This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Antibiotics, Subject name: Pharmacology
[{'content': 'All of the following are true regarding clofazimine except \nSelect and explain. \nA. It is cidal to Mycobacterium leprae, B. It has a very long elimination half life, C. It discolours skin and sweat, D. It has additional antiinflammatory propey', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Clofazimine (Clo) It is a dye with leprostatic and antiinflammatory propeies. Mechanism of action of clofazimine:- * Interference with template function of DNA in M.leprae * Alteration of membrane stucture and its transpo function. * Disruption of mitochondrial electron trans po chain. Clofazimine is used as a component of multidrug therapy (MDT) of leprosy. Because of its antiinflammatory propey, it is valuable in lepra reaction. PHARMACOKINETICS Clofazimine is orally active (40-70% absor bed). It accumulates in macrophages and gets deposited in many tissues including subcutaneous fat, as needle-shaped crystals. However, entry in CSF is poor. The t 1/2 is 70 days so that intermittent therapy is possible Adverse effects:- Skin:- The major disadvantage is reddish-black discolouration of skin, especially on exposed pas. Discolouration of hair and body secretions may also occur. Dryness of skin and itching is often troublesome. Acneform eruptions and phototoxicity have been noted. Conjunctival pigmentation may create cosmetic problem. Ref:- kd tripathi; pg num:-781,782', 'role': 'assistant'}]