This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Medicine
[{'content': 'Which channel is defective in "Malignant Hyperpyrexia"? \nSelect and explain. \nA. Sodium, B. Potassium, C. Calcium, D. Magnesium', 'role': 'user'}, {'content': "Answer: C \nExplanation: Malignant hypehermia:Inheritance is autosomal dominanceThe defect is located on the long arm of chromosome 19 involving the Ryanodine receptor of the skeletal muscle sarcoplasmic reticulumThis is associated with L-type calcium channelsThere will be a rapid increase in intracellular calcium level in response to halothane and other inhalational anaesthetics or to succinylcholineFeatures are:Elevated temperature,increased muscle metabolism, muscle rigidity, rhabdomyolysis, acidosis and cardiovascular instability develop within minutesThis rare condition is often fatal (ref: Harrison's 17/e p118, 18/e p144)", 'role': 'assistant'}]