This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': 'Renal toxicity though negligible is associated with which of the following? \nSelect and explain. \nA. Entecavir, B. Telbivudine, C. Tenofovir, D. Lamivudine', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Tenofovir is an acyclic nucleotide analogue and potent antiretroviral agent used to treat both wild-type and lamivudine-resistant HBV. Side effects: Negligible renal toxicity and mild reduction in bone density. Note: Telbivudine, a cytosine analogue Side effects: Asymptomatic creatine kinase elevation and peripheral neuropathy. Entecavir, a cyclopentyl guanosine analogue polymerase inhibitor (the most potent of the HBV antivirals) Lamivudine, inhibits reverse transcriptase activity of both HIV and HBV and is a potent and effective agent for patients with chronic hepatitis B. Ref: Harrison, Edition-18, Page-2573', 'role': 'assistant'}]