This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
[{'content': 'What constitutes malpighian layer of skin? \nSelect and explain. \nA. Corneum lucidum, B. Corneum spinosum, C. Spinosum and basale, D. Basale granulosum', 'role': 'user'}, {'content': "Answer: C \nExplanation: Ref. Rook's Textbook of Dermatology, Pg 35\n\xa0\nHistology of skin\n\nBasal layer:\n\nMitotically active, produces other keratinocytes\nContains low molecular weight keratin\nSeparated from dermis by continuous basal membrane; keratinocytes are attached to this membrane by hemidesmosomes\nAlso contains melanocytes\n\n\n\n\xa0\n\nSquamous layer (stratum spinosum):\n\nAlso called prickle or malpighian layer\nHas several layers of cells, larger than basal layer, which become flat and eosinophilic as they approach the surface due to an increase in keratin and reduction in ribosomes\nMay have clear vacuolated cytoplasm\nCells are attached to each other by fine spiny bridges with central dot-like desmosomes (Bizzozero’s nodule)\nLoss of spiny bridges causes acantholysis\n\n\n\n\xa0\n\nGranular layer (stratum granulosum):\n\n1 - 3 layers of flattened cells with intensely basophilic keratohyaline granules, which contain precursors of filaggrin protein, which causes aggregation of keratin filaments\nMalphigian layer includes – spinosum and granulosum\n\n\n\n\xa0\n\nStratum lucidum:\n\nPresent only in soles and palms, between granular and cornified layer\nHomogenous eosinophilic zone\n\n\n\n\xa0\n\nCornified layer (stratum corneum):\n\nAlso called horny layer\nBasket weave pattern of multiple layers of polyhedral cells without nuclei\nRegion is thicker and more compact in acral region (peripheral body-limbs, fingers, ears)\n\n\n\n\xa0\n\nRete ridges:\n\nUndulating forms of epidermis and dermal papillae at dermoepidermal junction - flattens with aging", 'role': 'assistant'}]