This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Irreversible cell injury is indicated by - \nSelect and explain. \nA. Accumulation of calcium in mitochondria, B. Myelin figures, C. ATP depletion, D. Shifting of ribosomes', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Accumulation of calcium in mitochondrion Large, flocculant, amorphous densities in mitochondrial matrix develop due to increased Ca+2 influx. Note : o Small (not large) phospholipid rich amorphous densities are found in reversible injury.", 'role': 'assistant'}]