This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Physiology
[{'content': 'SHBG is decreased in \nSelect and explain. \nA. Hypehyroidism, B. Increased androgen, C. Increased estrogen, D. Pregnancy', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Sex hormone-binding globulin (SHBG),a plasma b-globulin, produced by the liver, which binds testosterone and, with a weaker affinity, estrogen; serum levels of SHBG in women are twice those found in men; serum concentrations are increased in ceain types of liver disease and in hypehyroidism but are decreased with advancing age, by androgens, and in hypothyroidism.Ref: Ganong&;s review of medical physiology;24th edition; page no:-427', 'role': 'assistant'}]