This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'The crescent formation is characteristic of the following glomerular disease - \nSelect and explain. \nA. Minimal change disease, B. Rapidly progressive glomerulonephritis, C. Focal and segmental glomerulosclerosis, D. Rapidly non progressive glomerulonephritis', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Regardless of the cause, the classical histological picture of RPGN is characterized by the presence of crescents in most of the glomeruli.\nSo, RPGN is also known as crescentic glomerulonephritis.\n\n\nCrescent formation\n\nDespite the wide variety of diseases that causes RPGN, all types of RPGN are characterized by glomerular injury and the formation of crescents.\nSevere injury and GBM rupture lead to the leakage of plasma proteins through the GBM.\nOf these proteins, fibrin is thought to contribute most strongly to the crescent formation.\nParietal epithelial cells lining the bowman capsule respond to the leaked fibrin and proliferate.\nInfiltrating white blood cells such as monocytes and macrophages also proliferate.\nThese proliferating cells surround and compress the glomerulus, forming a crescent-shaped scar that is readily visible on light microscopy of a renal biopsy.', 'role': 'assistant'}]