This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
[{'content': 'True about immune response of hepatitis B is: \nSelect and explain. \nA. Antibody of HBsAg is associated with resistance to infection, B. Antibody to HBc is not protective, C. Highest titres of anti-HBc are found in persistent carriers of HBsAg, D. CMI disappears soon after recover', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Hepatitis B virus natural infection induces lifelong immunity.\nThe immunity is primarily mediated by humoral antibodies against HBsAg. Antibodies to HBsAg are protective.\xa0\nThese antibodies bind to surface antigens or with the virus and prevent it from interacting with receptors on the hepatocytes.\nThese antibodies appear to neutralize the infectivity of HBV.\n\n\u200bParija SC. Textbook of Microbiology & Immunology. Elsevier Health Sciences; 2014. Page:552', 'role': 'assistant'}]