This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Non Hodgkin Iymphoma, Subject name: Pathology
[{'content': "Which is the following is an example of low grade Non-Hodgkin's lymphoma? \nSelect and explain. \nA. Follicular lymphoma, B. Burkitt lymphoma, C. Diffuse large cell lymphoma (DLBCL), D. Lymphoblastic lymphoma", 'role': 'user'}, {'content': "Answer: A \nExplanation: Follicular Lymphoma is a low grade non-Hodgkin's lymphoma Most common form of indolent lymphoma in adults. Hallmark is a (14;18) translocation that juxtaposes the IGH locus on chromosome 14 and the BCL2 locus on chromosome 18. The t(14;18) is seen in up to 90% of follicular lymphomas and leads to overexpression of BCL2. Tumor cells comprise of small lymphoid cells with condensed chromatin and irregular or cleaved nuclear outlines (centrocytes) are mixed with a population of larger cells with nucleoli (centroblasts). Following image shows Follicular lymphoma (variably-sized follicles effacing lymph node architecture) Following image of Follicular lymphoma showing centroblast and centrocyte DLBCL, Burkitt lymphoma and lymphoblastic lymphoma are all high-grade NHLs.", 'role': 'assistant'}]