This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'What is the karyotype that you expect in chromosomal studies in a young male with hypogonadism and infeility and suspected Klinefelter syndrome? \nSelect and explain. \nA. 47XXY, B. 45X0, C. 46XXY, D. 45XXX', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Klinefelter syndrome is the most common chromosomal disorder associated with male hypogonadism and infeility. It is defined classically by a 47XXY karyotype with variants that demonstrate additional X and Y chromosomes. The syndrome is characterized by hypogonadism (small testes, azoospermia, oligospermia), gynecomastia in late pubey, psychosocial problems, hyalinization and fibrosis of the seminiferous tubules, and elevated urinary gonadotropin levels.', 'role': 'assistant'}]