This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Disorders of menstruation, Subject name: Gynaecology & Obstetrics
[{'content': 'Child with primary amenorrhea with negative progesterone challenge test but positive combined estrogen and progesterone test. Diagnosis may be: \nSelect and explain. \nA. Mullerian agenesis, B. PCOD, C. Asherman syndrome, D. Prolactinoma', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Positive combined estrogen and progesterone test means there is no sufficient estrogen for priming the endometrium so the pathology may lies in the hypothalamo-Pituitary-Ovarian axis Causes: Ovarian: Gonadal Dysgenesis, Premature Ovarian Failure, Resistant ovary syndrome , Autoimmune causes and Chemoradiation Pituitary: Pituitary Adenomas, Empty Sella Syndrome, Sheehans Syndrome, Infiltrative Pituitary Lesions Hypothalamic: Eating disorders , Congenital GnRH Deficiency [ Kallmann&;s Syndrome, GnRH Receptor Mutation Reference: Clinical Endocinologic Gynecology and infeility; Eigth Edition, Chapter 11', 'role': 'assistant'}]