This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': "An infant presents to OPD with a history of vomiting and poor feeding. Musty odor is present in baby's urine. Guthrie test was done and found to be positive. Which of the following is not a treatment modality for this patient? \nSelect and explain. \nA. Administration of large neutral amino acids, B. Sapropterin\xa0dihydrochloride intake, C. Low–phenylalanine diet, D. None\xa0of the above", 'role': 'user'}, {'content': 'Answer: D \nExplanation: Treatment of Classical PKU\xa0\n\nA low-phenylalanine diet.\xa0\nAdministration of large neutral amino acids (LNAAs) is another approach to diet therapy.\xa0\nSapropterin dihydrochloride (Kuvan), a synthetic form of BH4, which acts as a cofactor in patients with residual PAH activity, is approved by the FDA to reduce phenylalanine levels in PKU.\xa0\nPreliminary trials with recombinant phenylalanine ammonia lyase have been encouraging and demonstrated reduced blood levels of phenylalanine during treatment.\xa0\n\nLab Diagnosis of PKU\nGuthrie\xa0Test (Bacterial Inhibition Assay of Guthrie).\n\nRapid screening test in the blood sample.\nFirst method used for this purpose.\n\n\xa0\nKey Concept:\nA low-phenylalanine diet, administration of large neutral amino acids (LNAAs)\xa0 and sapropterin dihydrochloride, all these comprise the treatment modalities for Phenylketonuria. Guthrie test is used for its rapid screening.\nReference-\xa0 Harper’s illustrated biochemistry. 30th edition page -304', 'role': 'assistant'}]