This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NSAIDs, Gout and Rheumatoid Ahritis, Subject name: Pharmacology
[{'content': 'Extracellular adenosine is increased by which of the following DMARDs? \nSelect and explain. \nA. Leflunomide, B. Sulphasalazine, C. Methotrexate, D. Hydroxychloroquine', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Methotrexate: Methotrexate inhibits an enzyme 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase leading to accumulation of AICAR, which blocks adenosine deaminase. Thus adenosine accumulates and it decreases inflammation by acting on adenosine receptors.', 'role': 'assistant'}]