This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
[{'content': "TRUE about Heparin Indiced Thrombocytopenia (HIT) syndrome are all, EXCEPT: \nSelect and explain. \nA. LMWH shouldn't be used for treatment, B. It causes both aerial and venous thrombosis, C. More common with fractionated heparin, D. Occurs commonly in about a week of heparin therapy", 'role': 'user'}, {'content': 'Answer: C \nExplanation: Frequency of HIT after exposure to unfractionated heparin (UFH) is 1% to 5%, whereas the frequency of HIT associated with the used of low-molecular-weight heparin (LMWH) is only 1%. HIT occur due to the formation of antibodies against the complex of heparin bonded to platelet factor 4. Most patients develop HIT after exposure to heparin for 4 days but may occur suddenly in patients with recent exposure (< 100 days). It is paradoxically associated with increased risk of aerial and venous thrombosis. The 4 "T"s have been recommended to be used in a diagnostic algorithm for HIT: thrombocytopenia, timing of platelet count drop, thrombosis and other sequel such as localized skin reactions, and other cause of thrombocytopenia not evident.', 'role': 'assistant'}]