This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
[{'content': 'Division and differentiation of B cells leading to production of plasma cells both require: \nSelect and explain. \nA. CD4 and CD8, B. Interleukin (IL)-1 and IL-5, C. IL-5 only, D. IL-4 and IL-6', 'role': 'user'}, {'content': "Answer: D \nExplanation: Amplification of pre B cells along the pathway leading to the terminal plasma cell requires interleukin (IL)-4 and IL-6. IL-1 is involved mainly in T-cell activation. CD4 and CD8 function during interaction of the T cell with antigen-presenting cells. Ref: Harrison's Principles of Internal Medicine, 17th Edition, Chapter 308, Page 2025, Table 308-6", 'role': 'assistant'}]