This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cytogenetic Disorders, Subject name: Pathology
[{'content': 'Which type of mutation occurs in sickle cell anemia? \nSelect and explain. \nA. Crossover mutation, B. Frameshift, C. Deletion, D. Point mutation', 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans. is 'd' i.e., Point mutation o In sickle cell anemia there is missense type of point mutation.Mis-sense mutationso If the base substitution changes the code words, i.e. codon containing the changed base codes for different amino acid, it is called mis-sense mutation . in sickle mutation CTC codon at position 6 of P-globin chain of hemoglobin that codes for glutamic acid is changed to CAC codon that codes for valine.", 'role': 'assistant'}]