This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Polycystic Ovarian Syndrome, Subject name: Gynaecology & Obstetrics
[{'content': 'What is TRUE about clomiphene? \nSelect and explain. \nA. Enclomiphene is anti-estrogenic, B. Pregnancy rate is comparable to placebo, C. Significantly increases sperm counts in oligospermic men, D. 1 - 2% increase in rate of twin pregnancy', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Clomiphene citrate Trans enclomiphene 62%: anti-estrogenic Cis zuclomiphene citrate 38% : mildly estrogenic This Primarily acts at the receptor in Hypothalamus rather than the Ovarian and Pituitary axis. Blockade increases the stimulus to the pituitary to produce more FSH. -Antagonises the beneficial actions of estrogens on the endometrium and hence a supplementation of estrogen is required in patients on higher doses of clomiphene for ovulation induction -6-12% increase in rate of twins Oligospermia relief is not the best benefit of Clomiphene...statistically, because roughly 10-15% only are benefited with this in oligospermia reversal.', 'role': 'assistant'}]