This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Diagnosis in Obstetrics, Subject name: Gynaecology & Obstetrics
[{'content': 'As an isolated finding, highest risk of Downs Syndrome is seen with? \nSelect and explain. \nA. Increased Nuchal fold thickness, B. Shortened femur, C. Absence of nasal bone, D. Echogenic bowel', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. A. Increased Nuchal fold thicknessUltrasonographic soft markers are associated with Downs Syndrome, especially when they occur in combination.However, as an isolated finding, increased nuchal skin fold thickness carries the highest association. The other soft markers are:a. Hypoplastic nasal boneb. Echogenic cardiac focusc. Echogenic boweld. Shortened femure. Shortened humerusf. Single umbilical arteryg. Mild pyelectasis', 'role': 'assistant'}]