This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti Microbial, Subject name: Pharmacology
[{'content': 'Which vitamin deficiency occurs in patients taking first line antitubercublar drugs - \nSelect and explain. \nA. Niacin, B. Pyridoxin, C. Ascorbate, D. Thiamine', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e., Pyridoxin o Isoniazid reacts with pyridoxal to form a hydrazone, and thus inhibits gneration of pyridoxal phosphate.o Isoniazid also combines with pyridoxal phosphate to interfere with its coenzyme function. Due to formation of hydrazones, the renal excretion of pyridoxine compounds is increasedo Thus, isoniazid therapy produces a pyridoxine deficiency state.", 'role': 'assistant'}]