This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Epilepsy, Subject name: Pharmacology
[{'content': 'If carbamazepine is added to valproate, which side effect of valproate can increase? \nSelect and explain. \nA. Thrombocytopenia, B. Hepatotoxicity, C. Hyperammonemia, D. Pancreatitis', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Valproate is metabolized by cytochrome P450 and produce a metabolite which is hepatotoxic Carbamazepine is enzyme inducer which cause the induction of its metabolism and produce more metabolite, thus causing hepatotoxicity', 'role': 'assistant'}]