This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Which of the following Interleukin is raised in a fever? \nSelect and explain. \nA. IFN-γ, B. TNF-α, C. IL-10, D. IL-2', 'role': 'user'}, {'content': 'Answer: B \nExplanation: i.e., TNF-α \n“IL-1 and TNF-α are the two most important pyrogens” — Physiology basics.\nPyrogens\n\nPyrogens are substances that cause fever.\nPyrogens may be exogenous or endogenous\n\na) Exogenous → Bacterial toxins\nb) Endogenous → IL-1, TNF-a, IL-6, Interferons, Ciliary\xa0neurotrophic factor\n\nThese pyrogens increase the level of PGE2 in the hypothalamus that elevates the thermoregulatory set\xa0point and causes fever.', 'role': 'assistant'}]