This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Cytokines are secreted in sepsis and Systemic Inflammatory Response syndrome (SIRS) by - \nSelect and explain. \nA. Neutrophils, B. Adrenal, C. Platelets, D. Collecting duct', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Cytokine release in Sepsis \n\nThe mechanism by which endotoxin causes activation of inflammatory cells and release of cytokines has already been explained earlier.\nIt is by TL -4 and CD-14 mediated.\nSignals from TLR-4 can directly activate vascular endotheliun and leukocytes to release cytokine mediators.\nThe major cells that secrete cytokines in sepsis area\n\n\nMonocyte/Macrophages\xa0\xa0\xa0\xa0\xa0\xa0 \nNeutrophils\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\nEndothelial cells\n\n\nCytokine mediators involved are:-\n\n\nTNF\xa0- (The most important cytokine in sepsis)\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0 \nIL-1\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0 \nIL-6\xa0\xa0\xa0\xa0\xa0\xa0 \nIL-8\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0 \nNO.', 'role': 'assistant'}]