This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'MOST common mutation seen in heriditary hemochromatosis is: \nSelect and explain. \nA. C282Y, B. H63D, C. TFR2, D. SLC11A3', 'role': 'user'}, {'content': 'Answer: A \nExplanation: The most common mutation in hereditary hemochromatos is a homozygous G to A mutation resulting in a cysteine to tyrosine substitution at position 282 (C282Y). Another relatively common mutation (H63D) results in a substitution of histidine to aspaic acid at codon 63. Mutations like transferrin receptor 2 TFR2 mutation and ferropoin 1 gene, SLC11A3 mutation are rare. Ref: Harrisons principles of internal medicine, 18th edition, Page: 3162', 'role': 'assistant'}]