This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunology, Subject name: Microbiology
[{'content': 'Which of the following antigen is found within the nuclei of infected hepatocytes and NOT usually in the peripheral circulation in Hepatitis B infection? \nSelect and explain. \nA. HBeAg, B. HBcAg, C. Anti-HBc, D. HBsAg', 'role': 'user'}, {'content': "Answer: B \nExplanation: HBcAg is assembled as the nucleocapsid core paicles. It is not secreted and does not circulate in blood, but can be demonstrated in hepatocytes by immunofluorescence. - HBcAg is not demonstrable in circulation because it is enclosed within the HBsAg coat. But its antibody anti-HBc appears in serum a week or two after the appearance of HBsAg. Reference : Anathanarayan & paniker's 9th edition, pg no: 544,546 <\\p>", 'role': 'assistant'}]