This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Skin
[{'content': 'Granular layer is absent in: \nSelect and explain. \nA. Ichtyosis vugaris, B. X linked ichthyosis, C. Epidermolytic hyper keratosis, D. Lamellar ichthyosis', 'role': 'user'}, {'content': 'Answer: A \nExplanation: A i.e. Ichtyosis vugaris Icthyosis vulgaris - Icthyosis vulgaris is autosomal dominant disorderQ, occurring due to reduced or absence of filaggrin protein and granular layerQ. It presents with dry scaly skin resembling fish (reptile or crocodile) skin K/a sauroderma. AD means one parent should also manifest disease. It is a congenital condition which is not present at bih but develops during first year of life. - Diy looking large mosaic like scales most commonly over anterior (extensor) surface of legs. Major flexors (axillae, groins, popliteal & cubital fossa) are always and face is usually spared; though cheeks & forehead may be rarely involved. Condition improves in humid & summers and deteriorates in winter. It may be associated with atopic diathesis, keratosis pilaris, hyper linear & exaggerated palm & sole creases, and occasionally, keratoderma.', 'role': 'assistant'}]