This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Valvular hea diseases, Subject name: Medicine
[{'content': 'What is the impact on fetus in case of use of Indomethacin in utero in third trimester? \nSelect and explain. \nA. Patent ductus aeriosus, B. Early closure of ductus aeriosus, C. Ventricular septal defect, D. Atrial septal defect', 'role': 'user'}, {'content': 'Answer: B \nExplanation: Prostaglandins helps to keep ductus aeriosus open. Indomethacin inhibits prostaglandins levels | So, closure of ductus aeriosus | DOC for PDA', 'role': 'assistant'}]