This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Investigation of choice to confirm sickle cell disease \nSelect and explain. \nA. Tandem mass spechrometry, B. Gel Electrophoresis, C. High performance liquid chromatography, D. Naked eye single Tube Red Cell Osmotic Fragility test', 'role': 'user'}, {'content': 'Answer: C \nExplanation: HPLC is the investigation of choice to confirm the diagnosis of sickle cell anemia.', 'role': 'assistant'}]