This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Blood, Subject name: Pediatrics
[{'content': 'All the following are seen in thalassemia major except: \nSelect and explain. \nA. Microcytic hypochromic anaemia, B. Hepatosplenomegaly, C. Low iron content in blood, D. None', 'role': 'user'}, {'content': "Answer: C \nExplanation: Ans: c (Low iron content in blood)Serum iron content is increased in thalassaemia major and not decreased.THALASSAEMIA MAJOR / COOLY'S ANAEMIAAge is usually 3-6 monthsRegular, monthly blood transfusion dependentClinical Features* Mainly due to extramedullary erythropoiesis in facial and skull bones -> haemolytic facies* HepatosplenomegalyLab Findings* Peripheral smear- hypochromic microcytic anaemia with bizarre fragmented poikilocytes* Intra erythrocytic inclusions - Heinz bodies Heinz bodies are precipitated extra alpha chain* Hb F increased* TIBC normal* Osmotic fragility is reduced* X ray skull - hair on end appearance.Complications 1) Hypersplenism 2) Haemosiderosis 3) Endocrine complications4) Cardiomyopathy - cause of death# Diabetes mellitus# Hypothyroidism# Delayed puberty5) Hyperpigmentation due to melanin deposition6) Growth retardationTreatmentRegular packed cell transfusionBone marrow transfusion is curative", 'role': 'assistant'}]