This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': "All of the following are true about Sickle cell disease, Except: \nSelect and explain. \nA. Single nucleotide change results in change of Glutamine to Valine, B. RFLP results from a single base change, C. 'Sticky patch' is generated as a result of replacement of a non polar residue with a polar residue, D. HbS confers resistance against malaria in heterozygotes", 'role': 'user'}, {'content': "Answer: C \nExplanation: C i.e. 'Sticky patch' is generated as a result of replacement of a non polar residue with a polar residueIn sickle cell anemia- Glutamic acid is replaced by valine at sixth position in /3 - globin chainQ.Sticky patch is generated as a result of replacement of polar residue (negatively charged glutamate amino acid) with a nonpolar hydrophobic residue (valine)Q. This change makes HbS (sickle cell hemoglobin) less soluble, when deoxygenated and cause sicklingQ.HbS confers resistance against malaria in heterozygotesQ.", 'role': 'assistant'}]