This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': "In Gaucher's disease there is accumulation of --- inside the cells – \nSelect and explain. \nA. Galactosidases, B. Sphingomyeline, C. Glucosidases, D. Cerebrosides", 'role': 'user'}, {'content': 'Answer: D \nExplanation: Lysosomal storage diseases \n\nLysosomes are key components of the intracellular digestive tract.\nThey contain a battery of hydrolytic enzymes.\nThese hydrolytic enzymes catalyze the breakdown of a variety of complex macromolecules.\nWith an inherited deficiency of a functional lysosomal enzyme, catabolism of its substrate remains incomplete, leading to accumulation of the partially degraded insoluble metabolite within the lysosomes.\nStuffed with incompletely digested macromolecules, these organelles become large and numerous enough to\n\ninterfeie with normal cell functions, giving rise to the lysosomal storage disorders.\nImportant lysosomal storage diseases', 'role': 'assistant'}]