This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
[{'content': 'MC gene involved in endometrial carcinoma \nSelect and explain. \nA. PTEN, B. BRAF, C. KRAS, D. Mismatch repair genes', 'role': 'user'}, {'content': 'Answer: A \nExplanation: PTEN - Phosphatase & tensin homologue Cowden syndrome - AD disorder with tumours of skin appendages & increased incidence of Breast, Endometrium, Prostate & thyroid cancer Acts as TSG by serving as a break in the pro-growth PI3K/AKT pathway (MCly mutated p/w in human ca) By phosphorylating a number of substrates like BAD and MDM2, AKT enhances cell survival.', 'role': 'assistant'}]