This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Antibiotics, Subject name: Pharmacology
[{'content': 'Which of the following antifungal agents binds to ergosterol \nSelect and explain. \nA. Flucytosine, B. Terbinafine, C. Amphotericin B, D. Fluconazole', 'role': 'user'}, {'content': "Answer: C \nExplanation: POLYENE ANTIBIOTICS Amphotericin B (AMB) Mech of action:- The polyenes have high affinity for ergosterol present in fungal cell membrane. They combine with it, get inseed into the membrane and several polyene molecules together orient themselves in such a way as to form a 'micropore'. The hydrophilic side forms the interior of the pore through which ions, amino acids and other water-soluble substances move out. The micropore is stabilized by membrane sterols which fill up the spaces between the AMB molecules on the lipophilic side--constituting the outer surface of the pore. Thus, cell permeability is markedly increased. Ref:- kd tripathi; pg num:-787", 'role': 'assistant'}]