This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunology Pa 3 (Graft, Autoimmunity, Immunodeficiency Disorders), Subject name: Microbiology
[{'content': 'Chediak higashi syndrome, defect is- \nSelect and explain. \nA. Fusion of lysosome, B. T-cells, C. B-cells, D. Complement', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Chediak higashi syndrome -Defective phagolysosomal fusion leading to decrease in melanocytes Severe Combined Immunodeficiency- Deficiency of Purine Nucleoside Phosphorylase Chronic Mucocutaneous Candidiasis- T cell disorder leading to recurrent candidiasis X linked Hyper IgM Syndrome- Deficiency of CD40 Ligand on activated T cell', 'role': 'assistant'}]