This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
[{'content': 'Glucoseramide with enlarged liver and spleen is found in - \nSelect and explain. \nA. Gaucher, B. Tay sachs, C. Fabry, D. Niemanpick', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is Gaucher Gaucher's o Autosomal recessive, o Deficiency of glucocerebrosidase. o Accumulation of glucosyl ceramides in cells of RES. o Spleen enlarged with S/o hypersplenism (leukopenia thrombocytopenia), o Liver enlarged, o Expansion of bone marrow. Tay sachs o Autosomal recessive, o Deficiency of hexosaminidase, o Accumulation of ganglioside GM2 in nervous system, o C/F Apathy Hypotomia Visual defect Develop mental defect o Fundus = Cherry red spot hepatosklema o Fabry o X-link recessive. o Dificiency of ceramide trihexosidase. o Accumulation of trihexose in CNS, skin, kidney. Blood vessel, heart, sweat, comea'bone marrow, o Recurrent episodes of burning pain and paresthesia, o Skin lesion, o Corneal opacity cataract, o Necrosis of femoral head, o Hyperkalemia. o Renal failure, hepatospleno megaly o.", 'role': 'assistant'}]