This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Enzyme basics and serine proteases, Subject name: Biochemistry
[{'content': 'All of the following are examples for mechanism based inhibition, EXCEPT: \nSelect and explain. \nA. Aspirin on cyclooxygenase, B. Allopurinol on Xanthine oxidase, C. Statins on HMG-CoA reductase, D. Difluoromethylornithine on ornithine decarboxylase', 'role': 'user'}, {'content': "Answer: C \nExplanation: Mechanism-based inhibition/Suicidal inhibition: Suicidal inhibitors resemble the actual substrate of the enzyme. Enzymes binds to suicidal inhibitor & catalytic process is staed. In the process of catalysis, enzyme undergoes irreversible covalent modification by the inhibitor & active enzyme can't be regenerated. (Enzyme catalyses its own destruction) Suicidal Inhibitor Enzyme Allopurinol Xanthine oxidase Aspirin Cyclooxygenase 5-FU Thymidylate synthase Penicillin Transpeptidase Difluoromethylornithine Ornithine decarboxylase", 'role': 'assistant'}]