This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Diuretics and Antidiuretics, Subject name: Pharmacology
[{'content': 'Drug of choice for central diabetes insipidus is: \nSelect and explain. \nA. Desmopressin, B. Leuprolide, C. Thiazide diuretics, D. Insulin', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. (A) Desmopressin(Ref: CMDT 2010/996)*Desmopressin is treatment of choice for central diabetes insipidus.*It acts selectively at V2 receptors to increase urine concentration and decrease urine flow in a dose-dependent manner.*It is also more resistant to degradation than AVP and has a three to fourfold longer duration of action.*Desmopressin can be given by IV or SC injection, nasal inhalation, or oral tablet.', 'role': 'assistant'}]