This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: miscellaneous, Subject name: Pathology
[{'content': "In which layer of cornea, copper is deposited to form Kayser-Fleischer ring in Wilsons disease? \nSelect and explain. \nA. Bowman's layer, B. Corneal stroma, C. Descemet's membrane, D. Corneal endothelium", 'role': 'user'}, {'content': 'Answer: C \nExplanation: Nearly all patients with neurologic involvement in Wilson disease develop eye lesions called Kayser-Fleischer rings, green to brown depositsof copper in Descemet membrane in the limbus of the cornea.Wilson disease is an autosomal recessive disorder caused by mutation of the ATP7B gene, resulting in impaired copper excretion into bile and a failure to incorporate copper into ceruloplasmin. This disorder is marked by the accumulation of toxic levels of copper in many tissues and organs, principally the liver, brain, and eye.Ref: Robbins Pathology; 9th edition; Page no: 849', 'role': 'assistant'}]