This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology and breast, Subject name: Surgery
[{'content': 'Treatment with herceptin in breast cancer is indicated for \nSelect and explain. \nA. ER receptor +ve tumours, B. PR receptor +ve tumours, C. K : 67 stain +ve tumours, D. Tumours with over-expressed C-erb B-2 protein', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Treatment with herceptin in breast cancer is indicated for Tumours with over-expressed C-erb B-2 protein it is a inhibitor of C-erb B-2 protein, which is a growth factor receptor also known as Transtuzumab it is currently approved by FDA for use only in metastatic disease ref ;(page no;551) 5th edition of SRB&;S Manual of SURGERY', 'role': 'assistant'}]