This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemical Mediators and Regulators of Inflammation, Subject name: Pathology
[{'content': 'Which cytokine activate macrophages - \nSelect and explain. \nA. IL-8, B. IFN-y, C. PAF, D. Leukotriene B4', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e., IFN-y Activated macrophageso Recent studies show that there are two types of activated macrophages : -1. Classically activated macrophages (M1)o These are activated by microbial products and cytokines like IFN-g.o These cells release lysosomal enzymes, NO, IL-1, and IL-12.o These cells are involved in microbicidal activities and pathogenic inflammation.2. Alternatively activated macrophages (M2).o These cells are activated by microbial products and cytokines like IL-4, IL-5.o These cells release IL-10, TGF-b.o These cells are involved in anti-inflamatory actions and wound repair.", 'role': 'assistant'}]