This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General Pharmacology, Subject name: Pharmacology
[{'content': 'Maximum first pass metabolism is seen by which route: \nSelect and explain. \nA. Oral, B. Subcutaneous, C. Rectal, D. Sublingual', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. A. OralWhen drug is administered orally, it goes into portal circulation, then goes into the liver and thus reaching the site of action. First pass metabolism is seen with oral and rectal route.', 'role': 'assistant'}]