This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Structure and function of protein, Subject name: Biochemistry
[{'content': "Defect in collagen formation is seen in \nSelect and explain. \nA. Scurvy, B. Hunter's syndrome, C. Marfan's syndrome, D. Osteogenesis imperfecta", 'role': 'user'}, {'content': 'Answer: A \nExplanation: Scurvy is caused due ti deficiecy of ascorbc acid. Ascorbic acid is necessary for the post-transltional hydroxylation of proline and lysine residues. Hyroxyproline and hydrolysine are essential for the formation of crosslinks in the collagen, which gives the tensile strength to the fibers. This process is absolutely necessary for the normal production of suppoing tissues such as osteiod, collagen and intercellular cement substance of capillaries. REFERENCE: DM VASUDEVAN SEVENTH EDITION ; PAGE NO:497', 'role': 'assistant'}]