This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology metabolism, Subject name: Physiology
[{'content': 'Genetic expression of Na KATPAse inducible by- \nSelect and explain. \nA. Aldosterone, B. Cortisol, C. Thyroxine, D. ACTH', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e.. Aldosterone Mineralocorticoid actionso The principal mineralocorticoid secreted by adrenal cortex is aldosterone.o The main action of aldosterone is to enhance Na+ reabsorption in the distal convoluted tubule in kidney.o There is an associated increase in K+ and H+ excretion.Excess mineralocorticoid - Na+ and water retention (Hypertension & edema), Hypokalemia, Alkalosis.Mineralocorticoid deficiency (Addison's disease) - Hyperkalemia. Acidosis, Hypotension,o Mechanism of actionMineralocorticoid acts on cytoplasmic receptors.It increases transcription of m.RNA in renal tubular cells to symthesis Aldosterone - induced protein (ATP) which is Na+ K+ ATPase.Symthesis of b-subunit of amiloride sensitive Na+ channel is also induced.", 'role': 'assistant'}]