This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pharmacology, Subject name: Pharmacology
[{'content': 'High plasma protein binding of a drug results in \nSelect and explain. \nA. Less drug interaction, B. High volume of distribution, C. Decreased glomerular filtration, D. Lowers duration of action', 'role': 'user'}, {'content': "Answer: C \nExplanation: * Most drugs bind to plasma proteins in a reversible fashion without translating into a pharmacological response. (Plasma proteins are hence called Silent Receptors) * Acidic drugs bind to Albumin, Basic drugs to alpha1 acid- glycoprotein. * Binding of the drug to plasma protein affects the pharmacokinetic handling of drug by the body. Ref:- HL & KK Sharma's Principles of Pharmacology 3rd Ed; Pg Num:- 48", 'role': 'assistant'}]