This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Sickle Cell Anemia, Subject name: Medicine
[{'content': 'Sickle cell anemia leads to resistance towards? \nSelect and explain. \nA. P. falciparum, B. P. ovale, C. P. malariae, D. P. vivax', 'role': 'user'}, {'content': 'Answer: A \nExplanation: ANSWER: (A) P. falciparumREF: Harrisons 17th ed chapter 213, Essentials of clinical immunology by Helen Chapel, Mansel Haeney, Siraj Misbah 5th edition Page 48\'Although sickle cell anemia kills homozygous individuals in early life, this disadvantage is balanced by the resistance that the trait affords heterozygous individuals to Plasmodiiim falciparum because sickled RBC is less hospitable to the parasite"\'Note: Absence of RBC Duffy antigen confers resistance to P. Vivax', 'role': 'assistant'}]