This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunomodulator, Subject name: Pharmacology
[{'content': 'What is mechanism of action of colchicine in acute gout? \nSelect and explain. \nA. Inhibition of leukotriene B4, B. Inhibition of release of chemotactic factors, C. Binding to tubulin and inhibition of leucocyte migration, D. Promotes metabolism of urate crystal', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ans. c. Binding to tubulin and inhibition of leucocyte migrationRef: Goodman Gilman 12th e/P 995Colchicine inhibits tubulins required for mobilization of leucocytes (neutrophils) in to joints in an acute attack of gout.It also inhibits release of chemotactic factors form neutrophils and inhibits adhesion of neutrophils to endothelium of blood vessels.', 'role': 'assistant'}]