This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunology Pa 3 (Graft, Autoimmunity, Immunodeficiency Disorders), Subject name: Microbiology
[{'content': 'Adenosine deaminase (enzyme) deficiency is associated with: \nSelect and explain. \nA. Severe combined immunodeficiency (SCID), B. X-linked agammaglobulinemia, C. Transient hypogammaglobulinemia of infancy, D. Chronic granulomatous disease', 'role': 'user'}, {'content': 'Answer: A \nExplanation: SCID- defect in common gamma chain of IL2 receptor along with IL-4,7 2nd M/C defect is -ADA deficiency total absence of T and B cell deficiency of PNP (purine nucleoside phosphorylase) X-linked agammaglobulinemia/ bruttons agamma globulinemia- defect in B tyrosine kinase gene pro B cell to pre B cell formation defect Transient hypogammaglobulinemia- delayed onset of normal IgG synthesis, self limiting. Chronic granulomatous disease- deficiency of NADPH oxidase. led to reccurent catalase positive infection eg.:-staph.', 'role': 'assistant'}]