This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Psychiatry
[{'content': 'Disruption or disorganization of biological rhythm is observed in - \nSelect and explain. \nA. Schizophrenia, B. Anxiety, C. Depression, D. Mania', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Diurnal variations symptom severity and alterations in circadian rhythmicity of number of neurochemical and neurohumoral factors suggest that biologic differences may be secondary to a primary defect in regulation of biologic rhythms.', 'role': 'assistant'}]