This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': 'Which of the following is most characteristic of the brain in patients with Alzheimer’s disease \nSelect and explain. \nA. Pigmentary degeneration in hippocampus, B. Demyelination in cerebral cortex, C. Posterior column degeneration, D. Neuronal loss in cerebral cortex', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Most prominent feature of alzheimer’s disease is neuronal loss, fibrillary tangles, loss of synapses and amyloid plaque formation.', 'role': 'assistant'}]