This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Pharmacology
[{'content': 'Which of the following factors markedly increases the risk of valproate-induced liver toxicity? \nSelect and explain. \nA. Male gender, B. Age younger than 2 year, C. Family history of epilepsy, D. Allergic reactions to phenobarbital', 'role': 'user'}, {'content': 'Answer: B \nExplanation: .', 'role': 'assistant'}]