This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Intracanalicular hepatic apparatus is affected by-a) Alagille syndromeb) Cystic fibrosisc) Congential hepatic fibrosisd) Caroli diseasee) Polycystic liver disease \nSelect and explain. \nA. bcde, B. abd, C. abcd, D. acde', 'role': 'user'}, {'content': 'Answer: A \nExplanation: A heterogenous group of lesions causing altered architechture of intrahepatic billiary tree. They are :\n\tVon Meyenburg complexes\xa0\xa0\n\tCongenital hepatic fibrosis\n\tPolycystic liver disease\n\tCaroli disease\nAlagille syndrome is absence of portal tract, bile duct peculiar facies, vertebral anomalies and CVS defects.\nIn cystic fibrosis — bile canaliculi are plugged by mucinous material when longstanding, can cause biliary cirrhosis. It cause ductular proliferation and portal inflammation.', 'role': 'assistant'}]