This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Tryptophan metabolism detail, Subject name: Biochemistry
[{'content': 'Tryptophan loading test is done to detect deficiency of: \nSelect and explain. \nA. TPP, B. PLP, C. Biotin, D. Folate', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Tryptophan loading test detects xanthurenic acid in urine which indicates deficiency of Vitamin B6 i.e. PLP (Pyridoxal phosphate). In the absence of Vitamin B6 the excess of 3-OH-Kynurenine is conveed to Xanthurenic acid after given a load of tryptophan (see Fig below) Figure: Tryptophan catabolism pathway Note:- Histidine load test detects FIGLU (Form-Imino Glutamate) in urine which indicates deficiency of Vitamin B9 Deficiency Common metabolite Specific metabolite Vitamin B6 Homocysteine Xanthurenic acid Vitamin B9 Homocysteine FIGLU Vitamin B12 Homocysteine L-methyl malonic acid', 'role': 'assistant'}]