This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Medicine
[{'content': 'Cause ofvasodilatation in spider nevi- \nSelect and explain. \nA. Estrogen, B. Testosterone, C. Hepatotoxins, D. FSH', 'role': 'user'}, {'content': 'Answer: A \nExplanation: The dilation, in turn, is caused by increased estrogen levels in the blood. Individuals with significant liver disease also show many spider angiomas, as their liver cannot metabolize circulating estrogens, specifically estrone, which derives from the androgen androstenedione. Ref Davidson edition23rd pg 869', 'role': 'assistant'}]