This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology and breast, Subject name: Surgery
[{'content': 'BRCA 1positive woman hav ..........% increased risk of breast carcinoma \nSelect and explain. \nA. 10, B. 20, C. 40, D. 60', 'role': 'user'}, {'content': 'Answer: C \nExplanation: Mutation of tumour suppressor genes BRCA1/BRCA2 is thought to be involved with high-risk of breast carcinoma. BRCA1 mutation is having more risk (35-45%) than BRCA2 mutation It is located in long arm of chromosome 17, whereas BRCA2 is located in long arm of chromosome 13. BRCA1 more commonly shows ER negative status, high grade, aneuploid with raised S fraction than BRCA2 which shows ER positive status. BRCA1 is associated with increased risk in males. Lifelong risk of breast cancer in BRCA1 and BRCA2 mutations is 50-70%. Both are associated with high-risk for ovarian cancer. Ref; (page no;530 ) 5th edition of SRB&;S manual of Surgery', 'role': 'assistant'}]