This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'H. influenzae has been isolated from the CSF of a 2 year old boy suffering from meningitis. The strain is beta lactamase producing and resistant to chloramphenicol, The most appropriate antimicrobial is \nSelect and explain. \nA. Trimethoprim -- suiphamethoxazole combination, B. Ciprofloxacin, C. Third generation cephalosporin, D. Vancomycin', 'role': 'user'}, {'content': "Answer: C \nExplanation: HI Inlluenzae type b produces J3 lactamases and therefore are resistant to ampicillin. These 3 lactamase producing strains remain sensitive to the extended spectrum cephalosporins * Ceftriaxone or cefotaxime IV are used as a single agents * Infections caused by ampicillin - resistant strains can be treated with 1. Trimethoprim - sulfamethoxazole 2. Amoxicillin I clavulanic acid 3. Extended spectrum cephalosporins 4. Azithromycin and clarithromycin * F'loraquin lones are highly active against H. influenzae but are not currently recommended for the treatment of children or pregnailt women because of possible effects on aicular cailage", 'role': 'assistant'}]