This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.V.S, Subject name: Medicine
[{'content': 'In primary pulmonary hypeension basic abnormality in genes lies in \nSelect and explain. \nA. Bone morphogenetic protein receptor II, B. Endothelin, C. Homebox gene, D. PAX-11', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ref Harrison 19 th ed pg 1655 Abnormalities in multiple molecular pathways and genes that regu- late the pulmonary vascular endothelial and smooth muscle cells have been identified ). These abnormalities include decreased expression of the voltage-regulated potassium channel, mutations in the bone morphogenetic protein receptor-2, increased tissue factor expres- sion, overactivation of the serotonin transpoer, hypoxia-induced activation of hypoxia-inducible factor-1a, and activation of nuclear factor of activated T cells.', 'role': 'assistant'}]