This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Which of the following statements is wrong \nSelect and explain. \nA. Drugs should be highly lipid soluble to be administered transdermally, B. Nitrates are given by sublingual route, C. Intra arterial injection is a systemic route of drug administration, D. Parenteral route bypasses 1st metabolism', 'role': 'user'}, {'content': 'Answer: C \nExplanation: None', 'role': 'assistant'}]