This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
[{'content': 'Predominant osteoblastic secondaries are seen in: \nSelect and explain. \nA. Prostate Ca, B. Breast Ca, C. Bone Ca, D. Stomach Ca', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ref: Robbins Pathologic Basis of Disease, 8th edition. Bone misc tumors chapter Pg: 1205Explanation:The radiographic manifestations of metastases may he purely lytic, purely blastic. or mixed lytic and blastic.In lytic lesions, the metastatic cells secrete substances such as prostaglandins, cytokines, and PTH-related protein that stimulate osteoclast hone resorption; the tumor cells themselves do not directly resorb bone.Lysis of hone tissue rich in growth factors such as TGF-b, IGF-l, FGF, PDGF, and bone morphogenetic proteins, in rum helps create an environment conducive to tumor cell growth.Prostate adenocarcinoma secretes WNT proteins that stimulate osteoblastic hone formation.Most metastases induce a mixed lytic and blastic reactionPrimaries which produce predominantly Lytic bone lesionsCarcinoma of the kidneyCarcinoma of the JuneCarcinoma of ihe gastrointestinal tractMalignant melanomaPrimaries which produce predominantly Sclerotic/Osteoblastic lesionsProstate adenocarcinomaCa ColonCa Breast', 'role': 'assistant'}]