This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Ram Prashad is admitted to Guru Teg Bahadur Hospital with respiratory infection for which antibiotic tobramycin is ordered. The clearance and Vd of tobramycin in him are 160 ml/min and 40 L, respectively. If you wish to give Ram Prashad an intravenous loading dose to achieve the therapeutic plasma concentration of 4 mg/L rapidly, how much should be given? \nSelect and explain. \nA. 0.1 mg, B. 10 mg, C. 115.2 mg, D. 160 mg', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Loading dose = Vd x target plasma cone.\n= 40 L x 4 mg/L\n= 160 mg\nClearance plays no role in the determination of loading dose. It is given to confuse you.', 'role': 'assistant'}]