This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
[{'content': 'Next to metastasis, which is the most reliable feature to differentiate a benign from malignant tumour? \nSelect and explain. \nA. Anaplasia, B. Dysplasia, C. Local invasion, D. Metastasis', 'role': 'user'}, {'content': 'Answer: C \nExplanation: .', 'role': 'assistant'}]