This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrine, Subject name: Pathology
[{'content': "DAX 1 gene Mutation is associated with \nSelect and explain. \nA. Cushing's disease, B. Hashimoto's disease, C. Congenital adrenal hypoplaisa, D. Addison's disease", 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ans. C. Congenital adrenal hypoplasiaExplanationDAX1 mutation is seen in congenital adrenal hypoplasia.DAX1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1) is a nuclear receptor protein encoded by the NROBlgene.DAX1 plays an important role in the normal development of several hormone-producing tissues.The adrenal glands,The pituitary gland andHypothalamusThe testes and ovariesMutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism', 'role': 'assistant'}]