This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Glomerulonephritis, Subject name: Pathology
[{'content': 'A 50 year old male presented with symptoms of cutaneous vasculitis, glomerulonephritis and synovitis. Which of the following investigations will be helpful in the diagnosis? \nSelect and explain. \nA. P-ANCA, B. C-ANCA, C. Anti-HCV antibody, D. Anti-HAV antibody', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Essential mixed cryoglobulinemia: Formation of immune complexes (IgM -IgG) Development of renal lesions and involvement of joints (MPGN I and synovitis) Most cases have been associated with hepatitis C virus infection. Deposits of IgG-IgM complexes induce Cutaneous vasculitis Synovitis MPGN', 'role': 'assistant'}]