This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: JIPMER 2017, Subject name: Pathology
[{'content': 'All of the following are true about Xeroderma pigmentosum except: \nSelect and explain. \nA. Skin manifestations appear within first 2 years of life, B. Increased risk of non melanotic skin cancers, C. Nucleotide excision repair defect, D. Autosomal dominant inheritance', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Xeroderma Pigmentosum At increased risk for the development of cancers of the skin paicularly following exposure to the UV light contained in sun rays. UV radiation causes cross-linking of pyrimidine residues, preventing normal DNA replication. Such DNA damage is repaired by the nucleotide excision repair system. Increased risk of both melanocytic and non-melanocytic cancer. Eg : Xeroderma Pigmentosum Big FAX (Inherited disorder of DNA repair) Big: Bloom syndrome F: Fanconi anemia A: Ataxia telangiectasia X: Xeroderma pigmentosum', 'role': 'assistant'}]