This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Medical Illness Complicating Pregnancy, Subject name: Gynaecology & Obstetrics
[{'content': 'Drug of Choice for hypehyroidism in pregnancy: \nSelect and explain. \nA. Methimazole, B. Carbimazole, C. Propylthiouracil, D. I-131', 'role': 'user'}, {'content': 'Answer: C \nExplanation: In a case of thyrotoxicosis during pregnancy, lodine-131 is contraindicated. Propylthiouracil is the drug of choice for thyrotoxicosis in pregnancy. It is highly protein bound and therefore less amount of drug is transferred across placenta and in milk. With carbimazole and methimazole there is risk of fetal hypothyroidism, aplasia cutis, and fetal agranulocytosis.', 'role': 'assistant'}]