This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Physiology
[{'content': 'Aldosterone receptors are present in all except: \nSelect and explain. \nA. Liver, B. Colon, C. Hippocampus, D. Distal nephron', 'role': 'user'}, {'content': 'Answer: A \nExplanation: A i.e. LiverAldosterone (or mineralocoicoid) receptor (MR, MLR, MCR) is expressed in central nervous system (hippocampus), hea, kidney, colon, brown adipose tissue and sweat glands but not not in liverQ.It is a steroid hormone receptor that belongs to nuclear receptor subfamily 3, group C, member 2 (NR3C2). It is activated by mineralocoicoids eg. aldosterone & deoxycoicosterone, as well as by glucocoicoids (such as coisol & coisone) and some progestins.Its activation in epithelial cells leads to expression of proteins regulating ionic and water transpo (mainly epithelial sodium channels. ENaC, Na+ - K+ pump, serum & glucocoicoid induced kinase or SGK1) resulting in absorption of Na+ causing increased ECF volume & BP, and an excretion of K+ to maintain a normal salt concentration in body.', 'role': 'assistant'}]