This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolic Disorders of Bone, Subject name: Orthopaedics
[{'content': "Which is the drug of choice in Paget's disease? \nSelect and explain. \nA. Alendronate, B. Steroids, C. Allopurinol, D. Calcitonin", 'role': 'user'}, {'content': "Answer: A \nExplanation: Treatment of Paget's disease Mithramycin (Plicamycin), an anti-neoplastic agent (toxic to osteoclast) was the first drug used for paget's disease. DOC is Bisphosphonates - Etidronate was used first, Alendronate , Risedronate is preferred now. Calcitonin is used for acute relief of pain(temporary effect).", 'role': 'assistant'}]