This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pancreas, Subject name: Pharmacology
[{'content': 'Which of the following are the adverse effects of pioglitazone? \nSelect and explain. \nA. Weight gain, B. Hepatotoxicity, C. Increased risk of urinary bladder cancer, D. All of the above', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Glitazones - They act by stimulating PPAR- g receptor - Reverse insulin resistance - e.g. Pioglitazone Pioglitazone: -Adverse effects: Hepatotoxic Sodium and water retention weight gain Increases risk of urinary bladder carcinoma Avoid in liver disease or hea failure -Rosiglitazone increases the risk of myocardial infarction -Troglitazone banned because it cause liver damage', 'role': 'assistant'}]