This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Enzymes, Subject name: Biochemistry
[{'content': "Deficiency of the enzyme phytate oxidase results in? \nSelect and explain. \nA. Zillweger's disease, B. Low's syndrome, C. Refsum's disease, D. Tay-sach's disease", 'role': 'user'}, {'content': "Answer: C \nExplanation: Ans. c (Refsum's disease). (Ref. Harper, Biochemistry, 25th ed., 248)INBORN ERRORFEATURERefsum's diseaseIt is a rare inherited disorder caused by accumulation of phytanic acidIts due to the deficiency of phytate oxidase and defect in alpha oxidation.It basically leads to peripheral neuropathy due to accumulation of phytanic acid in nerves,and retinitis pigmentosa is other associated feature.Zellweger's diseasecerebrohepatorenal syndrome that occurs due to inherited absence of peroxisomes.Lowe's syndromeis occulocerebrorenal syndrome. (Heart is not involved)Tay-sach's diseaseis a sphingolipidosis (Hexosaminidase A is absent)", 'role': 'assistant'}]