This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Single Gene Disorders, Subject name: Pathology
[{'content': 'A patient has been diagnosed with Marfan syndrome. Which of the following is the most common cause of death in these patients? \nSelect and explain. \nA. Liver disease, B. Myocardial infarction, C. Recurrent infection, D. Aoic disease', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Marfan syndrome Autosomal dominant Defect in an extracellular glycoprotein called fibrillin-1. Loss of fibrillin- Clinical manifestations of Marfan syndrome. Loss of structural suppo in microfibril rich connective tissue and excessive activation of TGF-b signaling. Skeletal abnormalities Unusually tall Exceptionally long extremities and long, Tapering fingers and toes. Cardiovascular lesions Mitral valve prolapse Aoic Dissection.', 'role': 'assistant'}]