This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Basic Concepts and Vascular changes of Acute Inflammation, Subject name: Pathology
[{'content': 'Fifth clinical sign i.e., loss of function (functio laesa) was added by: \nSelect and explain. \nA. Rudolf Virchow, B. Elie Metchinkoff, C. Louis Pasteur, D. George Bernard', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Acute inflammation Four cardinal signs of inflammation was given by Celsus. Rubor (redness) Tumor (swelling) Calor (heat) Dolor (pain). These signs are hallmarks of acute inflammation. A fifth clinical sign, loss of function (functio laesa), was added by Rudolf Virchow in the 19th century. Metchinkoff described process of phagocytosis.', 'role': 'assistant'}]