This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Breast, Subject name: Pathology
[{'content': 'Risk of breast carcinoma is most likely with which of the following conditions? \nSelect and explain. \nA. Sclerosing adenosis, B. Atypical epithelial hyperplasia, C. Fibrocystic change, D. Apocrine metaplasia', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Proliferative disease with atypia includes atypical lobular hyperplasia (ALH) and atypical ductal hyperplasia (ADH). Atypical ductal/lobular hyperplasia is associated with 4-5 times relative risk of breast carcinoma compared to non-proliferative breast changes. Conditions with lesser risk for carcinoma:- Sclerosing adenosis Fibrocystic change Apocrine metaplasia Duct ectasia Also know: Nonproliferative disease consists of three major morphologic changes: cysts, fibrosis, and adenosis. It is termed "nonproliferative" because the lesions contain single layers of epithelial cells. The most common nonproliferative breast lesions are simple cysts lined by a layer of luminal cells that often undergo apocrine metaplasia Proliferative disease without atypia includes epithelial hyperplasia, sclerosing adenosis, complex sclerosing lesion, and papilloma.', 'role': 'assistant'}]