This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunomodulator, Subject name: Pharmacology
[{'content': 'Which of the following drugs act by inhibiting granulocyte migration? \nSelect and explain. \nA. Colchicine, B. Montelukast, C. Cromoglycate, D. Allopurinol', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans (A) Colchicine(Ref: Goodman and Gilman 13th/702-703)Colchicine is more effective and faster acting than NSAIDs but is used rarely due to its high toxicity.It acts by inhibiting granulocyte migration into the in- flamed joint.It causes metaphase arrest (other drugs causing meta- phase arrest are vinca alkaloids, ixabepilone and taxanes).Most common and dose limiting toxicity is diarrhea.It can also cause kidney damage, myopathy and bone marrow depression.', 'role': 'assistant'}]