This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Which gene is mutated in Cowden syndrome? \nSelect and explain. \nA. SMAD 2, B. PTCH, C. PTEN, D. APC', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Cowden syndrome is also known as multiple hamartoma - neoplasia syndrome.\nIt is due to PTEN gene mutation. It increases the risk of Ca Breast, Ca endometrium and thyroid cancers.', 'role': 'assistant'}]