This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous (Bio-Chemistry), Subject name: Biochemistry
[{'content': 'Rate Limiting enzyme for Cholesterol synthesis is \nSelect and explain. \nA. HMG Co-A synthase, B. Mevalonate kinase, C. HMG Co-A reductase, D. L-acyl cholesterol transferase', 'role': 'user'}, {'content': 'Answer: C \nExplanation: (C) HMG Co-A reductase# 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase is the rate-controlling enzyme of the mevalonate pathway, the metabolic pathway that produces cholesterol and ther isoprenoids.Bio synthesis of Lipids - Multiple Steps IMPRTANT RATE-LIMITING ENZYME REACTIONSUrea cycleCarbamoyl phosphate synthetase IGlycolysisPFK-1GluconeogenesisFructose-1,6-bisphosphatase (reverses PFK-1 step)TCA cycleIsocitrate DHGlycogen synthesisGlycogen synthaseGlycogenolysisGlycogen phosphorylase (requires pryridoxal phosphate, the active form of B6)HMP shuntG6PD (deficient in "hemolysis IS PAIN" - INH, sulfonamides, primaquine, aspirin, ibuprofen, nitrofurantoin)De novo pyrimidine synthesisCarbamoyl phosphate synthetase li (combined orotic acid phosphoribosyltransferase/ orotidine-5-phosphate decarboxylase)De novo purine synthesisGlutamine-PRPP amidotransferase.Fatty acid synthesisFatty acid oxidationAcetyl-CoA carboxylase (ACC)Carnitine acyltransferase IKetogenesisHMG-CoA synthaseCatecholamine synthesisTyrosine hydroxylaseCholesterol synthesisHMG-CoA reductase (blocked by statins)', 'role': 'assistant'}]