This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': "All the following are features of Down's syndrome except – \nSelect and explain. \nA. Brushfield's spots in iris, B. Simian crease, C. Mental retardation, D. Hypertonicity", 'role': 'user'}, {'content': "Answer: D \nExplanation: Clinical features of Down's syndrome\n\nA most striking feature in the neonate is hypotonia and although the diagnosis is usually evident at this time, it may sometimes be missed if the baby is very premature or his facial features are concealed by ventilatory apparatus.\n\nCLINICAL FEATURES IN DOWN SYNDROME\n\nGeneral\n\nNeonatal hypotonia\nMild-moderate mental retardation\nShort Stature\n\nCranio-facial\n\nBrachycephaly\nClinodactyly\nEpicanthic folds\nProtruding tongue\nSmall ears\nUpward sloping palpebral fissures\nStrabismus and/or nystagmus\nBrushfield spots in the iris\n\nIncreased incidence of leukaemia (1%)\nLimbs\n\nFifth finger clinodactyly\nSingle palmar crease (simian crease)\nThe wide gap between first and second toes\n\nOther\n\nCongenital heart disease (40%) e.g. common atrioventricular canal, ASD, PDA, VSD, Fallot tetralogy\nAnal atresia & Hirschsprung disease\nDuodenal atresia & annular pancreas\nHypothyroidism & DM\nDelayed fontanel closure\nThree fontanel\nObesity & obstructive sleep apnea", 'role': 'assistant'}]