This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Li-Fraumeni syndrome has the risk of development of: \nSelect and explain. \nA. Squamous cell carcinoma, B. Basal cell carcinoma, C. Osteosarcoma, D. Both 1 & 3', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Li-Fraumeni syndrome (germline TP53 mutation) is a predisposing factor for osteosarcoma development.\nReference: Shafer’s Textbook of ORAL PATHOLOGY Eighth Edition page no 227', 'role': 'assistant'}]