This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Muscle, Subject name: Physiology
[{'content': 'True statement regarding malignant hypehermia is: \nSelect and explain. \nA. Increased Ca++ transpo T-type calcium channels in T-tubules, B. Increased Ca++ transpo T-type calcium channels in L-tubules, C. Increased Ca++ transpo L-type calcium channels in T-tubules, D. Increased Ca++ transpo L-type calcium channels in L-tubules', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Malignant hypehermia is a genetic disorder; there is a defect in the gene that codes for the protein ryanodine receptor (RyR) in skeletal muscle. Ryanodine receptor is a Ca2+-release channel present in the membrane of L-tubule of skeletal muscle. When it couples with dihydropyridine receptor (DHPR)from T Tubules , there is release of Ca2+ into the sarcoplasm, initiating muscle contraction.So Increased Ca++ transpo L-type calcium channels in T-tubules leads to malignant hypehermia DHPR is an L-type voltage-sensitive Ca2+ channel. Rarely inhalational anaesthetics can cause A malignant hypehermia manifesting as muscle rigidity, sweating and masseteric spasm', 'role': 'assistant'}]