This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'TGF-β is involved in all of the process of angiogenesis except: \nSelect and explain. \nA. Stimulates  fibroblast migration and proliferation, B. Formation of the vascular lumen, C. Increases the synthesis of collagen, D. Decreases the degradation of ECM', 'role': 'user'}, {'content': 'Answer: B \nExplanation: TGF-β\xa0stimulates fibroblast\xa0migration\xa0and proliferation, increases the synthesis of collagen and fibronectin, and decreases the degradation of ECM by inhibiting metalloproteinases. TGF-β is involved not only in scar formation after injury but also in the development of fibrosis in lung, liver, and kidneys that follows chronic inflammation.TGF-β also has anti-inflammatory effects that serve to limit and terminate inflammatory responses. It does this by inhibiting lymphocyte\xa0proliferation\xa0and\xa0the\xa0activity\xa0of other leukocytes.\nVEGFs,\xa0mainly\xa0VEGF-A, stimulates both migration and proliferation of endothelial cells, thus initiating the process of capillary sprouting\xa0in\xa0angiogenesis.\xa0It\xa0promotes\xa0vasodilation\xa0by stimulating the production of NO and contributes to the\xa0formation of the vascular lumen.\nRobin’s Textbook of pathology 10th ed Page 91', 'role': 'assistant'}]