This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Molecular Genetics, Subject name: Biochemistry
[{'content': 'Haemoglobin synthesis starts with? \nSelect and explain. \nA. Glycine, B. Histidine, C. Iron, D. Folic acid', 'role': 'user'}, {'content': 'Answer: A \nExplanation: ANSWER: (A) GlycineREF: Harper 26th e p. 271-275Steps of porphyrin ring synthesis:EnzymeLocationSubstrateProductporphyriaALA synthaseMitochondrionGlycine, sucdnyl CoAD-Aminolevoilinic acidnoneALA dehydrataseCytosolD-Aminolevulinic acidPorphobilinogenALA-DehydratasedeficiencyPEG deaminaseCytosolPorphobilinogenHydroxymethyl bilaneAcuteintermittentporphyriaUroporphyrinogen III synthaseCytosolHydroxymethyl bilaneUroporphyrinogen IIICongenitalerythropoieticporphyriaUroporphyrinogen III decarboxylaseCytosolUroporphyrinogen IIICoproporphyrinogen IIIPorphyria cutanea tardaCoproporphyrinogen III oxidaseMitochondrionCoproporphvrinogen IIIProtoporphyrinogen IXCoproporphyriaProtoporphyrinogenoxidaseMitochondrionProtoporphyrmogen IXProtoporphyrin IXVariegateporphyriaFerrochelataseMitochondrionProtoporphyrin IXHemeErythropoieticprotoporphyriaHeme synthesis--note that some reactions occur in the cytoplasm and some in the mitochondrion (yellow)', 'role': 'assistant'}]