This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'True statement about clonidine are all except ? \nSelect and explain. \nA. Increases parasympathetic outflow, B. Decreases sympathetic outflow by blocking central alpha receptor, C. Used in hypeension, D. Prazosin is used to antagonize side effects of clonidine', 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans. is 'd' i.e., Prazosin is used to antagonize side effects of clonidine Clonidine is an a-2 agonist, while prazosin blocks the a-1 receptors. o Clonidine enhances vagal tone (parasympathetic outflow) which can cause bradycardia. o The major haemodynamic effects result from stimulation of a2a receptors present mainly postjunctionally in medulla --> decrease sympathetic outflow --> fall in BP and bradycardia. o Clonidine is used in hypeension.", 'role': 'assistant'}]