This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Neuroradiology, Subject name: Radiology
[{'content': 'Tigroid white matter on MRI is seen in? \nSelect and explain. \nA. Pantothenate kinase deficiency, B. Pelizaeus-merzbacher disease, C. Neuroferritinopathy, D. Aceruloplasminemia', 'role': 'user'}, {'content': 'Answer: B \nExplanation: The tigroid pattern/ leopard skin sign occurs on MRI head is seen in Pelizaeus-merzbacher disease, due to creation of islands of perivascular myelin due patchy myelin deficiency. It is a rare hypomyelination syndrome caused by mutation in proteolipid protein, PLP 1 gene at chromosome Xq22. Child will show slow psychomotor development with nystagmus(pendular eye movements), hypotonia, extrapyramidal symptoms and spasticity. Tigroid pattern is also seen in metachromatic leucodystrophy.', 'role': 'assistant'}]