This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Adverse Drug Effect, Subject name: Pharmacology
[{'content': 'Which antipsychotic has maximum hypotensive side effect? \nSelect and explain. \nA. Flufenazine, B. Trifluoperazine, C. Thioridazine, D. Haioperidol.', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ref: Goodman 3 Gill man. The pharmacological basis of therapeutics, 12\'" edition, Pg No. 440 Basic and clinical Pharmacology by Betram Katzitng, 12th edition Pg No 508Explanation:Phenothiazines are classified into three groups: a. Aliphatic derivatives- Chlorpromazine h. Piperedine derivative- Thioradazine c. Piperazine derivative- Trifluoperazine, Perphenazine, fluphenazineAmong the above three, a & b are less potent and having more affinity for alpha 1 receptor and hence can cause more hypotensionPiperazine is pore potent typical and less affinity for alpha I receptor, hence less hypotensionButerophenones are the potent typical antipsychotic (haioperidol) having highest Extrapyramidal effects', 'role': 'assistant'}]