This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'Bile salts undergo xenobiotics: \nSelect and explain. \nA. After conjugation with taurine and glycine, B. After conjugation with lysine, C. After conjugation with betaglucuronic acid, D. After conjugation with derived proteins', 'role': 'user'}, {'content': 'Answer: C \nExplanation: C i.e. Conjugation with betaglucuronic acid- Phase I biotransformation reactions include Hydrolysis, Hydroxylation, Reduction, Oxidation, Oxidative Deamination, Dealkaylation and Epioxidation. Mn "High RODE". Whereas phase II reactions include Glucronidation, Sulfation, Conjugation (with glucronic acid, glutathione, sulfate or aminoacids), Acetylation and Methylation. Mn "5G-SCAM".Cytochrome p450 monoxygenase is the main enzyme responsible for activation of xenobiotics (phase I hydroxylation reaction)Q.Bilirubin is metabolized like xenobiotics; it is conjugated with beta glucronic acid in hepatocytes to conve a nonpolar hydrophobic bilirubin to a polar hydrophilic one which is readily excreted in bileQ.', 'role': 'assistant'}]