This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Which of the following anticancer drugs can cause a hypercoagulable state \nSelect and explain. \nA. 5–FU, B. L–asparginase, C. Melphalan, D. Carmustine', 'role': 'user'}, {'content': 'Answer: B \nExplanation: L-asparginase causes the breakdown of aspargine and thus interferes with protein synthesis. It can inhibit the pro\xadduction of clotting factors (responsible for cerebral hemorrhage) as well as anti-clotting proteins (can lead to cortical vein thrombosis and other hypercoagulable states).', 'role': 'assistant'}]