This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Malaria Drugs, Subject name: Pharmacology
[{'content': 'What is DOC of Severe Complicated Falciparum Malaria is ? \nSelect and explain. \nA. Quinine, B. Aemether, C. Aesunate, D. Hydroxychloroquine', 'role': 'user'}, {'content': 'Answer: C \nExplanation: AEMESININS : Aemisinin and its three major semisynthetic derivatives in clinical use Dihydroaemisinin, Aemether and Aesunate are potent and Fast-acting Antimalarials. They are optimized for the treatment of Severe P. falciparum malaria and are also effective against the asexual erythrocytic stages of P.vivax. AESUNATE - All patients with Severe Falciparum Malaria should be treated with I/V or I/M Aesunate (atleast 24 hours). The semisynthetic aemisinins have been formulated for Oral (Dihydroaemisinin, Aesunate, and Aemether); Intramuscular (Aesunate and Aemether); Intravenous (Aesunate); and Rectal (Aesunate) routes. AEMETHER - is used only if Parenteral Aesunate is not available PROPEIES : Fastest acting Antimalarial drug Effective against MDR parasites Sho acting C/I in 1st Trimester', 'role': 'assistant'}]