This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'Substrate affinity to enzyme in Competitive inhibition \nSelect and explain. \nA. Decreases, B. Increases, C. Any of the above, D. Does not change', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Significance of Km (Michaelis Constant):\n\nKm is substrate concentration at 1/2 Vmax\nConstant for an enzyme substrate pair\nIt is called signature of the enzyme\nHigher the Km, lower is the affinity of the enzyme towards the substrate\nLower the Km, higher is the affinity of the enzyme towards the substrate.\n\nFeatures of competitive inhibition:\n\nKm increases, hence the affinity is lowered\nVmax remains the same.\n\nFeatures of noncompetitive inhibition:\n\nKm remains the same\nVmax decreases.', 'role': 'assistant'}]