This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
[{'content': 'Which of the following drugs require dose adjustment in renal failure \nSelect and explain. \nA. Cefoperazone, B. Doxycycline, C. Streptomycin, D. Rifamipicin', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ref Katzung 10/r p 835 Streptomycin is an aminoglycoside and require dose adjustment in renal failure whereas Doxycycline, Rifampicin and cefoperazone are secreted in bile and do not require dose adjustment in renal failure', 'role': 'assistant'}]