This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Neoplastic Agents, Subject name: Pharmacology
[{'content': 'Nitrosoureas used in the treatment of cancer are- \nSelect and explain. \nA. a) Carmustine, B. 5FU, C. Methotrexate, D. Cisplatin', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Carmustine Nitrosoureaso Nitrosoureas (Lomustine and carmustine) are highly lipid soluble alkylating agents - cross blood - brain barrier - Effective in meningeal leukaemias and brain tumours,o Nitrosoureas are highly lipid soluble and can cross blood brain barrier - used in brain tumors like gliomas.o Because they cross BBB, most common adverse effects are nausea, vomiting and other CNS effects,o Bone marrow depression is peculiarly delayed, taking nearly 6 weeks to develop. - delayed neutropeniao Nitrosoureas can cause visceral fibrosis and renal damage.", 'role': 'assistant'}]