This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Werner syndrome is characterized by: \nSelect and explain. \nA. Defect in DNA polymerase & impaired cell replication, B. Defect in telomerase & predisposition to cancer, C. Defect in transcription with accumulation of abnormal proteins, D. Defect in DNA helicase & premature aging', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Defect in DNA helicase & premature aging', 'role': 'assistant'}]