This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General physiology, Subject name: Physiology
[{'content': 'Fever associated with infection \nSelect and explain. \nA. Accelerates bacterial and viral replication, B. Left shifts the oxygen dissociation curve, C. Is due to interleukin-1 released from CD4 T-helper cells, D. Increase oxygen release to tissue', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Fever right shifts the oxygen dissociation curve, which allows for a greater release of oxygen to the tissue, making oxygen easily available to neutrophils and monocytes for use in the oxygen-dependent myeloperoxidase system of bactericidal killing. Having more oxygen available to tissue also enhances wound healing. In addition, fever interferes with bacterial and viral replication by providing a hostile environment for incubation. Fever is produced by the release of interleukin-I from macrophages. Interleukin-I, in turn, stimulates the hypothalamus to synthesize prostaglandins, which interact with the thermoregulatory center to produce fever.', 'role': 'assistant'}]