This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': "Which of the following inflammatory mediator doesn't cause fever: \nSelect and explain. \nA. Nitric oxide, B. Prostaglandin, C. IL-1, D. TNF-alpha", 'role': 'user'}, {'content': 'Answer: A \nExplanation: Pyrogens A pyrogen is a substance that induces fever. These can be either internal (endogenous) or external (exogenous) to the body. The bacterial substance lipopolysaccharide (LPS), present in the cell wall of some bacteria, is an example of an exogenous pyrogen. Endogenous Pyrogens IL 1 TNF PGs Depyrogenation may be achieved through filtration, distillation, chromatography, or inactivation.', 'role': 'assistant'}]