This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'The sign or symptom most suggestive of metastatic disease is: \nSelect and explain. \nA. Paraesthesia, B. Sudden swelling, C. Root resorption, D. Diffuse radiolucency', 'role': 'user'}, {'content': 'Answer: A \nExplanation: None', 'role': 'assistant'}]