This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Loading drug of dose primarily depends on \nSelect and explain. \nA. Volume of distribution, B. Clearance, C. Rate of administration, D. Half life', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Loading dose; This is a single or few quickly\xa0repeated doses given in the beginning to attain\xa0target concentration rapidly.\nLoading dose = Target Cp * V /F\nCp - concentration, V - volume of distribution, F - oral bioavailability\nThus, the loading dose is governed only by V and not\xa0by Clearance or t1/2', 'role': 'assistant'}]