This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anaesthesia, Subject name: Pharmacology
[{'content': 'Neostigmine antagonizes non-depolarizing blockade by all of the following mechanisms except. \nSelect and explain. \nA. Decreasing the breakdown of acetylcholine at the motor end plate, B. Preventing the K+ efflux from the cell, C. Increasing the release of acetylcholine at the motor end plate, D. Depolarization at the motor end plate', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Ans. (B) Preventing the K+ efflux from the cell(Ref: Katzung 10th/e p436; KDT 8th/e p375)Neostigmine is an anti-cholinesterase. It inhibits the breakdown of ACh at the motor end plate. This results in the increased activity of ACh that causes depolarization of motor end plate by opening Na+ channels (increasing the influx of Na+). It possesses some direct agonistic activity on NM receptors resulting in depolarization. In addition, a minor effect to increase the release of ACh at motor end plate is also present.', 'role': 'assistant'}]