This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anatomy of skin, Subject name: Dental
[{'content': 'Weakest poion of Dermo- epidermal junction is \nSelect and explain. \nA. Stratum Basale, B. Lamina Lucida, C. Lamina Densa, D. Lamina Fibroreticularis', 'role': 'user'}, {'content': 'Answer: B \nExplanation: LAMINA LUCIDA * Electron-lucent zone under hemidesmosome on EM; weakest link of BMZ (Basement membrane zone). * Comprised of anchoring filaments (laminin-332), laminin-1, fibronectin, nidogen (entactin), uncein and poion of BPAG2. Anchoring Filaments :- * Delicate filaments emanating perpendicularly from HD(hemi-desmosomes) which stretch from plasma membrane to lamina densa; product of basal keratinocytes; smaller than anchoring fibrils * Laminin-332: also known epiligrin (truncated laminin), laminin-5, kalinin, and nicein; glycoprotein serving as major component of anchoring filaments; major attachment factor for keratinocytes and binds a6b4 integrin at hemidesmosome . Ref:- Sima Jain; pg num:- 7', 'role': 'assistant'}]