This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Ulcer, Subject name: Pharmacology
[{'content': 'Which of the following drugs have least affinity for CYP3A4? \nSelect and explain. \nA. Omeprazole, B. Lansoprazole, C. Esomeprazole, D. Rabeprazole', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ans. (D) Rabeprazole(Ref: Katzung 13th/1060, KDT 8th/e p701)Proton pump inhibitors are metabolized by CYP3A4 and CYP2C19. They are also inhibitors of these enzymes. Rabeprazole and pantoprazole has less affinity for these enzymes.', 'role': 'assistant'}]