This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'In Ochronosis there is deficiency of which of the following enzymes? \nSelect and explain. \nA. Phenylalanine decarboxylase, B. Homogentisic acid oxidase, C. Alpha ketoglutarate decarboxylase, D. Glucocerebrosidase', 'role': 'user'}, {'content': 'Answer: B \nExplanation: The defective enzyme in Ochronosis (Alkaptonuria) is homogentisic acid oxidase in tyrosine metabolism. Homogentisate gets oxidised by polyphenol oxidase to benzoquinone acetate which undergoes polymerization to form a pigment ALKAPTON. Alkapton gets deposited in connective tissues, bones and various organs resulting in condition called OCHRONOSIS.', 'role': 'assistant'}]