This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cirrhosis, Subject name: Medicine
[{'content': "All of the following are true about Primary Biliary Cirrhosis except? \nSelect and explain. \nA. Increase 5'- nucleotidase, B. Median age of presentation is 50 years, C. Most common cause of cholangitis in children, D. PBC frequently associated with CREST syndrome", 'role': 'user'}, {'content': "Answer: C \nExplanation: Primary biliary cirrhosis- Characterized by chronic inflammation and fibrous obliteration of intrahepatic bile ductules. Associated with autoimmune disorders- CREST syndrome, Sicca syndrome, Autoimmune thyroiditis, Type-1 Diabetes mellitus and IgA deficiency. Mostly seen in females Age is 35-60 yrs C/F-Pruritis, jaundice, steatorrhoea, xanthelasma, hepatomegaly, splenomegaly, ecchymosis, osteomalacia. Associated with cholesterol stones (not pigment stones) due to reduced bile acid synthesis . Lab findings: | Serum 5' nucleotidase activity | Gamma-glutamyl transpeptidase activity | Serum bilirubin levels | Serum lipid levels | ALP Confirmation test- Liver biopsy Treatment of choice is liver transplantation.", 'role': 'assistant'}]