This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
[{'content': 'Treatment for methotrexate poisoning \nSelect and explain. \nA. Dietary folic acid, B. Niacin, C. Folinic acid, D. Biotin', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Methotrexate poisoning: The toxicity of Mtx cannot be overcome by folic acid, because it will not be conveed to the active coenzyme form(due to inhibition of DHFA reductase by Mtx) Treatment:- Folinic acid (N5 formyl THFA, cirovorum factor) rapidly reverses the effects. Thymidine also counteracts Mtx toxicity. Ref:- kd tripathi; pg num:- 862', 'role': 'assistant'}]