This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Adverse Drug Effect, Subject name: Pharmacology
[{'content': 'ATT drug causing hyperuricemia: \nSelect and explain. \nA. Isoniazid, B. Pyrazinamide, C. Streptomycin, D. Rifampicin', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Ans. (b) PyrazinamideRef : KDT 6th ed. / 742Pyrazinamidemicrosomal deaminase-----------------pyrazinoic acid(POA)xanthine oxidase---------------5-hydroxypyrazinoic acid* Pyrazinamide is hydrolyzed by microsomal deaminase to pyrazinoic acid (POA) and then hydroxylated to 5-hydroxypyrazinoic acid by xanthine oxidase for excretion by the kidneys.* Pyrazinamide is a first line antitubercular drug that can cause hyperuricemia (secondary to inhibition of uric acid secretion in the kidney) and hepatotoxicity.* This hyperuricemia leads to arthralgia due to competitive inhibition of xanthine oxidase by POA. It should not be stopped if hyperuricemia develops* Ethambutol also produces hyperuricemia due to interferance with urate excretion.', 'role': 'assistant'}]