This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Carbohydrates, Subject name: Biochemistry
[{'content': 'Fructose intolerance is due to deficiency of: \nSelect and explain. \nA. Fructokinase, B. Aldolase-B, C. Fructose 1,6 bisphosphatase, D. Fructose synthase', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Ans: b (Aldolase - B) Ref: Vasudevan, 4th ed, p. 120Hereditary fructose intolerance is due to defect in the enzyme Aldolase-B.Hereditary fructose intolerance:Defect: Aldolase-B enzyme deficiency( fructose 1 PO4 aldolase activity).Lethargy, vomiting, diarrhoea, hypoglycaemia.Liver damage, hyper bilirubinaemia (deposition of fructose 1 PO4 in liver and kidney).Hyper uricaemia, lactic acidosis.Renal proximal tubular defect (fanconi).Cataract is not a feature of this disease, because fructose is not an Aldose sugar and therefore not a substrate for aldose reductase in the lens.Treatment - Eliminate fructose from diet.Fructokinase deficiency is usually asymptomatic.', 'role': 'assistant'}]