This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': "An infant has hepatosplenomegaly, hypoglycemia, hyperlipidemia, acidosis and normally structured glycogen deposition in the liver. What is the diagnosis – \nSelect and explain. \nA. Her's disease, B. Von Gierke's disease, C. Cor's disease, D. Anderson's disease", 'role': 'user'}, {'content': 'Answer: B \nExplanation: Von-Gierke disease (Type I glycogenosis)\n\nIt is an autosomal recessive disorder.\nIt is due to absent or deficient activity of glucose-6-phosphatase in\xa0Liver, Kidney, Intestinal mucosa\nIt can be divided into two subtypes -\nType la →\xa0glucose - 6 - phosphatase is defective\nType lb → \xa0Translocase is defective (translocase transports glucose-6-phosphatase across the microsomal membrane).\n\nClinical features\n\nHypoglycemia\nSeizures\nDoll-like faces with fat cheeks\xa0\nThin extremities\nShort Stature\nProtrubent abdomen\nHepatomegaly and renontegaly\nNormal spleen & heart size\n\nBiochemical findings\n\nHypoglycemia\nHyperuricemia\nHyperlipidemia\nLactic acidosis', 'role': 'assistant'}]