This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Extravascular Changes, Subject name: Pathology
[{'content': 'Defective phagolysosome is feature of? \nSelect and explain. \nA. Chronic Granulomatous Disease, B. Chediak - Higashi - syndrome, C. Ataxia telangiectasia, D. Fanconi Anemia', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Inherited defects in phagolysosome function. One such disorder is Chediak-Higashi syndrome, Autosomal recessive condition Defective fusion of phagosomes and lysosomes, resulting in defective phagocytes function and susceptibility to infections. The main leukocyte abnormalities are:- Neutropenia Defective degranulation Delayed microbial killing The gene associated with this disorder encodes a large cytosolic protein called LYST, which is believed to regulate lysosomal trafficking.', 'role': 'assistant'}]