This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Which of the following statement regarding first order kinetics is true? \nSelect and explain. \nA. It is independent of plasma concentration, B. Tl/2 of the drug increases with dose, C. Clearance of the drug decreases with dose, D. A constant propoion of plasma concentration is eliminated', 'role': 'user'}, {'content': 'Answer: D \nExplanation: According to first order kinetics of elimination the rate of elimination of a drug is directly propotional to the drug concentration. Clearence of the drug remains constant and a constant fraction of drug is eliminated in unit time. Ref: Essentials of Medical Pharmacology By KD Tripathi, 5th Edition, Page 27-8', 'role': 'assistant'}]