This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunomodulatory: DMARDS, Monoclonal Antibodies, Subject name: Pharmacology
[{'content': "Anti-TNF alpha drugs are used for the treatment of all of following diseases except \nSelect and explain. \nA. Systemic lupus erythematosis, B. Seronegative arthritis, C. Psoriatic arthritis, D. Crohn's disease", 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. (A) Systemic lupus erythematosus(Ref: Harrison 17/e p2039; KDT 8/e p943)There is already under-expression of TNF-a in SLE, therefore we cannot use anti-TNF drugs for this condition. It is further strengthened by the fact that anti-TNF alpha drugs like infliximab cause SLE as the adverse effect.Indications for TNF-a inhibitorsRheumatoid arthritisJuvenile arthritisPsoriatic arthritisPsoriasisAnkylosing spondylitisCrohn's disease", 'role': 'assistant'}]