This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy: General Principles, Subject name: Pharmacology
[{'content': 'True statement regarding development of drug resistance in MRSA is: \nSelect and explain. \nA. Results due to penicillinase enzyme production, B. Occurs due to change in penicillin-binding proteins, C. Chromosome mediated, D. Treated with amoxicillin + clavulanic acid', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. (B) Occurs due to change in penicillin-binding proteins(Ref: Katzung's 11/e p776, KDT 8/e p743)Methicillin resistance occurs due to altered PBPs, thus no penicillin, (infact no beta-lactam antibiotic) is useful against methicillin-resistant Staphylococcus aureus (MRSA) infections.", 'role': 'assistant'}]