This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Anatomy
[{'content': 'All of the following factors tend to increase the volume of distrubtion of a drug except \nSelect and explain. \nA. High plasma protein binding, B. Low ionization at physiological pH values, C. High lipid solubility, D. High tissue binding', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ref-katzung 10/e per,35 If a drug is highly bound to plasma proteins ,it is more likely to stay in blood.thus it's Vd will be less . Low ionization ours the distribution of a drug because unionized molecules can cross the membrane of blood vessels and the tissue More lipid soluble drugs can easily cross the membrane and are more likely to be highly distributed", 'role': 'assistant'}]