This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
[{'content': 'Hypoglycemia in new born is seen in:a) IUGRb) Mother with hypothyroidismc) Rh incompatibilityd) Macrosomiae) Hyperthyroidism \nSelect and explain. \nA. b, B. ad, C. ac, D. ab', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Hypoglycemia is defined as blood glucose of less than 40 mg/dL, irrespective of the gestational age.\nCauses of hypoglycemia Let us see each option one by one.\nOption ‘a’ IUGR\n“Hypoglycemia is due to shortage of glycogen reserve in the liver as a result of chronic hypoxia”\nDutta Obs. 6/e, p 465\nOption ‘b’ Mother with hypothyroidism\nMaternal hypothyroidism can cause hypoglycemia if it leads to fetal hypothyroidism also but “Maternal TSH receptor bloking antibodies can cross the placenta and cause fetal thyroid dysfunction.They however have little or no effect on fetal thyroid function even though they too cross the placenta.”.\nWilliams 23/e, p 1131, 1132\nSo according to latest editon of Williams, maternal hypothyroidism does not lead to fetal hypothyroidism, thus it does not cause fetal hypoglycemia.\nOption ‘c’ Rh incompatibility\nThere is no definite correlation between Rhincompatibility and hypoglycemia.\nOption ‘d’ Macrosomia\nMacrosomia usually is due to maternal diabetes which inturn results in fetal hyperinsulinemia due to beta cell hyperplasia, which further results in neonatal hypoglycemia.\nDutta Obs. 6/e, p 287\nOption ‘e’ Hyperthyroidism : Hyperthyroidism is a diabetes like state with increased insulin resistance.', 'role': 'assistant'}]