This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Histopathological examination reveals the diagnosis as: \nSelect and explain. \nA. Ewing sarcoma, B. Kaposi Sarcoma, C. Hodgkin lymphoma, D. Burkitt lymphoma', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Characteristic\xa0 malignant\xa0 cells\xa0 of\xa0 Hodgkin’s\xa0 diseases\xa0 are\xa0large\xa0 cells\xa0 known\xa0 as\xa0 Reed–Sternberg\xa0 (RS)\xa0 cells\xa0 (typical\xa0and\xa0 variant),\xa0 20–50\xa0 micrometers\xa0 in\xa0 diameter,\xa0 abundant,\xa0amphophilic, finely granular/homogeneous cytoplasm; two\xa0mirror-image nuclei (owl eyes) each with an eosinophilic\xa0nucleolus\xa0 and\xa0 a\xa0 thick\xa0 nuclear\xa0 membrane\xa0 (chromatin\xa0 is\xa0\xa0distributed at the cell periphery). One or two percent\xa0 of\xa0\xa0these\xa0 malignant\xa0 cells\xa0 are\xa0 admixed\xa0 within\xa0 a\xa0 reactive\xa0 cell\xa0infiltrate composed of variable proportions of lymphocytes,\xa0 histiocytes,\xa0 eosinophils,\xa0 and\xa0 plasma\xa0 cells.\xa0\xa0The\xa0 Reed–Sternberg cells are identified as large often binucleated cells\xa0with prominent nucleoli\xa0and an unusual CD15+, CD30+\xa0 immunophenotype.\xa0 In\xa0 approximately\xa0 50%\xa0 of\xa0 cases,\xa0 the\xa0Reed–Sternberg cells are infected by the\xa0Epstein-Barr virus.\nRef: Shafer’s Ed 7th Pg 187', 'role': 'assistant'}]