This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
[{'content': 'Proteasome inhibition is seen with \nSelect and explain. \nA. Fludarabine, B. Thioguanine, C. Boezomib, D. Rivaroxiban', 'role': 'user'}, {'content': 'Answer: C \nExplanation: It is a proteasome inhibitor - an anticancer drugBoezomib was first approved for use in relapsing or refractory multiple myeloma and is now widely used in the first-line treatment of multiple myeloma. This agent is thought to exe its main cytotoxic effects through inhibition of the 26 S proteasome, which results in down-regulation of the nuclear factor kappa B (NF-kB) signaling pathway. Of note,inhibition of NF-kB has been shown to restore chemosensitivity.Ref: Sharma and Sharma 3rd ed/pg 871; Katzung; 13th edition; Page no: 971', 'role': 'assistant'}]