This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': "Which among the following condition is positive for double stranded DNA antibody? \nSelect and explain. \nA. SLE, B. Sjogren's syndrome, C. Scleroderma, D. Mixed Connective Tissue Disorder", 'role': 'user'}, {'content': "Answer: A \nExplanation: Serum antinuclear antibodies (ANAs) are found in nearly all individuals with active SLE. Antibodies to native double-stranded DNA (dsDNA) are relatively specific for the diagnosis of SLE. Anti-SSA or anti-SSB antibodies are seen in Sjogren's syndrome. Topoisomerase I antibodies (also known as Scl-70), Anticentromere antibodies, Fibrillarin antibodies and antibodies to ribonucleoprotein (RNP) are present in scleroderma. Anti-U1-RNP antibodies, and antibodies against U1-70 kd small nuclear ribonucleoprotein (snRNP) are characteristic of mixed connective tissue disorder (MCTD).", 'role': 'assistant'}]