This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autonomic nervous system, Subject name: Pharmacology
[{'content': 'Which among the following is contraindicated in myasthenia patient? \nSelect and explain. \nA. Aminoglycosides, B. Sulphonamides, C. Penicillin, D. All', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ref:KD Tripathi pharmacology 7th edition (page.no: 745) All aminoglycosides reduce ACh release from the motor nerve endings. They interfere with the mobilization of centrally located synaptic vesicles to fuse with the terminal membrane (probably by antagonizing Ca2+) as well as decrease the sensitivity of the muscle endplates to ACh. Myasthenic weakness is accentuated Aminoglycosides. Neuromuscular blockers should be used cautiously in patients receiving aminoglycosides.', 'role': 'assistant'}]