This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
[{'content': 'During a pelvic examination, a gynecologist discovers an adnexal mass in a 32 year old woman. Resection of the mass demonstrates a malignant ovarian tumor. The tumor suppressor gene strongly associated with this tumor is also associated with cancer of which other organ or tissue? \nSelect and explain. \nA. Breast, B. Colon, C. Pancreas, D. Peripheral nerve', 'role': 'user'}, {'content': 'Answer: A \nExplanation: The tumor suppressor gene most strongly associated with ovarian carcinoma is BRCA-1, which is also associated with breast cancer. This tumor suppressor gene is located on 17q. Associate APC (5q), DCC (18q), and p53 (17p) with colon cancer . Associate DPC (18q) with pancreatic cancer.Associate NF-1 (17q) with neurofibromatosis type I, which is associated with peripheral nerve tumors. Ref: Cunningham F.G., Leveno K.J., Bloom S.L., Hauth J.C., Rouse D.J., Spong C.Y. (2010). Chapter 57. Neoplastic Diseases. In F.G. Cunningham, K.J. Leveno, S.L. Bloom, J.C. Hauth, D.J. Rouse, C.Y. Spong (Eds), Williams Obstetrics, 23e.', 'role': 'assistant'}]