This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'First antibody to appear in plasma/blood in acute hepatitis B is? \nSelect and explain. \nA. Ig M Anti HBc, B. Ig M Anti HBc, C. Anti HBs, D. Anti HBe', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ig M Anti HBc REF: Harrison\'s 17ed chapter 298, markers See APPENDIX-28 for "MARKERS OF HEPATITIS-B"', 'role': 'assistant'}]