This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General, Subject name: Medicine
[{'content': 'Which of the following is involved in tumor metastasis cascade:- \nSelect and explain. \nA. Fibronectin, B. E-Cadherin, C. Type IV collagenase, D. Tyrosine kinase', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e. E. cadherin For the tumor cells to metastasize they must-1st - detach from each other.Next - traverse the extracellular matrix (i. e. the basement membrane and interstitial connective tissue).Normally the cells are neatly glued to each other and their surrounding by a variety of adhesion molecules.Of these the E-Cadherin is most important. Any abnormality of E-cadherin molecule or down-regulation of its expression would lead to detachment of the cells from the primary tumor and move out for metastasis.", 'role': 'assistant'}]