This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Lipoproteins, Subject name: Biochemistry
[{'content': 'Familial hypercholesterolemia is \nSelect and explain. \nA. Deficient LDL receptors, B. Deficient HDL receptors, C. HMG CoA reductase deficiency, D. Deficient VLDL receptors', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Familial Hypercholesterolemia, or Type IIa hyperlipoproteinemia is defect in LDL-receptors or defect in Apo B100 apoprotein. In this disease, LDL levels & cholesterol is raised in blood. It is Autosomal dominant (AD). ADDITIONAL INFORMATION ON HYPERLIPOPROTEINEMIA: Type Defect Lipoprotein increased TGs Cholesterol Name I Lipoprotein Lipase or Apo C- II Chylomicron || VLDL | || Normal Familial Hyperchylomicronemia (AR) IIa LDL - receptor or Apo B100 LDL|| Normal || Familial Hypercholesterolemia IIb Unknown VLDL| LDL| | | Familial combined Hyperlipoproteinemia (AR) III Apo E Chylomicron Remanant || VLDL remnant | || || Dysbeta - lipoproteinemia or Broad - Beta disease (AR)', 'role': 'assistant'}]