This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Blood, Subject name: Pathology
[{'content': 'Which is not transmitted familial: \nSelect and explain. \nA. Factor V Leiden mutation, B. Thalassemia, C. Hemophilia, D. Sickle cell anemia', 'role': 'user'}, {'content': 'Answer: A \nExplanation: Ans. a. Factor V Leiden mutationAutosomal recessive diseases*. Often due to defects in structural genes.*. Many generations, both males and females are affected.Sickle cell anemia, ThalassemiasX-linked recessive disorders*. Sons of heterozygous mothers have a 50% chance of being affected.*. No male-to-male transmission.*. Skips generations.Hemophilia', 'role': 'assistant'}]