This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'Henoch schonlein purpura is characterized by deposition of which of the following antibodies in the blood vessels? \nSelect and explain. \nA. IgA, B. IgG, C. IgD, D. IgM', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Henoch-Schonlein purpura\n\nHenoch - Schonlein purpura is vasculitis of small vessels (capillaries, venule or arterioles) and characterized by deposition of IgA in the wall of involved vessels.\nH.S. purpura is characterized by a tetrad of purpura, arthritis, glomerulonephritis, and abdominal pain. Gross hematuria is seen in 20-30% of cases.\nAll changes resulting from the deposition of circulating immune complexes, containing IgA and complement on the endothelium of the blood vessels throughout the body and within the glomerular mesangial regions.\nDiagnosis is confirmed by the presence of palpable purpura with normal platelet count along with one or more of the following: abdominal pain, arthralgia/arthritis and mesangial deposition of IgA.\nRenal manifestations usually start at the onset or within 3 months of onset of other symptoms', 'role': 'assistant'}]