This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Complement-mediated lysis is mediated by - \nSelect and explain. \nA. IgM, B. IgE, C. IgA, D. IgD', 'role': 'user'}, {'content': 'Answer: A \nExplanation: The classical activation pathway activated by antigen/antibody immune complexes. Antigen involved is\xa0IgM or IgG\nOther pathways of the complement system\na) The mannose-binding lectin activation pathway activated by microbes with mannose terminal\xa0groups.\nb) The alternative activation pathway activated by microbes or tumor cells.\nc) The terminal pathway that is common to first three pathways and leads to the membrane attack\xa0complex that lyses cells.', 'role': 'assistant'}]