This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pharmacology
[{'content': 'True about pioglitazone are all except: \nSelect and explain. \nA. Metabolized in the liver by CYP3A4, B. Selective agonist for the nuclear peroxisome profilerator activated receptor gamma, C. It causes transcription of gene for carbohydrate and fat metabolism in the absence of insulin, D. It should be avoided in a patient with cardio-vascular disease', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Pioglitazone cause activation of genes regulating fatty acid metabolism and lipogenesis in adipose tissue contributes to the insulin sensitizing action. (REF.Essential of medical pharmacology K D TRIPATHI 6 Edition, Page No - 270)', 'role': 'assistant'}]