This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
[{'content': 'Asteroid bodies are seen in histological examination in tissues infected with which of the following causative agent? \nSelect and explain. \nA. Histoplasmosis, B. Aspergillosis, C. Sporotrichosis, D. Nocardiosis', 'role': 'user'}, {'content': "Answer: D \nExplanation: Asteroid bodies are seen in association with Sporotrichosis. Sporotrichosis is an infection caused by Sporothrix schenckii a thermally dimorphic fungus. In H&E stained tissue, the asteroid body consists of a central basophilic yeast cell surrounded by radiating extensions of eosinophilic material, which are depositions of antigen antibody complexes and complement. Sporotrichosis occurs following traumatic inseion of S schenckii into the skin. The initial lesion is usually located on an extremity which later develops into a granulomatous nodule that may progress to form a necrotic or ulcerative lesion. The draining lymphatics becomes thickened and cor like. It can be seen when stained with Gomori methenamine silver or periodic acid-Schiff stain. It can be cultured on Sabouraud's agar containing antibacterial antibiotics and incubated at 25-30degC. Ref:Brooks G.F., Carroll K.C., Butel J.S., Morse S.A., Mietzner T.A. (2013). Chapter 45. Medical Mycology. In G.F. Brooks, K.C. Carroll, J.S. Butel, S.A. Morse, T.A. Mietzner (Eds), Jawetz, Melnick, & Adelberg's Medical Microbiology, 26e", 'role': 'assistant'}]