This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Genetics And Genetic Disorders, Subject name: Pediatrics
[{'content': 'The population frequency for phenylketonuria is 1 in 10,000. What is the carrier frequency for the disease? \nSelect and explain. \nA. Jan-50, B. 1/100, C. 1/500, D. 1/1000', 'role': 'user'}, {'content': "Answer: A \nExplanation: a. 1/50(Ref: Nelson's 20/e p 598)It is based on Hardy Weinberg principle: Simplifying it,Carrier frequency for an autosomal recessive disorder = twice the square root of disease incidenceSo 2 X square root of 1/10,000 gives 1/50 as the answer.", 'role': 'assistant'}]