This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Apoptosis, Subject name: Pathology
[{'content': 'CD 95 is a marker of: \nSelect and explain. \nA. Intrinsic pathway of apoptosis., B. Extrinsic pathway of apoptosis., C. Necrosis of cell., D. Cellular adaption.', 'role': 'user'}, {'content': 'Answer: B \nExplanation: -In the activation of Extrinsic pathway of apoptosis, binding of Fas ligand takes place to CD95 (Fas; member of TNF receptor family) or binding of TRAIL (TNF related apoptosis-inducing ligand) attaches to death receptors DR4 and DR5. -This induces the association of FADD (Fas-associated death domain) and procaspase-8 to death domain motifs of the receptors resulting in activation of caspase 8 (in humans caspase 10) which finally activates caspases- 3 and 7 that are final effector caspases. ALSO KNOW: Necroptosis- cell death is initiated by engagement of TNF receptors. Receptor-interacting protein (RIP) kinases are activated, initiating a series of events that result in the dissolution of the cell, much like necrosis Pyroptosis - proinflammatory programmed cell death that is different than apoptosis. Pyroptosis involves caspase-1 and 11.', 'role': 'assistant'}]