This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Which of the following is the characteristic of a highly ionized drug? \nSelect and explain. \nA. High protein binding, B. Can cross placental barrier easily, C. Rapidly absorbed from stomach, D. Excreted mostly by the kidneys', 'role': 'user'}, {'content': 'Answer: D \nExplanation: A highly ionized drug is not reabsorbed by the tubules and is easily excreted by the kidneys because it is lipid insoluble. Ref: Dr J G Buch, (2010) Chapter 3, "Pharmacokinetics", "Clinically oriented pharmacology", Newdelhi, Page 13', 'role': 'assistant'}]