This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': 'Which one of the following is true regarding HIV infection? \nSelect and explain. \nA. Following needle stick injury, infectivity is reduced by administration of nucleoside analogues, B. CD4 counts are the best predictors of disease progression, C. Infected T cells survive for a month in infected patients, D. In latent phase, HIV has minimal replication', 'role': 'user'}, {'content': 'Answer: A \nExplanation: “Four week treatment with AZT monotherapy after needle stick exposure to HIV among health care worker decreases the chance of becoming\xa0infected by 79%.”\nGuideliness for post exposure prophylaxis:\n\nA combination of two nucleoside analogue reverse transcriptase inhibitors for 4 weeks for less severe exposures.\nA combination of two nucleoside analogue\xa0RT inhibitor plus a third drug given for 4 weeks for more severe exposure.\n\nFactors associated with increased risk of occupational transmission:\n\nDeep injury.\nPresence of visible blood on the instrument causing the exposure.\nInjury with the device that has been placed in vein or artery of source patient.\nTerminal illness of source patient.\nLack of post exposure antiretroviral therapy in exposed health worker.\n\n- Best Predictor to disease progression is HIV RNA estimation, not CD4+ count.\n- CD4+ count are the best indicator of immediate state of immunologic competence.\nSo, option ‘2’ is wrong.\nClinical latency versus microbial latency.\nClinical latency should not be confused with microbial latency, since virus replication is present in most patient.', 'role': 'assistant'}]