This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Which of the following antimicrobial agents do not require reduction in dose in patients with renal failure? \nSelect and explain. \nA. Rifampicin, B. Fluconazole, C. Vancomycin, D. Imipenem', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Rifampicin is primarily metabolized in the liver and excreted in bile. Rifampicin does not require dosage adjustment in Renal failure. Ref: Essentials of Medical Pharmacology By K D Tripathi, 5th Edition, Pages 667, 700, 719, 721; KDT 6th Edition, Page 741', 'role': 'assistant'}]