This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Respiratory chain, Subject name: Biochemistry
[{'content': 'Dinitrophenol causes \nSelect and explain. \nA. Inhibition of ATP synthase, B. Inhibition of electron transpo, C. Uncoupling of oxidation and phosphorylation, D. Accumulation of ATP', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Mechanism of Action of DNP as uncoupler Dinitrophenol (DNP) a potent uncoupler is ampipathic and increase the permeability of the lipoid inner mitochondrial membrane to protons (H+), thus reducing the electrochemical potential and sho-circuiting the ATP synthase. In this way, oxidation can proceed without phosphorylation. Note: DNP was used for weight loss. But it was discontinued due to hypehermia and other side effects.Ref: MN Chatterjea Textbook of Medical Biochemistry, 8th edition, page no: 146', 'role': 'assistant'}]