This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'All the following are feature of picks diseases except- \nSelect and explain. \nA. Knife blade atrophy, B. Walnut brain, C. Ballooning degeneration, D. Hirano bodies', 'role': 'user'}, {'content': "Answer: D \nExplanation: Hirano bodies are seen in Alzheimer's disease\n\nPicks disease \n\nPick disease (lobar atrophy) is a progresive dementia characterized clinically by early onset of behavioural changes together with alteraton in personality (frontal lobe signs) and language disturbances (temporal lobe sign).\nPathological findings in Pick disease\nAssymetric atrophy of the frontal and temporal lobes.\nSparing of the posterior two third of superior temporal gyrus, parietal and occipital lobes.\nAtrophy can be severe, reducing the gyri to a thin wafer → Knife-edge appearance.\nBilateral atrophy of caudate nucleus and putamen.\nPick cells (balloned neurons) surviving neurons show characteristic swelling or contain pick bodies, which are cytoplasmic, round to oval, filamentous inclusions that stain strongly with silver methods (argyrophilic).\nPick bodies are composed of tau, straight filament and vesiculated endoplasmic reticulum.", 'role': 'assistant'}]