This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Breast, Subject name: Pathology
[{'content': 'AKT1 E17K somatic mutation is associated with \nSelect and explain. \nA. Gastric carcinoma, B. Breast carcinoma, C. Ovarian carcinoma, D. Pancreatic carcinoma', 'role': 'user'}, {'content': 'Answer: B \nExplanation: AKT1 is a member of the serine-threonine kinase class that plays a key role in cellular processes, including growth, proliferation, survival, and angiogenesis. It is a downstream mediator of phosphatidylinositol 3-kinase which, along with AKT1, is a key mediator of proliferation and survival pathways frequently activated in cancer .The single hotspot mutation AKT1 has been described in several cancers, with the highest incidence observed in breast cancer.', 'role': 'assistant'}]