This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'Which of the following does not cross the cell membrane : \nSelect and explain. \nA. Glucose-6-phosphate, B. Glucose, C. Nitrous oxide, D. Carbon monoxide', 'role': 'user'}, {'content': 'Answer: A \nExplanation: A i.e. Glucose-6-phosphate Glucose-6-phosphate cannot cross the cell membrane unless it in conveed into Glucose by the enzyme - Glucose-6-phosphatase.QVon Gerkes disease in deficiency of Glucose-6-phosphatase leads to accumulation of glucose-6-phosphate (and hence glycogen in the liver). In the absence of this enzyme, glucose-6-phosphate is not conveed into glucose and thus cannot enter the blood leading to hypoglycemia.', 'role': 'assistant'}]