This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': "All of the following statements about `Aprepitant' are true, except: \nSelect and explain. \nA. Agonist at Neurokinin receptor (NK1), B. Crosses the blood brain barrier, C. Metabolized by CyP3A4 pathway, D. Ameliorates nausea and vomiting of chemotherapy", 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans is 'a' i.e. Agonist at Neurokinin receptor (NK1) Aprepitant is an antiemetic substance that belongs to a class of drugs called substance P antagonists. o The compound mediates its effect by blocking the neurokinim 1 (NK1) receptor. o Aprepitant crosses the blood brain barrier. o Aprepitant is used for chemotherapy induced nausea & vomiting (CINY), and post- operative nausea & vomiting (PONV). o After absorption aprepitant is bound extensively to plasma proteins (>95%); it is metabolized avidly, primarily by hepatic CYP 3A4 and is excreted in the stools.", 'role': 'assistant'}]