This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Genetics And Genetic Disorders, Subject name: Pediatrics
[{'content': 'A 10 year old child presents with fever since 24 hours. History reveals 3 episodes of chest infection and passage of bulky, foul smelling stools. The most probable diagnosis is- \nSelect and explain. \nA. Cystic Fibrosis, B. Maple Syrup urine Disease, C. Bilirubin Congugation Defect, D. Criggler Najar Syndrome', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Cystic fibrosis * Recurrent chest infection in a child with evidence of exocrine pancreatic insufficiency (bulky, foul smelling stool) suggest a diagnosis of cystic fibrosis.* Most patients with CF present in childhood. Approx 18% of patients present within the first 24 hr of life with gastrointestinal obstruction, termed Meconium ileus.* Other systems dysfunctions are not present at birth, they may manifest within the first year or two of life including respiratory tract system.1)Lungs and sinus disease # Sinusitis# Pulmonary hypertension - can cause heart failure # Bronchiactasis# Allergic bronchopulmonary aspergillosis # Nasal polyps# Lower respiratory tract infection # Chronic lung disease 2)GIT, Liver and pancreas # Meconium ileus# Rectal prolapse # Malabsorption# Pancreatitis # Constipation# Intussusception # Meconium peritonitis# Bile duct obstruction and biliary cirrhosis3)Endocrine and growth # Diabetes# Osteoporosis# Poor growth4)Infertility # In men due to absence of vas deference# In women due to thick cervical mucus.", 'role': 'assistant'}]