This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Physiology
[{'content': 'All the following are signs of necrosis Except \nSelect and explain. \nA. Lipofuscin, B. Cell Membrane Rupture, C. Karyolysis, D. Karyorrhexis', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Lipofuscin, also known as "wear and tear pigment," appears in the form of brown granules in the cytoplasm of living cells but is not a sign of necrosis. Pyknosis, karyolysis, and karyorrhexis terms that describe nuclear changes in dead or irreversibly injured cells. Cell membrane rupture is also associated with cell death, and is a sign of irreversible cell injury.', 'role': 'assistant'}]