This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'First, change of improves weft noted after iron therapy is initiated – \nSelect and explain. \nA. Decreased irritability, B. Reticulcytosis, C. Increase in serum iron levels, D. Replenishment of iron stores', 'role': 'user'}, {'content': 'Answer: A \nExplanation: "When specific iron therapy is given, patients often show rapid subjective improvement, with the disappearance or marked diminution of fatigue, lassitude, and other nonspecific symptoms (e.g. irritability). This response may occur before any improvement in anemia observed" Wintrobe\'s\n\nThe earliest haematological evidence of response of treatment is an increase in the percentage of reticulocytes and their hemoglobin content.\n\nSo,\n\nOverall earliest indicator of improvement → decreased fatigue, lassitude and other nonspecific symptoms\nEarliest haematological evidence of improvement → Increased reticulocyte count.', 'role': 'assistant'}]