This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Tolcapone is \nSelect and explain. \nA. Ototoxic, B. Nephrotoxic, C. Hepatotoxic, D. All of the above', 'role': 'user'}, {'content': "Answer: C \nExplanation: Tolcapone is a COMT inhibitor used in Parkinson's disease which acts both peripherally & centrally. But it is hepatotoxic.\nEntacapone is a peripheral COMT inhibitor which is safe in hepatic insufficiency.", 'role': 'assistant'}]