This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Which of the following factors has maximum effect on filtration of a drug by the glomerulus ? \nSelect and explain. \nA. Lipid solubility, B. Plasma protein binding, C. Degree of ionization, D. Rate of tubular secretion', 'role': 'user'}, {'content': 'Answer: B \nExplanation: -\xa0Main Factors determining glomerular filtration\n\n\xa0 \xa0Renal blood flow\n\xa0 \xa0Plasma protein binding\n\n-\xa0Lipid solubility does not affect glomerular filtration.\n-\xa0Ionization determines tubular reabsorption.\xa0\n-\xa0Tubular secretion happens after glomerular filtration and so does not affect the process.', 'role': 'assistant'}]