This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'To rule out rheumatoid arthritis, most important among the followings is? \nSelect and explain. \nA. HLA DR8, B. HLA DQ1, C. HLA B27, D. HLA DR4', 'role': 'user'}, {'content': 'Answer: D \nExplanation: DR4 is strongly associated with RA(also with Type 1 DM Pemphigus vulgaris).\n\nOther options\n\nHLA-B27 is associated with seronegative spondyloarthropathies (ankylosing spondylitis, Psoriatic arthritis, Reiter’s syndrome, reactive arthritis) and acute anterior uveitis\nHLA DR8 is associated with Type 1 DM.\nHLA DQ1 is associated with pemphigus vulgaris.', 'role': 'assistant'}]