This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Molecular Genetics, Subject name: Biochemistry
[{'content': 'The gene frequency for an X-linked recessive disease is 1 in 1,000 in the general population. What is the frequency of affected males in this population? \nSelect and explain. \nA. 1 in 10, B. 1 in 100, C. 1 in 500, D. 1 in 1,000', 'role': 'user'}, {'content': 'Answer: D \nExplanation: If the disease frequency in the population is 1 in 1,000, and the disorder is X linked, that means that out of 1,000 men, 1 would have the disease because each man contains one X chromosome. Because women contain two X chromosomes, the carrier frequency is 1 in 500 because 500 women would contain 1,000 X chromosomes, one of which would contain the mutated allele.', 'role': 'assistant'}]