This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
[{'content': "Which of the following test has highest detection rate for Down's syndrome \nSelect and explain. \nA. Maternal serum AFP, B. Integrated screening, C. Quadruple marker test, D. hcG levels", 'role': 'user'}, {'content': 'Answer: B \nExplanation: Integrated screening combines first and second trimester tests.\nThis includes fetal Nuchal Translucency at 11 - 14 weeks + Quadruple markers at 15 - 20 weeks.', 'role': 'assistant'}]