This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immune system, Subject name: Medicine
[{'content': 'In which of the following combinations of auto antibodies are both antibodies used in the diagnosis of the same autoimmune disease? \nSelect and explain. \nA. Anti-SS-A (Ro) and anti-centromere antibodies, B. Anti-smith (Sm) and anti-double-stranded DNA antibodies, C. Anti-ribonucleoprotein and anti-histone antibodies, D. Anti-SS-B (La) antibodies and anti-single -stranded DNA antibodies', 'role': 'user'}, {'content': "Answer: B \nExplanation: Anti-Smith (Sm) and anti-double-stranded DNA antibodies are both used in the diagnosis of systemic lupus erythematosus (SLE). Anti-Sm (Smith) antibodies are less sensitive (30%) than anti-double-stranded DNA (60% to 70%), but are more specific (100%). Regarding the other choices: Anti-SS-A (Ro) antibodies are positive in Sjogren syndrome and anticentromere antibodies are positive in CREST syndrome. Anti-ribonucleoprotein has a high specificity for mixed connective tissue disease. Anti-histone antibodies have a high specificity (> 95%) in drug-induced SLE. Anti-SS-B (La) antibodies have a high specificity (60%-90%) for Sjogren syndrome. Anti-single-stranded DNA antibodies are commonly seen in drug-induced SLE. Anti-mitochondrial antibodies have a high specificity for primary biliary cirrhosis. Anti-microsomal antibodies are seen in Graves disease and Hashimoto's thyroiditis. Ref - Harrison's principles of internal medicine 20e pg 2515, 2516f, 2517t, 2518t, 2522", 'role': 'assistant'}]