This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General physiology, Subject name: Physiology
[{'content': 'About first order kinetics true statement is \nSelect and explain. \nA. Clearance remains constant, B. Fixed amount of the drug is eliminated, C. Half life increase with dose, D. Decreased clearance with increasing dose', 'role': 'user'}, {'content': 'Answer: A \nExplanation: I 1st order reaction half life remains constant and clearence remains constant In zero order reaction half life decrease with decrease in concentration Ref:Guyton and Hall textbook of medical physiology 12th edition,page number:489,490', 'role': 'assistant'}]