This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Integrated QBank, Subject name: Unknown
[{'content': 'A 78-year-old man repos anorexia, fatigue, and generally feeling unwell. On examination he has a large spleen, appears pale, and the rest of the examination is normal. His blood count is abnormal; the WBC is 46000/ml with increased mature granulocytes, hemoglobin 9.0 g/dL, and platelets 450,000/mL. Fuher investigations reveal BCR-ABL transcripts. T315I mutation is also seen. What is the drug of choice for this condition? \nSelect and explain. \nA. Bosutinib, B. Ponatinib, C. Boezomib, D. Chlorambucil', 'role': 'user'}, {'content': 'Answer: B \nExplanation: All Investigation points towards the diagnosis of CML. Management of CML: Tyrosine kinase inhibitors 1st line: Imatinib 2nd line: Dasatinib Nilotinib Bosutinib (DOC for imatinib resistant CML) 3rd line : Ponatinib DOC for T315I mutation DOC when there is failure of >2 TKIs Allogenic stem cell transplantation for patients who have progressed to blast cell crisis stage.', 'role': 'assistant'}]