This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of nucleic acids, Subject name: Biochemistry
[{'content': 'Hereditary orotic aciduria Type-I is due to deficiency of \nSelect and explain. \nA. Orotate phosphoribosyl transferase, B. Ribonucleotide reductase, C. Dihydroorotase, D. Dihydroorotate dehydrogenase', 'role': 'user'}, {'content': 'Answer: A \nExplanation: The orotic aciduria is a consequence of the inability of severely damaged mitochondria to utilize carbamoyl phosphate, which then becomes available for cytosolic overproduction of orotic acid.Type-I orotic aciduria reflects a deficiency of both orotate phosphoribosyltransferase and orotidylate decarboxylaseThe rarer Type-II orotic aciduria is due to a deficiency only of orotidylate decarboxylaseRef: Harper 27e, page no:354', 'role': 'assistant'}]