This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunomodulators, Subject name: Pharmacology
[{'content': 'A patient is given tacrolimus, which antibiotic should not be given to him? \nSelect and explain. \nA. Gentamicin, B. Ciplatin, C. Rifampicin, D. Vancomycin', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Tacrolimus is a calcineurin inhibitor which is a specific T cell inhibitor is a very potent immunosuppressant drug. It is administered orally and by i.v infusion it is metabolized by CYP3A4 and excreted in bile. Among the given drugs Rifampicin is an enzyme inducer -increases several CYP450 isoenzymes like CYP3A4, CYP2D6, CYP1A2, CYP2C subfamily. Hence it increases the metabolism of several drugs like warfarin, tacrolimus, oral contraceptives, coicosteroids , sulfonylureas, ketakonazole,fluconazole,phenytoin,etc.so rifampicin is avoided. ESSENTIAL of MEDICAL pHARMACOLOGY. SEVENTH EDITION -KD TRIPATHI Page no:768,885', 'role': 'assistant'}]