This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'Non specific esterase in present in – \nSelect and explain. \nA. Megakaryocytic leukaemia, B. Lymphocytic leukaemia, C. Erythroleukaemia, D. AML', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Acute Myelogenous leukemia (AML)\n\nAML is a cancer of myeloid line of WBCs, characterized by the rapid proliferation of abnormal cells which accumulate in the bone marrow and interfere with the production of normal blood cells.\nAML is the most common acute leukemia affecting adults.\nThe diagnosis of AML is based on finding that myeloid blasts make up more than 20% of the cells in the marrow.\n\nMveloblasts are inyeloperoxidase (peroxidase) positive. \n\nAuer rods (Represent abnormal azurophilic granule) are also present in myeloblasts and their presence is taken to be definite evedence of myeloid differentiation.\nIn some AMLs, blast cells exhibit differentiation of other myeloid stem cell line (other than myeloblast), e.g.,\n\ni)\xa0\xa0Monoblast → Lack aver rods, peroxides negative, but nonspecific esterase positive.\nii). Megakaryocytic differentiation\niii) Erythroblast', 'role': 'assistant'}]