This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Lipids, Subject name: Biochemistry
[{'content': 'Which organelle is involved in the case of sphinghomyelin deficiency: \nSelect and explain. \nA. Lysosome, B. Nucleus, C. Mitochondria, D. Cell membrane', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. (a) LysosomeRef: Harper's Biochemistry, 30th ed. pg. 251* Sphinghomyelin is a major neural tissue component, the core structure of which is formed by ceramide.* It is the only sphingholipid without sugar.* The common sphinghomyelin deficiency is Neiman-Pick disease. The organelle which is involved is the lysosomes which allow accumulation of sphinghomyelin.* Signs & symptoms of Niemen pick's: Hepatosplenomegaly, decreased appetite, unsteady gait, ataxia, slurring of speech (due to accumulation of sphingholipids in neural tissue).", 'role': 'assistant'}]