This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Pathology
[{'content': 'Leiden mutation is associated with? \nSelect and explain. \nA. Factor IV, B. Factor V, C. Factor VIII, D. Factor IX', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Leiden mutation is associated with factor 5.This is also a autosomal dominant disorder in which mutation lies in the replacement of arginine by glycine at position 506.Most common cause of thrombophilia. Reference :Harsh Mohan textbook of pathology 7th edition.Pg no.102', 'role': 'assistant'}]