This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
[{'content': 'Mech of action of bevacizumab \nSelect and explain. \nA. Inhibitor of HER-2/Neu, B. Inhibitor of VEGF, C. Inhibitor of c-kit, D. None of the above', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Bevacizumab:- Mech of action:- It is a humanized monoclonal antibody that binds VEGF-A and hinders its access to the VEGF receptor, interrupting angiogenic signalling. Uses:- combined with 5-FU, bevacizumab is used in metastatic colorectal cancer. Added to conventional chemotherapy, it improves survival in metastatic non-small cell lung cancer, breast cancer, clear cell renal carcinoma and glioblastoma. Deafness due to neurofibromatosis can be reversed by growth inhibitory effect of bevacizumab. Ref:- kd tripathi; pg num:-871', 'role': 'assistant'}]