This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Ophthalmology
[{'content': 'Lanatoprost used topically in glaucoma primarily acts by: \nSelect and explain. \nA. Decreasing aqueous humour formation, B. Increasing uveoscleral outflow, C. Releasing pupillary block, D. All', 'role': 'user'}, {'content': 'Answer: B \nExplanation: B i.e. Increased uveoscleral outflow Prostaglandin analogues (e.g. latanoprost Q, unprostone, bimatoprost, travoprost) lower intraocular pressure by stimulating a prostanoid receptor in ciliary muscle. This causes the release of matrix metalloproteinases and increase the uveoscleral outflow. Q Latanoprost lower IOP by 25-30% (equivalent to effect produced by timolol). Common side effects are conjunctival hyperaemia, superficial punctate keratopathy & pigmentation. Prostaglandin analogues and pilocarpineQ are contraindicated in inflammatory glaucoma (e.g. glaucoma with uveitis, hypeensive uveitis syndrome) Q. Prostaglandin analogues are 2nd drug of choice after )6 blocker in treatment of open angle glaucoma Q', 'role': 'assistant'}]