This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous (Bio-Chemistry), Subject name: Biochemistry
[{'content': "All of the following are (Jnconjugated Hyperbilirubinemias EXCEPT \nSelect and explain. \nA. Criggler Najjar syndrome Type 1, B. Gilbert's syndrome, C. Dubin Johnson syndrome, D. Criggler Najjar syndrome Type 2", 'role': 'user'}, {'content': 'Answer: C \nExplanation: (C) Dubin Johnson syndrome # Crigler-Najjar syndrome (CNS) is a rare autosomal recessive disorder of bilirubin metabolism. Two distinct forms have been described, as follows: type 1 and type 2.> Type 1 CNS, first described in 1952 by Crigler and Najjar, is associated with neonatal unconjugated hyperbilirubinemia (high levels) and kernicterus.> Type 2 CNS (Arias syndrome), first described in 1962 by Arias, presents with a lower serum bilirubin level and responds to phenobarbital treatment.> CNS is elicited by a lack or deficiency of the enzyme uridine diphosphate glycosyltransferase (UGT).> A markedly elevated unconjugated (indirect) hyperbilirubinemia is observed in inherited disorders such as Gilbert syndrome and CNS. Among the inherited unconjugated hyperbilirubinemias, Gilbert syndrome is believed to affect approximately 3-7% of the adult population.> Dubin Johnson syndrome & Rotor syndromes are inborn errors of metabolism which lead to conjugated hyperbilirubinemia', 'role': 'assistant'}]