This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Hematopoietic stem cell differ from progenitor stem cell in that they can – \nSelect and explain. \nA. Form terminally differentiated cells, B. Produce growth factors, C. Have receptors for anchoring proteins, D. Long term reconstitution of bone marrow', 'role': 'user'}, {'content': 'Answer: D \nExplanation: There are two major types of stem cells\n1) Embryonic stem cells (ES)\n\nThese are pluripotent cells which can differentiate into all the tissues of the human body.\n\n2) Adult stem cells\n\nAdult stem cells have a more restricted differentiation capacity and are usually lineage-specific, i.e.\xa0multipotent or unipotent. There are two types of adult stem cells\n\nA) Bone marrow stem cells\n\nThese are hematopoietic stem cells which reside in bone marrow and differentiate into various blood cells. Although residing mainly in the marrow, a subset circulates normally in the peripheral blood.\nFrom 3 weeks to 3 months of intraembryonic life, hematopoietic stem cells in the yolk sac are the primary\xa0source of blood cells. From 3 months to just before birth stem cells, migrate to the liver, which is the major\xa0organ for hematopoiesis during that period. After birth bone marrow becomes the major source.\nA remarkable observation about hematopoietic stem cells is that they may capable of giving rise to\xa0neurons, hepatocytes, myocardium, bile duct cells, endothelial cells and skeletal muscle. This change in\xa0stem cell differentiation from one cell type to another is called transdifferentiation.\nOther types of bone marrow stem cells are bone marrow stromal cells which can differentiate, depending\xa0on the tissue environment, into chondrocytes, osteoblasts, adipocytes, myoblasts, endothelial cell\xa0precursors.\n\nB) Tissue stem cells\n\nThese are located outside the marrow in sites called niche. These include', 'role': 'assistant'}]