This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Biochemistry
[{'content': 'Which of the following does not occur in lysosomal storage disorders: \nSelect and explain. \nA. Increased number and size of lysosomes, B. Accumulation of the polyubiquinated proteins, C. No neurological deficit, D. Apoptosis defects', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Lysosomal storage disorders : Inborn diseases due to lack or inactivity of lysosomal hydrolases, transpoers or integral membrane proteins. Have severe neurological abnormalities. Large vacuoles and ubiquitinated aggregates, promoting degradation and induction of lysosome biogenesis. Defects in apoptosis. Substrate accumulation in lysosomes increase the size of lysosomes.', 'role': 'assistant'}]