This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Arachidonic acid metabolites, Subject name: Pathology
[{'content': 'All of the following statements are true related to histamine, except: \nSelect and explain. \nA. Histamine is a principal mediator of immediate transient response during acute inflammation., B. It causes dilation of aerioles, C. It increases the permeability of venules, D. Histamine receptor agonists are used to treat allergies.', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Histamine Stored as preformed molecules in mast cells and is therefore among the first mediators to be released during inflammation. Causes dilation of aerioles and increases the permeability of venules. Can cause contraction of some smooth muscles such as in lungs. H1 receptor antagonists that bind to and block the histamine receptors are used to inflammatory reactions (allergies).', 'role': 'assistant'}]