This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Menadione (Vitamin K3) \nSelect and explain. \nA. Can cause hemolysis in a patient with G-6-PD deficiency, B. Is the preparation of choice to antagonize the effect of warfarin overdose, C. Is useful to prevent hemorrhagic disease of the newborn, D. Is given in large doses in patients with severe liver disease', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Menadione is fat-soluble synthetic vitamin K3. It can cause hemolysis in G-6-PD deficient individuals. In severe hepatic disease, large doses of menadione can further depress liver function. Menadione is not used to prevent haemorrhagic disease of the newborn as it can cause kernicterus, instead phytonadione is used. Phytonadione is also the drug of choice to overcome the toxic effects of warfarin as it acts rapidly.', 'role': 'assistant'}]