This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: miscellaneous, Subject name: Biochemistry
[{'content': 'In sickle cell anaemia, sickle shapes occur due to polymerization of \nSelect and explain. \nA. Oxyhemoglobin, B. Deoxyhemoglobin, C. Methoxyglobin, D. Cyanohemoglobin', 'role': 'user'}, {'content': 'Answer: B \nExplanation: The substitution of hydrophilic glutamic acid by hydrophobic valine causes a localized stickiness on the surface of the molecule. The deoxygenated HbS may be depicted with a protrusion on one side and a cavity on the other side, so that many molecules can adhere and polymerize.Ref: D M Vasudevan 7th edition Page no: 291,292', 'role': 'assistant'}]