This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
[{'content': "Mutation in Marfan's syndrome is? \nSelect and explain. \nA. Collagen I, B. Collagen IV, C. Fibrillin I, D. Fibrillin II", 'role': 'user'}, {'content': "Answer: C \nExplanation: Robbins and Cotran pathologic basis of disease South Asia edition. * Marfan's syndrome results from an inherited defect in an extracellular glycoprotein called fibrillin 1 by loss of structural suppo in microfibril rich connective tissues and excessive activation of TGF- beta signally Ref Robbins 9/e pg252", 'role': 'assistant'}]