This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
[{'content': 'Which of the following is the most significant risk factor for development of gastric carcinoma \nSelect and explain. \nA. Paneth cell metaplasia, B. Pyloric metaplasia, C. Intestinal metaplasia, D. Ciliated metaplasia', 'role': 'user'}, {'content': 'Answer: C \nExplanation: None', 'role': 'assistant'}]