This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NEET 2019, Subject name: Pharmacology
[{'content': 'Which of the following statement is true regarding fixed dose combination of drugs? \nSelect and explain. \nA. Adverse effect of one drug may be reduced by the other drug, B. Two drugs with different pharmacokinetics can be combined easily, C. Dose of one drug can be altered independently as per requirement, D. Adverse effect can be ascribed to a single drug', 'role': 'user'}, {'content': "Answer: A \nExplanation: Fixed dose combination (FDC):- Combination of two or more active drugs in single dose form. Rationality of FDC's should be based on ceain aspect such as:- The drugs in combination should act by different mechanism. Pharmacokinetic must not be widely different. Combination should not have supraadditive toxicity of the ingredients. Demerits:- Dosage alteration of one drug is not possible without alteration of other drugs. Differing pharmacokinetic of constituent drugs poses the problem of frequency of administration of the formula. Increased chance of adverse drug effect and interaction compared with both drugs given individually.", 'role': 'assistant'}]