This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
[{'content': 'Drug resistance in MTB is due to \nSelect and explain. \nA. Conjugation, B. Transformation, C. Transduction, D. Chromosomal mutation', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Mutational drug resistance plays a major role in Mycobacterium tuberculosis.', 'role': 'assistant'}]