This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pharmacology, Subject name: Pharmacology
[{'content': 'Calculate the loading dose of a drug whose systemic bioavailability will be 20%, Vd-200L and target concentration is 5gm/L \nSelect and explain. \nA. 1g, B. 5g, C. 12.5g, D. 25g', 'role': 'user'}, {'content': 'Answer: B \nExplanation: In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose Loading dose-= 1000/20=5 Ref: KD tripathi 8th ed', 'role': 'assistant'}]