This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Which of the following is the only hemolytic anaemia caused by acquired intrinsic defect in the cell membrane: \nSelect and explain. \nA. Sickle cell anaemia, B. Thalassemia, C. PNH, D. None of the above', 'role': 'user'}, {'content': 'Answer: C \nExplanation: PNH is the only hemolytic anemia caused by an acquired intrinsic defect in the cell membrane.\xa0\nThe stem cells of the bone marrow acquire mutations in Phosphatidyl inositol glycan A (PIGA) gene.\xa0\nThe triad of hemolysis, pancytopenia and thrombosis is unique to PNH.\xa0\nThrombosis is the leading cause of disease related death in PNH.', 'role': 'assistant'}]