This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
[{'content': 'True statement about female genital tuberculosis: \nSelect and explain. \nA. Genital tract involvement results from lymphatic spread, B. Premenstrual histopathological examination is diagnostic, C. Polymerase chain reaction (PCR) techniques have got higher sensitivity in detection, D. Reproductive outcome  following  antituberculous chemotherapy is satisfactory', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Genital tuberculosis is usually secondary to primary infection (lungs, bones, lymph nodes).\nIt spreads by haematogenous route (not lymphatic route) leading to endosalpingitis.\nCaseous granulomatous lesions with giant cells on pathological examination are suggestive of TB but is not diagnositic as it can be seen in fungal infection and sarcoidosis.\nPCR is more sensitive (85–95%) than microscopy and bacteriological culture. This method can detect fewer than 10 organisms in clinical specimens compared to 10,000 necessary for smear positivity.\nReproductive outcome even after treatment is poor. Pregnancy rate is about 20%, live birth rate is only 7%. risk of miscarriae and ectopic pregnancy are high.', 'role': 'assistant'}]