This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pathology
[{'content': 'Which of the following is the most common cause of insulin resistance? \nSelect and explain. \nA. Obesity, B. Post receptor defects, C. Liver dysfunction, D. Pancreatic dysfunction', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Obesity is probably the most common cause for insulin resistance. The risk for diabetes increases with BMI . It is not only the absolute amount but also the distribution of body fat that has an effect on insulin sensitivity. Central obesity(Abdoominal fat) is more likely to be linked than peripheral( gluteal fat). Obesity impacts in different ways through Free Fatty Acids , Adipokines etc.', 'role': 'assistant'}]