This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'The highest life time risk of pancreatic malignancy is seen with: \nSelect and explain. \nA. Peutz-Jeghers syndrome, B. Hereditary nonpolyposis colorectal cancer, C. Li-Fraumeni syndrome, D. Familial adenomatous polyposis', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Peutz-Jeghers, associated with mutations in the STK11 gene. It has the highest lifetime risk of pancreatic cancer. Genetically driven chronic causes of pancreatic cancers are hereditary pancreatitis, cystic fibrosis, and ataxia telangiectasia. Ref: Harrison, Edition -18, Page-788', 'role': 'assistant'}]