This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immune system, Subject name: Medicine
[{'content': 'A 14 year old girl on exposure to cold has pallor of extermities followed by pain and cyanosis. In later ages of life she is prone to develop ? \nSelect and explain. \nA. Systemic lupus erythematosis, B. Scleroderma, C. Rheumatoid ahritis, D. Histiocytosis', 'role': 'user'}, {'content': "Answer: B \nExplanation: The probable condition in this case is systemic sclerosis or scleroderma . Raynaud's phenomenon is a universal feature and can precede other features by many years in systemic sclerosis . Involvement of small blood vessels in the extremities may cause critical tissue ischaemia, leading to localised distal skin infarction and necrosis. Ref - Davidsons 23e p1037", 'role': 'assistant'}]