This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Medicine
[{'content': 'Lesch-Nyhan syndrome is due to the deficiency of which enzyme? \nSelect and explain. \nA. Glucose 6- phosphatase, B. Glutathione reductase, C. PRPP glutamyl-amidotransferase, D. Hypoxanthine-guanine phosphoribosyl transferase', 'role': 'user'}, {'content': "Answer: D \nExplanation: (D) Hypoxanthine-guanine phosphoribosyl transferase # LESCH-NYHAN SYNDROMEis a sex-linked metabolic disorder since the structural gene for HGPRT is located on the X-chromosome.> It affects only the males and is characterized by excessive uric acid production (often gouty arthritis), and neurological abnormalities such as mental retardation, aggressive behaviour, learning disability etc.> The patients of this disorder 'nave an irresistible urge to bite their fingers and lips, often causing self-mutilation.", 'role': 'assistant'}]