This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Clinical Presentation and Physiology, Subject name: Surgery
[{'content': "Peau d'orange in carcinoma breast is due to:(AIIMS November 2015, DNB 2012, PGI June 95, December 95) \nSelect and explain. \nA. Obstruction of sub-dermal lymphatics, B. Infiltration of Coopers ligament, C. Hematogenous dissemination, D. Nipple involvement", 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. a. Obstruction of suh-dermal lymphatics (Ref: Bailey 26/e p811, 25/e p840)Peau-d-orange is due to cutaneous lymphatic edema, caused by obstruction of subdermal lymphatics.Peau-d-orangePeau-d-orange is due to cutaneous lymphatic edema, where the infiltrated skin is tethered by sweat ducts, it can not swell, leading to an appearance like orange skinQ.Due to obstruction of subdermal lymphatics (lymphatic permeation by tumor cellsQ)Seen in advanced breast cancerQ (may be seen in chronic abscessQ)', 'role': 'assistant'}]