This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Which of the following is a major complication of chronic bronchitis? \nSelect and explain. \nA. Myxedema, B. Pneumothorax, C. Emphysema, D. Malignant transformation', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Chronic bronchitis predisposes those affected to squamous neoplasia of the bronchial epithelium (i.e., bronchogenic carcinoma).', 'role': 'assistant'}]