This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Drugs & Other Biological Methods of Treatment, Subject name: Psychiatry
[{'content': 'Mode of action of Fluoxetine is - \nSelect and explain. \nA. GABA inhibition, B. Adrenergic neuron blocking agent, C. Inhibition axonal uptake of 5HT, D. Alpha adrenergic stimulation', 'role': 'user'}, {'content': "Answer: C \nExplanation: Ans. is 'c' Inhibit axonal uptake of 5HT Fluoxetine is a tricyclic antidepressant (like imipramine, Amitriptyline)While typically TCA inhibit uptake of both NA and 5HT by neurons.Fluoxetine is selective serotonin reuptake inhibitor (SSRI)Therefore it is devoid of following side effectsAnticholinergic *Sedation*Hypotension*Other SSRIsFluvoxamine*Paroxetine*Also remember mechanism of action of these atypical TCAsTianeptine - It increase rather than inhibit 5-HT uptake *Mianserin - does not inhibit either NA or 5-HT uptake, it blocks presynaptic alpha-2 receptors, increases release and turnover of NA in brain *", 'role': 'assistant'}]