This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'In the management of diabetes mellitus, lactic acidosis is commonly caused by which of the following: March 2005 \nSelect and explain. \nA. Tolbutamide, B. Glipizide, C. Pioglitazone, D. Metformin', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ans. D: Metformin Medicinal and toxic causes of lactic acidosis Acetaminophen Alcohols and glycols (ethanol, ethylene glycol, methanol, propylene glycol) Antiretroviral nucleoside analogs (zidovudine, didanosine, lamivudine) Beta-adrenergic agents (epinephrine, ritodrine, terbutaline) Biguanides (phenformin, metformin) Cocaine Cyanogenic compounds (cyanide, aliphatic nitriles, nitroprusside) Sugars and sugar alcohols (fructose, sorbitol, and xylitol), Salicylates Strychnine Sulfasalazine Valproic acid Diethyl ether, 5-fluorouracil Halothane, propofol Isoniazid', 'role': 'assistant'}]