This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'All are impoant pathological features noted in ATP 7B gene mutation, EXCEPT: \nSelect and explain. \nA. Low serum ceruloplasmin, B. Low serum free copper, C. Low serum copper, D. Positive copper balance', 'role': 'user'}, {'content': 'Answer: B \nExplanation: ATP7B protein deficiency impairs Biliary copper excretion resulting in positive copper balance Hepatic copper accumulation Copper toxicity from oxidant damage It leads to low serum ceruloplasmin due to excess catabolism of apoceruloplasmin. Low serum copper is due to low ceruloplasmin level. Non ceruloplasmin bound copper level will be high-free copper. Ref: Harrison, E-18, P-3188.', 'role': 'assistant'}]