This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'Nude mouse is used in genetics because of the following properties -a) Absence of thymusb) Xenograft can be sustained for weeksc) Severe combined immunodeficiency mice is same as nude miced) they can generate mature\xa0T lymphocytes \nSelect and explain. \nA. ac, B. ab, C. ad, D. bc', 'role': 'user'}, {'content': 'Answer: B \nExplanation: The genetic basis of nude mouse mutation is a disruption of the FOXN1 gene.\nCharacteristics of nude mouse mutation are:-\n\n\nAR mutation of a nu locus on chromosome 11\n\n\nThymic aplasia\n\n\nT-cell deficient\nNormal B-cell function.\nPhenotypically hairless.\nAccepts xenograft and allograft transplantation\nInsusceptible to graft-versus-host disease\nNo generation of cytotoxic effector cells\n\n\nSCID mutation occurs on chromosome 16. SCID mouse has a thymus, lymph nodes and splenic follicles virtually devoid of lymphocytes.', 'role': 'assistant'}]