This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cytogenetic Disorders, Subject name: Pathology
[{'content': 'All are familial breast cancer gene is all EXCEPT? \nSelect and explain. \nA. BRCA1, B. P53, C. P16, D. PTEN', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ans. (C) P16Ref: Robbiris pathology 9th ed. /1054-55* Genes called BRCA1, BRCA2, TP53 or PTEN are linked with breast cancer.* P16 plays an important role in cell cycle regulation by decelerating cells progression from G1 phase to S phase, and therefore acts as a tumor suppressor that is implicated in the prevention of cancers, notably melanoma, oropharyngeal squamous cell carcinoma, cervical cancer, and esophageal cancer.', 'role': 'assistant'}]