This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Furosemide should not be administered with NSAIDS because they: \nSelect and explain. \nA. Inhibit prostacyclin synthesis, B. Prevent platelet aggregation, C. Decrease sodium reabsorption, D. Increase the secretion of furosemide in urine', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Indomethacin and other NSAIDs diminish\xa0the action of high ceiling diuretics. Inhibition of\xa0PG synthesis in the kidney, through which\xa0furosemide and related drugs induce intrarenal\xa0haemodynamic changes which secondarily\xa0affect salt output, appears to be the mechanism.\xa0Antihypertensive action of thiazides and furosemide\xa0is also diminished by NSAIDs.', 'role': 'assistant'}]