This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Urinary tract, Subject name: Pathology
[{'content': 'Alpo&;s syndrome is due to defective- \nSelect and explain. \nA. Collagen, B. Elastin, C. Fibrillin, D. Proteoglycan', 'role': 'user'}, {'content': "Answer: A \nExplanation: Out of various hereditary nephritis, Alpo's syndrome is relatively more common and has been extensively studied. This is an X-linked dominant disorder having a mutation in a-5 chain of type IV collagen located on X-chromosome. Ref: Harsh Mohans textbook of pathology 6th edition page 678", 'role': 'assistant'}]