This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Which of these are associated with increased risk of colorectal Ca -a)  More intake of animal fatb)  Aspirinc)  Ulcerative colitisd)  Amoebic colitise)  Polyps \nSelect and explain. \nA. acd, B. bde, C. cde, D. ace', 'role': 'user'}, {'content': "Answer: D \nExplanation: Risk factors for Colon cancer\n\nDietay factures - explainaed in previous quetion\nHereditary factors\n\tPolyposis coli\xa0\n\tNonopolyposis herditary colon cancer ( also known as Lynch syndrome)\nInflammatory bowel disease\n\t- Long standing IBD increases the risk\n\t- Risk is more with ulcerative colitis than crohn's disese.\n\t- Risk increases with the duration and extent of colitis.\n\n\t4. Streptococcus bovis bacteremia\n\n\nIndividuals who develop endocarditis or septicemia from this bacteria, have a high incidence of occult colorectal tumors and passibly upper GI cancers also.\n\n\t5.\xa0Other Risk factors\n\t(a) Ureterosiginoidostomy\n\t(b) Cigarette smoking - is linked to the development of colorectal adenomas , particularly after >35 yrs of use.\n(c) Acromegaly\n\t(d) Pelvic irradiation\nAspirin & other NSAIDs use has been foud to have a protective effect (Chemopervention)\nOther substance found to have chemoprentive action are → Oral folic acid supplementation, Oral calcium supplementation, Estrogen replacement therapy.", 'role': 'assistant'}]