This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
[{'content': 'Fluoroquinolone having longest half-life is: \nSelect and explain. \nA. Levofloxacin, B. Lomefloxacin, C. Ciprofloxacin, D. Moxifloxacin', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Moxifloxacin :It is a long-acting 2nd generation FQ having high activity against Str. pneumoniae, other gram-positive bacteria including Beta-lactam/ macrolide resistant ones and some anaerobes. It is the most potent FQ against M. tuberculosis. Bacterial topoisomerase IV is the major target of action. Moxifloxacin is primarily used for pneumonias, bronchitis, sinusitis, otitis media, in which efficacy is comparable to Betalactam.antibiotics. However, it is not good for urinary tract infections. Side effects are similar to other FQs. It should not be given to patients predisposed to seizures and to those receiving proarrhythmic drugs, because it can prolong Q-Tc interval. Phototoxicity occurs only rarely. ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SIXTH EDITION PAGE NO:693', 'role': 'assistant'}]