This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
[{'content': 'A 60 yr old lady is concerned about the wrinkles around her eyes.This is due to defect in \nSelect and explain. \nA. Collagenase, B. Desmosine, C. Fibrillin, D. collagen cross linking', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Collagen cross-linking: Cross linking occurs when a protein linked to other protein,lipid or sugar which is necessary for normal collagen function. Abnormal cross linking causes wrinkles/ages skin which is due to glucose mediated advance glycation end products(AGE),UV mediated free radical damage. Collagenase: Defect in collagen leads to increased level of collagen Collagenase inhibitor are given to treat wrinkles Desmosine: Desmosine is formed by 3allsyl side chains and one unaltered lysyl side chain of elastin. Fibrillin: It is a glycoprotein secreted by fibroblasts. It forms a framework of elastin deposition Defect in fibrillin-1 results in Marfans syndrome Reference: Harpers illustrated biochemistry 30th edition', 'role': 'assistant'}]