This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Growth and development, Subject name: Pediatrics
[{'content': 'Early epiphyseal closure is seen with _________ \nSelect and explain. \nA. LH, B. FSH, C. Estrogen, D. Progesterone', 'role': 'user'}, {'content': 'Answer: C \nExplanation: The growth velocity decreases and may even be zero after epiphyseal fusion, that is, after growth plate closure in late pubey. Precocious pubey (PP) is a known cause of sho stature after earlier pubey due to premature closure of growth plates in long bones Precocious pubey may be due to increased estrogen . Ref : Nelson paediatrics Chapter : Growth and deve', 'role': 'assistant'}]