This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
[{'content': 'An infant presents with irritability, increased tone of extremities and recurrent seizures.  Tissue examination reveals globoid cells in parenchyma around blood vessels.  What is the most probable diagnosis? \nSelect and explain. \nA. Taysach’s disease, B. Krabbe disease, C. Adrenoleukodystrophy, D. Kanavan’s disease', 'role': 'user'}, {'content': 'Answer: B \nExplanation: (Refer: Nelson’ss textbook of pediatrics, 19th\xa0edition, pg no: 2071-2072)\nKrabbe disease (KD)/globoid cell leukodystrophy\n\nAutosomal recessive neurodegenerative disorder.\nCharacterized by severe myelin loss and the presence of globoid bodies in the white matter.\nDeficiency of lysosomal enzyme galactocerebroside β- galactosidase (galactosylceramidase).\nAccumulation of galactocerebroside causes activation of an alternative catabolic pathway removes a fatty acid from this molecule, generating galactosylphingosine.\nIn patients with KD, galactocerebroside cannot be metabolized during the normal turnover or myelin because of deficiency of galactocerebroside β-galactosidase.\nBecause oligodendroglial cells are responsible for the elaboration of myelin, their loss results in myelin breakdown, thus producing additional galactocerebroside and causing a vicious circle of myelin destruction.', 'role': 'assistant'}]