This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NSAIDs, Gout and Rheumatoid Ahritis, Subject name: Pharmacology
[{'content': 'Rofecoxib as compared to indomethacin is: \nSelect and explain. \nA. Less likely to cause gastric ulcer and their complications, B. Likely to be more effective in rheumatoid ahritis, C. Not likely to produce renal complications, D. All of the above', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Selective COX-2 inhibitors are less likely to cause GI complications like PUD. However as COX-2 is also present constitutively in the kidney, chances of renal complications are similar. These drugs have similar or less efficacy than non-selective COX inhibitors.', 'role': 'assistant'}]