This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
[{'content': 'Causes for reduced bioavailability include \nSelect and explain. \nA. high first pass metabolism, B. increased absorption, C. high lipid solubility, D. non ionization', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ref-KDT 7/e p18 the causes of low availability are reduced absorption highfirst pass metabolism', 'role': 'assistant'}]