This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
[{'content': 'The enzyme deficient in Lesch Nyhan syndrome is: \nSelect and explain. \nA. Adenosine Deaminase, B. PRPP synthetase, C. HGPRTase, D. Xanthine oxidase', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ref. Guyton. 13th edition. Page. 879\nLesch-Nyhan syndrome results from a defect in HGPRT, an enzyme involved in the purine salvage pathway.\n\nHGPRT catalyzes the conversion of the free base (hypoxanthine of guanine) to a nucleotide (IMP or GMP).\nHGPRT is not required for de novo purine synthesis, or urate synthesis, or for either the de novo or salvage pathways of pyrimidine metabolism. \u2028\n\nFeatures\n\nSpastic cerebral palsy\u2028\n\n\nSelf-mutilation (hands, lips)\u2028\nHyperuricemia and gout\nEarly death\n\xa0X-linked (recessive)', 'role': 'assistant'}]