This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Irreversible cell injury is due to? \nSelect and explain. \nA. Membrane damage, B. Bleb formation, C. Loss of microvilli, D. Detachment of ribosomes', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Membrane damage is the central pathogenic process in irreversible injury\nAll other changes occur in reversible injury.', 'role': 'assistant'}]