This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
[{'content': 'Which of the following (in maternal serum) indicate open neural tube defect: March 2011 \nSelect and explain. \nA. Increased folic acid levels, B. Increased Alpha fetoprotein levels, C. Decreased Alpha fetoprotein levels, D. Decreased beta-HCG', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. B: increased Alpha fetoprotein levels MSAFP level is elevated in 1) wrong gestational age, 2) open neural tube defect (NTD's), 3) multiple pregnancies, Rh isoimmunisation 4) IUFD, 5) anterior abdominal wall defects and 6) renal anomalies Risk factors for NTD: Family history of neural tube defects Maternal diabetes insufficient folic acid intake during pregnance Maternal intake of anti-epileptics", 'role': 'assistant'}]