This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Barbiturate ingestion is associated with hyperophy of which cellular organelle? \nSelect and explain. \nA. Mitochondria, B. Endoplasmic reticulum, C. Golgi apparatus, D. Nucleolus', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Hyperophy usually refers to increase in size of cells or tissues, but sometimes a subcellular organelle may undergo selective hyperophy. Individuals treated with drugs such as barbiturates show hyperophy of the smooth endoplamic reticulum (ER) in hepatocytes, which is an adaptive response that increases the amount of enzymes (cytochrome P-450 mixed function oxidases) available to detoxify the drugs. Ref: Robbins, 8th edition, Chapter 1.', 'role': 'assistant'}]