This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': 'Hereditory spherocytosis is due to deficiency of \nSelect and explain. \nA. Ankyrin, B. Actin, C. Selectin, D. Integrin', 'role': 'user'}, {'content': 'Answer: A \nExplanation: HS is caused by diverse mutations that lead to an insufficiency of membrane skeletal components.\nThe pathogenic mutations most commonly affects ankyrin, band 3, spectrin, or band 4.2.', 'role': 'assistant'}]