This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Medicine
[{'content': 'Infliximab is directed against - \nSelect and explain. \nA. Tumor necrosis factor-a (TNF - a), B. Interleukin-1 (IL-1), C. Interleukin -12 (IL -12), D. Intercellular adhesion molecule (ICAM)', 'role': 'user'}, {'content': "Answer: A \nExplanation: TNF-alfa (alpha) inhibitors (TNF-alpha) are a group of medicines that suppress the body's natural response to tumor necrosis factor (TNF), a protein produced by white blood cells that is involved in early inflammatory events. TNF-alfa inhibitors treat a wide range of inflammatory conditions such as RA , juvenile ahritis, crohn's disease, ulcerative colitis , ankylosing spondolytis, and psoriasis . Ref - Tripati 7th edition , Pubmed.com", 'role': 'assistant'}]