This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hypeension, Arrhythmias, Dyslipidemia, Subject name: Pharmacology
[{'content': 'False about Aliskiren is: \nSelect and explain. \nA. It is an oral renin inhibitor, B. It can result in hyperkalemia, C. It is p-glycoprotein inhibitor, D. Blocks conversion of angiotensinogen to Angiotensin I', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Aliskiren: MOA: Potent competitive inhibitor of renin. Binds the active site of renin and blocks conversion of angiotensinogen to Angiotensin I. Pk: Bioavailability of aliskiren is low but still used orally as it has high affinity and potency. It is a substrate for P- glycoprotein (Not the inhibitor). It can cause hyperkalemia by inhibiting the RAAS through which K+ is removed from the body. It is well tolerated in: Elderly population. Hepatic disease and renal insufficiency patients. Type 2 diabetes patients.', 'role': 'assistant'}]