This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'The tensile strength of wound after laparoscopic cholecystectomy in a 30 years old woman depends upon: \nSelect and explain. \nA. Replacement of type 3 collagen, B. Macrophage aetivity/snvasion, C. Extensive crosslinking of tropocollagen, D. Granulation tissue', 'role': 'user'}, {'content': "Answer: C \nExplanation: The recovery of tensile strength results from the excess of collagen synthesis over collagen degradation\xa0during the first 2 months of healing, and, at later times, from structural modifications of collagen fibers\xa0(cross-linking, increased fiber size) after collagen synthesis ceases.\n'Recovery of Tensile Strength: Fibrillar collagens (mostly type I collagen) form a major portion of the\xa0connective tissue in repair sites and are essential for the development of strength in healing wounds. Net\xa0collagen accumulation, however, depends not only on increased collagen synthesis but also on decreased\xa0degradation. When sutures are removed from an incisional surgical wound, usually at the end of the first\xa0week, wound strength is approximately 10% that of unwounded skin.\nWound strength increases rapidly\xa0over the next 4 weeks, slows down at approximately the third month after the original incision, and\xa0reaches a plateau at about 70% to 80% of the tensile strength of unwounded skin. Lower tensile strength\xa0in the healed wound area may persist for life. The recovery of tensile strength results from the excess of\xa0collagen synthesis over collagen degradation during the first 2 months of healing, and, at later times,\xa0from structural modifications of collagen fibers (cross-linking, increased fiber size) after collagen\xa0synthesis ceases.'- Robbins 8/e p105-106", 'role': 'assistant'}]