This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'The following is true about Nesidioblastosis except? \nSelect and explain. \nA. Presents with hypoglycemic attacks, B. Histopathology shows hyperplasia of islet cells, C. Diazoxide is used for treatment, D. More common in adults than in children', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Nesidioblastosis \n\nIn 1938, Laidlow coined the term nesidioblastosis to describe the neodifferentiation of islets of Langerhans from pancreatic ductal epithelium.\nSevere recurrent hypoglycemia associated with an inappropriate elevation of serum insulin, C-peptide and proinsulin defines this disorder.\nThe disorder later was called persistent hyperinsulinemic hypoglycemia of infancy (PHHI); currently many authors prefer the term congenital hyperinsulinism (CI).\nPHHI is the most common cause of hyperinsulinemic hypoglycemia in neonates.\n\n\nusually affects the infants and children. Adults can also be affected but at a much lower incidence.\n\nHistopathology\n\nMicroscopically, pheochromocytomas are composed of polygonal to spindle-shaped chromaffin cells and their supporting cells, compartmentalized into small nests or "Zellballen," by a rich vascular network.\nThe cytoplasm of the neoplastic cells often has a finely granular appearance, highlighted by a variety of silver stains, because of the presence of granules containing catecholamines. Electron microscopy reveals variable numbers of membrane-bound, electron-dense granules, representing catecholamines and sometimes other peptides. The nuclei of the neoplastic cells are often quite pleomorphic.\n\nPresentation\n\nMost patients with PHHI present shortly after birth with symptoms of hypoglycemia (e.g. hunger, jitteriness, lethargy, apnea, seizures). Older children, in addition to above symptoms, may also show diaphoresis, confusion, or unusual mood or behaviour changes.\nThe symptoms may be exacerbated by fasting and may improve after eating.\n\nTreatment\n\nImmediate treatment of hypoglycemia is essential. Patients may require continuous IV glucose infusion. Glucagon may also be administered.\nOther drugs used are diazoxide, octeride and nifedipine.\nSurgical treatment is indicated if medical therapy does not maintain normoglycemia.', 'role': 'assistant'}]