This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
[{'content': 'Which of the following endocrine tumors is most commonly seen in MEN I? \nSelect and explain. \nA. Insulinoma, B. Gastrinoma, C. Glucagonoma, D. Somatostatinoma', 'role': 'user'}, {'content': 'Answer: B \nExplanation: "Most common neuroendocrine tumour associated with MEN I is Gastrinoma."\n\nMEN -1 is also called werner syndrome.\nIt is characterized by abnormalities involving the\n\n- Parathyroid\n- Pancreas\n- And Pituitary gland thus the mnemonic device the "3 Ps".\nParathyroid\n\nPrimary hyperparathyroidism is the most common manifestation of MEN I (80% to 90%) of patients.\nIt is the initial manifestation of the disorder in most patients appearing in almost all patients by the age of 40 to 50.\nParathyroid abnormality includes both adenoma and hyperplasia.\nHypercalcemia occurs due to hyperparathyroidism.\n\n\nPancreas \n\nPancreatic islet cell tumours are the 2nd most common abnormalities in MEN I syndrome.\nGastrinoma is the most common enteropancreatic tumour observed in MEN I.\nInsulinoma are second most common enteropancreation tumour in MEN I.\n\nPituitary\n\nMost frequent anterior pituitary tumour encountered in MEN I is prolactinoma.\n\nAlso remember these important facts about MEN I syndrome -\n\nMEN I syndrome is caused by germ line mutations in MEN I gene at 11q13.\nMEN I is a classic tumour suppressor gene.\nThe dominant clinical manifestations of MENI are due to peptide hormones overproduction such as Zollinger Ellison syndrome due to gastrinoma and recurrent hypoglycemia. Hypercalcemia can result due to hyperparathyroidism.', 'role': 'assistant'}]