This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Structure & Function of Protein, Subject name: Biochemistry
[{'content': 'In type I collagen, telopeptide corresponds to- \nSelect and explain. \nA. COOH-terminal with super helical conformation NH2- terminal with super helical conformation, B. Both COOH and NH2-terminals are not super helical conformation, C. Both COOH and NH2-terminals super helical conformation, D. Both COOH and NH2-terminals super helical conformation', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ans. D. Both COOH and NH2-terminals superhelical conformationStructure of collagen molecule:-Pro-collagen is comprised of two alpha-1 chains and one alpha-2 chain intertwined into a triple helix. Pro-peptide domains at the carboxy-terminals and amino-terminals are cleaved, resulting in formation of mature collagen. When collagen is degraded, during physiological turnover or pathological adverse remodeling, telopeptide (from the amino- terminals or carboxy-terminals) are cleaved and released into the plasma.Urinary crosslinked N-terminal telopeptide and C terminal telopeptide of type 1 collagen are used as markers of bone resorption in osteoporosis.', 'role': 'assistant'}]