This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of nucleic acids, Subject name: Biochemistry
[{'content': 'DNA supercoiling is done by \nSelect and explain. \nA. DNA polymerase I, B. DNA polymerase II, C. DNA polymerase III, D. DNA topoisomerase', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Enzymes that catalyze topologic changes of DNA are called topoisomerases. Topoisomerases can relax or inse supercoils, using ATP as an energy source. DNA gyrase is a type of topoisomerase Harper30e pg: 362', 'role': 'assistant'}]