This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Structure and function of protein, Subject name: Biochemistry
[{'content': 'Familial hypercholesterolemia is associated with \nSelect and explain. \nA. Liver cirrhosis, B. Premature atherosclerosis, C. Nephrotic syndrome, D. Pancreatitis', 'role': 'user'}, {'content': 'Answer: B \nExplanation: A positive correlation exists between the incidence of atherosclerosis and the plasma concentration of LDL cholesterol. The LDL (apoB-100, E) receptor is defective in familial hypercholesterolemia, a genetic condition which blood LDL cholesterol levels are increased, causing premature atherosclerosis.Ref: Harper&;s Biochemistry; 30th edition; Chapter 25; Lipid Transpo & Storage', 'role': 'assistant'}]