This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Seedatives & Hyponotics, Subject name: Pharmacology
[{'content': 'In which of the following disorders, administration of barbiturates is contraindicated? \nSelect and explain. \nA. Anxiety disorders, B. Acute intermittent porphyria, C. Kernicterus, D. Refractory status epilepticus', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. (B) Acute intermittent porphyria(Ref: KDT 8/e p427)Barbiturates induce the rate limiting enzyme 'd-aminolaevulanic acid synthase' in porphyrin synthesis. This increased synthesis of porphyrins can precipitate acute attack of AIP.", 'role': 'assistant'}]