This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
[{'content': 'Loss of heterozygosity associated with \nSelect and explain. \nA. Acute myeloid leukemia, B. ALL, C. Retinoblastoma, D. Promyelocytic leukaemia', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ref Robbins 9/e p292_293 familial case of retinoblastoma 1 defective and 1 normal gene at bih (heterozygous) second mutation causes both genes to be defective loss of heterozygosity Increased chances of cancer sporadic case of retinoblastoma both normal gene at bih _ homogeneous normal genes Both mutations occur somatic Ally within a single cell (homozygous abnormal genes ) increased chances of cancer', 'role': 'assistant'}]