This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of lipid, Subject name: Biochemistry
[{'content': 'Krabbes&; disease is due to deficiency of \nSelect and explain. \nA. Sphingomyelinase, B. Beta galactocerebrosidase, C. Hexosaminidase, D. Arylsulfatase', 'role': 'user'}, {'content': "Answer: B \nExplanation: Krabbe's DiseaseAn inherited disorder of lipid metabolism, a lipid storage disease (lipidosis)Enzyme deficiency: Galactocerebrosidase (bbb-galactosidase). The enzyme normally catalyzes the hydrolysis of galactocerebrosides and it splits the linkage between ceramide and galactoseNature of lipid accumulating: Galactosylceramide Clinical manifestations:Severe mental retardation in infantsTotal absence of myelin in central nervous system Globoid bodies found in white matter of brain. Note: Galactocerebroside is an impoant component of myelin Diagnosis: Depends on the determination of galactocerebrosidase activity in leucocytes and cultured skin fibroblasts. Prognosis: Fatal.Ref: Textbook of Medical Biochemistry, Eighth Edition, Dr (Brig) MN Chatterjea, page no: 62", 'role': 'assistant'}]