This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Physiology
[{'content': 'Hepatic stage of erythropoiesis is during: \nSelect and explain. \nA. First trimester of pregnancy, B. Second trimester of pregnancy, C. Perinatal period, D. Puberty', 'role': 'user'}, {'content': 'Answer: B \nExplanation: SITE OF ERYTHROPOIESIS\xa0IN FETAL LIFE\n\xa0\nIn fetal life, the erythropoiesis occurs in three stages:\n\xa0\n\nMesoblastic stage\nDuring the first two months of intrauterine life, the RBCs are produced from mesenchyme of yolk sac.\nHepatic stage\nFrom third month of intrauterine life, liver is the main organ that produces RBCs. Spleen and lymphoid organs are also involved in erythropoiesis.\nMyeloid stage\nDuring the last three months of intrauterine life, the RBCs are produced from red bone marrow and liver.\n\nAreas of the Body That Produce Red Blood Cells:\nIn the early weeks of embryonic life, primitive, nucleated RBCs are produced in the yolk sac. During the middle trimester of gestation, the liver is the main organ for production of RBCs, but reasonable numbers are also produced in the spleen and lymph nodes. Then, during the last month or so of gestation and after birth, RBCs are produced exclusively in the bone marrow.\nReference: GUYTON AND HALL TEXTBOOK OF MEDICAL PHYSIOLOGY, THIRTEENTH EDITION(INTERNATIONAL EDITION ) page no 445,446', 'role': 'assistant'}]