This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': 'Chromophobe variant of Renal cell carcinoma is associated with : \nSelect and explain. \nA. VHL gene mutations, B. Trisomy of 7 and 17 (+7, +17), C. 3 p deletions (3p-), D. Monosomy of 1 and Y (-1, -Y)', 'role': 'user'}, {'content': "Answer: D \nExplanation: Answer is D (Monosomy of 1 and y): Chromophobe variants of renal cell carcinoma are charachterized by widespread / extensive chromosomal losses resulting in monosomy or hypodiploid DNA index. This includes loss of chromosome 1 and V. 'The abnormalities most consistently observed have been multiple losses of whole chromosomes, most frequently 1, 2, 6, 10, 13, 17, 21 and the Y chromosome' - Urological Surgical Pathology Classification of epithelial neoplasms arising from the kidney Carcinoma Type Cell of Origin Cytogenetics Clear cell Proximal tubule 3p deletions (3p-), VI IL gene mutations, 5q gains Papillary Proximal tubule Trisomy of chromosome 7 and 17 (+7, +17) Loss of Y chromosome (-Y) Chromophobe Coical collecting duct Hypodiploid / Monosomy Loss of multiple chromosomes 1, 2, 6, 10, 13, 17. 21 & Y Oncocytic Coical collecting duct Undetermined Either karyotypically normal or contain limited number of karyotypic abnormalities including -1, -Y and translocations involving chromosme II Collecting duct Medullary collecting duct Undetermined Losses of multiple chromosomes 1, 6, 14, 15 & 22", 'role': 'assistant'}]