This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Pharmacology
[{'content': 'All the following are true of the active site of enzymes, except \nSelect and explain. \nA. Shape is not rigid, B. Are preserved even after denaturation, C. Bind the substrate with non-covalent bonds, D. Amino acids at the active site paicipate in catalysis', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Active site is a 3D cleft formed by groups that come from different pas of amino acid sequence. 2 PAS: CATALYTIC SITE and BINDING SITE Active sites are clefts 3Dimensional Site is contributed by Amino acids far apa in the enzyme Amino acids are arranged precisely-only specific substrate can bind. Serine, His, asp, glu, cys make up the active site Substrates are bound to enzymes by multiple weak attraction Ref: KD Tripathi 8th ed.', 'role': 'assistant'}]