This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunology Pa 2 ( Hybridoma Technology, Complement Pathways, Interferon, Structure and Functions of Immune Cells ), Subject name: Microbiology
[{'content': 'All are true regarding superantigens except? \nSelect and explain. \nA. Activate very large numbers of B cells, B. Bind outside the antibody binding groove, C. Are medium sized proteins, D. Cause release of cytokines', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Superantigens activate very large number of T cells. NON -MHC restricted They are medium sized proteins which Attach to TCR on lateral side on Vb (Variable) domain, outside the antibody binding groove. They cause release of cytokines that induce >20% of T lymphocytes activation resulting in massive proliferation of T lymphocytes. They have high resistance to proteases.', 'role': 'assistant'}]