This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunity, Subject name: Pathology
[{'content': 'Changes in which amyloid structure makes it insoluble? \nSelect and explain. \nA. Primary, B. Secondary, C. Tertiary, D. Quaternary', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e., Secondary * Amyloid is a protein that has an alteration in its secondary structure which imparts it a particular insoluble form, called the beta-pleated sheet conformation.* Amyloid material is composed of two components -i) Major component (95%) - Fibril amyloid protein.ii) Minor components (5%) - P-component, proteoglycans and sulfated glycosaminoglycans.* Fibril amyloid protein is responsible for tissue dysfunction due to pressure effect, while Pcomponent contributes to amyloid deposition by stabilizing fibril amyloid protein and decreasing their clearance.", 'role': 'assistant'}]