This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Bacteriology, Subject name: Microbiology
[{'content': 'Botulism causes \nSelect and explain. \nA. Descending flaccid paralysis, B. Descending spastic paralysis, C. Ascending paralysis, D. Ascending spastic paralysis', 'role': 'user'}, {'content': "Answer: A \nExplanation: Clostridium botulinum produces Type A toxin. It acts by blocking the production or release of acetylcholine at the synapses and neuromuscular junction. Thus block neuromuscular transmission. Onset is marked by diplopia, dysphagia, and dysahria due to cranial nerve involvement. Symmetric descending flaccid paralysis is a characteristic pattern, ending in death by respiratory paralysis. Reference: Textbook of Microbiology; Anathanarayan and paniker's; 10th edition; Page no: 269", 'role': 'assistant'}]