This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autacoids, Subject name: Pharmacology
[{'content': 'Antihistaminic not much preferable in motion sickness among the following is: \nSelect and explain. \nA. Cetirizine, B. Meclizine, C. Diphenhydramine, D. Fexofenadine', 'role': 'user'}, {'content': 'Answer: D \nExplanation: 1st generation drugs better treat motion sickness than 2nd gen drugs due to high sedating nature Fexofenadine is a 2nd gen. antihistaminic Promethazine, diphenhydramine, dimenhydrinate, and meclozine have prophylactic value in milder types of motion sickness; should be taken one hour before staing journey. Promethazine can also be used in morning sickness, drug-induced and postoperative vomiting, radiation sickness.', 'role': 'assistant'}]