This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Vitamins and Minerals, Subject name: Biochemistry
[{'content': 'Which of the following deficiency can cause generalized oedema: \nSelect and explain. \nA. Vitamin B2, B. Vitamin B6, C. Vitamin B12, D. Vitamin B1', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Vitamin B1 deficiency is Beri-Beri, which can cause oedema in "Wet Beri-Beri" which affects CVS, leading to cardiac failure, pulmonary & peripheral oedema. Other clinical manifestations of Beri-Beri:', 'role': 'assistant'}]