This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'The therapeutic efficacy of antihypeensive drug is blunted by NSAIDs because they: \nSelect and explain. \nA. Cause sodium excretion, B. Increase the clearance of antihypeensive drugs, C. Decrease the absorption of antihypeensive drugs, D. Decrease the synthesis of vascular prostacyclin', 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans. is 'd' i.e., Decrease the synthesis of vascular prostacyclin o NSA IDs blunt the antihypeensive effect of diuretics. o Loop diuretics act paly (intrarenal hemodynamics) by increasing the synthesis of prostaglandins by stimulation of COX o Prostaglandins (especially PGE2 and PGI2) cause renal vasodilation, natriuresis and increased water clearance due to inhibition of the ADH action. o NSAIDs inhibit the synthesis of prostaglandins by inhibiting COX. Therefore, NSAIDs blunt the diuretic effect of loop diuretics.", 'role': 'assistant'}]