This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunology, Subject name: Microbiology
[{'content': 'The most impoant cells in type I hypersensitivity - \nSelect and explain. \nA. Macrophages, B. Mast cells, C. Neutrophils, D. Lymphocytes', 'role': 'user'}, {'content': "Answer: B \nExplanation: Type I hypersensitivity reaction is IgE dependent. Cytotoxic IgE antibodies are fixed on the surface of tissue cells ( mast cells and basophils) in sensitized individuals. The antigen combines with the cell fixed antibody, leading to release of a phpharmacologicallyctive substance that produces the clinical reaction . Reference : Anathanarayan & paniker's 9th edition, pg: 162 <\\p>", 'role': 'assistant'}]