This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Chromosome inversion is: \nSelect and explain. \nA. A portion of the chromosome is missing or deleted, B. A portion of the chromosome is duplicated, resulting in extragenetic material, C. A single chromosome undergoes breakage and rearranges within itself, D. A portion of one chromosome has been deleted from its normal place and inserted into another chromosome', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Inversion: Occur when there are two interstitial of a\xa0single chromosome breaks in and the segment reunites & rearranged after a complete turnaround.\nOption A - Deletion e.g. Wolf-Hirschhorn syndrome, Jacobsen syndrome, also called the terminal IIq deletion disorder.\nOption B - Duplication - e.g. Charcot-Marie-Tooth disease type 1A\nOption D - Insertion\nOther structural disorders of chromosomes:\nRings:\n\nA portion of a chromosome has broken off and formed a circle or ring.\nThis can happen with or without loss of genetic material.\n\nIsochromosome:\n\nFormed by the mirror image copy of a chromosome segment including the centromere.\n\nAneuploidy:\n\nNumerical disorder of chromosomes.\nMissing a chromosome from a pair is called monosomy and presence of more than two chromosomes of a pair (trisomy, tetrasomy, etc.)', 'role': 'assistant'}]