This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.N.S, Subject name: Medicine
[{'content': "Elongated filaments in Pick's disease consist of \nSelect and explain. \nA. Hyperphosphorylated tau, B. Ubiquitin, C. Alpha-synuclein, D. Beta-synuclein", 'role': 'user'}, {'content': "Answer: A \nExplanation: Harrison's principles of internal medicine 17th edition. *In Pick's disease dementia is frontotemporal dementia *Molecular basis - tau *Causal genes and chromosome - tau exon and intron mutation(17) *Susceptibility - H1 tau haplophytes * Pathology - tau inclusions,pick bodies,neurofibrillary tangles", 'role': 'assistant'}]