This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
[{'content': 'L–asparaginase is particularly used in which type of leukemia – \nSelect and explain. \nA. AML, B. CML, C. ALL, D. CLL', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Treatment of ALL \n\nTreatment of ALL is divided into 4 stages.\n\n\nInduction (to attain remission)\nCNS therapy (to prevent CNS spread)\nIntensification (Consolidation)\nMaintenance (Continuation) therapy\n\n\n\nThe total duration oLtreatment ranges between 2 and 21/2 years.\n\n1. Induction of remission\n\nInduction therapy is used to attain remission, i.e., to eradicate the leukemic cells from bone marrow.\nDrugs used are Vincristine, Prednisolone, L Asparginase, Anthracycline\nDuration of therapy is 4-6 weeks.\n\n2. CNS therapy\n\nMost children with leukemia have subclinical CNS involvement at the time of diagnosis.\nMoreover, CNS acts as a sanctuary site where leukemic cells are protected from systemic chemotherapy because of blood brain barrier.\nSo, treatment to keep leukemia cells from spreading to the CNS is often started with induction.\nTreatment include → Intrathecal methotrexate plus cranial radiation.\n\n3. Intensification\n\nIf the patient goes into remission, the next step is to intensify the therapy for a short period.\nDrugs used are → Methotrexate, L - Asparginase, Epipodophyllotoxin, Cyclophosphamide, Cytarabine\n\n4. Maintenance therapy\n\nAfter consolidation, the patient is generally put on a maintenance therapy to maintained the remission state and prevent relapse.\nDrugs used are → 6-mercaptopurine, Methotrexate, Prednisolone, Vincristine\nDuration of maintenance therapy is 2-2.5 years.', 'role': 'assistant'}]