This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'Gluten-sensitive enteropathy is most strongly associated with – \nSelect and explain. \nA. HLA–DQ2, B. BLA–DR4, C. HLA–DQ3, D. Blood group B', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Almost all individuals with celiac disease share the major histocompatibility complex II HLA-DQ2 or HLA-DQ8.\nGliadin is deamidated by the enzyme transglutaminase and deamidated gliadin peptides bind to DQ2 and DQ8.\nRecognition of these peptides by CD4+ T cells leads to secretion of IFN-γ, which damages the intestinal wall.', 'role': 'assistant'}]