This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Pharmacology
[{'content': 'Dantrolene sodium reduces skeletal muscle tone by: \nSelect and explain. \nA. Reducing acetylcholine release from motor nerve endings, B. Suppressing spinal polysynaptic reflexes, C. Inhibiting the generation of muscle action potential, D. Reducing Ca2+ release from sarcoplasmic reticulum in the muscle fibre', 'role': 'user'}, {'content': 'Answer: D \nExplanation: * Dantrolene is the drug of choice for the treatment of malignant hypehermia and neuroleptic malignant syndrome. * It acts as an antagonist of Ryanodine receptors (present on smooth endoplasmic reticulum). It inhibits the release of Ca2+ from sarcoplasmic reticulum in the muscle fibre.', 'role': 'assistant'}]