This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': 'Wilson’s disease is characterised by all except? \nSelect and explain. \nA. The defective gene is ATP 7A, B. Neurological features include Parkinsonian features and Ataxia, C. Kayser-Fleischer rings and sunflower cataracts are typical eye findings, D. Liver biopsy is confirmatory for the diagnosis', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Option 1 - ATP7A gene defect leads to Menke’s disease.\n\xa0\n\xa0Option\xa02\xa0- Wilson disease\xa0leads to copper accumulation leading to reduced concentration of Ceruloplasmin.\xa0Copper is deposited mainly in the liver and brain. Parkinsonism, ataxia, dystonia, subcortical dementia, seizures, psychosis and migraine are all neurological features.\xa0\n\xa0\nOption\xa03 -\xa0Kayser-Fleischer rings (copper in Descemet’s membrane in eye) and sunflower cataracts are typical eye findings.\xa0\n\xa0\nOption\xa04 -\xa0Eventhough reduced ceruloplasmin and raised urinary copper may suggest the possibility of Wilson’s, the diagnosis is confirmed using a liver biopsy to estimate copper levels.', 'role': 'assistant'}]