This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunomodulator, Subject name: Pharmacology
[{'content': 'Etanercept used in rheumatoid arthritis acts by \nSelect and explain. \nA. Inhibition of COX2 and COX-3, B. Inhibition of TNFa, C. Potent immunosuppresent action, D. Auto immunologically mediated action', 'role': 'user'}, {'content': 'Answer: B \nExplanation: i.e. (Inhibition of TNFa): (203-205-KDT 6th) (803-CMDT-l1)Soluble TNF-aR (etanercept) and IL-1 receptor antagonist act to inhibit the activity of pathogenic cytokines in rheumatoid arthritis i.e. TNF-a and IL-1TNFa inhibitors - Etanercept, Infliximab, Adalimumab, golimumab, and certolizumab pegol - A pro inflammatory cytokines - are fulfilling the aim of target therapy for rheumatoid arthritisAbatacept is a costimulation - modulator that inhibits the activation of T-cells*** (629-Katzung 11th)', 'role': 'assistant'}]