This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Pathology
[{'content': 'Mercury affects which part of the kidney - \nSelect and explain. \nA. PCT, B. DCT, C. Collecting duct, D. Loop of Henle', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. (a) PCT(Ref: Robbins 9th/pg 928; 8th/pg 938)Nephrotoxic AKI*Caused by Gentamicin, radiographic contrast agents, heavy metals (eg mercury), organic solvents (eg CCl4 ).*Extensive necrosis along mainly proximal convoluted tubule (PCT) & ascending limb of Henle's loop.*On histologic examination, non-specific tubular necrosis, with some distinctive features:Mercuric chlorideSeverly injured cells contain large acidophilic inclusions, become totally necrotic, & may undergo calcification.Carbon tetrachlorideAccumulation of neutral lipids (fatty change), followed by necrosis.Ethylene glycolMarked ballooning & hydropic or vacuolar degeneration of proximal convoluted tubules. Ca oxalate crystals are often found in the tubular lumens in such poisoning.", 'role': 'assistant'}]