This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunomodulators, Subject name: Pharmacology
[{'content': 'Cyclosporine acts by decreasing the production of: \nSelect and explain. \nA. IL-1, B. IL-2, C. IL-6, D. IL-8', 'role': 'user'}, {'content': "Answer: B \nExplanation: Cyclosporine -It profoundly and selectively inhibits T lymphocyte proliferation, IL-2 and other cytokine production and response of inducer T cells to IL-l, without any effect on suppressor T-cells. Stimulation of T cell receptor produces a cascade of Ca2+ dependent events and protein kinase C (PKC) activation. The Ca2+ ions after binding to calmodulin activate a membrane-associated serine/ threonine phosphatase called calcineurin which dephosphorylates regulatory protein 'nuclear factor of activated T-cell' (NFAT), permitting its intranuclear migration and transcription of cytokine genes leading to the production of IL-2 along with other interleukins, GM-CSF, TNFa, interferon, etc. Cyclosporine enters target cells and binds to cyclophilin, an immunophilin class of protein. The complex then binds to and inactivates calcineurin response of the helper T cell to antigenic stimulation fails. Cyclosporine also enhances expression of an inhibitor of IL-2 which attenuates IL-2 stimulated T -cell proliferation and production of killer lymphocytes. ESSENTIALS of MEDICAL PHARMACOLOGY SIXTH EDITION -KD TRIPATHI Page:851", 'role': 'assistant'}]