This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'Malate shuttle is important in ________ \nSelect and explain. \nA. Glycolysis only, B. Glycogenolysis, C. Glycolysis and gluconeogenesis, D. Glycogen synthesis', 'role': 'user'}, {'content': 'Answer: C \nExplanation: NADH\xa0cannot\xa0penetrate\xa0the\xa0mitochondrial membrane, but it is produced continuously in the cytosol by 3-phosphoglyceraldehyde dehydrogenase, an enzyme in the glycolysis sequence.\nThe transfer of reducing equivalents is carried out by using the various shuttle systems.\nMalate shuttle system is of more universal utility. Used to transport NADH from cytosol to mitochondria.\nIn glycolysis, the impermeable NADH produced in the cytosol are taken up into mitochondria for oxidation via malate shuttle.\nIn\xa0gluconeogenesis, pyruvate in the mitochondria yields impermeable oxaloacetate, which gets translocated to the cystol via malate shuttle for the sythesis of glucose.\n\nHarper 30th edition\xa0 Pg-125,126,173', 'role': 'assistant'}]