This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Gastric carcinoma is associated with all of the following, except? \nSelect and explain. \nA. Inactivation of p53, B. Over expression of C-erb, C. Over expression of C-met, D. Activation of RAS', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Mutated p53 isoforms can generate an autoimmune response. Serum anti-p53 antibodies can serve as a diagnostic and prognostic marker in gastric cancer patients.Amplification of the c-met gene has been demonstrated in scirrhous-type gastric cancers. c-met is overexpressed or amplified in advanced gastric cancers of both the well-differentiated and poorly differentiated types.Ras activation is associated with the development of gastric cancer, but it is rare.', 'role': 'assistant'}]