This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
[{'content': 'Auditory toxicity is maximum with: \nSelect and explain. \nA. Streptomycin, B. Kanamycin, C. Tobramycin, D. Amikacin', 'role': 'user'}, {'content': 'Answer: D \nExplanation: AMIKACIN: It is a semisynthetic derivative of kanamycin tc which it resembles in pharmacokinetics, dose anc toxicity. The outstanding feature of amikacin is its resistance to bacterial aminoglycoside inactvating enzymes. Thus, it has the widest spectrurr of activity, including many organisms resistan: to other aminoglycosides. However, relatiwh higher doses are needed for Pseudomonas, Prot c. ....', 'role': 'assistant'}]