This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pharmacokinetics, Subject name: Pharmacology
[{'content': 'Rate of elimination of drug is: \nSelect and explain. \nA. Clearance, B. Tl/2, C. Biotransformation, D. Bioavailability', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans: A (Clearance) Ref: Basic & Clinical Pharmacology, Katzung 12th ed. P.38Explanation:Clearance of a drug is the factor that predicts the rate of elimination in relation to the drug concentrationClearance = rate of elimination/plasma concentrationBiotransformation: It is a chemical modification ( or modifications) made by human body on a chemical compound.Drug biotransformations have 2 classical reactions: Phase I and Phase II. (See the following figure)Bioavailability: It is the fraction of administered drug that reaches the systemic circulation. Bioavailability is expressed as the fraction of administered drug that gains access to the systemic circulation in a chemically unchanged form.', 'role': 'assistant'}]