This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Carbohydrates, Subject name: Biochemistry
[{'content': 'In the fed state, major fate of glucose-6-phosphate in tissues is: \nSelect and explain. \nA. Storage as fructose, B. Storage as glyceraldehyde-3-phosphate, C. Enters HMP shunt via ribulose-5-phosphate, D. Storage as glycogen', 'role': 'user'}, {'content': "Answer: D \nExplanation: Ans. D. Stored as Glycogen(Ref: Harper 31/e page 136,137)The uptake of glucose into the liver GLUT 2 is independent of insulin.In the well fed state, the concentration of glucose entering the liver increases, so does the rate of synthesis of glucose-6-phosphateThis is in excess of the liver's requirement for energy-yielding metabolism. So it is used mainly for synthesis of glycogen.In both liver and skeletal muscle, insulin acts to stimulate glycogen synthetase and inhibit glycogen phosphorylase.", 'role': 'assistant'}]