This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Acute Kidney Injury, Subject name: Medicine
[{'content': 'In renal failure, metabolic acidosis is due to? \nSelect and explain. \nA. Decreased Cl-loss, B. Loss of HCO3-, C. Decreased excretion of ammonia, D. Used of diuretics', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Metabolic acidosis can occur because of increased endogenous acid production (lactate and ketoacids) loss of bicarbonate accumulation of endogenous acid (as seen in renal failure) -Ammonia is excreted out linked to H+ as ammonium ion and for every positive charge lost, chloride is lost to maintain electroneutrality. -In case of a renal failure both ammonia and protons are retained leading to high anion gap acidosis as the positive charges in the body are increased.', 'role': 'assistant'}]