This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': "Lowe's syndrome is characterised by the following except – \nSelect and explain. \nA. Hypophosphatamic rickets, B. Undescended testes, C. Defect in the CNS and eyes, D. Aminoaciduria", 'role': 'user'}, {'content': "Answer: B \nExplanation: Lowe's syndrome\n\nIt is also known as an oculocerebrorenal syndrome of Lowe.\nIt is an X-linked disorder.\nIt is characterized by :\n\ni) Congenital cataract\nii) Mental retardation\niii) Fanconi syndrome → Aminoaciduria\n\nThe disease is caused by a mutation in the OCRL1 gene, which encodes the phosphatidylinosital polyphosphate 5-phasphatasq.\n\nClinical features\n\nProgressive growth failure o Hypotonia \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0\xa0\nBlindness\xa0\xa0\xa0\xa0\nFanconi syndrome \xa0\xa0\xa0\nRenal inefficiency \xa0\xa0\xa0\xa0\xa0\nBehavioural problems\xa0\xa0\xa0\nSignificant proteinuria", 'role': 'assistant'}]