This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Disorders of Amino acid Metabolism, Subject name: Pediatrics
[{'content': 'A 5-day-old child presents with intractable seizures. He had rashes all over the body. Blood examination showed hyperammonemia and lactic acidosis. The probable diagnosis is: \nSelect and explain. \nA. Organic acidemia, B. Mitochondrial encephalopathy with lactic aciduria, C. Phenylketonuria, D. Urea cycle enzyme deficiency', 'role': 'user'}, {'content': 'Answer: A \nExplanation: -Presence of hyperammonemia along with lactic acidosis in a child with neurological and cutaneous manifestations suggests a diagnosis of Organic acidemia. -C/F of Organic acidemia: Lethargy, poor feeding, coma, vomiting, seizures, developmental delay, dystonia, specific odour -Investigation findings: Metabolic acidosis, lactic acidosis, ketosis, Hyperammonemia , Hypoglycemia , Neutropenia. Types of Organic Acidemia: Maple syrup urine disease Methylhmalonic acidemia Propionic acidemia Multiple Carboxylase deficiency Glutaric acidemia Isovaleric acidemia OTHER OPTIONS: Mitochondrial encephalopathy with lactic aciduria- stroke like episodes Phenylketonuria- microcephaly, epilepsy, musty body odour, reduced skin/hair/eye pigmentation Urea cycle enzyme deficiency- poor feeding, seizures, no rash', 'role': 'assistant'}]