This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pharmacology
[{'content': 'Which one has least mineralocoicoid activity? \nSelect and explain. \nA. Coisol, B. Prednisolone, C. Fludrocoisone, D. Methyl prednisolone', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Coisol (Hydrocoisone) has primary glucocoicoid action and has significant mineralocoicoid activity. Prednisolone has glucocoicoid activity but at high doses fluid retention does occur. Fludrocoisone is a potent mineralocoicoid having very less glucocoicoid activity. Methylprednisolone is more selective glucocoicoid with very less mineralocoicoid activity (REF.Essential of medical pharmacology K D TRIPATHI 6 Edition - Page No - 281)', 'role': 'assistant'}]