This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'Oxidative decarboxylation of pyruvate requires \nSelect and explain. \nA. NADP+, B. Cytochromes, C. pyridoxal phosphate, D. COASH', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Inside the mitochondria, pyruvate is oxidatively decarboxylated to acetyl CoA by pyruvate dehydrogenase (PDH). It is a multi-enzyme complex with 5 co-enzymes and 3 apo-enzymes.\nThe co-enzymes needed are:\n\nThiamine pyrophosphate (TPP)\nCo-enzyme A (CoA)\nFAD\nNAD+\nLipoamide.\nThe enzyme part of the PDH complex is made up of three component enzymes.\n\nReference: Vasudevan 7th\xa0 ed, pg 116', 'role': 'assistant'}]