This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: DNB 2018, Subject name: Pathology
[{'content': 'E- cadherin mutation is seen in which type of carcinoma: \nSelect and explain. \nA. IDC, B. Lobular carcinoma, C. Metabplastic carcinoma, D. Metastasis', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Loss of E cadherin can contribute to malignant phenotype by allowing easy disintegration of cell which can then invade locally and metastasize. Reduced cell surface expression of E cadherin has been noted in many carcinomas : Stomach carcinoma Breast carcinoma Prostate carcinoma Ovarian carcinoma', 'role': 'assistant'}]