This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Glycogen, Subject name: Biochemistry
[{'content': 'Which of the following condition causes hyperuricemia due to both increased production and decreased excretion? \nSelect and explain. \nA. PRPP Synthetase over activity, B. Glucose-6-phosphatase Deficiency, C. HGP deficiency, D. Renal failure', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Von Gierke disease cause hyperuricemia by both ways: Overproduction: Glucose 6 phosphatase deficiency leads to diversion of glucose-6-phosphate to HMP shunt -| ribose-5-phosphate -|PRPP - nucleotide synthesis - |Uric Acid. Underexcretion: Accumulated lactic acid competes with uric acid for renal excretion.', 'role': 'assistant'}]