This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Anaesthesia
[{'content': 'An ICU patient on atracurium infusion develops seizures after 2 days. The most probable cause is – \nSelect and explain. \nA. Accumulation of landonosine, B. Allergy to drug, C. Due to prolong infusion, D. All of the above', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Hofmann degradation of atracurium produces tertiary metabolite laudanosine which can cross blood brain barrier and produces convulsions.', 'role': 'assistant'}]