This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'A child born normal, at 1year shows enlarged tongue, coarse facies, prominent forehead, flat face and depressed nasal bridge, with an enlarged spleen and liver, is suffering from: \nSelect and explain. \nA. Hand Schuller Christian disease., B. Fabrys disease., C. Hurler syndrome., D. Hypothyroidism.', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Mucopolysaccharidoses\nMucopolysaccharidoses (MPS) result from abnormal degradation of glycosaminoglycans such as dermatan\xa0sulfate, keratan sulfate, heparan sulfate, and chondroitin sulfate resulting in organ accumulation and eventual\xa0dysfunction.\nThe mode of transmission is autosomal recessive except for MPS II, which is X-linked.\xa0In general, MPS are progressive disorders, characterized by the involvement of multiple organs, including the\nbrain, liver, spleen, heart, and blood vessels; many are associated with coarse facial features, clouding of the\xa0cornea, and mental retardation.', 'role': 'assistant'}]