This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Disorders of Adrenal Gland, Subject name: Medicine
[{'content': 'Congenital 17-hydroxylase deficiency leads to hypeension due to accumulation of? \nSelect and explain. \nA. Deoxycoicosterone, B. Coisol, C. 17 hydroxy pregnediol, D. 17 hydroxy progesterone', 'role': 'user'}, {'content': 'Answer: A \nExplanation: * Two forms of adrenal hyperplasia (ie, 11-hydroxylase and 17-hydroxylase deficiency) result in hypeension due to the accumulation of supraphysiologic concentrations of deoxycoicosterone. * This weak mineralocoicoid has little consequence at physiologic concentrations but causes sodium retention and hypeension at the supraphysiologic concentrations that occur in these conditions.', 'role': 'assistant'}]