This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': 'Mutations in the developmental transcription factors or their downstream target genes are rare causes of thyroid agenesis or dyshormonogenesis. All are examples of thyroid transcription factors, EXCEPT: \nSelect and explain. \nA. Thyroid transcription factor (TTF)-1, B. TTF-2, C. Paired homeobox-8 (PAX-8), D. Sodium iodide sympoer', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Thyroid gland development is coordinated by the expression of several developmental transcription factors. Thyroid transcription factor (TTF)-1 TTF-2 Paired homeobox-8 (PAX-8) are expressed selectively in the thyroid gland. They dictate thyroid cell development and the induction of thyroid-specific genes such as Thyroglobulin (Tg) Thyroid peroxidase (TPO) Sodium iodide sympoer (Na+/I, NIS) Thyroid-stimulating hormone receptor (TSH-R). Sodium iodide sympoer (Na+/I, NIS) is a thyroid specific gene and not a transcription factor. Mutations in these developmental transcription factors or their downstream target genes are rare causes of thyroid agenesis or dyshormonogenesis. Ref: Harrison, E-18, P-2912', 'role': 'assistant'}]