This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Urinary tract, Subject name: Pathology
[{'content': 'First pathological change apparent in Nephrotic syndrome is \nSelect and explain. \nA. Thickening of the glomerular capillary wall and effacement of podocyte foot processes, B. Segmental sclerosis of glomerulus, C. Break in basement membrane, D. Mononuclear infiltration', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Most forms of primary GN and many of the secondary glomerular diseases in human beings have immunologic pathogenesis. This view is largely based on immunofluorescence studies of GN in humans which have revealed glomerular deposits of immunoglobulins and complement in patterns that closely resemble those of experimental models. The consequences of injury at different sites within the glomerulus in various glomerular diseases can be assessed when compared with the normal physiologic role of the main cells involved i.e. endothelial, mesangial, visceral epithelial, and parietal epithelial cells as well as of the GBM as summed up in Table 22.8.<\\p> text book of pathology harshmohan 6th edition page 662', 'role': 'assistant'}]