This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Microbiology
[{'content': "Which of the following is granted orphan drug status for the treatment of Dravet's syndrome? \nSelect and explain. \nA. Stiripentol, B. Icatibant, C. Pitolisant, D. Tafamidis", 'role': 'user'}, {'content': "Answer: A \nExplanation: Stiripentol increases GABA transmission. It is granted orphan drug status for the treatment of Dravet's syndrome (Severe myoclonic epilepsy in infants).Icatibant is a bradykinin B2 receptor antagonist. It is used for acute attacks of hereditary angioedema in adults with C1-esterase inhibitor deficiency.Pitolisant (a/k/a Tiprolisant) is an inverse agonist of an H3 receptor. It is under trial for schizophrenia and Parkinson's disease.Tafamidis stabilizes the correctly folded tetrameric form of TTR. It is used in familial amyloid polyneuropathy.", 'role': 'assistant'}]