This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': 'Hyperkeratosis of palm and sole is seen in: \nSelect and explain. \nA. Carcinoma colon, B. Hepatoma, C. Adenocarcinoma lung, D. Ca oesophagus', 'role': 'user'}, {'content': "Answer: D \nExplanation: Answer is D (Ca Esophagus) Congenital hyperkeratosis and pitting of palms and soles (Le tylosis palmaris et plantaris) is a known etiological factor for squamous Ca of Esophagus' - Harrison", 'role': 'assistant'}]