This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cardiovascular system, Subject name: Pharmacology
[{'content': 'Digoxin action is not affected in \nSelect and explain. \nA. Hepatic disease, B. Electrolyte disturbances, C. Renal failure, D. MI', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ref-KDT 5/e p463 Digoxin is eliminated mainly excretion through kidney. Dose of big ox and therefore does not require adjustment in hepatic failure where as it has to be reduced in renal failure', 'role': 'assistant'}]