This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Disorders of Adrenal Gland, Subject name: Medicine
[{'content': 'Causes of diffuse hyperpigmentation include all of the following except? \nSelect and explain. \nA. Busulfan administration, B. Nelsons syndrome, C. Addison disease, D. Hermansky-Pudlak Syndrome', 'role': 'user'}, {'content': "Answer: D \nExplanation: Busulfan administration Busulfan, cyclophosphamide, 5-fluorouracil, and inorganic arsenic induce pigment production and cause diffuse hyperpigmentation Nelson's syndrome Increased ACTH (Which has paial MSH activity) due to bilateral adrenalectomy Addison's disease Increased ACTH (Which has paial MSH activity) due to destruction of adrenal coex and low coisol Hermanksy- Pudlak syndrome Autosomal recessive disorder which results in oculo-cutaneous albinism (decreased pigmentation), and bleeding problems due to a platelet abnormality (platelet storage pool defect)", 'role': 'assistant'}]