This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti Microbial, Subject name: Pharmacology
[{'content': 'Anti TB drug causing optic neuritis: \nSelect and explain. \nA. Isoniazid, B. Rifampicin, C. Pyrazinamide, D. Ethambutol', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ref: KDT 6th ed. pg. 742* Side effect of Ethambutol: Loss of visual acuity/colour vision, field defects due to optic neuritis is the most important dose and duration of therapy dependent toxicity.* Important side effects of antitubercular drugs:* Peripheral neuropathy (due to vit B6 deficiency): ISONIAZID* Orange color urine-RIFAMPICIN* Flu-like symptoms- RIFAMPICIN* Hyperuricemia/gout- PYRAZINAMIDE* Optic neuritis- ETHAMBUTOL* Nephrotoxic, Ototoxic, Neuromuscular Junction Blocker- STREPTOMYCINOther important points to remember about Anti TB drugs:* First line anti TB drugs are: HRZE (Isoniazid, Rifampicin, Pyrazinamide, Ethambutol)* All first line drugs are bactericidal EXCEPT- Ethambutol (it is bacteriostatic)* Most hepatotoxic ATT-Pyrazinamide* 1st line ATT with exclusive intracellular action-Pyrazinamide* 1st line ATT with exclusive extracellular action-Streptomycin* Which anti TB drugs are NOT hepatotoxic-Ethambutol and Streptomycin.* It should not be used in children below 6 years of age because these young patients may not be able to report visual impairment.', 'role': 'assistant'}]