This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pharmacology, Subject name: Pharmacology
[{'content': 'Which of the following agents used in hypeension is a prodrug that is conveed to its active form in the brain? \nSelect and explain. \nA. Doxazosin, B. Methyldopa, C. Clonidine, D. Nitroprusside', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Methyldopa (L-a-methyl-3,4-dihydroxyphenylalanine) is an analog of L-dopa. Methyldopa enters the brain an aromatic amino acid transpoer and is conveed to a-methyldopamine and a-methylnorepinephrine. Antihypeensive action appears to be due to stimulation of central a adrenoceptors by a-methylnorepinephrine or a-methyldopamine.Katzung Pharmacology 12th edition Pg: 175', 'role': 'assistant'}]