This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'Which of the following regarding sickle cell disease is false? \nSelect and explain. \nA. Single nucleotide change results in change of Glutamine to Valine, B. Sticky patch is generated as a result of replacement of a nonpolar residue with a polar residue, C. HbS provides resistance against malaria, D. Binding of deoxyHbA terminates fiber polymerization', 'role': 'user'}, {'content': 'Answer: B \nExplanation: In HbS, the nonpolar amino acid valine has replaced the polar surface residue Glu6 of the β subunit, generating a hydrophobic “sticky patch” on the surface of the β subunit of both oxyHbS and deoxyHbS.\nRef: Harper’s illustrated biochemistry. 30th edition page no: 56', 'role': 'assistant'}]