This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Carbohydrates, Subject name: Biochemistry
[{'content': 'In Citric acid cycle, which enzyme is inhibited by arsenite- \nSelect and explain. \nA. Isocitrate Dehydrogenase, B. a ketoglutarate Dehydrogenase, C. Succinate Dehydrogenase, D. Aconitase', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e., a ketoglutarate Dehydrogenase* Arsenite binds to the sulfhydryl group and hence inhibits the activity of enzymes which have lipoamide in the active site* Hence Arsenite inhibits Pyruvate Dehydrogenase and a ketoglutarate dehydrogenase of citric acid cycle* It is an example for non competitive inhibition* Succinate dehydrogenase is inhibited by malonate* Aconitase is inhibited by fluroacetate. It is an example for suicidal inhibition.", 'role': 'assistant'}]