This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'First step in cholesterol synthesis is inhibited by ? \nSelect and explain. \nA. Niacin, B. Fenofibrate, C. Cholestramine, D. Lovastatin', 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans. is 'd' i.e., Lovastatin Statins (Lovastatin) competitively inhibit the conversion of HMG-CoA to mevalonate (rate limiting step in cholesterol synthesis) by inhibiting the enzyme HMG-CoA reductase.Hvpolipidemic drugs HMG-CoA reductase inhibitors (statins) - Lovastatin, Simvastatin, Pravastatin, Atorvastatin, Rosuvastatin.Bile acid sequestrants (Resins) - cholestyramine, colestipol.Activate lipoprotein lipase (fabric acid derivatives) - clofibrate, gemfibrozil, bezafibrate, fenofibrate. 4.Inhibit lipolysis and triglyceride synthesis - Nicotinic acid.Other - Probucol, Gugulipid, Ezetimibe, Avasimibe, Torcetrapib.Ezetimibe inhibits intestinal cholesterole absorption.Avasimibe inhibits enzyme acyl Coenzyme A : cholesterol acyl transferase-1 (A CAT-1) which causes esterification of cholesterol.Torcetrapib inhibits cholesterol ester triglyceride transpo protein -4 T HDL cholesterol.", 'role': 'assistant'}]