This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Proteins and Amino Acids, Subject name: Biochemistry
[{'content': 'Increased alanine during prolonged fasting represents: \nSelect and explain. \nA. Increased breakdown of muscle proteins, B. Impaired renal function, C. Decreased utilization of amino acid from Gluconeogenesis, D. Leakage of amino acids from cells due to plasma membrane damage', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. A. Increased breakdown of muscle proteinsDuring prolonged fasting, there is increased gluconeogenesis. Alanine provided by muscle is one of the substrates for gluconeogenesis.This is called Glucose Alanine Cycle or Cahill Cycle.So plasma level of Alanine rises in prolonged starvation.Remember:In prolonged fasting plasma level of Alanine rises.In hyperammonemia plasma level of Glutamine rises.', 'role': 'assistant'}]