This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Gastrointestinal tract, Subject name: Pharmacology
[{'content': 'Regarding aprepitant all are true execpt: \nSelect and explain. \nA. Agonist at NK1 receptors, B. Crosses blood brain barrier, C. Ameliorate nausea and vomiting induced by chemotherapy, D. Metabolized by CYP450 enzymes', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Aprepitant is a highly selective NK1 receptor antagonist orally active and enter the brain. It is used in treating and preventing chemotherapy induced emesis. It is metabolized by CYP3A4 enzymes and can also inhibit the metabolism of drugs metabolized by this enzyme e.g.warfarin.(Katzung 11/e p 1086,Goodman and Gilman 11/ep650)', 'role': 'assistant'}]