This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Most characteristic features of actual inflammation in- \nSelect and explain. \nA. Vasoconstriction, B. Vascular stasis, C. Vasodilation and increased vascular permeability, D. Margination of leukocytes', 'role': 'user'}, {'content': 'Answer: C \nExplanation: EFFECTS OF VARIOUS MEDIATORS\no Various effects of inflammatory mediators are\n1. Increased vascular permeability Histamine, serotonin (5-hydroxytryptamine), anaphylatoxins (C3a, C4a, C5a), PAF, leukotrienes (LTC4, D4, E4), bradykinin.\n□ PAF is the most potent one to increase permeability.\n2. Chemoattractant\xa0C5a (most potent), IL-8, LTB4, PAF, bacterial products, Lymphokine, Kallikrein.\n□ C5a is the most potent chemoattractant.\n3. Vasodilatation\xa0Histamine, prostaglandins (PG D2, PGE2), prostacyclin\xa0(PGI2), serotonin. Nitric oxide, bradykinin.\n4. Vasoconstriction\xa0Leukotrienes (LTC4, D4, E4), Thromboxane A2.\n5. Bronchoconstriction\xa0Leukotrienes (LTC4, D4, E4), PFA, histamine, bradykinin.\n□ Leukotrienes (LTC4, D4, E4) are the most potent bronchoconstrictors.\n6. Pain Prostaglandins, bradykinin.\n7. Fever (pyrogens) IL-1, TNF-αl IL-6, prostaglandins, interferon.', 'role': 'assistant'}]