This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cardiovascular system, Subject name: Pharmacology
[{'content': 'The most significant adverse effect of ACE inhibition is \nSelect and explain. \nA. Hypotension, B. Hypeension, C. Hypocalcemia, D. Hypercalcemia', 'role': 'user'}, {'content': 'Answer: A \nExplanation: On initiation of therapy ACE inhibitors may cause significant hypotension -first dose phenomenon. Hence treatment should be staed with small doses and if patients are on diuretic it is temporarily stopped. Hyperkalemia is another side effect. Ref: KD tripathi 8th ed Page no 129', 'role': 'assistant'}]