This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'A 5-year-old child suffering from nephrotic syndrome is responding well to steroid therapy. What would be the most likely finding on light microscopy – \nSelect and explain. \nA. No finding, B. Basement membrabne thicking, C. Hypercellular glomeruli, D. Fusion of foot processes', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Minimal change disease\n\nMinimal Change Disease is the most common cause of Nephrotic syndrome in children.\nOedema and Selective proteinuria are features of the nephrotic syndrome. Fever may be present on account of increased susceptibility to infection.\nMinimal change disease presents with insidious onset of nephrotic syndrome in children below 6 years of age.\nHypertension is not a feature of nephrOtic syndrome and is rare in Minimal change disease. Hematuria (a finding of the nephritic syndrome) is also rare.\n\nPathological findings include\n\nLight microscopy → No abnormality\nElectron microscopy →Obliteration (loss) and fusion of foot processes of epithelial cells.\nImmunofluorescence → No deposits of immune reactants\nSerum complements → Normal levels\n\n\nMinimal change disease has a very good prognosis with excellent response to steroids.', 'role': 'assistant'}]