This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Medicine
[{'content': 'Mechanism of action colchicine in acute gout \nSelect and explain. \nA. Uric acid nephrolithiasis., B. Deficiency of enzyme Xanthine oxidase, C. Increase in serum urate concentration, D. Renal disease involving interstitial tissues', 'role': 'user'}, {'content': 'Answer: B \nExplanation: * Gout is a hereditary disorder with increase in serum uric acid due to increased production, or decreased excretion of uric acid and uric salt. * Thought to be caused by lack of an enzyme needed to completely metabolise purines for renal excretion. REF : HARRISONS 21ST ED', 'role': 'assistant'}]