This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'In anoxia of liver, necrosis is seen in -a) Centrilobularb) Around the peripheryc) Around the central veind) Around the bile duct \nSelect and explain. \nA. ac, B. bc, C. ad, D. b', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Architecture of liver lobule\n\nLiver is divided into hexagonal lobules oriented around the terminal tributaries of the hepatic vein (Terminal hepatic veins), i.e. Terminal hepatic vein is in the centre of the lobule and area around the hepatic vein is called centrilobular zone.\nAt peripheri of lobule, lies the portal tract containing hepatic artery, bile duct and portal vein. Area around portal tract is called periportal zone.\nArea between periportal zone and centrilobular zone is called midzonal area.\nSo, the blood supply (hepatic artery & portal vein) comes from the peripheral part of the lobule → thus periportal area is nearest to the blood supply and least susceptible to ischemic necrosis, on the other hand centrilobular area is farthest from blood supply and is most susceptible to ischemic necrosis.\n\nFollowing information have been added in 8th/e of Robbins \n\nAcute liver failure is defined as an acute liver illness that is associated with encephalopathy within 6 months after the initial diagnosis.\nFulminant liver failure → when encephalopathy develops rapidly, within 2 weeks of the onset of jaundice.\nSubfulminant liver failure → when encephalopathy develops within 3 months of onset of jaundice.', 'role': 'assistant'}]