This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'Why oxygen transpo by haemoglobin is impaired by decreased glycolytic activity? \nSelect and explain. \nA. Reduced synthesis of haemoglobin, B. Reduced energy production, C. Increased production of 2,3 bisphosphoglycerate, D. Decreased production of 2,3 bisphosphoglycerate', 'role': 'user'}, {'content': 'Answer: D \nExplanation: 2,3 bisphosphoglycerate is an impoant allosteric modifier of haemoglobin oxygen saturation and desaturation. During decreased glycolytic activity decreased production of 2,3 bisphosphoglycerate is responsible for increased oxygen affinity for Hb and decreased dissociation from it leading to impaired oxygen delivery to tissues.', 'role': 'assistant'}]