This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pediatrics, environment and nutrition, Subject name: Pathology
[{'content': "Tobacco induced squamous cell carcinoma doesn't involve mutation in \nSelect and explain. \nA. P53, B. P16, C. P63, D. NOTCH 1", 'role': 'user'}, {'content': 'Answer: B \nExplanation: Tobacco carcinogens induced cancers involve a mutation in the P53 pathway as well as proteins responsible for squamous differentiation . Conversely HPV associated squamous cell carcinomas overexpress P16.Reference: Robbins; 9th edition; Volume II; Oropharyngeal squamous cell carcinoma molecular biology; Page no: 733', 'role': 'assistant'}]