This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Link reaction, Subject name: Biochemistry
[{'content': 'Pyruvate utilisation is decreased in: \nSelect and explain. \nA. Pernicious anemia, B. Scurvy, C. Folate trap, D. Beri-beri', 'role': 'user'}, {'content': 'Answer: D \nExplanation: PDH complex requires five coenzymes - Vitamin B1, B2, B3, B5 and Lipoic acid. Vitamin B1 deficiency - Beri-beri Beri- beri - |PDH activity - | pyruvate to acetyl-CoA conversion - low pyruvate utilization Vitamins (B1, B2, B3, B5) - decreased energy production and CNS problems (brain cells depend upon this aerobic reaction)', 'role': 'assistant'}]