This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Physiology
[{'content': 'Hereditary spherocytosis is due to deficiency of:September 2007 \nSelect and explain. \nA. Spectrin, B. Pyruvate kinase, C. Cytokeratin, D. Integrin', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. A: SpectrinHereditary spherocytosis (HS) is due to a deficiency of a protein called ankyrin.Ankyrins are cell membrane proteins (thought to interconnect integral proteins with the spectrin-based membrane skeleton)The ankyrin of red blood cells (erythrocytic ankyrin) is called ankyrin-R/ankyrin-1/ ANK1.', 'role': 'assistant'}]