This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
[{'content': 'Enzyme inactivation is the main mode of resistance to \nSelect and explain. \nA. Aminoglycosides, B. Quinolone, C. Rifampicin, D. Glycopeptides', 'role': 'user'}, {'content': "Answer: A \nExplanation: Refer KDT 6/e p 720 Resistance to quinolone is due to altered DNA gyrase, to Rifampicin is due to mutation in gene rpo! Reducing it's ability for the target and for glycopeptides like vancomycin due to reduced affintiy6 for target site", 'role': 'assistant'}]