This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Eculizumab is used in treatment of: \nSelect and explain. \nA. Acne vulgaris, B. Asthma, C. Paroxysmal nocturnal hemoglobinuria, D. Autoimmune haemolytic anemia', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Eculizumab is a humanized IgG monoclonal antibody that binds the C5 complement component, inhibiting its cleavage into C5a and C5b thereby inhibiting the terminal pore-forming lytic activity of complement. Eculizumab is approved for patients with paroxysmal nocturnal hemoglobinuria (PNH) and dramatically reduces the need for red blood cell transfusions. Ref: Katzung 11th edition Chapter 61.', 'role': 'assistant'}]