This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Polycystic Ovarian Syndrome, Subject name: Gynaecology & Obstetrics
[{'content': 'Which of the following is the first line drug for follicle induction in infeility in PCOS \nSelect and explain. \nA. Clomiphene citrate, B. GnRH agonist, C. Combined oral Pills, D. Letrozole', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Letrozole is the Drug of choice- Induction of ovulation in a case of PCOS; Mode of action- Aromatase Inhibitor Decrease Estrogen production-->Inhibit Negative feedback on FSH --> increases FSH --> increase stimulation of follicles Letrozole preferred over Clomiphene citrate because decreases chances of multifetal pregnancy increased live bih rate OHSS : Rare with it Given for 5 days (D5-D9) Sta with 2.5mg Max dose 7.5mg', 'role': 'assistant'}]