This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'True about Sickle cell disease are all, Except: \nSelect and explain. \nA. Single nucleotide change results in change of Glutamine to Valine, B. Sticky patch is generated as a result of replacement of a non polar residue with a polar residue, C. HbS confers resistance against malaria in heterozygotes, D. RFLP results from a single base change', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Sticky patch is generated as a result of replacement of a non polar residue with a polar residue Repeat from May 11 Sticky patch in sickle cell disease results from replacement of a polar residue (Glutamate) with a non polar residue Glutamate is ----Polar (Mnemonic: GP i.e. General Practioner) Valine is Non Polar (Valine) at the 6th position of the beta chain.', 'role': 'assistant'}]