This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Wilms Tumor, Subject name: Pathology
[{'content': "In Wilm's tumor the following leads to emergence of resistance to chemotherapy: \nSelect and explain. \nA. Nephrogenic rests, B. Monophasic morphology, C. Anaplasia, D. Capsular infiltration", 'role': 'user'}, {'content': "Answer: C \nExplanation: Wilm's tumor : 5% of tumors reveal anaplasia- Large, hyperchromatic, pleomorphic nuclei and abnormal mitoses . The presence of anaplasia correlates with underlying p53 mutation -Emergence of resistance to chemotherapy.", 'role': 'assistant'}]