This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anatomy of skin, Subject name: Dental
[{'content': 'A young person is having comedones and papulopustular acne over face and trunk and back. How will you manage the patient ? \nSelect and explain. \nA. Topical retinoic acid, B. Oral doxycycline + topical retinoic acid, C. Topical clindamycin, D. Oral retinoic acid', 'role': 'user'}, {'content': 'Answer: B \nExplanation: systemic antibiotics are mainstay in the Rx of acne vulgaris. Tetracycline group is commonly prescribed of which more lipophilic antibiotics like doxycycline and minocycline are more effective. Topical Retinoids are comedolytic and anti inflammatory. They act by restoring the altered follicular keratinisation. Grade 1 acne - comedones, occasional papules Grade 2 acne - papules, comedones, few pustules Grade 3 acne - predominant pustules, nodules, abscesses Grade 4 acne- mainly pseudocysts, abscesses, widespread scarring Rx Grade 1- topical retinoids Grade 2 - depending on the type of predominant lesions present, combined use of topical benzyl peroxidase, retinoids, and antibacterials Grade 3- oral antibiotics Grade 4- oral retinoids,isotretinoin Reference Harrison20th edition pg 1208', 'role': 'assistant'}]