This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology and breast, Subject name: Surgery
[{'content': 'The most impoant prognostic factor in breast carcinoma is \nSelect and explain. \nA. Histological grade of the tumor, B. Stage of the tumor at the time of diagnosis, C. Status of estrogen and progesterone receptors, D. Over expression of p-53 tumour suppressor gene', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Stage I and II has got better prognosis. Spread to axillary nodes is the most impoant prognostic indicator. Age: Younger the age worser the prognosis. Sex: Carcinoma male breast has got worser prognosis compared to female breast. Because of early spread in carcinoma male breast. Atrophic scirrhous has got best prognosis. Medullary carcinoma has got better prognosis than scirrhous carcinoma because of lymphocytic infi ltration. Invasive carcinoma has got worser prognosis. Inflammatory carcinoma breast has worst prognosis. Ref; (page no;559 ) 5th edition of SRB&;S manual of Surgery', 'role': 'assistant'}]