This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Diabetes Mellitus, Subject name: Medicine
[{'content': 'Which sulfonylurea drug has the highest insulinotropic potency? \nSelect and explain. \nA. Glyburide, B. Glipizide, C. Glimepiride, D. Gliclazide', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Sulfonylureas act on receptors in pancreatic beta cells resulting in closure of potassium cells. This results in depolarization of Beta cell and release of insulin. Glyburide has the highest affinity/ insulinotropic action while tolbutamide has least affinity.', 'role': 'assistant'}]