This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': 'The diagnostic criteria as proposed by FLINTER for Alpo syndrome has all the features, EXCEPT: \nSelect and explain. \nA. Positive family history, B. Typical changes in renal biopsy specimen, C. High tone sensorineural deafness, D. Cardiovascular changes', 'role': 'user'}, {'content': 'Answer: D \nExplanation: Diagnostic criteria for classical X-linked Alpo syndrome. At least three of the following four criteria must be fulfilled for a diagnosis of Alpo syndrome to be made clinically: In a patient with microscopic hematuria A positive family history of hematuria with or without chronic renal failure. Typical ultrastructural GBM changes in a renal biopsy specimen. High-tone sensorineural deafness. Characteristic ophthalmological signs (lenticonus and/or macular flecks) Ref: Dan Med Bull 2009; 56:105-52', 'role': 'assistant'}]