This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Tumors, Subject name: Pathology
[{'content': 'Cerebellar hemangioblastoma and retinal tumors are seen in: \nSelect and explain. \nA. Von Hippel Lindau syndrome, B. Neurofibromatosis type 1, C. Tuberous sclerosis, D. Neurofibromatosis type 2', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ref: Chapter 28. CNS. page - 1343: Robbins and Cot ran Pathologic Basis of Disease: 8th editionExplanation:The Von Hippel Lindau gene (VHL) is tumor suppressor gene located on Chromosome 3p25-p26 and down-regulates expression of vascular endothelial growth factor; hence its dysregulation is associated with hemangioblastomas and retinal tumors.The neurofibromatosis type 1 (Chr. 17) is associated with:Optic nerve gliomasLisch nodules (pigmented nodules of the iris)Cafe au lait spots (cutaneous hyperpig- mented macules)Neurofibromatosis type 2 (Chr. 22) is associated with:8th nerve schwannomasMultiple meningiomasGliomasEpendymoma of spinal cordTuberous sclerosis complex: It is associated with:Cortical tubersSubependymal nodulesSubependymal giant cell astrocytomasRenal angiomyolipomasRetinal glial hamartomasPulmonary lymphangioleiomyomatosisCardiac rhabdomyomasShagreen patches (cutaneous leathery thickenings)Ash-leaf patches (hypopigmented areas)Subungual fibromas', 'role': 'assistant'}]