This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Mendelian Disorders: Single-Gene Defects, Subject name: Pathology
[{'content': 'The inheritance pattern of familial retinoblastomas is - \nSelect and explain. \nA. AD, B. AR, C. X linked dominant, D. X linked recessive', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., AD Examples oflnherited Predisposition to CancerINHERITED C ANCER SYNDROMES (AUTOSOMAL DOMLNANT)GeneInherited PredispositionRBp53pl6;TNK4AAPCNF-LNF-2BRCA-1, BRCA-2MEN-1, RETMSH-2, MLH-1, MSH-6PTCHPTENLKB-1VHLRetinoblastomaLt-Fraumeni syndrome (various tumors)MelanomaFamilial adenomatous polyposis/colon cancerNeurofibromatosis 1 and 2Breast and ovarian tumorsMultiple endocrine neoplasia 1 and 2Hereditary' nonpolyposis colon cancerNevoid basal cell carcinoma syndromeCowden syndrome (epithelial cancers)Peutz-Jegher syndrome (epithelial cancers)Renal cell carcinomasINHERITED AUTOSOMAL RECESSIVE SYNDROMES OF DEFECTIVE DNAREPAERXeroderma pigmentosumAtaxia-tetangiectasiaBloom syndromeFanconi anemiaFAMILIAL CANCERSFamilial clustering of cases, but role of inherited predisposition not clear for each individualBreast cancerOvarian cancerPancreatic cancer", 'role': 'assistant'}]