This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Biochemistry
[{'content': 'Insulin acts on glucose metabolism by \nSelect and explain. \nA. | permeability of glucose across cell membrane, B. | permeability of glucose across cell membrane against glucose gradient, C. | permeability of renal cells, D. | glucose transpo to brain', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Insulin signals the cells of insulin-sensitive peripheral tissues, primarily skeletal muscle, to increase their uptake of glucose.Secondly, insulin acts on the liver to promote glycogenesis.Finally, insulin simultaneously inhibits glucagon secretion from pancreatic a-cells, thus signalling the liver to stop producing glucose glycogenolysis and gluconeogenesis Ref: DM Vasudevan, 7th edition, page no: 165, 318, 323', 'role': 'assistant'}]