This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': "A 12 year old boy rapidly develops hypoglycemia after moderate activity. On physical examination, kidney and liver are found to be enlarged. Histopathology of liver shows deposits of glycogen in an excess amount. Blood examination reveals raised ketone bodies, lactic acid and triglycerides. What is the diagnosis? \nSelect and explain. \nA. Von Gierke's disease, B. Pompe's disease, C. McArdle's disease, D. Cori's disease", 'role': 'user'}, {'content': 'Answer: A \nExplanation: Type Ia Glycogen Storage Disease-Von Gierke’s Disease\n\nMost\xa0common\xa0Glycogen\xa0Storage\xa0Disorder\xa0in childhood.\nAutosomal recessive.\n\nThe biochemical hallmarks are:\n\nHypoglycemia\nLactic acidosis\nHyperlipidemia\nHyperuricemia\n\nClinical Presentation\nMost commonly present at 3–4 months of age with:\n\nDoll like facies with fat cheeks\nRelatively thin extremities\nShort stature, protuberant abdomen\nMassive hepatomegaly\nKidneys are also enlarged\nNo splenomegaly\nPlasma may be milky due to associated hypertriglyceridemia\n\nReference- Harper’s illustrated biochemistry. 30th edition page no: 179', 'role': 'assistant'}]