This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Breast, Subject name: Surgery
[{'content': 'In cases of Cancer breast with Her-2 neu amplification when will you do FISH? \nSelect and explain. \nA. HER 2 neu 1 +, B. HER 2 neu 2+, C. Irrespective of Her 2 neu, D. HER 2 neu 3+', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Ans. (b) HER 2 neu 2+(Ref NCCN Guidelines for Cancer breast)* HER 2 Status of the cancer breast is routinely done by IHC study with values from "0 to + l, +2 and +3.* Recently FISH (Fluorescence Insitu Hybridization) is used to detect HER 2 amplification and advised for IHC HER 2 positive cases of values +2 onwards.* 20% incidence is detected and treated by Trastuzumab (HER 2 receptor inhibitor)', 'role': 'assistant'}]