This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Medical Illness Complicating Pregnancy, Subject name: Gynaecology & Obstetrics
[{'content': 'Which of the following perinatal infections has the highest risk of fetal infection in the first trimester \nSelect and explain. \nA. Hepatitis B virus, B. Syphillis, C. Toxoplasmosis, D. Rubella', 'role': 'user'}, {'content': 'Answer: D \nExplanation: RUBELLA Possibility of fetal infection is almost 90% when maternal transmission occurs during 1st trimester. its around 50% in the second trimester. Some of the possible effects are: Sensorineural Hearing loss, eye defects like cataracts and micro ophthalmia, Hea diseases like septal defects, Pulmonic stenosis, mental retardation. Also seen are Neonatal purpura, radiolucent bone disease & hepatospleenomegaly', 'role': 'assistant'}]