This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'A 2 month baby presents with history of jaundice, turmeric colored urine and pale stools since birth. Examination reveals liver span of 10 cms. The most specific investigation for establishing the diagnosis would be – \nSelect and explain. \nA. Liver function tests, B. Ultrasound abdomen, C. Peroperative cholangiogram, D. Liver biopsy', 'role': 'user'}, {'content': 'Answer: D \nExplanation: The given clinical picture is suggestive of either of the following diagnosis:\n\nNeonatal hepatiits\nExtra hepatic biliary atresia\n\n"Percutaneous liver biopsy is the most valuable procedure in the evaluation of neonatal hepatobiliary disease and\xa0provides the most reliable discriminatory evidence".\nBiopsy findings of biliary atresia\n\nBile ductular proliferation\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\nPortal or perilobular edema and fibrosis.\nBile plug\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\nIntact basic hepatic lobular architecture.\n\nBiopsy findings of Neonatal hepatitis\n\nSevere, diffuse hepatocellular disease\nFocal hepatocellular necrosis.\nNo alteration in bile ductules.\nDistortion of lobular architecture.\nMarked infiltration with inflammatory cells.\n\nGiant cells are seen in both.', 'role': 'assistant'}]