This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: ENT
[{'content': 'All statement about Plummer–Vinson syndrome are true except - \nSelect and explain. \nA. Commonly leads to carcinoma in lower third of esophagus, B. Common with iron deficiency, C. Common in females, D. Premalignant', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Plummer-Vinson syndrome\n\nPlummer-Vinson syndrome, also known as Brown-Kelly-Paterson syndrome or sideropenic dysphagia, seen in middle-aged edentulous women.\nThe plummer Vision Paterson Brown-Kelly Syndrome is characterized by : -\n\n\nDysphagia\nChronic iron deficiency anaemia\nAtrophic oral mucosa and glossitis\nBrittle, spoon-shaped fingernails (Koilonychia)\n\n\nThe cause of dysphagia is usually a cervical esophageal web, but abnormal pharyngeal and esophageal motility may play a role.\nThe syndrome characteristically occurs in middle-aged edentulous (without teeth) women.\nIt is a premalignant lesion. Approximately 10% of patient develop squamous cell Ca of esophagus, oral cavity or the hypopharynx.\nAs iron-deficiency anemia is a common finding, it is also known as sideropenic dysphagia.\nCarcinoma develops in the postcricoid region (not in the lower third oesophagus).', 'role': 'assistant'}]