This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunology, Subject name: Microbiology
[{'content': 'Type I hypersensitivity, the mediator is - \nSelect and explain. \nA. IgE, B. IgD, C. IgM, D. IgC', 'role': 'user'}, {'content': "Answer: A \nExplanation: Type I hypersensitivity reaction is IgE dependent. Cytotoxic IgE antibodies are fixed on the surface of tissue cells ( mast cells and basophils) in sensitized individuals. The antigen combines with the cell fixed antibody, leading to release of pharmacologically active substance that produces the clinical reaction. Reference : Anathanarayan & paniker's 9th edition, pg: 162 <\\p>", 'role': 'assistant'}]