This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Various factors are involved in inflammation. Which among the following is NOT a mediator of inflammation? \nSelect and explain. \nA. Tumour Necrosis Factor (TNF), B. Interferon, C. Myeloperoxidase, D. Prostaglandins', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Tumour necrosis factor, interferon, prostaglandins are mediators of inflammation. The protein MPO is a marker of azurophil granules. MPO reacts with H2O2, formed by the NADPH oxidase, and increases the toxic potential of this oxidant. Through oxidation of chloride, tyrosine, and nitrite, the H2O2-MPO system induces formation of hypochlorous acid (HOCl), other chlorination products, tyrosine radicals, and reactive nitrogen intermediates, all of which can attack the surface membrane of microorganisms. Ref: Borregaard N., Boxer L.A. (2010). Chapter 66. Disorders of Neutrophil Function. In J.T. Prchal, K. Kaushansky, M.A. Lichtman, T.J. Kipps, U. Seligsohn (Eds), Williams Hematology, 8e.', 'role': 'assistant'}]