This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
[{'content': "All are true regarding Crohn's disease except: \nSelect and explain. \nA. Infertility, B. Risk of Ca, C. Medical treatment includes antibiotics, probiotics and TNF alpha blockers, D. ASCA-negative", 'role': 'user'}, {'content': "Answer: D \nExplanation: Ref: Harrison s Principles of Internal Medicine, 18th edition, pg 2486 Explanation: Crohn's disease- MC site-terminal ileum with rectal sparing, skip areas + It is transmural, hence more of fistula formation More of systemic symptoms, pain, abdominal mass Toxic megacolon - Perforation Intraabdominal abscess, fallopian tube scarring - infertility Intestinal obstruction, massive hemorrhage, malabsorption, severe perianal disease Cobblestoning on endoscope Response to antibiotics and recurrence after surgery ASCA(anti-saccharomyces cerevisiae antibody)-positive Treatment - Antibiotics, corticosteroids, sulfasalazine, mercaptopurine, azathioprine, methotrexate. cyclosporine, tacrolimus Anti-TNF: Infliximab, adalimumab. certolizumab pegol Anti-integrin: Natalizumab Risk of Ca increases with duration & severity of the disease (See the following table)", 'role': 'assistant'}]