This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Pharmacology
[{'content': 'Patient with head injuries with rapidly increasing intracranial tension without hematoma, the drug of choice for initial management would be: \nSelect and explain. \nA. Furosemide, B. Steroids, C. 20% Mannitol, D. Glycine', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Mannitol is an osmotic diuretic. It is used for Increased intracranial or intraocular tension (acute congestive glaucoma, head injury, stroke, etc.): by osmotic action, it encourages the movement of water from brain parenchyma, CSF and aqueous humor; The dose is 1-1.5 g/kg is infused over 1 hour as 20% solution to transiently raise plasma osmolarity. It is also used before and after ocular /brain surgery to prevent the acute rise in intraocular/intracranial pressure. osmotic diuretics are excreted unchanged in the urine ( Essentials of Medical Pharmacology, K.D Tripathi,6th edition, page 572 ) eding', 'role': 'assistant'}]