This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
[{'content': "Not true about gynecomastia is \nSelect and explain. \nA. Can be drug induced, B. Klinefelter's syndrome, C. Seen in cryptoorchidism, D. None of the above", 'role': 'user'}, {'content': 'Answer: D \nExplanation: Gynaecomastia is hypertrophy of male breast more than usual due to increase in ductal (epithelial) and connective tissue (stromal)\xa0elements often attaining features of the female breast.\xa0\nIt can be unilateral or bilateral. Bilateral can be symmetrical or\xa0asymmetrical.\nEtiology is\xa0\nOestrogen excess—increased estradiol secretion due to a testicular tumour (Leydig cell) or nontesticular tumours from the adrenal cortex, lung, liver; hyperthyroidism (increases\xa0conversion of androgen to estrogen), liver diseases, oestrogen therapy for prostate cancer.\nAndrogen deficiency—aging, Klinefelter’s/Kallmann syndromes, a eunuch, ACTH deficiency.\xa0\nSecondary testicular failure—cryptorchidism, orchitis,\xa0trauma, CRF, etc.\xa0\nDrugs (25%): Increases estrogen activity (digitalis, anabolic steroid)/estrogen synthesis (reserpine, theophylline, frusemide).\xa0\xa0\nInhibition of testosterone synthesis—cimetidine, phenytoin, spironolactone.', 'role': 'assistant'}]