This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology and breast, Subject name: Surgery
[{'content': 'Ca breast in females is least related to \nSelect and explain. \nA. BRCA-1, B. BRCA-2, C. Li Fraumeni syndrome, D. Ataxia telangiectasia', 'role': 'user'}, {'content': "Answer: D \nExplanation: Mutation of tumour suppressor genes BRCA1 % BRCA2 is thought to be involved with high risk of breast carcinoma. BRCA1 mutation is having more risk (35-45%) than BRCA2 mutation. BRCA1 is located in the long arm of chromosome 17, whereas BRCA2 is located on the long arm of chromosome13. Li-Fraumen's syndrome(LFS) is autosomal dominant condition with breast cancer inheritance(90%). Breast cancer is also associated with ataxia telangiectasia. But comparing others it is least related to. Reference: SRB's Manual of Surgery, 6th Edition, page no = 522.", 'role': 'assistant'}]