This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of lipid, Subject name: Biochemistry
[{'content': 'A patient with abetalipoproteinemia frequently manifests with delated blood clotting. This is due to inability to \nSelect and explain. \nA. Produce VLDL, B. Synthesize fatty acids, C. Produce chylomicrons, D. Synthesize clotting factors', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Type-III: Familial Dys-Beta Lipoproteinaemia:Synonyms: Broad Beta disease, \'Remnant\' removal diseaseThe disease is characterised by:Increase in b-lipoproteins (LDL |)Increase in Pre-b-lipoproteins (VLDL |);Actually rise is in IDL (VLDL remnant). This appears as broad b-band ("floating" b-band)-b- VLDL on electrophoresis. Also, there is hypercholesterolemia and hyperiglyceridemia.Inheritance: Autosomal dominant.Metabolic defects:Increased concentration of apo-E |.Increased synthesis of apo-B |.Conversion of normal VLDL to b-VLDL (IDL) and its degradation without conversion to LDL. Defect is in "Remnant" metabolism.Clinical feature: Presents with Xanthomastuberous and palmar Xanthomas. Premature cardiovascular diseases and atherosclerosis common. Also prone to develop peripheral vascular diseases.Treatment:By weight reductionLow carbohydrate diets, containing unsaturated fats and little cholesterolRef: Textbook of Medical Biochemistry, 8th Edition, Dr (Brig) MN Chatterjea, Rana Shinde, page no: 452,453', 'role': 'assistant'}]