This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'A factor that is likely to increase the duration of action of a drug D that is partially metabolized by CYP3A4 in the liver is: \nSelect and explain. \nA. Chronic administration of phenobarbital with the drug, B. Chronic administration of cimetidine with the drug, C. Displacement from tissues binding sites by another drug, D. Chronic administration of rifampicin', 'role': 'user'}, {'content': 'Answer: B \nExplanation: - Microsomal enzyme inducers- Rifampicin, Phenobarbital- will increase the activity of enzymes, leading to decreased duration of action of a drug.\n- Microsomal enzyme inhibitor- Cimetidine- will decrease the activity of enzyme resulting in increased duration of action of the drug.\n- A drug displaced from the binding site gets easily metabolized.', 'role': 'assistant'}]