This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Which of the following metabolic abnormality is seen with long term use of spironolactone? \nSelect and explain. \nA. Metabolic acidosis, B. Metabolic alkalosis, C. Hyperkalemia, D. None of the above', 'role': 'user'}, {'content': 'Answer: A \nExplanation: By inhibiting H+ secretion in parallel with K+ secretion, the K+-sparing diuretics can cause acidosis similar to that seen with type IV renal tubular acidosis. Ref: Katzung, 11th edition, Chapter 15.', 'role': 'assistant'}]