This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: DNB 2018, Subject name: Pharmacology
[{'content': 'The mechanism of action of cyclosporine is: \nSelect and explain. \nA. Inhibits IL-2 receptors, B. Inhibits TNF alpha, C. Decrease in transcription of IL-2 gene, D. Targets inactivated T cells', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Cyclosporine calcineurin inhibitor inhibits the dephosphorylation of NFAT leading to blocked of T cell activation by preventing IL2 Transcription. Tacrolimus (FK506):- is also calcineurin inhibitor which binds FK506 binding protein. IL2 receptor are blocked by Basiliximab, Daclizumab. TNF alphaBlocker :- Infliximab', 'role': 'assistant'}]