This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Central Nervous system, Subject name: Pharmacology
[{'content': 'Which of the following opioid should not be used with MAO inhibitors? \nSelect and explain. \nA. Morphine, B. Pentazocine, C. Buprenorphine, D. Pethidine', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ref: KD Tripathi 6/e p440 Most of Pethidine is metabolized by MAO-A and is inactivated. Small amount is conveed to nor-Pethidine, which has CNS stimulant propeies. Therefore if combined with MAO inhibitors, most of Pethidine will form nor-Pethidine and the risk of seizures will increase.', 'role': 'assistant'}]