This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Radiology
[{'content': 'Earliest radiological change to appear in case of acute osteomyelitis is \nSelect and explain. \nA. Periosteal reaction, B. Loss of plane between soft tissue and muscle, C. Sequestrum formation, D. Bony sclerosis', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Ans. Loss of plane between soft tissue and muscle', 'role': 'assistant'}]