This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Anatomy
[{'content': 'Which of the following provides the best explanation for neostigmine being preferred over physostigmine for treating Myasthenia gravis \nSelect and explain. \nA. It is better absorbed orally, B. It has longer duration of action, C. It is the additional direct on agonistic action on nicotinic receptor in the muscle end plate, D. It Penetrates blood brain barrier', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ref-KDT 6/e p103 Neostigmine is a quaternary ammonium derivative and is lipid insoluble. Its absorption from GIT penetration in the brain and cornea is much less than physostigmine . It produces additional action on NM receptor', 'role': 'assistant'}]