This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NEET Jan 2020, Subject name: Biochemistry
[{'content': 'Enzyme activated by decrease in Insulin: glucagon ratio: \nSelect and explain. \nA. Glucokinase, B. Hexokinase, C. PFK, D. Glucose 6 phosphatase', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Low Insulin: Glucagon ratio means=Catabolicstate (Aslow insulinmeansFasting stateor catabolic state).Insulinis released in Fed state. So, in fasting stateglucose-6-phosphatasewill be active as this enzyme is involved ingluconeogenesis,which occurs duringfasting. OTHER OPTIONS OPTION A: Glucokinase phosphorylates glucose in liver and pancreas, active in fed state and is induced by insulin. OPTION B: Hexokinase also phosphorylates glucose and is present in all cells of the body. It is active in any situation in body as it is a general enzyme to phosphorylate glucose OPTION C: Phospho fructokinase is involved in glycolysis. PFK-1 is active in any situation and PFK-2 is active only in fed state.', 'role': 'assistant'}]