This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'In sickle cell trait, number of bands found in Hb – \nSelect and explain. \nA. 2, B. 1, C. 4, D. 5', 'role': 'user'}, {'content': 'Answer: A \nExplanation: In hemoglobin electrophoresis, various types of hemoglobin move at varying speed.\nIn sickle cell trait (heterozygous state), there are two types of hemoglobin - HbS (40%) and HbA (60%). So, on electrophoresis, two different bands are produced.\nIn Homozygous state, almost all hemoglobin is HbS. So, a single band is produced.\n\nLaboratory findings of sickle cell anaemia\n\nModerate to severe anaemia\nPeripheral smear will show\nSickle cells\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\nTarget cells\nA positive sickling test with a reducing substance like sodium metabisulfite.\nHowell - Jolly bodies because of autosplenectomy', 'role': 'assistant'}]