This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Nervous System, Subject name: Physiology
[{'content': 'Clonus is due to? \nSelect and explain. \nA. Upper motor neuron damage, B. Lower motor neuron damage, C. Extrapyramidal damage, D. Cerebellar damage', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. A Upper motor neuron damageRef: Ganong, 25th ed. pg. 233Clonus is characterized by repeated rhythmic contractions of muscle subjected to sudden maintained stretch.It is Caused by* Increased Gamma motor neuron discharge* Spinal cord injury causing damage to Renshaw cell which is an inhibitory inter-neuron.Conditions in Which Clonus is seen:1. Amyotrophic lateral sclerosis2. Stroke3. Multiple sclerosis4. Spinal cord damage5. Hepatic encephalopathyClonazepam and botulinum toxin is useful in management of clonus.', 'role': 'assistant'}]