This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pharmacology, Subject name: Pharmacology
[{'content': 'Low Vd means \nSelect and explain. \nA. The drug has low half life, B. The drug does not accumulate in tissues, C. The drug has low bioavailability, D. The drug has weak plasma protein binding', 'role': 'user'}, {'content': 'Answer: B \nExplanation: The volume of distribution (V) relates the amount of drug in the body to the concentration of drug (C) in blood or plasmaVd = amount of drug in body/concentration of drug (C)Drugs with low volumes of distribution have much lower concentrations in extravascular tissue than in the vascular compament.Katzung Pharmacology 12th edition Pg: 38', 'role': 'assistant'}]