This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous (Gynae), Subject name: Gynaecology & Obstetrics
[{'content': 'Folic acid required in first trimester of normal pregnancy - \nSelect and explain. \nA. 100 microgram, B. 400 microgram, C. 4 mg, D. 5 mg', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e., 400 microgram * Some NTDs are associated with a specific mutation in the methylene tetrahydrofolate reductase gene, the adverse effects of which can be largely overcome by periconceptional folic acid supplementation.* More than half of NTDs could be prevented with daily intake of 400 pgm of folic acid throughout the periconceptional period.* A woman with a prior pregnancy complicated by a neural tube defect can reduce the 23% recurrence risk by more than 70% if she takes 4 mg of folic acid for the month before conception and for the first trimester of pregnancy.", 'role': 'assistant'}]