This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Major source of Von willebrand factor (vWF) ? \nSelect and explain. \nA. Erythrocytes, B. Neutrophils, C. Endothelial cells, D. Monocytes', 'role': 'user'}, {'content': "Answer: C \nExplanation: Ans. is 'c' i.e., Endothelial cells o Circulating factor VIII has two components. (a) Factor VIIIc (Procoagulant protein) o This is the smaller component o It is synthesized in liver (main source) and kidney. It is an intrinsic pathway component required for activation of factor X. (b) Von willebrand factor (vWF) o This is the larger component It is produced by endothelial cells (main source) and megakaryocytes. o It has two major functions. (i) Helps in platelet adhesion by interacting platelet membrane glycoprotein lb-IX. (ii) Stabilizes factor VIIIc.", 'role': 'assistant'}]