This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cardiovascular system, Subject name: Pathology
[{'content': 'Antinuclear antibody specific for SLE is \nSelect and explain. \nA. Anti ds DNA, B. Anti nuclear antibodies, C. Anti centromere antibody, D. Anti histone Ab', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Systemic lupus erythematosus (SLE) is a multisystem autoimmunedisease of protean manifestations and variableclinical behavior. Clinically, it is an unpredictable, remittingand relapsing disease of acute or insidious onset thatmay involve viually any organ in the body; however, itaffects principally the skin, kidneys, serosal membranes,joints, and hea.Antibodies to doublestranded DNA (dsDNA) and the so-called Smith (Sm) antigen can be detected by ELISA or multiplex flow methods and are specific for SLE.Robbins Basic pathology,9th edition,pg no.127', 'role': 'assistant'}]