This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Dose of digoxin is NOT altered in ? \nSelect and explain. \nA. Old age, B. Hepatic disease, C. Renal disease, D. Hypercalcemia', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e., Hepatic disease o Make it clear once and for all that Digitalis is the parent compound. Digitalis is applied as a collective term for the whole group and has come to mean a cardiac glycoside. o Digoxin and digitoxin are two of the many types of cardiac glycoside. o Digoxin is a polar glycoside, and is excreted by kidney, does not undergo hepatic metabolism. So dose need not be altered in hepatic disease. o Digitoxin undergoes hepatic metabolism and its dose has to be altered in hepatic disease.", 'role': 'assistant'}]