This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Which of the following statement(s) is/are about reticulocyte? \nSelect and explain. \nA. Smaller than RBC, B. ↑in hemolytic anemia, C. Staining is done by Romanowsky stain, D. Contain nucleus', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Reticulocytes \n\nReticulocytes are immature red blood cells. Reticulocytes (slightly larger than RBCs) typically compose about 1% of the red cells.\nReticulocytes develop and mature in the bone marrow and then circulate for about a day in the blood before developing into mature red blood cells.\nLike red blood cells, reticulocytes do not have a nucleus.\nReticulocytes are so named because of a reticular (mesh-like) network of ribosomal RNA that becomes visible under a microscope with supravital stains such as methylene blue and Brillient cresyl blue.\nReticulocytes appear slightly bluer than other red cells when looked at with the normal Romanowsky stain.\nWhen there is an increased production of red blood cells to overcome chronic or severe loss of mature RBCs, such as in hemolytic anemia, people often have markedly high number and percentage of reticulocests (reticulocytosis).\nDecreased numbers of reticulocytes is seen in chemotherapy, aplastic anemia, iron deficiency anemia, Vit B folic acid deficiency, pernicious anemia, bone marrow malignancies, anemia of chronic disease.\n\n\nNote :\n\nUsually supravital stains (methylene blue and Brilliant cresyl blue) are used for reticulocytes.\nRomanowsky stain is not used specifically for reticulocytes.', 'role': 'assistant'}]