This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: miscellaneous, Subject name: Anatomy
[{'content': "All are true about Wilson's disease except \nSelect and explain. \nA. Increase in liver Cu, B. Increase in urine Cu, C. Increase in Ceruolplasmin, D. Increase in serum Cu", 'role': 'user'}, {'content': 'Answer: C \nExplanation: Refer Robbins page no 849 Free copper dissociates and is taken up by hepatocytes. In the liver copper binds to an a2-globulin (apoceruloplasmin) to form ceruloplasmin, which is secreted into the blood. Excess copper is transpoed into the bile. Ceruloplasmin accounts for 90% to 95% of plasma copper. Circulating ceruloplasmin is eventually desialylated, endo- cytosed by the liver, and degraded within lysosomes, after which the released copper is excreted into bile. This degradation/excretion pathway is the primary route for copper elimination. The estimated total body copper is only 50 to 150 mg', 'role': 'assistant'}]