This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Vulvar cancer, Subject name: Gynaecology & Obstetrics
[{'content': 'A Postmenopausal woman presents with pruritic white lesions on the vulva. Punch biopsy of a representative area is obtained. Which of the following histologic findings is consistent with the diagnosis of Lichen sclerosis? \nSelect and explain. \nA. Blunting or loss of Rete pegs, B. Excessive hyalinisation, C. Acute inflammatory infiltration, D. Increase in the number of cellular layers in the epidermis', 'role': 'user'}, {'content': "Answer: A \nExplanation: Lichen Sclerosis Small bluish-white papules that coalesce into white papules Pruritus('Itch-scratch' cycle), dyspareunia, dysuria Histology-Moderate hyperkeratosis with epithelial thinning, acanthosis, basement membrane thickening. Loss of rete hyalinization in dermis Ca vulva of Keratinizing types which is Unifocal and seen in older patients, is found in areas adjacent to lichen sclerosis and squamous hyperplasia. Biopsy for Diagnosis Rx- Testosterone cream", 'role': 'assistant'}]