This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
[{'content': 'Congenital adrenal hyperplasia (CAH) is associated with which of the following? \nSelect and explain. \nA. Male pseudohermaphroditism, B. Female pseudohermaphroditism, C. True hermaphroditism, D. Cushing syndrome', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Ref. Guyton. 13th edition. Page. 781\nCongenital Adrenal Hyperplasia Types\n21 β-Hydroxylase deficiency\n\nAccounts for about 90% of the cases \u2028\n75% of the cases have mineralocorticoid deficiency \u2028\nNeonates may present with a salt-wasting crisis. \u2028\nSalt wasters tend to have hyponatremia, hyperkalemia, and raised plasma renin. \u2028\n17-hydroxyprogesterone is elevated. \u2028\nIncreased androgens lead to virilization of the female fetus and sexual ambiguity at birth \u2028\nMales are phenotypically normal at birth but develop precocious pseu- do puberty, growth acceleration, premature epiphyseal plate closure, and diminished final height. \u2028\nGoal in treatment is to bring glucocorticoid and mineralocorticoid back to the normal range which would also suppress adrenal androgen secretion. \u2028\nGive hydrocortisone to act as feedback inhibition on pituitary\n\n11 β-Hydroxylase deficiency \u2028\n\nClinical features of increased androgens similar to the preceding form, \u2028including virilization of female fetus. \u2028\nThe principal difference with this form is the hypertension produced by 11-deoxycorticosterone, along with hypokalemia and suppressed renin secretion. \u2028\nTreatment for all forms of CAH is glucocorticoids such as hydrocortisone and dexamethasone. \u2028\n\n17 α-Hydroxytlase deficiency \u2028\n\nExtremely rare \u2028\nUsually diagnosed at the time of puberty when the patient presents with hypertension, hypokalemia, and hypogonadism \u2028\nIndividuals have eunuchoid characteristics.', 'role': 'assistant'}]