This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Metoclopromide - \nSelect and explain. \nA. Inhibits cholinergic smooth muscle stimulation in the Gastrointestinal tract, B. Increases lower esophagial sphinctor pressure, C. Stimulates D2 receptors, D. Enhances colonic motility', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e., Increases lower esophageal sphinctor pressure Effects of metoclopramide on GIT Metoclopramide has 5-HT4 agonistic and D2 antagonistic activity in GIT. o These two actions result in enhanced cholinergic smooth muscle stimulation. o Metoclopramide has prominent effect on upper GIT i) Increases gastric peristalsis ii) Relaxes pylorus and first pa of duodenum iii) Tone of lower esophageal sphinctor is increased o Metoclopramide has no or minimal effect on lower GIT --> increases intestinal motility to some extent, but has no action on colonic motility.", 'role': 'assistant'}]