This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'In sickle cell trait, number of bands found in Hb- \nSelect and explain. \nA. 2, B. 1, C. 4, D. 5', 'role': 'user'}, {'content': 'Answer: A \nExplanation: In hemoglobin electrophoresis, various types of hemoglobin move at varying speed.\nIn Sickle cell trait (heterozygous state), there are two types of hemoglobin : - HbS (40%) and HbA (60%). So, on electrophoresis, two different bands are produced.\nIn homozygous state, almost all hemoglobin is HbS. So, a single band is produced.\n\nLaboratory findings of sickle cell anemia\n\nModerate to severe anemia.\nPeripheral smear will show\nSickle cells\nTarget cells\nHowell-Jolly bodies because of autosplenctomy.\nA positive sickling test with a reducing substance like sodium metabisulfite.', 'role': 'assistant'}]