This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Medicine
[{'content': 'Which of the following is false regarding Multiple Sclerosis (MS)? \nSelect and explain. \nA. More common in women and age of onset is between 20-40 years of age, B. Risk factors include vitamin D deficiency and cigarette smoking, C. Pathological hallmark is axonal degeneration, D. HLA DRB1 in MHC class II is associated with 10% of disease risk', 'role': 'user'}, {'content': "Answer: C \nExplanation: Multiple sclerosis is an auto immune disease of central neural system with a relapsing and remitting or progressive course. The pathologic hallmark of disease is demyelination. Myelin specific antibodies are present on degenerating myelin sheaths. Surviving oligodendrocytes paially remyelinate surviving axons, which are called as shadow plaques. Reference: Harrison's Principles of Internal Medicine, 21st edition, p2661", 'role': 'assistant'}]