This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Pathology
[{'content': 'In hereditary spherocytosis mutation not seen is? \nSelect and explain. \nA. Ankyrin, B. Spectrin, C. Band-3, D. Na+ Cl-. channel protein', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Hereditary spherocytosis is an inherited disorder caused by intrinsic defects in RBC membrane skeleton that render red cells spheroid less deformable and vulnerable to splenic sequestration and destruction. The pathogenic mutation most commonly affect ankyrin, band 3, spectrin or band 4.2. No Na cl channel protein mutation is seen. Ref:Robbins and Cotran Pathologic basis of disease.South Asia Edition-9 volume 1.page no. 632,633', 'role': 'assistant'}]