This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Depolarising Neuromuscular Blocking Agents, Subject name: Anaesthesia
[{'content': 'Malignant hyperthermia is caused by: \nSelect and explain. \nA. Ryanodine receptor, B. Nicotinic receptor, C. Muscarinic receptor, D. NMDA receptor', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. (a) Ryanodine receptor* Malignant hyperthermia is a condition that is usually triggered by exposure to certain drugs used for general anesthesia, specifically the volatile anesthetic agents and the neuromuscular blocking agent succinylcholine.* Succinylcholine is depolarizing / non competitive M.R. with shortest duration of action (3-5 min) due to rapid hydrolysis by pseudo cholinesterase.* It causes dual/biphasic block. It causes hyperkalemia, increased intraocular & intragastric pressure and temperature which leads to malignant Hyperthermia.* Susceptibility to MH is often inherited as an autosomal dominant disorder, for which there are at least 6 genetic loci of interest, most prominently the Ryanodine receptor gene (RYR1).* DOC for malignant hyperthermia: Dantrolene', 'role': 'assistant'}]