This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Mediator of acute inflammation not derived from the cell is: \nSelect and explain. \nA. Histamine, B. Leukotrienes, C. Cytokines, D. Kinins', 'role': 'user'}, {'content': 'Answer: D \nExplanation: CHEMICAL MEDIATORS OF INFLAMMATION\nAka permeability factors or endogenous mediators of increased vascular permeability.\nThey are broadly classified into 2 groups:\ni. Mediators released by cells.\nii. Mediators originating from plasma.\nCHEMICAL MEDIATORS OF ACUTE INFLAMMATION\nA. Cell-Derived Mediators\n1. Vasoactive amines\nHistamine.\n\n5-hydroxytryptamine.\nNeuropeptides.\n\n2. Arachidonic acid metabolites (Eicosanoids)\ni. Metabolites via the cyclo-oxygenase pathway\n\nProstaglandins.\nThromboxane A2.\nProstacyclin.\nResolvins.\n\nii. Metabolites via a lipo-oxygenase pathway\n\n5-HETE.\nLeukotrienes.\nLipoxins.\n\n3. Lysosomal components (from PM Ms, macrophages)\n4. Platelet-activating factor (PAF)\n5. Cytokines\n\nIL-1\nTNF-α.\nTNF-β.\nIFN-γ.\nChemokines.\n\n6. Free radicals\n\nOxygen metabolites\nNitric oxide\n\nB. Plasma-Derived Mediators (Plasma Proteases)\nProducts of:\n1. The kinin system.\n2. The Clotting system.\n3. The Fibrinolytic system.\n4. The Complement system.', 'role': 'assistant'}]