This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous (Pharmacology), Subject name: Pharmacology
[{'content': 'Which of the following NSAID has good tissue penetrability with concentration in synovial fluid \nSelect and explain. \nA. Ketorolac, B. Diclphenac sodium, C. Sulindac, D. Piroxicam', 'role': 'user'}, {'content': 'Answer: B \nExplanation: (Diclofenac sodium) (178 - KDT) (193-KDT 6th)* DICLOFENAC - SODIUM - Well absorbed orally 99% protein bound, metabolized and excreted both in urine and bile However it has good tissue penetrability and concentration in synovial fluid is maintained for 3 times long period than in plasma, exerting extended therapeutic action in joints* PIROXICAM - It is reversible inhibitor of COX, lowers PG concentration in synovial fluid and inhibits platelet aggregation prolonging bleedmg time* KETOROLAC - It is highly plasma protein bound and 6% excreted unchanged in urine major metabolic pathway is glucoronidation* SULINDAC - At lower doses is a selective extrarenal PG synthesis inhibitor - does not antagonize the diuretic and anti hypertensive action of thiazides, P blockers and ACE inhibitors or alter renal functions', 'role': 'assistant'}]