This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'The pharmacokinetic propeies of a new antihistamine are being studied in normal volunteers during phase I clinical trials. The clearance and half-life of the drug are determined to be 4.0 L/hour and 10 hours, respectively. Which of the following values is the approximate volume of distribution for this drug? \nSelect and explain. \nA. 0.06 L, B. 14 L, C. 45 L, D. 60 L', 'role': 'user'}, {'content': 'Answer: D \nExplanation: The volume of distribution of a drug can be determined using the following equation: t1/2 = (0.693 x Vd)/CL Therefore, 10 hours = (0.693 x Vd)/(4.0 L/hour), 40 hours = 0.693 x Vd, Vd = 58 L which is approximately 60 L.', 'role': 'assistant'}]