This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Which of the following metabolic abnormality is seen with long term use of loop diuretics? \nSelect and explain. \nA. Metabolic acidosis, B. Metabolic alkalosis, C. Hyperkalemia, D. None of the above', 'role': 'user'}, {'content': 'Answer: B \nExplanation: By inhibiting salt reabsorption in the TAL, loop diuretics increase delivery to the collecting duct. Increased delivery leads to increased secretion of K+ and H+ by the duct, causing hypokalemic metabolic alkalosis. This toxicity is a function of the magnitude of the diuresis and can be reversed by K+ replacement and correction of hypovolemia. Ref: Katzung, 11th edition, Chapter 15.', 'role': 'assistant'}]