This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Biochemistry
[{'content': 'Asians & native americans may flush & feel ill after drinking small amount of ethanol. This reaction is due to genetic variation in which enzyme: \nSelect and explain. \nA. Alcohol dehydrogenase, B. Aldehyde dehydrogenase, C. Isocitrate dehydrogenase, D. Alpha-keto glutarate dehydrogenase', 'role': 'user'}, {'content': 'Answer: B \nExplanation: * Genetic variation occurs in enzyme aldehyde dehydrogenase, specially in people of China, Korea & native America, known as Asian flush syndrome. Increased acetaldehyde causes:- Nausea Vomiting Flushing Sweating Tachycardia & hyperventilation ADDITIONAL READING ON ALCOHOL DEHYDROGENASE (ADH): There are many isoenzymes Most abundant - ADH-1A Present in cytoplasm of liver and adrenal glands Has NAD containing domain known as Rossman fold', 'role': 'assistant'}]