This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Causes of restrictive cardiomyopathy are-a) amyloidb) sarcoidosisc) Viral myopathyd) Alcohole) Storage disease \nSelect and explain. \nA. abe, B. bcd, C. cde, D. acd', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Acute viral myocarditis, alcohol abuse, pregnancy., thyroid disease, cocaine use, and chronic uncontrolled\xa0tachycardia cause dilated cardiomyopathy- Harrison 17th/l481\nRestrictive Cardiomyopathies (RCMs) - Harrison 17th/1485-86\n\nThe hallmark ofthe restrictive cardiomyopathies (RCMs) is abnormal diastolic function ; the ventricular\xa0wails are excessively rigid and impede ventricular filling. In late stages systolic function is also impaired.\nMyocardial fibrosis- livpertropby. or infiltration due to a variety of causes is responsible. Myocardial\xa0involvement with amyloid1 is a common cause of secondary restrictive cardiomyopathy although\xa0restriction is also seen in the transplanted heart, in hemochromatosis, glycogen depositiong,\xa0endomyocardial fibrosis, sarcoidosis , hypereosinopbillc disease., and scleroderma; following mediastinal\xa0irradiation; and in neoplastic infiltration and myocardial fibrosis of diverse causes.\nIn many of these conditions, particularly those with substantial concomitant endocardial involvement,\xa0partial obliteration of the ventricular cavity by fibrous tissue and thrombus contributes to the abnormally\xa0increased resistance to ventricular filling.\nThromboembolic complications are frequent in such patients\nThe inability" of the ventricles to fill limits cardiac output and raises filling pressures; thus, exercise\xa0intolerance and dyspnea are usually prominent. As a result of persistently elevated systemic venous\xa0pressure, these patients commonly have dependent edema, ascites, and an enlarged, tender, and often\xa0pulsatile liver .\nThe jugular venous pressure is elevated and does not fall normally (or may rise) with inspiration\xa0(KussmauTssignf', 'role': 'assistant'}]