This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hematology, Subject name: Pharmacology
[{'content': 'Folinic acid is specifically indicated for \nSelect and explain. \nA. Anaemia associated with renal failure, B. Pernicious anaemia, C. Counteracting toxicity of high dose methotrexate, D. Prophylaxis of neural tube defect in the offspring of women receiving anticonvulsant medication', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Methotrexate toxicity:- Folinic acid (Leucovorin, citrovorum factor, 5-formyl-THFA) is an active coenzyme form which does not need to be reduced by DHFRase before it can act. Methotrexate is a DHFRase inhibitor; its toxicity is not counteracted by folic acid, but antagonized by folinic acid. Ref:- kd tripathi; pg num:-611', 'role': 'assistant'}]