This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.N.S, Subject name: Pharmacology
[{'content': 'First line therapy in smoking dependence: \nSelect and explain. \nA. Nicotine replacement gum, B. Rimonabant, C. Naloxone, D. Acute cessation', 'role': 'user'}, {'content': 'Answer: A \nExplanation: (Ref: Katzung, 14th ed. pg. 584)Treatment of smoking dependence:* First line: Nicotine replacement therapy (gum, patch, inhaler).* Bupropion and Varenicicline (Nicotine receptor agonist): Also, first line. Considered more effective.* 2nd line: Clonidine and Nortryptiline* Rimonabant: Cannabinoid receptor inverse agonist. Withdrawn due to increased depression and suicide risk.', 'role': 'assistant'}]