This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Vesiculobullous (Blistering) Disorders, Subject name: Skin
[{'content': 'Acantholysis is due to destruction of : \nSelect and explain. \nA. Epidermis, B. Subepidermis, C. Intercellular substance, D. Basement membrane', 'role': 'user'}, {'content': "Answer: C \nExplanation: Ans. is 'c' Intercellular Substance It is loss of cohesion b/w epidermal cells due to destruction of intercellulare substance. IgG Antibodies are formed against the intercellular substance.Acantholysis occurs in stratum Basale in Pemiphus Vulgaris*Acantholysis is demonstrated by Nikolsky's sign*Acantholytic cells are demonstrated by Tzanck smear*", 'role': 'assistant'}]