This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology and breast, Subject name: Surgery
[{'content': 'Breast conservation surgery is contraindicated in \nSelect and explain. \nA. Tumor > 4 cm, B. Multicentric tumor, C. Axillary LN involvement, D. All of the above', 'role': 'user'}, {'content': 'Answer: D \nExplanation: .Contraindications * Tumour > 4 cm * Positive axillary nodes > N1 * Tumour margin is not free of tumour after breast conservative surgery needs MRM * Poorly differentiated tumour * Multicentric tumour * Tumour/breast size ratio is more (centeral tumour) * Tumour beneath the nipple * Extensive intraductal carcinoma Ref; (page no;553 ) 5th edition of SRB&;S manual of Surgery', 'role': 'assistant'}]