This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
[{'content': 'Which of the following aminoglycosides has highest nephrotoxicity? \nSelect and explain. \nA. Paramomycin, B. Streptomycin, C. Amikacin, D. Neomycin', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Small amounts that are absorbed from the gut or topical sites are excreted unchanged by kidney. This may accumulate in patients with renal insufficiency-cause fuher kidney damage and ototoxicity. Neomycin is contraindicated if renal function is impaired. ESSENTIALS OF MEDICAL PHARMACOLOGY page 750', 'role': 'assistant'}]