This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Sedative-Hypnotics and Parkinsonism, Subject name: Pharmacology
[{'content': 'In which of the following disorders is administration of barbiturates contraindicated in \nSelect and explain. \nA. Anxiety disorders, B. Acute intermittent porphyria, C. Kernicterus, D. Refractory status epilepticus', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Contraindications of barbiturates: Acute intermittent porphyria- Barbiturates exacerbate it by inducing microsomal enzymes (d aminolevulinic acid synthetase) and increasing porphyrin synthesis. Liver and kidney disease Severe pulmonary insufficiency e.g. emphysema Obstructive sleep apnoea Uses of barbiturates: Anxiety disorders Epilepsy Kernicterus / Congenital nonhemolytic jaundice : Phenobarbitone induces conjugation of bilirubin and hastens clearance of jaundice.', 'role': 'assistant'}]