This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': "Conjugated hyperbilirubinemia is seen in -a) Rotor's syndb) Dubin Johnson syndc) Gilbert's syndd) Breast milk jaundicee) Crigler Najjar syndrome \nSelect and explain. \nA. ac, B. ab, C. ad, D. bc", 'role': 'user'}, {'content': 'Answer: B \nExplanation: Predominantly Unconjugated Hyperbilirubinemia\nExcess production of bilirubin\xa0\nHemolytic anemias\nResorption of blood from internal hemorrhage (e.g.,alimentary tract bleeding, hematomas)\nIneffective erythropoiesis syndromes (e.g. permicious anemia, thalassemia)\n\nReduced hepatic uptake\nDrug interference with membrane carrier systems\nSome cases of Gilbert syndrome\n\nImpaired bilirubin conjugation\nPhysiologic jaundice of the newborn (decreased UGT1A1 activity,decreased excretion)\nBreast milk jaundice (β-glucurondases in milk)\nGenetic deficiency of UGT1A1 activity (Crigler-Najjar syndrome types I and II)\nGilbert syndrome (mixed etiologies)\nDiffuse hepatocellular disease (e.g. viral or drug-induced hepatitis, cirrhosis)\n\nPredominantly conjugated hyperbilirubinemia\nDeficiency of canalicular membrane transponers (Dubin-Johnson syndrome,Rotor syndrome)\nImpaired bile flow', 'role': 'assistant'}]