This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Membranous Glomerulopathy and Membranoproliferative Glomerulopathy, Subject name: Pathology
[{'content': 'C-3 nephritic factor is associated with which of the following conditions? \nSelect and explain. \nA. MPGN Type 1, B. MPGN Type 2, C. Membranous nephropathy, D. Minimal change disease', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Dense-Deposit Disease (type II MPGN) Resulting in excessive activation of the alternative complement pathway. Normally, this C3 convease is labile, but more than 70% of patients with dense-deposit disease have a circulating autoantibody termed C3 nephritic factor (C3NeF) that binds the alternative pathway C3 convease and protects it from inactivation.', 'role': 'assistant'}]