This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Social & Preventive Medicine
[{'content': 'Aperson is on intensive chemotherapy, which vaccine is contraindicated in this circumstance ? \nSelect and explain. \nA. MMR, B. Hepatitis B, C. Pneumococcus, D. DPT', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., MMR o Live vaccines (MMR, Varicells zoster, BCG, LAIV) should be postponed until after chemotherapy or long-term high? dose steroid therapy has ended. Note : LAIV is live attenuated influenza vaccine. o Live attenuated vaccine should not be used in immunocompromized patients -4 The virulence of organism has been reduced, it is non-pathogenic in immunocompetent patients. In immunocompromized patients this reduced level may be pathogenic i.e., It can produce disease in immunocompromized patients. o So, live attenuated vaccines are contraindicated if the patient is immunocompromised due to : Coicosteroid therapy Anticancer therapy (alkylating agents) Severe malnutrition Congenital immunodeficiency (Hypogammaglobulinemia) Symptomatic HIV infection Lymphoma or generalized malignant disease o Only absolute contraindication to killed vaccines is severe local or general reaction to previous dose.", 'role': 'assistant'}]