This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Urinary tract, Subject name: Pathology
[{'content': 'Focal segmental glomerulosclerosis is characterized by? \nSelect and explain. \nA. IgA +/- IgG, B. IgM and C3, C. Granular IgG and C3, D. Linear IgG and C3', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Focal segmental glomerulosclerosis (FSGS) is characterized by sclerosis of some (but not all) glomeruli that involve only a pa of each affected glomerulus. The affected glomeruli exhibit increased mesangial matrix, obliterated capillary lumina, deposition of hyaline (hyalinosis) and foamy (lipid-laden) macrophages. In affected glomeruli, immunofluorescence microscopy often reveals nonspecific trapping of immunoglobulins, usually IgM, and complement in the areas of hyalinosis. On electron microscopy, the podocytes exhibit effacement of foot processes, as in minimal-change disease. Ref: ROBBINS BASIC PATHOLOGY 10th ed Pg no: 556', 'role': 'assistant'}]