This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
[{'content': 'True statement about p53 are all except \nSelect and explain. \nA. It regulates ceain genes involved in cell cycle, B. Its increased levels can induce apoptosis, C. Its activity in cells decrease following UV radiation & stimulates cell cycle, D. Mutations in p53 are the MC genetic alterations seen in human cancer', 'role': 'user'}, {'content': 'Answer: C \nExplanation: TP53 Transcription factor; Has propeies of both an oncogene and a tumour suppressor gene Small arm of Chr 17 (17p13.1) Protein product: p53 "Guardian of the genome"; "molecular policeman"; critical gatekeeper Li Fraumeni syndrome - Hereditary loss an allele Ca lung, colon, breast LOF mutation of TP53 - MC mutation in >50% cancers', 'role': 'assistant'}]