This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
[{'content': 'Which of the following condition does not present with both mullerian and wolffian duct structures? \nSelect and explain. \nA. Antimullerian hormone deficiency, B. FSH receptor mutation, C. Ovotesticular syndrome, D. Mixed gonadal dysgenesis', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Karyotype is 46 XY\nSince Y chromosome is present gonads are testis, i.e. they are males. In this syndrome, in males - Sertoli cells fail to secrete Mullerian inhibiting substance and the Mullerian duct is present.\nSince Leyding cell is also present, they secrete testosterone normally, thus Wolffian duct is also present. So in anti-Mullerian hormone deficiency, both Mullerian and Wolffian ducts are present.\nOvotestis: It is seen in true hermaphroditism. Both ovaries and testis are present. There is the ambiguity of external genitalia. The internal structures depend on the degree of differentiation of the gonads.\nMixed Gonadal dysgenesis Karyotype = 45XO/46XY.\nIn this situation, the gonadal pattern on one side is streak gonad ovary (corresponding to karyotype 45 XO) and a normal testis on the other side (corresponding to karyotype 46 XY)\nMullerian duct and Wolffian duct development correlates with the character of the ipsilateral gonad, i.e.\n\n45 XO / 46 XY\nStreak\nGonads/ovary\n\xa0 \xa0 \xa0 ↓\nFormation of ipsilateral Mullerian duct\nTestis\n\xa0 \xa0 ↓\nFormation of ipsilateral Wolffian duct', 'role': 'assistant'}]