This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
[{'content': 'The following statements are true about DPT vaccine except : \nSelect and explain. \nA. Aluminium salt has an adjuvant effect, B. Whole killed bacteria of Bordetella pertussis has an adjuvant effect, C. Presence of acellular pertusis component increases its immunogenecity, D. Presence of H.influenza type B component increases its immunogenicity', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Lets consider each choice one by one.\nOption ‘a’ : Two types of Diphtheria toxoid are in use now. ... Ananthnarayan 7/e, p 238\n\nFluid toxoid\nAdsorbed toxoid\n\nAdsorbed toxoid is purified toxoid adsorbed into insoluble aluminium compounds usually aluminium phosphate less often the hydroxide. Adsorbed toxoid is much more immunogenic than fluid toxoid.\nOption ‘b’ : Pertussis component in DPT (whole killed bacteria of bordetella pertusis) vaccine enhances the potency of the diptheria toxoid.\nPark 18/e, p 135\nMost serous complication of DPT is neurological which is primarily due to pertusis component. Duration of immunity after whole cell pertusis vaccination is short lived, with little protection remaining after 10-12 years.\nOption ‘c’ : To reduce complications of whole killed bacteria of pertusis in DPT, acellular vaccine developed.\n\nProtection against pertussis by vaccines correlated best with the production of antibody to pertactin, fimbriae and pertussis toxin.\nAll acellular pertussis vaccines currently available contain pertussis toxoid. Acellular vaccine is more immunogenic has less adverse effects. It is given as DTaP.\n\nCMDT ‘06, p 1304\nOption ‘d’ : Quadriple vaccine of DPT with H.influenza B is available in India but conjugate vaccine (eg. HIb vaccine) do not interfere with immunogenicity of simultaneously given other vaccines.', 'role': 'assistant'}]