This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cardiovascular system, Subject name: Pharmacology
[{'content': 'Which of the following drug is associated with the highest cardiac moality? \nSelect and explain. \nA. Rofecoxib, B. Nicorandil, C. Losaan, D. Metoprolol', 'role': 'user'}, {'content': "Answer: A \nExplanation: Coxibs are selective cox2 inhibitors- Basically, Coxibs are NSAIDS They won't cause gastric acidity as they won't exe their effect on cox-1 but as there is an increased chance of cardiac events like hea attack due to excess thrombosis Excess thrombosis is due to decrease in PGI2 and enhanced TXA2 Ref: KD Tripathi 8th ed.", 'role': 'assistant'}]