This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of nucleic acids, Subject name: Biochemistry
[{'content': 'An 8 year-old girl in a developing country with significant corneal scarring and multiple cutaneous skin lesions in sun-exposed areas. Neuro-developmental delay had been present since 3 months of age.What is the probable diagnosis which is due to defective nucleotide excision repair? \nSelect and explain. \nA. Werner syndrome (WS), B. Xeroderma pigmentosum (XP), C. Rothmund-Thomson syndrome, D. Bloom syndrome (BS)', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Xeroderma pigmentosum is an example of defective DNA nucleotide excision repair. There is an inability to repair DNA pyrimidine dimers caused by UV exposure. The following image shows an eight-year-old girl with Xeroderma pigmentosum. Frontal image of the face, showing large hyperkeratotic lesions with some induration suspicious of actinic keratosis and early squamous cell carcinoma. Also numerous hyper-pigmented lentigos and xerosis on the entire front of the face. Reference: Harpers illustrated biochemistry 30th edition', 'role': 'assistant'}]