This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hemoglobinopathies: Sickle cell anemia, Subject name: Pathology
[{'content': 'Which of the following statements is true of hereditary spherocytosis (HS)? \nSelect and explain. \nA. Pigment-type of gall stones are common, B. Diagnosis can be made in neonatal period easily by examination of a blood film, C. Intravascular hemolysis is a common feature, D. Autosomal recessive inheritance in majority of the cases', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Discussing the options about HS - a. TRUE D/t chronic hemolysis, pigmented stones are formed in gall bladder. b. FALSE In newborns, Spherocytosis & reticulocytosis are frequently minimal or absent c FALSE Hemolysis in hereditary spherocytosis is mainly extravascular d. FALSE 75% cases of HS have autosomal dominant inheritance Anisocytosis and several hyperchromic spherocytes are seen. Howell-Jolly bodies can be seen.', 'role': 'assistant'}]