This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of lipid, Subject name: Biochemistry
[{'content': 'Familial hypercholesterolemia is due to defect in \nSelect and explain. \nA. Apo A, B. Lipoprotein lipase, C. Apo C, D. Apo B 100', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Name Defect Remarks Familial hypercholesterolemia (type IIa) Defective LDL receptors or mutation in the ligand region of apo B-100 Elevated LDL levels and hypercholesterolemia, resulting in atherosclerosis and coronary disease Reference: Harper; 30th edition; Page no: 275', 'role': 'assistant'}]