This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Skin
[{'content': 'Acantholysis is due to destruction of \nSelect and explain. \nA. Epidermis, B. Subepidermis, C. Basement memberane, D. Intercelluar substance', 'role': 'user'}, {'content': 'Answer: A \nExplanation: A. i.e. Epidermis', 'role': 'assistant'}]