This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': 'Characteristic of mixed connective-tissue disease are all of the following except: March 2005 \nSelect and explain. \nA. Hypogammaglobulinemia, B. Membranous glomerulonephritis, C. Polyahritis, D. CNS involvement', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. A: Hypogammaglobulinemia Manifestations of mixed connective-tissue disease (MCTD) can be variable. Most patients experience Raynaud phenomenon, ahralgia/ahritis, swollen hands, sclerodactyly or acrosclerosis, and mild myositis. The following may be revealed by history or physical examination: Raynaud phenomenon Ahralgia/ ahritis Esophageal hypomotility Pulmonary dysfunction Swollen hands Myositis Rash Leukopenia Sclerodactyly Pleuritis/ pericarditis Pulmonary hypeension Membranous glomerulonephritis Lab investigations shows features of inflammation with elevated ESR and hypergammaglobulinemia', 'role': 'assistant'}]