This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Sterility is caused by - \nSelect and explain. \nA. Vinca alkaloids, B. Alkylating agents, C. Antimetabolites, D. Actinomycin D', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e., Alkylatings agents Alkylating agents may contribute to sterility by the following effects : Azoospermia in males Amenorrhea and ovarian atrophy in females Specific toxicity of impoant alkylating agents. o Cyclophosphamide ---> Cystitis, alopecia, SIADH o Ifosfamide ---> Cystitis, SIADH, neurotoxicity o Cisplatin ---> Nephrotoxicity, peripheral neuropathy, ototoxicity, vomiting. o Busulfan ---> Adrenal insufficiency, hyperpigmentation,pu/monaryfibrosis. o Procarbazine ---> Disulfiram like reaction, secondary leukemias, CNS effects.", 'role': 'assistant'}]