This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': 'All are TRUE about Antineutrophil Cytoplasmic Antibodies, EXCEPT: \nSelect and explain. \nA. Proteinase-3, in neutrophil azurophilic granules, is the major cANCA antigen, B. The major target for pANCA is the enzyme myeloperoxidase, C. A pANCA pattern of staining has been associated with nonvasculitic entities such as rheumatic and nonrheumatic autoimmune diseases, D. There are three major categories of ANCA', 'role': 'user'}, {'content': 'Answer: D \nExplanation: There are two major categories of ANCA. Other statements are true. Ref: Harrisons Principles of Internal Medicine, 18th Edition, Page 2786', 'role': 'assistant'}]