This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': "All of the following conditions have autosomal dominant inheritance except - \nSelect and explain. \nA. Fabry disease, B. Marfan's syndrome, C. Osteogenesis imperfecta, D. Ehlers Danlos syndrome", 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Fabry's disease Autosomal dominant disorders o Normally a gene pair has two alleles. o When one allele becomes abnormal due to mutation it is called heterozygous state. o When both the alleles become abnormal due to mutation it is called homozygous state. o Autosomal dominant disorders are manifested in heterozygous state, i.e. only if one allel is abnormal the disease will be manifested.", 'role': 'assistant'}]