This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemical Mediators and Regulators of Inflammation, Subject name: Pathology
[{'content': 'Which is not the action of TGF-b \nSelect and explain. \nA. Anti-inflammatory, B. Proliferation of fibrous tissue, C. Inhibition of metalloproteinases, D. Anaphylaxis', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Ans. (d) Anaphylaxis(Ref: Robbins 9th/pg 86-87, 105, Immunology: Mucosal and Body Surface Defences, 4.8)Transforming growth factor-b (TGF-b) is the most important cytokine for the synthesis and deposition of connective tissue proteins. Other functions: Angiogenesis. Anti-inflammatory cytokineUp-regulation of tissue inhibitor of metalloproteinas- es-3 gene expression is done by TGF-beta in articular chondrocytes', 'role': 'assistant'}]