This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Misc., Subject name: Physiology
[{'content': 'RBC transketolase deficiency is seen in \nSelect and explain. \nA. Thiamine deficiency, B. Folic acid deficiency, C. Anaemia, D. Vitamin B12 deficiency', 'role': 'user'}, {'content': "Answer: A \nExplanation: (A) Thiamine deficiency# TRANSKETOLASE is an enzyme of both the pentose phosphate pathway.> Transketolase activity is decreased in deficiency of thiamine, which in general is due to malnutrition. Two diseases are associated with thiamine deficiency: beriberi and Wernicke-Korsakoff syndrome.> Red blood cell transketolase activity is used in the diagnosis of Wernicke's encephalopathy and other B1-deficiency syndromes if the diagnosis is in doubt.", 'role': 'assistant'}]