This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Blood, Subject name: Medicine
[{'content': 'In Beta thalassemia, the most common gene mutation is: \nSelect and explain. \nA. Intron 1 inversion, B. Intron 22, C. 619 bp deletion, D. 3.7 bp deletion', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Intron 1 inversion The most common mutation causing a thalassemia is intronfinversionThalassemias are autosomal recessive disorder.The most common mutation causing thalassemias is intron/inversionAlso know:o Synthesis of alpha chain is controlled by 2 gene clusters on - Chromosome 16o Synthesis of beta chain is controlled by 2 gene clusters on - Chromosome 11Thalassemia mutations in IndiaMultationsFrequencyo IVS1-5(G-C)o 619 bp delectiono IVS-I (G-T)o FR41/42(TCTT)o FR8/9 (+G )o CodonlS (G-A)o Others48%18%9%9%5%6%100%", 'role': 'assistant'}]