This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': "All of the following are true about nodular sclerosis of Hodgkin's disease except - \nSelect and explain. \nA. Well formed fibrous stands, B. CD 15 +, C. CD 20 +, D. Infiltration by plasma cells", 'role': 'user'}, {'content': 'Answer: C \nExplanation: CD 20 is positive in lymphocytic predominance variant (not in nodular sclerosis variant)\n\n\xa0Pathology of nodular sclerosing variant\n\nPresence of lacunar variant of Reed-sternberg cells.\nDeposition of collagen in bands that divide the involved lymph nodes into circumscribed nodules.\nFibrosis may be scant or abundant.\nThe Reed-Sternberg cells are found in a polymorphous background of T-cells, eosinophils, plasma cells and macrophages.\n\nFollowing information has been added in 8th \xa0of Robbins\n\nClassical Reed-Sternberg cells are also positive for PAX5 (a B-cell transcription factor) along with CD15 and CD30.', 'role': 'assistant'}]