This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cervical Carcinoma, Subject name: Gynaecology & Obstetrics
[{'content': 'A cervical Pap smear repo stating that "koilocytic atypia is present" indicates the:- \nSelect and explain. \nA. Presence of high-grade cervical intraepithelial neoplasia, B. Cytologic effect of herpesvirus type 2, C. Cytologic effect of human papillomavirus, D. Presence of chlamydial infection', 'role': 'user'}, {'content': 'Answer: C \nExplanation: HPV infection of squamous cells Produces wrinkled nuclei surrounded by a clear halo. This is called koilocytosis. Whether it is indicative of a low or a high grade lesion in the cervix requires tissue documentation. This is usually obtained with a colposcopic biopsy.', 'role': 'assistant'}]