This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
[{'content': 'Which of the following anticancer drugs can cause hypercoagulable state? \nSelect and explain. \nA. 5-FU, B. L-asparaginase, C. Melphalan, D. Carmustine', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Ref: Katzung 11/e p955 L-asparaginase cause the breakdown of asparagine and thus interference with protein synthesis. It can inhibit the production of clotting factors (responsible for cerebal hemorrhage) as well as anti-clotting protiens(can lead to coical viens thrombosis and other hypercoagulable state).', 'role': 'assistant'}]