This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': "True statement regarding Hirschsprung's disease – \nSelect and explain. \nA. Giant ganglia are present, B. Mucosa is involved and show foldings, C. Manometry excludes the disease, D. Rectal biopsy is contraindicated in infants", 'role': 'user'}, {'content': "Answer: C \nExplanation: Anorectal manometry is a useful screening procedure for the diagnosis of Hirschsprung's disease. A normal response in course of manometric evaluation precludes diagnosis of Hirschsprung's disease.\nHowever the confirmation of diagnosis in case of Hirschsprung's disease is done by rectal biopsy.", 'role': 'assistant'}]