This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Biosynthesis of Fatty Acids and Eicosanoids, Subject name: Biochemistry
[{'content': 'In chronic alcoholism the rate limiting component for alcohol metabolism excluding enzymes is/are : (PGI Dec 2008) \nSelect and explain. \nA. NADP, B. NAD+, C. NADPH, D. FADH', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Ans : B (NAD+) & C (NADPH) In chronic alcoholism rate limiting component for alcohol metabolism is NAD* & NADPHOxidation of ethanol by alcohol dehydrogenaseQ & NADQ leads to excess production of NADHSome metabolism of ethanol takes place via a cytochrome P450 dependent microsomal ethanol oxidising systme (MEOS) Q involving NADPH & O2:, This system increase in activity in chronic alcoholism & may account for the increased metabolic clearnce in this condition.Ethanol + NADPH + H+ O2 MEOS Acetaldehyde', 'role': 'assistant'}]