This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
[{'content': 'Which part of bacteria is most antigenic- \nSelect and explain. \nA. Protein coat, B. Lipopolysaccharide, C. Nucleic acid, D. Lipids', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Proteins are most immunogenic, while lipids & nucleic acids arc least immunogenic.\nPolysaccharides (carbohydrates) are less immunogenic than protein antigens, but are more antigenic than lipids &nucleic acids.\n\xa0\nDeterminants of antigenicity\nA number of properties of antigen determine its antigenicity (production of antibody or induction of cell mediated immunity):\n\xa0\nChemical nature\nProteins > Polysaccharide > lipids and nucleic acids.\nAll proteins except gelatin arc immunogenic.\n\xa0\nSize\nHigh molecular weight particles > low molecular weight particles.\n\xa0\nForeign ness\nIn general, molecules recognized as "self are not immunogenic; for immunogenicity, molecules must be recognized as "nonself".\n\xa0\nSusceptibility to tissue enzymes\nOnly substances which are metabolized and are susceptible to the action of tissue enzymes behave as antigens.\n\xa0\nRoute of administration\nParenteral > oral', 'role': 'assistant'}]