This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Gluconeogenesis, Subject name: Biochemistry
[{'content': "A five-year-old boy with coarse facial features, mental retardation, dysostosis multiplex. Corneal clouding was not present. What is the diagnosis: \nSelect and explain. \nA. MPS Type IV, B. Hurler disease, C. Hunter disease, D. Gaucher's disease", 'role': 'user'}, {'content': 'Answer: C \nExplanation: Coarse facial features is a typical feature of Mucopolysaccharidosis (MPS). Hunter disease : MPS Type II, Iduronate Sulfatase is deficient. X-linked recessive, so occurs exclusively in males. No corneal clouding. Dermatan sulphate & Heparin Sulphate accumulates. Accumulation of Heparin Sulphate leads to mental retardation. Corneal clouding is present in Hurler disease so option 2 is ruled out', 'role': 'assistant'}]