This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'In the well fed state, major fate of glucose-6-phosphate in tissues is: \nSelect and explain. \nA. Storage as fructose, B. Storage as glyceraldehyde-3-phosphate, C. Enters HMP shunt via ribulose-5-phosphate, D. Storage as glycogen', 'role': 'user'}, {'content': 'Answer: D \nExplanation: The\xa0uptake\xa0of\xa0glucose\xa0into\xa0 the\xa0 liver through\xa0GLUT\xa02\xa0is independent of insulin.\nIn the well fed state, the concentration of glucose entering\xa0the\xa0liver\xa0increases,\xa0so\xa0does\xa0the\xa0rate\xa0of synthesis of glucose-6-phosphate.\nThis\xa0is\xa0in\xa0excess\xa0of\xa0the\xa0liver’s\xa0requirement\xa0forenergy-yielding metabolism. So,\xa0it is used mainly for synthesis of glycogen.\nIn\xa0both\xa0liver\xa0and\xa0skeletal\xa0muscle, insulin acts\xa0to stimulate glycogen synthase and inhibit glycogen phosphorylase.\n\nHarper 30th edition pg -148', 'role': 'assistant'}]