This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Pharmacology
[{'content': 'At equally natriuretic doses, which of the following drugs causes maximum potassium excretion? \nSelect and explain. \nA. Spironolactone, B. Furosemide, C. Acetazolamide, D. Aldosterone', 'role': 'user'}, {'content': 'Answer: C \nExplanation: CA inhibitors like acetazolamide decrease the secretion of H+ in the distal tubules and collecting ducts. Due to less reabsorption of sodium in the PCT, more is delivered to the distal tubules (DT). Na+ is exchanged with K+ and H+. At equally natriuretic doses, K+ excretion is maximum with CA inhibitors because Na+ delivered to the distal tubules is exchanged only with K+ (excretion of H+ is inhibited by these drugs).', 'role': 'assistant'}]