This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Gestational Trophoblastic Disease, Subject name: Gynaecology & Obstetrics
[{'content': 'The best investigation to diagnose carcinoma cervix in early stages: \nSelect and explain. \nA. Colposcopic biopsy, B. Aceto White over lesion, C. Pap smear, D. Hysteroscopy', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Ans. C. Pap smearPap smear is a screening test. It is the initial test in all patients unless a visible growth is present that needs to be biopsied. Colposcopy is also a screening test that is done in well-equipped centers. It is costly and needs more expertise. Aceto White lesion has many differentials ranging from leukoplakia, SIL, cancer, HPV infection to metaplasia. This technique is used in periphery where there is no facility of Pap smear and colposcopy to identify the high-risk cases. Hysteroscopy is for diagnosis of uterine lesion. Of the options listed here, Pap smear is the best answer.', 'role': 'assistant'}]