This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Diagnosis in obstetrics, Subject name: Gynaecology & Obstetrics
[{'content': 'In pregnancy with increased MSAFP which of the following should be done? \nSelect and explain. \nA. Repeat measurement of MSAFP at later date, B. USG, C. Amniocentesis, D. Termination of pregnancy', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Maternal Serum Alpha Fetoprotein (MSAFP) estimation at 16 weeks was used as a screening method for open neural tube defects but today,has been almost completely replaced by ultrasonography. Refer page no 486 of Text book of obstetrics,sheila balakrishnan,2 nd edition.', 'role': 'assistant'}]