This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous (Pharmacology), Subject name: Pharmacology
[{'content': 'Contraindication for the triptans is which of the following? \nSelect and explain. \nA. Ischemic heart disease, B. Epilepsy, C. Hepatic failure, D. All of the above', 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans. is 'd' i.e., All of the above Triptans* These are 5-HT1D/1B receptor agonists.* Sumatriptan is the 1st triptan to be developed. It is the drug of choice for aborting an acute attack of migraine.* Other triptans in clinical use are Almotriptan, eletriptan,frovatriptan, rizatriptan, eletriptan, naratriptan, and zolmitriptan.* All triptans can cause coronary vasospasm and are contraindiated in IHD. Other contraindications are hypertension, epilepsy, hepatic or renal impairment and during pregnancy.* The most important adverse effects are feeling of chest pressure, tightness and pain which may he accompanied by arrhythmia and MI and appear to be due to coronary vasospasm.", 'role': 'assistant'}]