This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Pathology
[{'content': 'Chromosomal mutation in low grade transitional cell cancer of bladder is? \nSelect and explain. \nA. P53, B. Rb gene, C. FGFR3, D. HRAS', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ans. (c) FGFR3(Ref: Robbins 9th/968)*Noninvasive high-grade urothelial carcinoma is associated with loss of the TP53 and RB tumor suppressor genes while Noninvasive low-grade papillary urothelial carcinoma is associated with gain of function FGFR3 and HRAS mutations.', 'role': 'assistant'}]