This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'All of the following are positive acute phase reactants except________. \nSelect and explain. \nA. Albumin, B. Serum amyloid (SAA), C. C-reactive protein (CRP), D. Fibrinogen', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Acute-phase proteins are plasma proteins, mostly synthesized in the liver, whose plasma concentrations may increase\xa0several\xa0hundred-fold\xa0as\xa0part\xa0of\xa0the\xa0response to\xa0inflammatory\xa0stimuli.\nThree\xa0of\xa0the\xa0best-known\xa0of these proteins are:\n\nC-reactive protein (CRP).\nFibrinogen.\xa0\nSerum amyloid A (SAA) protein.\xa0\n\nAcute-phase proteins have beneficial effects during acute inflammation, but prolonged production of these proteins (especially SAA) in states of chronic inflammation can, in some cases, cause secondary amyloidosis.\nChronically elevated plasma concentrations of hepcidin reduce the availability of iron and are responsible for the anemia associated with chronic inflammation.\nAlbumin is a negative acute-phase protein, which is decreased in plasma concentration during acute phase response.\nReference-Robbins BASIC PATHOLOGY 10th edition pg-87', 'role': 'assistant'}]