This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Antidote for organophosphorous poisoning is ? \nSelect and explain. \nA. Atropine, B. Neostigmine, C. Succinylcholine, D. D-Tubocurarine', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Atropine Pharmacological treatment of organonhosphatepoisoning Atropine o Atropine is the mainstay of treatment (antidote of choice). o Atropine antagonizes the muscarinic parasympathetic effects of organophosphate (excessive secretion and vasodilation), but does not antagonize nicotinic effects, i.e., neuramuscular blockers (Atropine blocks muscarinic receptors, i.e., it is an antimuscarinic) o Atropine antagonizes both peripheral as well as central nervous system effects of organophosphates. Cholinesterase regenerator compounds (oximes) o Pralidoxime is most commonly used oxime. o Unlike atropine, they antagonize both muscarinic and nicotinic effects. o They antagonize only peripheral effects, but not central effects except for diacetylmonoxime (DAM) which crosses BBB and antagonizes central effects also.", 'role': 'assistant'}]