This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Not seen in SLE affected kidney? \nSelect and explain. \nA. Lipoid nephrosis, B. Focal Glomerulonephritis, C. Diffuse Glomerulonephritis, D. Membranous Glomerulonephritis', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Renal manifestations in SLE (Lupus nephritis)\n\n\xa0Nephritis is the most serious manifestation of SLE and renal failure is the most common cause of death in\xa0SLE.\nFindings of SLE nephropathy are called as full house phenomenon.\n\nA. Glomerular diseases\n\nWHO classification lupus nephritis is as follows\n\n1) Class I (minimal or no detectable abnormalities)\n\nIt has the best prognosis.\n\n2) Class II (Mesangial lupus GN or mesangial proliferative)\n\nCharacterized by mesangial cell proliferation and lack of involvement of glomerular capillary wall. Glomerular mesangial deposits of immunoglobulin and complement are the earliest feature and are found in\xa0all types of lupus nephritis.\n\n3) Class III (focal proliferative GN)\n\nThere are subendothelial deposits. Granular deposits also occur in mesangium as occur in all forms of\xa0lupus nephritis.\n\n4) Class IV (Diffuse proliferative GN)\n\nIt is the most common type of lupus nephritis with the worst prognosis. It is characterized by wire loop\xa0lesions. There are subendothelial deposits with granular deposits in the mesangium.\n\n5) Class V (Membranous GN)\n\nThere is widespread thickening of the capillary wall with subepithelial deposits and granular deposits in\xa0the mesangium.\n\n6) Class VI (Sclerosing nephritis)\n\nThere is global necrosis of nearly all glomerular capillaries.\nWire loop lesions are seen most commonly in diffuse proliferative (class IV), but may also be seen in\xa0class III (focal proliferative) and class V (membranous) GN.\n\nB. Tubulointerstitial disease\n\nThough glomeruli are involved primarily in lupus nephritis, interstitium and tubules can also be\xa0involved especially in association with diffuse proliferative glomerulonephritis. Granular deposition of immunoglobulin and complement in tubular basement membrane are seen.', 'role': 'assistant'}]