This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hemolytic anemia, Subject name: Pediatrics
[{'content': 'What is the mode of inheritance of Hereditary spherocytosis? \nSelect and explain. \nA. Autosomal dominant, B. Autosomal recessive, C. X-linked recessive, D. X-linked dominant', 'role': 'user'}, {'content': 'Answer: A \nExplanation: - Hereditary spherocytosis is inherited in an Autosomal dominant pattern. - Results from instability of spectrin & ankyrin which are major skeletal membrane proteins. - Degree of protein deficiency correlates with degree of hemolysis. - Demonstrated by Increase in osmotic fragility after 24hrs incubation of blood at 37oC.', 'role': 'assistant'}]