This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Osteoporosis, Sex Hormones and OCPs, Subject name: Pharmacology
[{'content': 'All of the following agents act through nuclear receptors EXCEPT: \nSelect and explain. \nA. Thyroxine, B. Rosiglitazone, C. Prednisolone, D. Estrogen', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Prednisolone (coicosteroids) acts through cytoplasmic receptors whereas thyroid hormones (T3, T4), retinoids (vitamin A) and thiazolidinediones (like rosiglitazone) have nuclear receptors.', 'role': 'assistant'}]