This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.V.S, Subject name: Medicine
[{'content': 'All are the true regarding hyperophic obstructive cardiomyopathy, except- \nSelect and explain. \nA. Systolic dysfunction, B. Concentric hyperophy, C. Diastolic dysfunction, D. Double apical impulse', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ref:Harrison's 19th E pg 1569 It is diastolic dysfunction. At the level of the sarcomere, hyperophic cardiomyopathy mutations lead to enhanced calcium sensitivity, maximal force generation, and ATPase activity. Calcium handling is affected through modification of regulatory proteins. Sarcomere mutations lead to abnormal energetics and impaired relaxation, both directly and as a result of hyperophy.", 'role': 'assistant'}]