This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Joint and Soft tissue infections, Subject name: Orthopaedics
[{'content': 'A young child diagnosed with chronic osteomyelitis of the tibia. Doctor begun with sensitive antibiotics. Out of the listed parameters, which is best to monitor the response of antibiotic after 6 days? \nSelect and explain. \nA. ESR, B. C-reactive protein (CRP), C. Differential WBC count, D. Total WBC count', 'role': 'user'}, {'content': 'Answer: B \nExplanation: The C-reactive protein (CRP) values are usually elevated within 12-24 hours (reaches its peak) after the onset of symptoms. It returns to normal within 7-8 days after adequate treatment staed, So it is best to monitor the antibiotic response. ESR returns to normal approximately 3 weeks after treatment is begun Both reactants (CRP+ESR) offer more information if simultaneously elevated. WBC count rises and the haemoglobin concentration may be diminished. In extremely young and old age , these tests are less reliable and may show values within the range of normal.', 'role': 'assistant'}]