This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Medicine
[{'content': 'Central nervous system manifestion in chronic renal failure are a result of all of the following except - \nSelect and explain. \nA. Hyperosmolarity, B. Hyperparathyroidisn, C. Acidosis, D. Hyponatremia', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Chronic renal failure results in- Sodium and water retention leading to hyponatremia(not common and responds to water restriction). Decreased ca absorption -Hypocalcemia-increase in PTH -Hyperphosphatemia,increased bone resorption resulting in hypercalcemia-deposition of calcium in extraosseous sites such as vascular bed and soft tissues. Hyperkalemia Hyperchloremic metabolic acidosis is present in early stages of ckd(1-3). Ref:HARRISON 20 th edition pg no. 2114,2115', 'role': 'assistant'}]