This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Female Reproductive System, Subject name: Physiology
[{'content': 'Pubey does NOT occur before the age of 8 years because: \nSelect and explain. \nA. The hypothalamus does not secrete GnRH in a pulsatile manner, B. Inadequate synthesis of gonadotropins by the pituitary, C. Gonads are unresponsive to gonadotropin, D. Positive feedback action of gonadal steroids on pituitary', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Pubey and regulation of its onset During childhood the hypothalamus does not secrete significant amount of GnRH because during childhood, the slightest secretion of any sex steroid hormones exes a strong inhibitory effect on hypothalamic secretion of GnRH. But at the time of pubey, the secretion of hypothalamic GnRH breaks through the childhood inhibition and adult sexual life begins.', 'role': 'assistant'}]