This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Neoplastic Agents, Subject name: Pharmacology
[{'content': 'Which of the following anti neoplastic drug causes hepatotoxicity: \nSelect and explain. \nA. 6- mercaptopurine, B. 5- flurouracil, C. Doxorubicin, D. Etoposide', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. (a) 6- mercaptopurineRef.: KDT 6th ed. / 820* 6 mercaptopurine (6-MP) is a purine analogue which is metabolized by xanthine oxidase* It is a competitive inhibitor of DNA.* Allopurinol is NOT given along with 6-MP because allopurinol inhibits xanthine oxidase enzyme, which leads to increased toxicity due to accumulation of xanthine.Anti-Neoplastic DrugsTheir Side EffectCyclophosphamide, ifosphamideHemorrhagic cystitisProcarbazineDisulfiram like reactionBleomycin, busulfanPulmonary fibrosisVincristine, vinblastinePeripheral neuropathyCisplatinOtotoxicity, Nephrotoxicity6Mercaptopurine, 6ThioguanineHepatotoxicityDoxorubicin, DaunorubicinCardiotoxic', 'role': 'assistant'}]