This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Diabetes Mellitus, Subject name: Medicine
[{'content': 'Which of the following sulfonylureas cannot be used in patients with kidney failure? \nSelect and explain. \nA. Glyburide, B. Glipizide, C. Gliclazide, D. Glimepiride', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Glyburide should not be used in patients with liver disease and CKD due to risk of hypoglycaemia. Glipizide, Gliclazide and Glimepiride are metabolised by liver and hence can be used in patients with CKD.', 'role': 'assistant'}]