This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Which is the most common mutation in Hereditary spherocytosis \nSelect and explain. \nA. Glycophorin, B. Band 3, C. Ankyrin, D. Spectrin', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ankyrin mutation is most common in HS. Spectrin mutation correlates with severity of anemia in HS.', 'role': 'assistant'}]