This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
[{'content': 'Coagulation defect associated with increased coagulation are seen in \nSelect and explain. \nA. Increased protein C, B. Increased protein S, C. Increased anti thrombin 3, D. Protein C resistance', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ref Harrison 16/e p1491 ,9/e p123 Protein C and protein S are two vitamin K-dependent proteins that act in a complex to proteolytically inacti- vate cofactors Va and VIIIa. Protein C activation by thrombomodulin was described earlier; protein S is a cofactor for protein C activity Resistance to activated protein C due to the factor V R506Q (Leiden) mutation is the most common clotting abnormality in patients with venous thromboembolism', 'role': 'assistant'}]