This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'All of the following factors tend to increase the volume of distribution of a drug EXCEPT: \nSelect and explain. \nA. High plasma protein binding, B. Low ionization at physiological pH values, C. High lipid solubility, D. High tissue binding', 'role': 'user'}, {'content': 'Answer: A \nExplanation: -\xa0Factors affecting drug distribution\n\n\xa0 \xa0Lipid solubility - Higher the solubility, higher the distribution\n\xa0 \xa0Ionization at physiological pH - Higher the ionization, lower the distribution\n\xa0 \xa0Degree of plasma protein binding - More the binding, less the distribution\n\xa0 \xa0Affinity for different tissues - Higher affinity, higher distribution\n\xa0 \xa0Regional blood flow - More the flow, more the distribution\n\xa0 \xa0Fat: lean body mass ratio (changes with age) - Increases with age\xa0\n\xa0 \xa0Disease like CHF, uremia, cirrhosis', 'role': 'assistant'}]