This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Neoplasia, Subject name: Pathology
[{'content': 'In a FAP patient which is an important CA risk \nSelect and explain. \nA. Retinoblastoma, B. Brain tumor, C. Colorectal CA, D. Prostate CA', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ref: Robbins Pathology, 9th ed. pg. 809* Familial adenomatous polyposis (FAP) is an autosomal dominant disorder in which patients develop numerous colorectal adenomas as teenagers.* Robbins states: "Colorectal adenocarcinoma develops in 100% of untreated FAP patients, often before age 30 and nearly always by age 50"* As a result, prophylactic colectomy is the standard therapy for individuals carrying APC mutations. Colectomy prevents colorectal cancer, but patients remain at risk for neoplasia at other sites.* FAP is also associated with a variety of extraintestinal manifestations:# Congenital hypertrophy of the retinal pigment epithelium# Gardner syndrome and# Turcot syndrome', 'role': 'assistant'}]