This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Orthopaedics
[{'content': 'Which is true regarding rheumatoid arthritis - \nSelect and explain. \nA. Small and large joints are affected mostly, B. Younger females are affected more commonly, C. Diagnosed only if Rheumatoid factor is positive, D. Life expectancy is unchanged', 'role': 'user'}, {'content': "Answer: A \nExplanation: Small joints of hand & feet and large joints like elbow, knee and ankle are involved.\nWomen are affected 3 times more commonly than men. Older women (> 60 years) are 6 times more commonly involved than younger one.\nA positive RA factor in the absence of other features is not sufficient evidence for RA.\nLife expectancy is shortened 3-7 years.\nHepatosplenomegaly is not seen except in Felty's syndrome, where RA is associated with splenomegaly.", 'role': 'assistant'}]