This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': "'Knudson's two-hit' hypothesis is associated with \nSelect and explain. \nA. Crohn's disease, B. Melanoma, C. Ulcerative colitis, D. Retinoblastoma", 'role': 'user'}, {'content': 'Answer: D \nExplanation: Harshmohan textbook of pathology 7th edition. \n☆ Familial retinoblastoma comprises 40% of cases and may be bilateral. \nIn this cases, all somatic cells inherit one mutant RB gene from a carrier parent. Later during life, the other mutational event of 2nd allele affecting the somatic cells occurs.\nThis forms the basis of two hot hypothesis given by Knudson in 1971.', 'role': 'assistant'}]