This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
[{'content': 'Which of the following does not cross blood brain barrier \nSelect and explain. \nA. Pralidoxime, B. Obidoxime, C. Diacetylc-monooxime, D. Physostigmine', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Refer katzung 11e p 121 Pralidoxime or 2-PAM, usually as the chloride or iodide salts, belongs to a family of compounds called oximes that bind to organophosphate-inactivated acetylcholinesterase. It is used to treat organophosphate poisoning in conjunction with atropine and diazepam Pralidoxime is a quaternary charged oxime that can bind to inactivated ChE and reactivate its functional activity (Fig. ... However, because of the highly charged nature of 2-PAM, it has a poor ability to cross the blood brain barrier (BBB)', 'role': 'assistant'}]