This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Extravascular Changes, Subject name: Pathology
[{'content': 'Arrange the steps in cellular changes in inflammation in the sequence: 1. Chemotaxis 2. Diapedesis3. Margination4. Respiratory burst 5. Phagocytosis \nSelect and explain. \nA. 2-1-3-5-4, B. 1-3-2-5-4, C. 5-3-1-2-4, D. 3-2-1-5-4', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Steps in cellular changes in inflammation: In the lumen: margination, rolling, and adhesion to endothelium Migration across the endothelium and vessel wall - Transmigration or diapedesis Chemotaxis - After exiting the circulation, leukocytes move in the tissues toward the site of injury by a process called chemotaxis Recognition of the offending agents by TLRs and other receptors Leucocyte activation Phagocytosis - involves sequential steps: Recognition and attachment of the paicle to be ingested by the leukocyte; Engulfment, with subsequent formation of a phagocytic vacuole; and Killing of the microbe and degradation of the ingested material (O2 Respiratory burst)', 'role': 'assistant'}]