This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Which of the following diuretics acts on nephron through interstitium \nSelect and explain. \nA. Thiazide, B. Furosemide, C. Acetazolamide, D. Spironolactone', 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans. is 'd' i.e., Spironolactone(Ref: KDT Vh/e p. 587)Spironolactone is mineralocoicoid (aldosterone) antagonist. It opposes the action of Aldosterone without requiring access to the tubular lumen.Spirinolactone (as well as aldosterone) act from the interstitial side.", 'role': 'assistant'}]