This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Ophthalmology
[{'content': 'Purely depolorizing cells in optic pathway ? \nSelect and explain. \nA. Amacrine cells, B. Rods & cones, C. Bipolar cells, D. Horizontal cells', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Amacrine cells The responses of the rods, cones and horizontal cells are hyperpolarizing. Bipolar cells may show either hyperpolarization or depolarization. All these cells develop only graded local potentials, i.e., nonpropagated, decremental, does not follow all or none law. These cells do not develop action potential. The only cell which develops propagated action potential is ganglion cells and the response is always depolarizing. Otherwise, they remains in inactive state. Amacrine cells produce depolarizing potential and spikes. Rods and cones release glutamate at their synapses with the bipolar cells. Amacrine cells secrete at least eight types of transmitter substances, including GABA, glycine, dopamine, acetylcholine and indolamine, all of which normally function as inhibitory neurotransmitters. The transmitters of the bipolar cells and horizontal cells are unclear.", 'role': 'assistant'}]