This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Apoptosis activating factor 1 (Apaf-1) \nSelect and explain. \nA. Activates caspase 9, B. Activates caspase 8, C. Activates Bcl-1 and Mcl-1, D. Binds with mitochondrial cytochrome C', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Apaf-1 combines with cytoplasmic cytochrome C that leads to formation of apoptosome complex which further triggers caspase 9 activation. Thus, leading to apoptosis via intrinsic pathway.', 'role': 'assistant'}]