This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'The phase I reactions of drug metabolism include the following except: \nSelect and explain. \nA. Hydrolysis, B. Reduction, C. Oxidation, D. Conjugation', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Biotransformation\xa0reactions can\xa0be classified\xa0into:\xa0\n\nNonsynthetic/Phase 1/Functionalization reactions:\n\t\xa0A\xa0 functional group (- OH, -COOH, -CHO, H2, - SH) is generated or exposed- metabolite may be active or inactive.\xa0\nSynthetic / Conjugation / Phase lI reactions:\xa0\n\tAn endogenous radical is conjugated to the drug- metabolite is mostly inactive; except few drugs,\xa0e.g. glucuronide conjugate of morphine and sulfate conjugate of minoxidil are active.\n\tCertain drugs already have functional groups and are directly conjugated, while others undergo a phase I reaction first followed by a phase II reaction.', 'role': 'assistant'}]