This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Medicine
[{'content': 'In renal disease, Albumin is first to appear In urine because- \nSelect and explain. \nA. Hyaline cast, B. Coarse granular cast, C. Broad cast, D. Epithelial cast', 'role': 'user'}, {'content': 'Answer: C \nExplanation: In renal disease,comosition of Glomerular basement membrane is altered notably with loss of heparan sulfate moieties that form negatively charged filtration barrier(prevents loss of negatively charged serum protiens due to repulsion) This results in increased filtration of serum protiens into the urine predominantly negatively charged albumin. Ref:Harrison 20th edition pg no. 2144', 'role': 'assistant'}]