This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Not present in Sideroblastic anaemia is ? \nSelect and explain. \nA. Microcytic anaemia, B. Decreased transferrin saturation, C. Sideroblast cells in blood smear film, D. Ineffective erythropoesis', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e., Decreased transferrin saturation Sideroblastic anemia Sideroblastic anemia is a type of anemia in which the body has adequate amount of iron but is unable to corporate it into hemoglobin. Pathogensis o The basis defect is a failure to completely form heme molecules, whose biosynthesis takes place paly in the mitochondria. o The iron enters into the mitochondria, but cannot be utilized to synthesize heme. So iron, accumulates in mitochrondria giving a ringed appearance --> Ringed sideroblast. o Because these ringed sideroblastis can develop poorly or not at all into mature RBCs, anemia is a consequence.", 'role': 'assistant'}]