This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous (Obs), Subject name: Gynaecology & Obstetrics
[{'content': 'Child with history of Rh incompatibility is brought to OPD with jaundice, irritability and convulsions most common cause \nSelect and explain. \nA. Kemicterus, B. Physiological jaundice, C. Hyperpyraxia, D. Meningitis', 'role': 'user'}, {'content': 'Answer: A \nExplanation: (A) Kernicterus # Kernicterus is the pathological findings of bilirubin (un-conjugated) toxicity within the brain.> The main transporter of bilirubin is albumin therefore increase in albumin causes less bilirubin to be transported to the brain> This includes staining & necrosis of neurons in the basal ganglia, hippocampal cortex, subthalamic nuclei and cerebellum followed by gliosis of these areas.> The cerebral cortex is generally spared, but 50% of babies have extra neuronal lesions with necrosis of renal tubular cells, intestinal mucosa and pancreatic cells.> These may manifest as gastrointestinal hemorrhage or hematuria.> Clinically, kernicterus is described in phases, which may progress over 24 hours to 7 days', 'role': 'assistant'}]