This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Central Nervous system, Subject name: Pharmacology
[{'content': 'Which of the following is a nonsedative anxiolytic \nSelect and explain. \nA. Buspirone, B. Hydroxyzine, C. Chlorpromazine, D. Alprazolam', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Buspirone:- It is the first azapirone, a new class of antianxiety drugs. Buspirone * Does not produce significant sedation or cognitive/functional impairment. * Does not interact with BZD receptor or modify GABAergic transmission. * Does not produce tolerance or physical depen dence. * Does not suppress BZD or barbiturate with- drawal syndrome. * Has no muscle relaxant or anticonvulsant activity. Buspirone relieves mild-to-moderate genera lized anxiety, but is ineffective in severe cases. mechanism of anxiolytic action:- It is dependent on its selective paial agonistic action on 5-HT1A receptors. By stimulating presynaptic 5-HT1A autoreceptors, it reduces the activity of dorsal raphe serotonergic neurones. Ref:-kd tripathi; pg num:-466,467', 'role': 'assistant'}]