This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: recent papers  obst, Subject name: Gynaecology & Obstetrics
[{'content': 'Treatment of confirmed case of maternal toxoplasmosis with gestational age 16 weeks is by _________ \nSelect and explain. \nA. Spiramycin, B. Pyrimethamine-sulfonamide, C. Doxycycline, D. Cotrimoxazole', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Spiramycin is the treatement used in a confirmed case of maternal toxoplasmosis. Toxoplasmosis: Causative organism: Toxoplasma gondii Definitive host: Cat Perinatal problems: Primary infection in pregnancy causes fetal abnormalities due to transplacental transmission Earlier infection: Increased severity of infection (maximum in the first trimester). But, only 10% are infected in the first trimester. Risk of transmission increases with the period of gestation, but the risk of teratogenicity decreases. Severe disease: Tetrad of hydrocephalus or microcephaly, convulsions, chorioretinitis and cerebral calcification. Diagnosis: Acute infection: IgG and IgM antibodies or four fold increase in paired specimens 4 weeks apa. Management: Spiramycin Pyrimethamine: Sulfonamide (to be avoided inn first trimester)-when fetal infection is confirmed. Ref: Williams Obstetrics 25th edition Pgno: 1226', 'role': 'assistant'}]