This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General Concepts, Subject name: Pathology
[{'content': 'Which of the following is not true about epithelial-mesenchmyal transition (EMT)? \nSelect and explain. \nA. Controlled by the transcription factors SNAIL and TWIST, B. Upregulation of E-cadherin expression, C. Integral to the metastasis of carcinomas, D. Homotypic intercellular adhesion is lost', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Dissociation of cancer cells from one another is often the result of alterations in intercellular adhesion molecules and is the first step in the process of invasion. E-cadherins are transmembrane glycoproteins that mediate the homotypic adhesion of epithelial cells, holding them together. In many epithelial cancers it is hypothesized that E-cadherin expression is silenced, at least transiently, through a process called epithelial-mesenchymal transition (EMT). Postulated that EMT is integral to the metastasis of carcinomas, paicularly breast and prostate cancers EMT is controlled by the transcription factors SNAIL and TWIST Downregulation of epithelial markers (e.g., E-cadherin) Concomitant upregulation of mesenchymal markers (e.g., vimentin and smooth muscle actin)', 'role': 'assistant'}]