This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Congenital Infections, Subject name: Pediatrics
[{'content': 'Trans-placental spread is least associated with: \nSelect and explain. \nA. Hepatitis B virus, B. Rubella virus, C. Herpes Simplex virus, D. Human Immunodeficiency Virus', 'role': 'user'}, {'content': 'Answer: C \nExplanation: For HSV infection most common mode of transmission is direct contact between mucocutaneous surfaces Source of virus in neonatal infections is typically the mother, & transmission generally occurs during delivery.', 'role': 'assistant'}]