This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Integrated QBank, Subject name: Unknown
[{'content': 'A 20-day old neonate presented with history of non-passage of meconium along with rectal prolapse, poor growth and delayed maturation. She has been hospitalized for the past 10 days due to respiratory tract infection. O/E Increased anteroposterior diameter of the chest Generalized hyperresonance Scattered coarse crackles Digital clubbing Protuberant abdomen Decreased muscle mass X ray abdomen was done. X ray abdomen was done. USG Abdomen ( Seen in antenatal records) All of the following drugs can be used in the treatment of the above-mentioned disease except: - Ivacaftor Dornase alpha Pulmozyme Mannitol \nSelect and explain. \nA. Only 1, B. 1 and 2, C. 2 and 3, D. All of the above', 'role': 'user'}, {'content': 'Answer: D \nExplanation: This is a case of cystic fibrosis in a neonate. Autosomal recessive Due to a homozygous defect of the CFTRgene located on chromosome 7q31.2 Most common defect being DF508 X-ray abdomen dilated air-filled small bowel loops and multiple air-fluid level on upright lateral view. Treatment: - Ivacaftor: most effective in those with G551D defect, only 2.3% patients Lumacaftor: designed for the common &paF508 mutation Lumacaftor and Ivacaftor: combination therapy: approved for &paF508 mutations Dornase alpha (Pulmozyme)- Cleaves extracellular DNA to reduce sputum viscosity. Mannitol- To improve mucous clearance in the lungs.', 'role': 'assistant'}]