This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
[{'content': 'Testing of HLA-B*57:01 is recommended prior to the initiation of this anti-retroviral agent \nSelect and explain. \nA. Atazanavir, B. Nelfinavir, C. Raltegravir, D. Abacavir', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ref. KDT. Page.\xa0 808\nAbacavir\n\nIt is a potent ARV drug that acts after intracellular conversion to carbovir triphosphate.\nResistance to ABC develops slowly\nIts oral bioavailability is 80% and it is mainly eliminated by metabolism.\nThe plasma t1⁄2 is 1–1.5 hour, but intracellular t1⁄2 of active metabolite is >12 hours.\nHypersensitivity reactions such as rashes, fever, flu-like symptoms are the major problems.\nTo avoid anaphylactic reactions in response to the drug HLA-B*57:01 \xa0testing is mandatory pre-treatment. \nAvoidance of alcohol is advised.', 'role': 'assistant'}]