This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Medicine
[{'content': 'In hemochromatosis, all of the following are affected except \nSelect and explain. \nA. CNS, B. Bronze diabetes, C. Hyperpigmentation, D. Restrictive cardiomyopathy', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Hemochromatosis is a iron storage disorder with genetic heterogenicity resulting in low production of hormone -HEPCIDIN-resulting in increased iron absorption and deposition in various organs. Major clinical manifestations are-cirrhosis of liver, diabetes mellitus, ahritis ,cardiomyopathy ,hypogonadotropic hypogonadism. Symptoms usually develop between 40 and 60 SERUM ferritin is a good index of iron stores. Treatment-weekly or twice weekly phlebotomy of 500ml is indicated to maintain serum ferritin less than 100mcg/l. In cases like anemia and hypoprotienemia-deferoxamine is given parenterally(s.c) as phlebotomy is not indicated Oral chelating agent-deferasirox is effective in thalassemia and secondary iron overload Acquired iron overload -iron loading anemias(sideroblastic anemia, Thalassemia major, chronic hemolytic anemias) ,chronic liver disease. REF:HARRISON 20TH edition pg no. 2977,table-407-1,pg no. 2981', 'role': 'assistant'}]