This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'Molecular change in Lysosomal storage disorder is: \nSelect and explain. \nA. Defective fusion of lysosomes and phagosomes, B. Increased synthesis of some substrates, C. Mutation of genes encoding lysosomal hydrolases, D. Membrane defect of lysosomes', 'role': 'user'}, {'content': 'Answer: C \nExplanation: C i.e. Mutation of genes encoding lysosomal hydrolasesLysosomal storage diseases (LSD) are caused by mutations in genes encoding lysosomal hydrolasesQ responsible for breaking down of macromolecules, which results in accumulation of corresponsing substrate (macromolecule). ISDs are classified on the basis of accumulated substrate into sphingolipidosis, mucolipidosis, mucopolysaccharidoses, glycoproteinoses etc.', 'role': 'assistant'}]