This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Bacterial Treatment, Subject name: Microbiology
[{'content': 'A patient is kept on ceftriaxone and amikacin, ESBL Klebsiella infection is detected . What will you do next? \nSelect and explain. \nA. Continue with same antibiotic but in higher dose, B. Change ceftriaxone and add ceftazidime, C. Sta imipenem in place of ceftriaxone, D. Remove Amikacin', 'role': 'user'}, {'content': 'Answer: C \nExplanation: 1. b-lactamase enzymes are capable of hydrolysing the b-lactam rings (the active site) of b-lactam antibiotics; thereby deactivating their antibacterial propeies. ESBL is a Class A b-lactamase enzyme. 2. ESBL (Extended spectrum beta lactamases) are resistant to all Penicillin and 1st/2nd/3rd cephalosporin and monobactam. 3. But do not affect cephamycins (e.g., cefoxitin and cefotetan) or carbapenems (e.g., meropenem or imipenem).', 'role': 'assistant'}]