This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Urea Cycle and Disorders, Subject name: Biochemistry
[{'content': 'Enzyme deficiency responsible for gout are all except: \nSelect and explain. \nA. PRPP synthase, B. Pseudogout enzyme, C. 5 - phosphoribosyl amido transferase, D. Glucose 6 phosphatase', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Ref: Harpers Illustrated Biochemistry,28th editionExplanation:Hyperuricemia - Uric acid level:Males > 7 mg / dLFemales > 6 mg / dLAccumulation of insoluble monosodium urate crystals in the synovial fluid causes inflammationAcute arthritis.Deposition in cooler areas - TophiRenal lithiasis.PRIMARY GOUT- CausesAbnormality in 5 - phosphoribosyl amido transferase.Abnormality in PRPP synthetase.Deficiency of enzymes of salvage pathway.Glucose-6-phosphatase deficiency.Increased activity of Glutathione reductaseSECONDARY GOUT- CausesIncreased turnover rate of nucleic acids.Leukemias, polycythemia.Treatment of Malignant tumors.Psoriasis.Reduced excretion rate.Renal failure.Thiazide diuretics.Lactic acidosis and Ketoacidosis.', 'role': 'assistant'}]