This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolic Bone Disease, Subject name: Orthopaedics
[{'content': 'Osteogenesis imperfecta is due to \nSelect and explain. \nA. Defective synthesis of type I collagen, B. Growth hormone dysfunction, C. Inborn error of the methionine metabolism, D. Boney abnormality confined to the metaphysis', 'role': 'user'}, {'content': 'Answer: A \nExplanation: (Defective synthesis of type I collagen) (153-55-A)Osteogenesis Imperfecta (brittle bones) 1:20,000It is basically a connective tissue disorder (defective synthesis of type I collagen) heterogenous disorders1. Osteopenia2. Propensity to fracture3. Laxity of ligaments4. Blue sclerae5. Crumbling teeth or dentinogenesisType I collagen (Bone, ligament, tendon and skin)Type II collagen (Cartilage)Type III collagen (Blood vessels, muscle and skin)Humocvstinuria - is in bom error of methionine metabolism', 'role': 'assistant'}]