This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
[{'content': 'Which of the following drugs require dose adjustment in renal failure? \nSelect and explain. \nA. Cefoperazone, B. Doxycycline, C. Streptomycin, D. Rifampicin', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Reduce dose even in mild failure :Aminoglycosides, Amphotericin B ,Ethambutol ,Vancomycin Flucytosine Reduce dose only in moderate-severe failure Metronidazole, Carbenicillin ,Cotrimoxazole Aztreonam, Meropenem ,Fluoroquinolones Clarithromycin ,Imipenem Drugs to be avoided: Cephalothin ,Talampicillin ,Nalidixic acid, Tetracyclines ,Nitrofurantoin (except doxycycline) ESSENTIALS OF MEDICAL PHARMACOLOGY page no.695', 'role': 'assistant'}]