This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Physiology
[{'content': 'True about Hb dissociation curve: \nSelect and explain. \nA. Acidosis shifts O2 dissociation curve to right, B. Increased CO2 shifts the curve to left, C. Hypoxia shifts curve to left, D. 2,3 DPG has no effect on curve', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Oxygen-hemoglobin dissociation curve is shifted to right in the following conditions:\xa0\n\nDecrease in partial pressure of oxygen.\n\xa0Increase in partial pressure of carbon dioxide (Bohr effect).\nIncrease in hydrogen ion concentration and decrease in pH (acidity).\xa0\nIncreased body temperature.\xa0\nExcess of 2,3-diphosphoglycerate (DPG) in RBC. It is also called 2,3-biphosphoglycerate (BPG). DPG is a byproduct in Embden-Meyer-hof pathway of carbohydrate metabolism. It combines with β-chains of hemoglobin. In conditions like muscular exercise and in high attitude, the DPG increases in RBC. So, the oxygen-hemoglobin dissociation curve shifts to right to a great extent.', 'role': 'assistant'}]