This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
[{'content': 'Which is the pathognomic feature of Alzheimer’s disease? \nSelect and explain. \nA. Lewy bodies, B. Ballooned neurons, C. Plaques and tangles, D. Pick bodies', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ref. Robbins Pathology. 9th edition. Page. 1289\n\xa0\n\nGrossly, brain atrophy (narrowed gyri and widened sulci) is predominant in the frontal and superior temporal lobes.\nAlzheimer microscopically characterized by numerous neuro brillary tangles and senile plaques with a central core of amyloid alpha protein\nSilver stains demonstrate tangles and plaques and Congo red shows amyloid deposition in plaques and vascular walls (amyloid angiopathy).\nThere are also numerous Hirano bodies, and granulovacuolar degeneration is found in more than 10 of the neurons of the hippocampus.', 'role': 'assistant'}]