This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Translation, Subject name: Biochemistry
[{'content': 'The hydrolytic step leading to the release of a polypeptide chain from a ribosome is catalyzed by which of the following? \nSelect and explain. \nA. Dissociation of ribosomes, B. Peptidyl transferase, C. Release factors, D. Stop codons', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Peptidyl transferase is responsible for the release of peptidyl chain from a ribosome The release is not done by releasing factor, During termination of translation we have releasing factors: In prokaryotes - RF 1 2 3 Eukaryotes - eRF Releasing factor (misnomer) - it can only recognize the stop codon Hence, The hydrolytic step leading to the release of a polypeptide chain from a ribosome is catalyzed by Peptidyl transferase (not by releasing factors).', 'role': 'assistant'}]