This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Misc., Subject name: Pathology
[{'content': 'Bcl-2 is \nSelect and explain. \nA. Pro-apoptotic, B. Anti-apoptotic, C. Protein synthesis, D. Gene amplification', 'role': 'user'}, {'content': 'Answer: B \nExplanation: (B) Anti-apoptotic > The two main anti-apoptotic proteins are Bcl-2 and Bcl-x.> These anti-apoptotic proteins normally reside in mitochondrial membranes and the cytoplasm.> When cells are deprived of survival signals or subjected to stress, Bcl-2 and/or Bcl-x are lost from the mitochondrial membrane and are replaced by pro-apoptotic members of the family, such as Bak, Bax, and Bim. When Bcl-2/Bcl-x levels decrease, the permetability of the mitochondrial membrane increases, and several proteins that can activate the caspase cascade leak out.', 'role': 'assistant'}]