This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'All are involved in non toxic transport of ammonia except: \nSelect and explain. \nA. Glutamine synthetase, B. Glutaminase, C. Alanine cycle, D. SGPT', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Transport of Ammonia\xa0\nFree ammonia is toxic to cells especially to brain. Excess\xa0ammonia generated has to be converted to nontoxic form\xa0then transported to liver to enter into urea cycle.\n\nTransport of Ammonia from most of the tissues\xa0including the brain\nTransport of Ammonia from skeletal muscle\n\nTransport of Ammonia from most of the tissues including the brain.\n\nAs Glutamine with the help of the enzyme\xa0Glutamine Synthetase.\n\nGlutamine Synthetase\n\nAmmonia formed in most tissues including the brain is trapped by Glutamate to form Glutamine\nThis is called first line trapping of ammonia\nATP is required for this reaction.\n\nGlutaminase\n\nIn the liver, glutaminase removes the ammonia from\xa0Glutamine.\nAmmonia enter into urea cycle in the liver.\n\nTransport of Ammonia from skeletal muscle.\n\nFrom Skeletal Muscle as Alanine\nIn skeletal muscle, excess amino groups are generally\xa0transferred to pyruvate to form alanine.\n\nKey Concept:\nGlutamine synthase converts NH3 to nontoxic glutamine. Glutaminase releases NH3 for use in urea synthesis.', 'role': 'assistant'}]