This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'In a patient with nephrotic syndrome and hypoalbuminemia, protein binding of which drug will not be affected: \nSelect and explain. \nA. Tolbutamide, B. Morphine, C. Diazepam, D. Valproate', 'role': 'user'}, {'content': 'Answer: B \nExplanation: - In the given options, only Morphine has less plasma protein binding (35%), whereas all others are highly plasma protein bound (>90%).\n- In nephrotic syndrome, there will be protein loss resulting in hypoalbuminemia. So less plasma proteins.', 'role': 'assistant'}]