This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Physiological Changes of Pregnancy, Subject name: Gynaecology & Obstetrics
[{'content': 'At any given point during the pregnancy, AFP levels are highest in: \nSelect and explain. \nA. Fetal serum, B. Placenta, C. Amniotic fluid, D. Maternal serum', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Alpha Fetoprotein in the fetal serum is the highest. It is 1000 times more than maternal serum. AFP levels are increased in omphalocele, gastroschisis, NTDs, Anencephaly. AFP are low in trisomy, trophoblastic diseases, maternal obesity, overestimated gestational age, intrauterine death', 'role': 'assistant'}]