This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Anatomy
[{'content': 'Maintenance dose rate of drug depends primarily on \nSelect and explain. \nA. Volume of distrubtion, B. Half life, C. Lipid solubility, D. Total body clearance', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ref-KDT 6/e p34 Maintenance dose is determined by clearance Maintenance dose=CLxPlasma concentration required', 'role': 'assistant'}]