This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Auto Immune Disorders Introduction, Subject name: Pathology
[{'content': 'In thymus, which gene is responsible for recognition of self-antigens? \nSelect and explain. \nA. NOTCH 1, B. AIRE, C. Rb, D. PTEN', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Immunologic tolerance is the phenomenon of unresponsiveness to an antigen induced by exposure of lymphocytes to that antigen. A protein called AIRE (autoimmune regulator) stimulates expression of some "peripheral tissue-restricted" self-antigens in the thymus It is critical for deletion or negative selection of immature T cells specific for these antigens. Mutations in the AIRE gene are the cause of an autoimmune polyendocrinopathy. In the CD4+ T-cell lineage, some of the cells that see self-antigens in the thymus do not die but develop into regulatory T cells.', 'role': 'assistant'}]