This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': "Sickling in 'HbS' disease is primarily caused by \nSelect and explain. \nA. Decreased Solubility, B. Decreased Stability, C. Altered function, D. Altered 02 binding capacity", 'role': 'user'}, {'content': 'Answer: A \nExplanation: A i.e. Decreased Solubility', 'role': 'assistant'}]