This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Enzymes, Subject name: Biochemistry
[{'content': 'Activity of which of the following enzyme increase in alcoholism? \nSelect and explain. \nA. Lactate dehydrogenase, B. Acid phosphatase, C. Alkaline phosphatase, D. Gamma-glutamyltransferase', 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans. d (Gamma-glutamyItransferase). (Ref. Harper's Biochemistry 26th ed. 212)# Increased hepatic gamma-glutamyltransferase (GGT) activity following chronic ethanol consumption has been attributed to enzyme induction, dietary carbohydrate imbalance, and/or to hepatic cell damage.# It is suggested that cellular damage following increased lipid accumulation, depletion of hepatic glutathione, or changes in biliary flow may be associated with the increased GGT activity.", 'role': 'assistant'}]