This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Lipid Oxidation and Synthesis, Subject name: Biochemistry
[{'content': 'Type 2 hypercholesterolemia occurs due to - \nSelect and explain. \nA. Lipoprotein lipase deficiency, B. Absence of LDL receptors on cells, C. Abnormality in apo E, D. LCAT deficiency', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Ans. is \'b\' i.e., Absence of LDL receptors on cells Primary\' hyperlipoproteinemias caused by known single gene mutationsGenetic DisorderGene DefectLipoproteinsCI/fGenetic transmission1.Lipoprotein lipase deficiencyLPLChylomicronsEruptive xanthomas, HSM, pancreatitisAR2Familial apolipoprotein C-II deficiencyApoC-IIChylomicrons"---------------"AR3.Apo A-V deficiencyApoA-VChylomicrons VLDL"---------------"AD4.Familial hepatic lipase deficiencyHepatic lipaseVLDL remnantsPremature atherosclerosis pancreatitisAR5.Familial dysbetalipoproteinemiaapoEChylomicron and VLDL remnantsPalmar and tuberoeruptive xanthomas, CHD, PVDAR6.Familial hypercholesterolemiaLDL receptorLDLTendon xanthomas, CHDAD7.Familial defective apoR-100apoB-100 (Arg3500-Gln)LDL"---------------"AD8.AD hypercholesterolemiaPCSK9LDL"---------------"AD9.AR hypercholesterolemiaARHLDL"---------------"AR10.SitosterolemiaABCG5 or 8LDL"---------------"AR', 'role': 'assistant'}]