This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
[{'content': 'Most commonly associated mutation in prostratic carcinoma is? \nSelect and explain. \nA. p16\\/INK4a, B. PTEN, C. GPST 1, D. APC', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Harshmohan textbook of pathology 7th edition. prostatic carcinoma- at genetic level following epigenetic phenomenon and acquired somatic mutation have been repoed in development of prostatic carcinoma. 1. Epigenetic phenomenon- hyper methylation of GSTP 1 gene promoter causing loss of function of the gene that detoxifyes carcinogens. .', 'role': 'assistant'}]