This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Anaesthesia
[{'content': 'Earliest sign of systemic absorption of local anaesthetic is – \nSelect and explain. \nA. Convulsions, B. Circulatory collapse, C. Circumoral numbness, D. Respiratory arrest', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Manifestations of local anesthetic toxicity (including lidocaine & bupivacaine)\n\nEarly symptoms (Prodrome) Circumoral numbness, dizziness, tongue paresthesia, restlessness, tinnitus, agitation.\nCNS symptoms :- These are biphasic i.e. excitation (convulsions, restlessness, agitation & tinnitus), followed by depression (drowsiness, disorientation, respiratory depression, unconsciousness).\nCardiovascular manifestations :- hypotension, cardiac arrest, coma.', 'role': 'assistant'}]