This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Calcium dependant cell adhesion molecule is \nSelect and explain. \nA. Cadherin, B. ICAM-1, C. L-selectin, D. Integrin', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Answer- A. CadherinThe cadherins are calcium-ilependent adhesion molecules. The three most common cadherins are neural (N)-cadherin, placental (P) cadherin, and epithelial (E)-cadherin. All three belong to the classical cadherin subfamily. There are also desmosomal cadherins and proto-cadherins. Cadherins are intimately involved in embryonic development and tissue organization. They exhibit homophilic adhesion. The extracellular domain consists of several cadherin repeats, each is capable of binding a calcium ion. When calcium is bound, the extracellular domain has a rigid, rod-like structure.Following the transmembrane domain, the intracellular domain is highly conserved. The intracellular domain is capable of binding the alpha, beta, gamma catenins.', 'role': 'assistant'}]