This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney and ureter, Subject name: Surgery
[{'content': "The most impoant determinant of prognosis in Wilm's tumor: \nSelect and explain. \nA. Stage of disease, B. Loss of heterozygosity of chromosome 1p, C. Histology, D. Age less than one year at presentation", 'role': 'user'}, {'content': 'Answer: C \nExplanation: Most impoant prognostic factor in most of malignancies- Stage (TNM) Exception- Wilms tumor and soft tissue sarcoma In Wilms tumor, Most impoant Prognostic Factor- Histology > Stage In soft tissue sarcoma, most impoant prognostic factor - Tumor grade', 'role': 'assistant'}]