This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Medicine
[{'content': 'Which of the following most significantly increases the risk of Hepatocellular carcinoma ? \nSelect and explain. \nA. HBV, B. CMV, C. EBV, D. HAV', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Both case-control and coho studies have shown a strong association between chronic hepatitis B carrier rates and increased incidence of HCC.Ref: Harrison; 19th edition; Page no: 544', 'role': 'assistant'}]