This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
[{'content': 'Which of the following bacteria cause the intracellular accumulation of high levels of C -AMP? \nSelect and explain. \nA. Vibrio cholera, B. Staphyloccus aureus, C. L-coh heat stable, D. Salmonella', 'role': 'user'}, {'content': 'Answer: A \nExplanation: After reaching small bowel vibrio cholerae produces cholera toxin, which consists of A and B subunit. The B subunit binds to GM1 ganglioside, making possible the delivery of the A subunit to its cytosolic target. The ultimate result is the prolonged activation of C-AMP resulting in intracellular accumulation of high levels of cyclic AMP. Ref: Textbook of Microbiology & Immunology, Parija, 2009 Edition, Page 310 & 311;Textbook of Microbiology, Ananthanarayan and Paniker, 7th Edition, Page 310;Harrisons Principles of Internal Medicine, 16th Edition, Page 910.', 'role': 'assistant'}]