This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NEET 2018, Subject name: Biochemistry
[{'content': 'The enzyme deficient in Lysch Nyhan syndrome is:- \nSelect and explain. \nA. Adenosine Deaminase, B. PRPP synthetase, C. HGPase, D. Xanthine oxidase', 'role': 'user'}, {'content': 'Answer: C \nExplanation: HGPase (Hypoxanthine guanine phosphoribosyl transferase) deficiency: Causes Lesch-Nyhan syndrome. | synthesis of purine nucleotides |utilization of purines (hypoxanthine and guanine) by salvage pathway-accumulation of PRPP (Neurotoxic component)- Self mutilation Defect in salvage pathway- | IMP and CMP - impairment feedback regulation of their production', 'role': 'assistant'}]