This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
[{'content': 'drugs with high plasma protein binding are \nSelect and explain. \nA. sho duration of action, B. less drug interactions, C. lower volumes of distribution, D. all the above', 'role': 'user'}, {'content': 'Answer: C \nExplanation: plasma protein binding causes restriction of drugs in the vascular compament and thus lower volume of distribution', 'role': 'assistant'}]