This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Gynaecological oncology, Subject name: Gynaecology & Obstetrics
[{'content': 'Which of the following strategy has been recommended to reduce the heredity risk for ovarian cancer in women with BRCA -1 and BRCA-2 mutations : \nSelect and explain. \nA. Use of oral contraceptive pills, B. Screening with transvaginal ultrasound, C. Sreening with CA -125, D. Prophylactic oophorectomy', 'role': 'user'}, {'content': 'Answer: D \nExplanation: - women with strong family history of BRCA 1 and BRCA 2 mutations have high chance of developing ovarian cancer. - they are advised to undergo genetic testing for mutations of these genes. - in such women who are positive for such genes and have completed their family is advised to have prophylactic bilateral salpingo oophorectomy after 35 and before 40. Reference: Textbook of gynaecology Sheila balakrishnan, 2nd edition, pg no:276', 'role': 'assistant'}]