This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Malabsorbtion Syndrome, Subject name: Medicine
[{'content': 'Which cyclooxygenase plays a role in maintaining GI mucosal integrity? \nSelect and explain. \nA. Cyclooxygenase 1, B. Cyclooxygenase 2, C. Cyclooxygenase 3, D. Cyclooxygenase 4', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Cyclooxygenase 1- plays a role in maintaining GI mucosal integrity The beneficial effects of NSAIDs on tissue inflammation are due to inhibition of COX-2 S/E of NSAIDs: GI mucosal ulceration and renal dysfunction- due to inhibition of the COX-1 isoform. Highly COX-2-selective NSAIDs- provide the beneficial effect of decreasing tissue inflammation & minimizing toxicity in the GI tract. Selective COX-2 inhibitors have had adverse effects on CVS, leading to increased risk of myocardial infarction.', 'role': 'assistant'}]