This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cardiovascular system, Subject name: Pathology
[{'content': "In Wegener's granulomatosis cytoplasmic anti neutrophilic antibodies are directed against \nSelect and explain. \nA. Proteinase 1, B. Proteinase 2, C. Proteinase 3, D. Proteinase 4", 'role': 'user'}, {'content': 'Answer: C \nExplanation: Wegener granulomatosis is a necrotizing vasculitis characterized by a specific triad of findings: * Granulomas of the lung and/or the upper respiratory tract (ear, nose, sinuses, throat) * Vasculitis of small to medium-sized vessels (capillaries, venules, aerioles, and aeries), most prominently in the lungs and upper respiratory tract * Glomerulonephritis PR3-ANCAs are present in almost 95% of cases and probably drive the subsequent tissue injury; they also are useful markers of disease activity. (Robbins basic pathology,9th edition.pg no.353)', 'role': 'assistant'}]