This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Which of the following lipid lowering drug acts by inhibiting HMG-CoA reductase: March 2008, 2010 \nSelect and explain. \nA. Resins, B. Statins, C. Fibric acid deravatives, D. Bile acid sequestrants', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Ans. B: Statins Statins act by competitively inhibiting HMG-CoA reductase, the first committed enzyme of the HMG-CoA reductase pathway. Because statins are similar to HMG-CoA on a molecular level they take the place of HMG-CoA in the enzyme and reduce the rate by which it is able to produce mevalonate, the next molecule in the cascade that eventually produces cholesterol, as well as a number of other compounds.', 'role': 'assistant'}]