This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Medicine
[{'content': 'Pheochromocytoma is associated with - \nSelect and explain. \nA. Vitiligo, B. Cafe-au-lait spots, C. Ash leaf amelanotic macusles, D. Acanthosis Nigricans', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e., Cafe-au-lait spots o About 25-33% of patients with a pheochromocytoma or paraganglioma have an inherited syndrome.# Neurofibromatosis type 1 (NF1) was the first described pheochromocytoma-associated syndrome.o The NF1 gene functions as a tumor suppressor by regulating the Ras signaling cascade. Classic features of neurofibromatosis include:# Multiple neurofibromas# Cafe au lait spots# Axillary freckling of the skin# Lisch nodules of the iris.o Pheochromocytomas occur in only about 1% of these patients and are located predominantly in the adrenals.", 'role': 'assistant'}]