This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Chromosomal translocation seen in CML is: \nSelect and explain. \nA. 2:08, B. 8:14, C. 9:22, D. 15:17', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Chronic myelogenous leukemia (CML)is characterized by a cytogenetic aberration consisting of a reciprocal translocation between the long arms of chromosomes 22 and 9 . The translocation results in a shoened chromosome 22. This translocation relocates an oncogene called ABL from the long arm of chromosome 9 to a specific breakpoint cluster region (BCR) in the long arm of chromosome 22. The ABL oncogene encodes a tyrosine protein kinase. The resulting BCR/ABL fusion gene encodes a chimeric protein with strong tyrosine kinase activity. The expression of this protein leads to the development of the CML phenotype.', 'role': 'assistant'}]