This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': "In which of the following carcinomas of breast, loss of E-cadherin plays a vital role in pathogenesis? \nSelect and explain. \nA. Paget's disease, B. Ductal carcinoma, C. Lobular carcinoma, D. Medullary carcinoma", 'role': 'user'}, {'content': 'Answer: C \nExplanation: The main pathogenesis underlying Lobular carcinoma is accquired loss of the tumor suppressive adhesion protein E-cadherin, also called as CDH-1.', 'role': 'assistant'}]