This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General physiology, Subject name: Physiology
[{'content': 'All of the following are true about Hepcidin except \nSelect and explain. \nA. It is a 25- amino acid peptide secreted by Kupffer cells, B. Decreases duodenal absorption of iron, C. It regulates activity of transpoers DMT - 1 and ferropoin - 1, D. Mice with enhanced hepcidin expression have elevate body iron stores', 'role': 'user'}, {'content': "Answer: D \nExplanation: Hepcidin, a 25-amino acid peptide secreted by hepatic Kupffer's cells downregulates duodenal iron absorption by regulating DMT1 activity as well as other proteins in the iron-responsive pathways (e.g., FP1). Hepcidin is a negative regulator of iron absorption because mice that fail to express hepcidin have elevated body iron stores, whereas mice with enhanced hepcidin expression have profound iron deficiency. .", 'role': 'assistant'}]