This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Pathology
[{'content': 'Intravascular hemolysis causes - \nSelect and explain. \nA. Hereditary spherocytosis, B. Acute G6PD, C. Thalassemia, D. PNH', 'role': 'user'}, {'content': 'Answer: B \nExplanation: In G6PD defficiency both intravascular and extravascular hemolysis occurs. Here due to decreased synthesis of reduced glutathione ,when RBC exposed to oxidant stress H2O2 get accumulated ,damages RBC membrane causing hemolysis. It usually presents as acute self limited acute intravascular hemolytic anemia. Reference: Exam preparatory manual for undergraduates - Pathology by Ramdas Nayak page no :267 Ref Robbins 9/e pg 410', 'role': 'assistant'}]