This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pharmacokinetics, Subject name: Pharmacology
[{'content': 'Glucuronidation takes place in - \nSelect and explain. \nA. Liver, B. RBC, C. Pancreas, D. Thyroid', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Liver GLUCLROMDATIONo This is the most important synthetic reaction carried out by a group of UDP-glucuronosyl transferases (UGTs).o Glucuronidation occurs mainly in the liver, although the enzyme responsible for its catalysis, UDP-glucuronvltransferase, has been found in all major body organs (e.g., intestine, kidneys, brain, adrenal gland, spleen, and thymus).o Compounds with a hydroxyl or carboxylic acid group are easily conjugated with glucuronic acid which is derived from glucose.o Examples are- chloramphenicol, aspirin, paracetamol, lorazepam, morphine, metronidazole,o Not only drugs but endogenous substrates like bilirubin, steroidal hormones and thyroxine utilize this pathway.o Glucuronidation increases the molecular wreight of the drug which favours its excretion in bile,o Drug glucuronides excreted in bile can be hydrolysed bybacteria in the gut-the liberated drug is reabsorbed and undergoes the same fate. This enterohepatic cycling of the drug prolongs its action, e.g. phenolphthalein, oral contraceptives.", 'role': 'assistant'}]