This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.V.S., Subject name: Pediatrics
[{'content': 'Autosplenectomy occurs in: \nSelect and explain. \nA. Thalassemia, B. Sickle cell anemia, C. HbH disease, D. Hydrops fetalis', 'role': 'user'}, {'content': "Answer: B \nExplanation: b. Sickle cell anemia(Ref: Nelson's 20/e p 2336, Ghai 8/e p 345)Patients of sickle cell anemia may undergo auto-splenectomyQ due to multiple infarcts in splenic artery, that causes spleen to be reduced to fibrous tissue (splenic atrophy spleen may become non-palpable).", 'role': 'assistant'}]