This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NEET Jan 2020, Subject name: Pharmacology
[{'content': 'Which of the following drugs act by inhibiting DNA replication? \nSelect and explain. \nA. 6 Mercaptopurine, B. Actinomycin D, C. Mitomycin C, D. Asparaginase', 'role': 'user'}, {'content': 'Answer: A \nExplanation: 6 Mercaptopurineis purine antimetabolite therefore it preventsDNAreplication. Mitomycin C is an antitumor antibiotic that inhibits DNA synthesis by producing DNA cross-links which halt cell replication and eventually cause cell death. Actinomycin D acts by inhibiting DNA dependent RNA synthesis. Asparaginase is an enzyme that catalyzes the hydrolysis of l-asparagine to l-aspaic acid and ammonia. They inhibit protein synthesis in tumor cells by depriving them of the amino acid asparagine.', 'role': 'assistant'}]