This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Carbohydrates, Subject name: Biochemistry
[{'content': 'A chronic alcoholic has recently had trouble with their ability to balance, becomes easily confused, and displays nystagmus. An assay of which of the following enzymes can determine a biochemical reason for these symptoms? \nSelect and explain. \nA. Isocitrate dehydrogenase, B. Transaldolase, C. Glyceraldehyde-3-phosphate dehydrogenase, D. Transketolase', 'role': 'user'}, {'content': 'Answer: D \nExplanation: The patient has the symptoms of beriberi, which is caused by a thiamin deficiency. Of the enzymes listed, transketolase would be less active because it requires thiamin pyrophosphate as a cofactor. The other enzymes listed do not require cofactors except for the three dehydrogenases, which require either NAD+orNADP+, depending on the enzyme.', 'role': 'assistant'}]