This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy: General Principles, Subject name: Pharmacology
[{'content': 'Which of the followign drugs require dose adjustment in renal failure? \nSelect and explain. \nA. Cefoperazone, B. Doxycycline, C. Streptomycin, D. Rifampicin', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ans. (C) Streptomycin(Ref: Katzung 10/e p835 KDT 8/e p746)Streptomycin is an aminoglycoside and require dose adjustment in renal failure whereas doxycycline, rifampicin and cefoperazone are secreted in bile and do not require dose adjustment in renal failure.', 'role': 'assistant'}]