This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autacoids, Subject name: Pharmacology
[{'content': 'Which of the following drug, if given with terfenadine can cause ventricular Arrythymia \nSelect and explain. \nA. Ketoconazole, B. Griesofulvin, C. Ampicillin, D. Sparfloxacin', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ketoconazole alters the metabolism of terfenadine in normal men and women. This results in accumulation of the parent drug, and is associated with significant prolongation of QTc. This drug combination should be avoided Refer kDT 6/e p156', 'role': 'assistant'}]