This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Social & Preventive Medicine
[{'content': 'Poliomyelitis is diagnosed by: September 2010 March 2013 (a, h) \nSelect and explain. \nA. Clinical presentation, B. Antibody titer measurement in blood, C. Isolation of virus from blood, D. Isolation of virus from stool', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ans. D: Isolation of virus from stool Poliomyelitis diagnosis may be confirmed with a laboratory diagnosis. Viral isolation Poliovirus may be recovered from the stool or pharynx of a person with presumed poliomyelitis. Isolation of virus from the cerebrospinal fluid (CSF) is diagnostic, but is rarely accomplished. If poliovirus is isolated from a person with acute flaccid paralysis, it must be tested fuher, using oligonucleotide mapping (fingerprinting) or genomic sequencing, to determine if the virus is "wild-like" or "vaccine-like." Serology Neutralizing antibodies appear early and may be at high levels by the time the patient is hospitalized and, therefore, a 4-fold rise may not be demonstrated. Cerebrospinal fluid (CSF) The CSF in poliovirus infection usually contains an increased number of white blood cells (10 to 200 cells/mm 3, primarily lymphocytes) and a mildly elevated protein from 40 to 50 mg/100 ml.', 'role': 'assistant'}]