This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Chronic Active Hepatitis is most reliably distinguished from chronic Persistent hepatitis by the presence of \nSelect and explain. \nA. Extrahepatic manifestation, B. Significant titre of antismooth muscle antibody, C. Characteristic liver histology, D. Hepatitis B surface antigen', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Minimal chronic hepatitis (previously called chronic persistent hepatitis).\nThe portal chronic inflammation is mild and is restricted to the portal triads without extension into the Liver\xa0lobule across the limiting plate.\nChronic active hepatitis →\xa0characterized by continuing necrosis of Liver cells. The severe inflammation\xa0disrupts the limiting plate.', 'role': 'assistant'}]