This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
[{'content': 'A woman gave bih to a premature baby of 34 weeks. The baby showed bullous lesions all over the body and X-ray shows periosteitis. What should be the next investigation? \nSelect and explain. \nA. VDRL for both mother and baby, B. ELISA for HIV, C. PCR for TB, D. HBsAg for mother', 'role': 'user'}, {'content': "Answer: A \nExplanation: VDRL for both mother and baby.It's a classical clinical picture of congenital syphilis. Bullous lesions are rarely seen in adult form of syphilis but are characteristic of congenital form. VDRL is a sensitive test to diagnose congenital syphilis. Manifestations of congenital syphilis can be classified as follows: 1. Early Manifestations (infectious stage): Within first years of life: Bullous/maculopapular rash, vesicles, Rhinitis and snuffles (earliest sign) Hepatosplenomegaly Lymphadenopathy Hematological: Coomb's negative hemolytic anemia, thrombocytopenia Skeletal: Osteochondritis/Metaphysitis/Pseudoparalysis IUGR: failure to thrive Ocular: Congenital glaucoma, chorioretinitis *CNS: Leptomeningitis, hydrocephalous 2. Residual stigmata Hutchison's teeth, mulberry molars Olympian brow Saddle nose Saber shins 3. Late congenital syphilis (non-infectious) shows: Interstitial keratitis 8th nerve deafness Clutton's joints *Asymptomatic neurosyphilis Recurrent ahropathy", 'role': 'assistant'}]