This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General Pharmacology, Subject name: Pharmacology
[{'content': 'Loading dose of a drug depends upon: \nSelect and explain. \nA. Volume of distribution, B. Clearance, C. Half life, D. Duration of action', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. (A) Volume of distribution(Ref: KDT 8th/41)Loading dose: It is mainly used for drugs having long t1/2 and large volume of distribution. It is given to load (saturate) the tissue stores. So it is mainly dependent on Vd.Loading dose = VD x Target plasma concentrationMaintenance dose: It is mainly dependent on CL.Maintenance dose = CL x Target plasma concentration', 'role': 'assistant'}]