This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cirrhosis, Subject name: Pathology
[{'content': 'All are true about acetaminophen except: \nSelect and explain. \nA. It is the most commonly used analgesic, B. About 95% of acetaminophen undergoes detoxification by CYP2E1, C. In severe doses liver failure may occur, D. Injury to liver is produced by NAPQI', 'role': 'user'}, {'content': 'Answer: B \nExplanation: At therapeutic doses, about 95% of acetaminophen undergoes detoxification in the liver by phase II enzymes and is excreted in the urine as glucuronate or sulfate conjugates The injury produced by NAPQI (N-acetyl-benzoquinoneimine) involves two mechanisms: Covalent binding to hepatic proteins-Damage to cellular membranes and mitochondrial dysfunction, Depletion of glutathione, making hepatocytes more susceptible to reactive oxygen species-induced injury', 'role': 'assistant'}]