This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Febrile response in CNS is mediated by all except \nSelect and explain. \nA. Bacterial toxin, B. IL-l, C. IL-6, D. Interferon', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Fever is produced in response to substances called pyrogens that act by stimulating prostaglandin synthesis in the vascular and perivascular cells of hypothalamus.\nThey can be classified as:\n\nExogenous pyrogens - Endotoxin of gram ‘-’ bacteria, superantigens (gram ‘+’ bacteria).\nEndogenous pyrogens - IL-1, TNF-alpha, Ciliary neurotropic factor and IFN-alpha.\n\nPGE\xa02 is the most important chemical responsible for elevation of hypothalamic set point in the body.\nSo, NSAIDs reduce fever by inhibiting cyclooxygenase and reducing prostaglandin concentration.', 'role': 'assistant'}]