This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Basics of carbohydrate metabolism, Subject name: Biochemistry
[{'content': 'Which vitamin is required for glucose 6 phosphate dehydrogenase? \nSelect and explain. \nA. Riboflavin, B. Thiamine, C. Niacin, D. Biotin', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Niacin - pyridine derivative. Coenzyme forms - NADP+, NAD+ The coenzymes NAD+ and NADP+ are involved in a variety of oxidation-reduction reactions Selected example of NAD+ & NADP+ dependent enzyme NAD+ Enzyme Coenzyme Isocitrate dehydrogenase NAD+ a- Ketoglutarate dehydrogenase NAD+ Glucose 6-phosphate dehydrogenase NADP+ Malate dehydrogenase NAD+ Glutamate dehydrogenase NAD+ Glyceraldehyde 3-phosphate dehydrogenase NAD+ or NADP+ Lactate dehydrogenase NAD+ Alcohol dehydrogenase NAD+ NOTE: Niacin causes hyperglycemia. Niacin induces pancreatic islet dysfunction through activation of the islet beta-cell G-coupled protein receptors that mediate peroxisome proliferation and increase reactive oxygen species. It also decreases glucose-stimulated insulin secretion. Thus, it increases the blood glucose level and is contraindicated in diabetics.', 'role': 'assistant'}]