This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Nucleotides, Subject name: Biochemistry
[{'content': 'Orotic aciduria is due to deficiency of- \nSelect and explain. \nA. Decarboxylase, B. Isomerase, C. Tyrosinase, D. Homogentisate oxidase', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Oroticaciduria is a rare, Autosomal recessive disorder. It is the most common metabolic error in Pyrimidine Synthesis. OP (Orotate Phospho Ribosyl Transferase) & Decarboxylase are bifunctional enzymes in pyrimidine synthesis. There are two types of Orotic acidurias: Type I : Both enzymes deficient i.e. OP(Orotate Phosphoribosyl Transferase) and OMP Decarboxylase(it is a bifunctional enzyme) Type II - Only one enzyme deficient (mostly OMP decarboxylase)', 'role': 'assistant'}]