This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': "Skip granulomatous lesions are seen in – \nSelect and explain. \nA. Ulcerative colitis, B. Crohn's disease, C. Whipple's disease, D. Reiter's disease", 'role': 'user'}, {'content': 'Answer: B \nExplanation: Features of CD\n\nIn the affected segment, mesenteric fat wraps around the bowel surface → creeping fat\nThe intestinal wall is rubbery and thick, as a consequence of oedema, inflammation, fibrosis, and hypertrophy of the muscularis propria → lumen is almost always narrowed → string sign on barium meal.\nA classic feature of CD is the sharp demarcation of diseased bowel segments from adjucent uninvolved bowel.\nWhen multiple bowel segments are involved, the intervening bowel is normal to skip lesions.\nThere is serpentine linear ulcer along the axis of the bowel.\nAs the intervening mucosa tends to be relatively spared, the mucosa acquires a coarsely textured → Cobblestone appearance.\nNarrow fissures develop between the folds of the mucosa.\nFissures can penetrate deeply through the bowel wall and leading to bowel adhesions and serositis.\nFurther extension of fissures leads to fistula or sinus tract formation.\nThere is transmural inflammation affecting all layers of the bowel wall.\nSarcoid-like noncaseating granulomas may be present in all tissue layers.\nNeutrophilic infiltration into the crypts results in the formation of crypt abscess.\nFibrosis of the submucosa, muscular propria, and mucosa eventually leads to stricture formatting.\nThere is an increased incidence of cancer of GIT in patients with long-standing CD, but the risk of cancer in CD is considerably less than in patients with chronic UC.', 'role': 'assistant'}]