This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NEET Jan 2020, Subject name: Pathology
[{'content': 'A boy after playing football complaining fatigue and abdominal pain. He also had a history of hand swelling in past. On ultrasonography, he has shrunken spleen. What is the likely diagnosis of this patient? \nSelect and explain. \nA. Sickle cell anemia, B. Iron deficiency anemia, C. Acute pancreatitis, D. Intermittent porphyria', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Sickle cell anemia b-globin hemoglobinopathy(mutation in coding sequence ofb-globin gene, GAG - GTG ) Anemia and reticulocytotic;sickle-shaped erythrocytesdemonstrable on peripheral blood smear; homozygosity forhemoglobin Sdemonstrable by electrophoresis Characterized bysevere anemia, recurrent painful and aplastic crises, and nonhealing leg ulcers; recurrent splenic infarcts with progressive fibrosisresult inauto splenectomy', 'role': 'assistant'}]