This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Tumors, Subject name: Ophthalmology
[{'content': 'Second common malignancy in patients of retinoblastoma is? \nSelect and explain. \nA. Osteosarcoma, B. Ewing s sarcoma, C. Medulloblastoma, D. Osteoblastoma', 'role': 'user'}, {'content': "Answer: A \nExplanation: ANSWER: (A) OsteosarcomaREF: Khurana 4th ed p. 281Heritable germ line cases of retinoblastoma develop bilateral tumours and multifocal tumours, and carry a predisposition to develop trilateral tumours most notably pinealoblastomas and osteosarcomas.Retinoblastoma is most common primary intraocular malignanacy of childhood.It is characterized by Flexner winterstiener rosette , homer - wright rosetteLeucocoria or cat's reflex is most common manifestation.Strabismus is second most common manifestation.Predisposing gene is 13ql4", 'role': 'assistant'}]