This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Urology, Subject name: Anatomy
[{'content': 'A 50-year-old male with a positive family history of prostate cancer has come to you for a screening test. The most sensitive screening test to pickup prostate cancer is \nSelect and explain. \nA. DRE, B. PSA, C. DRE + PSA, D. Endorectal Coil MRI with T1W and T2W images', 'role': 'user'}, {'content': 'Answer: C \nExplanation: At the present time the data suggest that if screening is done, the combination of DRE & Serum PSA is best." The diagnosis of Ca Prostate is established by TRUS-guided transrectal biopsy. Ref : Smith\'s Urology 17/e p363', 'role': 'assistant'}]