This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
[{'content': 'Recurrent abortion in 1st trimester, investigation of choice: \nSelect and explain. \nA. Karyotyping, B. SLE Ab, C. HIV, D. TORCH infection', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Hence karyotyping of the both partners is recommended in recurrent miscarriage. Prenatal diagnosis is usually advised in\xa0the next pregnancy.\nAs discussed earlier, infections be it HIV / TORCH are not a cause of recurrent abortion.\nBecause TORCH infections are not a cause of recurrent abortions:\nTORCH profile should not be included in the set of investigations done to find out the cause of recurrent abortion\nInvestigative measures useful in the evaluation of recurrent early pregnancy loss:\nNovak 14/e, p 1302; Leon Speroff, 1090\n\nParental peripheral blood karyotypingQ with banding technique.\nAssessment of the intrauterine cavity with either office hysteroscopy or hysterosalpingography.\nThyroid function tests, serum prolactin levels if indicated.\nAnticardiolipin antibody and lupus anticoagulant testing (aPTT or Russell Viper venom testing).\nComplete blood counts with platelet count.\nThrombophilia testing:\n\n– Factor V leiden, prothrombin gene mutation, Protein S activity.\n– Serum homocysteine level.\n– In the presence of a family or personal history of venous thromboembolism, protein C and antithrombin activity.\nThe American college of obstetricians and Gynaecology recognizes only 2 types of tests as having clear value in the investigation of recurrent miscarriages:\n\nParental cytogenetic analysis\nLupus anticoagulant and anticardiolipin antibodies assay.\n\nWilliams Obs 23/e, p 241', 'role': 'assistant'}]