This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Central Nervous system, Subject name: Pharmacology
[{'content': 'Gender specific adverse effect of valproate is \nSelect and explain. \nA. Weight gain, B. Tremors, C. Alopecia, D. Polycystic ovarian disease', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Long term use of valproate in young girl is associated with higher incidence of polycystic ovarian disease and menstrual irregularities. REf KD Tripathi 8th ed.', 'role': 'assistant'}]