This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Skin
[{'content': 'Which of the following is true for acanthosis nigricans: \nSelect and explain. \nA. May be an indication of skin malignancy, B. Hypopigmentation, C. May be associated with Insulin resistant diabetes mellitus, D. Commonly occurs in lean and thin', 'role': 'user'}, {'content': "Answer: C \nExplanation: Ans. C: May be associated with Insulin resistant diabetes mellitus Acanthosis nigricans is associated with obesity and insulin resistance in majority of the patients. In few cases, it may be a reflection of endocrinopathy such as acromegaly, cushing's syndrome polycystic ovarian syndrome. It occurs primarily in flexural areas as velvety hyperpigmentation. It may be a reflection of GIT malignancy.", 'role': 'assistant'}]