This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'HER-2/ neu receptor play a role in: \nSelect and explain. \nA. Predicting therapeutic response, B. Determining treatment for recurrence of tumor, C. Diagnosis of breast Ca, D. Screening of breast Ca', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Predicting therapeutic response o Overexpression of HER-2/neu in breast cancer patients is associated with poor prognosis and increases disease recurrence. o Overexpression HER-2/neu also predicts good response to transtuzumab (Herceptin), a drug approved for HER-2/ neu overexpressing breast cancer. o Because of its prognostic role as well its ability to predict response to transtuzumab (Herceptin), breast cancers are routinely checked for overexpression of HER-2/neu.", 'role': 'assistant'}]