This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
[{'content': 'Neprilysin inhibitor is: \nSelect and explain. \nA. Carperitide, B. Nesiritide, C. Sacubitril, D. Conivaptan', 'role': 'user'}, {'content': "Answer: C \nExplanation: Ref. KDT. Page. 889\nNeprilysin, also known as membrane metallo-endopeptidase (MME)\n\xa0\nSacubitril\n\nSacubitril's active metabolite, LBQ657 inhibits neprilysin, a neutral endopeptidase that would typically cleave natiuretic peptides, which includes: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and c-type natriuretic peptide (CNP)\nThe half life of sacubitril is 1.1 to 3.6 hours\nThe most common adverse reactions \xa0are hypotension, hyperkalemia, cough\nUsed in combination with valsartan to reduce the risk of cardiovascular events in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction.", 'role': 'assistant'}]