This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Dyskeratosis - \nSelect and explain. \nA. Leukoplakia, B. Hyperpigmentation, C. Nail dystrophy, D. Premature keratinisation', 'role': 'user'}, {'content': 'Answer: D \nExplanation: DEFINITIONS OF MICROSCOPIC TERMS\nHyperkeratosis\xa0Thickening of the stratum corneum, often associated with a qualitative abnormality of the keratin.\nParakeratosis\xa0Modes of keratinization characterized by the retention of the nuclei in the stratum corneum. On mucous membranes, parakeratosis is normal.\nHypergranulosis\xa0Hyperplasia of the stratum granulosum, often due to intense rubbing.\nAcanthosis\xa0Diffuse epidermal hyperplasia.\nPapillomatosis\xa0Surface elevation caused by hyperplasia and enlargement of contiguous dermal papillae.\nDyskeratosis\xa0Abnormal keratinization occurring prematurely within individual cells or groups of cells below the stratum granulosum.\nAcantholysis\xa0Loss of intercellular connections resulting in loss of cohesion between keratinocytes.\nSpongiosis\xa0Intercellular edema of the epidermis.\nHydropic swelling (ballooning)\xa0Intracellular edema of kerantinocytes, often seen in viral infections\nExocytosis\xa0infiltration of the epidermis by inflammatory or circulating blood cells.\nErosion\xa0Discontinuity of the skin exhibiting incomplete loss of the epidermis.\nUlceration\xa0Discontinuity of the skin exhibiting complete loss of the epidermis and often of portions of the dermis and even subcutaneous fat.\nVacuolization\xa0Formation of vacuoles within or adjacent to cells; often refers to basal cell-basement membrane zone area.\nLentiginous\xa0Referring to a linear pattern of melanocyte proliferation within the epidermal basal cell layer. Lentiginous melanocytic hyperplasia can occur as a reactive change or as part of a neoplasm of melanocytes.', 'role': 'assistant'}]