This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Lipids, Subject name: Biochemistry
[{'content': 'Sphingolipids are chiefly accumulated in: \nSelect and explain. \nA. CNS, B. Adipose tissue, C. Cardiac muscle, D. Skeletal muscles', 'role': 'user'}, {'content': "Answer: A \nExplanation: (CNS): Ref: 11-RS, 110-NMS (307-8 U.S 3rd)SPHINGOLIPIDS: - They comprise another group of lipids found in biological membrane specially in the tissues of nervous system. There are three types of sphingolipids - sphingomyelin, cerebrosides, gangliosides about 6% of membrane lipids of grey matter cells in the brain and gangliosidesSPHINGOLIPIDOSISDiseaseLipid accumulatedPrimary organ affected1. Niemann-Pick diseaseSphingoymelinBrain, Liver, Spleen2. Gaucher's diseaseGlucocerebrosideBrain, Liver, Spleen3. Krabbe's diseaseGalactocerebrosideBrain4. Metachromic leukodystrophyb-Sulfagalactoserebrosidase ceramide trihexosideBrainKidney5. Fabry's disease6. Tay-Sach's diseaseGanglioside GM2Brain", 'role': 'assistant'}]