This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Which of the following agent is NOT used in management of bronchial asthma: March 2012, March 2013 \nSelect and explain. \nA. Phospho-di-esterase inhibitors, B. Steroids, C. Beta agonists, D. Cholinergic drugs', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ans: D i.e. Cholinergic drugs Drugs and uses Methylxanthines (theophylline, aminophylline, doxophylline etc.) acts by 3 distinct cellular actions. (i) Release of calcium from sarcoplasmic reticulum, (ii) inhibition of phosphodiesterase and (iii) blockade of adenosine receptors. Coicosteroids benefit in asthma by reducing bronchial hyper-reactivity, mucosal edema and by suppressing inflammatory response to antigen: antibody reaction or other trigger stimuli. Beta agonists/sympathomimetics causes bronchodilatation through beta2 receptor stimulation --n increased cAMP formation in bronchial muscle cell relaxation. Cholinergic drugs will precipitate asthma, by causing bronchoconstriction (instead anticholinergic drugs/atropine is used, which causes bronchodilatation by blocking cholinergic constrictor tone).', 'role': 'assistant'}]