This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Drug effective for most trematodes and many cestodes- \nSelect and explain. \nA. Praziquental, B. Pirenzipine, C. Niclosamids, D. Pyrantel palmoate', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Praziquantal Praziquental o Praziquantal is the DOC for treatment of all trematodes and cestodes except for fasciola hepatica (DOC bithionol) and hydatid disease (DOC albendazole), Neurocysticercosis (DOC is albendazole). o It acts by causing leakage of intracellular calcium from the membrane --9 contracture & paralysis. o At relatively higher concentrations, it causes vacuolization of the tegument and release of the contents of tapeworms and flukes followed by their destruction by the host -3 this action appear to be more impoant in case of schistosomes and flukes. o Despite systemic absorption praziquantel exhibits no systemic toxicity.", 'role': 'assistant'}]