This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
[{'content': 'Major contribution to cachexia with advanced cancer- \nSelect and explain. \nA. Clathrin, B. Histamine, C. Nutritional demands of cancer, D. Tumor-necrosis-factor (TNF)', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Cachexia is not caused bu nutritional demands of the tumor. It is suspected that TNF produced by macrophages in response to tumor cells or by the tumor cells them self mediate cachexia. TNF mobilize fat from tissue stores and suppress appetite. ROBBINS', 'role': 'assistant'}]