This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Glucose Transpo, Subject name: Biochemistry
[{'content': 'Which of the following DOES NOT depend on insulin for glucose uptake : \nSelect and explain. \nA. Brain, B. Cardiac muscles, C. Skeletal muscles, D. Adipose tissue', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Option a - Brain does not depend on insulin for glucose uptake Glucose uptake occurs in muscles (cardiac & skeletal) & adipose tissue GLUT-4 , which is insulin dependent. Only GLUT-4 is dependent on Insulin. In brain, GLUT-1 & GLUT-3 are present which are active during fasting state. Insulin always acts in a fed state. So, there is no relation between them Hence GLUT1 and 3 are not dependent on insulin.', 'role': 'assistant'}]