This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pancreas, Subject name: Pharmacology
[{'content': 'DPP-4 inhibitor that can be used in renal failure is: \nSelect and explain. \nA. Linagliptin, B. Sitagliptin, C. Vildagliptin, D. Sexagliptin', 'role': 'user'}, {'content': 'Answer: A \nExplanation: DPP-4 inhibitors: Competitive and selective inhibition of DPP-4 which potentiates the action of GLP- 1 and GIP, boosts postprandial insulin release, decreases glucagon secretion and lowers meal-time as well as fasting blood glucose in type 2 diabetics. Eg.: Sitagliptin, Vildagliptin, Saxagliptin, Alogliptin, Linagliptin. Only Linagliptin is safe in renal failure. MC S/E of Gliptins: Nasopharyngitis.', 'role': 'assistant'}]