This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pharmacokinetics, Subject name: Pharmacology
[{'content': 'Which of the following is a Phase I reaction in Xenobiotics? \nSelect and explain. \nA. Hvdroxylation, B. Methylation, C. Conjugation, D. Acetylation', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ref: Basic and clinical Pharmacology by Bel ram Katzung, 12th edition Pp-56,57,60Explanation:Phase I reactions are Oxidation, reduction andhydrolysisThis includes CYP dependent oxidation, dealklation, deamination, desulfation, dechlorination.CYP independent oxidations like Flav in monooxygenase. amine oxidases, dehydrogenationsReduction includes azo reductions, nitroredu- ctionsHydrolysis includes ester and amidePhase II reactions are Conjugation (glucuronida- tion, glycine,glutathione), methylation Sulfation and acetylation', 'role': 'assistant'}]