This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'The nitrates which can undergo the ﬁrst-pass metabolism: \nSelect and explain. \nA. Nitroglycerine, B. Pentaerythritol tetranitrate, C. Isosorbide dinitrate, D. All of the above', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Organic nitrates are lipid-soluble: well absorbed from buccal mucosa, intestines and skin. Ingested orally, all except isosorbide mononitrate undergo extensive and variable first pass metabolism in liver.They are rapidly denitrated by a glutathione reductase and a mitochondrial aldehyde dehydrogcnase.\n\xa0\nReference: Essentials of Medical Pharmacology Eighth Edition KD\xa0TRIPATHI\xa0page no 587', 'role': 'assistant'}]