This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolic Bone Disease, Subject name: Orthopaedics
[{'content': "Mutations in type I collagen fibres results is: \nSelect and explain. \nA. Marfan's syndrome, B. Osteosclerosis, C. Osteopetrosis, D. Osteogenesis imperfecta", 'role': 'user'}, {'content': 'Answer: D \nExplanation: (Osteogenesis imperfecta) (268-M) (153-Apley\'s 8th)* Osteogenesis imperfecta (Brittle bones) is one of the commonest of the genetic disorders of bone.* Abnormal synthesis and structural defects of type I collagen results in abnormalities of bones teeth, ligaments, sclerae and skin.Clinical features are1. Osteopenia2. Liability to fracture3. Laxity of ligaments4. Blue colouration of the sclerae5. Dentinogenesis imperfecta ("Grumbling teeth")', 'role': 'assistant'}]