This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Urinary tract, Subject name: Pediatrics
[{'content': 'In a child, non-functioning kidney is Best dignosed by \nSelect and explain. \nA. Ultrasonography, B. IVU, C. DTPA renogram, D. Creatinine clearance', 'role': 'user'}, {'content': 'Answer: C \nExplanation: DTPA RENOGRAM : Inulin clearance remains the gold standard to measure GFR, but it is expensive, time consuming, an requires a steady-state plasma concentration and accurate and timed urine collection . 99&;Tc-DTPA is recommended agent is for GFR measurement. 5- 10% plasma protein binding, so it tends to underestimate the GFR(insignificant) Peak renal activity after 3 -- 4 min. 90 % filtered within 4 hours. The extraction fraction of 99Tc-DTPA is approximately 20 per cent; for this reason, not useful for imaging , in patients with impaired renal function. In such cases, agents with higher extraction efficiencies such as 99Tc-MAG3 more appropriate. Reference: GHAI Essential pediatrics, 8th edition', 'role': 'assistant'}]