This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'Activity of which of the following enzyme is NOT affected by insulin: \nSelect and explain. \nA. Pyruvate kinase, B. Glycogen synthase, C. Hexokinase, D. Glucokinase', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Hexokinase\n\nTransfer Phosphate group from ATP to Glucose.\nHas high affinity for glucose (Or Lower Km) and not affected by insulin.\nMg2+\xa0is the cofactor.\nIrreversible step.\nATP is utilized.\n\nGlucokinase\n\nPresent in Liver and Pancreatic β cells.\nHas low affinity for Glucose. (High Km).\nHence acts only when blood glucose is very high\xa0 (> 100 mg/dl).\nInduced by Insulin following a meal.\nPlay\xa0 an\xa0 important\xa0 role\xa0 in\xa0 regulation\xa0 of\xa0 blood glucose.\nIn the liver, function of Glucokinase is to remove glucose from portal vein following a meal\nIn the beta cells of Pancreas, function of Glucokinase is to release Insulin.\xa0\n\nGlycogen Synthase\nInsulin favor Glycogenesis by dephosphorylating, Glycogen Synthase.\nKey concept:', 'role': 'assistant'}]