This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Breast, Subject name: Pathology
[{'content': 'Somatic mutation E17K in the PH domain of AKT-1 gene mutation is associated with? \nSelect and explain. \nA. Stomach, B. Breast, C. Ovary, D. Pancreas', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Ans. (b) Breast(Ref: Atlasgeneticsoncology.org/Genes/AKT1)Hyper-activation of AKT1 has been found associated to several human cancers:*Thyroid carcinoma*Breast carcinoma*Non-small cell lung carcinoma*Gastric carcinomaNow coming to question: Somatic mutation E17K occurs in the PH domain of AKT1 in 8% of human breast cancers. This mutation also occurs in 6% of colorectal cancers.', 'role': 'assistant'}]