This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Primary Immunodeficiency, Subject name: Pediatrics
[{'content': 'Most sensitive antibody for SLE: \nSelect and explain. \nA. Anti-nuclear, B. Anti-ds DNA, C. Anti-Smith, D. Anti-histone', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Autoantibodies in Systemic Lupus Erythematosus (SLE) Antibody Clinical Utility Antinuclear antibodies Best screening test/Most sensitive Anti-ds DNA Specific, correlate with disease activity, nephritis, vasculitis Anti-Sm Most Specific for SLE, marker for CNS lupus Anti-RNP Not specific for SLE Anti-Ro/La (SS-A) Sicca syndrome, neonatal lupus with congenital hea block Anti-histone Drug-induced lupus', 'role': 'assistant'}]