This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
[{'content': 'Which is wrong about Crigler-Najjar syndrome Type - 1 \nSelect and explain. \nA. Very high level of unconjugated bilirubin occurs in Neonatal period, B. Kernicterus is usual, C. It responds well to phenobarbitone, D. Hepatic histology is normal', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Criggler Najjar syndrome Feature Type 1 Type 2 Total serum bilirubin (mg/dl) 18-45(usually >20)) 6-25(usually 20) Routine liver tests normal Normal Response to phenobarbitone None Decreases bilirubin by >25% Kernicterus Usual Rare Hepatic histology Normal Normal Bile characteristics. Color Pale or colorless pigmented Bilirubin fractions >90% unconjugated Largest fraction (mean:57%) monoconjugates Bilirubin UDP-glucuronosyl transferase activity Typically absent, traces in some patients Markedly reduced :0-10% of normal Inheritance Recessive Predominantly recessive (AR>AD)', 'role': 'assistant'}]