This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Pharmacology
[{'content': 'Sirolimus is more likely than cyclosporine to cause: \nSelect and explain. \nA. Hypeension, B. Osteoporosis, C. Renal insufficiency, D. Thrombocytopenia', 'role': 'user'}, {'content': 'Answer: D \nExplanation: (Ref: KDT 6/e p840) Cyclosporine and tacrolimus cause nephrotoxicity as an adverse effect. Sirolimus (rapamycin) results in bone marrow suppression and thus may cause anemia, thrombocytopenia and leukopenia.', 'role': 'assistant'}]