This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'E cadherin gene deficiency is seen in: \nSelect and explain. \nA. Gastric cancer, B. Intestinal cancer, C. Thyroid cancer, D. Pancreatic cancer', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Cadherin is derived from the “calcium-dependent adherence protein.” It participates in interactions\xa0between cells of the same type. The linkage of cadherins with the cytoskeleton occurs through the catenins.\xa0\nThe cell-to-cell interactions mediated by cadherin and catenins play a major role in regulating cell motility, proliferation, and diﬀerentiation and account for the inhibition of cell proliferation that occurs when cultured normal cells contact each other (“contact inhibition”).\nReduced function of E-cadherin is associated with certain types of breast and gastric cancer.\xa0Mutation and altered expression of the Wnt/β-catenin pathway are implicated in\xa0gastrointestinal and liver cancer development.', 'role': 'assistant'}]