This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: miscellaneous, Subject name: Biochemistry
[{'content': 'A genetic disorder renders fructose 1,6 -- biphosphatase in liver less sensitive to regulation by fructose 2,6 -- bi-phosphate. All of the following metabolic changes are observed in this disorder except \nSelect and explain. \nA. Level of fructose 1,6--biphosphate is higher than normal, B. Level of fructose 1,6 -- biphosphate is lower than normal, C. Less pyruvate is formed, D. Less ATP is generated', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Fructose 2,6 - biphosphate acts to decrease the activity of fructose 1,6 - biphosphatase. When the enzyme becomes less sensitive to regulation, the inhibitory effect is lost and the enzyme activity increases. The following effects are observed:1. Level of fructose 1,6 -- biphosphate decreases2. Pyruvate is used up for glucose synthesis3. ATP is used up for glucose synthesis Reference: Harpers illustrated biochemistry 30th edition', 'role': 'assistant'}]