This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Major contribution to cachexia with advanced cancer? \nSelect and explain. \nA. Clathrin, B. Histamine, C. Interferon, D. Tumor-necrosis-factor (TNT)', 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans. is 'd' i.e., Turnor-necrosis factor (TNT) Patients with cancer commonly suffer progressive loss of body fat which is accompnied by profound weakness anorexia, and anemia. This wasting syndrome is referred to as cachexia. o TNF produced by macrophages or some tumor cells is the most impoant mediator of cachexia.", 'role': 'assistant'}]