This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti Histaminics, Subject name: Pharmacology
[{'content': 'Which is not a 2nd generation anti-histaminic agent? \nSelect and explain. \nA. Cetirizine, B. Cyclizine, C. Loratidine, D. Fexofenadine', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Ans (B) Cyclizine(Ref: Goodman and Gilman 12th/e p921,922)Antihistaminics may be classified into first generation and second generation compounds on the basis of CNS penetration and anticholinergic properties. First Generation Anti-histaminics can penetrate blood brain barrier and possess additional anticholinergic properties which are lacking in second generation drugs. Cyclizine is a first generation whereas cetirizine, loratadine and fexofenadine are second generation drugs.', 'role': 'assistant'}]