This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Disorders in Menstruation, Subject name: Gynaecology & Obstetrics
[{'content': 'Withdrawal bleeding following administration of progestogen in a case of secondary amenorrhea indicates all except \nSelect and explain. \nA. Absence of pregnancy, B. Production of endogenous estrogen, C. Endometrium is responsive to estrogen, D. Defect in pituitary gonadal axis', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ans. is d, i.e. Defect in pituitary gonadal axisRef: Dutta Gynae 6th/ed, p467; Leon Speroff 7th/ed, p404-409Withdrawal bleeding following administration of progesterone suggests:* The uterus is sufficiently primed with estrogen, i.e. production of endogenous estrogen is normal which means. Ovaries and hypothalamic pituitary axis are functioning normally.* The outflow tract (uterus) is normal and endometrium is responsive to estrogen.* There is a defect in production of progesterone (so pregnancy ruled out).', 'role': 'assistant'}]