This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
[{'content': 'Volume of distribution is NOT affected by all EXCEPT \nSelect and explain. \nA. Binding to plasma protein, B. Drug clearance, C. Lipid insolubility, D. Absence of blood brain barrier', 'role': 'user'}, {'content': 'Answer: A \nExplanation: (Binding to plasma protein) (31-33-KDT 6th)* The extent of distribution of drug depends on* Lipid solubility* Ionization at physiological pH (dependent on pKa)* The extent of binding to plasma and tissue proteins* Differences in regional bloodflow', 'role': 'assistant'}]