This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Parasitology Pa 1 (Protozoology), Subject name: Microbiology
[{'content': 'Splenic rupture is most common in infection with - \nSelect and explain. \nA. Plasmodium vivax, B. Plasmodium ovale, C. Plasmodium malariae, D. Plasmodium falciparum', 'role': 'user'}, {'content': 'Answer: A \nExplanation: 1. Splenomegaly is one of the most common features of malaria. However, spontaneous splenic rupture, although unusual, represents a severe complication often leading to death. It is mostly seen in acute infection and primary attack, and it is most commonly associated withPlasmodium vivax. 2. In benign malaria, after a few weeks of febrile paroxysm, spleen gets enlarged and become palpable. Splenomegaly is due to massive proliferation of macrophages that engulf parasitized and non-parasitized coated RBCs.', 'role': 'assistant'}]