This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Nervous system, Subject name: Physiology
[{'content': 'Which of the following statements is true about presynaptic inhibition? \nSelect and explain. \nA. It results due to failure of the action potential to reach the synapse, B. It occurs due to hyperpolarisation of presynaptic membrane, C. It occurs due to inhibition of release of neurotransmitter from presynaptic terminal, D. It occurs due to blockade of neurotransmitter receptors', 'role': 'user'}, {'content': 'Answer: C \nExplanation: presynaptic inhibition into two categories: (1) inhibition mediated by axo-axonic or dendro-axonic projections (i.e., a third pay interferes with the transmission of synaptic responses between a synaptically coupled pair of two neurons), which we may describe as heterosynaptic inhibition; and (2) inhibition mediated by the release of neurotransmitter from the active presynaptic terminal itself, or autoreceptive inhibition Ref: guyton and hall textbook of medical physiology 12 edition page number:546,547,548', 'role': 'assistant'}]