This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'All are true about warfarin, except: \nSelect and explain. \nA. It inhibits the activation of vitamin K dependent clotting factors, B. Its half life is 36 hours, C. It can cross placenta, D. Its dose is increased in liver disease', 'role': 'user'}, {'content': "Answer: D \nExplanation: Warfarin is an oral anticoagulant that acts by inhibiting the γ- carboxylation of glutamate residues in vitamin-K de\xadpendent clotting factors (II, VII, IX and X).\nIt has 99% binding to albumin that result in.\nLong half-life (t1/2 = 36 hours).\nSmall volume of distribution.\nLack of urinary excretion of unchanged drug.\nIt readily crosses the placenta. If given during pregnancy, it can result in 'Contradi syndrome' in the fetus.\nThe liver disease reduces the synthesis of clotting factors, thus increases the effect of warfarin. The dose of this drug, therefore, needs to be reduced in liver disease.", 'role': 'assistant'}]