This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Colon and Rectum - Polyps and Carcinoma, Subject name: Surgery
[{'content': 'Based on Epidemiological studies, which of the following has been found to be most protective against carcinoma colon? \nSelect and explain. \nA. High fiber diet, B. Low fat diet, C. Low selenium diet, D. Low protein diet', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. a. High fiber diet Based on epidemiological studies, high fiber diet has been found to be most protective against carcinoma colon."High fiber diet has been found to have protective effect by increasing the stool bulk, diluting the toxins, and reducing the colonic transit time and thus reducing exposure time to fecal carcinogens."Risk Factors for the Development of Colorectal Cancer1. Dietary Factors:- High animal fat diet- Low fiber diet- Alcohol2. Hereditary syndromes:- FAP- HNPCC3. Inflammatory bowel disease (Both UC and Crohn\'s disease)4. Streptococcus bovis bacteremia05. Ureterosigmoidostomy6. Smoking7. Acromegaly8. Pelvic irradiationChemoprevention* There is significant chemopreventive role of INSAIDs, Calcium carbonate. Selenium and Hormone replacement therapy in colorectal neoplasia0.', 'role': 'assistant'}]