This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'In familial mediterranean fever, the gene encoding the following protein undergoes mutation- \nSelect and explain. \nA. Pyrin, B. Perforin, C. Atrial natriuretic factor, D. Immunoglobulin light chain', 'role': 'user'}, {'content': 'Answer: A \nExplanation: The gene for familial Mediterranean fever has been cloned and its product is called pyrin, (for its relation to fever)\nFamilial Mediterranean fever \n\nThis is a febrile disorder characterized by :\n\n(i)\xa0Attacks of fever\n(ii)\xa0Inflammation of serosal surfaces including peritoneum, pleura and synovial membrane.\n\nThis is the most common cause of a familial form of amyloidosis.\nAmyloid fibril protein is made up of AA protein.\nThe gene for familial Mediterranean fever has been cloned and its product is called pyrin.\nPyrin is responsible for regulation of acute inflammation by inhibiting the function of neutrophils', 'role': 'assistant'}]