This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': 'Neostigmine antagonizes nondepolarizing blockade by all of the following mechanisms, except ? \nSelect and explain. \nA. Decreasing the breakdown of Acetylcholine at the motor end plate, B. Preventing K+ efflux from the cell, C. Increasing the release of Acetylcholine at the motor end plate, D. Depolarization of the motor end plate', 'role': 'user'}, {'content': "Answer: C \nExplanation: Ans. is 'c' i.e., Increasing the release of Acetylcholine at the motor end palate o Anticholinestrases act by inhibiting the action of acetylcholinesterase (an enzyme that degrades acetylcholine by causing its hydrolysis). o Anticholinesterases thus increase the level of acetylcholine at the neuromuscular junction. o Neostigmine also has some additional direct action on cholinergic receptors i.e., it depolarizes motor end plate. o It does not increase the release of ACH. Accumulated ACH acts on prejunctional muscarinic autoreceptors and inhibits the release of ACH.", 'role': 'assistant'}]