This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
[{'content': 'All are true about Koch’s postulates except: \nSelect and explain. \nA. Disease should be susceptible to broad spectrum antibiotics, B. Organism causing lesion can be isolated from lesion, C. Organism can be cultured in media, D. Organism causes similar lesion if inoculated in other person', 'role': 'user'}, {'content': "Answer: A \nExplanation: (Refer: Anantha Narayanan and Paniker’s Textbook of Microbiology, 9th edition, pg no: 4)\nKoch's postulates\nA microorganism to be accepted as the causative agent of an infectious disease has to satisfy the following conditions:\n\nThe bacterium should be constantly associated with the lesions of the disease.\nIt should be possible to isolate the bacterium in pure\n\tculture from the lesions.\nInoculation of such pure culture into suitable laboratory animals should reproduce the lesions of the disease.\nIt should be possible to re-isolate the bacterium in pure culture from the lesions produced in experimental animals.\n\nAn additional criterion added later was that specific antibodies to the bacterium be demonstrable in the serum of patients suffering from the disease.\nPathogenic organisms that do not obey the Koch's postulates\n\nMycobacterium leprae\nBorrelia burgdorferi\nTreponema pallidum\nTropheryma whippelii\nRhinosporidium seeberi\nRickettsia , Chlamydia\nViruses\n\nMolecular form of Koch's postulates\n\nPhenotype of interest should be associated significantly more often with pathogenic members of a genus or pathogenic strains of a species than with non-pathogenic members or strains.\nSpecific inactivation of the gene or genes associated with the suspected virulence trait should lead to a\n\tmeasurable decrease in virulence.\nRestoration of full pathogenicity should accompany replacement of the mutated version of the gene with the wild- type version in the strain of origin.", 'role': 'assistant'}]