This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Nutrition, Subject name: Pediatrics
[{'content': 'Most common cause of congenital hypothyroidism in \nSelect and explain. \nA. Antithyroid drugs, B. Thyroid dysgenesis, C. Defective hormone synthesis, D. Excessive iodine consumption', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Congenital hypothyroidism:- The disorder encompasses a spectrum ranging from complete agenesis, paial agenesis to ectopic thyroid. Iodine deficiency is the commonest cause in endemic pas and thyroid dysgenesis is the most common etiology in non endemic areas. Clinical manifestations include hoarse cry, facial puffiness, umbilical hernia, hypotonia, mottling of skin and lethargy. Prolonged jaundice, constipation, and unexplained hypothermia may also indicate hypothyroidism. Open posterior fontanelle is an impoant indicator. History of maternal thyroid disease or ingestion of antithyroid medications enquired. Reference: GHAI essential Paediatrics', 'role': 'assistant'}]