This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
[{'content': 'BRAF mutation is seen in 60% of cancers of \nSelect and explain. \nA. Malignant melanoma, B. Basal cell carcinoma, C. Squamous cell carcinoma, D. Teratoma', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Point mutation of BRAF seen in 60% of malignant melanoma and 80% of benign nevi.Category of oncogenes:1)Growth factors *Overexpression of HGF - Thyroid cancer2)Growth factor receptors *EGFR -Squamous cell carcinoma of lung and glioblastoma*Her2/neu- Breast cancer *FLT3 - Breast cancer, ovarian cancers, and myeloid leukemia*KIT- GIST3)Proteins involved in signal transduction*KRAS-Colon, lung and pancreatic cancers*HRAS- Bladder cancers, kidney tumors*NRAS - Melanoma*ABL -Chronic myelogenous leukemia*BRAF- Melanoma*Beta-catenin- Hepatoblastoma and Hepatocellular carcinoma4)Nuclear regulatory proteins *C-MYC- Burkitt lymphoma*N-MYC- Neuroblastoma, Small cell carcinoma of the lung*L-MYC - Small cell carcinoma of the lung5)Cell cycle regulators*Cyclin D - Mantle cell lymphoma(Ref: Robbins 8/e p281, 283)', 'role': 'assistant'}]