This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Platelet, Subject name: Pathology
[{'content': 'Glanzmann disease is characterised by which of the following? \nSelect and explain. \nA. Congenital defect of RBCs, B. Defect of neutrophils, C. Congenital defect of platelets, D. Clotting factor deficiency', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Glanzmann disease - AR inheritance - Inherited defect in glycoprotein GpIIb-IIIa The GpIIb/IIIa receptors on activated platelets form bridging crosslinks with fibrinogen, leading to platelet aggregation. - Functional platelet defect as they are less able to adhere to each other and to damaged blood vessel. S/S- purpura, epistaxis, gingival hemorrhage, and menorrhagia are nearly constant features; gastrointestinal bleeding and hematuria are less common. - Increased bleeding with Normal platelet count - ADP and collagen aggreagtion tests are done for aggregation defect.', 'role': 'assistant'}]