This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Blood, Subject name: Pathology
[{'content': "Myd88 L265p mutation is seen in: \nSelect and explain. \nA. Multiple myeloma, B. Waldenstrom's macroglobulinemia, C. ALL, D. Chronic myeloid leukemia", 'role': 'user'}, {'content': "Answer: B \nExplanation: B i.e. Waldenstrom's macroglobulinemiaRef: Robbins 9th edition, page 538Explanation:Waldenstrom MacroglobulinemiaIndolent neoplasm.Also known as lymphoplasmacytic lymphoma.Involves bone marrow (100%), liver, spleen, lymph nodes (15 - 20%).Rare sites of involvement lung and testis (PGIMER exam options).IgM secretion.MYD88 mutation - virtually in all cases.Associated with cold agglutinin AIHA and Hyperviscosity syndrome in 15%.", 'role': 'assistant'}]