This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'A 4 year old female child complains of weakness and pain in joints. Her parents are known case of sickle cell trait. Hb electrophoresis reveal HbS pattern. This disease occurs because of which base alteration? \nSelect and explain. \nA. CTC → CAC in DNA, B. GAG → GUG  in DNA, C. CTC → CAC  in  RNA, D. GAG → CAC  in RNA', 'role': 'user'}, {'content': 'Answer: A \nExplanation: The\xa0occurrence\xa0of\xa0the\xa0disease sickle-cell anemia\xa0due\xa0to\xa0a\xa0single\xa0base\xa0alteration (CTC +\xa0CAC\xa0in\xa0DNA,\xa0and\xa0GAG +\xa0GUG\xa0in RNA) is a classical example of the seriousness\xa0of mutations.\nSatyanarayana- Biochemistry, 3rd edition, pg-549', 'role': 'assistant'}]