This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of lipid, Subject name: Biochemistry
[{'content': 'Which apolipoprotein is responsible for Alzeihmers disease \nSelect and explain. \nA. APOE1, B. APOE2, C. APOE3, D. APOE4', 'role': 'user'}, {'content': 'Answer: D \nExplanation: * Familial AD and Apo-E4 gene: There is an association between patients possessing the apo E4 allele and the incidence of Alzheimer disease. Apparently, apo E4 binds more avidly to beta-amyloid found in neuritic plaques. * Genes identified with AD are that coding for APP, presenilin-1 (chromosome 14), presenilin-2 (chromosome 1) or AD3 (chromosome 14) or AD4 (chromosome 1), and Apo-E4 gene (chromosome 19). * The presence of Apo-E4 gene is the major risk factor for AD. Apo-E2 gene reduces the risk of AD. Ref:- Harper 30/e; pg num:- 275', 'role': 'assistant'}]