This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Asthma, Subject name: Pharmacology
[{'content': 'Inhibition of 5- lipoxygenase is useful in: \nSelect and explain. \nA. cardiac failure, B. bronchial asthma, C. hepatic failure, D. arthritis', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e. Bronchial Asthma 5 Lioxygenase acts on Arachidonic acid to release leukotrienes which are important inflammatory mediators. They are responsible for the bronchospasm during asthma attack.So as obvious any drug which inhibits 5 lipoxygenase will prevent the formation of Leukotrienes and will be useful in the t/t of Asthma.Zileuton* is a 5 lipoxygenase inhibitor which is being currently used in USA. It is a bronchodilator that reduces asthma morbidity and is effective in exercise induced asthma.", 'role': 'assistant'}]