This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Introduction and gametogenesis., Subject name: Anatomy
[{'content': 'In a young female of reproductive age with regular menstrual cycle of 28 days, ovulation occurs at around 14th day of periods. When is the first polar body extruded? \nSelect and explain. \nA. 12 hrs prior to ovulation, B. Accompanied by ovulation, C. 48hrs after the ovulation, D. At the time of ovulation', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Primary oocyte remain in prophase of meiosis I until primodial follicle grow to form primary follicle which grows to form secondary/graffian follicle. The secondary follicle enters preovulatory stage 36 hrs before ovulation when LH surge occurs resulting in completion of meiosis -I and formation of secondary oocyte and 1st polar body 12hrs prior to ovulation(LH peak occurs).', 'role': 'assistant'}]