This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Diabetes, Subject name: Pathology
[{'content': 'A 75-year-old woman with well-controlled diabetes complains of poor eyesight. A grayish-white opacification of lens is found during a comprehensive eye examination. Which of the following metabolic pathways is most likely involved in this lens abnormality? \nSelect and explain. \nA. Aldose reductase pathway, B. Amino acid degradation cycle, C. Citric acid cycle, D. Oxidative phosphorylation', 'role': 'user'}, {'content': 'Answer: A \nExplanation: - Given clinical features suggests the diagnosis of cataract. Aldose reductase pathway has been implicated in pathogenesis of diabetic complications in some tissues, including formation of cataracts. Glucose is conveed to sorbitol (sugar alcohol) by this pathway, which can be cytotoxic. This accumulates in lens resulting in its swelling & cataract formation. Snow flake cataract is associated with diabetes None of other choices have been implicated in pathogenesis of cataracts.', 'role': 'assistant'}]