This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
[{'content': 'A patient with sore throat has a positive Paul Bunnel test. The causative organism is : \nSelect and explain. \nA. EBV, B. Herpes virus, C. Adeno virus, D. Cytomegalovirus', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Paul Bunell test is the standard diagnostic procedure of infectious mononucleosis which is caused by EBV.\nPaul Bunell test detects heterophile antibody.\n\nPaul Bunell test\n\nIn this test inactivated serum (56 0 C for 30 minutes) in doubling dilutions is mixed with equal volumes of a 1% suspension of sheep erythrocytes.\nAn agglutination titre of 100 or above is suggestive of infectious mononucleosis.\nFor confirmation, differential absorption of agglutinins with guineapig kidney and ox red cells is necessary\nThe Paul Bunell antibody develops early during the course of infectious mononucleosis, and disappears within two months.\nFalse positive : In patient with lymphoma hepatitis, malaria connective tissue disease\n\nRemember :\n– MC cause of heterophile antibody (+)ve infectious mononucleosis is EBV.\n– MC cause of heterophile antibody (–) ve infectious mononucleosis is CMV.\n– Heterophile (–) ve IM also caused by toxoplasmosis, Listeria, non-infectious stimuli.', 'role': 'assistant'}]