This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Which of the following causes hemolytic anemia -a) Hereditary spherocytosisb) Infectionc)  Iron deficiencyd) Sickle cell anemiae) Copper deficiency \nSelect and explain. \nA. abd, B. bcd, C. abc, D. ab', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Hemolytic anemia may be of two types.\n\n\xa0Intracorpuuscular\n\nUnderlying cause of hemolysis is intrinsic to RBC, e.g.,\n\nDefect in membrane cytoskeleton →\xa0Hereditary spherocytosis\nDefect in red cell enzyme\xa0→\xa0G6PD deficiency.\nDisorder of hemoglobin synthesis\xa0\n\n\nDeficient globin synthesis →Thalassemia\nStructurally abnormal globin → Sickle cell anaemia.\n\t(hemoglobinopathies)\n\n\nMembrane defect\xa0→ Paroxysmal nocturnal hemoglobinuria\n\n\xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 \xa0 2. Extracorpuscular\nUnderlying cause of hemolysis is extrinsic, ie., not within RBC, e.g., : -\n\nImmunohemolytic anemia\nMicroangiopathic hemolytic anemia\xa0→ (i) TTP, \xa0(ii) HUS, \xa0(iii) DIC\nInfection\xa0→ Malaria\nMechanical trauma to RBC → rosthetic valve.\nHyperspienism', 'role': 'assistant'}]