This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Destruction of fat in acute pancreatitis is due to - \nSelect and explain. \nA. Lipase and elastase, B. Lipase and trypsin, C. Secretin, D. Cholecystokinin and trypsin', 'role': 'user'}, {'content': 'Answer: B \nExplanation: An enzyme activated by trypsin is phospholipase A2. This enzyme splits a fatty acid off lecithin, forming lysolecithin. Lysolecithin damages cell membrane. It has been hypothesized that in acute pancreatitis phospholipase A2 is activated in the pancreatic ducts, with the formation of lysolecithin from lecithin that is a normal constituent of bile. This cause disruption of pancreatic tissue and necrosis of surrounding fat.', 'role': 'assistant'}]