This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Most impoant prognostic factor of wilms tumour - \nSelect and explain. \nA. Histopathology, B. Ploidy of cells, C. Age < 1 yr, D. Mutation, of clp gene', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. is \'a\' i.e., Histopathology o Anaplastic nuclear change is the only criterion of "unourable" histology in Wilm\'s tumor and all Wilm\'s tumor lacking this feature are designated as having "ourable histology". o Anaplastic nuclear change reflects extreme polypoidy & is usually apparent under low magnification. "Anaplastic histology remains a critical determinant of adverse prognosis. Even anaplasia restricted to kidney confers an increased risk of recurrence & death, underscoring the need for correctly identifying this histologic features."', 'role': 'assistant'}]