This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Mycobacterial Diseases (TB, Leprosy and MAC), Subject name: Pharmacology
[{'content': 'A patient of Chronic Renal Failure with GFR <40 ml/min/m2 is now suffering from Pulmonary TB. Which of the following drug does not require a dose reduction ? \nSelect and explain. \nA. Ethambutol, B. Isoniazid, C. Rifampicin, D. Streptomycin', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Mnemonic : BILE EXCRETED ANTI-MICROBIAL AGENTS: CEF - CEFoperazone, CEFtriaxone R - Rifampacin E- Erythromycin N - Nafacillin A - Ampicilllin L - Lincosamides (Clindamycin) DISEASE - Doxycycline Rifampicin: Its metabolised by liver and excreted the bile.Therefore its dose need not be reduced in a patient with Chronic Renal Failure. Ethambutol and Streptomycin are mainly excreted through the kidney,so they require a dosage modification in Renal Failure.', 'role': 'assistant'}]