This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Contraceptives, Subject name: Gynaecology & Obstetrics
[{'content': 'Absolute contraindication of HRT is? \nSelect and explain. \nA. Endometriosis, B. Osteoarthritis, C. Heart disease, D. Breast carcinoma', 'role': 'user'}, {'content': 'Answer: D \nExplanation: ANSWER: (D) Breast cancerREF: Harrisons 18th ed edition chapter 348Contraindications to HT should be assessed routinely and include unexplained vaginal bleeding, active liver disease, venous thromboembolism, history of endometrial cancer (except stage 1 without deep invasion) or breast cancer, and history of EURHD, stroke, transient ischemic attack, or diabetes.Relative contraindications include hypertriglyceridemia (>400 mg/dl) and active gallbladder disease; in such cases, transdermal estrogen may be an option', 'role': 'assistant'}]