This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Fungal Drugs, Subject name: Pharmacology
[{'content': 'Which of the following statements about fluconazole is most accurate? \nSelect and explain. \nA. It is highly effective in the treatment of aspergillosis, B. It does not penetrate the blood-brain barrier, C. Its oral bioavailability is less than that of ketoconazole, D. It inhibits demethylation of lanosterol', 'role': 'user'}, {'content': 'Answer: D \nExplanation: * Fluconazole (Azoles) act by inhibiting the enzyme lanosterol-14-a-demethylase resulting in reduced ergosterol synthesis. * It has very good CNS penetration and oral bioavailability. * It is not very effective against aspergillosis (voriconazole is the drug of choice).', 'role': 'assistant'}]