This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': "Mutation in the oxidative enzymes (peroxisomes) could lead to: \nSelect and explain. \nA. Zellweger's syndrome, B. Gaucher's disease, C. Epidermolysis bullosa, D. Leber's neuropathy", 'role': 'user'}, {'content': 'Answer: A \nExplanation: Most cases of zellweger syndrome are due to mutations in genes involved in the biogenesis of\xa0 peroxisomes.\nThis condition is apparent at birth and is characterized by profound neurologic impairment, victims\xa0 often dying within a year.\nThe number of peroxisomes can vary from being almost normal to being virtually absent in some\xa0 patients.\n\nKey Concept:\nMutation in peroxisomes can lead to Zellweger’s syndrome.\nRef : Harper’s illustrated biochemistry, 31st edition.', 'role': 'assistant'}]