This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Respiratory System, Subject name: Physiology
[{'content': 'On acclimatizing to new height, our body maintains the body pH by \nSelect and explain. \nA. Retaining HCO3, B. Excretion of HCO3 by kidney, C. Producing more Hb which is a buffer, D. Increasing 2,3-DPG', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ans: d (Increasing 2,3-DPG) Ref: Ganong 22nd ed/ p.686AcclimatizationAn acclimatized person is one who has developed compensatory mechanisms, so that hypoxia causes less adverse effects on the body.Compensatory mechanisms in acclimatization:-*Ventilatorv response:-The initial ventilatory response is small as alkalosis tends to counteract effect of hypoxia. However, ventilation increases over the next 4 days. After 4 days, ventilatory response begins to decline slowly.The respiratory alkalosis produced by hyperventilation shifts O2-Hb dissociation curve to the left, but a concomitant increase in 2,3- DPG tends to decrease the O2 affinity of haemoglobin.*Bloodresponse:-Erythropoetin secretion increases and then falls after 4 days.The increase in RBC begins in 2-3 days (polycythemia)* Compensatory changes in tissue:-Mitochondria increases in number.Myoglobin increases.Cytochrome oxidase content increases.', 'role': 'assistant'}]