This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: miscellaneous, Subject name: Biochemistry
[{'content': 'I-cell disease is associated with \nSelect and explain. \nA. Golgi apparatus, B. Lysosomes, C. Peroxisomes, D. Mitochondria', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Mutations in proteins of the plasma membrane, with one affecting lysosomal function (I-cell disease).I-cell disease - Mutations in the gene encoding GlcNAc phosphotransferase, resulting in absence of the Man 6-P signal for lysosomal localization of ceain hydrolases', 'role': 'assistant'}]