This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Pharmacology
[{'content': 'The immunosuppressant action of cyclosporine appears to be due to: \nSelect and explain. \nA. Activation of NK cells, B. Blockade of tissue responses to inflammatory mediators, C. Inhibition of gene transcription of interleukins, D. Interference with antigen recognition', 'role': 'user'}, {'content': 'Answer: C \nExplanation: (Ref: KDT 6/e p838, 839,840) Cyclosporine and tacrolimus acts by inhibiting calcineurin, which is involved in the activation of NFAT. Final result of this process is increased transcription of IL-2 gene. Sirolimus does not inhibit the transcription of IL-2 but interferes with its action. It inhibits the enzyme tyrosine kinase, known as mTOR (which is activated byIL-2)', 'role': 'assistant'}]