This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Nutritional anemia, Subject name: Pediatrics
[{'content': 'Children with Thalassemia and Iron overload are at an increased risk for infection with? \nSelect and explain. \nA. Yersinia Enterocolitica, B. Campylobacter jejuni, C. Escherichia coli, D. Vibrio cholera', 'role': 'user'}, {'content': 'Answer: A \nExplanation: - Iron therapy may increase the virulence of malaria and ceain, gram-negative bacteria, paicularly in developing countries. - Iron overload is associated with Yersinia infection. EXTRA EDGE: - Iron overload is treated by iron chelation therapy - IRON CHELATION THERAPY: Usually staed when serum ferritin > 1000 ng/ml Deferoxamine - Parenterally (IV or SC) - Effective in reveing hepatic & cardiac iron deposition. Deferiprone - 1st oral chelator. - Adverse effects - Agranulocytosis, GI side effects, ahritis Deferasirox - Oral drug, Effective in decreasing cardiac iron burden & lowering serum ferritin.', 'role': 'assistant'}]