to hypothyroidism. In individuals with a normal thyroid, the gland escapes from this inhibitory effect and iodide organification resumes; the suppressive action of high iodide may persist, however, in patients with underlying autoimmune thyroid disease. Reference : page 2285 Harrison's Principles of Internal Medicine 19th edition", 'role': 'assistant'}]