This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Emesis receptor is - \nSelect and explain. \nA. 51-ITI, B. 511T2, C. 51-IT3, D. 5HT4', 'role': 'user'}, {'content': "Answer: C \nExplanation: Ans. is 'c' i.e., 5HT3 Vomiting centre and nucleus of tractus solitarius contain muscarinic, cholinergic and histamine H, receptors. CTZ is located in area postrema (outside BBB) and contains Dopamine D2, opioid & serotonine 5-HT3 receptors. o So, antiemetic that act on vomiting centre have antimuscarinic and antihistaminic action --> can allete vomiting from any cause. o Drugs acting on CTZ have Dopamine D, antagonistic and 5-HT3 antagonistic action --> effective only in vomiting mediated by stimulation of chemoreceptors (by morphine, cytotoxic drugs, digoxin).", 'role': 'assistant'}]