This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Breast, Subject name: Pathology
[{'content': 'The type of mammary ductal carcinoma in situ (DCIS) most likely to result in a palpable abnormality in the breast is \nSelect and explain. \nA. Apocrine DCIS, B. Neuroendocrine DCIS, C. Well differentiated DCIS, D. Comedo DCIS', 'role': 'user'}, {'content': 'Answer: D \nExplanation: DCIS has a wide variety of histologic appearances. Architectural patterns often are mixed and include solid, comedo,n cribriform, papillary, micropapillary, and "clinging" types.The comedo subtype is distinctive and is characterized by cells with high-grade nuclei with extensive central necrosis ref : Robbins Basic Pathology, 9E,page-710 ref img', 'role': 'assistant'}]