This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Mendalian Inheritance, Subject name: Biochemistry
[{'content': 'Heritable changes in gene expression not caused by alterations in DNA sequence refers to: \nSelect and explain. \nA. Genetics, B. Epigenetics, C. Mutations, D. Transposons', 'role': 'user'}, {'content': "Answer: B \nExplanation: Epigenetics Means 'above genes'. Study of heritable changes in gene expression that donot involve changes to the underlying DNA sequence. This is a change in phenotype without a change in genotype. Epigenetic silencing (Genomic Imprinting) is one of the ways to turn genes off - contribute to differential expression. Major mechanisms of epigenetics DNA methylation (most common) Histone modifications (post translational)", 'role': 'assistant'}]