This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Heart, Circulation, and Blood, Subject name: Physiology
[{'content': 'All of the following statements are false about stroke volume EXCEPT: \nSelect and explain. \nA. Determined by after load, B. Determined by pre-diastolic volume, C. Decreases by increase in heart rate, D. Increased by increase in heart rate', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ans. C Decreases by increase in heart rateRef: Ganong, 25th ed. pg. 570-71* Basically it is asking here about the TRUE statement among the given choices.* Stroke volume is indirectly proportional to heart rate* Stroke volume = cardiac output/heart rate* As the heart rate increases, stroke volume decreases.* After load is determined by peripheral resistance. Therefore, it has nothing to do with stroke volume determination.* Stroke volume depends upon end diastolic volume (NOT pre-diastolic volume)', 'role': 'assistant'}]