This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
[{'content': 'A 30 year old lady presents to the outpatient depament with an Erythematous butterfly rash on her checks. Which of the following antibodies should be assayed initially for her suspected condition - \nSelect and explain. \nA. Anti-Ds-DNA, B. Anti-Ro-Antibody, C. Anti-Centromere-Antibody, D. Anti-mitochondrial-Antibody', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Anti-dsDNA antibodies are a group of anti-nuclear antibodies (ANA) and their target antigen is double stranded DNA. Blood tests such as enzyme-linked immunosorbent assay (ELISA) and immunofluorescence are routinely performed to detect anti-dsDNA antibodies in diagnostic laboratories. They are highly diagnostic of systemic lupus erythematosus (SLE) and are implicated in the pathogenesis of lupus nephritis.', 'role': 'assistant'}]