This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'Niemann-pick disease is due to the disturbance in: \nSelect and explain. \nA. Lipid metabolism, B. Protein metabolism, C. Carbohydrate metabolism, D. Mineral metabolism', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Progressive lysosomal accumulation of glycosphingolipids\xa0in the central nervous system leads to neurodegeneration,\xa0storage\xa0in\xa0visceral\xa0cells\xa0can\xa0lead\xa0to\xa0organomegaly,\xa0skeletal abnormalities, pulmonary infiltration, and other\xa0manifestations. Such diseases are due to defect in lipid metabolism.', 'role': 'assistant'}]