This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Regarding oncogenesis: All are true except: \nSelect and explain. \nA. Topoisomerase II causes breaks in strands, B. p53 is the most common oncogene mutation causing malignancy in humans, C. At G2-M phase there is loss of inhibitors controlling cell-cycle, D. Decrease in telomerase activity causes anti-tumor effects', 'role': 'user'}, {'content': 'Answer: B \nExplanation: None', 'role': 'assistant'}]