This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Which of the following changes in C-MYC oncogene may be associated with colonic malignancy? \nSelect and explain. \nA. Point mutation, B. Amplification, C. Rearrangement, D. Deletion', 'role': 'user'}, {'content': 'Answer: B \nExplanation: C- MYC amplification may be responsible for Ca breast, Ca colon, Ca stomach and lung. L - MYC amplification is associated with Ca lung and bladder. N- MYC amplification is associated with neuroblastoma and Ca lung. Ref: Harrison, 17th Edition, Page 496', 'role': 'assistant'}]