This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Central Nervous system, Subject name: Pharmacology
[{'content': 'Drug of choice in nocturnal enuresis is: \nSelect and explain. \nA. Imipramine, B. Diazepam, C. Amoxapine, D. Reboxetine', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Answer is option 1, imipramine Baseline studies showed significantly larger and less concentrated nocturnal urine among enuretics compared with controls. We observed a marked antidiuretic effect of imipramine in 6 enuretics with severe nocturnal polyuria. The imipramine induced decrease in urine output was accompanied by reduced osmolal clearance. Approximately a third of the observed decrease in solute excretion was attributed to lower excretion of sodium and potassium. Ref:', 'role': 'assistant'}]