This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Misc., Subject name: Pathology
[{'content': "Pathological findings of Sjogren's syndrome include all except: \nSelect and explain. \nA. Keratoconjunctivitis sicca, B. Glomerular lesion, C. Renal tubular functional defect, D. Salivary gland germinal center lymphocyte deficient", 'role': 'user'}, {'content': 'Answer: D \nExplanation: (D) Salivary gland germinal center lymphocyte deficient # Sjogren Syndrome is a clinicopathologic entity characterized by dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia), resulting from immune-mediated destruction of the lacrimal and salivary glands.> It occurs as an isolated disorder (primary form), also known as the sicca syndrome, or more often in association with another autoimmune disease (secondary form).> Lacrimal and salivary glands are the primary targets, but other secretory glands, including those in the nasopharynx, upper airway, and vagina, may also be involved.> Involved tissues show an intense lymphocyte (primarily activated CD4+ T cells) and plasma-cell infiltrate, occasionally forming lymphoid follicles with germinal centers.> Renal involvement includes interstitial nephritis clinically manifested by hyposthenuria and renal tubular dysfunction with/without acidosis.', 'role': 'assistant'}]