This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Physiology
[{'content': "In which of the following ways does aldosterone react with renal tubular cells? \nSelect and explain. \nA. Increases transpo of ENaCs from the cytoplasm to the cell membrane, B. Binds to steroid receptor inside the nucleus of renal tubular cells, C. Binds to ENaC's on the cell membrane and increase Na+ transpo, D. Binds to G-protein coupled receptors on the cell surface", 'role': 'user'}, {'content': 'Answer: A \nExplanation: Aldosterone increases transpo of ENaCs (epithelial sodium channels) from the cytoplasm to the cell membrane. This is a rapid effect of aldosterone. Adosterone diffuses into the tubular epithelial cells. In the cytoplasm of these cells, aldosterone combines with a mineralocoicoid receptor (MR) protein. The aldosterone-receptor complex diffuses into the nucleus and induces transcription of DNA to form mRNA. The mRNA diffuses back into the cytoplasm and protein formation occurs in the ribosomes. This occurs slowly. The impoant products formed are: Na+K+ATPase, and membrane transpo proteins like epithelial sodium channel proteins. Ref: Guyton And Hall 13th edition Pgno: 970,971', 'role': 'assistant'}]