This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Medicine
[{'content': 'A 14-year-old girl on exposure to cold has pallor of extremities followed by pain and cyanosis. In later stages of life she is most prone to develop: \nSelect and explain. \nA. SLE, B. Scleroderma, C. Rheumatoid ahritis, D. Dermatomyositis', 'role': 'user'}, {'content': "Answer: B \nExplanation: Pallor of extremities, followed by pain and cyanosis suggests a diagnosis of Raynaud&;s phenomenon. Raynaud's as the presenting manifestation is most strongly associated with scleroderma.Raynaud's is associated with viually every patient of scleroderma(98-99%)It is the presenting complaint in 70% of patients with sclerodermafeatureLimited sclerodermaDiffuse sclerodermaRaynaud's phenomenon99%98%Secondary causes of Raynaud's phenomenon:Rheumatologic:SclerodermaSLERASjogren's syndromeDermatomyositisPolymyositisvasculitisDrugs:sympathomimetics(decongestants, diet pills)serotonin agonists(sumatriptan)chemotherapeutics(bleomycin, cisplatin,carboplatin)ergotaminecaffeinenicotineHaematologic disorders:cryoglobulinemiaparaproteinemiapolycythemiacold agglutininsVasospasm:migraine headachesMechanical:vibration injuryfrostbitethoracic outlet syndromevascular embolus or occlusionEndocrine disorders:hypothyroidismcarcinoid syndromepheochromocytomaRef: Harrison's 18/e p2763, 17/e p2096, 2101", 'role': 'assistant'}]