This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Central Nervous system, Subject name: Pharmacology
[{'content': 'Drug of choice for rapid cyclers in manic-depressive psychosis is: \nSelect and explain. \nA. Carbamazepine, B. Valproate, C. Phenytoin, D. Lithium', 'role': 'user'}, {'content': 'Answer: B \nExplanation: uction in manic relapses is noted when valproate is used in bipolar disorder. It is now a first line treatment of acute mania in which high dose valproate acts faster and is an alternative to antipsychotic +- benzodiazepine. It can be useful in those not responding to lithium or not tolerating it. Patients with rapid cycling pattern may paicularly benefit from valproate therapy Ref: KD Tripati 8th ed.', 'role': 'assistant'}]