This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'BCRABL gene mutation is seen in?\n(A)CML\n(B)AML\n(C)CLL\n(D)ALL \nSelect and explain. \nA. B, B. C, C. A, D. D', 'role': 'user'}, {'content': "Answer: C \nExplanation: Chronic Myeloid leukemia o Chronic myeloid leukemia is a stem cell disease that is characterized by leucocytosis with granulocyc immaturies, basophilia,\nsplenomegaly and disnct chromosomal abnormality - Philadelphia (Ph') chromosome. It is one of the chronic myeloproliferave disorders.\nPathogenesis of chronic mveloid leukemia o CML is an acquired disease of haemopoiec stem cell and Ph’ chromosome is demonstrable in erythroid,\nmyeloid and megakaryocyc precursors. Philadelphia chromosome BCR-ABL fusion gene Philadelphia chromosome is formed as a result of reciprocal translocaon\nbetween long arm of chromosome 22 and chromosome 9 i.e. + (9:22) ABL proto-oncogene from chromosome 9 is translocated to chromosome 22 where BCR\nis present and results in formaon of BCR-ABL fusion chimeric gene BCR ABL gene is hallmark of CML.", 'role': 'assistant'}]