This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': 'Limited cutaneous systemic sclerosis have the following characteristic autoantibody positivity: \nSelect and explain. \nA. Anti Topoisomerase I, B. Anti-RNA polymerase III, C. Scl-70, D. Anticentromere', 'role': 'user'}, {'content': "Answer: D \nExplanation: Subset of systemic sclerosis limited cutaneous scleroderma has the following features: Skin involvement-Indolent onset and progression. Limited to fingers. Raynaud's phenomenon-Precedes skin involvement; associated with critical ischemia Pulmonary aery hypeension-Frequent, late, may be isolated Pulmonary fibrosis - rare scleroderma renal crisis-Very rare Calcinosis cutis-Frequent, prominent Characteristic autoantibodies-Anti Centromere In Diffuse systemic sclerosis Characteristic autoantibodies-Anti Topoisomerase I (Scl-70), anti-RNA polymerase III Ref: Harrison, E-18, P- 2758.", 'role': 'assistant'}]