This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anatomy of Skin, Subject name: Skin
[{'content': 'All of the following are true regarding Fordyce spots except ____: \nSelect and explain. \nA. Ectopic sebaceous glands, B. They are asymptomatic, C. Associated with hair follicles, D. Occur commonly on upper lip', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ans. C. Associated with hair folliclesFordyce spots are not associated with hair folliclesFordyce SpotsFordyce spots/Fordyce granules:* The Fordyce spots are heterotopic sebaceous glands wherein the duct is connected directly to the overlying skin or mucosal surface unlike other sebum glands which open into the follicle.* They are called ectopic/free-lying sebaceous glands.* They occur commonly on the vermilion border of upper lip(m/c), buccal mucosa, skin over penile shaft and areolar of the breast.* They are commonly multiple and appear asymmetrical discrete yellow papules.* Fordyce spots on penis are called Tyson glands.* They are asymptomatic.* Treatment ladder- First line: Reassurance- Second line# Local destruction with superficial cautery or electrodessication# Topical trichloroacetic acidFordyce spots on the vermilion border of both lips in A, upper lip in B, and buccal mucosa in C.', 'role': 'assistant'}]