This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunology and Rheumatology, Subject name: Medicine
[{'content': 'A young woman with ataxia-telangiectasia syndrome.For each patient with a medical condition, select the most likely immune dysfunction. \nSelect and explain. \nA. B-cell deficiency/dysfunction, B. mixed T- and B-cell deficiency/dysfunction, C. T-lymphocyte deficiency/dysfunction, D. neutropenia', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ataxia-telangiectasia and both T- and B-cell dysfunction.Multiple myeloma and chronic lymphocytic leukemia are two of the more common causes of B-cell deficiency/dysfunction. Hodgkin's disease, AIDS, sarcoidosis, and thymic aplasia or hypoplasia result in T-lymphocyte depletion/dysfunction. SLE has been associated with C3 deficiency, but most severe complement deficiencies result from inherited disorders. Ataxia telangiectasia, common variable hypogammaglobulinemia, severe combined immunodeficiency, and Wiskott-Aldrich syndrome have mixed T- and B-cell deficiency.", 'role': 'assistant'}]