This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous (Urinary Tract), Subject name: Pathology
[{'content': 'Alport syndrome is characterized by antibodies act against? \nSelect and explain. \nA. Laminin, B. Fibronectin, C. Collagen IV, D. Heparan sulphate', 'role': 'user'}, {'content': "Answer: C \nExplanation: Ans is 'c' i.e. Collagen IV o Alport syndrome is a type hereditary nephritis characterized by glomerulonephritis, sensorineural hearing loss and eye defects. It is due to defect in a -5 chain of collagen IV (COL4 A5).o The most common inheritence is X-linked which causes defect in a -5 chain of collagen IV. Very rare autosomal forms (dominant and recessive) also exist, which affect a-3 or a-4 chains of collagen 4 (COL 4 A3 or COL 4 A4).", 'role': 'assistant'}]