This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Disorders of Pituitary Gland, Subject name: Pediatrics
[{'content': 'Gigantism is due to: \nSelect and explain. \nA. Increased secretion of coisol, B. Decreased secretion of coisol, C. Increased secretion of growth hormone, D. Decreased secretion of growth hormone', 'role': 'user'}, {'content': 'Answer: C \nExplanation: - Excess GH results in: overgrowth / gigantism during childhood with open epiphysis * After fusion of epiphysis - ACROMEGALY - Features of Acromegaly: Coarse facies large tongue Prognathism(protruded lower jaw) thick skin broad nose headache & visual field defects - Best screening test - IGF 1 levels - TREATMENT: Somatostatin analogues (Octreotide) GH Receptor antagonist (Pegvisomant)', 'role': 'assistant'}]