This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Liver & Biliary Tract, Subject name: Pathology
[{'content': 'A 48-year-old woman has a 3-week history of fatigue as well as yellow skin and sclerae. Physical examination is unremarkable except for mild jaundice. The serum bilirubin level is 3.7 mg/dL, mostly in the unconjugated form. Liver function tests including serum AST, ALT, and alkaline phosphatase are normal. The hemoglobin level is 6.0 g/dL. After corticosteroids are administered, the jaundice resolves. Which of the following diseases is the most likely cause of hyperbilirubinemia in this patient? \nSelect and explain. \nA. Acute hepatitis B infection, B. Autoimmune hemolytic anemia, C. Gallstone in the common bile duct, D. Primary biliary cirrhosis', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Autoimmune hemolytic anemia is characterized by antibody-mediated erythrocyte destruction and may lead to severe anemia, as in this case. Intravascular hemolysis produces increased serum levels of unconjugated bilirubin, which exceed the capacity of the hepatocyte to conjugate bilirubin. In most cases, the disease is ameliorated by treatment with corticosteroids. The other choices are parenchymal liver diseases that manifest primarily as conjugated hyperbilirubinemia and are unresponsive to steroids.Diagnosis: Autoimmune hemolytic anemia', 'role': 'assistant'}]