This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Mechanism of action of paclitaxel is - \nSelect and explain. \nA. Topoisomerase inhibition, B. Increases the polymerization of tubulin, C. Inhibits protein synthesis, D. Alkylation of DNA', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e., Increases the polymerization of tubulin o Paclitaxel and docetaxel function as a mitotic spindle poison through high affinity binding to microtubules with enhancement of tubulin polymerization. o The microtubules are stabilized and their depolymerization is prevented inhibition of mitosis and cell division.", 'role': 'assistant'}]