This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'Differential expression of the same gene depending on parent of origin is referred to as – \nSelect and explain. \nA. Genomic imprinting, B. Mosaicism, C. Anticipation, D. Nonpenetrance', 'role': 'user'}, {'content': 'Answer: A \nExplanation: The phenomenon referred to as genomic imprinting leads to pereferential expression of an allele depending on its parental origin - Harrisons\n\nGenomic imprinting\n\nHuman inherits two copies of each gene, i.e. two alleles, from homologous maternal and paternal chromosomes.\nThere is no functional difference between the genes derived from the mother or the father.\nBut, with respect to some genes, there are functional differences between the paternal gene and maternal gene.\nThese differences result from an epigenetic process, called genomic imprinting.\nIn most cases, genomic imprinting selectively inactivates either the maternal or paternal allele.\n\n1. Maternal genomic imprinting\n\nSelective inactivation of the maternal allele\nAn example is an Angelman syndrome\n\n2. Paternal genomic imprinting\n\nSelective inactivation of paternal allele.\nAn example is Prader-Willi syndrome.', 'role': 'assistant'}]