This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Fluid & Electrolyte, Subject name: Medicine
[{'content': 'Most serious side effect with sodium polystyrene sulfonate - \nSelect and explain. \nA. Intestinal perforation, B. Rebound hyperkalemia, C. Cardiac arrest, D. Respiratory arrest', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Intestinal perforation o Sodium polystyrene sulfonate (SPS) exchanges Na+ for K+ in the gastrointestinal tract and increases the fecal excretion of K+.It causes slow increase in serum K+ concentration.The full effect may take up to 24 hours and usually requires repeated doses every 4-6 hours.Intestinal necrosis is the most serious complication of SPS.", 'role': 'assistant'}]