This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: FMGE 2018, Subject name: Pharmacology
[{'content': 'Which of the following drugs is a direct inhibitor of clotting factor Xa? \nSelect and explain. \nA. Apixaban, B. Argatroban, C. Fondaparinux, D. Aspirin', 'role': 'user'}, {'content': 'Answer: A \nExplanation: All the drugs ending with XA BAN are direct Xa inhibitor XaBlocker Impoant ones are :- (1) Rivaroxaban (2) Apixaban (3) Edoxaban (4) Betrixaban (b) Argatroban - Direct thrombin inhibitors. (synthetic non-peptide compound which binds reversibly to the catalytic site of thrombin but not to the substrate recognition site)Argatroban uses ---- Tx of Thrombosis and for PCI(PCI = Per cutaneous Intervention) in HIT patients (HIT= Heparin induced thrombocytopenia ) (c) Fondaparinux - Indirect thrombin inhitor. (Penta-saccharidewith specitic sequence that binds to AT -III with high affinity inducing an irreversible conformational change to selectively in actively factor Xawithout binding thrombin) Fondaparinux use - prophylaxis and Tx of DVT &PE(Pulmonary Embolism) as well as ACS (Acute coronary syndrome) (d)Aspirin - Thromboxane synthesis inhibitor Aspirin use - CAD (Coronary Aery Disease), Stroke.', 'role': 'assistant'}]