This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
[{'content': 'Antimalarial(s) to be avoided in pregnancy:a) Chloroquineb) Quininec) Primaquined) Anti-folatese) Tetracyclines \nSelect and explain. \nA. a, B. b, C. ce, D. ae', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Malaria is life threatening in pregnancy, therefore benefits of treatment outweigh the potential risk of antimalarials.\nThe commonly used antimalarials are not contraindicated in pregnancy.\nChloroquine is the drug of choice for treatment and prophylaxis (even in pregnancy) of all varieties of malaria.\n\nHarrison 17/e, p 1293, Williams Obs. 24/e, p 1257\n\nAccording to Williams 24/e cloroquine should be used throughout pregnancy and primaquine should be used during postpartum period for malaria in pregnant moment.\nIn cloroquine resistant P. vivax malaria-mefloquine is the DOC.\nIn cloroquine resistant P. falciparum malaria-mefloquine or quinine is the drug of choice.\n\nChemoprophylaxis:\n\nPregnant women in endemic areas are candidates for chemoprophylaxis.\nIt is also recommended for travel to endemic areas.\nChloroquine is the drug of choice for prophylaxis in pregnancy.\nMefloquine is the only drug adviced for pregnant women who travel to areas with drug resistant malaria. This drug is generally considered safe in 2nd and 3rd trimester of pregnancy and the limited data on 1st trimester exposure are reassuring.\n\nHarrison 17/e, p 1293\n\n“Proguanil is considered safe for antimalarial prophylaxis in pregnancy.”\n\nHarrison 17/e, p 1293\nAntimalarials contraindicated in pregnancy:\n\n“Tetracycline and doxycycline cannot be given to pregnant women”.\n\nHarrison 17/e, p 1291, 1289\n\n“Primaquine should not be given to pregnant women and neonates.\n\nHarrison 17/e, p 1293\n\n“Primaquine and doxycycline are contraindicated in pregnancy”.\n\nWilliams 24/e, p 1257', 'role': 'assistant'}]