This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Invasive squamous cell carcinoma is differentiated from carcinoma in situ by: \nSelect and explain. \nA. Penetration of basement membrane, B. Number of mitotic figures, C. Increased in size of cell, D. Nuclear pleomorphism', 'role': 'user'}, {'content': 'Answer: A \nExplanation: None', 'role': 'assistant'}]