This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Enzymes, Subject name: Biochemistry
[{'content': 'Enzyme deficiency in Farber disease is \nSelect and explain. \nA. Arylsulfatase A, B. Sphingomyelinase, C. Ceramidase, D. Hexosaminidase A', 'role': 'user'}, {'content': 'Answer: D \nExplanation: DiseaseEnzyme deficiencyClinical symptomsTay-Sachs diseaseHexosaminidase AMental retardation, blindness, muscular weaknessFabry diseasea-GalactosidaseSkin rash, kidney failure (full symptoms only in males;X-linked recessive)MetachromaticleukodystrophyArylsulfatase AMental retardation and psychologic disturbances inadults; demyelinationKrabbe diseaseb-GalactosidaseMental retardation; myelin almost absentGaucher diseaseb-GlucosidaseEnlarged liver and spleen, erosion of long bones,mental retardation in infantsNiemann-PickdiseaseSphingomyelinaseEnlarged liver and spleen, mental retardation;fatal in early lifeFarber diseaseCeramidaseHoarseness, dermatitis, skeletal deformation,mental retardation; fatal in early lifeRef: Harper&;s Biochemistry; 30th edition; Chapter 24 Metabolism of Acylglycerols & Sphingolipids', 'role': 'assistant'}]