This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
[{'content': 'The dose of folic acid per day for treating megaloblastic anaemia in pregnancy \nSelect and explain. \nA. 400 μg, B. 1 mg, C. 5mg, D. 2 mg', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Folic acid deficiency in Pregnancy\n\nIn nonpregnant women, the folic acid requirement is 50 to 100 μg/day\nDuring pregnancy, requirements are increased and 400 μg/day is recommended\xa0\n\nThe earliest biochemical evidence is low plasma folic acid concentrations\xa0\nNormal serum folate levels\n\nNon Pregnant women: 5.4-18ng/ml\n1st trimester: 2.6-15ng/ml\n2nd trimester: 0.8-24ng/ml\n3rd trimester: 1.4-20.7ng/ml\n\n\nEarly morphological changes usually include\xa0neutrophils that are hypersegmented and newly formed erythrocytes that are macrocytic\n\xa0As the anaemia becomes more intense, peripheral nucleated erythrocytes appear, and bone marrow examination discloses megaloblastic erythropoiesis\nThe fetus and placenta extract folate from maternal circulation so effectively that the fetus is not anaemic despite severe maternal anaemia\n\nTreatment\n\n\xa0As little as\xa01mg\xa0of folic acid administered orally once daily produces a striking haematological response\nBy 4 to 7 days after beginning folic acid treatment, the reticulocyte count is increased, and leukopenia and thrombocytopenia are corrected\nAmerican College of Obstetricians and Gynecologists (2013c) have recommended that all women of childbearing age consume at least 400 μg of folic acid daily\n\nIncreased need of Folic acid\n\nMultifetal pregnancy\nHemolytic anaemia\nCrohn disease\nAlcoholism\nInflammatory skin disorders', 'role': 'assistant'}]