This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Growth and development, Subject name: Pediatrics
[{'content': 'Earliest sign of rickets is __________ \nSelect and explain. \nA. Craniotabes, B. Harrisons groove, C. Rachitic rosary, D. Pigeon breast', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Most manifestations of rickets are a result of skeletal changes , Craniotabes is a softening of the cranial bones and can be detected by applying pressure at the occiput or over the parietal bones. T he sensation is similar to the feel of pressing into a ping-pong ball and then releasing. Craniotabes may also be secondary to osteogenesis imperfecta, hydrocephalus, and syphilis. Ref.nelson 20th edition page 339 nutrition chapter', 'role': 'assistant'}]