This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
[{'content': 'Which one of the following inherited disorders produce thrombosis \nSelect and explain. \nA. Factor v leden mutation, B. Antithrombin deficiency, C. Homocysteinemia, D. Protein s deficiency p', 'role': 'user'}, {'content': 'Answer: C \nExplanation: ref Robbins 7/e p 131, 8/e p122 , Harrison 18/e p462,9/e p123 Homocysteine (Hcy) is a sulfhydryl amino acid derived from the metabolic conversion of methionine, which is dependent on vitamins (folic acid, B12 and B6) as cofactors or cosubstrates. Severe hyperhomocysteinemia (homocystinuria), due to inherited metabolic defects of Hcy metabolism, is associated with very high risk of venous thromboembolism (VTE); treatment with vitamins is associated with dramatic decrease of VTE risk', 'role': 'assistant'}]