This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
[{'content': "Mutation in COL4A5 chain the diagnosis ? \nSelect and explain. \nA. Alpo's syndrome, B. Good pasture's syndrome, C. Hereditary Non-polyposis colon cancer, D. Keroderma pigmentosum", 'role': 'user'}, {'content': "Answer: A \nExplanation: Ans. is 'a' i.e., Alpo's syndromeo Manifestations of Alpo's syndrome are due to abnormal a3 (COL4A3), a4 (COL4A4), or a5 (COL4A5). o This is due to mutations of :i) COL4A5 in classic X-linked formii) COL4A.3 or COL4A4 in autosomal forms.", 'role': 'assistant'}]