This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Pemphigus is characterized by: \nSelect and explain. \nA. Acanthosis, B. Acantholysis, C. Hyperorthokeratosis, D. Hyperparakeratosis', 'role': 'user'}, {'content': 'Answer: B \nExplanation: In pemphigus there is formation of vesicle or bulla intraepithelially, just above the basal layer producing the distinctive suprabasilar split. The intercellular bridges\xa0in supra basal. layers disappear due to edema resulting in acantholysis. Because of this, clumps of degenerating epithelial cells are found in the vesicular space, which are known as Tzanck cells.', 'role': 'assistant'}]