This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of lipid, Subject name: Biochemistry
[{'content': 'Niemann-Pick disease occurs due to a defect in \nSelect and explain. \nA. Ceramidase, B. Sphinogomyelinase, C. Phospholipase C, D. b - galactosidase', 'role': 'user'}, {'content': 'Answer: B \nExplanation: DiseaseEnzyme DeficiencyClinical SymptomsNiemann-Pick diseaseSphingomyelinaseEnlarged liver and spleen, mental retardation;fatal in early lifeRef: Harper&;s Biochemistry; 30th edition; Chapter 24 Metabolism of Acylglycerols & Sphingolipids', 'role': 'assistant'}]