This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Opioids, Subject name: Pharmacology
[{'content': 'In methyl alcohol poisoning there is CNS depression, cardiac depression and optic nerve atrophy. These effects are produced due to: \nSelect and explain. \nA. Formaldehyde and formic acid, B. Acetaldehyde, C. Pyridine, D. Acetic acid', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. (A) Formaldehyde and formic acid(Ref: Katzung 11/e p1024; KDT 8/e p422)Methyl alcohol (methanol) is metabolized to formaldehyde by alcohol dehydrogenase and then to formic acid by aldehyde dehydrogenase. These compounds are responsible for the toxicity. Formic acid can lead to coma and blindness also. Therefore, inhibitor of alcohol dehydrogenase, Fomepizole is used for treatment of methanol overdose.', 'role': 'assistant'}]