This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
[{'content': 'Concomitant use of valproic acid and lamotrigine increases the risk of : \nSelect and explain. \nA. Chondrodysplasia punctata, B. Paroxysmal Nocturnal hemoglobinuria, C. Stevens-Johnson syndrome, D. Floppy infant syndrome', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Stevens-Johnson syndrome Concomitant use of valproic acid and lamotrigine increases the plasma level of lamotrigine and increases the risk of Stevens-Johnson syndrome; hence, lamotrigine should be staed as a low dose with gradual escalation.', 'role': 'assistant'}]