This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Medicine
[{'content': 'Earliest abnormality of diabetes nephropathy is- \nSelect and explain. \nA. Hyperfiltration, B. Microalbuminuria, C. Hypeension, D. Proteinuria', 'role': 'user'}, {'content': 'Answer: A \nExplanation: At the onset of diabetes, renal hyperophy and Glomerular hyperfiltration are present . Earliest abnormality is Glomerular hyperfiltration and earliest manifestation is abluminuria. In 40%of patients with diabetes who develop diabetic nephropathy ,the earliest manifestation is an increase in abluminuria detected by sensitive radioimmunoassay. Microalbuminuria appears 5-10 yrs after the onset of diabetes. Ref:Harrison 20 th edition pg no 2145', 'role': 'assistant'}]