This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Fungal Drugs, Subject name: Pharmacology
[{'content': 'Fluconazole differs from ketoconazole in that: \nSelect and explain. \nA. It is not active by the oral route, B. It is a more potent inhibitor of drug metabolism, C. It is not effective in cryptococcal meningitis, D. It is unlikely to produce anti-androgenic side effects', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Fluconazole does not have anti-androgenic side effects. Ketoconazole is rarely used now a days because of several limitations like: Poor oral bioavailability Limited CNS penetration Powerful inhibition of microsomal enzymes Used in treatment of Cushing Syndrome Anti-androgenic adverse effects like gynaecomastia Fluconazole is preferred agent because it has: Very good oral absorption Maximum CNS penetration (therefore effective in cryptococcal meningitis). No inhibitory action on microsomal enzymes No anti-androgenic propey.', 'role': 'assistant'}]