This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Acantholytic cells in Pemphigus are derived from - \nSelect and explain. \nA. Stratum granulosum, B. Stratum basale, C. Langerhans cell, D. Stratum spinosum', 'role': 'user'}, {'content': 'Answer: D \nExplanation: First know about the layers of skin\xa0—\n\n\nEpidermis\xa0(from superficial to deep) -\n\tStratum corneum (Horny layer)\n\tStratum granulosum (granular cells layer)\nStratum spinosum\xa0(Prickle cell layer)\n\tStratum basale (Basal cell layer)\nDermis —\n\tPapillary dermis\n\tReticular dermis\n\n\nPemphigus\xa0is characterized by acantholysis. Acantholysis is separation of epidermal cells from one another. This\xa0separation occurs due to antibodies (IgG) against the intercellular substances.\nAcantholysis occurs in different layers of epidermis in different types of pemphigus.\nPemphigus vulgaris and ---->\xa0Acantholysis occur in between\xa0basal cells and cells of prickle cell layer (Stratum pemphigus vegetans spinosum).\xa0Some books also state that acantholysis occurs in\xa0suprabasal layer. Suprabasal layer\xa0is most probably,\xa0stratum spinosum\xa0as it is seen above basal layer\nPemphigus foliaceous and--\xa0Acantholysis occurs in\xa0stratum granulosum.\n\nPemphigus erythematosus\nSo,\xa0Stratum spinosum\xa0is involved in pemphigus vulgaris and pemphigus vegetans and\xa0stratum granulosum\xa0is involved in pemphigus foliaceous and pemphigus etythematosus.\nBut, the answer should be stratum spinosum, as pemphigus vulgaris is the most common type of pemphigus and most probably they have asked about it.', 'role': 'assistant'}]