This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Physiology
[{'content': 'HC1 secretion in gastric phase is increase by \nSelect and explain. \nA. Pepsinogen, B. CCK, C. Gastrin, D. Secretin', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Acid in the antrum inhibits gastrin secretion, paly by a direct action on G cells and paly by release of somatostatin, a relatively potent inhibitor of gastrin secretion. Th effect of acid is the basis of a negative feedback loop regulating gastrin secretion. Increased secretion of the hormone increases acid secretion, but the acid then feeds back to inhibit fuher gastrin secretion. REFERENNCE ; GANONGS REVIEW OF MEDICAL PHYSIOLOGY 24TH EDITION', 'role': 'assistant'}]