This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
[{'content': 'Regarding PCOS and hyperinsulinaemia \nSelect and explain. \nA. Hyperinsulinaemia is observed in about 40% to 80% of women with PCOS, B. Metformin has many other health benefits, C. Metformin causes hypoglycaemia in normoglycaemic women, D. Hyperinsulinaemia stimulates hepatic synthesis of SHBG', 'role': 'user'}, {'content': 'Answer: B \nExplanation: In PCOS\n\nHyperinsulinemia is seen in 50-70% cases of PCOS\nInsulin induces LH to cause thecal hyperplasia and secrete androgens\nHyperandrogenism lowers the level of hepatic sex hormone binding globulin\nMetformin treats the root causes, rectifies endocrine and metabolic function, improves fertility rate, used as insulin sensitiser\nIt reduces insulin level, delays glucose absorption, liver production of glucose and improves peripheral resistance\nMetformin do not cause hypoglycemia in a normoglycemic women', 'role': 'assistant'}]