This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.N.S, Subject name: Pharmacology
[{'content': 'Which of the following extrapyramidal effect is seen on chronic use of antipsychotic - \nSelect and explain. \nA. Dystonia, B. Akathisia, C. Tardive dyskinesia, D. Parkinsonism', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ans. is \'c\' i.e., Tardive dyskinesia Neurological side effects of Neuroleptic DrugsReactionFeaturesTime of Maximal RiskProposed MechanismTreatmentAcute dystoniaSpasm of muscles of tongue, face, neck, back, may mimic sei- zures; not hysteria1 to 5 daysUnknownAntiparkinsonian ages are diagnostic and curativeAkathisiaMotor restlessness; not anxiety or "agitation"5 to 60 daysUnknownReduce dose or change drug; antiparkinsonian agents, benzodiazepines or propranolol may helpParkinsonismBradykinesia, rigidity, variable tremor, mask facies, shuffling gait5 to 30 days; can recur even after a single doseAntagonism of dopamineAntiparkinsonian agents helpfulNeuroleptic malignant syndromeCatatonia, stupor, fever unstable blood pressure myoglobinemia; can be fatalWeeks; can persist for days after stopping neuro- lepticAntagonism of dopamine may contri- buteStop neuroleptic immediately; dantrolene or bromocriptine may help; antiparkinsonism agents not effectivePerioral tremor "rabbit syndrome"Perioral tremor (may be a late variant of parkin- sonism)After months or years of treatmentUnknownAntiparkinsonian agents often helpTardive dyskinesiaOral-facial dyskinesia; widespread choreo- athetosis or dystoniaAfter months or years of treatment (worse on withdrawal)Excess function of dopamine hypothesizedPrevention crucial; treat- ment unsatisfactory', 'role': 'assistant'}]