This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Medicine
[{'content': 'Highly selective proteinuria is seen in \nSelect and explain. \nA. Minimal change, B. Mesangial proliferative nephritis, C. Membranous glomerulonephritis, D. Focal glomerulosclerosis', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Loss of glomerular basement membrane (GBM) polyanion has been proposed as a cause of the selective proteinuria in minimal change nephrotic syndrome (MCNS).The exact role of charge selectivity in the pathogenesis of nephrotic proteinuria remains controversial Proteinuria that is more than 85% albumin is selective proteinuria. Nonselective proteinuria, being a glomerular leakage of all plasma proteins, would not involve changes in glomerular net charge but rather a generalized defect in permeability Ref Harrison20th edition pg 287', 'role': 'assistant'}]