This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': 'Specific antibody associated with primary biliary cirrhosis is: \nSelect and explain. \nA. Anti-myosin, B. Anti-nuclear, C. Anti-mitochondrial, D. Anti-endomysial', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ans. C: Anti-mitochondrial Primary biliary cirrhosis is strongly associated with the presence of anti-mitochondrial antibodies (AMA), which are diagnostic PBC: Associated with CREST syndrome, sicca syndrome, auto-immune thyroiditis, type I DM and IgA deficiency IgG AMA is detected in more than 90% of patients with PBC 90% of women are between 35 - 60 years Earliest symptom is pruritis Eventually hepatocellular failure and poal hypeension develops Lab findings: - Increased serum alkaline phosphatase - Increased serum 5-nucleotidase activity - Increased gamma-glutamyl transpeptidase - Serum bilirubin is usually normal - Aminotransferase levels minimally increased - Treatment: Ursodiol', 'role': 'assistant'}]