This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Respiratory chain, Subject name: Biochemistry
[{'content': 'Uncoupler in ETC \nSelect and explain. \nA. H2S, B. Antimycin a, C. 2, 4-dinitrophenol, D. Barbiturates', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Dinitrophenol (DNP) a potent uncoupler is amphipathic and increase the permeability of the lipoid inner mitochondrial membrane to protons (H+), thus reducing the electrochemical potential and sho-circuiting the ATP synthase. In this way, oxidation can proceed without phosphorylation.Ref: MN Chatterjea Textbook of Medical Biochemistry, 8th edition, page no: 146', 'role': 'assistant'}]