This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Retina, Subject name: Ophthalmology
[{'content': 'Earliest manifestation of diabetic retinopathy? \nSelect and explain. \nA. Hard exudates, B. Soft exudates, C. Microaneurysm, D. Dot and blot hemorrhages', 'role': 'user'}, {'content': "Answer: C \nExplanation: types of diabetic retinopathy 1. NON- proliferative diabetic retinopathy 2. proliferative diabetic retinopathy. NON- proliferative diabetic retinopathy- 1st sign- Microaneurysm , seen on venular end of capillaries, posterior pole of retinain the Inner nucelear layer (5th Retinal layer ) Proliferative diabetic retinopathy.- Hallmark sign -Neovascularisation , that is fragile ,uncontrolled growth of vessels around discor periphral retina . Hard exudates-specific for diabetic retinopathy -these are the lipid droplets seen in outer plexiform layer (6th layer of retina). Soft exudates-cotton wool exudates , diy yellow in colour , due to stasis of axoplasmic flow in retinal nerve fibre layer (2nd retinal layer ) Dot and blot hemorrhages-Due to rupture of microaneurysm in Oiuter plexiform layer (6th layer of retina A.K. henle's layer) Proliferative diabetic retinopathy", 'role': 'assistant'}]