This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
[{'content': 'A farmer present with multiple discharging sinuses in the leg not responding to antibiotics. Most likely diagnosis is: \nSelect and explain. \nA. Madurella, B. Actinomycetoma, C. Nocardia, D. Sporothrix', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. (a) Madurella Actinomycetoma, usually responds to antibiotics. Treatment of Mycetonra Actinomycetoma Eumycetoma Prolonged combination chemotherapy, e.g. with streptomycin and either dapsone or cotrimoxazole, cotrimoxazole + amikacin Rarely responds to chemotherapy, some cases caused by Madurella mycetomatic respond to ketoconazole itraconazole, posaconazole', 'role': 'assistant'}]