This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Genetics, Subject name: Pathology
[{'content': 'Mode of inheritance of Leber hereditary optic neuropathy is? \nSelect and explain. \nA. Mitochondrial DNA damage disorder, B. Lipid storage disorder, C. Nucleotide Excision Repair disorder, D. Lysosomal storage disorder', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Mitochondrial DNA damage disorder * Important mitochondrial disorders are Pearson syndrome, Leigh syndrome, MELAS, Keamssayre syndrome (KSS), Leber hereditary optic neuropathy (LHON), Chronic progressive ophthalmoplegia (CPEO), Neurogenic weakness with ataxia and retinitis pigmentosa (NARP), infantile myopathy and lactic acidosis (IMLA), and myoclonic epilepsy with raggedred fibres (MERRF).* The organ mostly affected are CNS (neurological), myocardium, skeletal muscle, kidney and liver, i.e. organs which have large number of mitochondria.", 'role': 'assistant'}]