This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Increased permeability in acute inflammation is due to? \nSelect and explain. \nA. Histamine, B. IL-2, C. TGF-(3, D. FGF', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Histamine Formation of endothelial gaps in venules, i.e. immediate transient response is the most common mechanism causing increased vascular permeability in acute inflammation. Mediators involved in this mechanism are :- Immediate (more impoant) : Histamine, bradykinin, leukotrienes, neuropeptide substance P. Somewhat delayed: IL-1, TNF, IFN-y", 'role': 'assistant'}]