This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Renal physiology, Subject name: Physiology
[{'content': "Orexins are implicated in all except \nSelect and explain. \nA. Wakefulness, B. Sexual behaviour, C. Appetite, D. Alzheimer's disease", 'role': 'user'}, {'content': 'Answer: B \nExplanation: Orexinergic signaling overexpression alters the sleep-wake cycle and secondarily induces beta-amyloid accumulation and tau-mediated neurodegeneration. Therefore, considering that orexinergic system dysregulation impairs sleep-wake rhythms and may influence AD pathology, it is hypothesized that orexin receptor antagonists are likely potential preventive/therapeutic options in AD patients. Orexin cell-specific lesions do not impair sexual performance and motivation but disrupt conditioned responses associated with sexual reward.', 'role': 'assistant'}]