This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Basics of genetics, Subject name: Biochemistry
[{'content': 'Most lethal karyotype is? \nSelect and explain. \nA. 45, YO, B. 45, XO, C. 47, XXY, D. 48, XYYY', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Most lethal karyotype is 45,YO Monosomy is more dangerous than trisomy. Turner Syndrome(X0) is only monosomy compatible with life. 45,YO karotype is fetal in utero and not compatible with life Monosomy In Autosomes In Sex Chromosome Not found Lethal Turner Syndrome (XO) Viable', 'role': 'assistant'}]