This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous (Bio-Chemistry), Subject name: Biochemistry
[{'content': 'Buffering is maximum when \nSelect and explain. \nA. pH = pKa, B. pH > pKa, C. pH < pKa, D. No relation to pKa', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans: a (pH = pKa) Ref: Vasudevan 4'k ecU p.346At values close to pKa, the buffer solution resists changes in pH most effectively. Buffering is the tendency of a solution to resist a change in pH more effectively after addition of a strong acid or base tha n does equal volume of water. Solutions of weak acids and their conjugate bases, and vice versa exhibit buffering. Strong acid /bases do not have buffering quality as great as the weak acid/ bases. pKa refers to the pH at which the concentration of acid equals that of base.* At pH = pKa, the solution would contain acid and base in equal amounts, and therefore would resist a change most effectively in either direction.Note:-The effective range of a buffer is one pH unit higher or lower than pKa.", 'role': 'assistant'}]