This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Nephrotic Syndrome, Subject name: Pathology
[{'content': 'Finnish type of nephrotic syndrome is associated with mutations of which of the following? \nSelect and explain. \nA. Nephrin, B. Podocin, C. Alpha actinin, D. CD2 activated protein', 'role': 'user'}, {'content': 'Answer: A \nExplanation: NPHS1 gene mutations = Congenital nephrotic syndrome of the Finnish type, producing a minimal-change disease like glomerulopathy with extensive foot process effacement. NPHS1 is located on chromosome 19q13 and encodes the protein nephrin.', 'role': 'assistant'}]