This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hodgkins Lymphoma, Subject name: Pathology
[{'content': "Owl' eye nucleus is seen in which type of lymphoma? \nSelect and explain. \nA. Non- Hodgkin's lymphoma, B. Hodgkin's lymphoma, C. Burkitt's lymphoma, D. Cutaneous T-cell lymphoma", 'role': 'user'}, {'content': 'Answer: B \nExplanation: Ans is \'b\' i.e., Hodgkin\'s lymphoma o "Owl\'s eye" appearance of entire nucleus is seen in Reed-Sternberg cells.o Reed-Sternberg cells are giant cells with multinucleated or have a bilobed nucleus with prominent eosinophilic inclusion-like nucleoli (thus resembling an "owl\'s eye"appearance). These are positive for CD 15 and CD 30, and also PAX-5 (B-cell transcription factor).o Hodgkin\'s disease is characterized by presence of Reed-sternberg cells (Classical Reed-sternberg cells) and its variants.o They can also be found in reactive lymphadenopathy (such as infectious mononucleosis immunoblasts which are RS like in appearance], carbamazepine associated lymphadenopathy) and very rarely in other types of non-Hodgkin lymphofnas. Anaplastic large cell lymphoma may also show RS like cells.', 'role': 'assistant'}]