This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
[{'content': 'Digoxin toxicity may result from the concurrent administration of digoxin with all of the following drugs EXCEPT \nSelect and explain. \nA. Quinidine, B. Hydrochlorothiazide, C. Triamterene, D. Furosemide', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Triamterene is a potassium-sparing diuretic that may protect against diuretic-induced digoxin toxicity. Digoxin toxicity may be caused by drugs that increase serum digoxin levels or increase the binding of digoxin to its receptor, the sodium-potassium adenosine tn phosphatase (ATPase). Quinidine decreases digoxin volume of distribution and clearance. Verapamil also decreases the clearance of digoxin. Both drugs may\nthereby increase serum digoxin levels and precipitate digoxin toxicity. Diuretics (e.g., hydrochlorothiazide, furosemide) may cause hypokalemia and hypomagnesemia, both of which may predispose to cardiac arrhythmias. Furthermore, hypokalemia increases di-goxin binding to sodium-potassium ATPase.', 'role': 'assistant'}]