This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'A 50 year old woman, Hema has been diagnosed with locally advanced breast cancer and recommended for chemotherapy. She has five years history of myocardial infarction and congestive heart failure. Which antineoplastic drug should be best avoided \nSelect and explain. \nA. Anthracycline, B. Alkylating agent, C. Platinum compound, D. Bisphosphonates', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Anthracyclines like Doxorubicin, Daunorubicin, Idarubicin and Epirubicin are implicated in causing cardiotoxicity. This adverse effect is due to the generation of iron mediated free radicals. Dexrazoxane is a free radical scavenger that can be used to prevent cardiotoxicity due to anthracyclines.', 'role': 'assistant'}]