This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'What happens to hepcidin levels in Anemia of chronic disease \nSelect and explain. \nA. Increases, B. Decreases, C. Remains normal, D. Any of the above', 'role': 'user'}, {'content': 'Answer: A \nExplanation: In anemia of chronic disease due to release of cytokines IL-6, TNF-α, IL - 1, (as a result of chronic inflammation) hepcidin synthesis increases in the liver.\nHepicidin inhibits iron release from macrophages.', 'role': 'assistant'}]