This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Wire loop thickening of glomerular basement membrane is seen in - \nSelect and explain. \nA. Systemic lupus erythematosus (SLE), B. Non Insulin Dependent Diabetes Mellitus, C. Rapidly progressive glomerulonephritis, D. Malignant hypeension', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Systemic lupus erythematosus o Wire loop thickening is a characteristic features of lupus nephritis. o It occurs because extensive subendothelial deposit in kidney causes a peculiar thickening of the capillaries which on light microscopy appear as wire loop lesions. o Wire loop lesions indicate active disease and poor prognosis. o Wire loop lesions are especially common in diffuse proliferative glomerulonephritis, but can also occur in focal proliferative and membranous glomerulonephritis.", 'role': 'assistant'}]