This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Neoplasia, Subject name: Pathology
[{'content': 'Guardian of the genes is? \nSelect and explain. \nA. Rb, B. p53, C. p16, D. p73', 'role': 'user'}, {'content': "Answer: B \nExplanation: Ans. is 'b' i.e., p53 * p53 is a tumor suppressor gene. p53 gene is located on chromosome 17. p53 acts as molecular policeman that prevents the propagation of genetically damage cell.* p-53 is the most common target for genetic alteration in human tumors; A little over 50% of human tumors contain mutation in this gene.(Note - Amongst oncogene RAS is involved most commonly)* The major functional activities of the p53 protein are cell cycle arrest and initiation of apoptosis in response to DNA damage.", 'role': 'assistant'}]