This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemical Mediators and Regulators of Inflammation, Subject name: Pathology
[{'content': 'Chemotaxis is mediated by? \nSelect and explain. \nA. C5a, B. IL-2, C. IFN-g, D. IL-5', 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., C5a o C5a is the most powerful chemo-attractant (chemokine).Chemotaxiso Chemotaxis is unidirectional locomotion of leukocytes towards the site of injury, oriented along a chemical gradient. This chemical gradient is created by substances called chemoattractants (chemotactic agents), which may be exogenous (bacterial products) or endogenous (C5a, LTB-4, IL-1, TNF, IL-8).", 'role': 'assistant'}]