This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous (Gynae), Subject name: Gynaecology & Obstetrics
[{'content': 'True about polycystic ovarian syndrome \nSelect and explain. \nA. Associated with carcinoma endometrium, B. Always associated with obesity, C. Diabetes incipidus, D. Hypo androgenemia', 'role': 'user'}, {'content': "Answer: A \nExplanation: i.e. (Associated with carcinoma endometrium): (369-Shaw's 15th) (467-HI 7th)* The increased conversion of androstenedione to estrogen which occurs to a greater degree in women with lower body obesity may contribute to the increased incidence of uterine cancer in post menopausal women with obesity (467-H17th)* PCOS is most strongly associated with a risk of endometrial carcinoma and may also be associated with an increased risk of ovarian and breast cancer**** Long term sequelae of PCOS- Diabetes mellitus- CVS disorders - MI- Lipidaemia- Hypertension- Endometrial cancer- Breast cancer- Premature ovarian failure following surgery* Autosomal dominant inherited factor** were added as aetiological factor in the development of PCOS. CYP21 gene mutation has been discovered in this connection", 'role': 'assistant'}]