This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'The most appropriate management for maintaining patency of ductus aeriosus in a neonate is - \nSelect and explain. \nA. Prostaglandin E1, B. Oxygen, C. Nitric oxide, D. Indomethacin', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Prostaglandin E1 o Ductus aeriosus remains patent in the uterus in the fetal life because of high level of vasodilators especially prostaglandin E, in the blood. o After bih the prostaglandin synthesis is inhibited by inhibition of cycloxygenase at bih. o So if the patency of ductus aeriosus has to be maintained --> prostaglandins should be given. o The drug which is specifically used for this is prostaglandin E, (Misoprost, Rioprostil) o If the ductus aeriousus has to be closed, prostaglandin synthesis inhibitor - Indomethacin should be given.", 'role': 'assistant'}]