This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'True about COX–2 are all EXCEPT : \nSelect and explain. \nA. It is constitutionally expressed on some cell surfaces, B. Activation of COX–2 leads to ulceroprotective effect on gastric mucosa, C. Induced at the site of inflammation, D. It is utilized in generation of eicosanoids with a ring structure', 'role': 'user'}, {'content': 'Answer: B \nExplanation: COX-2 is constitutively active within kidney, endothelium and brain. Recommended doses of\xa0COX-2 inhibitors cause renal toxicities similar to those associated with other NSAIDs.\nCOX-2 inhibitors have been shown to have less\xa0gastrointestinal side effects because COX-1 is\xa0mainly involved in protection from gastric ulcers.\nConstitutive COX-1 isoform tend to be house\xa0keeping in function while COX-2 is induced during inflammation.\nCOX have role in synthesis of PG’s from arachidonic acid, PGs have 20C fatty acids containing\xa0cyclopentane ring.\nSelective COX-2 inhibitors increase the risk of MI.', 'role': 'assistant'}]