This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'Beaded ribs with epiphysial swelling is a feature of: \nSelect and explain. \nA. Vit D deficiency, B. Vit A deficiency, C. Vit C deficiency, D. Vit K deficency', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Rickets is characterized by the continued formation of the collagen matrix of bone, but incomplete mineralization results in soft, pliable bones.\xa0\nIn osteomalacia, demineralization of pre-existing bones increases their susceptibility to fracture. Insufficient exposure to daylight and/or deficiencies in vitamin D consumption occur predominantly in\xa0infants and the elderly.\xa0\nVitamin D deficiency is more common in the northern latitudes, because less vitamin D synthesis occurs in the skin as a result of reduced exposure to ultraviolet light.\xa0\nLoss-of-function mutations in the vitamin D receptor result in hereditary vitamin D-deficient rickets.\nVitamin D deficient rickets leads to epiphyseal swelling with beaded ribs known as Rachitic rosary.\n\nKey Concept:\nVitamin D deficient rickets leads to epiphyseal swelling with beaded ribs known as Rachitic rosary.\nRef: Lippincott’s illustrated reviews for biochemistry, 7th edition.', 'role': 'assistant'}]