This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
[{'content': 'For the generation of a vaccine to prevent attachment of diarrhoeagenic E. coli to the specific receptors in the gastro-intestinal tract, vaccine should be directed against which of the following fimbrial adhesions factor? \nSelect and explain. \nA. CFA-1, B. CS-2, C. P Pilli, D. K88', 'role': 'user'}, {'content': "Answer: C \nExplanation: P-pilli are pyelonephritis associated pilli that are found an uropathic strains of E. coli and may play a role in pathogeneses of UTI. P pilli binds to Gal-Gal containing disaccharides of the globoseries of glycolipids. Globoseries of glycolipid are found primarily in the epithelial surface of urinary tract. E. coli which lack P pilli also lack the ability to produce UTI in experimental animals. They play no role in attachment of diarrheogenic E. coli to receptors in GIT and hence a vaccine against them would play no role in prevention of diarrhea from E. coli. Ref: Ananthnarayanan, 6th Edition, Page 253 ; Medical Microbiology By Greenwood, 14th Edition, Page 324 ; Irwin and Rippe's Intensive Care Medicine By Richard S. Irwin, 6th Edition, Page 1080 ; Foodborne Infections and Intoxications By Hans P. Riemann, 3rd Edition, Page 221.", 'role': 'assistant'}]