This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: DNB 2018, Subject name: Pharmacology
[{'content': 'Which of the following drug is specifically for Her 2 positive breast carcinoma is: \nSelect and explain. \nA. Trastuzumab, B. Tamoxifen, C. Exemestane, D. Fulvestrant', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Monoclonal antibody against HER2/neu receptor are:- Trastuzumab Peuzumab S/E:- Cardiotoxic Tamoxifen:- Antagonist on estrogen receptor expressed in mammary tissue. - Agonist on estrogen receptor in bone - Useful not only in treatment and prophylaxis of breast cancer but also in prevention of osteoporosis Exemestane:- a steroid molecule, irreversible inhibitor of aromatase(enzyme required for estrogen synthesis) Fulvestrant:- Pure estrogen receptor antagonist(Selective estrogen receptor down regulator)', 'role': 'assistant'}]