This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Which of the following least likely to cause increase in bradykinin production? \nSelect and explain. \nA. Perindopril, B. Benzprindopril, C. Irbesaan, D. All of the above', 'role': 'user'}, {'content': "Answer: C \nExplanation: Ans 'c' i.e. Irbesaan AT-II antagonists (e.g. lrbesaan) do not inhibit ACE (rather they block AT-II receptor). o Therefore, they do not interfere with degradation of bradykinin and substance P (bradykinin and substance P are degraded by ACE). o For the same reason AT-II antagonists do not cause cough & angiodema (caused by ACE inhibitors)", 'role': 'assistant'}]