This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'True about ALL – \nSelect and explain. \nA. Anemia, B. Leukopenia, C. Hepatomegaly, D. All of the above', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Clinical manifestations of ALL \n\nSymptoms related to depression of normal marrow function.\nAn accumulation of neoplastic blast cells in the bone marrow suppresses normal hematopoiesis by physical crowding and competition for growth factors.\nThis results in : -\n\nAnemia → Fatigue, pallor\nNeutropenia→Infection, fever\nThrotnbocytopenia → Bleeding, petechiae, ecchymoses, epistaxis.\n\nThese are the most common sign & symptoms.\n\nBone pain and tenderness\n\nResulting from marrow expansion and infiltration of the subperiosteum.\n\nGeneralized lymphadenopathy, splenomegaly and hepatomegaly\n\nCaused by neoplastic infiltration of these tissues.\nMore common in ALL than AML.\n\nSymptoms related to compression of large mediastinal vessels or airway\n\nIn Pre-T ALL of thymus.\n\nCNS manifestation\n\nDue to meningeal involvement.\nA headache, vomiting, nerve palsies.\nMore common in ALL than in AML.\n\nTesticular involvement is also more common in ALL than in AML', 'role': 'assistant'}]