This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'True about Dyskeratosis congenita -a)  Pancytopeniab)  Nail dystrophyc)  Hyperkeratosisd)  X linkede)  Leukoplakia \nSelect and explain. \nA. abcd, B. bcde, C. acde, D. abde', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Dyskeratosis congenita\n\nIt is characterised by mucous membrane leukoplakia, dystrophic nails, reticular hyperpigmentation and the development of aplastic anemia during chidhood.\nThe X-linked variety is due to mutations in the DKC1 (dyskeratin) gene; the more unusual autosomal dominant type is due to the muatation in hTERC, which encodes an RNA template, and hTERT, which encodes the catalytic reverse transcriptase, telomerase; these gene products cooperate in a repair complex to maintain telomere length.\nClinical features associated with dyskeratosis congenita are\xa0:-\nSkin pigmentary abnormalities\xa0\xa0\xa0\xa0\xa0\xa0\nNail dystrophy\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\nLeukoplakia\nEpiphora\xa0\xa0\nCognitive/develpomemt delay\nPulmonay disease\nDental carries/tooth loss\xa0\xa0\xa0\xa0\xa0\nEsophageal stricture\nHair loss/grey hair / sparse eyelashes\xa0\nHyperhydrosis\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\nIntrauterine growth retardation', 'role': 'assistant'}]