This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
[{'content': 'Marfan disease \nSelect and explain. \nA. Collagen I, B. Collagen IV, C. Fibrillin I, D. Fibrillin II', 'role': 'user'}, {'content': 'Answer: C \nExplanation: In Marfan syndrome, a connective tissue disorder of autosomal dominant inheritance, the basic biochemical abnormality is a mutation affecting fibrillin. Mutations in the FBN1 gene are found in all patients with Marfan syndrome. Clinical features may include tall stature, long fingers, bilateral subluxation of lens, mitral valve prolapse, aoic aneurysm, and aoic dissection (Robbins Basic Pathology,9th edition,pg no. 221)', 'role': 'assistant'}]