This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
[{'content': 'Anemia of chronic disease is characterised by \nSelect and explain. \nA. Increased sideroblast, B. Increased TIBC, C. Increased bone marrow iron, D. Increased protoporphyrin', 'role': 'user'}, {'content': 'Answer: C \nExplanation: (Ref: Robbins 8/e p662)\n\nAnemia of chronic disease- Impaired red cell production associated with any chronic diseases that would be infectious/inflammatory/neoplastic.\nChronic diseases produce a cytokine “IL-6” that increases the production of hepcidin from liver.\xa0 Hepcidin inhibits ferroportin function in macrophages and reduces the transfer of iron from storage pool to developing erythroid precursors in bone marrow.\nSo the patient develop anemia irrespective of increased amount of iron in macrophages.\nLaboratory findings- Increased ferritin (storage iron), Low serum iron\xa0 and reduced total iron binding capacity.\nWhereas in iron deficiency anemia, the patient will have decreased ferritin, lowserum iron and high iron binding capacity.', 'role': 'assistant'}]