This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: JIPMER 2018, Subject name: Biochemistry
[{'content': 'Which of the following decreases affinity of oxygen with hemoglobin? \nSelect and explain. \nA. Decreased H+ ions, B. 2,3 BPG, C. Decrease in temperature, D. Decreased sorbitol', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Decrease affinity of oxygen with hemoglobin-Oxygen hemoglobin curve shift to right -increaseddelivery of oxygen to the tissue Increase affinity of oxygen with hemoglobin -Oxygen hemoglobin curve shift to left- Increased delivery of oxygen to the HEMOGLOBIN in lungs Factors increase hydrogen ions (acidosis ) Increase CO2 Increase in temperature Increase in 2,3 DPG Exercise Pregnancy High altitude Hemoglobin S Factors decrease hydrogen ion (alkalosis ) Decrease CO2 Decrease in temperature Fetal hemoglobin Methemoglobinemia 2,3-Bisphosphoglycerate also known as 2,3-Disphosphoglycerate (2,3 BPG or 2,3-DPG) is the most abundant organic phosphate in the erythrocyte. 2,3-BPG is produced in the erythrocytes from an intermediate (1,3-bisphosphoglycerate) of glycolysis. This sho pathway is referred to as Rapapo-Leubering cycle.', 'role': 'assistant'}]