This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Growth factor oncogene is - \nSelect and explain. \nA. myc, B. fos, C. sis, D. jun', 'role': 'user'}, {'content': "Answer: C \nExplanation: Sis oncogene is a growth factor.\nMyc, jun and fos oncogenes are nuclear regulatory proteins\n\n\nFollowing information have been added in 8th/ e of Robbin's\xa0\nmiRNA and cancer\n\nIt has already been explained in genetics that miRNA is a gene-silencing RNA, i.e. it inhibits gene expression at post-transcription level.\nSo, miRNA can be involved in tumorigenesis in two ways :\n\n\nReduced activity of miRNA that inhibits translation of an oncogene will result in excess of oncoprotein and tumorigenesis. For example, mRNA inhibits expression of anti-apoptotic gene Bcl 2. Reduced activity of this miRNA results in over-expression of Bcl-2 which inhibits apoptosis and results in leukaemia and lymphoma. Similarly, miRNA mediated upregulation of Ras and Myc oncogenes has been detected in lung tumor and B-cell leukemia, respectively.\nOn the other hand, overactivity of miRNA that targets a tumor suppression gene will result in inhibition of expression of tumor suppressor gene and tumorigenesis.", 'role': 'assistant'}]