This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NEET 2018, Subject name: Biochemistry
[{'content': 'VMA is excreted in urine in:- \nSelect and explain. \nA. Alkaptonuria, B. Phenyl ketonuria, C. Diabetic ketoacidosis, D. Pheochromocytoma', 'role': 'user'}, {'content': 'Answer: D \nExplanation: VMA - (Vanillyl mantellic acid) which is an excretory product of catecholamine and increased in pheochromocytoma and neuroblastoma. Catabolism of catecholamine Enzymes involved are Mono amine oxide (MAO) Catechol-o-methyl transferase (COMT) Catabolic end product of Dopamine Nor- Epinephrine Epinephrine | | | Homo vanillic acid Nor Metanephrine Metanephrine So, we say VMA is the catabolic end product of two catecholamine - Epinephrine and Nor-Epinephrine For the diagnosis of Pheochromocytoma and neuroblastoma VMA levels are checked and the normal levels are 2-6 mg/24 hr urine sample.', 'role': 'assistant'}]