This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Increase in MCHC is associated with \nSelect and explain. \nA. Iron deficiency anemia, B. Megaloblastic anemia, C. Anemia of chronic disease, D. Hereditary spherocystosis', 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans is 'd' i.e. Hereditary spherocystosis Mean cell hemoglobin concentration (MCHC) is the average concentration of hemoglobin in a given volume of packed red blood cells, expressed in grams per deciliter. Normal value is 33-37 gm/dlMCHC is increased in hereditary spherocytosis, not because of increased hemoglobin, but due to decerase volume of spherocytes.MCHC is decreased in microcytic hypochromic anemia(iron deficiency anemia & anemia of chronic disease).MCHC remains normal in megaloblastic anemia.", 'role': 'assistant'}]