This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
[{'content': 'Cell which does not migrate from the base of the crypt ends of villi is \nSelect and explain. \nA. Enterocyte, B. Endocrine cell, C. Paneth cell, D. Goblet cell', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Paneth cells, along with goblet cells, enterocytes, and enteroendocrine cells, represent the principal cell types of the epithelium of the small intestine. (A few may also be found sporadically in the cecum and appendix.) They are identified microscopically by their location just below the intestinal stem cells in the intestinal glands (crypts of Lieberkuhn) and the large eosinophilic refractile granules that occupy most of their cytoplasm. These granules consist of several anti-microbial compounds and other compounds that are known to be impoant in immunity and host-defense. When exposed to bacteria or bacterial antigens, Paneth cells secrete some of these compounds into the lumen of the intestinal gland, thereby contributing to maintenance of the gastrointestinal barrier.', 'role': 'assistant'}]