This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Sedative-Hypnotics and Parkinsonism, Subject name: Pharmacology
[{'content': "Levodopa is contraindicated in:- \nSelect and explain. \nA. Alzheimer's disease, B. Multiple sclerosis, C. Glaucoma, D. Parkinsonism", 'role': 'user'}, {'content': "Answer: C \nExplanation: Levo-dopa may cause mydriasis, so it is contraindicated in angle closure glaucoma. Vitamin complexes containing pyridoxine decrease the effectiveness of levo-dopa (pyridoxine is a cofactor of dopa decarboxylase and increases the formation of dopamine in the periphery. This results in decrease in l-dopa's central penetration). Abrupt withdrawal of levodopa may precipitate neuroleptic malignant syndrome. Levo-dopa should be given carefully in patients with active peptic ulcer (increased risk of bleeding) and malignant melanoma (levo-dopa is a precursor of melanin).", 'role': 'assistant'}]