This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of carbohydrate, Subject name: Biochemistry
[{'content': 'In glycolysis, the first committed step is catalyzed by \nSelect and explain. \nA. 2,3 DPG, B. Hexokinase, C. Pyruvate kinase, D. Phosphofructokinase', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Glucose enters glycolysis by phosphorylation to glucose 6-phosphate, catalyzed by hexokinase, using ATP as the phosphate donor. Under physiological conditions, the phosphorylation of glucose to glucose-6-phosphate can be regarded as irreversible. Hexokinase is inhibited allosterically by its product, glucose-6-phosphate. Reference: Harper; 30th edition; Page no: 169', 'role': 'assistant'}]