This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
[{'content': 'In minimal change disease following is not seen - \nSelect and explain. \nA. Massive proteinuria, B. Normal electron microscopic appearance, C. Light microscopy normal, D. Good response to steroids', 'role': 'user'}, {'content': 'Answer: B \nExplanation: (B) (Normal electron microscopic appearance) (650- Harshmohan 7th)Minimal change disease (910-Rabbins pathologic of Basis of disease)Most frequent clinical presentationNephritic syndrome ** (selectiveproteinuria)PathogenesisUnknown; loss of glomerular polyanion podocyte injuryLight microscopyNormal; lipid in tubulesFluoroscence microscopyNegativeElectron microscopyLoss of foot processes, no depositsMINIMAL CHANGE DISEASE (MED)*Relatively benign disorder is characterized by uniform and diffuse effacement offoot processes of visceral epithelialcell (podocyte), detectable only by electron microscopy in glomeruli that appear virtually normal by light microscopy.*Most frequent cause of nephritic syndrome in children (between 2 and 6 years). The disease sometimes follows a respiratory infection or routine prophylactic immunization.*A characteristic feature its usually dramatic response to corticosteroid therapy.*MCD in adults can be associated with Hodgkin lymphoma and less frequently other lymphomas and leukemias.*In addition secondary MCD may follow NSAID therapy, usually in associated with acute interstitial nephritis.*Hyper coagulation in Nephrotic syndrome is causes by loss of antithrombin III ***Most common fixative used in electron microscopy -formalin**Fixative used in histopathology - 10% buffered neutral formalin', 'role': 'assistant'}]