This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': 'C3-nephritic factor (C3Ne) is associated with membranoproliferative glomerulonephritis. Which of the following statements regarding C3Ne is most appropriate? \nSelect and explain. \nA. It is a native glomerular antigen, B. It is a circulating immune complex, C. It is an IgG, D. Complement C3 convease', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Activation of the alternate pathway of complement system is seen in type-II membranoproliferative glomerulonephritis. C3 Nephritic factor is an autoantibody of IgG class which is produced against alternate C3 convease. C3Ne, like properdin, stabilizes the C3b which is normally degraded by regulatory complement proteins like H and I. Activation of alternate pathway of complement system immune complex deposition in the glomeruli results in membranoproliferative glomerulonephritis Ref: Fervenza F.C., Cattran D.C. (2009). Chapter 26. Membranous Nephropathy. In E.V. Lerma, J.S. Berns, A.R. Nissenson (Eds), CURRENT Diagnosis & Treatment: Nephrology & Hypeension.', 'role': 'assistant'}]