This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Central Nervous system, Subject name: Pharmacology
[{'content': 'Drugs that can be used in opioid de-addiction are? \nSelect and explain. \nA. Clonidine, B. Diazepam, C. Methadone, D. All of the above', 'role': 'user'}, {'content': 'Answer: D \nExplanation: All of the drugs can be used. Methadone is effective orally, more potent ,longer acting and prevents withdrawal symptoms because it is slowly released from tissues. Clonidine a central alpha 2agonist can suppress autonomic.if withdrawal symptoms such as nausea, vomiting, anxiety and diarrhea. Night time sedation with a hypnotic like diazepam is helpful. Ref KD Tripathi 8th ed', 'role': 'assistant'}]