This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
[{'content': 'Virulence factors for meningococci ? \nSelect and explain. \nA. Capsule, B. Pili, C. Endotoxin, D. All', 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans. is 'a' i.e., Capsule; 'b' i.e., Pili & 'c' i.e., Endotoxin The capsular polysaccharide - It is a major virulence factors - It has antiphagocytic and antibactericidal propeies. - Based on capsular polysaccharide, meningococci have been divided into serogroups. Outer membrane proteins - Pili - Facilitate adhesions - Porins Por A and Por B - Opc - is involved in cell attachment and is a target for bactericidal antibodies. - IgA1 protease - protects from the action of mucosal IgA. - Systems for acquisition of iron - carrying molecules like transferrin and lactoferrin. Lipooligosaccharide (Endotoxin) - Mediates the induction of inflammatory cytokines. - The morbidity and moality of meningococcal bacteremia and meningitis have been directly correlated with the amount of circulating meningococcal endotoxin.", 'role': 'assistant'}]