This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of nucleic acids, Subject name: Biochemistry
[{'content': 'Orotic aciduria is due to deficiency of \nSelect and explain. \nA. Decarboxylase, B. Tyrosinase, C. Isomerase, D. Homogentisate oxidase', 'role': 'user'}, {'content': "Answer: A \nExplanation: Orotic aciduria an autosomal recessive disorder, can be caused by a deficiency in the enzyme UMPS, a bifunctional protein that includes the enzyme activities of orotate phosphoribosyltransferase and orotidine 5'-phosphate decarboxylase.", 'role': 'assistant'}]