This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
[{'content': 'In glycolysis the first commited step is catalysed by: \nSelect and explain. \nA. 2,3 DPG, B. Glucokinase, C. Hexokinase, D. PFK', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Fructose 6 Phosphate is phosphorylated to Fructose\xa01, 6 Bisphosphate by Phosphofructokinase I (PFK-I)\nSecond irreversible step\nMajor regulatory step of Glycolysis\nCommitted step of GIycolysis because once Fructose\n1, 6 Bisphosphate is formed it should undergo glycolysis\nOtherwise called bottle neck of Glycolysis\n1 ATP is utilized.\n\nKey Concept:\n\nFirst Committed step is catalyzed by Phosphofructokinase\nThis is otherwise called the bottle neck of Glycolysis.', 'role': 'assistant'}]