This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pharmacology
[{'content': 'Clomiphene acts to induce ovulation by wof mechanisms \nSelect and explain. \nA. Diminishing ER-mediated negative feedback at the pituitary, B. Increasing the action of ER a in the ovary, C. Increasing the action of ER a in the hypothalamus, D. Increasing the amount of ER a', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Antiestrogens Clomiphene citrate:- It binds to both ERa and ERb and acts as a pure estrogen antagonist.it induces Gn secretion in women by blocking estrogenic feedback inhibition of pituitary. The amount of LH/FSH released at each secretory pulse is increased. In response, the ovaries enlarge and ovulation occurs if the ovaries are responsive to Gn. Adverse effects:- Polycystic ovaries, multiple pregnancy, hot flushes, gastric upset, veigo, allergic dermatitis. Risk of ovarian tumour may be increased. Ref:- kd tripathi; pg num:-312', 'role': 'assistant'}]