This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Kaposi sarcoma arise from - \nSelect and explain. \nA. Muscles, B. Connective tissue, C. Vascular tissue, D. None of the above', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Kaposi sarcoma is an intermediate grade, multicentric vascular, tumour\nThe pathogenesis of Kaposi sarcoma is complex, fundamentally it is an angio proliferative disease that is not a\ntrue neoplastic sarcoma.\nIt is a manifestation of excessive proliferation of spindle cells that are believed to be of vascular origin and have featured in common with endothelial and smooth muscle cells.\nGrossly → There stages of the disease can be identified\nPatch (Ist stage)\nPlaque (intermediate stage)\nNodule (last stage)\nHistologically - The changes are nonspecific in the early patch stage and more characteristic in the nodular stage\xa0which show.\nSheets of plump proliferating spindle cells and endothelial in the dermis or subcutaneous tissue\xa0More on Kaposi Sarcoma\xa0C/f of Kaposi Sarcoma.\nKaposi sarcoma lesions most commonly appear as raised macules, however, they can also be papular or\xa0nodular.\nLesions often appear in the sun-exposed areas, particularly the tip of the nose. Confluent lesions may give rise to\nsurrounding lymphedema and may be disfiguring when they involve the face and disabling when they involve the lower extremities.\nApart from skin, Kaposi sarcoma can involve almost any other organ such as lymph nodes, gastrointestinal tract and lung.\nIn contrast to most malignancies in which lymph node involvement implies metastatic spread and a poor prognosis, lymph node involvement is seen very early in Kaposi sarcoma and is of no special clinical signs', 'role': 'assistant'}]