This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'Defect in folding of the protein result in which of the following clinical disease: \nSelect and explain. \nA. Kuru, B. Migraine, C. Hypothyroidism, D. Myopia', 'role': 'user'}, {'content': 'Answer: A \nExplanation: A i.e. Kuru', 'role': 'assistant'}]