This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'Basic pathology in rickets – \nSelect and explain. \nA. Defective bone matrix formation, B. Defect in mineralization, C. Defect in osteoid formation, D. All of the above', 'role': 'user'}, {'content': 'Answer: B \nExplanation: To know the pathophysiology of rickets, one should know the structure of bone.\nBone consists of -\n\n\nProtein matrix i.e. osteoid --> also known as unmineralized bone.\nMineral phase, principally composed of calcium and phosphate, mostly in the form of hydroxyapatite.\n\n\nIn rickets osteoid (protein matrix) is formed normally but mineralization of this osteoid does not occur i.e. there is defective mineralization.\nRickets is a syndrome of diverse etiology characterized by defective mineralization of bone and epiphyseal cartilage (growth plate) of growing bones.', 'role': 'assistant'}]