This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General Pharmacology, Subject name: Pharmacology
[{'content': 'Which of the following is not necessary to be mentioned on drug advertisement literature? \nSelect and explain. \nA. Expiry date of the drug, B. References of the information, C. Rare but life-threatening adverse effects, D. Common but insignificant adverse effects', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. (A) Expiry date of the drug(Ref: WHO criteria for drug advertisement, Practical Manual of Pharmacology by Dinesh Badyal 1st/e p211-212)According to WHO criteria and OPPI (Organization o Pharmaceutical Producers of India) code of Pharmaceutical practices 2012, the printed drug promotional literature (DPL) must containName of the drug: Brand name should be available with the active ingredient (generic name). The ratio of size of brand name to generic name should not be more than 3:1Indications: Approved therapeutic indications must be present on the DPL.Dosage: Content of active ingredient(s) per dosage form and whole regiment should be written on the DPLPrecautions and warningsContraindicationsAdverse effects: All serious adverse effects and common non-serious adverse effects should be mentioned on the DPLMajor interactionsPrice: Price of the drug as well as whole regimen should be present on DPL.Information of manufacturer: The name and address of the pharmaceutical company or its agent responsible for marketing the product must be present on DPLReference to scientific literature: Appropriate references should be available regarding the claims made by the DPL.', 'role': 'assistant'}]