This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': '40 year old patient presented with excessive skin pigmentation of face neck and extensor aspects of forearms having diabetes and ahropathy and Dyspnoea on exeion, class III. Clinical examination revealed hepatosplenomegaly and spider angioma. All are true about this condition, except: \nSelect and explain. \nA. Caused by a mutant gene termed HFE, B. Risk of hepatocellular carcinoma is very high, C. Females are commonly affected, D. The most common cardiac manifestation is CCF', 'role': 'user'}, {'content': 'Answer: C \nExplanation: The diagnosis is hemochromatosis. Major manifestations of haemocromatosis are cirrhosis, diabetes, ahritis, cardiomyopathy, hypogonadism. Males are commonly involved than females, as females have regular mentraul periods where there is a blood loss.', 'role': 'assistant'}]