This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
[{'content': 'Non hormonal drug to prevent post menopausal osteoporosis is: \nSelect and explain. \nA. Alendronate, B. Estrogen, C. Raloxifene, D. Parathyroid', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Alenderonate, etidronate, pamidronate, and Ibandronate are bisphosphonates which inhibit bone resorption, and are very effective for both osteoporosis prevention and treatment.\nUses:\n• First line drugs for treating postmenopausal osteoporosis\n• Paget’s disease\n• Osteolytic bone metastasis.\nCaution: Patient should be instructed to take these drugs on an empty stomach with a large glass of water and then to remain upright for atleast 30 minutes as its major side effect is GI upset.\nRoute of administration: Oral or IV infusion\nNow lets have a look at other options:\n• Raloxifene: It is a selective estrogen receptor modulator which is also useful in management of osteoporosis but it is a hormonal preparation.\n• Parathyroid hormone: It is a novel therapy for osteoporosis. Unlike most of the treatments for osteoporosis that inhibit bone resorption, parathyroid hormone stimulates new bone formation. It is given by daily subcutaneous injection.\nAlso Know:\nOther non-hormonal drugs used for treatment of osteoporosis:\na. Calcium\nb. Vitamin D\nc. Calcitonin\nd. Slow releasing sodium fluoride.', 'role': 'assistant'}]