This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Physiology
[{'content': 'Production of bile takes place in: \nSelect and explain. \nA. The gall bladder, B. Kupffer cells, C. Hepatic duct, D. Hepatocytes', 'role': 'user'}, {'content': 'Answer: D \nExplanation: PHYSIOLOGIC ANATOMY\xa0 OF BILIARY SECRETION\nBile is secreted in two stages by the liver:\n1.\xa0 The initial portion is secreted by the principal functional cells of the liver, the hepatocytes; this initial\xa0secretion contains large amounts of bile acids, cholesterol, and other organic constituents. It is secreted\xa0into minute bile canaliculi that originate between the hepatic cells.\n2.\xa0 Next,\xa0the\xa0bile\xa0flows\xa0in\xa0the\xa0canaliculi\xa0toward\xa0the interlobular septa, where the canaliculi empty into\xa0terminal\xa0bile\xa0ducts\xa0and\xa0then\xa0into\xa0progressively larger ducts, finally reaching the hepatic duct and common bile duct. From these ducts, the bile either empties directly into the duodenum or is diverted for minutes up to several hours through the cystic duct into the gallbladder. In its course through the bile ducts, a second portion of\xa0 liver\xa0secretion\xa0is\xa0added\xa0to\xa0the\xa0initial\xa0 bile. This\xa0additional secretion is a watery solution of sodium and bicarbonate\xa0ions\xa0secreted\xa0by\xa0epithelial\xa0cells that\xa0line\xa0the ductules\xa0and\xa0ducts.\xa0\xa0\nAbout 500 ml of bile is secreted per day.', 'role': 'assistant'}]