This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NSAIDs, Gout and Rheumatoid Ahritis, Subject name: Pharmacology
[{'content': 'NSAID proposed to be acting inhibition of COX-3 is: \nSelect and explain. \nA. Nimesulide, B. Paracetamol, C. Ketorolac, D. Rofecoxib', 'role': 'user'}, {'content': 'Answer: B \nExplanation: - Paracetamol or acetaminophen has antipyretic and analgesic activities but it lacks anti-inflammatory action. - It is presumed to become inactive by peroxides generated at the site of inflammation therefore, lacks anti- inflammatory action. - Some theories suggest that PCM acts on COX-3 receptors in brain. - A metabolite of paracetamol is assumed to work through vanilloid receptor TRPV-1.', 'role': 'assistant'}]