This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
[{'content': 'Most common type of human papilloma virus causing Ca cervix are: \nSelect and explain. \nA. 16 and 18, B. 1 and 33, C. 6 and 11, D. 2 and 14', 'role': 'user'}, {'content': 'Answer: A \nExplanation: It is now established that HPV plays a major role in cervical carcinogenesis.\nAmong the various genotypes (more than 100) the Genotype of HPV which is:\n\nMost commonly associated with squamous cell carcinoma cervix\xa0- HPV 16\nMost common genotype associated with adenocarcinoma of cervix - HPV 18\nOverall MC genotype associated with invasive carcinoma, CIN II and CIN III\xa0- HPV 16\nBut HPV 16 is not very specific as it is seen in 16% of women with low grade lesion and 14% women with normal cytology so: -\xa0HPV 18\nMost specific genotype of HPV for invasive tumor \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0\xa0\nThe cytological changes caused by HPV are collectively called as Koilocytosis.\nIn most of the females HPV infection clears in 9-15 months , only in small minority it persists.\nMalignant transformation requires expression of E6 and E7 HPV oncoproteins.', 'role': 'assistant'}]