This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General Pharmacology, Subject name: Pharmacology
[{'content': 'Loading of dose of a drug primarily depends on: \nSelect and explain. \nA. Volume of distribution, B. Clearance, C. Rate of administration, D. Half life', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. A. Volume of distributionLoading dose is dependent on volume of distribution; whereas maintenance dose depends on the clearance.Loading doseMaintenance dose* It is the initial high dose which is given to achieve the desired plasma concentration after saturating (loading) the tissue binding sites.* Just enough drug is given in each dose to replace the drug eliminated* When time to reach steady state is long, as it is for drugs with long half-lives, it is desirable to give a loading dose that promptly raises the concentration of drug in plasma * LD=Vdx Desired plasma concentration (mg/L)* MD = Clearance x Desired plasma concentration (mg/L)', 'role': 'assistant'}]