This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Intravenous Anesthetic Agents, Subject name: Anaesthesia
[{'content': 'Which of the following intravenous anaesthetic agent pharmacokinetic does not change on renal and hepatic dysfunction - \nSelect and explain. \nA. Propofol, B. Thiopentone, C. Etomidate, D. Ketamine', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Propofol is metabolized by liver and kidney mainly. but its metabolism exceeds hepatic blood flow, thus having extrahepatic and renal route as well. in liver and kidney dysfuction its metabolism is not delayed making its use safe.', 'role': 'assistant'}]