This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pharmacokinetics, Subject name: Pharmacology
[{'content': 'True about first order kinetics is: \nSelect and explain. \nA. A constant amount is eliminated in unit time, B. The half-life increases with an increase in dose, C. The rate of elimination is constant, D. The rate of elimination is proportional to the plasma concentration', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ans. d. The rate of elimination is proportional to the plasma concentration (Ref: Katzung 12/e p43-44: KDT 7/e p30-31, 6/e p31-32)Rate of elimination is proportional to plasma concentrationQ first order kinetics (Linear kinetics).First Order Kinetics (Linear kinetics)Zero Order Kinetics (Non linear Kinetics)* Constant fraction of drug is eliminated per unit of timeQ.* Rate of elimination is proportional to plasma concentrationQ.* Clearance remains constantQ.* Half-life remains constantQ.* Most of the drugs follow first order kineticsQ.* Constant amount of the drug is eliminated per unit timeQ.* Rate of elimination is independentQ of plasma concentration.* Clearance is more at low concentrations and less at high concentrationsQ.* Half-life is less at low concentrations and more at high concentrationsQ.* Very few drugs follow pure zero order kinetics e g. alcoholQ* Any drug at high concentration (when metabolic or elimination pathway is saturated) may show zero order kineticsQ.', 'role': 'assistant'}]