This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autacoids, Subject name: Pharmacology
[{'content': 'The therapeutic efficiency of antihypeensive drugs is blunted by NSAIDs because they \nSelect and explain. \nA. Cause of sodium excretion, B. Increase the clearance of anti Hypeensive drugs, C. Decrease the absorption of antihypeensive drugs, D. Decrease the synthesis of Vascular prostacyclin', 'role': 'user'}, {'content': 'Answer: D \nExplanation: PG E2 and PGI2 cause renal vasodilatation, natriuresis and increased water clearance due to inhibition of the action of ADH. Loop diuretics act paly by increasing the stimulation of cox. therefore NSAIDs attenuate the diabetic action of these drugs. Refer kDT 6/e p708', 'role': 'assistant'}]