This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Which of these genes promote epithelial-mesenchymal transition and are important metastatic genes in epithelial tumors? \nSelect and explain. \nA. MYC, B. SNAIL, C. TWIST, D. Both 2 and 3', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Metasis oncogenes are SNAIL\xa0and\xa0TWIST, which encode\xa0transcription\xa0factors\xa0whose\xa0primary function\xa0is\xa0to\xa0promote\xa0epithelial-to-mesenchymal\xa0transition (EMT).\xa0\nIn EMT, carcinoma cells downregulate certain epithelial markers (e.g., E-cadherin) and upregulate certain mesenchymal\xa0markers\xa0 (e.g.,\xa0 vimentin, smooth\xa0muscle actin).\nEMT has been documented mainly in breast carcinoma.\n\nReference-Robbins BASIC PATHOLOGY 10th edition pg-223', 'role': 'assistant'}]