This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Pharmacology
[{'content': 'Furosemide acts to inhibit Na + reabsorption in which of the following locations \nSelect and explain. \nA. Descending limb of the loop of Henle, B. Distal convoluted tubule, C. Collecting duct, D. Ascending limb of the loop of Henle', 'role': 'user'}, {'content': 'Answer: D \nExplanation: HIGH CEILING (LOOP) DIURETICS (Inhibitors of Na+ K+ 2Cl- Cotranspo) Furosemide (Frusemide):- The major site of action is the thick AscLH (therefore called loop diuretics) where furosemide inhibits Na+- K+-2Cl- cotranspo. A minor component of action on PT has also been indicated. It is secreted in PT by organic anion transpo and reaches AscLH where it acts from lluminal side of the membrane. Ref:- kd tripathi; pg num:-579', 'role': 'assistant'}]