This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Inflammatory bowel disease, Subject name: Surgery
[{'content': "Crohn's disease is associated with: \nSelect and explain. \nA. NOD-2/CARD-15 gene, B. P53 suppressor gene, C. Philadelphia chromosomes, D. BRCA-1 gene", 'role': 'user'}, {'content': "Answer: A \nExplanation: Etiology : Unknown Infectious agents proposed as potential causes: Mycobacterium paratuberculosis and measles virus IBD-1 (chromosome 16q) Relatively specific for Crohn's disease IBD-2 (chromosome 12q) More common in Ulcerative colitis on 16q CARD-15/NOD2 mutation lead to CD", 'role': 'assistant'}]