This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autoimmune Diseases, Subject name: Pathology
[{'content': 'Least likely associated with SLE - \nSelect and explain. \nA. Anti ds DNA, B. Anti Sm, C. Anti topoisomerase, D. Anti histone', 'role': 'user'}, {'content': "Answer: C \nExplanation: Ans. is 'c' i.e., Anti topoisomerase Best screening test for SLE is demonstration of antinuclear antibodies :o Most sensitive test for SLE- Anti nuclear antibodies (ANA).o Most specific test for SLE- Anti ds DNA, Anti Sm.", 'role': 'assistant'}]