This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hematology, Subject name: Pharmacology
[{'content': 'All of the following are used in management of acute severe bleeding due to warfarin overdose except:- \nSelect and explain. \nA. Withhold the anticoagulant, B. Vitamin K1, C. Protamine sulphate, D. Fresh frozen plasma', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Management of warfarin overdose is done as follows: *INR < 5 but above therapeutic range - Discontinue warfarin temporarily and resta at low dose. *INR 5-9 - Vitamin K1 (1 mg oral) *INR > 9 but no bleeding - Vitamin K1 (2 - 3 mg oral) *INR > 20 or bleeding - Four factor prothrombin complex or Fresh frozen plasma.', 'role': 'assistant'}]