This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'Childhood osteopetrosis is characterized by – a) B/L frontal bossingb) Multiple # (fracture)c) Hepatosplenomegalyd) Cataracte) Mental retardation \nSelect and explain. \nA. bc, B. c, C. ac, D. ad', 'role': 'user'}, {'content': "Answer: A \nExplanation: Osteopetrosis \n\nOsteopetrosis is an autosomal recessive heredofamilial disorder in which partly calcified cartilaginous intercellular ground substance is not regularly reabsorbed & replaced by regular osteoid tissue & bone.\nManifested by :\nIncreased bone density masking the distinction between cortex & medulla, bone within bone appearance (Marble's bone).\nBrittle bone & easily fracturability\nFracture healing satisfactory resulting in skeletal deformities.\nMyelophthisic anemia\nHepatosplenomegaly & presence of immature leukocytes & normoblasts in the peripheral blood.\nGrowth retardation,Macrocephaly.\nThickening of cranial foramina & thus causing pressure on optic nerve & optic atrophy.\nDeafness & blindness\nDental problems & osteomyelitis of the mandible.\nLearning disorder but may have normal intelligence despite hearing & visual loss.", 'role': 'assistant'}]