This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Anaphylactic reaction caused by NSAIDs, all are true, except ? \nSelect and explain. \nA. Caused by All NSAIDs, B. COX-2 inhibitors are safe, C. Related to hypersensitivity reaction, D. Not related to inhibition of COX', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e., COX-2 inhibitors are safe(Ref: Clinical pharmacology 3d/e p.786)Anaphylactic reaction (anaphylaxis)It is dre to immediate (type-L) hypersensitivity involving cross linking of drug-specific IgE.Regardless of COX selectivity pattern, NSAIDs may function as haptens capable of inducing allergic sensitization.Thus, all COX inhibitors (nonselective or selective) can cause this reaction.", 'role': 'assistant'}]