This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'a 1 antitripsin deficiency is characterised by deposition of cytoplasmic inclusions which are: \nSelect and explain. \nA. Eosinophillic, B. PAS positive, C. Diastase resistant, D. All of the above', 'role': 'user'}, {'content': 'Answer: D \nExplanation: a1-Antitrypsin deficiency is characterized by the presence of round-to-oval cytoplasmic globular inclusions in hepatocytes, which in routine H&E stains are acidophilic and indistinctly demarcated from the surrounding cytoplasm. They are strongly periodic acid-Schiff (PAS)-positive and diastase-resistant Ref: Robbins 8th edition Chapter 18.', 'role': 'assistant'}]