This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': 'The gene responsible for Ataxia Telangiectasia is located on: \nSelect and explain. \nA. Chromosome 1, B. Chromosome 5, C. Chromosome 11, D. Chromosome 12', 'role': 'user'}, {'content': 'Answer: C \nExplanation: ATAXIA-TELANGIECTASIA This is a hereditary condition transmitted in the autosomal recessive mode combined immunodeficiency is associated with cerebellar ataxia, telangiectasia, ovarian dysgenesis & chromosomal abnormalities. Genetic features : Gene responsible on chromosome 11 Gene product may play a role in DNA repair ATM gene encodes Atm protein kinase, a member of phosphatidyl inositol 3-kinase family Clinical features :- ataxia & chorioathetoid movements noticed in infancy. Telangiectasia involving the conjuctiva & face appears at 5 or 6 years of age. The disease is progressive, with both neurological defects & immunodeficiency becoming severe with time. Death occurs due to sinopulmonary infection early in life , or malignancy in 2nd or 3rd decade. Ref: Kuby Immunology; 6th edition.', 'role': 'assistant'}]