This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: CHF, Angina Pectoris and Myocardial Infarction, Subject name: Pharmacology
[{'content': 'Which of the following drug is associated with highest cardiac moality? \nSelect and explain. \nA. Rofecoxib, B. Nicorandil, C. Losaan, D. Metoprolol', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Rofecoxib is a selective COX-2 inhibitor that was withdrawn due to increased risk of MI. ARBs (losaan) and b blockers (metoprolol) are cardioprotective in CHF. These decrease the moality. Nicorandil is a K+ channel opener used in angina. It is cardioprotective by causing ischemic pre-conditioning.', 'role': 'assistant'}]