This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
[{'content': 'Which is seen in chediak Higashi syndrome \nSelect and explain. \nA. Neutopenia, B. Defective microbial killing, C. Presence of large granules in neutrophils, D. All of the above', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ref Harrison 16/e p,353:,354, Robbins 9/e p238 Chediak Higashi syndrome: Autosomal recessive inheence Due to defect in lysosomal transpo protein LYST. Clinical feature include: primary immune deficiency, neutropenia , defective microbial killing,impaired chemotaxis,hypopigmentation, photophobia, nystagmus. Microscopic examination shows giant peroxidase positive inclusion in the cytoplasm of leukocytes', 'role': 'assistant'}]