This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Mechanism of action of paclitaxel is ? \nSelect and explain. \nA. Topoisomerase inhibition, B. Increase the polymerization of tubulin, C. Inhibition of protein synthesis, D. Alkylation of DNA', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e., Increase the polymerization of tubulin Taxanes Paclitaxel and docetaxel function as a mitotic spindle poison through high affinity binding to microtubules with enhancement of tubulin polymerization. The microtubules are stabilized and their depolymerization is prevented - inhibition of mitosis and cell division. Paclitaxel is metabolized in liver and undergoes enterohepatic circulation - dose should be reduced in liver dysfunction. Paclitaxel can cause hypersensivity reaction which does not occur with a novel albumin-bound paclitaxel preparation. Paclitaxel and docetaxel both can cause bone marrow depression & peripheral neuropathy.", 'role': 'assistant'}]