This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Misc., Subject name: Pathology
[{'content': 'Mitochondrial DNA linked disease is \nSelect and explain. \nA. More common in males, B. Transmitted by females, C. Variable penetrance in families, D. Autosomal inheritance', 'role': 'user'}, {'content': 'Answer: B \nExplanation: (B) Transmitted by females# mtDNA inheritance is that it is transmitted strictly through the maternal line.> Low levels of paternal transmission of mtDNA have been observed in crosses between mouse species, but not within species41, although further studies showed that this paternal mtDNA was not transmitted to the subsequent generation.> Cytochrome c oxidase deficiency (mitochondrial DNA mutations), Kearns-Sayre syndrome (single, large deletion of mitochondrial DNA), Leber hereditary optic neuropathy (Mutations in four mitochondrial genes, MT-ND1, MT-ND4, MT-ND4L, and MT-ND6), Leigh syndrome (most commonly mutated mitochondrial gene in Leigh syndrome, MT-ATP6) are some of the examples for moitochondrial diseases.', 'role': 'assistant'}]