This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Mood Disorders, Subject name: Psychiatry
[{'content': 'Which of the following medication is least effective against depression? \nSelect and explain. \nA. Valproate, B. Lamotrigine, C. Lithium, D. Aripiprazole', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Valproate Antiseizure drug In addition, it is used as a mood stabilizer in bipolar disorder and as prophylactic treatment for migraine. Least effective against depression Treatment : Pharmcotherapy- TCAs SSRI(M.C.) SNRI MAO inhibitors Atypical antidepressants Psychotherapy ECT', 'role': 'assistant'}]