This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Misc. (W.B.C), Subject name: Pathology
[{'content': 'In patients with Chronic Myeloid Leukemia \nSelect and explain. \nA. ABL gene on Chr. 22 is trans-located to BCR gene on Chr.9, B. The fusion gene bcr-abl forms a protein with tyrosine kinase activity, C. Splenomegaly is unusual, D. Philadelphia chromosome positive patients respond poorly to Imatinib', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Ans. (b) The fusion gene bcr-abl forms a protein with tyrosine kinase activity(Ref: Robbins 9th/pg 616-618)a. FALSE, as ABL gene is on chr9q while BCR is on chr22qb. The fusion gene bcr-abl forms a protein with tyrosine kinase activity: TRUEc. FALSE; Massive splenomegaly is a feature of CMLd. FALSE; as response to Imatinib is good in patients with Philadelphia chromosome +ve', 'role': 'assistant'}]