This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': 'Acetaminophen poisoning causes which of the following changes in the liver? \nSelect and explain. \nA. Centrilobular necrosis in liver, B. Microvesicular fatty infiltration in hepatocytes, C. Cholestasis, D. Peripoal inflammation', 'role': 'user'}, {'content': "Answer: A \nExplanation: Acetaminophen poisoning typically causes centrilobular necrosis in liver. Ref: Harrison's Principles of Internal Medicine, 18th Edition, Page 2560, see Table: 305-1.", 'role': 'assistant'}]