This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anaemia in Pregnancy, Subject name: Gynaecology & Obstetrics
[{'content': 'Use of folic acid to prevent congenital malformation should be best initiated; \nSelect and explain. \nA. During lst trimester of pregnancy, B. During 2nd trimester of pregnancy, C. During 3rd trimester of pregnancy, D. Before conception', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Therapy recommendations suggest that women begin taking folic acid supplements before becoming pregnant and continue taking the supplements of at least 0.4 mg/day throughout the first trimester to reduce the risk of neural tube defects. recommended because it has been shown to reduce the occurrence and recurrence of neural tube defects . For low-risk women, folic acid supplementation of 400 micrograms per day currently is recommended because nutritional sources alone are insufficient. For women at high risk of NTDs or who have had a previous pregnancy with an NTD, folic acid supplementation of 4 mg per day is recommended.', 'role': 'assistant'}]