This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': 'Which of the following is the most sensitive marker of active Hepatitis B virus replication : \nSelect and explain. \nA. HBV DNA, B. HBV DNA polymerase, C. HBeAg, D. Transaminases', 'role': 'user'}, {'content': "Answer: A \nExplanation: Answer is A (HBV DNA) HBV DNA is the most sensitive marker of active Hepatitis B virus replication `HBV DNA is the most sensitive marker of virus replication. The detection of HBV DNA as the most sensitive marker of virus replication end as such proof of infectivity has replaced the determination of DNA polymerase' -- 'Hepatology' by Kuntz 3rd/121 `The gold standard for confirmation of viral replication is qualitative HBV DNA detection' -- 'Viral Infections & Treatment' by Weigmann (2003)/225 Markers for HBV Replication HBV DNAe > HBV DNA polymerasee > HBe Age", 'role': 'assistant'}]