This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Microbiology
[{'content': 'The first gene to be knocked out in the carcinogenesis of the endometrium is \nSelect and explain. \nA. PI3KCA, B. PTEN, C. KRAS, D. p53', 'role': 'user'}, {'content': 'Answer: B \nExplanation: The primary gene involved in the transformation of a normal or a hyperplastic endometrium to a neoplastic endometrium is the loss of PTEN gene function.', 'role': 'assistant'}]