This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'HER-2/neu gene causes breast carcinoma due to \nSelect and explain. \nA. Overexpression, B. Suppression, C. Mutation, D. Translocation', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Answer- A. OverexpressionHER2/neu or ERBB2 gene which encodes for Receptor tyrosine-protein kinase erbB-2, also known as CD340.Amplification or over-expression of this oncogene has been shown to play an impoant role in the development and progression of ceain aggressive types of breast cancer.', 'role': 'assistant'}]