This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autacoids, Subject name: Pharmacology
[{'content': 'A patient on aspirin will have an increase in: \nSelect and explain. \nA. Bleeding time, B. Clotting time, C. Prothrombin time, D. Activated paial thromboplastin time', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Aspirin, even in small doses, irreversibly inhibits TXA2 synthesis by platelets. Thus, it interferes with platelet aggregation and bleeding time is prolonged to nearly twice the normal value. long-term intake of large dose decreases the synthesis of clotting factors in the liver and predisposes to bleeding; can be prevented by prophylactic vit K therapy. ESSENTIALS OF MEDICAL PHARMACOLOGY;7TH EDITION; KD TRIPATHI; PAGE NO 196', 'role': 'assistant'}]