This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': 'Which one of the following is of most serious prognostic significance in a patient of essential hypertension - \nSelect and explain. \nA. Diastolic blood pressure greater than 130 mmHg, B. Transient ischaemic attacks, C. Left ventricular hypertrophy, D. Papilloedema and progressive renal failure', 'role': 'user'}, {'content': 'Answer: D \nExplanation: None', 'role': 'assistant'}]