This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chronic Inflammation, Subject name: Pathology
[{'content': 'Which inflammatory marker is responsible for appetite suppression and lipid depletion culminating to muscle atrophy in case of inadequate nutrition: \nSelect and explain. \nA. TNF, B. TGF beta, C. EGF, D. FGF', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Cachexia is also seen in patients with chronic inflammatory diseases and cancer. In the former, chronic overproduction of the inflammatory cytokine tumor necrosis factor (TNF) is thought to be responsible for appetite suppression and lipid depletion, culminating in muscle atrophy.', 'role': 'assistant'}]