This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'A 50 year old male patient presents to the clinic for routine checkup. He is hypertensive and a type 2 diabetic. Lab investigations reveal plasma cholesterol levels 5.8 mmol/L and RBS 180 mg/dl. Which of the following agents can be used in this patient? \nSelect and explain. \nA. Statins, B. Fibrates, C. Nicotinic acid, D. All of the above', 'role': 'user'}, {'content': 'Answer: D \nExplanation: When diet changes fail, hypolipidemic drugs can reduce serum cholesterol & triacylglycerol. A family of drugs known as statins have proved highly efficacious in lowering plasma cholesterol and preventing\xa0 heart disease.\nStatins act by inhibiting HMG-CoA\xa0 reductase and up-regulating LDL receptor activity. Examples currently in use include atorvastatin, simvastatin, fluvastatin and pravastatin.\nEzetimibe reduces blood cholesterol levels by inhibiting the absorption of cholesterol by the intestine by blocking uptake via the Niemann-Pick C-like 1 protein.\nOther drugs used include fibrates such as clofibrate, gemfibrozil, and nicotinic acid, which act mainly to lower plasma triacylglycerols by decreasing the secretion of triacylglycerol and cholesterol-containing VLDL by the liver.\xa0\nHigh plasma cholesterol levels\xa0are >5.2 mmol/L.\nReference: HARPERS ILLUSTRATED BIOCHEMISTRY30th ed Page no 276', 'role': 'assistant'}]