This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Nervous system, Subject name: Physiology
[{'content': "The hyperkinetic features of the Huntington's disease are due to the loss of \nSelect and explain. \nA. Nigrostriatal dopaminergic system, B. Intrastriatal cholinergic system, C. GABA-ergic and cholinergic system, D. Intrastriatal GABA-ergic and cholinergic system", 'role': 'user'}, {'content': "Answer: C \nExplanation: It is a genetic disease of nervous system inherited as an autosomal dominant disorder usually occurring between 30 and 50 years of age. Site of lesion : There occurs damage to GABAergic and cholinergic neurons of striatum (caudate and putamen ) that project to pallidum The loss of GABAergic pathway to the external pallidum releases inhibition, permitting the hyperkinetic features of the disease to develop. It affects 5 out of 100,000 people worldwide Ref: Ganong's Review of Medical Physiology 26th edition pg no.566", 'role': 'assistant'}]