This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cellular Pathology, Subject name: Pathology
[{'content': 'Which of the following helps in cell to cell adhesion? \nSelect and explain. \nA. Interleukins, B. Interferons, C. E-Cadherin, D. Matrix metallo proteinase', 'role': 'user'}, {'content': "Answer: C \nExplanation: Ref: Robbin's Pathology, 9th ed. pg. 307* Normal epithelial cells are tightly glued to each other and the ECM by a variety of adhesion molecules.* E-cadherin, a cell surface protein, maintains intercellular adhesiveness serving to hold the cells together and relay signals between the cells.* In several epithelial tumors, including adenocarcinomas of the colon, stomach, and breast, E-cadherin function is lost.* TNF and IL-1 (interleukins) serve critical roles in leukocyte recruitment by promoting adhesion of leukocytes to endothelium and their migration through vessels.* Interferons are inflammatory cytokines.* Matrix metalloproteinase (MMP) regulate tumor invasion by:# Remodelling insoluble components of the basement membrane and interstitial matrix# By releasing ECM-sequestered growth factors.", 'role': 'assistant'}]