This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of Purines and Pyrimidines, Subject name: Biochemistry
[{'content': 'Deficiency of purine nucleoside phosphorylase causes - \nSelect and explain. \nA. Complement deficiency, B. Cellular immunodeficiency, C. Humoral immunodeficiency, D. Combined immunodeficiency', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e., Cellular immunodeficiency o Purine nucleoside phosphorvlase is involved in purine nucleoside catabolism.o Purine nucleoside phosphorylase (PNP) deficiency is an autosomal recessive disorder,o It is characterized by decreased cell mediated immunity and recurrent infection,o There is a severe T-cell deficiency with normal B-cel! function.o They usually present with hypoplastic anemia with recurrent pneumonia, diarrhea and candidiasis.Also knowo Adenosine deaminase deficiency causes severe combined immunodeficiency.", 'role': 'assistant'}]