This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Ophthalmology
[{'content': 'A one year old child having leukocoria was detected to be having a unilateral, large retinoblastoma filling half the globe. Current therapy would involve – \nSelect and explain. \nA. Enucleation, B. Chemotherapy followed by local dyes, C. Direct Laser ablation using photodynamic cryotherapy, D. Scleral radiotherapy followed by chemotherapy.', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Tumor involving less than half of the globe → Multimodal therapy (Chemoreduction followed by local destruction).\nTumor involving half or more of the globe → Enucleation.', 'role': 'assistant'}]