This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'VEGF is involved in all of the process of angiogenesis except: \nSelect and explain. \nA. Migration and proliferation of endothelial cells, B. Capillary sprouting, C. Enhances the production of ECM proteins, D. Increased vascular permeability', 'role': 'user'}, {'content': 'Answer: C \nExplanation: VEGFs,\xa0mainly\xa0VEGF-A, stimulates both migration and proliferation of endothelial cells, thus initiating the process of capillary sprouting\xa0in\xa0angiogenesis.\xa0It\xa0promotes\xa0vasodilation\xa0by stimulating the production of NO and contributes to the formation of the vascular lumen.\nNewly formed vessels are leaky because of incomplete interendothelial junctions and because VEGF, the growth factor that drives angiogenesis, increases vascular permeability.\nTGF-β suppresses endothelial proliferation and migration, and enhances the production of ECM proteins.\nRobin’s Textbook of pathology 10th ed\xa0 Page 91', 'role': 'assistant'}]