This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Burns, Subject name: Surgery
[{'content': "Which among the following is an antibiotic agent that penetrates burn eschar to reach interface with patient's ble tissue ? \nSelect and explain. \nA. Mafenide acetate, B. Neomycin, C. Silver nitrate, D. Silver sulfadiazine", 'role': 'user'}, {'content': "Answer: A \nExplanation: Mafenide acetate Antibiotic agent that penetrates burn eschar to reach interface with patient's ble tissue. Disadvantages- Quite painful on any paial thickness areas, and it is a carbonic anhydrase inhibitor that interferes with renal buffering mechanisms. Chloride is retained & metabolic acidosis can occur. For these reasons, silver sulfadiazine is more commonly used in burn centers unless a major problem with burn wound sepsis is present.", 'role': 'assistant'}]