This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'All of the following statements regarding apoptosis are TRUE, EXCEPT: \nSelect and explain. \nA. Considerable apoptosis may occur in tissues before it becomes apparent in histology, B. Apoptotic cells appear round mass of the intensely eosinophilic cytoplasm with dense nuclear chromatin fragments, C. Apoptosis of cells induce inflammatory reaction, D. Macrophages phagocytose the apoptotic cells and degrade them.', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Apoptosis refers to preprogrammed natural or physiological cell death. It occurs without any inflammatory reaction. Features of apoptosis are: Death occur by shrinkage It affects isolated cells It is a gene initiated process, and DNA fragments are small and regular Histologic features: Cell shrinkage Nuclear condensation and fragmentation Membrane budding Buds includes cell organelles Buds detach to form apoptotic bodies Phagocytosis of the apoptotic bodies occur Ref: Textbook of Pathology By Datta page 48.', 'role': 'assistant'}]