This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hematology, Subject name: Pharmacology
[{'content': 'In the management of pulmonary emboli, alteplase (-PA) is infused for:- \nSelect and explain. \nA. 1-3 hours, B. 4-6 hours, C. 7-9 hours, D. 10-12 hours', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Alteplase : Also known as -PA(Recombinant tissue plasminogen activator) Has more affinity towards plasminogen bound to fibrin Due to sho duration of action, it is given by continuous iv infusion. The doses are: For MI: 15 mg iv bolus followed by 50 mg over 30 min and then 35 mg over next 60 min. For Pulmonary embolism: 100 mg iv over 2 hours For Ischemic stroke: 0.9 mg/kg iv over 60 min Note : Tenecteplase can be given as a single bolus dose for coronary thrombolysis.', 'role': 'assistant'}]