This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'Thiamine is essential for \nSelect and explain. \nA. Isocitrate dehydrogenase, B. Succinate dehydrogenase, C. Pyruvate dehydrogenase, D. Acetyl CoA synthetase', 'role': 'user'}, {'content': 'Answer: C \nExplanation: The\xa0 enzyme\xa0 pyruvate\xa0 dehydrogenase catalyses\xa0 (oxidative\xa0 decarboxylation)\xa0 the irreversible conversion of\xa0 pyruvate to\xa0 acetyl CoA. This reaction is dependent on thiamine pyrophosphate.', 'role': 'assistant'}]