This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous General Anesthesia, Subject name: Anaesthesia
[{'content': 'Which anesthetic is contraindicated in renal failure- \nSelect and explain. \nA. Isoflurane, B. Desflurane, C. Halothane, D. Methoxyflurane', 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans. is 'd' i.e., Methoxyflurane Methoxyflurane o It was most potent inhalation agent (least MAC), but is not used (now Halothane is most potent), o It should not be used in a closed circuit (reacts with rubber tubing of the closed circuit). o It has slowest onset & recovery (however now ether has slowest onset & recovery as methoxyflurane is not used), o The boiling point is more than water (104degC). o Intrarenal metabolism of methoxyflurane and subsequent intrarenal production of fluoride ion is the significant cause of methoxyflurane renal toxicity, o It can cause high output renal failure and hepatotoxicity.", 'role': 'assistant'}]