This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'ANA seen in SLE is directed against? \nSelect and explain. \nA. dsDNA, B. mRNA, C. Nucleolus, D. Ribosomes', 'role': 'user'}, {'content': 'Answer: A \nExplanation: “Antibodies to double-stranded DNA and the Smith (Sm) antigen are virtually diagnostic of SLE" ----------\xa0Robbins\nAntinuclear antibodies in SLE\n1) Generic antinuclear antibodies (ANA)\n□ These are most common (93-100% of patients), thus are most sensitive antibodies for SLE (best\xa0screening test).\n2) Anti-dsDNA and Anti-smith (Sm) antibodies\n□ These are the most specific antibodies for SLE.\n3) Antihistone antibodies\n□ Particularly seen in drug-induced SLE.\n4) Anti-RNP SS-A (Ro), SS-B (La)\n□ These are seen in neonatal lupus with congenital heart block and in subacute cutaneous lupus. These\xa0antibodies are associated with decreased risk of lupus nephritis.\n5) Other less common types of ANAs in SLE\n□ Anti-U1 RNP\n□ Anti-DNA topoisomerase (Scl-70)\n□ Anticentromere\n□ Anti-histidyl t-RNA synthase', 'role': 'assistant'}]