This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Parasitology, Subject name: Microbiology
[{'content': 'Schistosomiasis is a disease characterized by granulomatous reactions to the ova or to products of the parasite at the place of oviposition. Clinical manifestations include which one of the following? \nSelect and explain. \nA. Bladder wall hyperplasia, B. Pulmonary embolism, C. Splenomegaly, D. Cardiac abnormalities', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Although the chronic stage of proliferation within tissues is distinctive in the different forms of schistosomiasis, a granulomatous reaction to the eggs and chemical products of the schistosome occurs in all forms of the disease. Schistosoma haematobium commonly involves the distal bowel and the bladder, as well as the prostate gland and seminal vesicles. Bladder calcification and cancer may ensue. S. mansoni affects the large bowel and the liver; presinusoidal portal hypertension, splenomegaly, and esophageal varices may be complications. Pulmonary hypertension, often fatal, may be seen with S. mansoni and S. japonicum disease. Eggs may be found in an unstained specimen of rectal mucosa or in stool. Urine microscopy and liver biopsy, when warranted, often prove positive. Schistosomiasis is best prevented by the elimination of the parasite in snails before human infection occurs.', 'role': 'assistant'}]