This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Lipids, Subject name: Biochemistry
[{'content': "Refsum's disease is characterized by increased levels of \nSelect and explain. \nA. Phytanic acid, B. Ascorbic acid, C. Acetic acid, D. None", 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. a (Phytanic acid). (Ref. Harper, Biochemistry, 25th ed., 248)REFSUM'S DISEASE is a rare neurologic disorder due to a defect (absent phytanic acid oxidase enzyme) that causes the accumulation of phytanic acid, which is found in plant foodstuffs and blocks beta-oxidation.DISORDERS DUE TO PEROXISOMAL ABNORMALITIES# Zellweger syndrome- Neonatal adrenoleukodystrophy- Infantile Refsum disease# Hyperpipecolic acidemia- Acatalasemia- Adrenoleukodystrophy# Pseudo-adrenoleukodystrophy- Hyperoxaluria type- Pseudo-Zellweger syndrome# Rhizomelic chondrodysplasia punctata- Glutaryl-CoAoxidase deficiency (Note: Zellweger syndrome is the most severe and infantile Refsum disease is the least severe form)", 'role': 'assistant'}]