This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General Pharmacology, Subject name: Pharmacology
[{'content': 'Causes for reduced bioavailability include: \nSelect and explain. \nA. High first pass metabolism, B. Increased absorption, C. IV drug administration, D. High lipid solubility', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. (A) High first pass metabolism(Ref: KDT 8th/e p22)The causes of low bioavailability are:1. Reduced absorption2. High first pass metabolism', 'role': 'assistant'}]