This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: JIPMER 2017, Subject name: Pediatrics
[{'content': 'A 6 - year - old boy with lymphoreticular malignancy has come for a cycle of chemotherapy. Which of the following investigatins need to be done for next 4 hours to diagnose tumour lysis syndrome? \nSelect and explain. \nA. Urea, creatinine, chloride, Ca2+ and K+, B. Urea, creatinine, phosphate, Ca2+ and K+, C. Urea, creatinine, magnesium, Ca2+ and K+, D. Urea, creatinine, sodium and phosphate', 'role': 'user'}, {'content': "Answer: B \nExplanation: Tumour lysis syndrome (TLS) - -Uric acid, phosphate and potassium are released in large quantities from death of tumour cells. -Hyperuricemia can lead to impairment of renal function, which fuher exacerbates the metabolic abnormalities. -Hypocalcaemia is a consequence of acute hyperphosphatemia with subsequent precipitation of calcium phosphate in soft tissues. 'TLS can occur before therapy in patients with a large tumour burden (e.g., Burkitt lymphoma, Hyperleukocytosis) It is usually seen within 12-48 hr of initiating chemotherapy.", 'role': 'assistant'}]