This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.N.S, Subject name: Pharmacology
[{'content': 'Benzodiazepine acts through: \nSelect and explain. \nA. GABAA, B. GABAB, C. GABAC, D. GABAD', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans: a (GABA A) Ref: KDT, 6 ed, p. 394The benzodiazepine receptor modulates GABA A receptor in either direction. Agonists like diazepam facilitate, while inverse agonists like DMCM hinder GABA A mediated Cl- channel opening and benzodiazepine antagonist like flumazenil block the action of both.GABAA BZD Receptor--Cl Channel complexDrugs acting on GABA receptor gated chloride channel:Muscimol: GABAa agonistBicuculline: GABAa competitive antagonistBarbiturate : agonist at allosteric site (?picrotoxin site) - prolong GABA action ie, open cl- channel.Picrotoxin: blocks cl- channel competitivelyBenzodiazepine: agonist at allosteric BZD site- facilitate GABA actionsscarboline (DMCM): inverse agonist at BZD site- impede GABA action.Flumazenil: competitive antagonist at BZD site.Remember:GABAB: G protein coupled receptor. Hyperpolarizes neurons by increasing K+conductance.Baclofen GABAB agonistSaclofen: GABAB receptor blocker', 'role': 'assistant'}]