This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Medicine
[{'content': 'Most unlikely cause of acute tubular necrosis amongst the following is - \nSelect and explain. \nA. Severe bacterial infection, B. Massive burn, C. Severe cursh injury in the foot, D. Rupture of aoic aneurysm', 'role': 'user'}, {'content': 'Answer: D \nExplanation: ISCHEMIA alone in a normal kidney is usually not sufficient to cause severe AKI, as evidenced by the relatively low risk of severe AkI even after suprarenal aoic clamping or cardiac arrest. (so rupture of aoic aneurysm is the most unlikely cause of ATI. ) AKI is an ominous complication of burns affecting 25%of individuals with >10%total body surface area involvement . In addition to hypovolemia, burns and acute pancreatitis both lead to dysregulated inflammation and increased risk of sepsis and acute lung injury which facilitate the development of AKI. Ref: Harrison20th edition pg 297', 'role': 'assistant'}]