This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Fungal infections, Subject name: Dental
[{'content': 'Agents most effective and better tolerated in management of onychomycosis ? \nSelect and explain. \nA. Griseofulvin and caspofungin, B. Griseofulvin and ketoconazole, C. Itraconazole and terbinafine, D. Ciclopirox and griseofulvin', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Onychomycosis does not respond to topical therapy, although ciclopirox olamine (recent NEET) nail lacquer applied daily for a year is occasionally beneficial. The 3 anti-fungals being increasingly used for Rx of onychomycosis are: Drug for Rx onychomycosis Dose Terbinafine 250 mg/day for 6 and 12 wks in fingernail and toenail onychomycosis respectively. Itraconazole Pulse therapy: 200 mg twice daily for 1 wk/month for 2 and 3 consecutive months for finger and toenail onychomychosis respectively. Continuous regimen: 200 mg/day for 6 wks. Fluconazole 150 mg wkly for maximum period of 12 months', 'role': 'assistant'}]