This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
[{'content': 'Which of the following is not true regarding super-antigens- \nSelect and explain. \nA. Bind T cells irrespective of antigen specificity of TCR, B. Bind directly to both MHC II and T cell receptor causing T cell activation, C. Bind to cleft (or antigen binding groove) in the MHC H molecule, D. Binds directly to lateral aspect of T cell receptor', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Reference :Robbins basic pathology 9th edition pg 110:An additional group of secreted bacterial proteins called superantigens also cause a syndrome similar to septic shock (e.g., toxic shock syndrome). Superantigens are polyclonal T-lymphocyte activators that induce T cells to release high levels of cytokines, which in turn results in a variety of clinical manifestations, ranging from a diffuse rash to vaso- dilation, hypotension, and death.', 'role': 'assistant'}]