This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.N.S., Subject name: Medicine
[{'content': 'Neurofibrillary tangles and agarophilic plaque are character-istic feature of \nSelect and explain. \nA. Alzheimers d/s, B. CJD, C. Hepatic encephalopathy, D. Parkinsonism', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans a: Ref: Harrison 17th ed pg 2541The area affected in Alzheimer's d/s are hippocampus temporal cortex and nucleus basalis of mayemet Microscopic finding are neurofibrillary tangles and senile neuritic plaques Neuritic plaque contain a central core that contain A? amyloid) proteoglycans, apoE4, alpha 1 antichymotrypsin &other proteinsAccumulation of A-beta amyloid on cerebral arterioles is amyloid angi-opathy.NFT- are silver staining, twisted neurofilaments in neuronal cytoplasm which represent abnormally phosphorylated tau protein", 'role': 'assistant'}]