This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Aplastic anemia can progress to -a) AMLb) Myelodysplastic anemiac) Pure red cell aplasiad) Paroxysmal nocturnal hemoglobinuriae) Myelofibrosis \nSelect and explain. \nA. acd, B. bcd, C. abd, D. ab', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Aplastic anemia is a pancytopenia with bone marrow hypocellularity. It can progress to –\n\nParoxysmal Nocturnal hemoglobinuria\nMyelodysplastic anemia\nRarely acute leukemia\n\nPure red cell aplasia is a selective disease of absence of erythrocyte progenitor cells. In contrast to aplastic anemia and MDS, the unaffected lineage (WBC and platelets) appear quantitatively and qualitatively normal.\nMyelofibrosis is a clonal disorder of a multipotent hematopoietic progenitor cell of unknown origin and is characterized by\n\nMarrow fibrosis\nMyeloid metaplasia with extramedullary erythropoiesis\nSplenomegaly', 'role': 'assistant'}]