This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Blood, Subject name: Pathology
[{'content': 'Most common type of inherited disease of hypercoagulobility is? \nSelect and explain. \nA. Protein C deficiency, B. Leiden mutation, C. DIC, D. Antithrombin III deficiency', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e., Leiden mutation * Of the inherited causes of hypercoagulability, mutation in factor V gene is the most common.* Factor V mutations (called the leiden mutation) causes subsitution of arginine residue (at position 506) by glutamine.* This mutation makes factor V resistant to cleavage by protein 'C* (normally protein 'C is one of the factor that regulates coagulation by inactivating factor V & VIII).* This results in unchecked coagulation.", 'role': 'assistant'}]