This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Adverse Drug Effect, Subject name: Pharmacology
[{'content': 'Most serious adverse effect of penicillin is:(1994) \nSelect and explain. \nA. Skin rashes, B. Jarish Hexheimer reaction, C. Anaphylaxis, D. Convulsion', 'role': 'user'}, {'content': 'Answer: C \nExplanation: cRef: KDT, 5th ed, p. 656, 657 & 4th ed, p. 704, 705', 'role': 'assistant'}]