This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
[{'content': 'A drug that binds to receptor at a site distinct from the active site and alters the affinity of the receptor for the endogenous ligand is a: \nSelect and explain. \nA. Competitive antagonist, B. Inverse agonist, C. Partial agonist, D. Allosteric modulator', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ref. KDT. Page. 59\nCompetitive (equilibrium type –Allosteric modulator)\n\nThe drug being structurally similar competes with the normal substrate for the catalytic binding site of the enzyme\nThey increase the kM but the Vmax remains unchanged\n\nExamples:\n\nPhysostigmine and neostigmine compete with acetylcholine for cholinesterase.\nSulfonamides compete with P ABA for bacterial folate synthetase. \u2028\nMoclobemide competes with catecholamines for monoamine oxidase-A (MAO-A). \u2028\nCaptopril competes with angiotensin 1 for angiotensin converting enzyme (ACE).', 'role': 'assistant'}]