This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Medicine
[{'content': 'Type 1 diabetes mellitus is associated with- \nSelect and explain. \nA. Male gender, B. Old age, C. Gestational diabetes, D. HLADR3', 'role': 'user'}, {'content': "Answer: D \nExplanation: Type 1 DM is the result of interactions of genetic, environmental, and immunologic factors that ultimately lead to T-cell mediated autoimmune destruction of the pancreatic beta cells and insulin deficiency. Type 1 DM, which can develop at any age, develops most commonly before 20 years of age. Most individuals with type 1 DM have the HLA DR3 and/or DR4 haplotype. There is little or no sex bias within either Type I (insulin-dependent)(although most autoimmune diseases dispropoionately affect females) or Type II (non-insulin-dependent) diabetes mellitus. Reference : page 2403 Harrison's Principles of Internal Medicine 19th edition", 'role': 'assistant'}]