This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Pathology
[{'content': 'Most common cause of hereditary spherocytosis? \nSelect and explain. \nA. Actin, B. Glycophorin, C. Spectrin-Ankyrin complex, D. Band 4', 'role': 'user'}, {'content': 'Answer: C \nExplanation: About 60% of HS cases results from a defect in the ankyrin-spectrin complex , with genes for a or b subunits of spectrin dimer (SPTA1 ,SPTB) or for ankyrin (ANK1)being implicated in diff genetic type. 25% ~> involve deficiency in band 3, the anion channel. Ref:Postgraduate Hematology by Victor Hoffbrand ,pg:131 Ref Robbins 9/e pg 412', 'role': 'assistant'}]