This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Glyceryl trinitrate is given by a sublingual route because of: \nSelect and explain. \nA. High hepatic first-pass metabolism., B. High bioavailability., C. Short t- half in plasma., D. Extensive protein binding.', 'role': 'user'}, {'content': 'Answer: A \nExplanation: In the sublingual route, the liver is bypassed and drugs with the high first-pass metabolism are absorbed directly into systemic circulation.', 'role': 'assistant'}]