This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Which statement about first order kinetics is TRUE? \nSelect and explain. \nA. Constant amount of drug is eliminated, B. Rate of elimination remains constant, C. Rate of elimination is directly propoional to drug concentration, D. Free drug concentration increases after successive doses', 'role': 'user'}, {'content': 'Answer: C \nExplanation: In first order/exponential kinetics: Rate of elimination is propoional to the plasma drug concentration Clearence and tl/2 remains constant Constant fraction of the drug is eliminated in unit time Most of the drugs follow first order kinetics Zero order/linear kinetics Rate of elimination remains constant irrespective of the plasma drug concentration. CL decreases with increase in plasma drug concentration Constant amount of the drug is eliminated in unit time', 'role': 'assistant'}]