This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
[{'content': 'What happens to lithium levels in blood when used with hydrochlorothiazide? \nSelect and explain. \nA. Blood levels of lithium rise, B. Blood levels of lithium decrease, C. Blood levels of hydrochlorothiazide rise, D. Blood levels of hydrochlorothiazide fall', 'role': 'user'}, {'content': 'Answer: A \nExplanation: (Refer: Katzung’s Basic and Clinical Pharmacology, 10thedition,pg no: 244)\n\nThiazide diuretics act by inhibiting the NaCl channel of DCT resulting in increased solute loss in urine without affecting the negative free water clearance.\nThis loss of solutes especially sodium is compensated by increased reabsorption in the PCT.\nRenal lithium excretion is affected by changes in the sodium balance.\nDrugs causing renal loss of sodium causes increased reabsorption of lithium in PCT.\nEg: ACE inhibitors, AT2 receptor blockers, NSAIDS, Thiazides', 'role': 'assistant'}]