This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Treatment and Survival (Carcinoma Ovary), Subject name: Gynaecology & Obstetrics
[{'content': 'Chemotherapy for choriocarcinoma. DOC is- \nSelect and explain. \nA. Methotrexate, B. Cyclophosphamide, C. Cisplatin, D. Doxorubicin', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Methotrexate Chemotherapy in molar pregnancyIndicationso If the hCG level fails to become normal in stipulated time (10-12 weeks) or re-elevates after 4-8 weeks.o Rising ji-hCG level, once it reached normal,o Post evacuation haemorrhageo Where followr up facilities are not adequateo Evidence of metastasis irrespective of hCG levelso Risk of malignancy is highChemotherapyo Methotrexate 1 mg'kgday is given iv or im on day 1,3,5 & 7 with folinic acid . 1 mg/kg on days 2,4,6 & 8. It is to be repeated every 7 days. A total of 3 courses are given,o Alternatively, intravenous actinomycin-D 12 mcg/kg/day is given for 5 days. It is less toxic.", 'role': 'assistant'}]