This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Medicine
[{'content': 'A 35-year-old woman notices a red rash over her cheeks, and pain and swelling in both knees as well as several small joints in her hands. She has a history of hypertension and 2 months ago was started on a new medication to control her blood pressure. Her ANA and anti-histone antibodies are positive. Which of the following medications is most likely to cause her condition? \nSelect and explain. \nA. hydralazine, B. hydrochlorothiazide, C. ramipril, D. nifedipine', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Hydralazine can cause drug-induced lupus (defined by positive ANA and anti-histone antibodies). About 25-30 % of patients treated chronically with hydralazine will develop ANA positivity and about 10-20% of patients with ANA positivity will develop systemic symptoms compatible with lupus, particularly arthralgias. Genetic variation in drug acetylation rates might be a predisposing factor.', 'role': 'assistant'}]