This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': "True statement regarding Hirschsprung's disease? \nSelect and explain. \nA. Giant ganglia are present, B. Mucosa is involved and show foldings, C. Manometry excludes the disease, D. Rectal biopsy is contraindicated in infants", 'role': 'user'}, {'content': "Answer: C \nExplanation: Ans. is 'c' i.e., Manometry excludes the diagnosis o Anorectal manometry is a useful screening procedure for the diagnosis of Hirschsprung's disease. A normal response in course of manometric evaluation precludes diagnosis of Hirschsprung's disease. o However the confirmation of diagnosis in case of Hirschsprung's disease is done by rectal biopsy.", 'role': 'assistant'}]