This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Virology, Subject name: Microbiology
[{'content': 'Nef gene in HIV is for use- \nSelect and explain. \nA. Enhancing the expression of genes, B. Enhancing viral replication, C. Decreasing viral replication, D. Maturation', 'role': 'user'}, {'content': "Answer: C \nExplanation: nef ( negative factor gene) down regulates viral replication. REF:ANANTHANARAYAN AND PANIKER'S TEXTBOOK OF MICROBIOLOGY 9TH EDITION PAGE NO-572", 'role': 'assistant'}]