This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Causes for less bioavailability - \nSelect and explain. \nA. High first pass metabolism, B. Increased absorption, C. IV drug administration, D. High solubility', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., High first pass metabolism o Causes for less bioavailability. Incomplete absorption o High first pass metabolism. About other options Increased absorption increases bioavailability. o I.V. administration has 100% bioavailahi I ity. High lipid solubility causes more absorption and better bioavailability.", 'role': 'assistant'}]