This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Anatomy
[{'content': 'Fluconazole different from ketoconazole in that \nSelect and explain. \nA. It is not active by the oral route, B. It is more potent inhibitor of drug metabolism, C. It is not effective in Cryptococcal meningitis, D. It is unlikely to produce anti androgenic side effects', 'role': 'user'}, {'content': 'Answer: D \nExplanation: REF-KDT6/e p762) Ketoconazole is rarely used now a days because of several limitations. Impoant among them are: Poor oral bioavailability Limited CNS penetration Powerful inhibition of microsomal enzymes Anti-androgenic adverse effects like gynaecomastia Fluconazole is preferred agent because it has Very good oral absorption Maximum CNS penetration (therefore effective in cryptococcal meningitis). No inhibitorv action on microsomal enzymes No anti-androgenic propey.', 'role': 'assistant'}]