This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
[{'content': 'Which of the following antihistaminic is free of arrhythmogenic potential? \nSelect and explain. \nA. Terfenadine, B. Fexofenadine, C. Loratadine, D. Ebastine', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Loratidine Loratidine is paially metabolized by CYP3A4 to an active metabolite with a longer T1/2 of 17 hours but in contrast to terfenadine/astemizole, it has not produced cardiac arrhythmia in overdose.', 'role': 'assistant'}]