This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General Surgery, Subject name: Surgery
[{'content': 'All are true about histo-immunological type of breast cancer EXCEPT: \nSelect and explain. \nA. Molecular classification is based on gene expression profiling, B. Most common type is Luminal A, C. Best Prognosis is Luminal B, D. Worst prognosis is triple negative breast cancer', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Molecular classification of breast Ca is based on gene expression profiling. Molecular classification: Luminal A: ER & PR + ve, double positive HER - 2 - neu (-) ve Ki67 lowMost common type, best prognosis. Luminal B: two subtypes- 1. Luminal B HER(+) ER, PR - positive & Her - 2 - neu positive (triple positive) and Ki67 low/high 2. Luminal B HER(-) ER, PR - positive & Her - 2 - neu negative and Ki67 high Intermediate prognosis Basal cell type: triple negative ER, PR Her-2-neu (-)ve Ki67 high In BRCA 1 mutation most aggressive and Poorer prognosis because there are fewer targeted medicines available Her-2 type: Her-2-neu +veER, PR -ve aggressive and poor prognosis Normal like breast cancer- same like luminal A but prognosis poorer than luminal A Most common: luminal A Best prognosis: Luminal A Worst prognosis: Triple negative breast cancer', 'role': 'assistant'}]