This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Anti-tubercular drug not given in liver disease is ? \nSelect and explain. \nA. Isoniazid, B. Ethambutol, C. Pyrazinamide, D. Rifampicin', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ans. is \'c\' i.e., Pyrizinamide o Among the given options, only ethambutol is safe in liver disease. Other three drugs cause hepatotoxicity and should be avoided. o However, if the question is repeated as such, best answer is pyrazinamide because of following statement of Harrison-"In case of presence of hepatic risk factors or if during treatment hepatitis develops in a patient, one might rechallange the patient with rifampicin and isoniazid but pyrizinamide is never given".', 'role': 'assistant'}]