This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Glaucoma, Subject name: Ophthalmology
[{'content': 'Main MOA brimonidine in glaucoma - \nSelect and explain. \nA. Decreased aqueous secretion, B. Increased trabecular outflow, C. Increased uveoscleral outflow, D. Reduce vitreous volume', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Brimonidine (0.2% : 2 times/day). It is a selective alpha-2-adrenergic agonist and lowers IOP by decreasing aqueous production. Because of increased allergic reactions and tachyphylaxis rates it is not considered the drug of first choice in POAG. It is used as second drug of choice and also for combination therapy with other drugs. Ref.AK Khurana 4th edition page no 223', 'role': 'assistant'}]