This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hepatitis, Subject name: Medicine
[{'content': 'Which of the following viral markers signifies the ongoing viral replication in the case of Hepatitis-B infection? \nSelect and explain. \nA. Anti-HBs, B. Anti-HBc, C. HBe Ag, D. HBs Ag', 'role': 'user'}, {'content': 'Answer: C \nExplanation: HBeAg appearance- high levels of virus replication and reflects the presence of circulating intact virions and detectable HBV DNA. Patients with precore mutations cannot synthesize HBeAg In self-limited HBV infections, HBeAg becomes undetectable sholy after peak elevations in aminotransferase activity, before the disappearance of HBsAg, and anti-HBe then becomes detectable, coinciding with a period of relatively lower infectivity.', 'role': 'assistant'}]