This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Normal cytoplasm-to-nucleus ratio is: \nSelect and explain. \nA. 1:01, B. 1:04, C. 6:01, D. 3:01', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Anaplastic cells often display the following morphologic features:\n\nPleomorphism (i.e., variation in size and shape).\nNuclear abnormalities, consisting of extreme hyperchromatism\xa0(dark-staining),\xa0variation in nuclear size and shape, or unusually prominent single or multiple nucleoli.\xa0Enlargement of nuclei may result\xa0in\xa0an\xa0increased nuclear-to-cytoplasmic ratio that approaches 1:1 instead of the normal 1:4 or 1:6. Nucleoli may attain astounding sizes,\xa0sometimes\xa0approaching\xa0the\xa0diameter\xa0of normal lymphocytes.\nTumor giant cells may be formed.\xa0\nAtypical mitoses,\xa0which may be numerous.\xa0Anarchic multiple spindles may produce tripolar or quadripolar mitotic figures.\xa0\nLoss of polarity.\n\n\u200bReference-Robbins BASIC PATHOLOGY 10th edition pg-193', 'role': 'assistant'}]