This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'True regarding unconjugated bilirubin is - \nSelect and explain. \nA. Not lipid soluble, B. More water soluble, C. Excreted by kidney easily, D. Bound with serum albumin', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Unconjugated bilirubin \n\nUnconjugated bilirubin is highly lipid soluble (lipophilic).\nIt is insoluble in water and tightly bound to albumin →\xa0cannot be excreted in urine.\nUnbound fraction, which is increased in hemolytic reactions (e.g. erythroblastosis fetalis), can cross blood-brain\xa0barrier because of lipophilic nature and can cause brain damage of newborn → Kernicterus.\n\nConjugated bilirubin\n\nConjugated bilirubin is water soluble and only loosely bound to albumin and thus is easily filtered by glomeruli and excreted in urine.', 'role': 'assistant'}]