This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Pharmacology
[{'content': 'Which of the following drugs is most effective against an organism producing aminoglycoside inactivating enzymes? \nSelect and explain. \nA. Amikacin, B. Streptomycin, C. Gentamicin, D. Tobramycin', 'role': 'user'}, {'content': 'Answer: A \nExplanation: (Ref: KDT 6/e p724) Amikacin is most resistant to aminoglycoside inactivating enzymes. Aminoglycosides are not effective against anaerobes.', 'role': 'assistant'}]