This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'First cellular change in hypoxia: \nSelect and explain. \nA. Decreased oxidative phosphorylation in mitochondria, B. Cellular swelling, C. Alteration in cellular membrane permeability, D. Clumping of nuclear chromatin', 'role': 'user'}, {'content': 'Answer: A \nExplanation: None', 'role': 'assistant'}]