This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'Which of following techniques tests is not used for detection of specific aneuploidy - \nSelect and explain. \nA. FISH, B. RT-PCR, C. QF-PCR, D. Microarray', 'role': 'user'}, {'content': 'Answer: D \nExplanation: FISH (Fluorescent in situ hybridisation) and PCR (polymerase chain reaction) like RT-PCR and QF PCR tests can detect specific aneuploidy.\nWhereas, microarray-based CGH (comparative genomic hybridization) test can be used as high-resolution whole-genome scan for the detection or screening of unknown (non-specific) abnormalities, mutation or genomic imbalance including deletions, duplication and aneuploidies. Microarray-based CGH cannot detect balanced translocations or inversions.\nSo FISH and PCR can detect specific (known) chromosomal abnormalities whereas microarray-based CGH is better suited for screening unknown (non-specific) chromosomal abnormalities.', 'role': 'assistant'}]