This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Aerial disorders, Subject name: Surgery
[{'content': 'Diabetic gangrene is due to: \nSelect and explain. \nA. Ischemia, B. Increased blood glucose, C. Altered defense by host and neuropathy, D. All of the above', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Diabetic gangrene is related to: - Trophic changes from peripheral neuropathy - Ischemia as a result of microangiopathy and macroangiopathy (atherosclerosis) - Low resistance to infection because of excess sugar in the tissues', 'role': 'assistant'}]