This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'Subtelomeric rearrangement of genes is frequently associated wih mental retardation. All of the following techniques can be used to diagnose them except: \nSelect and explain. \nA. FISH, B. MAPH, C. cGH array, D. MALDI', 'role': 'user'}, {'content': 'Answer: D \nExplanation: D i.e. MALDISubtelomeric rearrangements of gene eg chromosomal duplications or deletions too small to be detected by conventional cytogentic analysis are detected by c-GH (comparative genomic hybridization), multiprobe FISH (fluorescence in situ hybridization), MAPH (multiplex amplifable probe hybridization) and MLPA (multiplex ligation-dependent probe amplification). Subtelomeric rearrangements are significant cause of idiopathic & familial mental retardation.', 'role': 'assistant'}]