This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Murmurs, Subject name: Medicine
[{'content': "A 75-year-old man presents to his GP for a routine check-up. On examination the GP hears a high-pitched diastolic murmur, heard loudest at the right sternal edge and on expiration. Given the likely diagnosis, which of the following is NOT a risk factor for this condition? \nSelect and explain. \nA. Ankylosing spondylitis, B. Marfan's syndrome, C. Holt Oram Syndrome, D. Infective endocarditis", 'role': 'user'}, {'content': 'Answer: C \nExplanation: Aoic regurgitation, High pitched diastolic murmur heard in case of AR Best heard on the left side. Option A: MC cardiovascular disease in Ankylosing spondylitis =A.R. Option B: Marfan syndrome is a Risk factor. Option C: ASD+ skeletal defects/Absent radius bone - Holt Oram Syndrome = In ASD shunt murmur is absent, in ASD it is flow murmur | Mid diastolic murmur Option D: Inf. endocarditis- bacteria will invade the valve leaflet & will contribute to developing Diastolic Murmur.', 'role': 'assistant'}]