This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
[{'content': 'Dermatomyositis associated with Anti-Mi2 antibodies shows strong association with \nSelect and explain. \nA. Heliotrope rash, B. Mechanic hands, C. Butterfly rash, D. Discoid rash', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Dermatomyositis is a systemic autoimmune disease that typically presents with proximal muscle weakness and skin changes. Ceain autoantibodies tend to be associated with specific clinical features:Anti-Mi2 antibodies (directed against a helicase implicated in nucleosome remodeling) show a strong association with prominent Gottron papules and heliotrope rash )Anti-Jo1 antibodies (directed against the enzyme histidyl t-RNA synthetase) are associated with interstitial lung disease, nonerosive ahritis, and a skin rash described as "mechanic\'s hands."Anti-P155/P140 antibodies (directed against several transcriptional regulators) are associated with paraneoplastic and juvenile cases of dermatomyositis.Butterfly and Discoid rash are seen in SLERef: Robbins and Cotran Pathologic Basis of Disease; 9th edition; Chapter 27; Peripheral Nerves and Skeletal Muscles; Page no: 1238', 'role': 'assistant'}]