This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Urinary tract, Subject name: Pathology
[{'content': 'Chromophobe variant of renal cell is associated with - \nSelect and explain. \nA. VHL gene mutations, B. Trisomy of 7 and 17 (+7, +17), C. 3 p deletions (3p-), D. Monosomy of 1 and Y (-1, -Y)', 'role': 'user'}, {'content': 'Answer: D \nExplanation: These tumors are unique in having multiple losses of entire chromosomes, including chromosomes 1, 2, 6, 10, 13, 17, and 21. Thus, they show extreme hypodiploidy. Because of multiple losses, the "critical hit" has not been determined. Ref: Robbins basic pathology 9th edition page548', 'role': 'assistant'}]