This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Polycystic Kidney Disease, Subject name: Pathology
[{'content': 'Mutation in PKHD1 gene causing autosomal recessive polycystic kidney disease (ARPKD) maps to which chromosome? \nSelect and explain. \nA. 16, B. 4, C. 6, D. 12', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Mutations of the PKHD1 gene, which maps to chromosome region 6p21-p23. Expressed in adult and fetal kidney, also in liver and pancreas. PKHD1 gene encodes fibrocystin.', 'role': 'assistant'}]