This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.V.S, Subject name: Medicine
[{'content': 'Most common cardiac manifestation of Holt Oram syndrome is ? \nSelect and explain. \nA. ASD, B. VSD, C. tachycardia, D. PDA', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Holt-Oram syndrome (also called Hea and Hand Syndrome, atrio-digital syndrome, atriodigital dysplasia, cardiac-limb syndrome, hea-hand syndrome type 1, HOS, ventriculo-radial syndrome is an autosomal dominant disorder that affects bones in the arms and hands (the upper limbs) and may also cause hea problems. The syndrome includes an absent radial bone in the arms, an atrial septal defect , and a first degree hea block Ref Davidson 23rd edition pg 467', 'role': 'assistant'}]