This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'Tyrosinemics are more susceptible to develop: \nSelect and explain. \nA. Adenocarcinoma colon, B. Melanoma, C. Retinoblastoma, D. Hepatic carcinoma', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ans:D.)Hepatic CarcinomaTyrosinemia type I, hepatocellular carcinoma occurs in children who survive beyond 2 yrs.TYROSINEMIA TYPE IThe disease is due to a deficiency in fumaryl- acetoacetate hydrolase.Accumulation of fumarylacetoacetate and its metabolites, paicularly succinyl- acetone, in the urine.Characteristic cabbage-like odor occurs.Liver failure and renal tubular acidosis result.Treatment includes dietary restriction of phenylalanine and tyrosine, and substrate restriction using nitisinone.', 'role': 'assistant'}]