This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Antenatal Care & Assessment of Fetal Well Being, Subject name: Gynaecology & Obstetrics
[{'content': "Maternal serum Alpha-fetoprotein is raised in all the following conditions EXCEPT: \nSelect and explain. \nA. Spina bifida, B. Multiple pregnancy, C. Omphalocele, D. Down's syndrome", 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans. D. Down's syndromeCauses of Raised MSAFPa. Upper GI obstructionb. Wrong dates (under-estimation)c. Obstructive uropathyd. NTDe. Feto-maternal haemorrhagef. Congenital nephrosisg. CAML (Cystic adenomatoid malformation of the lung)h. Placental/cord tumorsi. Sacrococcygeal teratomaj. Multiple pregnancyk. Maternal liver diseasel. Male fetuses have higher MSAFPm. Abdominal wall defectsn. Afro-Caribbean ethnic backgroundo. Associated with increased risk of IUD/PPROM/IUGR/oligohydramnios/pre-eclampsiap. Smoking", 'role': 'assistant'}]