This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
[{'content': 'Mechanism of action of paxclitaxel is \nSelect and explain. \nA. Topisomaerse inhibition, B. Increase the polymerization of tubulin, C. Inhibits protein synthesis, D. Alkylation of DNA', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Refer Katzung 10th/893 Refer KDT 6/e p825 Taxanes act by increasing the polymerization of beta tubulin whereas vinca alkaloid cause inhibition of tubulin polymerization. Both of these drugs act by causing the disruption of mitosis and are active in M phase of cell cycle', 'role': 'assistant'}]