This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Intestinal Polyps, Colon & Anal Cancer, Subject name: Pathology
[{'content': 'In Peutz-Jeghers syndrome, polyps are mainly seen in: \nSelect and explain. \nA. Rectum, B. Colon, C. Esophagus, D. Jejunum', 'role': 'user'}, {'content': 'Answer: D \nExplanation: In Peutz-Jeghers syndrome, polyps are mainly seen in Jejunum Peutz-Jeghers syndrome Autosomal dominant disorder Most common in small intestine- Jejunum Germ line loss of function mutations in LKB1/STK11 gene are present May occur in stomach, colon & with much lower frequency in bladder and lungs Multiple gastrointestinal hamaomatous polyps + Mucocutaneous hyperpigmentation Gross- Polyps are large & pedunculated with lobulated contour Histologic findings : characterized by proliferation of the muscularis mucosae to form branching configurations covered by hyperophic, but otherwise normal mucosa', 'role': 'assistant'}]