This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'The most important adverse effect of i.v. administration of large dose of an amide anaesthetic is : \nSelect and explain. \nA. Bronchoconstriction, B. Hepatic damage, C. Renal failure, D. Seizures', 'role': 'user'}, {'content': 'Answer: D \nExplanation: None', 'role': 'assistant'}]