This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
[{'content': 'Prions. True statement is: \nSelect and explain. \nA. Defect in protein folding, B. Cleave proteins, C. Scarpie is a human disease, D. Are non infectious', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Defect in protein folding', 'role': 'assistant'}]