This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Vitamins and Minerals, Subject name: Biochemistry
[{'content': 'Biotin is used in the treatment of: \nSelect and explain. \nA. Multiple carboxylase deficiency, B. Keto acid dehydrogenase deficiency, C. Transketolase deficiency, D. Multiple dehydrogenase deficiency', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Multiple carboxylase/biotinidase deficiency:- autosomal recessive disorder due to defect in holocarboxylase synthase or biotinidase deficiency. Clinical features:- -Metabolic ketoacidosis -Diffuse rash -Alopecia -Seizures -Intellectual disability', 'role': 'assistant'}]