This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': "Gluten sensitive enteropathy is most strongly associated with which of the following? \nSelect and explain. \nA. HLA DQ2, B. HLA DR4, C. HLA DQ3, D. Blood group 'B'", 'role': 'user'}, {'content': 'Answer: A \nExplanation: 95% of patients with gluten sensitive enteropathy express HLA DQ2 histocompatibility antigen on chromosome 6. In celiac sprue, the fundamental disorder is a sensitivity to gluten. When small intestinal mucosa is exposed to gluten, there is intraepithelial accumulation of cytotoxic T cells and helper T cell in the lamina propria. Cytokines released by the T cells in turn damage intestinal enterocytes.Ref: Robbins Pathologic Basis of Disease, 6th Edition, Page 813.', 'role': 'assistant'}]