This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunity, Subject name: Pathology
[{'content': 'During development, all the antigens of self are introduced to thymic cells in-order to be removed to prevent autoimmunity. Which of the following genes is involved in the process? \nSelect and explain. \nA. NOTCH1, B. AIRE, C. RB gene, D. CPK gene', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Ans. (b) AIRE(Ref: R 9/p 213)The process in the questions refers to Central tolerance, where the self reacting T cells are presented to the thymus to prevent autoimmunity. A protein called AIRE (autoimmune regulator) stimulates expression of few "peripheral tissue-restricted" self antigens in the thymus. This causes deletion of immature T cells specific for these antigens and so is able to prevent autoimmunity.', 'role': 'assistant'}]