This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Thiazolidinedione is associated with increasedrisk of? \nSelect and explain. \nA. Hea failure, B. Pulmonary fibrosis, C. Myocarditis, D. renal dysfunction', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Hea failure Thiazolidinediones adverse effects Plasma volume expansion, edema, weight gain, headache, myalgia and mild anemia. Few cases of hepatic dysfunction and some cardiovascular events have been repoed - CHF may be precipitated - they are contraindicated in liver disease and in CHF. Rosiglitazone has been found to increase the risk of fracture, especially in elderly women. Glitazones with insulin can precipitate CHF - avoid such combination. These drugs prevent type 2 DM in prediabetics.", 'role': 'assistant'}]