This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Central Nervous system, Subject name: Pharmacology
[{'content': 'In which of the following disorders,administration of barbiturates is contraindicated? \nSelect and explain. \nA. Anxiety disorders, B. Acute intermittent porphyria, C. Kernicterus, D. Refractory status epilepticus', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Barbiturates induce the rate limiting enzyme amino levulanic acid synthase in porphyrin synthesis. This increased synthesis of prophyrins can precipitate acute attack of AIP Ref: KD Tripathi 8th ed.', 'role': 'assistant'}]