This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'Child with proteinuria, generalised edema. With hypoproteinemia & hyperlipidemia-M.C. cause is? \nSelect and explain. \nA. Minimal change nephrotic syndrome, B. IgA nephropathy, C. Mesangial glomerulonephritis, D. FSGN', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Minimal change N.S. Nephrotic syndrome characterised by :? Massive proteinuria = (more than 1 gm/m2/day). Hypoalbuminemia (serum albumin below 2.5 g//dl). Edema Hyperlipidemia often associated. Resultant fall in plasma oncotic pressure leads in edema. Stimulation of Renin - Angiotensin system causes sodium & water retention. More than 90% of childhood N.S. is primary. Most common cause of primary N.S. is minimal change. In electron microscopy, Histopathology show loss of podocyl and loss of negatively charged protein leads to selective proteinuria (albumineria", 'role': 'assistant'}]