This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'Increase acetylcholinestrase in amniotic fluid indicates - \nSelect and explain. \nA. Open neural tube defects, B. Oesophageal atresia, C. Down syndrome, D. Edward syndrome', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Open Neural Tube Defect Prenatal diagnosis of neural tube defect In intra embryonic life, neural tube is open at both end and freely communicate with amniotic cavity. Failure of closure of neural tube results in persistant of this communication. o This allows excretion of following fetal substances into amniotic cavity ? 1) Alpha - fetoprotein 2) Acetykholinesterase o These serve as biochemical marmkers for NTDs for prenatal diagnosis.", 'role': 'assistant'}]