This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Which of the following inhalational agent should not be used in closed circuit? \nSelect and explain. \nA. Desflurane, B. Sevoflurance, C. Both 1 & 2, D. Isoflurane', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Sevoflurane, Trilene & Methoxyflurane are avoided in closed circuit.\nSevoflurane reacts with sodalime to produce compound A which is nephrotoxic.\nTrilene reacts with sodalime and produces phosgene gas and dichloroacetylene which can cause ARDS & seizures respectively.\nMethoxyflurane can react with rubber tubing of closed circuit.', 'role': 'assistant'}]