This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
[{'content': 'Colchicine mechanism of action in acute gout \nSelect and explain. \nA. Inhibition of release of chemotactic factors, B. Binding to tubulin and inhibition of leucocyte migration, C. Promotes metabolism of urate crystals, D. Inhibition of leukotriene B4', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Ref. KDT. Page. 214\nIt does not inhibit the synthesis or promote the excretion of uric acid. – Direct lines from Tripathi, guides may lead you wrong. But they don’t have an effect \n\xa0\nColchicine MOA\nThe first two points is how it acts in acute Gout\n\nColchicine does not affect phagocytosis of urate crystals but inhibits release of the glycoprotein and the subsequent events.\nBy binding to fibrillar protein tubulin, it inhibits granulocyte migration into the inflamed joint and thus interrupts the vicious cycle.\nAntimitotic: causes metaphase arrest by binding to microtubules of mitotic spindle.\nIncreases gut motility through neural mechanisms', 'role': 'assistant'}]