This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Fetal circulation, Subject name: Gynaecology & Obstetrics
[{'content': 'What is true of fetal hematopoiesis in the course of pregnancy? \nSelect and explain. \nA. Rise in MCV, B. Rise in reticulocyte count, C. Rise in Hemoglobin content, D. Decrease in blood volume', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Fetal hematopoiesis: yolk sac - fetal liver - fetal bone marrow. The first fetal erythrocytes are nucleated and macrocytic. MCV is 180 fL and normally decreases to 105 to 115 fL. As the fetus grows, the blood volume in fetoplacental circulation increases. The fetalhemoglobin concentration increases from 12 gm/dL in mid pregnancy to 18 gm/dL at term. The retic count decreases to about 4 to 5 % at term. The RBC life span increases to 90 days at term.', 'role': 'assistant'}]