This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
[{'content': 'What is the pathogenetic mechanism of HPV in causing cervical carcinoma? \nSelect and explain. \nA. Down regulation of 16INK4 protein, B. Degradation of cyclin D1, C. Genomic instability of E6 and E7, D. Up regulation of BCL2', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Reference : Robbins basic pathology 9th edition : the oncogene city of HPV is related to the expression of two viral oncoproteins,E6 and E7 they bind to Rb and p53,respectively neutralizing their function', 'role': 'assistant'}]