This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Phenylalanine and Tyrosine metabolism Detail, Subject name: Biochemistry
[{'content': 'Phenylalanine is degraded into \nSelect and explain. \nA. Fumarate and succinate, B. Fumarate and acetoacetate, C. Fumarate and Malate, D. Fumarate and pyruvate', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Phenylalanine is first conveed to tyrosine (For Subsequent metabolism of phenylalanine and tyrosine See att. Treasure. Hereditary tyrosinemia type I (Hepatorenal tyrosinemia) is due to deficiency of the enzyme fumaryl acetoacetate hydrolase (fumarylacetoacetase). Remember the enzyme deficiency - fumarylacetoacetase. That will help you to remember the end products - Fumarate and acetoacetate. Phenylalanine & tyrosine are both glucogenic and ketogenic. Fumarate is glucogenic while acetoacetate is ketogenic.', 'role': 'assistant'}]