This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: FMGE 2018, Subject name: Pathology
[{'content': 'Gluten sensitive enteropathy is strongly associated with:- \nSelect and explain. \nA. Blood group B, B. HLA-DQ3, C. HLA-DR4, D. HLA-DQ2', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Gluten sensitive enteropathy /CELIAC SPRUE have a definitive association with HLA DQ2 / DQ8 Also associated with other immune diseases including type 1 diabetes, thyroiditis & Sjogren syndrome Diagnosis of celiac sprue is done by: Multiple intestinal biopsies - Villous atrophy, crypts hyperplasia along with lymphocytic infiltration Detecting antibodies like anti-TTG antibody ; anti-endomysial antibody Skin biopsy showing destruction to dermal papillae by IgA resulting in Dermatitis herpetiformis Normal villus in the small intestine Atrophy of the villi, lengthening of the crypts, and a heavy chronic inflammatory infiltrate in the lamina propria. Dermatitis herpetiformis showing vesicles with erythema on the extensor surface of the forearm.', 'role': 'assistant'}]