This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: JIPMER 2017, Subject name: Pharmacology
[{'content': 'Warfarin induced skin necrosis is seen in: \nSelect and explain. \nA. Protein C deficiency, B. Sickle cell anemia, C. Factor V leiden deficiency, D. Antithrombin 3 deficiency', 'role': 'user'}, {'content': 'Answer: A \nExplanation: It is due to decreased levels of protein C. It is more likely to occur in patients with genetic deficiency of protein C. Most common side effect of warfarin:Bleeding Dermal vascular necrosis is early appearing adverse effect. Due to decreased osteocalcin synthesis Warfarin causes nasal hypoplasia and therefore contraindicated in pregnancy', 'role': 'assistant'}]