This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
[{'content': 'Drawback of aesunate is: \nSelect and explain. \nA. Poor bioavailability, B. Rapid recrudescence of malaria, C. Hypoglycemia, D. Hemolysis', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Because aemisinins are sho acting drugs, monotherapy needs to be extended beyond the disappearance of the parasites to prevent recrudescence. After 5 days treatment recrudescence rate is -10%, while with a 3 day course it is -50%. Recrudescence can be totally prevented by combining 3 day aesunate/aemether with a long acting drug ESSENTIALS OF MEDICAL PHARMACOLOGY page no. 830', 'role': 'assistant'}]