This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General Microbiology Pa-2 and Pa-3 (Sterilization and Bacterial Genetics), Subject name: Microbiology
[{'content': 'Drug resistant in tuberculosis is due to ? \nSelect and explain. \nA. Transformation, B. Transduction, C. Conjugation, D. Mutation', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Drug resistance in M.tb is by Mutation in Chromosomes Metabolic defects occur as a result of mutation Eg - M.tb is normally catalase +ve INH resistant M.tb are Catalase -ve', 'role': 'assistant'}]