This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Gastrointestinal tract, Subject name: Pharmacology
[{'content': 'Regarding aprepitant all are true except: \nSelect and explain. \nA. Agonist at NK1 receptors, B. Crosses Blood Brain Barrier, C. Ameliorate nausea and vomiting induced by chemotherapy, D. Metabolized by CYP450 enzymes', 'role': 'user'}, {'content': 'Answer: A \nExplanation: it is a recently introduced selective high affinity NK1 receptor antagonst that blocks the emetic action of substance P,with little effect on 5HT3and D2 or other receptor ESSENTIALS OF MEDICAL PHARMACOLOGY SEVENTH EDITION KD TRIPATHI PG NO.669', 'role': 'assistant'}]