This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'Treatment of multiple carboxylase deficiency – \nSelect and explain. \nA. Biotin, B. Pyridoxine, C. Thiamine, D. Folic acid', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Pathogenesis of multiple carboxylase deficiency \n\nDeficiency of either holocarboxylase synthase or biotinidase impaires biotin metabolism.\nBiotin is a cofactor for various carboxylases in the body -\nImpaired metabolism of biotin results in multiple carboxylase deficiency.\nSo, for the treatment of multiple carboxylase deficiency, biotin should be given.', 'role': 'assistant'}]