This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pharmacology, Subject name: Pharmacology
[{'content': 'Loading drug of dose primaraly depends on \nSelect and explain. \nA. Volume of distribution, B. Clearance, C. Rate of administration, D. Half life', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Loading dose; This is a single or few quickly repeated doses given in the beginning to attain target concentration rapidly. Loading dose =Target Cp * V /F Cp-concentration, V - the volume of distribution, F-oral bioavailabilityThus, the loading dose is governed only by V and not by Clearance or t1/2 Ref ; KD Tripathi Pharmacology 7th edition (page no;33)', 'role': 'assistant'}]