This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pediatric Ohopedics, Subject name: Orthopaedics
[{'content': 'Mutation seen in Marfan syndrome: \nSelect and explain. \nA. Fibrillin-1 gene, B. FGFR-3 gene, C. COL1A1, D. Fibrillin-2', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Marfan Syndrome: Fibrillin 1 gene defect FGFR3- is seen in achondroplasia COL1A1- osteogenesis imperfecta Fibrillin2- Congenital contractural arachnodactyly (CCA) -phenotypically similar to Marfan syndrome', 'role': 'assistant'}]