This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Antimicrobial Drugs, Subject name: Pharmacology
[{'content': 'Most impoant mechanism of development of resistance to drugs in tuberculosis is \nSelect and explain. \nA. Transduction, B. Conjugation, C. Transformation, D. Mutation', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Most impoant mechanism of development of resistance to anti-tubercular drugs is mutation. DRUG RESISTANCE MUTATION IN GENE Rifampicin rpoB Isoniazid katG and inhA Ethambutol embB Pyrazinamide pncA', 'role': 'assistant'}]