This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology and breast, Subject name: Surgery
[{'content': 'Increased risk factor for carcinoma breast is \nSelect and explain. \nA. BRCA1 mutation, B. Breast feeding, C. Multiparity, D. Smoking', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Risk factors of breast carcinoma Mutation of tumour suppressor genes BRCA1/BRCA2 is thought to be involved with high-risk of breast carcinoma Diet low with phytoestrogens and high alcohol intake have high-risk of breast cancer. Vitamin C reduces the risk. It is more common in nulliparous woman. Attaining early menarche and late menopause have high-risk of breast malignancy. Early child-bearing and breastfeeding reduces the chances of malignancy. Early 1st child bih reduces the risk; late first child bih after 35 years increases the risk. It is more common in obese individuals Ref; (page no;530 ) 5th edition of SRB&;S manual of Surgery.', 'role': 'assistant'}]