This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Long term use of nitrates lead to decreased effect because of - \nSelect and explain. \nA. Development of resistance, B. SH group in the enzyme, C. Decreased oral absorption, D. Increased resistance', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Ans. is \'b\' i.e., SH groups in the enzyme o Tolerance develops to hemodynamic and antiischaemic effects of nitrates if they are continuously present in the body. No significant tolerance develops when nitrates are used intermittently. However; significant tolerance develops when nitrates are used continuously. This mechanism of nitrate tolerance is not well understood. The mechanism proposed is --> "Reduced ability to generate NO due to depletion of cellular SH radicals".', 'role': 'assistant'}]