This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Surgery
[{'content': 'Mutation not seen in diffuse type of gastric cancer? \nSelect and explain. \nA. E-cadherin, B. APC, C. p16, D. p53', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Hereditary diffuse gastric cancer is an inherited form of gastric cancer. Patients with this disorder, resulting from a gene mutation for the cell adhesion molecule E-cadherin, have an 80% lifetime incidence of developing gastric cancer. Inactivation of the tumor suppressor genes p53 and p16 has been repoed in diffuse and intestinal-type cancers. Adenomatous polyposis coli gene mutations tend to be more frequent in intestinal-type gastric cancers. Sabiston 20e pg: 1240.', 'role': 'assistant'}]