This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology and breast, Subject name: Surgery
[{'content': 'Follicular carcinoma of thyroid is due to mutation of: \nSelect and explain. \nA. RAS, B. HGF, C. RET, D. ABL', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Genes implicated in FCT: p53, PTEN, Ras, PAX8/PPAR1. Oncogenes and Tumour-suppressor Genes implicated in Thyroid Tumorigenesis Gene Function Tumor Oncogenes RET Membrane receptor with tyrosine kinase activity Sporadic and familial MTC, PTC (RET/PTC rearrangements) MET Same Overexpressed in PTC TRK1 Same Activated in some PTC TSH-R Linked to heteromeric G protein Hyperfunctioning adenoma Gs (gsp) Signal transduction molecule (GTP binding) Hyperfunctioning adenoma, follicular adenoma Ras Signal transduction protein Follicular adenoma and carcinoma, PTC PAX8/PPAR1 Oncoprotein Follicualar adenoma, Follicular carcinoma B-Raf (BRAF) Signal transduction PTC, tall cell and poorly differentiated, anaplastic Tumor suppressors p53 Cell cycle regulator, arrests cells in G1, induces apoptosis De-differentiated PTC, FTC, anaplastic cancers p16 Cell cycle regulator, inhibits cyclin dependent kinase Thyroid cancers cell lines PTEN Protein tyrosine phosphatase Follicular adenoma and carcinoma Ref: Sabiston 20th edition Pgno: 901', 'role': 'assistant'}]