This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
[{'content': 'Apoptosis is inhibited by \nSelect and explain. \nA. p53, B. N-myC, C. RAS, D. BCl-2', 'role': 'user'}, {'content': 'Answer: D \nExplanation: The integrity of the mitochondrial outer membrane is regulated by pro-apoptotic and anti-apoptotic members of the BCL2 family of proteins. The pro-apoptotic proteins BAX and BAK are directly promoting mitochondrial permeabilization. Their action is inhibited by the anti-apoptotic proteins BCL2 and BCL-XL. The third set of proteins, the so-called BH3-only proteins, which include BAD, BID, and PUMA, regulate the balance between the pro- and anti-apoptotic members of the BCL2 family.( Robbins Basic Pathology, 9th edition, page 189 )', 'role': 'assistant'}]