This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of carbohydrate, Subject name: Biochemistry
[{'content': 'which requires thiamine pyrophosphate as the cofactor in HMP pathway? \nSelect and explain. \nA. Phosphogluconate dehydrogenase, B. Glucose 6 PO4 dehydrogenase, C. Transaldolase, D. Transketolase', 'role': 'user'}, {'content': "Answer: D \nExplanation: Transketolase catalyzes the transfer of a two-carbon unit from xylulose5-phosphate to ribose-5-phosphate, producing the seven-carbon ketose sedoheptulose-7-phosphate and the aldose glyceraldehyde-3-phosphate. ThusThis reaction requires two coenzymes:(a) Mg2+ (b)Thiamine diphosphate (vitamin B1) Measurement of erythrocyte transketolase and its activation by thiamine pyrophosphate provides an index of vitamin B1 nutritional status. Reference: Harper's Illustrated Biochemistry 31stedition Page nos 183-185", 'role': 'assistant'}]