This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'The treatment of gestational diabetes comprise of: \nSelect and explain. \nA. Glibenclamide, B. Chlorpropamide, C. Glipizide, D. Insulin', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Gestational diabetes is deﬁned as "glucose intolerance ﬁrst detected during pregnancy which returns to normal following termination of pregnancy". It is associated with 2 to 3-fold increase in perinatal\xa0 mortality. It is frequently associated with macrosomia, stillbirth and polyhydramnios. To restrict the plasma glucose levels around 100 mg % insulin may be required.\xa0\nSulfonylureas cross the placental\xa0 barrier and are likely to exert their action on fetal pancreas.\nIt is better to use human insulin or monocomponent puriﬁed insulins, as they are less antigenic.', 'role': 'assistant'}]