This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Drugs in Pregnancy, Subject name: Gynaecology & Obstetrics
[{'content': 'In a pregnant woman, all can be given for SLE, EXCEPT: \nSelect and explain. \nA. Methotrexate, B. Sulfasalazine, C. Hydroxychloroquine, D. Prednisone', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Methotrexate Category X drug (FDA), highly Teratogenic. Should avoid during pregnancy, if there is a risk of becoming pregnant, or if they are breastfeeding. Can be toxic to the embryo and can cause fetal defects and spontaneous aboion. Females should discontinue use for at least 1 ovulatory cycle before conception and the male patients should stop taking methotrexate at least 3 months prior to a planned conception.', 'role': 'assistant'}]