This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hea failure, Subject name: Medicine
[{'content': 'Which of the following is effective in management of patients of hea failure with preserved ejection fraction? \nSelect and explain. \nA. Digoxin, B. ARB with neprilysin inhibitor, C. Isosorbide mononitrate, D. Phosphodiesterase inhibitor', 'role': 'user'}, {'content': 'Answer: B \nExplanation: HFpEF (hea failure with preserved ejection fraction)- A.R.N.I (ARB & Nephrilysin inhibitor) HFrEF (hea failure with reduced ejection fraction)- ACE inhibitor+ Beta Blocker Phosphodiesterase inhibitor: RELAX trial- no improvement in functional capacity, quality of life (QOL), or other clinical and surrogate parameters in patients with HFpEF. Isosorbide mononitrate: (NEAT-HFpEF) trial- no improvement in QOL or submaximal exercise capacity in patients with HFpEF Digoxin Digitalis Investigation Group (DIG) found no role for digoxin in the treatment of HFpEF.', 'role': 'assistant'}]