This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Anatomy
[{'content': 'Which antihypeensive is a prodrug and is coveed to its active form in brain? \nSelect and explain. \nA. Clonidine, B. Methyldopa, C. Minoxidil, D. Nitroprusside', 'role': 'user'}, {'content': 'Answer: B \nExplanation: (Ref: KDT 6/e p547) Although both methyldopa and minoxidil are produrgs, conversion of methyldopa to a-methylnorepinephrine takes place in the brain whereas minoxidil is activated to minoxidil sulphate (by phase II reaction) in the periphery.', 'role': 'assistant'}]