This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Urinary tract, Subject name: Pathology
[{'content': 'Polycystic kidney disease is? \nSelect and explain. \nA. Autosomal dominant, B. Autosomal recessive, C. X-linked, D. Multifactorial', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Description: Feature ADPKD ARPKD 1.Inheritance Autosomal dominant Autosomal recessive 2.Cytogenetic defect Chromosome 16 (85%): ADPKD-1 Chromosome 4 (15%): ADPKD-2 Chromosome 6 3.Mutations PKD 1 gene (85%) PKD 2 gene (15%) 6p21 PKHD1 4.Age at presentation Adults (3rd to 5th decades) Infancy, perinatal 5.G/A Macrocysts Cysts derived from all pas of the nephron(glomeruli, tubules) Micro- and macrocysts radiating from the medulla to OUTER COEX 6.Other manifestations Intracranial aneurysms, cysts of other organs None Ref: HARSH MOHAN TEXTBOOK OF PATHOLOGY 6th ed. pg no: 659', 'role': 'assistant'}]