This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Central Nervous system, Subject name: Pharmacology
[{'content': 'Renal excretion of lithium is reduced by \nSelect and explain. \nA. Furosemide, B. Indomethacin, C. Hydrochlorothiazide, D. All of the above', 'role': 'user'}, {'content': 'Answer: D \nExplanation: ANTIMANIC AND MOOD STABILIZING DRUGS (Drugs for bipolar disorder) LITHIUM CARBONATE Drug Interactions :- 1. Diuretics (thiazide, furosemide) by causing Na+ loss promote proximal tubular reabsorption of Na+ as well as Li+ - plasma levels of lithium rise. Potassium sparing diuretics cause milder Li+ retention. 2. Tetracyclines, NSAIDs and ACE inhibitors can also cause lithium retention. 3. Lithium reduces pressor response to NA. 4. Lithium tends to enhance insulin/sulfonylurea induced hypoglycaemia. 5. Succinylcholine and pancuronium have pro duced prolonged paralysis in lithium treated patients. 6. Neuroleptics, including haloperidol, have been frequently used along with lithium without problem. However, sometimes, the combination of haloperidol and lithium produces marked tremor and rigidity. The neuroleptic action appears to be potentiated by lithium. Ref:- kd tripathi; pg num:-449', 'role': 'assistant'}]