This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Infection, Subject name: Medicine
[{'content': 'Treatment of choice in complicated Plasmodium falciparum is \nSelect and explain. \nA. Chloroquine, B. Quinine, C. Artemether, D. Artesunate', 'role': 'user'}, {'content': 'Answer: D \nExplanation: (Artesunate) (1288-90-H17th)* Artesunate is the treatment of choice for severe falciparum malaria (1323-24-CMDT-09)Treatment of MalariaClinical settingDrug TherapyAlternative drugs* Chloroquine sensitiveP- falciparum andP. malaria infectionsChloroquine * Plasmodium vivax and P. ovale infectionsChloroquine then (If G6PD normal) primaquine-* Uncomplicated infections with chloroquine resistantP. falciparumQuinine sulfate plus Doxycycycline or Clinidamycin for 7 days orFansidar - three tablets onceMalarone or Mefloquine orAtcsunate or artermether orCortem* Severe or complicated infections with P. falciparumArtesunateQuinidine gluconate orArtemether* IV Artesunate, a water soluble artemisinin derivative has been shown to reduce mortality rates in severe falciparum malaria by 35% from rates obtained with quinine. Artesunate has therefore become the drug of choice', 'role': 'assistant'}]