This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NEET 2018, Subject name: Pathology
[{'content': 'Absence of differentiation is known as:- \nSelect and explain. \nA. Metaplasia, B. Anaplasia, C. Dysplasia, D. Hyperplasia', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Solutions: Hallmark feature of malignant transformation Irreversible High degree of pleomorphism (variability) High nucleocytoplasmic ratio Abnormal mitotic figures Metaplasia: Epithelial metaplasia squamous metaplasia in the lungs of smokers Connective tissue metaplasia - myositis ossificans Dysplasia: Mid way b/w anaplasia and metaplasia,early stages reversible, later stages irreversible Anaplasia: Malignant neoplasms that are composed of poorly differentiated cells are said to be anaplastic. Lack of differentiation, or anaplasia, is considered a hallmark of malignancy. Lack of differentiation, or anaplasia, is often associated with many other morphologic changes. Pleomorphism Abnormal nuclear morphology (N:C ratio that may approach 1 : 1, instead of the normal 1 : 4 or 1 : 6) Mitosis Loss of polarity Growing tumor cells obviously require a blood supply, but often the vascular stroma is insufficient, and as a result in many rapidly growing malignant tumors develop large central areas of ischemic necrosis.', 'role': 'assistant'}]