This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Primary Open-Angle Glaucoma and Related Conditions, Subject name: Ophthalmology
[{'content': 'MOA of acetazolamide used in glaucoma: \nSelect and explain. \nA. Increase aqueous production, B. Increase uveo-scleral outflow, C. Increase trabecular outflow, D. Decrease aqueous production', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ans. (d) Decrease aqueous productionRef: A.K. Khurana 6th ed. /451-52* ACETAZOLAMIDE is a carbonic anhydrase inhibitor which acts in OAG by decreasing aqueous production.* Carbonic anhydrase derivatives are: Acetazolamide, Dorzolamide, Brinzolamide* Dorzolamide is mildest carbonic anhydrase inhibitor, hence considered as DOC for glaucoma in children.* Alpha-2 agonist (Brimonidine, Apraclonidine) also act by decreasing aqueous production.* Class of drugs which act by increasing outflow:# | Trabecular outflow: Pilocarpine, Epinephrine# | Uveoscleral outflow: PG Analogue (Latanoprost)Must Know TREATMENT OF Glaucoma* First line DOC for ACG: Mannitol* TOC for ACG: Laser iridotomy* DOC for OAG: PG analogue (Latanoprost)* Most powerful anti glaucoma drug: Latano- prost* DOC for OAG in India- Timolol* Safest anti-glaucoma for children- Dorzolamide', 'role': 'assistant'}]