This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Surgery
[{'content': 'A new born presented with bloated abdomen sholy after bih with passing of less meconium. A full thickness biopsy rectal biopsy finding is most likely to be present. \nSelect and explain. \nA. Fibrosis of submucosa, B. Hyalinisation of the muscular coat, C. Thickened Muscularis propria, D. Lack of ganglion cells', 'role': 'user'}, {'content': "Answer: D \nExplanation: .hirschsprung disease is a congenital, familial condition, occurring in newborn due to the absence of ganglion cells-- Auerbach's and Meissner's plexus in anorectum, which may extend proximally either a pa or full length of the colon. * It always involves the anus, internal sphincter and rectum (paly or entirely). * There is narrow, spasmodic, non relaxing pathological segment. * Transitional zone proximal to it contains only few ganglion cells with formation of cone. ref:SRB&;s manual of surgery,ed 3,pg no 818", 'role': 'assistant'}]