This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'In sickle cell anaemia, the defect can be explained as having arisen from \nSelect and explain. \nA. A base insertion in DNA, B. A base deletion in DNA, C. A base substitution in DNA, D. None of the above', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Sickle cell anaemia is caused by a point mutation (i.e. a base substition).', 'role': 'assistant'}]