This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Periapical granuloma is mainly composed of: \nSelect and explain. \nA. Macrophages, B. Lymphocytes, C. Plasma cells, D. All of the above', 'role': 'user'}, {'content': 'Answer: D \nExplanation: The apical periodontal cyst is histologically identical with the\xa0periapical\xa0granuloma,\xa0from which it\xa0is\xa0actually\xa0derived, except for the presence of the epithelium-lined lumen.\xa0\nThe lesion is predominantly composed of plasma cells that are mixed with macrophages and lymphocytes with endothelial cells and fibroblasts.\nPeriapical granuloma is not a true granuloma due to the fact that it does not contain granulomatous inflammation; however, periapical granuloma is a common term used.\nReference: Shafer’s Textbook of ORAL PATHOLOGY Eighth Edition page no 78', 'role': 'assistant'}]