This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'In nephrotic syndrome the essential feature is : \nSelect and explain. \nA. Proteinuria, B. Hypoalbuminemia, C. Hyperlipernia, D. Edema', 'role': 'user'}, {'content': 'Answer: A \nExplanation: All the given options occur in nephrotic syndrome, but proteinuria is the most characteristic, which is the basic defect.\nThe underlying abnormality in nephrotic syndrome is an increase in permeability of the glomerular capillary wall, which leads to massive proteinuria and hypoalbuminemia.', 'role': 'assistant'}]