This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cardiovascular system, Subject name: Pathology
[{'content': "With reference to neoplasia, the term 'tumor progression means \nSelect and explain. \nA. Spread of cancer to distant sites, B. Rate of growth of tumors, C. Abi1ity of cancer cells to resemble their normal counterpa, D. Sequential appearnace of features of increasing malignancy", 'role': 'user'}, {'content': 'Answer: D \nExplanation: Multi step.theory of carcinogenesis Phy.attributes are .self sufficient in growth signal .local invasion ,metastasis .karyotic pattern .hormonal response .response to Anti malignant drugs Evading apoptosis All these acquired in a step wise fashion This phenomenon is tumour progression', 'role': 'assistant'}]