This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hemoglobinopathies: Sickle cell anemia, Subject name: Pathology
[{'content': 'Autosplenectomy is seen in: \nSelect and explain. \nA. Hereditary spherocytosis, B. Sickle cell disease, C. Thalassaemia, D. Autoimmune anemia', 'role': 'user'}, {'content': 'Answer: B \nExplanation: - In sickle cell anemia initially, congestive splenomegaly is seen. - Later, sickled RBC causes aerial occlusion - ischemic damage to spleen - resulting in Fibrosis of spleen / autosplenectomy.', 'role': 'assistant'}]